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Oxygen Carrier

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https://www.readbyqxmd.com/read/29239956/the-anesthesia-workstation-quo-vadis
#1
Jan F A Hendrickx, Andre M De Wolf
Ensuring adequate ventilation and oxygenation and delivering inhaled anesthetic agent to the patient remain core responsibilities of the anesthesia provider during general anesthesia. Because of the emphasis placed on physiology, pharmacology, clinical sciences, and administrative duties, the stellar anesthesia workstation technology may be underutilized by the anesthesia community. Target-controlled O2 and agent delivery and automated end-expired CO2 control have entered the clinical arena, with only cost, luddism, and administrative hurdles preventing their more widespread use...
December 11, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29236476/oxygen-self-produced-nanoplatform-for-relieving-hypoxia-and-breaking-resistance-to-sonodynamic-treatment-of-pancreatic-cancer
#2
Jie Chen, Honglin Luo, Yan Liu, Wei Zhang, Hongxue Li, Tao Luo, Kun Zhang, Yongxiang Zhao, Junjie Liu
Hypoxia as one characteristic hallmark of solid tumors has been demonstrated to involve in cancer metastasis and progression, induce severe resistance to oxygen-dependent therapies and hamper the transportation of theranostic agents. To address these issues, an oxygen self-produced sonodynamic therapy (SDT) nanoplatform involving modified fluorocarbon (FC) chains-mediated oxygen delivery protocol has been established to realize highly-efficient SDT against hypoxic pancreatic cancer. In this nanoplatform, mesopores and FC chains of FC chains-functionalized hollow mesoporous organosilica nanoparticles (FHMONs) carriers can provide sufficient storage capacity and binding sites for sonosensitizers (IR780) and oxygen, respectively...
December 13, 2017: ACS Nano
https://www.readbyqxmd.com/read/29234759/a-sims-study-of-cation-and-anion-diffusion-in-tantalum-oxide
#3
U N Gries, H Schraknepper, K Skaja, F Gunkel, S Hoffmann-Eifert, R Waser, R A De Souza
Ion transport in ceramics of the low-temperature phase of tantalum pentoxide, L-Ta2O5, was examined by means of diffusion experiments and subsequent analysis of diffusion profiles with time-of-flight secondary ion mass spectrometry (ToF-SIMS). 18O/16O isotope anneals were used to investigate oxygen diffusion, and oxygen tracer diffusion coefficients were obtained for the temperature range of 623 ≤ T/K ≤ 873 at an oxygen partial pressure of pO2 = 0.2 bar and for the oxygen partial pressure range of 10-2 ≤ pO2/bar ≤ 100 at a temperature of T = 723 K...
December 13, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29230917/interfacial-nanoprecipitation-toward-stable-and-responsive-microbubbles-and-their-use-as-a-resuscitative-fluid
#4
Yifeng Peng, Raymond Seekell, Alexis Cole, Jemima Lamothe, Andrew Lock, Sarah van den Bosch, Xiaoqi Tang, John Kheir, Brian Polizzotti
We report a new approach to prepare stable microbubbles (MBs) via interfacial nanoprecipitation of bioabsorbable polymers at air/liquid interface. This facile method offers robust control over MBs morphology and chemo-physical properties by simple chemical modifications. This approach is amenable to large-scale manufacturing, and is useful to develop functional MBs for advanced biomedical applications. To demonstrate this, we created a MB-based intravenous oxygen carrier that undergoes pH-triggered self-elimination...
December 11, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/29229261/preliminary-experience-in-combined-somatic-and-cerebral-oximetry-monitoring-in-liver-transplantation
#5
Tina Hu, Yves Collin, Réal Lapointe, François Martin Carrier, Luc Massicotte, Annik Fortier, Jean Lambert, Franck Vandenbroucke-Menu, André Y Denault
OBJECTIVE: The use of cerebral near-infrared spectroscopy (NIRS) has become widespread in cardiac surgery after research demonstrated an association between perioperative cerebral desaturations and postoperative complications. Somatic NIRS desaturation also is associated with an increased risk of postoperative complications and mortality. The objective of this study was to explore the trends of both somatic and cerebral NIRS during liver transplantation. DESIGN: A prospective, single-site, observational case series...
