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Nonhodgkin lymphoma

Amen Ahmed Bawazir
BACKGROUND: This study aims to report on the trend and incidence of cancers in Yemen (Aden) using data from Aden Cancer Registry (ACR), as a population-based cancer registry in Yemen over a period of 15 years (1997-2011). Such comprehensive, valid and detailed information on cancer trend is badly needed for planning a cancer control program in the country. METHODS: All cancer cases were abstracted from patients' medical records - based on clinical, histopathology, and radiological diagnosis...
May 8, 2018: BMC Cancer
Lucka Boltezar, Ivana Zagar, Barbara Jezersek Novakovic
BACKGROUND: Sarcoidosis before and after treatment of malignancy is an important differential diagnosis that has to be distinguished from lymphoma. PATIENTS AND METHODS: Hodgkin lymphoma, diffuse large B-cell lymphoma and aggressive follicular lymphoma are being staged and treatment effect is evaluated with PET-CT. We report three cases of aggressive lymphoma after high dose therapy and autologous stem cell transplantation with positive lymph nodes on PET-CT, which were histologically diagnosed as sarcoidosis/granulomatosis...
December 1, 2016: Radiology and Oncology
Aysel Topan, Dilek Bayram, Mustafa Özendi, Ali Cam, Özlem Öztürk, Tülay Kuzlu Ayyıldız, Hülya Kulakçı, Funda Veren
The main objective of this research is to examine child cancer cases in Zonguldak/Turkey descriptively in epidemiological aspect with the help of GIS. Universe of the study is composed of 60 children between 1 and 19 years old who were treated in Children Oncology Clinic with a diagnosis of cancer. Whole universe was reached without selecting a sample in the study. Data were collected by using a form prepared by obtaining expert advice and they were applied to children and their parents at study dates. Results were expressed as percentages...
October 2016: Journal of Medical Systems
Phunnipit Wongmeerit, Krittika Suwanrungruang, Arunee Jetsrisuparb, Patcharee Komvilaisak, Surapon Wiangnon
BACKGROUND: In Thailand, a national treatment protocol for childhood leukemia and lymphoma (LL) was implemented in 2006. Access to treatment has also improved with the National Health Security system. Since these innovations, survival of childhood LL has not been fully described. MATERIALS AND METHODS: Trends and survival of children under 15 with childhood cancers diagnosed between 1993 and 2012 were investigated using the hospitalbased data from the Khon Kaen Cancer Registry, Srinagarind Hospital, Faculty of Medicine, Khon Kaen University, Thailand...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
Fadia Elias, Fadlo R Khuri, Salim M Adib, Rita Karam, Hilda Harb, May Awar, Pierre Zalloua, Walid Ammar
BACKGROUND: The Ministry of Public Health (MOPH) in Lebanon provides cancer drugs free of charge for uninsured patients who account for more than half the total caseload. Other categories of cancer care are subsidized under more stringent eligibility criteria. MOPH's large database offers an excellent opportunity to analyze the cost of cancer treatment in Lebanon. MATERIALS AND METHODS: Using utilization and spending data accumulated at MOPH during 20082013, the cost to the public budget of cancer drugs was assessed per case and per drug type...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
Raja Senthil, Ranjan Kumar Mohapatra, Mouleeswaran Koramadai Sampath, Sumati Sundaraiya
Anaplastic large cell lymphoma (ALCL) is a rare type of nonHodgkin's lymphoma (NHL), but one of the most common subtypes of T-cell lymphoma. It is an aggressive T-cell lymphoma, and some ALCL may mimic less aggressive classical HL histopathlogically. It may be misdiagnosed unless careful immunohistochemical examination is performed. As the prognosis and management of these two lymphomas vary significantly, it is important to make a correct diagnosis. We describe a case who was diagnosed as classical HL by histopathological examination of cervical lymph node, in whom (18)F-flouro deoxyglucose positron emission tomography/computed tomography appearances were unusual for HL and warranted review of histopathology that revealed anaplastic lymphoma kinase-1 negative anaplastic large T-cell lymphoma, Hodgkin-like variant, thereby changing the management...
January 2016: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
P Klener, M Trněný
BACKGROUND: Mantle cell lymphoma represents a specific subtype of B -cell non-Hodgkin lymphoma characterized on the molecular level by translocation t(11;14)(q13;q32) leading to aberrant overexpression of cyclin D1 and deregulation of the cell cycle. Despite sporadic indolent forms of mantle cell lymphoma, majority of patients present with advanced aggressive disease that requires immediate treatment. Despite chemosensitive nature of mantle cell lymphoma, approximately 10% patients present with a refractory disease, and the vast majority of patients who initially respond to therapy, relapse sooner or later...
