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https://www.readbyqxmd.com/read/28206997/pulmonary-hypertension-in-preterm-infants-results-of-a-prospective-screening-program
#1
C G Weismann, J D Asnes, A Bazzy-Asaad, C Tolomeo, R A Ehrenkranz, M J Bizzarro
OBJECTIVE: Determine prevalence and associations with pulmonary hypertension (PH) in preterm infants. STUDY DESIGN: Prospective institutional echocardiographic PH screening at 36 to 38 weeks' corrected gestational age (GA) for infants born <32 weeks' GA who had bronchopulmonary dysplasia (BPD; group BPD), and infants without BPD who had a birth weight (BW) <750 g, or clinical suspicion for PH (group NoBPD). RESULTS: Two hundred and four infants were screened (GA 25...
February 16, 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/28190975/reduced-platelet-hyper-reactivity-and-platelet-leukocyte-aggregation-after-periodontal-therapy
#2
Efthymios Arvanitidis, Sergio Bizzarro, Elena Alvarez Rodriguez, Bruno G Loos, Elena A Nicu
BACKGROUND: Platelets from untreated periodontitis patients are hyper-reactive and form more platelet-leukocyte complexes compared to cells from individuals without periodontitis. It is not known whether the improvement of the periodontal condition achievable by therapy has beneficial effects on the platelet function. We aimed to assess the effects of periodontal therapy on platelet reactivity. METHODS: Patients with periodontitis (n = 25) but unaffected by any other medical condition or medication were included and donated blood before and after periodontal therapy...
2017: Thrombosis Journal
https://www.readbyqxmd.com/read/28139937/risk-factors-for-tracheostomy-requirement-in-extremely-low-birth-weight-infants
#3
Orly L Levit, Veronika Shabanova, Alia Bazzy-Asaad, Matthew J Bizzarro, Vineet Bhandari
AIM: To identify variables that affect the risk for tracheostomy in a population of extremely low birth weight (ELBW) infants. METHODS: A retrospective matched case-control study was conducted. ELBW infants with a tracheostomy were compared with controls without tracheostomy. Data collection included demographics, detailed information about each intubation and extubation attempt, the use of steroids and the presence of comorbidities. Statistical analyses include conditional logistic regression and Poisson regression for clustered observations...
January 31, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28099523/the-role-of-liquid-based-cytology-and-ancillary-techniques-in-the-peritoneal-washing-analysis-our-institutional-experience
#4
Esther Rossi, Tommaso Bizzarro, Maurizio Martini, Adhemar Longatto-Filho, Fernando Schmitt, Anna Fagotti, Giovanni Scambia, Gian Franco Zannoni
BACKGROUND: The cytological analysis of peritoneal effusions serves as a diagnostic and prognostic aid for either primary or metastatic diseases. Among the different cytological preparations, liquid based cytology (LBC) represents a feasible and reliable method ensuring also the application of ancillary techniques (i.e immunocytochemistry-ICC and molecular testing). METHODS: We recorded 10348 LBC peritoneal effusions between January 2000 and December 2014. They were classified as non-diagnostic (ND), negative for malignancy-NM, atypical-suspicious for malignancy-SM and positive for malignancy-PM...
2017: PloS One
https://www.readbyqxmd.com/read/28041971/clinicopathological-analysis-of-mixed-endometrial-carcinomas-clinical-relevance-of-different-neoplastic-components
#5
Esther Diana Rossi, Tommaso Bizzarro, Giorgia Monterossi, Frediano Inzani, Francesco Fanfani, Giovanni Scambia, Gian Franco Zannoni
Mixed endometrial carcinomas (MEC) refer to tumors characterized by 2 or more distinct histotypes mostly comprised of endometrioid (EC) and serous /clear cell carcinomas (SC/CC). The specific quantification of these distinct components represents a challenging and critical point for both prognosis and management. Herein, we analyze a large series of MEC and compare them with EC and SC/CC. We evaluated a series of 69 MEC between January 2002 and December 2015. We compared the MEC series with 186 EC (including 117 endometrioid G3), 31 SC and 38 CC...