July 20, 2017: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29227471/inhibiting-mitochondrial-phosphate-transport-as-an-unexploited-antifungal-strategy
#6
Catherine A McLellan, Benjamin M Vincent, Norma V Solis, Alex K Lancaster, Lucas B Sullivan, Cathy L Hartland, Willmen Youngsaye, Scott G Filler, Luke Whitesell, Susan Lindquist
The development of effective antifungal therapeutics remains a formidable challenge because of the close evolutionary relationship between humans and fungi. Mitochondrial function may present an exploitable vulnerability because of its differential utilization in fungi and its pivotal roles in fungal morphogenesis, virulence, and drug resistance already demonstrated by others. We now report mechanistic characterization of ML316, a thiohydantoin that kills drug-resistant Candida species at nanomolar concentrations through fungal-selective inhibition of the mitochondrial phosphate carrier Mir1...
December 11, 2017: Nature Chemical Biology
https://www.readbyqxmd.com/read/29226670/carrier-trapping-by-oxygen-impurities-in-molybdenum-diselenide
#7
Ke Chen, Anupam Roy, Amritesh Rai, Amithraj Valsaraj, Xianghai Meng, Feng He, Xiaochuan Xu, Leonard Frank Register, Sanjay K Banerjee, Yaguo Wang
Understanding defect effect on carrier dynamics is essential for both fundamental physics and potential applications of transition metal dichalcogenides. Here, the phenomenon of oxygen impurities trapping photo-excited carriers has been studied with ultrafast pump-probe spectroscopy. Oxygen impurities are intentionally created in exfoliated multilayer MoSe2 with Ar+ plasma irradiation and air exposure. After plasma treatment, the signal of transient absorption first increases and then decreases, which is a signature of defect capturing carriers...
December 11, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29223825/theranostic-liposomes-as-a-bimodal-carrier-for-magnetic-resonance-imaging-contrast-agent-and-photosensitizer
#8
Paulina Skupin-Mrugalska, Lukasz Sobotta, Alicja Warowicka, Beata Wereszczynska, Tomasz Zalewski, Piotr Gierlich, Marcin Jarek, Grzegorz Nowaczyk, Marek Kempka, Jacek Gapinski, Stefan Jurga, Jadwiga Mielcarek
The present study is focused on the development of liposomes bearing gadolinium chelate (GdLip) providing two functionalities for magnetic resonance imaging (MRI) and photodynamic therapy of cancer. A lipid derivative of gadolinium(III) diethylenetriamine pentaacetic acid salt (GdDTPA1) was inserted in the liposomal membrane and served as MRI contrast agent whereas a zinc phthalocyanine (ZnPc) was used as a model photosensitizer. In addition to conventional liposomes, pegylated lipids were used for the preparation of "stealth" liposomes...
December 2, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/29223531/self-assembly-regulated-anticancer-activity-of-platinum-coordinated-selenomethionine
#9
Tianyu Li, Wentian Xiang, Feng Li, Huaping Xu
It is urgently desired that self-assembly methods can be used to develop smart nanomedicines with adjustable anticancer activity and concise structure. Herein, we design carrier-free small molecule assemblies of platinum coordinated selenomethionine, which exhibit adjustable anticancer activity regulated by their self-assembly behaviors. The small molecule assemblies are prepared by coordination of selenomethionine esters with cisplatin. Their self-assembly behaviors can be tuned by esterification between selenomethionine and alcohols with different alkyl lengths, which results in adjustable anticancer activities...
December 5, 2017: Biomaterials
https://www.readbyqxmd.com/read/29215714/photobiomodulation-of-mesenchymal-stem-cells-encapsulated-in-an-injectable-rhbmp4-loaded-hydrogel-directs-hard-tissue-bioengineering
#10
Ivana Márcia Alves Diniz, Ana Cláudia O Carreira, Carla Renata Sipert, Cindi Mie Uehara, Maria Stella Nunes Moreira, Laila Freire, Cibele Pelissari, Patrícia M Kossugue, Daniele Ribeiro de Araújo, Mari Cleide Sogayar, Márcia Martins Marques
Photobiomodulation (PBM) therapy displays relevant properties for tissue healing and regeneration, which may be of interest for the tissue engineering field. Here, we show that PBM is able to improve cell survival and to interact with recombinant human Bone Morphogenetic Protein 4 (rhBMP4) to direct and accelerate odonto/osteogenic differentiation of dental derived mesenchymal stem cells (MSCs). MSCs were encapsulated in an injectable and thermo-responsive cell carrier (Pluronic® F-127) loaded with rhBMP4 and then photoactivated...
