keyword
https://read.qxmd.com/read/38447639/use-of-intravenous-albumin-a-guideline-from-the-international-collaboration-for-transfusion-medicine-guidelines
#21
Jeannie Callum, Nikolaos J Skubas, Aarti Bathla, Homa Keshavarz, Edward G Clark, Bram Rochwerg, Dean Fergusson, Sesmu Arbous, Seth R Bauer, Louise China, Mark Fung, Rachel Jug, Michael Neill, Cary Paine, Katerina Pavenski, Prakesh S Shah, Susan Robinson, Hua Shan, Zbigniew M Szczepiorkowski, Thierry Thevenot, Bovey Wu, Simon Stanworth, Nadine Shehata
BACKGROUND: Albumin is commonly employed across a wide range of clinical settings to improve hemodynamics, facilitate fluid removal, and manage complications of cirrhosis. The International Collaboration for Transfusion Medicine Guidelines developed guidelines for the use of albumin in patients requiring critical care, undergoing cardiovascular surgery, kidney replacement therapy, or experiencing complications of cirrhosis. METHODS: Co-chairs oversaw the guideline development process and the panel included researchers, clinicians, methodologists, and a patient representative...
March 4, 2024: Chest
https://read.qxmd.com/read/38442923/-review-and-prospects-of-international-clinical-research-in-critical-care-medicine-in-2023
#22
JOURNAL ARTICLE
Ziqi Rong, Pengyu Lu, Wei Huang
The main clinical research advances of critical care in 2023 includes: new trials of Chinese herbal medicine, hydroxocobalamin (vitamin B12), methylene blue as well glucocorticoids have shown the potential to improve outcomes of patients with sepsis and septic shock; international committees launched new global definition and managing recommendations for acute respiratory distress syndrome (ARDS). Besides, a cluster of new evidences has emerged in many aspects as following: fluid control strategy in sepsis (restrictive/liberative), antibiotic infusion strategy (continuous/intermittent), oxygen-saturation targets for mechanical ventilation (conservative/liberative), blood pressure targets after resuscitation from out-of-hospital cardiac arrest (hypotension/hypertension), blood pressure targets after successful stroke thrombectomy (intensive/conventional), and nutritional support strategies (low protein-calories/conventional protein-calories, fasting/persistent feeding before extubation)...
February 2024: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://read.qxmd.com/read/38436726/factors-associated-with-successful-liberation-from-continuous-renal-replacement-therapy-in-children-and-young-adults-analysis-of-the-worldwide-exploration-of-renal-replacement-outcomes-collaborative-in-kidney-disease-registry
#23
JOURNAL ARTICLE
Erin K Stenson, Issa Alhamoud, Rashid Alobaidi, Gabriella Bottari, Sarah Fernandez, Dana Y Fuhrman, Francesco Guzzi, Taiki Haga, Ahmad Kaddourah, Eleonora Marinari, Tahagod Mohamed, Catherine Morgan, Theresa Mottes, Tara Neumayr, Nicholas J Ollberding, Valeria Raggi, Zaccaria Ricci, Emily See, Natalja L Stanski, Huaiyu Zang, Emily Zangla, Katja M Gist
PURPOSE: Continuous renal replacement therapy (CRRT) is used for supportive management of acute kidney injury (AKI) and disorders of fluid balance (FB). Little is known about the predictors of successful liberation in children and young adults. We aimed to identify the factors associated with successful CRRT liberation. METHODS: The Worldwide Exploration of Renal Replacement Outcomes Collaborative in Kidney Disease study is an international multicenter retrospective study (32 centers, 7 nations) conducted from 2015 to 2021 in children and young adults (aged 0-25 years) treated with CRRT for AKI or FB disorders...
