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Exvivo perfusion

J M Reis, A B Dezani, T M Pereira, A Avdeef, C H R Serra
In order to reach the bloodstream and thus the target receptor, an orally-administered drug must first cross the intestinal barrier, which can occur via a paracellular, passive transcellular, or carrier-mediated uptake and/or efflux process (active or concentration gradient-driven). Our work aimed to explore the transport mechanism of the antiretroviral lamivudine (deoxycytidine nucleoside analogue), using a three-part strategy: in vitro, an ex vivo and an in situ method, represented by PAMPA, rat jejunum patches and rat Single Pass Intestinal Perfusion (SPIP), respectively...
March 12, 2013: European Journal of Pharmaceutical Sciences
Ilhan Inci, Luca Ampollini, Stephan Arni, Wolfgang Jungraithmayr, Demet Inci, Sven Hillinger, Boris Leskosek, Peter Vogt, Walter Weder
BACKGROUND: Injured lungs due to gastric acid aspiration may be rejected for transplantation because of the possibility of early graft dysfunction. We hypothesized that diluted surfactant administration during ex vivo perfusion would recondition the lungs injured by acid aspiration and permit their use as suitable grafts for transplantation. METHODS: Using a pig model, lung injury was induced with 5-ml/kg administration of a betaine-HCl/pepsin mixture via a flexible bronchoscope...
November 2008: Journal of Heart and Lung Transplantation
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