keyword
https://read.qxmd.com/read/38522574/the-relationship-between-discharge-location-and-cardiac-rehabilitation-use-after-cardiac-surgery
#1
JOURNAL ARTICLE
Tyler M Bauer, Maximilian Fliegner, Hechaun Hou, Temilolaoluwa Daramola, Jeffrey S McCullough, Whitney Fu, Francis D Pagani, Donald S Likosky, Steven J Keteyian, Michael P Thompson
BACKGROUND: Cardiac rehabilitation (CR) is a guideline-recommended risk reduction program offered to cardiac surgical patients. Despite CR's association with better outcomes, attendance remains poor. The relationship between discharge location and CR use is poorly understood. METHODS: This study was a nationwide, retrospective cohort analysis of Medicare fee-for-service claims for beneficiaries undergoing coronary artery bypass grafting and/or surgical aortic valve repair between 07/01/2016 and 12/31/2018...
March 22, 2024: Journal of Thoracic and Cardiovascular Surgery
https://read.qxmd.com/read/38508486/ex-vivo-lung-perfusion-in-donation-after-circulatory-death-a-post-hoc-analysis-of-the-novel-trial
#2
JOURNAL ARTICLE
Doug A Gouchoe, Pablo G Sanchez, Jonathan D'Cunha, Christian A Bermudez, Mani A Daneshmand, Robert D Davis, Matthew G Hartwig, Thomas C Wozniak, Zachary N Kon, Bartley P Griffith, William R Lynch, Tiago N Machuca, Michael J Weyant, Michael E Jessen, Michael S Mulligan, Frank D'Ovidio, Phillip C Camp, Edward Cantu, Bryan A Whitson
OBJECTIVE: Donation after circulatory death (DCD) donors offer the ability to expand the lung donor pool and ex vivo lung perfusion (EVLP) further contributes to this ability by allowing for additional evaluation and resuscitation of these extended criteria donors. We sought to determine the outcomes of recipients receiving organs from DCD EVLP donors in a multi-center setting. METHODS: This was an unplanned post-hoc analysis of a multicenter, prospective, non-randomized trial that took place in 2011-2017 with 3-years of follow up...
March 18, 2024: Journal of Thoracic and Cardiovascular Surgery
https://read.qxmd.com/read/38483109/normothermic-machine-perfusion-for-liver-transplantation-current-state-and-future-directions
#3
JOURNAL ARTICLE
Jessica Lindemann, Jennifer Yu, Mb Majella Doyle
PURPOSE OF REVIEW: The number of patients on the liver transplant waitlist continues to grow and far exceeds the number of livers available for transplantation. Normothermic machine perfusion (NMP) allows for ex-vivo perfusion under physiologic conditions with the potential to significantly increase organ yield and expand the donor pool. RECENT FINDINGS: Several studies have found increased utilization of donation after cardiac death and extended criteria brain-dead donor livers with implementation of NMP, largely due to the ability to perform viability testing during machine perfusion...
March 15, 2024: Current Opinion in Organ Transplantation
https://read.qxmd.com/read/38474010/late-onset-of-primary-hemophagocytic-lymphohistiocytosis-hlh-with-a-novel-constellation-of-compound-heterozygosity-involving-two-missense-variants-in-the-prf1-gene
#4
Alina Stadermann, Markus Haar, Armin Riecke, Thomas Mayer, Christian Neumann, Arthur Bauer, Ansgar Schulz, Kumar Nagarathinam, Niklas Gebauer, Svea Böhm, Miriam Groß, Michael Grunert, Matthias Müller, Hanno Witte
Hemophagocytic lymphohistiocytosis (HLH) is a rare but in most cases life-threatening immune-mediated disease of the hematopoietic system frequently associated with hematologic neoplasms. Here, we report on a case in which we detected a novel constellation of two missense variants affecting the PRF1 gene, leading to de novo primary HLH. Diagnostics included a comprehensive clinical work-up and standard methods of hematopathology as well as extended molecular genomics based on polymerase chain reaction (PCR) reactions and the calculation of three-dimensional molecule reconstructions of PRF1 ...
