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Probiotic stimulator interleukin 10

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https://www.readbyqxmd.com/read/27892709/gut-borne-saccharomyces-cerevisiae-a-promising-candidate-for-the-formulation-of-feed-additives-modulates-immune-system-and-gut-microbiota
#1
G García, C Dogi, A de Moreno de LeBlanc, C Greco, L Cavaglieri
The aim was to evaluate the effect of Saccharomyces cerevisiae RC016 on immune parameters and gut microbiota in healthy mice. Animals received S. cerevisiae RC016 for 10 days. Microbial translocation to liver and changes in some bacterial populations in caecum were determined. Immune stimulation was assessed at gut level (measure ofimmunoglobulin A (IgA)(+) cells and luminal cytokine profile) and by evaluating the activity of peritoneal macrophages. Oral administration of S. cerevisiae RC016 did not induce microbial translocation to liver...
November 30, 2016: Beneficial Microbes
https://www.readbyqxmd.com/read/27873545/presence-of-lactobacillus-reuteri-in-saliva-coincide-with-higher-salivary-iga-in-young-adults-after-intake-of-probiotic-lozenges
#2
G Braathen, V Ingildsen, S Twetman, D Ericson, M R Jørgensen
The aim of this study was to compare the concentration of salivary immunoglobulin A (IgA) and the selected interleukins (IL)-1β, IL-6, IL-8 and IL-10 in young individuals with presence and non-presence of Lactobacillus reuteri in saliva after a three-week intervention with probiotic lozenges. The study group consisted of 47 healthy individuals aged 18-32 years with no clinical signs of oral inflammation. In a randomised, double-blind, placebo-controlled, cross-over trial participants ingested two lozenges per day containing two strains of the probiotic bacterium L...
November 22, 2016: Beneficial Microbes
https://www.readbyqxmd.com/read/27824645/a-single-species-of-clostridium-subcluster-xiva-decreased-in-ulcerative-colitis-patients
#3
Kozue Takeshita, Shinta Mizuno, Yohei Mikami, Tomohisa Sujino, Keiichiro Saigusa, Katsuyoshi Matsuoka, Makoto Naganuma, Tadashi Sato, Toshihiko Takada, Hirokazu Tsuji, Akira Kushiro, Koji Nomoto, Takanori Kanai
BACKGROUND: Imbalance of the intestinal microbiota is associated with gastrointestinal disease and autoimmune disease and metabolic syndrome. Analysis of the intestinal microbiota has recently progressed, and the association with inflammatory bowel disease has been reported at the species level. Such findings suggest that the recovery of homeostasis in the intestinal microbiota could cure inflammatory bowel disease. We aimed to search new probiotic candidates for inflammatory bowel disease through translational research by analysis of ulcerative colitis (UC) patients' intestinal microbiota and clarify the effects of them on inflammation...
November 7, 2016: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/27600362/lactobacillus-sakei-k17-an-inducer-of-il-10-expression-in-antigen-presenting-cells-attenuates-tnbs-induced-colitis-in-mice
#4
Su-Hyeon Eun, Su-Min Lim, Se-Eun Jang, Myung Joo Han, Dong-Hyun Kim
To understand the anti-colitic effects of probiotics that up-regulate interleukin (IL)-10 expression in dendritic cells (DCs) and macrophages, we isolated Lactobacillus sakei K17, which potently induced IL-10 expression in DCs and peritoneal macrophages in vitro, among the lactic acid bacteria strains collected from kimchi and investigated its anti-inflammatory effect in mice with 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis. Oral administration of K17 (2 × 10(9) CFU·mouse(-1)·day(-1)) in mice with TNBS-induced colitis suppressed colon shortening and myeloperoxidase activity, as well as infiltration of CD86(+) cells into the colon...
