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https://www.readbyqxmd.com/read/29129237/iron-induced-pro-oxidant-and-pro-lipogenic-responses-in-relation-to-impaired-synthesis-and-accretion-of-long-chain-polyunsaturated-fatty-acids-in-rat-hepatic-and-extrahepatic-tissues
#1
Rodrigo Valenzuela, Miguel Ángel Rincón-Cervera, Francisca Echeverría, Cynthia Barrera, Alejandra Espinosa, María Catalina Hernández-Rodas, Macarena Ortiz, Alfonso Valenzuela, Luis A Videla
OBJECTIVES: Iron is involved in processes involving oxygen transfer and utilization. Excess iron is linked to cardiovascular diseases and some types of cancer. Iron overload is associated with oxidative stress development, and may have important interactions with lipid metabolism in the liver favoring the development and progression of non-alcoholic fatty liver disease. The aim of the study described here was to assess the effect of high intake of iron on oxidative stress-related parameters, lipid metabolism, and levels of long-chain polyunsaturated fatty acids (LCPUFAs) in liver and other tissues of the rat...
January 2018: Nutrition
https://www.readbyqxmd.com/read/29119034/a-unique-case-of-testicular-compromise-in-a-patient-with-ovotesticular-disorder-of-sexual-development-and-a-solitary-testicle
#2
Ethan Vargo, Lillianne Stanitsas, Mark Memo
Ovotesticular disorder of sexual development (OT-DSD), previously true hermaphroditism, is a condition in which one or both gonads contain testicular and ovarian tissue. A 23-year-old OT-DSD male patient presented with continuous pain in his right testicle which had been previously intermittent over the past five days. The patient had a prior history of left ovotestis removal with prosthesis placement, a right undescended testicle with aberrant anatomy, and hypospadias repair, all of which were corrected shortly after birth...
2017: Case Reports in Urology
https://www.readbyqxmd.com/read/29108039/effect-of-band-and-knife-castration-of-beef-calves-on-welfare-indicators-of-pain-at-three-relevant-industry-ages-ii-chronic-pain
#3
S Marti, D M Meléndez, E A Pajor, D Moya, C E M Heuston, D Gellatly, E D Janzen, K S Schwartzkopf-Genswein
Three experiments were conducted to evaluate the effects of band and knife castration on behavioral and physiological indicators of chronic pain in beef calves at 3 different ages (36 calves/age group): 1 wk of age (Exp. 1, 4 ± 1.1 d of age, 43 ± 1.1 kg BW), 2 mo of age (Exp. 2, 63 ± 2.3 d of age, 92 ± 1.7 kg BW), and 4 mo of age (Exp. 3, 125 ± 4.6 d of age, 160 ± 3.4 kg BW). In each experiment calves were randomly assigned to either sham (CT), band (BA) or knife (KN) castration. Experiments 1, 2, and 3 ended when the testicles of banded calves had sloughed off (68, 49, and 42 d, respectively)...
October 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/29098788/urine-reference-intervals-for-human-chorionic-gonadotropin-hcg-isoforms-by-immunoextraction-tandem-mass-spectrometry-to-detect-hcg-use
#4
Anthony W Butch, Brian D Ahrens, Nuraly K Avliyakulov
Human chorionic gonadotropin (hCG) stimulates testosterone production by the testicles and can normalize suppressed testosterone concentrations in males following prolonged anabolic steroid use. Because of the potential for abuse by males, hCG is on the World Anti-Doping Agency (WADA) list of prohibited substances. The majority of WADA-accredited laboratories measure urinary hCG using an automated immunoassay. Only immunoassays that recognize the intact alpha and beta heterodimer of hCG (intact hCG) should be used to measure urinary hCG for doping control purposes since intact hCG is the only biologically active molecule...