December 7, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29213118/vitamin-k2-prevents-lymphoma-in-drosophila
#11
Maytham A Dragh, Zhiliang Xu, Zainab S Al-Allak, Ling Hong
Previous studies have established the anticancer effect of vitamin K2 (VK2). However, its effect on lymphoma induced by UBIAD1/heix mutation in Drosophila remains unknown. Therefore, we aimed to develop an in vivo model of lymphoma for the precise characterization of lymphoma phenotypes. We also aimed to improve the understanding of the mechanisms that underlie the preventative effects of VK2 on lymphoma. Our results demonstrated that VK2 prevents lymphoma by acting as an electron carrier and by correcting the function and structure of mitochondria by inhibiting mitochondrial reactive oxygen species production mtROS...
December 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29210417/reactive-oxygen-species-ros-responsive-nanomedicine-for-rnai-based-cancer-therapy
#12
Yang Li, Hongzhen Bai, Hebin Wang, Youqing Shen, Guping Tang, Yuan Ping
Although much effort has been dedicated to the development of efficient siRNA delivery for cancer therapy, delivery nanomaterials that can particularly respond to reactive oxygen species (ROS), which are overproduced in the tissue and mitochondria of cancer cells, are still rare for the clinical translation of RNA interference (RNAi)-based therapy. To this end, we developed a ROS-responsive boronic vehicle with a lipid envelope for systemic vascular endothelial growth factor (VEGF) siRNA delivery so as to improve RNAi cancer therapy...
December 6, 2017: Nanoscale
https://www.readbyqxmd.com/read/29209000/deconvoluting-the-photonic-and-electronic-response-of-2d-materials-the-case-of-mos2
#13
Kehao Zhang, Nicholas J Borys, Brian M Bersch, Ganesh R Bhimanapati, Ke Xu, Baoming Wang, Ke Wang, Michael Labella, Teague A Williams, Md Amanul Haque, Edward S Barnard, Susan Fullerton-Shirey, P James Schuck, Joshua A Robinson
Evaluating and tuning the properties of two-dimensional (2D) materials is a major focus of advancing 2D science and technology. While many claim that the photonic properties of a 2D layer provide evidence that the material is "high quality", this may not be true for electronic performance. In this work, we deconvolute the photonic and electronic response of synthetic monolayer molybdenum disulfide. We demonstrate that enhanced photoluminescence can be robustly engineered via the proper choice of substrate, where growth of MoS2 on r-plane sapphire can yield >100x enhancement in PL and carrier lifetime due to increased molybdenum-oxygen bonding compared to that of traditionally grown MoS2 on c-plane sapphire...
December 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29203959/cancer-cell-specific-mitochondrial-reactive-oxygen-species-promote-non-heme-iron-uptake-and-enhance-the-proliferation-of-gastric-epithelial-cancer-cell
#14
Hiromu Ito, Hiromi Kurokawa, Aki Hirayama, Hiroko P Indo, Hideyuki J Majima, Hirofumi Matsui
Iron is an essential nutrient for life and is involved in many important processes such as oxygen transport and DNA synthesis. However, excess amounts of iron can cause carcinogenesis by producing reactive oxygen species. Thus, the cellular transport of iron must be tightly regulated. In the human body, iron may be present as heme or non-heme iron. The mechanisms governing the cellular transport of these forms have not been clearly elucidated. We previously reported that the expression of an important heme transporter, heme carrier protein 1 was regulated by cancer-specific reactive oxygen species derived from mitochondria...
November 2017: Journal of Clinical Biochemistry and Nutrition
https://www.readbyqxmd.com/read/29199757/visible-light-driven-plasmonic-photochemistry-on-nano-textured-silver
#15
Jaspreet Walia, Jean-Michel Guay, Oleksiy Krupin, Fabio Variola, Pierre Berini, Arnaud Weck
Plasmon assisted generation of silver sulfate from dodecanethiol is demonstrated on a nano-textured silver substrate with a strong surface plasmon resonance in the visible range. The observed photo-physical processes are attributed to hot charge carriers that are generated from the excitation of surface plasmon resonances using 532 nm laser light. Excited charge carriers are responsible for cleaving the alkane chain, and for generating reactive oxygen species which rapidly photooxidize the exposed sulfur atoms...