September 7, 2016: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/27363733/lactobacillus-helveticus-lafti-l10-supplementation-reduces-respiratory-infection-duration-in-a-cohort-of-elite-athletes-a-randomized-double-blind-placebo-controlled-trial
#5
Danica Michalickova, Rajna Minic, Nenad Dikic, Marija Andjelkovic, Marija Kostic-Vucicevic, Tamara Stojmenovic, Ivan Nikolic, Brizita Djordjevic
A randomized, double-blind, placebo-controlled study was conducted to evaluate if Lactobacillus helveticus Lafti L10 (Lallemand Health Solutions, Montreal, Que., Canada) supplementation during 14 weeks in winter can influence the duration, severity, and incidence of upper respiratory tract illness (URTI), as well as to monitor different immune parameters in the population of elite athletes. Before and after the treatment, cardiopulmonary testing and self-rated state of moods evaluation (by Profile of Mood States questionnaire) were performed and blood samples were collected...
July 2016: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/27048833/lactobacillus-rhamnosus-rc007-intended-for-feed-additive-immune-stimulatory-properties-and-ameliorating-effects-on-tnbs-induced-colitis
#6
C Dogi, G García, A De Moreno de LeBlanc, C Greco, L Cavaglieri
Lactobacillus rhamnosus RC007 is a potential probiotic bacterium that can exert beneficial effects as supplement for animal feed, by improving the immune status in healthy host, and by providing therapeutic benefits to infected/inflamed animals. The aim of the present work was to evaluate in vivo the beneficial properties of L. rhamnosus RC007, intended for animal feed, when administered to healthy and trinitro-benzene-sulfonic-acid (TNBS) colitis induced BALB/c mice. The administration of L. rhamnosus RC007 to healthy mice during 10 days increased the phagocytic activity of peritoneal macrophages and the number of immunoglobulin A+ cells in the lamina proper of the small intestine...
September 2016: Beneficial Microbes
https://www.readbyqxmd.com/read/27001279/lactobacillus-sakei-ok67-ameliorates-high-fat-diet-induced-blood-glucose-intolerance-and-obesity-in-mice-by-inhibiting-gut-microbiota-lipopolysaccharide-production-and-inducing-colon-tight-junction-protein-expression
#7
Su-Min Lim, Jin-Ju Jeong, Kyung Hee Woo, Myung Joo Han, Dong-Hyun Kim
A high-fat diet (HFD) induces obesity and the associated increases in blood glucose and inflammation through changes in gut microbiota, endotoxemia, and increased gut permeability. To counteract this, researchers have suggested that the use of probiotics that suppress production of proinflammatory lipopolysaccharide (LPS). Here, we tested whether Lactobacillus sakei OK67, which inhibits gut microbiota LPS production selected from among the lactic acid bacteria isolated from kimchi, exerted antihypoglycemic or anti-inflammatory effects in HFD-fed mice...
April 2016: Nutrition Research
https://www.readbyqxmd.com/read/26876356/heat-killed-whole-cell-products-of-the-probiotic-pseudomonas-aeruginosa-vsg2-strain-affect-in%C3%A2-vitro-cytokine-expression-in-head-kidney-macrophages-of-labeo-rohita
#8
Sib Sankar Giri, Shib Sankar Sen, Jin Woo Jun, Se Chang Park, V Sukumaran
Present study was undertaken to investigate the efficiency of heat-killed whole-cell products (HKWCPs) of probiotic Pseudomonas aeruginosa VSG2 strain in stimulating the cytokine responses in the head kidney (HK) macrophages of Labeo rohita. The HK macrophages were incubated with HKWCPs or lipopolysaccharide (LPS), and the responses of cytokine genes, namely interleukin-10 (IL-10), IL-1β, IL-p35, IL-12p40, tumour necrosis factor-α (TNF-α), nuclear factor kappa B (NF-κB), cyclooxygenase-2 (COX-2), interferon-alpha (IFN-α), and interferon-gamma (IFN-γ) were assessed by quantitative real-time PCR (qRT-PCR) at 2, 8, 16, 24, 48, 72 h post-stimulation (hps)...