December 29, 2016: Human Pathology
https://www.readbyqxmd.com/read/28001329/fna-biopsy-of-secondary-nonlymphomatous-malignancies-in-salivary-glands-a-multi-institutional-study-of-184-cases
#6
He Wang, Raza S Hoda, William Faquin, Esther Diana Rossi, Nihar Hotchandani, Tianlin Sun, Marc Pusztaszeri, Tommaso Bizzarro, Massimo Bongiovanni, Viren Patel, Nirag Jhala, Guido Fadda, Yun Gong
BACKGROUND: Secondary malignancies of salivary glands (SMSGs) are among the most common malignant neoplasms to involve the salivary glands. Fine-needle aspiration biopsy (FNAB) of SMSG can present diagnostic challenges. The current report presents the largest such FNAB series to date. METHODS: A search of the pathology database from 6 academic institutions identified 184 FNAB cases of nonlymphomatous SMSG. RESULTS: Of the 184 cases, 171 were of the parotid glands, and 13 were of the submandibular glands; 130 patients were men, and 54 were women, and the mean patient age at diagnosis was 68 years...
December 21, 2016: Cancer
https://www.readbyqxmd.com/read/27966635/boosting-adaptive-immunity-a-new-role-for-pafr-antagonists
#7
Marianna M Koga, Bruna Bizzarro, Anderson Sá-Nunes, Francisco J Rios, Sonia Jancar
We have previously shown that the Platelet-Activating Factor Receptor (PAFR) engagement in murine macrophages and dendritic cells (DCs) promotes a tolerogenic phenotype reversed by PAFR-antagonists treatment in vitro. Here, we investigated whether a PAFR antagonist would modulate the immune response in vivo. Mice were subcutaneously injected with OVA or OVA with PAFR-antagonist WEB2170 on days 0 and 7. On day 14, OVA-specific IgG2a and IgG1 were measured in the serum. The presence of WEB2170 during immunization significantly increased IgG2a without affecting IgG1 levels...
December 14, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27941541/cytopathology-of-follicular-cell-nodules
#8
REVIEW
Esther D Rossi, Tommaso Bizzarro, Maurizio Martini, Luigi M Larocca, Fernando Schmitt, Philippe Vielh
The detection of thyroid nodules, consisting of different diseases, represents a common finding in population. Their evaluation and diagnosis are mostly achieved with fine-needle aspiration cytology (FNAC). Even though the majority of thyroid nodules are correctly diagnosed, a total of 25% to 30% of them are classified "indeterminate" comprising lesions with varying risk of malignancy and different types of management. Although the number of thyroid FNACs, including small lesions, is increasing due to the reliance upon sonographic and cytologic interpretations, there are issues concerning cytomorphologic interpretation and interobserver reproducibility...
January 2017: Advances in Anatomic Pathology
https://www.readbyqxmd.com/read/27850544/906-determination-of-indication-based-extended-interval-gentamicin-dosing-regimens-for-neonates
#9
Michelle Rychalsky, Meghan Rowcliffe, Jessica Vital-Carona, Laura Broome, Sarah Kelly, Matthew Bizzarro
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27834582/hypoxia-regulates-anxa1-expression-to-support-prostate-cancer-cell-invasion-and-aggressiveness
#10
Valentina Bizzarro, Raffaella Belvedere, Vincenzo Migliaro, Elena Romano, Luca Parente, Antonello Petrella
Annexin A1 (ANXA1) is a Ca(2+)-binding protein overexpressed in the invasive stages of prostate cancer (PCa) development; however, its role in this tumor metastatization is largely unknown. Moreover, hypoxic conditions in solid tumors have been related to poor prognosis in PCa patients. We have previously demonstrated that ANXA1 is implicated in the acquisition of chemo-resistant features in DU145 PCa cells conferring them a mesenchymal/metastatic phenotype. In this study, we have investigated the mechanisms by which ANXA1 regulates metastatic behavior in LNCaP, DU145 and PC3 cells exposed to hypoxia...
November 11, 2016: Cell Adhesion & Migration
https://www.readbyqxmd.com/read/27738305/somatic-mutations-in-solid-tumors-a-spectrum-at-the-service-of-diagnostic-armamentarium-or-an%C3%A2-indecipherable-puzzle-the-morphological-eyes-looking-for-braf-and-somatic-molecular-detections-on-cyto-histological-samples
#11
REVIEW
Esther Diana Rossi, Maurizio Martini, Tommaso Bizzarro, Fernando Schmitt, Adhemar Longatto-Filho, Luigi Maria Larocca
This review article deals with the analysis and the detection of the morphological features associated with somatic mutations, mostly BRAFV600E mutation, on both cytological and histological samples of carcinomas. Few authors demonstrated that some architectural and specific cellular findings (i.e. polygonal eosinophilic cells defined as "plump cells" and sickle-shaped nuclei) are able to predict BRAF V600E mutation in both cytological and histological samples of papillary thyroid carcinoma (PTC) as well as in other carcinomas...