February 27, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38463874/mitochondrial-dna-levels-in-perfusate-and-bile-during-ex-vivo-normothermic-machine-correspond-with-donor-liver-quality
#5
JOURNAL ARTICLE
Lauren P Westhaver, Sarah Nersesian, Riley J Arseneau, Joshua Hefler, Breanna K V Hargreaves, Alexander Edgar, Yara Azizieh, Nerea Cuesta-Gomez, Dayne L Izquierdo, A M James Shapiro, Boris L Gala-Lopez, Jeanette E Boudreau
Ex vivo normothermic machine perfusion (NMP) preserves donor organs and permits real-time assessment of allograft health, but the most effective indicators of graft viability are uncertain. Mitochondrial DNA (mtDNA), released consequent to traumatic cell injury and death, including the ischemia-reperfusion injury inherent in transplantation, may meet the need for a biomarker in this context. We describe a real time PCR-based approach to assess cell-free mtDNA during NMP as a universal biomarker of allograft quality...
March 15, 2024: Heliyon
https://read.qxmd.com/read/38455485/using-extracorporeal-membrane-oxygenation-in-donations-after-cardiac-death-or-brain-death-a-single-center-experience-and-long-term-outcome
#6
JOURNAL ARTICLE
Chia-En Hsieh, Ya-Lan Hsu, Yao-Li Chen, Hsin-Rou Liang, Kuo-Hua Lin, Wen-Yuan Chen, Hsiu-Man Wu, Sin-Bao Hunang, Yu-Ju Hung
AIMS: The use of extended criteria donors is a routine practice that sometimes involves extracorporeal membrane oxygenation (ECMO) in donations after cardiac death or brain death. METHODS: We performed a retrospective study in a single center from January 2006 to December 2019. The study included 90 deceased donor liver transplants. The patients were divided into three groups: the donation after brain death (DBD) group ( n  = 58, 64.4%), the DBD with ECMO group ( n  = 11, 12...
March 2024: Annals of Gastroenterological Surgery
https://read.qxmd.com/read/38446386/kidney-transplants-from-elderly-donors-what-we-have-learned-20%C3%A2-years-after-the-crystal-city-consensus-criteria-meeting
#7
REVIEW
Alberto Mella, Ruggero Calvetti, Antonella Barreca, Giovanni Congiu, Luigi Biancone
Based on the current projection of the general population and the combined increase in end-stage kidney disease with age, the number of elderly donors and recipients is increasing, raising crucial questions about how to minimize the discard rate of organs from elderly donors and improve graft and patient outcomes. In 2002, extended criteria donors were the focus of a meeting in Crystal City (VA, USA), with a goal of maximizing the use of organs from deceased donors. Since then, extended criteria donors have progressively contributed to a large number of transplanted grafts worldwide, posing specific issues for allocation systems, recipient management, and therapeutic approaches...
March 6, 2024: Journal of Nephrology
https://read.qxmd.com/read/38439563/outcomes-after-lung-transplantation-from-selected-donors-older-than-70-years-in-a-single-center-time-to-close-the-debate
#8
JOURNAL ARTICLE
Alejandra Romero Román, Mariana Gil Barturen, Silvana Crowley Carrasco, Lucas Hoyos Mejía, Jose Manuel Naranjo Gómez, Mar Córdoba Peláez, Marina Pérez Redondo, Ana Royuela Vicente, Christian García Fadul, David Gómez De Antonio, Nuria María Novoa, Jose Luis Campo-Cañaveral De La Cruz
OBJECTIVES: To compare the outcomes of lung transplantations using grafts from donors aged over 70 years against those performed using younger donors. MATERIAL AND METHODS: This retrospective single-center analysis includes lung transplants conducted at our institution from January 2014 to June 2022. Lung recipients were classified into two groups based on donor age (Group A < 70 yo; group B ≥ 70 yo). Variables regarding demographics, peri, and postoperative outcomes, and survival were included...
