keyword
https://read.qxmd.com/read/38464471/csmyb73-negatively-regulates-theanine-accumulation-mediated-by-csggt2-and-csggt4-in-tea-shoots-camellia-sinensis
#1
JOURNAL ARTICLE
Manman Chang, Ying Sun, Kangzhi Fang, Maoyin Fu, Jingyu Ma, Yang Gao, Qi Chen, Linlin Liu, Zhaoliang Zhang, Xiaochun Wan, Jun Sun
Theanine metabolism is a necessary biological process during the planting and production of tea that determines tea quality. There is currently little knowledge about the transcriptional regulation of theanine metabolism in tea plants. In this study, we demonstrated that γ-glutamyl-transpeptidase CsGGT4, as a homologous protein of the theanine hydrolase CsGGT2, exhibited a higher theanine synthesis catalytic efficiency. Homology modeling and molecular docking showed that differential protein structures between CsGGT2 and CsGGT4 implied their different biological functions in tea plants...
March 2024: Horticulture Research
https://read.qxmd.com/read/38438008/l-theanine-attenuates-h-2-o-2-induced-inflammation-and-apoptosis-in-ipec-j2-cells-via-inhibiting-p38%C3%A2-mapk-signaling-pathway
#2
JOURNAL ARTICLE
Zhongqing Li, Zhiqing Huang, Gang Jia, Hua Zhao, Guangmang Liu, Xiaoling Chen
This study investigated the protective effects of L-theanine on hydrogen peroxide (H2 O2 )-induced intestinal barrier dysfunction in IPEC-J2 cells. Results showed that L-theanine reduced H2 O2 -induced IPEC-J2 cells inflammation and apoptosis, and decreased protein phosphorylation levels of p38 mitogen-activated protein kinase (p38 MAPK) and nuclear factor kappa-B (NF-κB). The p38 MAPK inhibitor (SB203580) decreased oxidative stress, the protein expression of phosphorylation of p38 MAPK and NF-κB, the H2 O2 -induced increase in mRNA expression of pro-apoptotic and pro-inflammatory related genes expression and secretion, and tight junction protein related genes expression, which was similar to the effect of L-theanine...
March 2, 2024: Food and Chemical Toxicology
https://read.qxmd.com/read/38435100/preparation-of-transdermal-gel-containing-l-theanine-for-the-potential-treatment-of-premenstrual-syndrome-a-preclinical-study
#3
JOURNAL ARTICLE
Kaana Ando, Ikumi Sugiyama, Yasuyuki Sadzuka
BACKGROUND: Premenstrual syndrome (PMS) is experienced by many women who suffer from either its psychological or physical symptoms. Current treatment is limited to symptomatic therapy or oral contraceptives. On the other hand, l-theanine, which has a relaxant effect, has been reported to be useful for PMS, but its short half-life when administered orally makes it less effective. Permeability and properties of transdermal gel containing l-theanine were evaluated as a preclinical study of PMS symptoms relief formulation...
2024: Women's health reports
https://read.qxmd.com/read/38434286/pyruvate-is-modified-by-tea-coffee-metabolites-and-reversely-correlated-with-multiple-system-atrophy-and-parkinson-s-disease
#4
JOURNAL ARTICLE
Xu-Ying Li, Teng Xue, Hong Lai, Jing Dai, Fangda Peng, Fanxi Xu, Junge Zhu, Xian Li, Junya Hu, Wei Li, Raoli He, Lina Chen, Ying Chen, Chunguang Ding, Guoguang Zhao, Xianyang Chen, Qinyong Ye, Zhiheng Xu, Chaodong Wang
INTRODUCTION: Multiple system atrophy (MSA) is a rapidly progressing neurodegenerative disorder. Although diverse biomarkers have been established for Parkinson's disease (PD), no widely accepted markers have been identified in MSA. Pyruvate and lactate are the end-product of glycolysis and crucial for brain metabolism. However, their correlation with MSA remains unclear. Moreover, it is elusive how lifestyles modify these metabolites. METHODS: To investigate the correlation and diagnostic value of plasma pyruvate and lactate levels in MSA and PD...
March 15, 2024: Heliyon
https://read.qxmd.com/read/38417334/integrated-transcriptomic-and-metabolomic-analyses-reveal-potential-regulatory-pathways-regulating-bone-metabolism-pre-and-postsexual-maturity-in-hens
#5
JOURNAL ARTICLE
Qiaoxian Yue, Chenxuan Huang, Rongyan Zhou, Yinlang Zhang, Dehe Wang, Zhenhong Zhang, Hui Chen
At the onset of sexual maturity, the increasing circulating estrogen stimulates the formation of medullary bone, which provides available calcium for eggshell formation. The bone loss of laying hens is caused by the continuous dynamic changes of structure bone leading to bone fragility and susceptibility. The degree of medullary bone mineralization in sexual maturity is positively correlated with bone quality in the late laying stage. This study aimed to explore the molecular regulation mechanism of bone metabolism pre- and postsexual maturity in hens based on the joint analysis of transcriptome and metabolome...
