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https://www.readbyqxmd.com/read/28631188/role-of-clu-picalm-and-tnk1-genotypes-in-aging-with-and-without-alzheimer-s-disease
#1
Davide Seripa, Francesco Panza, Giulia Paroni, Grazia D'Onofrio, Paola Bisceglia, Carolina Gravina, Maria Urbano, Madia Lozupone, Vincenzo Solfrizzi, Alessandra Bizzarro, Virginia Boccardi, Chiara Piccininni, Antonio Daniele, Giancarlo Logroscino, Patrizia Mecocci, Carlo Masullo, Antonio Greco
Healthy and impaired cognitive aging may be associated to different prevalences of single-nucleotide polymorphisms (SNPs). In a multicenter case-control association study, we studied the SNPs rs11136000 (clusterin, CLU), rs541458 (phosphatidylinositol binding clatrin assembly protein, PICALM), and rs1554948 (transcription factor A, and tyrosine kinase, non-receptor, 1, TNK1) according to the three age groups 50-65 years (group 1), 66-80 years (group 2), and 80+ years (group 3) in 569 older subjects without cognitive impairment (NoCI) and 520 Alzheimer's disease (AD) patients...
June 19, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28621003/effect-of-periodontal-therapy-with-systemic-antimicrobials-on-parameters-of-metabolic-syndrome
#2
Sergio Bizzarro, Ubele van der Velden, Wijnand J Teeuw, Victor E A Gerdes, Bruno G Loos
AIM: To investigate the effect of basic periodontal therapy (BPT) with antimicrobials (AM) on the parameters of metabolic syndrome (MetS) (waist circumference, systolic/diastolic blood pressure [BP], HDL-cholesterol, triglycerides, glucose). METHODS: 110 periodontitis patients without known comorbidities and unaware of possible MetS, were randomly assigned to BPT (n=56) or BPT+AM (n=54) and followed for 12 months post-therapy. Number of patients with undiagnosed MetS, was also determined...
June 16, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28562267/an-initiative-to-improve-the-quality-of-care-of-infants-with-neonatal-abstinence-syndrome
#3
Matthew R Grossman, Adam K Berkwitt, Rachel R Osborn, Yaqing Xu, Denise A Esserman, Eugene D Shapiro, Matthew J Bizzarro
BACKGROUND AND OBJECTIVES: The incidence of neonatal abstinence syndrome (NAS), a constellation of neurologic, gastrointestinal, and musculoskeletal disturbances associated with opioid withdrawal, has increased dramatically and is associated with long hospital stays. At our institution, the average length of stay (ALOS) for infants exposed to methadone in utero was 22.4 days before the start of our project. We aimed to reduce ALOS for infants with NAS by 50%. METHODS: In 2010, a multidisciplinary team began several plan-do-study-act cycles at Yale New Haven Children's Hospital...
May 18, 2017: Pediatrics
https://www.readbyqxmd.com/read/28411947/central-line-associated-bloodstream-infections-in-the-nicu-successes-and-controversies-in-the-quest-for-zero
#4
Renée E Mobley, Matthew J Bizzarro
Central line-associated bloodstream infections (CLABSI) are among the most common healthcare-acquired infections in the neonatal intensive care unit (NICU) population and are associated with an increased risk of morbidity and mortality, as well as increased healthcare costs, and duration of hospitalization. Over the past decade, numerous local, statewide, and national quality improvement initiatives have resulted in a significant reduction in CLABSI rates. The majority of successful initiatives have utilized similar strategies to implement and sustain their efforts, including education of NICU staff in the principles of quality improvement, creation and implementation of central line insertion and maintenance bundles and methods for assessing compliance, formation of dedicated central line insertion and maintenance teams, and utilization of reliable and effective methods for collecting, analyzing, and displaying data...
April 2017: Seminars in Perinatology
https://www.readbyqxmd.com/read/28371800/three-dimensional-evaluation-of-the-maxillary-arch-and-palate-in-unilateral-cleft-lip-and-palate-subjects-using-digital-dental-casts
#5
Chiara Generali, Jasmina Primozic, Stephen Richmond, Maria Bizzarro, Carlos Flores-Mir, Maja Ovsenik, Letizia Perillo
Objectives: To assess arch width, palatal surface area, and volume in surgically treated unilateral cleft lip and palate (UCLP) in mixed dentition children in comparison with non-cleft lip and palate (NCLP) children using a 3D laser scanning. Materials and Methods: 38 subjects (Caucasian origin), 5.63-11.9 years of age (mean, 9.33 ± 1.67 years), were included. 19 in each group (UCLP and NCLP). Digital dental casts were obtained using a 3 Shape R700 laser scanner...