March 4, 2024: European Journal of Cardio-thoracic Surgery
https://read.qxmd.com/read/38375953/de-novo-hepatitis-b-infection-following-liver-transplantation-with-core-antibody-positive-grafts-the-role-of-surface-antibody-status-in-guiding-long-term-prophylaxis
#9
JOURNAL ARTICLE
Brad Busebee, Laura Myhre, Kristin Mara, Bashar Aqel, Timucin Taner, Kymberly D Watt
Liver transplantation (LT) with hepatitis B core antibody (anti-HBc) positive grafts to hepatitis B surface-antigen (HBsAg) negative recipients is safe and has likely contributed to improvements in organ access over the years. The incidence of de novo hepatitis B infection (HBV) in these instances is low with appropriate prophylaxis and is affected by recipient immunologic status. There is debate as to whether hepatitis B surface antibody (anti-HBs) positivity may safely inform prophylaxis discontinuation post-LT...
February 2024: Clinical Transplantation
https://read.qxmd.com/read/38365509/optimising-oral-cancer-reconstruction-a-retrospective-cohort-study-on-the-modified-radial-forearm-free-flap-technique-to-eliminate-the-need-for-a-secondary-donor-site
#10
JOURNAL ARTICLE
Weijia Huang, Victoria Chen, Zefeng Xie, Azadeh Rezaei, Yanming Liu
The radial forearm free flap (RFFF) is commonly used in the reconstruction of oral cancer patients. Traditional RFFF (TRFFF) techniques, which often require a secondary donor site to repair the forearm defect, may result in a scar extending to the dorsal hand. This can lead to significant functional and aesthetic concerns in the forearm. We designed a modified RFFF (MRFFF) that incorporates a glasses-shaped flap and features deep venous drainage. To evaluate its effectiveness we conducted a retrospective chart review of 105 patients with oral squamous cell carcinoma who underwent reconstructive surgery between 2018 and 2022...
December 12, 2023: British Journal of Oral & Maxillofacial Surgery
https://read.qxmd.com/read/38361685/the-potential-role-of-nod2-card15-genotype-as-a-prognostic-indicator-for-bone-marrow-transplantation-outcomes-in-patients-with-acute-lymphoblastic-leukemia-and-acute-myeloid-leukemia-a-systematic-review
#11
REVIEW
Leila Ahmadinia, Shahid B Rangrej, Maria Miranda, Christine Shailer, Waleed Ahmed, Victoria Carvalho, Rajni Rathore
Hematopoietic stem-cell transplantation (HSCT) has emerged as a groundbreaking therapeutic option for acute myeloid leukemia (AML) and specific subtypes of acute lymphoblastic leukemia (ALL). The prognostic significance of the NOD2/CARD15 gene has been explored alongside various factors, encompassing diverse patient cohorts and gene variants. Siblings and unrelated donors used for stem cell transplantation exhibit significant associations between their genetic variations and graft-versus-host disease incidence...
January 2024: Curēus
https://read.qxmd.com/read/38352660/post-transplant-diabetes-mellitus-risk-factors-and-outcomes-in-a-5-year-follow-up
#12
JOURNAL ARTICLE
Matheus Rizzato Rossi, Marilda Mazzali, Marcos Vinicius de Sousa
INTRODUCTION: Kidney transplantation is associated with an increased risk of posttransplant diabetes mellitus (PTDM), impacting recipient and graft survivals. The incidence of PTDM ranges from 15% to 30%, with most cases occurring in the first year post-transplant. Some clinical and laboratory characteristics pre- and post-transplant may be associated with a higher PTDM incidence in a more extended follow-up period. This study aimed to analyze the prevalence of PTDM among renal transplant recipients without previous DM diagnosis during a five-year post-transplant follow-up, as well as clinical and laboratory characteristics associated with a higher incidence of PTDM during this period...