March 2016: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/26689225/interaction-of-mouse-splenocytes-and-macrophages-with-bacterial-strains-in-vitro-the-effect-of-age-in-the-immune-response
#9
A A Van Beek, J A Hoogerland, C Belzer, P De Vos, W M De Vos, H F J Savelkoul, P J M Leenen
Probiotics influence the immune system, both at the local and systemic level. Recent findings suggest the relation between microbiota and the immune system alters with age. Our objective was to address direct effects of six bacterial strains on immune cells from young and aged mice: Lactobacillus plantarum WCFS1, Lactobacillus casei BL23, Lactococcus lactis MG1363, Bifidobacterium breve ATCC15700, Bifidobacterium infantis ATCC15697, and Akkermansia muciniphila ATCC BAA-835. We used splenocytes and naïve or interferon-γ-stimulated bone marrow-derived macrophages (BMDM) as responder populations...
2016: Beneficial Microbes
https://www.readbyqxmd.com/read/26520566/effects-of-intracellular-products-of-bacillus-subtilis-vsg1-and-lactobacillus-plantarum-vsg3-on-cytokine-responses-in-the-head-kidney-macrophages-of-labeo-rohita
#10
Sib Sankar Giri, Shib Sankar Sen, Cheng Chi, Hyoun Joong Kim, Saekil Yun, Se Chang Park, V Sukumaran
The efficiency of intracellular products (ICPs) of the probiotics Bacillus subtilis VSG1 and Lactobacillus plantarum VSG3 in stimulating cytokine responses in the head kidney (HK) macrophages of Labeo rohita was investigated. The HK macrophages were incubated with ICPs and lipopolysaccharide (LPS), and the responses of cytokine genes, namely interleukin-10 (IL-10), IL-1β, IL-12p35, IL-12p40, IL-18, tumour necrosis factor-α (TNF-α), nuclear factor kappa B (NF-κB), cyclo-oxygenase-2 (COX-2), interferon-1 (IFN-1), and IFN-γ were assessed by quantitative real-time PCR (qRT-PCR) at 2, 6, 12, 24, and 48 h post-stimulation (hps)...
December 2015: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/25978374/lactobacillus-fermentum-zyl0401-attenuates-lipopolysaccharide-induced-hepatic-tnf-%C3%AE-expression-and-liver-injury-via-an-il-10-and-pge2-ep4-dependent-mechanism
#11
Pengfeng Jin, Yunbo Chen, Longxian Lv, Jianzhuan Yang, Haifeng Lu, Lanjuan Li
Lipopolysaccharide (LPS) has essential role in the pathogenesis of D-galactosamine-sensitized animal models and alcoholic liver diseases of humans, by stimulating release of pro-inflammatory mediators that cause hepatic damage and intestinal barrier impairment. Oral pretreatment of probiotics has been shown to attenuate LPS-induced hepatic injury, but it is unclear whether the effect is direct or due to improvement in the intestinal barrier. The present study tested the hypothesis that pretreatment with probiotics enables the liver to withstand directly LPS-induced hepatic injury and inflammation...
2015: PloS One
https://www.readbyqxmd.com/read/25909149/lactobacillus-gasseri-ks-13-bifidobacterium-bifidum-g9-1-and-bifidobacterium-longum-mm-2-ingestion-induces-a-less-inflammatory-cytokine-profile-and-a-potentially-beneficial-shift-in-gut-microbiota-in-older-adults-a-randomized-double-blind-placebo-controlled
#12
RANDOMIZED CONTROLLED TRIAL
Samuel J Spaiser, Tyler Culpepper, Carmelo Nieves, Maria Ukhanova, Volker Mai, Susan S Percival, Mary C Christman, Bobbi Langkamp-Henken
OBJECTIVE: This study determined whether older adults who consumed a probiotic mixture would have a greater proportion of circulating CD4+ lymphocytes, altered cytokine production, and a shift in intestinal microbiota toward a healthier microbial community. METHODS: Participants (70 ± 1 years [mean ± SEM]; n = 32) consumed a probiotic (Lactobacillus gasseri KS-13, Bifidobacterium bifidum G9-1, and Bifidobacterium longum MM2) or a placebo twice daily for 3 weeks with a 5-week washout period between intervention periods...