March 4, 2024: Intensive Care Medicine
https://read.qxmd.com/read/38434615/neuroinvasive-bacillus-cereus-infection-in-immunocompromised-hosts-epidemiologic-investigation-of-5-patients-with-acute-myeloid-leukemia
#24
JOURNAL ARTICLE
Jessica S Little, Cassie Coughlin, Candace Hsieh, Meaghan Lanza, Wan Yi Huang, Aishwarya Kumar, Tanvi Dandawate, Robert Tucker, Paige Gable, Axel A Vazquez Deida, Heather Moulton-Meissner, Valerie Stevens, Gillian McAllister, Thomas Ewing, Maria Diaz, Janet Glowicz, Marisa L Winkler, Nicole Pecora, David W Kubiak, Jeffrey C Pearson, Marlise R Luskin, Amy C Sherman, Ann E Woolley, Christina Brandeburg, Barbara Bolstorff, Eileen McHale, Esther Fortes, Matthew Doucette, Sandra Smole, Craig Bunnell, Anne Gross, Dana Platt, Sonali Desai, Karen Fiumara, Nicolas C Issa, Lindsey R Baden, Chanu Rhee, Michael Klompas, Meghan A Baker
BACKGROUND: Bacillus cereus is a ubiquitous gram-positive rod-shaped bacterium that can cause sepsis and neuroinvasive disease in patients with acute leukemia or neutropenia. METHODS: A single-center retrospective review was conducted to evaluate patients with acute leukemia, positive blood or cerebrospinal fluid test results for B cereus , and abnormal neuroradiographic findings between January 2018 and October 2022. Infection control practices were observed, environmental samples obtained, a dietary case-control study completed, and whole genome sequencing performed on environmental and clinical Bacillus isolates...
March 2024: Open Forum Infectious Diseases
https://read.qxmd.com/read/38430893/refractory-chylous-ascites-revealing-follicular-lymphoma-a-case-report
#25
Yassine Tlili, Zied Hadrich, Montacer Hafsi, Omrani Sahir, Bayar Rached, Hafedh Mestiri
INTRODUCTION AND IMPORTANCE: Chylous ascites is an uncommon form of ascites characterized by milky fluid rich in triglycerides. It is associated with poor lymphatic drainage. We report a case of chylous ascites revealing a follicular lymphoma. CASE PRESENTATION: A 73-year-old man presented with a 6-month history of abdominal distension attributed to a chylous ascitis. The thoraco-abdomino-pelvic CT scan revealed voluminous intra- and retroperitoneal mass inseparable from the duodeno-pancreatic block and encompassing the mesenteric vessels, inferior vena cava and renal vessels; abundant ascites and multiple mediastinal, coeliomesenteric, retroperitoneal, iliac and inguinal adenomegalia...
February 23, 2024: International Journal of Surgery Case Reports
https://read.qxmd.com/read/38425592/ascitic-fluid-lactate-level-as-a-predictor-of-mortality-in-cirrhotic-patients-having-spontaneous-bacterial-peritonitis-sbp
#26
JOURNAL ARTICLE
Danish Kumar, Raja Taha Yaseen, Muhammad Qaiser Panezai, Muhammad Usman Naeem, Hina Ismail, Zain Majid, Nasir Mehmood, Muhammad Ali Khalid, Ghulamullah Lail, Nasir Hassan Luck
Introduction Limited studies are available for predicting mortality in patients with spontaneous bacterial peritonitis (SBP) based on ascitic fluid analysis. Recently, a proposition has been made regarding the role of ascitic fluid lactate as a better prognostic indicator of mortality in cirrhotic patients with SBP. Therefore, we aimed to evaluate the utility of ascitic fluid lactate in predicting mortality in cirrhotic patients with SBP. Methods This was a prospective, observational study that was conducted in the Hepato-Gastroenterology Department of Sindh Institute of Urology and Transplantation (SIUT), Karachi from 1 January 2022 to 31 December 2022...
January 2024: Curēus
https://read.qxmd.com/read/38424519/risk-factors-of-multidrug-resistant-organisms-neonatal-sepsis-in-surabaya-tertiary-referral-hospital-a-single-center-study
#27
JOURNAL ARTICLE
Stefani Miranda, Aminuddin Harahap, Dominicus Husada, Fara Nayo Faramarisa
BACKGROUND: Bacterial organisms causing neonatal sepsis have developed increased resistance to commonly used antibiotics. Antimicrobial resistance is a major global health problem. The spread of Multidrug-Resistant Organisms (MDROs) is associated with higher morbidity and mortality rates. This study aimed to determine the risk factors for developing MDRO neonatal sepsis in the Neonatal Intensive Care Unit (NICU), dr. Ramelan Navy Central Hospital, in 2020-2022. METHODS: A cross-sectional study was performed on 113 eligible neonates...