2024: Front Clin Diabetes Healthc
https://read.qxmd.com/read/38339128/modification-of-preservative-fluids-with-antioxidants-in-terms-of-their-efficacy-in-liver-protection-before-transplantation
#13
REVIEW
Aneta Ostróżka-Cieślik
Transplantation is currently the only effective treatment for patients with end-stage liver failure. In recent years, many advanced studies have been conducted to improve the efficiency of organ preservation techniques. Modifying the composition of the preservation fluids currently used may improve graft function and increase the likelihood of transplantation success. The modified fluid is expected to extend the period of safe liver storage in the peri-transplantation period and to increase the pool of organs for transplantation with livers from marginal donors...
February 3, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38315126/improved-outcomes-after-hypothermic-oxygenated-machine-perfusion-in-liver-transplantation-long-term-follow-up-of-a-multicenter-randomized-controlled-trial
#14
RANDOMIZED CONTROLLED TRIAL
Zoltan Czigany, Deniz Uluk, Sandra Pavicevic, Isabella Lurje, Jiří Froněk, Theresa Keller, Pavel Strnad, Decan Jiang, Tom Gevers, Dionysios Koliogiannis, Markus Guba, Rene H Tolba, Franziska A Meister, Ulf P Neumann, Matej Kocik, Marek Kysela, Igor M Sauer, Nathanael Raschzok, Wenzel Schöning, Irinel Popescu, Frank Tacke, Johann Pratschke, Georg Lurje
BACKGROUND: While 4 randomized controlled clinical trials confirmed the early benefits of hypothermic oxygenated machine perfusion (HOPE), high-level evidence regarding long-term clinical outcomes is lacking. The aim of this follow-up study from the HOPE-ECD-DBD trial was to compare long-term outcomes in patients who underwent liver transplantation using extended criteria donor allografts from donation after brain death (ECD-DBD), randomized to either HOPE or static cold storage (SCS)...
February 1, 2024: Hepatology Communications
https://read.qxmd.com/read/38276933/increasing-utilization-of-extended-criteria-donor-hearts-for-transplantation-the-ocs-heart-expand-trial
#15
MULTICENTER STUDY
Jacob N Schroder, Chetan B Patel, Adam D DeVore, Sarah Casalinova, Kevin J Koomalsingh, Ashish S Shah, Anelechi C Anyanwu, David A D'Alessandro, Karol Mudy, Benjamin Sun, Martin Strueber, Asghar Khaghani, Yasuhiro Shudo, Fardad Esmailian, Kenneth Liao, Francis D Pagani, Scott Silvestry, I-Wen Wang, Christopher T Salerno, Tarek S Absi, Joren C Madsen, Donna Mancini, Amy G Fiedler, Carmelo A Milano, Jason W Smith
BACKGROUND: Extended criteria donor (ECD) hearts available with donation after brain death (DBD) are underutilized for transplantation due to limitations of cold storage. OBJECTIVES: This study evaluated use of an extracorporeal perfusion system on donor heart utilization and post-transplant outcomes in ECD DBD hearts. METHODS: In this prospective, single-arm, multicenter study, adult heart transplant recipients received ECD hearts using an extracorporeal perfusion system if hearts met study criteria...
March 2024: JACC. Heart Failure
https://read.qxmd.com/read/38256190/focusing-on-ischemic-reperfusion-injury-in-the-new-era-of-dynamic-machine-perfusion-in-liver-transplantation
#16
REVIEW
Gabriela Chullo, Arnau Panisello-Rosello, Noel Marquez, Jordi Colmenero, Merce Brunet, Miguel Pera, Joan Rosello-Catafau, Ramon Bataller, Juan Carlos García-Valdecasas, Yiliam Fundora
Liver transplantation is the most effective treatment for end-stage liver disease. Transplant indications have been progressively increasing, with a huge discrepancy between the supply and demand of optimal organs. In this context, the use of extended criteria donor grafts has gained importance, even though these grafts are more susceptible to ischemic reperfusion injury (IRI). Hepatic IRI is an inherent and inevitable consequence of all liver transplants; it involves ischemia-mediated cellular damage exacerbated upon reperfusion and its severity directly affects graft function and post-transplant complications...