2015: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
Anil Khurana, Paramjeet Kaur, Ashok K Chauhan, Sant Parkash Kataria, Nupur Bansal
Primary adrenal lymphoma is rare and constitutes for 3% of extranodal lymphoma cases. Approximately 70% of patients present with bilateral disease and have adrenal insufficiency. Prognosis of primary adrenal lymphoma (PAL) is poor, most of patient die within one year of diagnosis. Moreover, there are no standard treatment protocols on such cases. Patients are generally treated with regimens similar to other nonhodgkin lymphoma which includes surgery, combination chemotherapy and or radiotherapy. We are presenting a successfully treated case of primary diffuse large B cell non Hodgkin lymphoma of adrenal gland in a 57-year-old patient...
April 2015: Journal of Clinical and Diagnostic Research: JCDR
Michael L Eisenberg, Shufeng Li, James D Brooks, Mark R Cullen, Laurence C Baker
PURPOSE: Aberrations in reproductive fitness may be a harbinger of medical diseases in men. Data suggest a higher risk of testicular cancer in infertile men. However, the relationship between infertility and other cancers remains uncertain. MATERIALS AND METHODS: We analyzed subjects from the Truven Health MarketScan® claims database from 2001 to 2009. Infertile men were identified through diagnosis and treatment codes. Comparison groups were created of men who underwent vasectomy and a control cohort of men who were not infertile and had not undergone vasectomy...
May 2015: Journal of Urology
Archie Bleyer, Barbara L Asselin, Susannah E Koontz, Stephen P Hunger
Asparaginase, an enzyme used to treat acute lymphoblastic leukemia and related forms of nonHodgkin lymphoma, depletes asparagine, which leads to lymphoblast cell death. Unlike most chemotherapeutic agents, asparaginase is a foreign protein that can result in clinical allergy and/or silent hypersensitivity with production of neutralizing antibodies that inactivate asparaginase. In North America, asparaginase activity levels can now be obtained via a commercially available assay, for therapeutic drug monitoring and investigation of potential allergic reactions...
June 2015: Pediatric Blood & Cancer
Pavan Tiwari, Karan Madan, Deepali Jain, Rakesh Kumar, Anant Mohan, Randeep Guleria
A young male patient had been evaluated for pleural effusion at another center wherein on the basis of exudative, lymphocyte predominant pleural effusion with high pleural fluid adenosine deaminase (ADA) levels and tuberculin skin test (TST) reactivity, antituberculous medications had been administered. Reevaluation in view of worsening symptoms led to confirmation of the diagnosis of T-cell lymphoblastic lymphoma with pleuro-peritoneal lymphomatosis and tonsillar involvement. This case highlights the fact that elevated ADA levels should not be taken as surrogate for a diagnosis of TB in the absence of histopathological/microbiological confirmation even in countries with high tuberculosis (TB) prevalence...
October 2014: Lung India: Official Organ of Indian Chest Society
Masahito Tsurusawa, Masahiko Gosho, Tetsuya Mori, Tetsuo Mitsui, Shosuke Sunami, Ryoji Kobayashi, Reiji Fukano, Fumiko Tanaka, Naoto Fujita, Hiroko Inada, Katsuyoshi Koh, Tetsuya Takimoto, Akiko Saito, Junichiro Fujimoto, Atsuko Nakazawa, Keizo Horibe
BACKGROUND: Plasma monitoring of Methotrexate (MTX) levels is a standard approach to predict MTX-related toxicities in a high-dose (HD) MTX monotherapy for childhood acute lymphoblastic leukemia. However, it is uncertain whether plasma MTX levels can predict MTX-related toxicity in the HDMTX plus additional chemotherapy for childhood B-cell nonHodgkin lymphoma (B-NHL). PROCEDURES: To statistically analyze the relationship between MTX pharmacokinetic parameters and MTX-related toxicities, we collected data from patients with delayed MTX elimination (≥1 µM at 48 hr and/or ≥0...
February 2015: Pediatric Blood & Cancer
Salem Al Shemmari, Sreedharan P Sankaranarayanan, Yamini Krishnan
OBJECTIVE: PMBCL is a distinct type of nonhodgkins lymphoma with specific clinicopathological features. To clarify clinical features, treatment alternatives and outcomes, we evaluated 28 Arab patients treated with chemotherapy or radiotherapy between 2006 and 2011. PATIENTS AND METHODS: PMBCL lymphoma patients identified according to WHO classification and treated at KCCC between 2006 and 2011 were included in this study. Demographic and clinical data are presented as means or medians...