January 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/27717284/young-investigator-challenge-the-morphologic-analysis-of-noninvasive-follicular-thyroid-neoplasm-with-papillary-like-nuclear-features-on-liquid-based-cytology-some-insights-into-their-identification
#12
Tommaso Bizzarro, Maurizio Martini, Sara Capodimonti, Patrizia Straccia, Celestino Pio Lombardi, Alfredo Pontecorvi, Luigi Maria Larocca, Esther Diana Rossi
BACKGROUND: Noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) represents a challenge for the diagnosis and management of thyroid carcinoma. Some authors have proposed histological criteria that are able to distinguish NIFTPs from invasive follicular variant of papillary thyroid carcinoma (I-FVPTC). Hence, NIFTPs may have repercussions in the diagnostic categories on fine-needle aspiration. In the current study, the authors evaluated the criteria for NIFTPs on liquid-based cytology samples...
October 2016: Cancer
https://www.readbyqxmd.com/read/27634418/patient-with-rapidly-evolving-neurological-disease-with-neuropathological-lesions-of-creutzfeldt-jakob-disease-lewy-body-dementia-chronic-subcortical-vascular-encephalopathy-and-meningothelial-meningioma
#13
Maria Gabriella Vita, Dorina Tiple, Alessandra Bizzarro, Anna Ladogana, Elisa Colaizzo, Sabina Capellari, Marcello Rossi, Piero Parchi, Carlo Masullo, Maurizio Pocchiari
We report a case of rapidly evolving neurological disease in a patient with neuropathological lesions of Creutzfeldt-Jakob disease (CJD), Lewy body dementia (LBD), chronic subcortical vascular encephalopathy and meningothelial meningioma. The coexistence of severe multiple pathologies in a single patient strengthens the need to perform accurate clinical differential diagnoses in rapidly progressive dementias.
September 16, 2016: Neuropathology: Official Journal of the Japanese Society of Neuropathology
https://www.readbyqxmd.com/read/27627668/what-s-growing-on-general-practitioner-s-stethoscope
#14
A Carducci, M Cargnelutti, F Tassinari, A Bizzarro, G Cordio, S Carletti, L Maccarini, G Pelissero
BACKGROUND: Non-critical medical devices, as stethoscopes, have long been considered as vectors in microorganisms' transmission. Cleaning standards for non-critical medical equipment are often unclear. This study was designed to assess the attitude of General Practitioners (GPs) towards cleaning their stethoscope and the degree of microbiological contamination of doctor's instrument in outpatient setting. STUDY DESIGN: Observational, crossover study. METHODS: A structured questionnaire was administered to GPs to test their knowledge about medical instrument's cleanliness recommendations and the surface of the diaphragm of their stethoscopes was analyzed for bacteriological isolates using mass spectrometry technique...
September 2016: Annali di Igiene: Medicina Preventiva e di Comunità
https://www.readbyqxmd.com/read/27563152/magnesium-and-54-cr-isotope-compositions-of-carbonaceous-chondrite-chondrules-insights-into-early-disk-processes
#15
Mia B Olsen, Daniel Wielandt, Martin Schiller, Elishevah M M E Van Kooten, Martin Bizzarro
We report on the petrology, magnesium isotopes and mass-independent (54)Cr/(52)Cr compositions (μ(54)Cr) of 42 chondrules from CV (Vigarano and NWA 3118) and CR (NWA 6043, NWA 801 and LAP 02342) chondrites. All sampled chondrules are classified as type IA or type IAB, have low (27)Al/(24)Mg ratios (0.04-0.27) and display little or no evidence for secondary alteration processes. The CV and CR chondrules show variable (25)Mg/(24)Mg and (26)Mg/(24)Mg values corresponding to a range of mass-dependent fractionation of ~500 ppm (parts per million) per atomic mass unit...