November 3, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/29091121/choledocystus-elegans-digenea-plagiorchiidae-of-leptodactylus-paraensis-amphibia-leptodactylidae-from-the-brazilian-amazon
#5
Tássia Fernanda Furo Gomes, Francisco Tiago de Vasconcelos Melo, Elane Guerreiro Giese, Adriano Penha Furtado, Jeannie Nascimento Dos Santos
The trematodes are parasites of the several vertebrates including amphibians, however the knowledge about of the taxonomy these parasites is still confuse. The trematode Choledocystus elegans was found in the small intestine of the Leptodactylus paraensis in eastern Amazon and presents the following characteristics: several pointed tegumentary spines, papillae on the outer and inner edges of the oral and ventral suckers, a round, well-developed cirrus sac, a well-developed cirrus, oblique testicles, a ovary right side, uterine loops extending between the testicles, follicular vitellaria distributed throughout the body, starting at the genital pore region and caeca close the end of the body...
October 30, 2017: Revista Brasileira de Parasitologia Veterinária, Brazilian Journal of Veterinary Parasitology
https://www.readbyqxmd.com/read/29090218/testicular-damage-following-testicular-sperm-retrieval-a-ram-model-study
#6
Jens Fedder, Niels Marcussen, Maja D K Fedder, Birte Engvad
The aim of this study was to evaluate the possible development of histological abnormalities such as fibrosis and microcalcifications after sperm retrieval in a ram model. Fourteen testicles in nine rams were exposed to open biopsy, multiple TESAs, or TESE, and the remaining four testicles were left unoperated on as controls. Three months after sperm retrieval, the testicles were removed, fixed, and cut into 1/2 cm thick slices and systematically put onto a glass plate exposing macroscopic abnormalities. Tissue from abnormal areas was cut into 3 μm sections and stained for histological evaluation...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29082702/-effects-of-mori-folium-extract-on-diet-induced-obesity-mechanism-in-rats
#7
Wen Wu, Kai-Lun Liang, Bo Chen, Jie Su, Su-Hong Chen, Gui-Yuan Lyu
To study the anti-obesity effect of Mori Folium extract on diet-induced obesity(DIO) and to explore the preliminary mechanism in rats. DIO rat models were established by high glucose and high fat diet for 8 weeks. Then high(10 mg•kg⁻¹) and low(5 mg•kg⁻¹) does Mori Folium extracts were given by intragastric administration for 13 weeks. After the last administration, their body weight, 24 h food intake, water intake, Lee's index, liver/body mass index, and fat/body mass index were determined. The levels of lipoprotein lipase(LPL), CCAAT/enhancer-binding protein alpha(C/EBPα) and peroxisome proliferator-activated receptor gamma(PPARγ) were measured by enzyme-linked immunosorbent assay(ELISA)...
May 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29069489/effects-of-intraperitoneal-injection-of-sns2-flowers-on-mouse-testicle
#8
Disi Bai, Qingzhao Li, Yanjie Xiong, Junjian Zhao, Liyuan Bai, Peijun Shen, Lu Yuan, Ping Wu
SnS 2 nanoflowers (SnS 2 NFs) have been widely used in photoelectric and catalytic applications. However, its explosure and reproductive toxicity is unknown. The aim of this study was to investigate the effect of exposure to three different sized-SnS 2 flowers (dose: 38 mg/Kg; size: 50, 80 and 200 nm) in testes of mice for 4 weeks by intraperitoneal injection. Though the body weight of mice treated or not with SnS 2 NFs was not different, and SnS 2 NFs were distributed to the organs including liver, kidney, spleen, heart, brain and testis, more distribution SnS 2 NFs (50 and 80 nm) were found in testicle tissues compared with SnS 2 flowers (200 nm) in those tissues...
October 23, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29057491/insight-into-curcumin-nanomicelle-induced-derangements-in-male-reproduction-potential-an-experimental-study
#9
S Moshari, V Nejati, G Najafi, M Razi
This study was conducted to investigate the possible effects of nanomicelle curcumin (NMC) on spermatogenesis, sperm parameters and in vitro fertilisation potential. For this purpose, 24 mature male Wistar rats were divided into control and test groups. The animals in test groups received 7.5, 15 and 30 mg kg b.w(-1) of NMC (NO = 6 rats in each group). Following 48 days, the DNA integrity of testicular tissues, tubular differentiation (TDI) and spermiogenesis (SPI) indices, sperm parameters and DNA integrity were analysed...