February 15, 2024: Poultry Science
https://read.qxmd.com/read/38414417/the-protective-effect-of-l-theanine-on-the-intestinal-barrier-in-heat-stressed-organisms
#6
JOURNAL ARTICLE
Bin Wang, Sha Liu, Ling Lin, Wei Xu, Zhihua Gong, Wenjun Xiao
Heat stress caused by heatwaves, extreme temperatures, and other weather can damage the intestinal barrier of organisms. L-Theanine (LTA) attenuates heat stress-induced oxidative stress, inflammatory responses, and impaired immune function, but its protective effect on the intestinal barrier of heat-stressed organisms is unclear. In this study, low (100 mg kg-1 d-1 ), medium (200 mg kg-1 d-1 ), and high (400 mg kg-1 d-1 ) dosages of LTA were used in the gavage of C57BL/6J male mice that were experimented on for 50 d...
February 28, 2024: Food & Function
https://read.qxmd.com/read/38412820/root-microbiota-connecting-nitrogen-metabolism-and-theanine-synthesis-in-tea-plants
#7
JOURNAL ARTICLE
Jingying Zhang, Haoran Xu, Yang Bai
Tea varieties exhibit seasonal theanine accumulation, with the high-theanine tea variety Rougui having a diverse root microbiota rich in nitrogen-related microbes. A synthetic community derived from Rougui roots enhances tea growth and theanine synthesis under nitrogen deficiency, emphasizing the microbiota's pivotal role.
February 26, 2024: Current Biology: CB
https://read.qxmd.com/read/38409501/development-of-a-sers-aptasensor-for-the-determination-of-l-theanine-using-a-noble-metal-nanoparticle-magnetic-nanospheres-composite
#8
JOURNAL ARTICLE
Wei Zhang, De Zhang, Pu Wang, Xiaoming Li, Zhetao Wang, Qiang Chen, Jie Huang, Zhi Yu, Fei Guo, Pei Liang
An ultrasensitive surface-enhanced Raman spectroscopy (SERS) aptamer sensor (aptasensor) using a noble metal nanoparticle-magnetic nanospheres composite was developed for L-theanine detection. It makes use of Fe3 O4 @Au MNPs and Au@Ag NPs embedded with the Raman reporter 4-mercaptobenzoic acid (4MBA). Au@4MBA@Ag NPs modified by aptamer and Fe3 O4 @Au MNPs modified by cDNA created the aptasensor with the strongest Raman signal of 4MBA through the specific binding of the aptamer. With the preferred binding of L-theanine aptamer to L-theanine, Au@4MBA@Ag NPs were released from Fe3 O4 @Au MNPs, causing a linear decrease in SERS intensity to achieve the SERS detection of the L-theanine...
February 27, 2024: Mikrochimica Acta
https://read.qxmd.com/read/38391461/l-theanine-improves-the-gelation-of-ginkgo-seed-proteins-at-different-ph-levels
#9
JOURNAL ARTICLE
Luyan Zhang, Huifang Ge, Jing Zhao, Changqi Liu, Yaosong Wang
L-theanine (L-Th), a non-protein amino acid naturally found in teas and certain plant leaves, has garnered considerable attention due to its health benefits and potential to modify proteins such as ginkgo seed proteins, which have poor gelling properties, thereby expanding their applications in the food industry. The objective of this study was to investigate the impact of varying concentrations of L-Th (0.0%, 0.5%, 1.0%, and 2.0%) on the gelling properties of ginkgo seed protein isolate (GSPI) at various pH levels (5...
February 6, 2024: Gels
https://read.qxmd.com/read/38366595/root-microbiota-of-tea-plants-regulate-nitrogen-homeostasis-and-theanine-synthesis-to-influence-tea-quality
#10
JOURNAL ARTICLE
Wei Xin, Jianming Zhang, Yongdong Yu, Yunhe Tian, Hao Li, Xiaolu Chen, Wei Li, Yanlin Liu, Ting Lu, Biyun He, Yan Xiong, Zhenbiao Yang, Tongda Xu, Wenxin Tang
The flavor profile of tea is influenced not only by different tea varieties but also by the surrounding soil environment. Recent studies have indicated the regulatory role of soil microbes residing in plant roots in nutrient uptake and metabolism. However, the impact of this regulatory mechanism on tea quality remains unclear. In this study, we showed that a consortium of microbes isolated from tea roots enhanced ammonia uptake and facilitated the synthesis of theanine, a key determinant of tea taste. Variations were observed in the composition of microbial populations colonizing tea roots and the rhizosphere across different seasons and tea varieties...