March 25, 2017: European Journal of Orthodontics
https://www.readbyqxmd.com/read/28206997/pulmonary-hypertension-in-preterm-infants-results-of-a-prospective-screening-program
#6
C G Weismann, J D Asnes, A Bazzy-Asaad, C Tolomeo, R A Ehrenkranz, M J Bizzarro
OBJECTIVE: Determine prevalence and associations with pulmonary hypertension (PH) in preterm infants. STUDY DESIGN: Prospective institutional echocardiographic PH screening at 36 to 38 weeks' corrected gestational age (GA) for infants born <32 weeks' GA who had bronchopulmonary dysplasia (BPD; group BPD), and infants without BPD who had a birth weight (BW) <750 g, or clinical suspicion for PH (group NoBPD). RESULTS: Two hundred and four infants were screened (GA 25...
February 16, 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/28190975/reduced-platelet-hyper-reactivity-and-platelet-leukocyte-aggregation-after-periodontal-therapy
#7
Efthymios Arvanitidis, Sergio Bizzarro, Elena Alvarez Rodriguez, Bruno G Loos, Elena A Nicu
BACKGROUND: Platelets from untreated periodontitis patients are hyper-reactive and form more platelet-leukocyte complexes compared to cells from individuals without periodontitis. It is not known whether the improvement of the periodontal condition achievable by therapy has beneficial effects on the platelet function. We aimed to assess the effects of periodontal therapy on platelet reactivity. METHODS: Patients with periodontitis (n = 25) but unaffected by any other medical condition or medication were included and donated blood before and after periodontal therapy...
2017: Thrombosis Journal
https://www.readbyqxmd.com/read/28139937/risk-factors-for-tracheostomy-requirement-in-extremely-low-birth-weight-infants
#8
Orly L Levit, Veronika Shabanova, Alia Bazzy-Asaad, Matthew J Bizzarro, Vineet Bhandari
AIM: To identify variables that affect the risk of tracheostomy in a population of extremely low birth weight (ELBW) infants. METHODS: A retrospective matched case-control study was conducted. ELBW infants with a tracheostomy were compared with controls without tracheostomy. Data collection included demographics, detailed information about each intubation and extubation attempt, the use of steroids and the presence of comorbidities. Statistical analyses include conditional logistic regression and Poisson regression for clustered observations...
February 21, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28099523/the-role-of-liquid-based-cytology-and-ancillary-techniques-in-the-peritoneal-washing-analysis-our-institutional-experience
#9
Esther Rossi, Tommaso Bizzarro, Maurizio Martini, Adhemar Longatto-Filho, Fernando Schmitt, Anna Fagotti, Giovanni Scambia, Gian Franco Zannoni
BACKGROUND: The cytological analysis of peritoneal effusions serves as a diagnostic and prognostic aid for either primary or metastatic diseases. Among the different cytological preparations, liquid based cytology (LBC) represents a feasible and reliable method ensuring also the application of ancillary techniques (i.e immunocytochemistry-ICC and molecular testing). METHODS: We recorded 10348 LBC peritoneal effusions between January 2000 and December 2014. They were classified as non-diagnostic (ND), negative for malignancy-NM, atypical-suspicious for malignancy-SM and positive for malignancy-PM...
2017: PloS One
https://www.readbyqxmd.com/read/28041971/clinicopathological-analysis-of-mixed-endometrial-carcinomas-clinical-relevance-of-different-neoplastic-components
#10
COMPARATIVE STUDY
Esther Diana Rossi, Tommaso Bizzarro, Giorgia Monterossi, Frediano Inzani, Francesco Fanfani, Giovanni Scambia, Gian Franco Zannoni
Mixed endometrial carcinomas (MECs) refer to tumors characterized by 2 or more distinct histotypes mostly that comprised endometrioid (EC) and serous/clear cell carcinomas (SC/CC). The specific quantification of these distinct components represents a challenging and critical point for both prognosis and management. Herein, we analyze a large series of MEC and compare them with EC and SC/CC. We evaluated a series of 69 MECs between January 2002 and December 2015. We compared the MEC series with 186 ECs (including 117 endometrioid G3), 31 SCs, and 38 CCs...
