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https://www.readbyqxmd.com/read/29774668/varicocele-and-testicular-pain-a-review
#1
REVIEW
Sunghyun Paick, Woo Suk Choi
Varicocele is the dilatation of the scrotal portion of pampiniform plexus and the internal spermatic venous system. About 15% of men suffer from scrotal varicocele and 2% to 10% of them complain of pain. The probable mechanisms for pain include compression of the surrounding neural fibers by the dilated venous complex, elevated testicular temperature, increased venous pressure, hypoxia, oxidative stress, hormonal imbalances, and the reflux of toxic metabolites of adrenal or renal origin. Testicular pain associated with varicoceles is typically described as a dull, aching, or throbbing pain in the testicle, scrotum, or groin; rarely, it can be acute, sharp, or stabbing...
May 16, 2018: World Journal of Men's Health
https://www.readbyqxmd.com/read/29773185/kinetics-and-tissue-distribution-of-bismuth-tin-and-lead-after-implantation-of-miniature-shotgun-alloy-pellets-in-rats
#2
Vidar Skaug, Einar Eilertsen, Asbjørn Skogstad, Finn E S Levy, Balázs Berlinger, Yngvar Thomassen, Dag G Ellingsen
INTRODUCTION: Shotgun pellets containing bismuth (Bi) as substitute for lead (Pb) are increasingly being used due to environmental concerns. Information on toxicokinetics of Bi is lacking for the assessment of humans accidentally shot by Bi-containing shotgun alloy pellets. METHODS: Male Wistar rats were exposed to miniature alloy pellets containing Bi, tin (Sn) and minor amounts of Pb by implantation in muscle tissues of the hind legs. RESULTS: The concentrations of Bi in whole blood and urine increased up to 53 weeks after implantation...
July 2018: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/29770282/mature-testicular-teratoma-with-a-focus-of-embryonal-carcinoma-a-case-report-and-review-of-literature
#3
Waliul Chowdhury, Muhammad Uzair Lodhi, Intekhab Askari Syed, Umar Rahim, Mustafa Rahim
We present a 37-year-old male patient with a mature teratoma of the right testicle with a focus of embryonal carcinoma. This patient's tumor metastasized radically to the retroperitoneum, right adrenal gland, bilateral lungs, and liver. A metastatic teratoma with embryonal carcinoma in males is a very rare case. We will describe our patient's case, diagnostic workup, and management in detail, in addition to reviewing the related literature.
March 15, 2018: Curēus
https://www.readbyqxmd.com/read/29765499/effect-of-heat-stress-on-sperm-dna-protamine-assessment-in-ram-spermatozoa-and-testicle
#4
Thais Rose Dos Santos Hamilton, Adriano Felipe Perez Siqueira, Letícia Signori de Castro, Camilla Mota Mendes, Juliana de Carvalho Delgado, Patrícia Monken de Assis, Leonardo Pereira Mesquita, Paulo César Maiorka, Marcílio Nichi, Marcelo Demarchi Goissis, José Antonio Visintin, Mayra Elena Ortiz D Ávila Assumpção
Sperm DNA fragmentation is considered one of the main causes of male infertility. The most accepted causes of sperm DNA damage are deleterious actions of reactive oxygen species (ROS), defects in protamination, and apoptosis. Ram sperm are highly prone to those damages due to the high susceptibility to ROS and to oxidative stress caused by heat stress. We aimed to evaluate the effects of heat stress on the chromatin of ejaculated and epididymal sperm and the activation of apoptotic pathways in different cell types in ram testis...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29757668/a-case-of-parasitic-twinning-or-caudal-duplication-in-a-dog
#5
Janet A Grimes, Adrien-Maxence Hespel, Robert C Cole, A Ray Dillon
A 6 mo old 13.5 kg (29.7 lb) male intact American Staffordshire terrier was evaluated for a history of supernumerary pelvic limbs, with malodorous discharge from a supernumerary penis. Imaging (radiographs, abdominal ultrasound, and computed tomography with excretory urogram) showed a supernumerary pelvis with associated pelvic limbs, no osseous continuity with the primary spinal column, a colonic diverticulum extending to the supernumerary pelvis, an enlarged left kidney with a ureter connecting to a single bladder, right renal aplasia, a single descended testicle in the primary scrotum, an intra-abdominal cryptorchid testicle, and two unidentifiable soft tissue masses...