January 17, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38250465/l-graft-7-has-high-accuracy-in-predicting-early-allograft-failure-after-liver-transplantation-a-multicenter-cohort-study-in-china
#17
JOURNAL ARTICLE
Songming Li, Qijie Luo, Shirui Chen, Zehua Jia, Tielong Wang, Xinyu Yu, Wenjing Wang, YuyiZhang, Jiaxing Zhu, Feiwen Deng, Qiang Sun, Zhiyong Guo, Xiaoshun He
BACKGROUND AND AIMS: Increasing utilization of extended criteria donor leads to an increasing rate of early allograft failure after liver transplantation. However, consensus of definition of early allograft failure is lacking. METHODS: A retrospective, multicenter study was performed to validate the Liver Graft Assessment Following Transplantation (L-GrAFT) risk model in a Chinese cohort of 942 adult patients undergoing primary liver transplantation at three Chinese centers...
January 28, 2024: Journal of Clinical and Translational Hepatology
https://read.qxmd.com/read/38231231/use-of-a-donor-kidney-with-known-autosomal-dominant-polycystic-kidney-disease-in-a-highly-sensitised-paediatric-recipient
#18
JOURNAL ARTICLE
Theresa Peltz, Vlad Shumeyko, Ben Reynolds
We report the use of an autosomal-dominant polycystic kidney disease (ADPKD) donor kidney in a paediatric recipient. A 14-year-old boy on haemodialysis for 4 years following loss of a first kidney transplant, highly sensitised, and with limited vascular options for ongoing dialysis access, was offered a deceased brain death donor transplant from a mid-30s donor with known ADPKD but normal kidney function and negligible proteinuria. After extensive discussion with the patient and family, discussing all alternative options and review of available literature, the kidney was accepted and implanted...
January 17, 2024: Pediatric Nephrology
https://read.qxmd.com/read/38215675/association-of-racial-and-economic-privilege-on-postoperative-outcomes-among-medicare-beneficiaries
#19
JOURNAL ARTICLE
Muhammad Musaab Munir, Henrique A Lima, Yutaka Endo, Zorays Moazzam, Selamawit Woldesenbet, Lovette Azap, Erryk Katayama, Mary Dilhoff, Jordan Cloyd, Aslam Ejaz, Timothy M Pawlik
INTRODUCTION: Social determinants of health can play an important role in patient health. Privilege is a right, benefit, advantage, or opportunity that can positively affect all social determinants of health. We sought to assess variations in the prevalence of privilege among patient populations and define the association of privilege on postoperative surgical outcomes. METHODS: Medicare beneficiaries who underwent elective coronary artery bypass grafting, abdominal aortic aneurysm repair, total hip arthroplasty, total knee arthroplasty, colectomy, and lung resection were identified...
January 11, 2024: Journal of Surgical Research
https://read.qxmd.com/read/38199859/important-constituents-of-heavy-water-containing-solution-for-cold-storage-and-subsequent-reperfusion-on-an-isolated-perfused-rat-liver
#20
JOURNAL ARTICLE
Moto Fukai, Sodai Sakamoto, Kengo Shibata, Takahisa Ishikawa, Norio Kawamura, Masato Fujiyoshi, Sunao Fujiyoshi, Kosei Nakamura, Hiroki Bochimoto, Shingo Shimada, Tsuyoshi Shimamura, Akinobu Taketomi
The University of Wisconsin (UW) solution is the most effective preservation solution currently used; however, to safely use expanded-criteria donor grafts, a new cold storage solution that alleviates graft injury more effectively is required. We prepared a heavy water (D2 O)-containing buffer, Dsol, and observed strong protective effects during extended cold storage of rat hearts and livers. In the current study, we modified Dsol (mDsol) and tested its efficacy. The aim of the present study was to determine whether mDsol could protect the rat liver more effectively than the UW solution and to clarify the roles of D2 O and deferoxamine (DFX)...
January 9, 2024: Transplantation Proceedings
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