Qianjin Wang, Honghong Ren, Chunwang Li, Zongchang Li, Jinguang Li, Hong Li, Lulin Dai, Min Dong, Jun Zhou, Jingqi He, Joseph O'Neill, Yanhui Liao, Ying He, Tieqiao Liu, Xiaogang Chen, Jinsong Tang
Studies of schizophrenia (SCZ) have associated auditory verbal hallucinations (AVH) with structural and functional abnormalities in frontal cortex, especially medial prefrontal cortex (mPFC). Although abnormal prefrontal network connectivity associated with language production has been studied extensively, the relationship between mPFC dysfunction (highly relevant to the pathophysiology of SCZ) and AVH has been rarely investigated. In this study, proton magnetic resonance spectroscopy was used to measure metabolite levels in the mPFC in 61 SCZ patients with persistent AVH (pAVH), 53 SCZ patients without AVH (non-AVH), and 59 healthy controls (HC)...
March 23, 2022: Translational Psychiatry