October 23, 2017: Andrologia
https://www.readbyqxmd.com/read/29040905/bilateral-methachronous-testicular-germ-cell-tumor-and-testicular-microlithiasis-in-a-child-genetic-analysis-and-insights-a-case-report
#10
N Boudaoud, G Loron, M Pons, E Landais, S Kozal, M Doco-Fenzy, M L Poli-Merol
OBJECTIVES: To report our experience with a case of a child with bilateral testicular micro-lithiasis (TML) who developed bilateral metachronous testicular germ cell tumor (TGCT) and determine the most appropriate follow-up and care management in children with testicular micro calcifications in regards to the theoretical risk of testicular cancer. CASE REPORT: A 12 year-old boy was diagnosed with TGCT and TML. Ten years after complete remission, he presented with a recurrence on the contralateral testis...
October 14, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29031171/transverse-testicular-ectopia-with-inguinal-hernia-a-rare-case-report
#11
Shubhi Bhatnagar, Shahaji Chavan, Mahendra Bendre
INTRODUCTION: Transverse aberrant testicular maldescent is an extremely rare congenital anomaly characterized by the migration of one testicle towards the opposite inguinal canal. Mostly such cases are reported in children and they are very rarely seen in adults. PRESENTATION OF CASE: We report a case of a 24year old male patient with left reducible indirect inguinal hernia with absence of testis in the right hemiscrotum.On surgical exploration, the patient had both the testicles on the left side...
October 6, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29029632/fatal-haemorrhage-and-neoplastic-thrombosis-in-a-captive-african-lion-panthera-leo-with-metastatic-testicular-sex-cord-stromal-tumour
#12
Omar Antonio Gonzales-Viera, Angélica María Sánchez-Sarmiento, Natália Coelho Couto de Azevedo Fernandes, Juliana Mariotti Guerra, Rodrigo Albergaria Ressio, José Luiz Catão-Dias
BACKGROUND: The study of neoplasia in wildlife species contributes to the understanding of cancer biology, management practices, and comparative pathology. Higher frequencies of neoplasms among captive non-domestic felids have been reported most commonly in aging individuals. However, testicular tumours have rarely been reported. This report describes a metastatic testicular sex cord-stromal tumour leading to fatal haemorrhage and thrombosis in a captive African lion (Panthera leo). CASE PRESENTATION: During necropsy of a 16-year-old male African lion, the left testicle and spermatic cord were found to be intra-abdominal (cryptorchid), semi-hard and grossly enlarged with multiple pale-yellow masses...
October 13, 2017: Acta Veterinaria Scandinavica
https://www.readbyqxmd.com/read/28991134/isolated-testicular-recurrence-of-aml-in-patients-with-chronic-gvhd-1-year-following-allogeneic-stem-cell-transplant
#13
Brian N Dang, Satiro De Oliveira, LaVette Bowles, Theodore B Moore
BACKGROUND: Patients with chronic graft-versus-host disease (cGVHD) following allogeneic transplant for myeloid leukemias seem to experience a reduced risk of relapse than comparable patients without cGVHD. It is unclear to what extent extramedullary sites are impacted by a graft-versus-leukemia effect. DESIGN/METHOD: Case Series and review of the literature. RESULTS: We present 2 cases of pediatric patients with Acute Myelogenous Leukemia who developed isolated testicular relapse more than a year following hematopoietic stem cell transplantation despite having had extensive cGVHD...
November 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/28959743/new-promising-strategies-in-oncofertility
#14
Janella N Hudson, Nathanael B Stanley, Leena Nahata, Meghan Bowman-Curci, Gwendolyn P Quinn
INTRODUCTION: Approximately 70,000 adolescent and young adults (AYA) are diagnosed with cancer each year. While advancements in treatment have led to improved prognosis and survival for patients, these same treatments can adversely affect AYA reproductive capacity. Localized treatments such as surgery and radiation therapy may affect fertility by removing or damaging reproductive organs, and systemic therapies such as chemotherapy can be toxic to gonads, (ovaries and testicles), thus affecting fertility and/or endocrine function...