February 29, 2024: BMC Pediatrics
https://read.qxmd.com/read/38419918/isolated-ocular-relapse-of-acute-myeloid-leukaemia-post-allogeneic-stem-cell-transplant
#28
M H Tong, A Kwok, A Walsh, P Heydon, E S Koh, N McNamara, A Bryant
We present a rare case of a 39-year-old female with extramedullary relapse of acute myeloid leukaemia (AML) isolated to the left eye 2 months post allogeneic haematopoietic stem cell transplant. She initially presented with painless left eye erythema, swelling, and visual impairment. Initial ophthalmology review revealed conjunctival chemosis, raised intraocular pressure, and serous retinal detachments. She was initially treated for suspected orbital cellulitis with intravenous antibiotic and antifungal therapy but clinically progressed so was then treated with intravenous corticosteroids...
2024: Case Reports in Ophthalmological Medicine
https://read.qxmd.com/read/38418899/sex-differences-in-in-hospital-management-in-patients-with-sepsis-and-septic-shock-a-prospective-multicenter-observational-study
#29
MULTICENTER STUDY
Sejoong Ahn, Bo-Yeong Jin, Sukyo Lee, Sungjin Kim, Sungwoo Moon, Hanjin Cho, Kap Su Han, You Hwan Jo, Kyuseok Kim, Jonghwan Shin, Gil Joon Suh, Woon Yong Kwon, Tae Gun Shin, Han Sung Choi, Sangchun Choi, Yoo Seok Park, Sung Phil Chung, Won Young Kim, Hong Joon Ahn, Tae Ho Lim, Sung-Hyuk Choi, Jong-Hak Park
Sex differences in the in-hospital management of sepsis exist. Previous studies either included patients with sepsis that was defined using previous definitions of sepsis or evaluated the 3-h bundle therapy. Therefore, this study sought to assess sex differences in 1-h bundle therapy and in-hospital management among patients with sepsis and septic shock, defined according to the Sepsis-3 definitions. This observational study used data from Korean Shock Society (KoSS) registry, a prospective multicenter sepsis registry...
February 28, 2024: Scientific Reports
https://read.qxmd.com/read/38415021/sequential-extracorporeal-therapy-of-pathogen-removal-followed-by-cell-directed-extracorporeal-therapy-in-streptococcal-toxic-shock-syndrome-refractory-to-venoarterial-extracorporeal-membrane-oxygenation-a-case-report
#30
Stephen J Amerson, McKenna Hoffman, Fadi Abouzahr, Mohammad Ahmad, Rachel K Sterling, Hitesh Gidwani, Linda E Sousse, Jeffrey D Dellavolpe
BACKGROUND: Streptococcal toxic shock syndrome (STSS) is a fulminant complication of predominantly invasive group A streptococcal infections. STSS is often characterized by influenza-like symptoms, including fever, chills, and myalgia that can quickly progress to sepsis with hypotension, tachycardia, tachypnea, and multiple organ failure (kidney, liver, lung, or blood). Mortality can exceed 50% depending on the severity of symptoms. CASE SUMMARY: Here, we describe a novel, multi-extracorporeal intervention strategy in a case of severe septic shock secondary to STSS...
March 2024: Critical care explorations
https://read.qxmd.com/read/38412124/claudin-2-upregulation-enhances-intestinal-permeability-immune-activation-dysbiosis-and-mortality-in-sepsis
#31
JOURNAL ARTICLE
Takehiko Oami, Shabnam Abtahi, Takashi Shimazui, Ching-Wen Chen, Yan Y Sweat, Zhe Liang, Eileen M Burd, Alton B Farris, Joe T Roland, Sachiko Tsukita, Mandy L Ford, Jerrold R Turner, Craig M Coopersmith
Intestinal epithelial expression of the tight junction protein claudin-2, which forms paracellular cation and water channels, is precisely regulated during development and in disease. Here, we show that small intestinal epithelial claudin-2 expression is selectively upregulated in septic patients. Similar changes occurred in septic mice, where claudin-2 upregulation coincided with increased flux across the paracellular pore pathway. In order to define the significance of these changes, sepsis was induced in claudin-2 knockout (KO) and wild-type (WT) mice...