December 4, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29199120/understanding-the-molecular-basis-of-the-high-oxygen-affinity-variant-human-hemoglobin-coimbra
#16
S E Jorge, M Bringas, A A Petruk, M Arrar, M A Marti, M S Skaf, F F Costa, L Capece, M F Sonati, D Estrin
Human hemoglobin (Hb) Coimbra (βAsp99Glu) is one of the seven βAsp99 Hb variants described to date. All βAsp99 substitutions result in increased affinity for O2 and decreased heme-heme cooperativity and their carriers are clinically characterized by erythrocytocis, caused by tissue hypoxia. Since βAsp99 plays an important role in the allosteric α1β2 interface and the mutation in Hb Coimbra only represents the insertion of a CH2 group in this interface, the present study of Hb Coimbra is important for a better understanding of the global impact of small modifications in this allosteric interface...
November 30, 2017: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/29196052/ferulic-acid-loaded-nanostructured-lipid-carriers-a-promising-nanoformulation-against-the-ischemic-neural-injuries
#17
Parichehr Hassanzadeh, Elham Arbabi, Fatemeh Atyabi, Rassoul Dinarvand
AIMS: Treatment of the ischemic stroke has remained a major healthcare challenge. The phenolic compound, ferulic acid (FA), has shown promising antioxidant and neuroprotective effects, however, low bioavailability may negatively affect its efficiency. This, prompted us to incorporate FA into the nanostructured lipid carriers (FA-NLCs) and evaluate its therapeutic potential in in vitro and in vivo models of ischemic stroke. MAIN METHODS: FA-NLCs were prepared by high-pressure homogenization followed by physicochemical characterization, evaluation of the bioactivity of FA-NLCs in oxygen-glucose deprivation (OGD) and global cerebral ischemia/reperfusion (I/R) injury and implication of phosphatidylinositol 3-kinase (PI3K) pathway in this regard...
November 28, 2017: Life Sciences
https://www.readbyqxmd.com/read/29193954/improvement-of-transparent-conducting-performance-on-oxygen-activated-fluorine-doped-tin-oxide-electrodes-formed-by-horizontal-ultrasonic-spray-pyrolysis-deposition
#18
Bon-Ryul Koo, Dong-Hyeun Oh, Doh-Hyung Riu, Hyo-Jin Ahn
In this study, highly transparent conducting fluorine-doped tin oxide (FTO) electrodes were fabricated using the horizontal ultrasonic spray pyrolysis deposition. In order to improve their transparent conducting performances, we carried out oxygen activation by adjusting the ratio of O2/(O2+N2) in the carrier gas (0%, 20%, and 50%) used during the deposition process. The oxygen activation on the FTO electrodes accelerated the substitution concentration of F (FO·) into the oxygen sites in the FTO electrode while the oxygen vacancy (VO··) concentration was reduced...
December 1, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29191902/numerical-evidence-of-fluctuating-stripes-in-the-normal-state-of-high-tc-cuprate-superconductors
#19
Edwin W Huang, Christian B Mendl, Shenxiu Liu, Steve Johnston, Hong-Chen Jiang, Brian Moritz, Thomas P Devereaux
Upon doping, Mott insulators often exhibit symmetry breaking where charge carriers and their spins organize into patterns known as stripes. For high-transition temperature cuprate superconductors, stripes are widely suspected to exist in a fluctuating form. We used numerically exact determinant quantum Monte Carlo calculations to demonstrate dynamical stripe correlations in the three-band Hubbard model, which represents the local electronic structure of the copper-oxygen plane. Our results, which are robust to varying parameters, cluster size, and boundary conditions, support the interpretation of experimental observations such as the hourglass magnetic dispersion and the Yamada plot of incommensurability versus doping in terms of the physics of fluctuating stripes...
December 1, 2017: Science
https://www.readbyqxmd.com/read/29191512/a-unique-respiratory-adaptation-in-drosophila-independent-of-supercomplex-formation
#20
Satoru Shimada, Marika Oosaki, Ryoko Takahashi, Shigefumi Uene, Sachiko Yanagisawa, Tomitake Tsukihara, Kyoko Shinzawa-Itoh
Large assemblies of respiratory chain complexes, known as supercomplexes, are present in the mitochondrial membrane in mammals and yeast, as well as in some bacterial membranes. The formation of supercomplexes is thought to contribute to efficient electron transfer, stabilization of each enzyme complex, and inhibition of reactive oxygen species (ROS) generation. In this study, mitochondria from various organisms were solubilized with digitonin, and then the solubilized complexes were separated by blue native PAGE (BN-PAGE)...
November 27, 2017: Biochimica et Biophysica Acta
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