July 2014: Lung India: Official Organ of Indian Chest Society
Rakesh Kumar Manne, Chandra Sekhar Madu, Harsh Vardhan Talla
Burkitt's lymphoma (BL) is the fastest growing malignancy of the lymphoreticular system to affect humans and has a potential ability to double in size every day. A case of maxillary sporadic BL (sBL) associated with neuro-orbital involvement in an Indian male is presented. sBL initially presented as maxillary swelling with no obvious dental and periodontal changes. Histological specimen from incisional biopsy revealed a round cell malignant tumor and immunohistochemistry reactions favored nonHodgkin's lymphoma consistent with BL...
April 2014: Contemporary Clinical Dentistry
E Curakova, M Genadieva-Dimitrova, J Misevski, V Caloska-Ivanova, V Andreevski, B Todorovska, U Isahi, M Trajkovska, P Misevska, N Joksimovic, S Genadieva-Stavric, S Antovic, N Jankulovski
The gastrointestinal tract is the most common extranodal site involved with lymphoma accounting for 5-20% of all cases. Lymphoma can occur at any site of the body, but diffuse and extensive involvement of the peritoneal cavity is unusual and rare. We report a case of diffuse large B-cell lymphoma in a 57-year-old female infiltrating the peritoneum and omentum and presenting with ascites and pleural effusion. The performed examinations did not discover any pathological findings affecting the digestive tract or parenchymal organs, except for diffuse thickening of the peritoneum and omentum...
2014: Case Reports in Gastrointestinal Medicine
Jitendra G Nasit, Maulin Patel, Biren Parikh, Manoj Shah, Kajal Davara
BACKGROUND: Mediastinal tumors are an uncommon abnormalities found in clinical practice. Anterior mediastinum is the common site and tissue diagnoses of anterior mediastinal masses (AMMs) are very important for correct therapeutic decision. OBJECTIVE: We evaluate the different malignant AMMs in various age groups and the sensitivity of fine needle aspiration cytology (FNAC) and core needle biopsy (CNB). Cytology smears are reviewed with particular emphasis on pitfalls in the cytological diagnosis...
January 2013: South Asian Journal of Cancer
Amara J Nidimusili, Naseem Eisa, Khaldoon Shaheen
CONTEXT: Kaposi's sarcoma (KS) is the most common neoplasm in patients with acquired immune deficiency syndrome (AIDS). Gastrointestinal (GI) involvement with KS commonly occurs in association with cutaneous lesions or lymph node involvement, with GI tract involvement alone occurring in only 3.5% of cases. There are several case reports described in the literature about asymptomatic intestinal KS with skin manifestations. Although GI KS is usually asymptomatic, hemorrhages from the oral cavity, esophagus, stomach, and large bowel have been reported in this disease...
November 2013: North American Journal of Medical Sciences
P Drastich
Small intestinal dysplastic lesions are rare and difficult to detect before they progress to cancer. New investigative modalities, such as capsule endoscopy and doubleballoon enteroscopy, are very promising in search for premalignant lesions. Screening patients at high-risk for small bowel neoplasia is the only sensible approach. Duodenal adenoma represents the most easily accessible tumors with the possibility of curative endoscopic resection. Due to the strong association of the small bowel and colonic adenomas, it is always necessary to perform colonoscopy...
2013: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
N A Awolola, A O Komolafe, O O Ojo, O J Taiwo, W O Odesanmi, K O Ajumobi
BACKGROUND: Geographic pathology is an accepted basis for unravelling trends of disease patterns. Proper documentation at the initial stage assists in establishing a foundation data. The authors are not aware of a documented pattern of malignant neoplasm in Ekiti State. OBJECTIVE: The aim of this study is to update the available literature on malignant neoplasms and compare our findings with previous work done by other investigators. METHODS: The estimates are based on a systematic retrospective survey of cancer cases identified in the Pathology Laboratories of Federal Medical Centre, Ido-Ekiti and University Teaching Hospital, Ado-Ekiti for the period; January 2002 to December 2009...
October 2011: Nigerian Quarterly Journal of Hospital Medicine
Victor Klimyuk, Gregory Pogue, Stefan Herz, John Butler, Hugh Haydon
This review describes the adaptation of the plant virus-based transient expression system, magnICON(®) for the at-scale manufacturing of pharmaceutical proteins. The system utilizes so-called "deconstructed" viral vectors that rely on Agrobacterium-mediated systemic delivery into the plant cells for recombinant protein production. The system is also suitable for production of hetero-oligomeric proteins like immunoglobulins. By taking advantage of well established R&D tools for optimizing the expression of protein of interest using this system, product concepts can reach the manufacturing stage in highly competitive time periods...
2014: Current Topics in Microbiology and Immunology
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