March 5, 2024: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/38403808/pattern-of-fluid-overload-and-its-impact-on-mortality-among-mechanically-ventilated-children-secondary-analysis-of-the-relisch-trial
#32
JOURNAL ARTICLE
Shubham Charaya, Suresh Kumar Angurana, Karthi Nallasamy, Arun Bansal, Jayashree Muralidharan
OBJECTIVES: To assess the pattern of fluid overload (FO) and its impact on mortality among mechanically ventilated children. METHODS: In this secondary analysis of an open-label randomized controlled trial (ReLiSCh trial, October 2020-September 2021), hemodynamically stable mechanically ventilated children (n = 100) admitted to a tertiary level pediatric intensive care unit (PICU) in North India were enrolled. The primary outcome was pattern of FO (FO% >10% and cumulative FO% from day 1-7); and secondary outcomes were pattern of FO among survivors and non-survivors, and prescription practices of maintenance fluid...
February 26, 2024: Indian Journal of Pediatrics
https://read.qxmd.com/read/38403742/association-between-intravenous-fluid-administration-and-endothelial-glycocalyx-shedding-in-humans-a-systematic-review
#33
REVIEW
Sara Sukudom, Lisa Smart, Stephen Macdonald
INTRODUCTION: Several studies have demonstrated associations between greater rate/volume of intravenous (IV) fluid administration and poorer clinical outcomes. One postulated mechanism for harm from exogenous fluids is shedding of the endothelial glycocalyx (EG). METHODS: A systematic review using relevant search terms was performed using Medline, EMBASE and Cochrane databases from inception to October 2023. Included studies involved humans where the exposure was rate or volume of IV fluid administration and the outcome was EG shedding...
February 26, 2024: Intensive Care Medicine Experimental
https://read.qxmd.com/read/38403429/appraisal-of-australian-and-new-zealand-paediatric-sepsis-guidelines
#34
JOURNAL ARTICLE
Rosemary Sasse, Meredith L Borland, Shane George, Shefali Jani, Eunicia Tan, Jocelyn Neutze, Natalie Phillips, Amit Kochar, Simon Craig, Anna Lithgow, Arjun Rao, Stuart R Dalziel, Amanda Williams, Franz E Babl, Grace Went, Elliot Long
OBJECTIVE: Clinical practice guidelines (CPGs) are an important tool for the management of children with sepsis. The quality, consistency and concordance of Australian and New Zealand (ANZ) childhood sepsis CPGs with the Australian Commission on Safety and Quality in Healthcare (ACSQHC) sepsis clinical care standards and international sepsis guidelines is unclear. METHODS: We accessed childhood sepsis CPGs for all ANZ states and territories through Paediatric Research in Emergency Departments International Collaborative members...
February 25, 2024: Emergency Medicine Australasia: EMA
https://read.qxmd.com/read/38400847/tomatidine-activates-autophagy-to-improve-lung-injury-and-inflammation-in-sepsis-by-inhibiting-nf-%C3%AE%C2%BAb-and-mapk-pathways
#35
JOURNAL ARTICLE
Bo Xu, Min Huang, Hang Qi, Hongzhou Xu, Liang Cai
Sepsis-induced acute lung injury (ALI) is a life-threatening medical condition with high mortality and morbidity. Autophagy is involved in the pathophysiological process of sepsis-induced ALI, including inflammation, which indicates that regulating autophagy may be beneficial for this disease. Tomatidine, a natural compound abundant in unripe tomatoes, has been reported to have anti-inflammatory, anti-tumorigenic, and lipid-lowering effects. However, the biological functions and mechanisms of tomatidine in sepsis-induced ALI remain unknown...
February 24, 2024: Molecular Genetics and Genomics: MGG
https://read.qxmd.com/read/38399580/perirectal-abscess-with-anterior-extension-to-the-extraperitoneum-and-space-of-retzius-a-case-report
#36
Hsiang Teng, Po-Hsien Wu
Introduction -This report illuminates the distinctive features of a successfully managed Retzius space infection arising from a complex perirectal abscess. It adds novel insights to the scientific literature by addressing the rarity of such occurrences, highlighting the diagnostic complexities associated with extraperitoneal spread, and underscoring the crucial role of a nuanced understanding of anatomy in navigating clinical scenarios involving anorectal abscesses. Patient's Main Concerns and Important Clinical Findings -A 68-year-old male presented with dizziness and diffuse lower abdominal pain, accompanied by intermittent perianal pain for one month...