October 15, 2016: Geochimica et Cosmochimica Acta
https://www.readbyqxmd.com/read/27558677/benzodiazepine-scaffold-as-drug-like-molecular-simplification-of-fr235222-a-chemical-tool-for-exploring-hdac-inhibition
#16
Rosario Randino, Ilaria Moronese, Elena Cini, Valentina Bizzarro, Marco Persico, Manuela Grimaldi, Mario Scrima, Anna Maria D'Ursi, Ettore Novellino, Eduardo Sobarzo-Sanchez, Luca Rastrelli, Caterina Fattorusso, Antonello Petrella, Manuela Rodriquez, Maurizio Taddei
BACKGROUND: Synthesis, computational study and biological evaluation of peptidomimetic analogues of FR235222 (3), a natural immunosuppressant and HDAC inhibitor, have been reported. These new compounds, bearing α-hydroxyketone moiety, as more stable zinc binding group (ZBG), were evaluated in vitro as HDAC inhibitors against the human HDACs isoforms 1-9 and in cellular antiproliferative assays on U937 human leukemia cell line. The 1,4-benzodiazepin-2,5-dione (BDZ), capping group and the natural ZBG, (S,R)-2-amino-9-hydroxy-8-oxodecanoic acid (Ahoda), were evaluated in order to probe HDAC inhibition and/or paralogue selectivity...
2017: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/27503372/revisitation-of-autoimmune-hypophysitis-knowledge-and-uncertainties-on-pathophysiological-and-clinical-aspects
#17
REVIEW
Giuseppe Bellastella, Maria Ida Maiorino, Antonio Bizzarro, Dario Giugliano, Katherine Esposito, Antonio Bellastella, Annamaria De Bellis
PURPOSE: This publication reviews the accepted knowledges and the findings still discussed on several features of autoimmune hypophysitis, including the most recently described forms, such as IgG4 and cancer immunotherapy- related hypophysitis. METHODS: The most characteristic findings and the pending controversies were derived from a literature review and previous personal experiences. A single paragraph focused on some atypical examples of the disease presenting under confounding pretences...
December 2016: Pituitary
https://www.readbyqxmd.com/read/27484771/the-expression-of-monocarboxylate-transporters-in-thyroid-carcinoma-can-be-associated-with-the-morphological-features-of-braf-v600e-mutation
#18
Esther Diana Rossi, Tommaso Bizzarro, Sara Granja, Maurizio Martini, Sara Capodimonti, Emilia Luca, Guido Fadda, Celestino Pio Lombardi, Alfredo Pontecorvi, Luigi Maria Larocca, Fatima Baltazar, Fernando Schmitt
BRAF (V600E) mutation, usually performed by DNA techniques, is one of the most common diagnostic markers in papillary thyroid carcinoma. Few papers have demonstrated that plump cells (eosinophilic cytoplasms and papillary thyroid carcinoma nuclei) and peculiar sickle-shaped nuclei represent morphological features of BRAF (V600E) on papillary thyroid carcinomas. These features seem to be linked to glycolytic phenotype whereby monocarboxylate transporters 1-4 are hypothesized to have a dominant role as lactate transporters...
August 2, 2016: Endocrine
https://www.readbyqxmd.com/read/27445452/tungsten-isotopes-in-bulk-meteorites-and-their-inclusions-implications-for-processing-of-presolar-components-in-the-solar-protoplanetary-disk
#19
J C Holst, C Paton, D Wielandt, M Bizzarro
We present high precision, low- and high-resolution tungsten isotope measurements of iron meteorites Cape York (IIIAB), Rhine Villa (IIIE), Bendego (IC), and the IVB iron meteorites Tlacotepec, Skookum, and Weaver Mountains, as well as CI chondrite Ivuna, a CV3 chondrite refractory inclusion (CAI BE), and terrestrial standards. Our high precision tungsten isotope data show that the distribution of the rare p-process nuclide (180)W is homogeneous among chondrites, iron meteorites, and the refractory inclusion...
September 3, 2015: Meteoritics & Planetary Science
https://www.readbyqxmd.com/read/27445415/accretion-timescales-and-style-of-asteroidal-differentiation-in-an-26-al-poor-protoplanetary-disk
#20
K K Larsen, M Schiller, M Bizzarro
The decay of radioactive (26)Al to (26)Mg (half-life of 730,000 years) is postulated to have been the main energy source promoting asteroidal melting and differentiation in the nascent solar system. High-resolution chronological information provided by the (26)Al-(26)Mg decay system is, therefore, intrinsically linked to the thermal evolution of early-formed planetesimals. In this paper, we explore the timing and style of asteroidal differentiation by combining high-precision Mg isotope measurements of meteorites with thermal evolution models for planetesimals...
March 1, 2016: Geochimica et Cosmochimica Acta
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