April 2017: Human Pathology
https://www.readbyqxmd.com/read/28001329/fna-biopsy-of-secondary-nonlymphomatous-malignancies-in-salivary-glands-a-multi-institutional-study-of-184-cases
#11
He Wang, Raza S Hoda, William Faquin, Esther Diana Rossi, Nihar Hotchandani, Tianlin Sun, Marc Pusztaszeri, Tommaso Bizzarro, Massimo Bongiovanni, Viren Patel, Nirag Jhala, Guido Fadda, Yun Gong
BACKGROUND: Secondary malignancies of salivary glands (SMSGs) are among the most common malignant neoplasms to involve the salivary glands. Fine-needle aspiration biopsy (FNAB) of SMSG can present diagnostic challenges. The current report presents the largest such FNAB series to date. METHODS: A search of the pathology database from 6 academic institutions identified 184 FNAB cases of nonlymphomatous SMSG. RESULTS: Of the 184 cases, 171 were of the parotid glands, and 13 were of the submandibular glands; 130 patients were men, and 54 were women, and the mean patient age at diagnosis was 68 years...
February 2017: Cancer
https://www.readbyqxmd.com/read/27966635/boosting-adaptive-immunity-a-new-role-for-pafr-antagonists
#12
Marianna M Koga, Bruna Bizzarro, Anderson Sá-Nunes, Francisco J Rios, Sonia Jancar
We have previously shown that the Platelet-Activating Factor Receptor (PAFR) engagement in murine macrophages and dendritic cells (DCs) promotes a tolerogenic phenotype reversed by PAFR-antagonists treatment in vitro. Here, we investigated whether a PAFR antagonist would modulate the immune response in vivo. Mice were subcutaneously injected with OVA or OVA with PAFR-antagonist WEB2170 on days 0 and 7. On day 14, OVA-specific IgG2a and IgG1 were measured in the serum. The presence of WEB2170 during immunization significantly increased IgG2a without affecting IgG1 levels...
December 14, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27941541/cytopathology-of-follicular-cell-nodules
#13
REVIEW
Esther D Rossi, Tommaso Bizzarro, Maurizio Martini, Luigi M Larocca, Fernando Schmitt, Philippe Vielh
The detection of thyroid nodules, consisting of different diseases, represents a common finding in population. Their evaluation and diagnosis are mostly achieved with fine-needle aspiration cytology (FNAC). Even though the majority of thyroid nodules are correctly diagnosed, a total of 25% to 30% of them are classified "indeterminate" comprising lesions with varying risk of malignancy and different types of management. Although the number of thyroid FNACs, including small lesions, is increasing due to the reliance upon sonographic and cytologic interpretations, there are issues concerning cytomorphologic interpretation and interobserver reproducibility...
January 2017: Advances in Anatomic Pathology
https://www.readbyqxmd.com/read/27850544/906-determination-of-indication-based-extended-interval-gentamicin-dosing-regimens-for-neonates
#14
Michelle Rychalsky, Meghan Rowcliffe, Jessica Vital-Carona, Laura Broome, Sarah Kelly, Matthew Bizzarro
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27834582/hypoxia-regulates-anxa1-expression-to-support-prostate-cancer-cell-invasion-and-aggressiveness
#15
Valentina Bizzarro, Raffaella Belvedere, Vincenzo Migliaro, Elena Romano, Luca Parente, Antonello Petrella
Annexin A1 (ANXA1) is a Ca(2+)-binding protein overexpressed in the invasive stages of prostate cancer (PCa) development; however, its role in this tumor metastatization is largely unknown. Moreover, hypoxic conditions in solid tumors have been related to poor prognosis in PCa patients. We have previously demonstrated that ANXA1 is implicated in the acquisition of chemo-resistant features in DU145 PCa cells conferring them a mesenchymal/metastatic phenotype. In this study, we have investigated the mechanisms by which ANXA1 regulates metastatic behavior in LNCaP, DU145 and PC3 cells exposed to hypoxia...