2015: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/25485483/the-in-vitro-immunomodulatory-effect-of-extracellular-products-ecps-of-vagococcus-fluvialis-l21-on-european-sea-bass-dicentrarchus-labrax-leucocytes
#13
L Román, F Acosta, D Padilla, F El Aamri, J Bravo, B Vega, E Rodriguez, J Vega, S Déniz, F Real
The immune associated genes, interleukin-1β (IL-1β), interleukin-6 (IL-6), interleukin 10 (IL-10), tumor necrosis factor-α (TNF-α), ciclo-oxigenase-2 (COX-2), and Mx gene were studied by real-time PCR in head-kidney leucocytes of sea bass after incubation with the extracellular products (ECPs) of the probiotic strain Vagococcus fluvialis L21 and polyinosinic:polycytidylic acid (POLY I:C), at different times (T1.5, T6, T12, T24, T48 and T72). In general, we can observe how pro-inflammatory cytokines IL-1β, TNF-α, IL-6 and COX-2 studied displayed a strong peak after stimulation with 1...
February 2015: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/25116382/heat-killed-probiotic-bacteria-differentially-regulate-colonic-epithelial-cell-production-of-human-%C3%AE-defensin-2-dependence-on-inflammatory-cytokines
#14
N Habil, W Abate, J Beal, A D Foey
The inducible antimicrobial peptide human β-defensin-2 (hBD-2) stimulated by pro-inflammatory cytokines and bacterial products is essential to antipathogen responses of gut epithelial cells. Commensal and probiotic bacteria can augment such mucosal defences. Probiotic use in the treatment of inflammatory bowel disease, however, may have adverse effects, boosting inflammatory responses. The aim of this investigation was to determine the effect of selected probiotic strains on hBD-2 production by epithelial cells induced by pathologically relevant pro-inflammatory cytokines and the role of cytokine modulators in controlling hBD-2...
December 2014: Beneficial Microbes
https://www.readbyqxmd.com/read/25013357/anti-inflammatory-and-intestinal-barrier-protective-activities-of-commensal-lactobacilli-and-bifidobacteria-in-thoroughbreds-role-of-probiotics-in-diarrhea-prevention-in-neonatal-thoroughbreds
#15
Soichi Tanabe, Takuya Suzuki, Yuichiro Wasano, Fumihiko Nakajima, Hiroshi Kawasaki, Tomonori Tsuda, Natsuko Nagamine, Takashi Tsurumachi, Kiyoshi Sugaya, Hiroaki Akita, Misako Takagi, Kunihiko Takagi, Yoshinobu Inoue, Yo Asai, Hidetoshi Morita
We previously isolated the commensal bacteria lactobacilli and bifidobacteria from the Thoroughbred intestine and prepared the horse probiotics LacFi(TM), consisting of Lactobacillus ruminis KK14, L. equi KK 15, L. reuteri KK18, L. johnsonii KK21, and Bifidobacterium boum HU. Here, we found that the five LacFi(TM) constituent strains remarkably suppressed pro-inflammatory interleukin-17 production in mouse splenocytes stimulated with interleukin-6 and transforming growth factor-β. The protective effects of the probiotic on impaired intestinal barrier function were evaluated in Caco-2 cells treated with tumor necrosis factor-α...