May 14, 2018: Journal of the American Animal Hospital Association
https://www.readbyqxmd.com/read/29745090/are-ultrasonographic-measurements-a-reliable-parameter-to-choose-non-palpable-testicular-masses-amenable-to-treatment-with-sparing-surgery
#6
Lucio Dell'Atti, Paola Fulvi, Andrea Benedetto Galosi
PURPOSE: To analyze the dimensional characteristics between non-palpable testicular masses detected during ultrasonographic (US) study and their postoperative dimensions reported in definitive histological diagnosis, and evaluate if the sonographic measurements may be a relevant parameter to improve the identification of testicular lesions amenable to treatment with testicular-sparing surgery (TSS). METHODS: A total of 77 patients who underwent radical orchiectomy or TSS for non-palpable testicular masses suspected for malignant neoplasms were included into this study...
March 2018: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29730308/in-vitro-and-in-silico-studies-reveal-capsid-mutant-porcine-circovirus-2b-with-novel-cytopathogenic-and-structural-characteristics
#7
Taís Fukuta Cruz, Angelo José Magro, Alessandra M M G de Castro, Francisco J Pedraza-Ordoñez, Miriam Harumi Tsunemi, David Perahia, João Pessoa Araújo
Porcine circovirus 2 (PCV2) is an icosahedral, non-enveloped, and single-stranded circular DNA virus that belongs to the family Circoviridae, genus Circovirus, and is responsible for a complex of different diseases defined as porcine circovirus diseases (PCVDs). These diseases - including postweaning multisystemic wasting syndrome (PMWS), enteric disease, respiratory disease, porcine dermatitis and nephropathy syndrome (PDNS), and reproductive failure - are responsible for large economic losses in the pig industry...
May 3, 2018: Virus Research
https://www.readbyqxmd.com/read/29727732/luffa-operculata-fruit-aqueous-extract-induces-motor-impairments-anxiety-like-behavior-and-testis-damage-in-rats
#8
Cinthia Dos S Alves, Humberto V Frias, Thiago B Kirsten, Flora Cordeiro, Maria M Bernardi, Ivana B Suffredini
ETHNOPHARMACOLOGICAL RELEVANCE: Luffa operculata (L.) Cogn., Cucurbitaceae (buchinha-do-norte), aqueous extract (EBN) is popularly used to relieve symptoms of sinusitis and as abortive. AIM OF THE STUDY: As neurotoxicity and toxicity studies on the male reproductive system are scarce, the present study aimed at quantitatively addressing the question. MATERIALS AND METHODS: Male adult rats were observed in the open field (OF) and in the light-dark box test (LDB) to evaluate locomotion and anxiety...
May 1, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29724465/shear-wave-elastography-evaluation-of-testes-with-non-communicating-hydrocele-in-infants-and-toddlers-a-preliminary-study
#9
C Kocaoglu, M S Durmaz, M Sivri
INTRODUCTION: Shear wave elastography (SWE) is a new technology and non-invasive ultrasound device that can measure tissue rigidity and elasticity. OBJECTIVE: This controlled prospective study aimed to demonstrate using SWE whether there was a difference between the elasticity of testes with non-communicating (NC) hydrocele in infants and toddlers and elasticity of controls' testes without hydrocele, and to reveal quantitative values of elasticity reflecting histological findings...
April 23, 2018: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/29710834/fish-oil-ameliorates-high-fat-diet-induced-male-mouse-reproductive-dysfunction-via-modifying-the-rhythmic-expression-of-testosterone-synthesis-related-genes
#10
Hualin Wang, Yazheng Cai, Yang Shao, Xifeng Zhang, Na Li, Hongyu Zhang, Zhiguo Liu
The present study aims to investigate the protective effects of ω-3 polyunsaturated fatty acids (ω-3PUFAs) against high-fat diet induced male mouse reproductive dysfunction and to explore circadian regulation mechanisms. Male C57BL/6 mice were randomly divided into three groups and fed a normal chow diet (control group, CON), a high-fat diet (HFD group) or a HFD supplemented with fish oil (FO group) for 12 weeks. After 12 weeks of feeding, the body weight and the ratio of perinephric and epididymal fat weight to body weight were significantly higher in the HFD group compared with the CON group...