May 4, 2017: Cell Adhesion & Migration
https://www.readbyqxmd.com/read/27738305/somatic-mutations-in-solid-tumors-a-spectrum-at-the-service-of-diagnostic-armamentarium-or-an%C3%A2-indecipherable-puzzle-the-morphological-eyes-looking-for-braf-and-somatic-molecular-detections-on-cyto-histological-samples
#16
REVIEW
Esther Diana Rossi, Maurizio Martini, Tommaso Bizzarro, Fernando Schmitt, Adhemar Longatto-Filho, Luigi Maria Larocca
This review article deals with the analysis and the detection of the morphological features associated with somatic mutations, mostly BRAFV600E mutation, on both cytological and histological samples of carcinomas. Few authors demonstrated that some architectural and specific cellular findings (i.e. polygonal eosinophilic cells defined as "plump cells" and sickle-shaped nuclei) are able to predict BRAF V600E mutation in both cytological and histological samples of papillary thyroid carcinoma (PTC) as well as in other carcinomas...
January 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/27717284/young-investigator-challenge-the-morphologic-analysis-of-noninvasive-follicular-thyroid-neoplasm-with-papillary-like-nuclear-features-on-liquid-based-cytology-some-insights-into-their-identification
#17
Tommaso Bizzarro, Maurizio Martini, Sara Capodimonti, Patrizia Straccia, Celestino Pio Lombardi, Alfredo Pontecorvi, Luigi Maria Larocca, Esther Diana Rossi
BACKGROUND: Noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) represents a challenge for the diagnosis and management of thyroid carcinoma. Some authors have proposed histological criteria that are able to distinguish NIFTPs from invasive follicular variant of papillary thyroid carcinoma (I-FVPTC). Hence, NIFTPs may have repercussions in the diagnostic categories on fine-needle aspiration. In the current study, the authors evaluated the criteria for NIFTPs on liquid-based cytology samples...
October 2016: Cancer
https://www.readbyqxmd.com/read/27634418/patient-with-rapidly-evolving-neurological-disease-with-neuropathological-lesions-of-creutzfeldt-jakob-disease-lewy-body-dementia-chronic-subcortical-vascular-encephalopathy-and-meningothelial-meningioma
#18
Maria Gabriella Vita, Dorina Tiple, Alessandra Bizzarro, Anna Ladogana, Elisa Colaizzo, Sabina Capellari, Marcello Rossi, Piero Parchi, Carlo Masullo, Maurizio Pocchiari
We report a case of rapidly evolving neurological disease in a patient with neuropathological lesions of Creutzfeldt-Jakob disease (CJD), Lewy body dementia (LBD), chronic subcortical vascular encephalopathy and meningothelial meningioma. The coexistence of severe multiple pathologies in a single patient strengthens the need to perform accurate clinical differential diagnoses in rapidly progressive dementias.
April 2017: Neuropathology: Official Journal of the Japanese Society of Neuropathology
https://www.readbyqxmd.com/read/27627668/what-s-growing-on-general-practitioner-s-stethoscope
#19
A Carducci, M Cargnelutti, F Tassinari, A Bizzarro, G Cordio, S Carletti, L Maccarini, G Pelissero
BACKGROUND: Non-critical medical devices, as stethoscopes, have long been considered as vectors in microorganisms' transmission. Cleaning standards for non-critical medical equipment are often unclear. This study was designed to assess the attitude of General Practitioners (GPs) towards cleaning their stethoscope and the degree of microbiological contamination of doctor's instrument in outpatient setting. STUDY DESIGN: Observational, crossover study. METHODS: A structured questionnaire was administered to GPs to test their knowledge about medical instrument's cleanliness recommendations and the surface of the diaphragm of their stethoscopes was analyzed for bacteriological isolates using mass spectrometry technique...
September 2016: Annali di Igiene: Medicina Preventiva e di Comunità
https://www.readbyqxmd.com/read/27563152/magnesium-and-54-cr-isotope-compositions-of-carbonaceous-chondrite-chondrules-insights-into-early-disk-processes
#20
Mia B Olsen, Daniel Wielandt, Martin Schiller, Elishevah M M E Van Kooten, Martin Bizzarro
We report on the petrology, magnesium isotopes and mass-independent (54)Cr/(52)Cr compositions (μ(54)Cr) of 42 chondrules from CV (Vigarano and NWA 3118) and CR (NWA 6043, NWA 801 and LAP 02342) chondrites. All sampled chondrules are classified as type IA or type IAB, have low (27)Al/(24)Mg ratios (0.04-0.27) and display little or no evidence for secondary alteration processes. The CV and CR chondrules show variable (25)Mg/(24)Mg and (26)Mg/(24)Mg values corresponding to a range of mass-dependent fractionation of ~500 ppm (parts per million) per atomic mass unit...
October 15, 2016: Geochimica et Cosmochimica Acta
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