2017: Expert Review of Quality of Life in Cancer Care
https://www.readbyqxmd.com/read/28955441/the-great-impostor-lues-maligna-in-an-hiv-infected-male
#15
Alfredo J Mena Lora, Marylee Braniecki, Ayman Nasir, Maximo Brito
Lues maligna is a rare severe cutaneous manifestation of secondary syphilis. It is also known as malignant syphilis and ulceronodular syphilis. We report a case of a 58-year-old HIV-infected male who presented with diffuse, pruritic, non-tender, maculo-papular skin lesions, ulcerated nodules and plaques surrounded by an erythematous base. The disseminated skin lesions were at various stages and were located on his back, chest, arms and testicles. Patient had been receiving antiretroviral therapy. Laboratory studies had demonstrated CD4 lymphocyte count of 463 cells/mm(3) and an undetectable HIV viral load...
2017: SAGE open medical case reports
https://www.readbyqxmd.com/read/28953100/a-systematic-review-of-testicle-survival-time-after-a-torsion-event
#16
Larry Bruce Mellick, James E Sinex, Robert W Gibson, Kim Mears
BACKGROUND: The time window for possible salvage and survival of a torsed testicle is commonly thought to be 6 to 8 hours. However, survival of torsed testicles with or without subsequent atrophy is known to occur outside that critical time window. In this article, we performed a systematic review of the English literature to provide a more accurate understanding of reported time frames of testicle survival after a torsion event. OBJECTIVES: The primary research question was to determine the relationship between time to treatment and the rate of survival for testicles of male patients presenting with testicular torsion (TT)...
September 25, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/28951358/-effect-of-di-2-ethylhcxyl-phthalate-exposure-on-blood-testis-barrier-integrity-in-rats
#17
Lian-Ju Shen, Xiang-Liang Tang, Chun-Lan Long, Xi-Ning Cao, Yi Wei, Yang-Cai Wang, Mang Sun, Yue Zhou, Yang Liu, Bo Liu, Fang-Yuan Huang, Guang-Hui Wei
OBJECTIVE: To investigate mechanism of di-(2-ethylhcxyl)phthalate (DEHP) exposure in causing blood-testis barrier (BTB) impairment in rats. METHODS: Two-months-old male SD rats were randomly divided into corn oil control group and DEHP (750 mg/kg) exposure group for daily intragastic treatment for 30 consecutive days. After the treatments the rats were examined for histomorphological changes of the testicle using HE staining and the expressions of the junction proteins N-cadherin β-catenin, occludin and connexin43 of the BTB using Western blot...
September 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/28932692/patient-with-antiphospholipid-syndrome-presenting-with-testicular-torsion-like-symptoms
#18
Arnav Srivastava, Joan Ko, Joy Ogunsile, Alison Moliterno, William H Westra, Alice Semerjian
Testicular torsion, a urological emergency, occurs due to absence of testicular blood supply secondary to a mechanical twist of the spermatic cord. The authors describe a 28-year-old male who presented with torsion symptoms, first in the left testicle and four months later in the right testicle. Doppler ultrasound and surgical exploration revealed disruption of blood flow but no evidence of spermatic cord twisting. Additionally, physical examination findings at the time of presentation were inconsistent with testicular torsion...
November 2017: Urology Case Reports
https://www.readbyqxmd.com/read/28928916/aggressive-angiomyxoma-of-the-perineum-a-rare-presentation-in-a-male-with-4-years-follow-up
#19
Salil Umranikar, Sarvpreet Ubee, Graham Williams
Angiomyxoma are rare myxoid cells tumours that occur predominantly in women in the fourth decade. They are classified as the less aggressive superficial and the deeper aggressive variety commonly called aggressive angimyxomas. We report a rare perineal aggressive angiomyxoma in a 79-year-old male presenting with a painless perineo-scrotal mass. Radiological investigations confirmed a lobulated well-defined mass separate from the testicles and histology following wide local excision confirmed aggressive angiomyxoma...
August 2017: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/28926509/testicular-torsion-pain-honeymoons
#20
Larry Bruce Mellick, James Sinex
A subset of testicular torsion patients report resolution of their initial severe pain that is followed by variable periods of hours to days of reduced or absent pain. Other patients report only mild pain that is described as gradual in onset. Because of delayed initial presentations or less than timely returns for secondary evaluation, these pain honeymoons may be partially responsible for poor clinical outcomes of the torsed spermatic cords and ischemic testicles.
September 18, 2017: Pediatric Emergency Care
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