February 8, 2024: Medicina
https://read.qxmd.com/read/38395221/cerebrospinal-fluid-inflammatory-markers-to-differentiate-between-neonatal-bacterial-meningitis-and-sepsis-a-prospective-study-of-diagnostic-accuracy
#37
JOURNAL ARTICLE
Nina S Groeneveld, Sabine E Olie, Douwe H Visser, Linde Snoek, Diederik van de Beek, Matthijs C Brouwer, Merijn W Bijlsma
OBJECTIVES: We evaluated the diagnostic accuracy of cerebrospinal fluid (CSF) inflammatory markers for diagnosing bacterial meningitis in neonates with sepsis and/or meningitis. METHODS: Cases were identified from a prospective multicenter study including patients aged 0-3 months with Group B Streptococcal (GBS) or Escherichia coli culture positive sepsis/meningitis. CSF CXCL-10, MDC, IL6, Il-8, IL-10, TNF- α, MIF, IL-1RA, CXCL13, IL-1β, CRP and procalcitonin concentrations were measured with Luminex technology...
February 21, 2024: International Journal of Infectious Diseases: IJID
https://read.qxmd.com/read/38394060/tau-and-a%C3%AE-42-in-lavage-fluid-of-pneumonia-patients-are-associated-with-end-organ-dysfunction-a-prospective-exploratory-study
#38
JOURNAL ARTICLE
Phoibe Renema, Jean-Francois Pittet, Angela P Brandon, Sixto M Leal, Steven Gu, Grace Promer, Andrew Hackney, Phillip Braswell, Andrew Pickering, Grace Rafield, Sarah Voth, Ron Balczon, Mike T Lin, K Adam Morrow, Jessica Bell, Jonathon P Audia, Diego Alvarez, Troy Stevens, Brant M Wagener
BACKGROUND: Bacterial pneumonia and sepsis are both common causes of end-organ dysfunction, especially in immunocompromised and critically ill patients. Pre-clinical data demonstrate that bacterial pneumonia and sepsis elicit the production of cytotoxic tau and amyloids from pulmonary endothelial cells, which cause lung and brain injury in naïve animal subjects, independent of the primary infection. The contribution of infection-elicited cytotoxic tau and amyloids to end-organ dysfunction has not been examined in the clinical setting...
2024: PloS One
https://read.qxmd.com/read/38392609/challenges-in-septic-shock-from-new-hemodynamics-to-blood-purification-therapies
#39
REVIEW
Fernando Ramasco, Jesús Nieves-Alonso, Esther García-Villabona, Carmen Vallejo, Eduardo Kattan, Rosa Méndez
Sepsis and septic shock are associated with high mortality, with diagnosis and treatment remaining a challenge for clinicians. Their management classically encompasses hemodynamic resuscitation, antibiotic treatment, life support, and focus control; however, there are aspects that have changed. This narrative review highlights current and avant-garde methods of handling patients experiencing septic shock based on the experience of its authors and the best available evidence in a context of uncertainty. Following the first recommendation of the Surviving Sepsis Campaign guidelines, it is recommended that specific sepsis care performance improvement programs are implemented in hospitals, i...
February 3, 2024: Journal of Personalized Medicine
https://read.qxmd.com/read/38389624/caudal-neuraxial-blocks-for-pain-relief-from-pelvic-neuropathy-caused-by-extensive-diffuse-large-b-cell-lymphoma
#40
Amanda Myles, Ammar Toubasi, Elizabeth Soladoye, Narayana Gowda, Joan Morny
Central neuraxial blocks can be a vital therapeutic tool for neuropathic pain, but they are infrequently implemented for pain management in cancer patients. Upon a literature review, further data on the role or efficacy of central nerve blocks for neuropathic cancer pain would be beneficial. Additionally, evidence-based guidelines and practices are lacking regarding additional interventions for neuropathic pain relief, a common manifestation of cancer burden. Here, we report the case of a 29-year-old male patient who presented in the ED with intractable neuropathic pain from extensive diffuse large B-cell lymphoma...
January 2024: Curēus
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