April 29, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29681085/two-novel-cases-expanding-the-phenotype-of-setd2-related-overgrowth-syndrome
#11
Maartje C van Rij, Iris H I M Hollink, Paulien Anna Terhal, Sarina G Kant, Claudia Ruivenkamp, Arie van Haeringen, J Anneke Kievit, Martine J van Belzen
The SETD2-related overgrowth syndrome is also called "Luscan-Lumish syndrome" (OMIM 616831) with the clinical characteristics of intellectual disability, speech delay, macrocephaly, facial dysmorphism, and autism spectrum disorders. We report on two novel patients a 4.5-year-old boy and a 23-year-old female adolescent with a speech and language developmental delay, autism spectrum disorder and macrocephaly, who were both diagnosed with SETD2-related overgrowth syndrome due to de novo frameshift mutations in the SETD2 gene...
May 2018: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/29680294/klinefelter-syndrome-the-effects-of-early-androgen-therapy-on-competence-and-behavioral-phenotype
#12
REVIEW
Ryan Flannigan, Premal Patel, Darius A Paduch
INTRODUCTION: Klinefelter syndrome (KS) is the result of sex chromosome aneuploidy most often characterized as 47,XXY. The typical features of KS include tall stature, gynecomastia, small firm testicles, hypergonadotropic hypogonadism, and infertility. However, abnormalities in neurodevelopment, cognition, and social and behavioral functioning also can be present. The abnormalities in neurodevelopment are believed to be due in part to androgen deficiency during early development and puberty...
April 18, 2018: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/29674209/possible-mechanisms-underlying-fatty-liver-in-a-rat-model-of-male-hypogonadism-a-protective-role-for-testosterone
#13
Hussein F Sakr, Abdelaziz M Hussein, Elsayed A Eid, Mahmoud AlKhateeb
AIMS: To investigate the effects of testosterone (Test) deficiency and testosterone replacement therapy (TRT) on the development of non-alcoholic fatty liver disease (NAFLD) and associated peripheral insulin resistance (IR) in male rats and to illustrate the underlying mechanisms of action. MATERIALS AND METHODS: male Sprague Dawley rats were divided into 3 groups as follows: 1) sham-operated group (n=11), 2) ORCD-induced group (n=9) exposed to orchidectomy (ORCD), achieved by complete surgical removal of testicles, and 3) ORCD+ Test treated group (n=10) (11 ng/ mL Test propionate, 3x/week, S...
April 16, 2018: Steroids
https://www.readbyqxmd.com/read/29665032/testicular-choriocarcinoma-with-cutaneous-metastasis-in-a-19-year-old-man
#14
Ferdinand Toberer, Alexander Enk, Wolfgang Hartschuh, Carsten Grüllich
A 19-year-old man suffering from testicular choriocarcinoma presented to the dermatology department with a cutaneous metastasis on his head. This metastasis was the first sign of disease that led to medical consultation. Histopathology revealed cytotrophoblasts and syncytiotrophoblasts, the later expressing human chorionic gonadotropin antigen. Whole body computed tomography showed multiple metastases of the brain, lung, liver, bone, paraaortic lymph nodes and left uvea, the primary was found in the left testicle...
April 17, 2018: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29620658/scrotal-paragonimiasis-in-adults-two-case-reports-and-review-of-literature
#15
Tiancai Liang, Guobiao Liang, Yang Du, Xin Wang, Yuanliang Wang, Anjian Chen, Zongping Chen, Jiang Du, Hao Li, Lang Yu
RATIONALE: Paragonimiasis is a parasitic disease caused by Paragonimus in the lungs; it can be divided into intrapulmonary type and extrapulmonary type. Adult patients with scrotal paragnonimus are rarely seen clinically and not widely reported in the literature. Here, we report 2 cases of scrotal paragonimiasis in adults and their treatment process. PATIENT CONCERNS: Two young males sought medical advice because of scrotal masses. Both patients had the previous history of eating uncooked river crabs and presented with palpable quasicircular nodules of about 1...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29620548/age-at-presentation-of-undescended-testicles-a-single-center-study-in-saudi-arabia
#16
Jumanah H Basalelah, Abdullah M Alzahrani, Abdulaziz M Alshaibani, Nasser S Alalyani, Turki A Alsubiani, Maha Khalid AlMadi, Ossamah S Allsowayan
BACKGROUND: The undescended testis (UDT) is the most common genital anomaly encountered in pediatrics with an estimated incidence of 1% to 4% in full-term and 1% to 45% in preterm newborn boys. Over the years, studies on progressive histological deterioration and cancer risk has led to a change in recommendations for when orchidopexy should be done. OBJECTIVES: Determine age at presentation of patients for UDT to a specialist in Saudi Arabia, age of operation and whether the recommended targeted time frame has been met...