2014: Journal of Equine Science
https://www.readbyqxmd.com/read/24939801/effect-of-intestinal-colonisation-by-two-lactobacillus-strains-on-the-immune-response-of-gnotobiotic-mice
#16
R S Steinberg, M Lima, N L Gomes de Oliveira, A Miyoshi, J R Nicoli, E Neumann, A C Nunes
The effect of intestinal colonisation on the immune system was investigated in germ-free mice monoassociated with Lactobacillus strains isolated from calf faeces. Single doses of Lactobacillus acidophilus L36 or Lactobacillus salivarius L38 were administered to germ-free mice by intragastric gavage. Ten days later, the mice were euthanised. Gene expression levels of interleukin 5 (IL-5), IL-6, IL-10, IL-12b, IL-17a, gamma interferon (IFN-γ), transforming growth factor beta 1 (TGF-β1), and tumour necrosis factor alpha (TNF-α) were quantified in segments of the small and large intestines by real time quantitative polymerase chain reaction...
December 2014: Beneficial Microbes
https://www.readbyqxmd.com/read/24913839/differential-effects-of-lactobacilli-on-activation-and-maturation-of-mouse-dendritic-cells
#17
I Elawadli, J T Brisbin, B A Mallard, M W Griffiths, M Corredig, S Sharif
Lactic acid bacteria (LAB) are of interest because of their potential to modulate immune responses. The effects of LAB range from regulation to stimulation of the immune system. A series of studies were performed in vitro to study the effects of six lactic acid bacteria (LAB), Lactobacillus helveticus LH-2, Lactobacillus acidophilus La-5, La-115, La-116 and La-14, and Lactobacillus salivarius, on maturation and activation of mouse dendritic cells. Production of tumour necrosis factor (TNF)-?, interleukin (IL)-6 and IL-10 by dendritic cells (DCs) was determined after treating cells with live LAB...
September 2014: Beneficial Microbes
https://www.readbyqxmd.com/read/24860569/modulation-of-respiratory-tlr3-anti-viral-response-by-probiotic-microorganisms-lessons-learned-from-lactobacillus-rhamnosus-crl1505
#18
REVIEW
Haruki Kitazawa, Julio Villena
Respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract illness in infants and young children. Host immune response is implicated in both protective and immunopathological mechanisms during RSV infection. Activation of Toll-like receptor (TLR)-3 in innate immune cells by RSV can induce airway inflammation, protective immune response, and pulmonary immunopathology. A clear understanding of RSV-host interaction is important for the development of novel and effective therapeutic strategies...
2014: Frontiers in Immunology
https://www.readbyqxmd.com/read/24815859/lactobacillus-plantarum-clp-0611-ameliorates-colitis-in-mice-by-polarizing-m1-to-m2-like-macrophages
#19
Se-Eun Jang, Myung Joo Han, Se-Young Kim, Dong-Hyun Kim
The TNF-α expression-inhibitory effect of lactic acid bacteria (LAB) isolated from kimchi were measured in lipopolysaccharide (LPS)-stimulated peritoneal macrophages. Among the LAB evaluated, Lactobacillus plantarum CLP-0611 inhibited the IL-1β and IL-6 expression, as well as the NF-κB and AP1 activation in LPS-stimulated peritoneal macrophages. Therefore, we investigated its inhibitory effect on 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis in mice. TNBS significantly induced colon shortening, as well as myeloperoxidase activity and macroscopic score...
July 2014: International Immunopharmacology
https://www.readbyqxmd.com/read/24814797/host-responses-to-the-pathogen-mycobacterium-avium-subsp-paratuberculosis-and-beneficial-microbes-exhibit-host-sex-specificity
#20
Enusha Karunasena, K Wyatt McMahon, David Chang, Mindy M Brashears
Differences between microbial pathogenesis in male and female hosts are well characterized in disease conditions connected to sexual transmission. However, limited biological insight is available on variances attributed to sex specificity in host-microbe interactions, and it is most often a minimized variable outside these transmission events. In this work, we studied two gut microbes-a pathogen, Mycobacterium avium subsp. paratuberculosis, and a probiotic, Lactobacillus animalis NP-51-and the interaction between each agent and the male and female gastrointestinal systems...
August 2014: Applied and Environmental Microbiology
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