March 2018: Annals of Saudi Medicine
https://www.readbyqxmd.com/read/29611653/the-evaluation-of-blood-concentrations-of-testosterone-17%C3%AE-oestradiol-and-anti-mu%C3%A2-llerian-hormone-in-dogs-with-cryptorchidism-and-testicular-tumours
#17
L Hornakova, T Vrbovska, M Pavl'ak, A Valencakova-Agyagosova, M Halo, J Hajurka
Cryptorchidism and testicular tumours are very common disorders in dogs genitalia. The aim of the present study was o obtain an overview of serum 17β-oestradiol, anti-Muellerian hormone (AMH) and testosterone levels in intact dogs compared to dogs with different testicular tumours and dogs with cryptorchidism. Testosterone, AMH and 17β-oestradiol concentrations were measured in peripheral and local spermatic venous blood in dogs with unilateral cryptorchidism (n=8), dogs with neoplastic testicular diseases (n=8) and in a control group of mature intact dogs (n=8)...
December 2017: Polish Journal of Veterinary Sciences
https://www.readbyqxmd.com/read/29606731/estrogen-induced-myelotoxicity-in-a-4-year-old-golden-retriever-dog-due-to-a-sertoli-cell-tumor
#18
Hayden Marshall
A 4-year-old, unilateral cryptorchid golden retriever dog was presented to the Ontario Veterinary College Health Sciences Centre with gynecomastia, dribbling urine, lethargy, neutropenia, and thrombocytopenia. A Sertoli cell tumor was diagnosed in a cryptorchid testicle with estrogen-induced myelotoxicity. The tumor was removed and bone marrow regenerated within 4 months.
April 2018: Canadian Veterinary Journal. la Revue Vétérinaire Canadienne
https://www.readbyqxmd.com/read/29599748/polyostotic-fibrous-dysplasia-with-and-without-mccune-albright-syndrome-clinical-features-in-a-nordic-pediatric-cohort
#19
Pauliina Utriainen, Helena Valta, Sigridur Björnsdottir, Outi Mäkitie, Eva Horemuzova
Objective: Fibrous dysplasia (FD) presents as skeletal lesions in which normal bone is replaced by abnormal fibrous tissue due to mosaic GNAS mutation. McCune-Albright syndrome (MAS) refers to FD combined with skin (café-au-lait) and endocrine manifestations. This study describes the clinical childhood manifestations of polyostotic FD and MAS in a Nordic cohort. Patients and design: We retrospectively reviewed a cohort of pediatric patients ( n  = 16) with polyostotic FD with or without MAS diagnosed and followed in two Nordic Pediatric tertiary clinics between 1996 and 2017...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29599382/large-intra-abdominal-seminoma-in-a-left-undescended-testicle-complicated-by-torsion
#20
Elizabeth Rourke, Gilda Digman, Eric Gourley, Dharam Kaushik
A 39-year-old man presented with a 2-day history of worsening constant, dull diffuse lower abdominal pain with associated constipation and known history of left undescended testicle. He was evaluated at an outside hospital where a non-contrasted CT scan revealed a 20 cm well-circumscribed soft tissue mass within the pelvis.He was referred and further imaging revealed a 12 cm heterogeneous mass with foci of air that appeared to be contiguous with the left spermatic cord. This constellation of findings could represent torsion of undescended left testicle with infarction or underlying malignancy...
March 28, 2018: BMJ Case Reports
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