February 2, 2024: Current Biology: CB
https://read.qxmd.com/read/38357888/dynamic-dna-methylation-regulates-season-dependent-secondary-metabolism-in-the-new-shoots-of-tea-plants
#11
JOURNAL ARTICLE
Mengxue Han, Shijia Lin, Biying Zhu, Wei Tong, Enhua Xia, Yuanrong Wang, Tianyuan Yang, Shupei Zhang, Xiaochun Wan, Jianjun Liu, Qingfeng Niu, Jianhua Zhu, Shilai Bao, Zhaoliang Zhang
Plant secondary metabolites are critical quality-conferring compositions of plant-derived beverages, medicines, and industrial materials. The accumulations of secondary metabolites are highly variable among seasons; however, the underlying regulatory mechanism remains unclear, especially in epigenetic regulation. Here, we used tea plants to explore an important epigenetic mark DNA methylation (5mC)-mediated regulation of plant secondary metabolism in different seasons. Multiple omics analyses were performed on spring and summer new shoots...
February 15, 2024: Journal of Agricultural and Food Chemistry
https://read.qxmd.com/read/38357378/the-effects-of-tea-plant-age-on-the-color-taste-and-chemical-characteristics-of-yunnan-congou-black-tea-by-multi-spectral-omics-insight
#12
JOURNAL ARTICLE
Piaopiao Long, Shengxiao Su, Zisheng Han, Daniel Granato, Wei Hu, Jiaping Ke, Liang Zhang
The present study comprehensively used integrated multi-spectral omics combined with sensory evaluation analysis to investigate the quality of three types of Yunnan Congou black teas from different tree ages (decades, DB; hundreds, HB; a thousand years, TB). TB infusion presented the highest scores of sweetness and umami, higher brightness, and yellow hue. Eighty-four marker metabolites were identified, including Amadori rearrangement products, catechin oxidation products, flavonoid glycosides, and organic acids, which are simultaneously related to tea infusions' color and taste...
March 30, 2024: Food chemistry: X
https://read.qxmd.com/read/38337959/multi-omics-research-accelerates-the-clarification-of-the-formation-mechanism-and-the-influence-of-leaf-color-variation-in-tea-camellia-sinensis-plants
#13
REVIEW
Yan-Gen Fan, Ting-Ting Zhao, Qin-Zeng Xiang, Xiao-Yang Han, Shu-Sen Yang, Li-Xia Zhang, Li-Jun Ren
Tea is a popular beverage with characteristic functional and flavor qualities, known to be rich in bioactive metabolites such as tea polyphenols and theanine. Recently, tea varieties with variations in leaf color have been widely used in agriculture production due to their potential advantages in terms of tea quality. Numerous studies have used genome, transcriptome, metabolome, proteome, and lipidome methods to uncover the causes of leaf color variations and investigate their impacts on the accumulation of crucial bioactive metabolites in tea plants...
January 31, 2024: Plants (Basel, Switzerland)
https://read.qxmd.com/read/38324412/novel-flavonol-alkaloids-in-green-tea-synthesis-detection-and-anti-alzheimer-s-disease-effect-in-a-transgenic-caenorhabditis-elegans-cl4176-model
#14
JOURNAL ARTICLE
Chen-Hui Chen, Yi Yang, Jia-Ping Ke, Zi Yang, Jia-Yi Li, Yu-Xing Zhang, Guangjin Liu, Zhijun Liu, Guangmin Yao, Guan-Hu Bao
Novel N -ethy-2-pyrrolidinone-substituted flavonols, myricetin alkaloids A-C ( 1 - 3 ), quercetin alkaloids A-C ( 4a , 4b , and 5 ), and kaempferol alkaloids A and B ( 6 and 7 ), were prepared from thermal reaction products of myricetin, quercetin, kaempferol─l-theanine, respectively. We used HPLC-ESI-HRMS/MS to detect 1 - 7 in 14 cultivars of green tea and found that they were all present in "Shuchazao," "Longjing 43", "Fudingdabai", and "Zhongcha 108" green teas. The structures of 1 - 4 and 6 were determined by extensive 1D and 2D NMR spectroscopies...
February 7, 2024: Journal of Agricultural and Food Chemistry
https://read.qxmd.com/read/38304331/comprehensive-dissection-of-variation-and-accumulation-of-free-amino-acids-in-tea-accessions
#15
JOURNAL ARTICLE
Rong Huang, Zhihua Wang, Weiwei Wen, Mingzhe Yao, Haoran Liu, Fang Li, Shuran Zhang, Dejiang Ni, Liang Chen
Free amino acids (FAAs) positively determine the tea quality, notably theanine (Thea), endowing umami taste of tea infusion, which is the profoundly prevalent research in albino tea genetic resources. Therefore, 339 tea accessions were collected to study FAAs level for deciphering its variation and accumulation mechanism. Interestingly, alanine (Ala) and Thea which had the highest diversity index ( H' ) value among three varieties of Camellia sinensis (L.) O. Kuntze were significantly higher than wild relatives ( P  < 0...
January 2024: Horticulture Research
https://read.qxmd.com/read/38302031/mechanism-of-interaction-between-l-theanine-and-maize-starch-in-ultrasonic-field-based-on-dft-calculations-rheological-properties-multi-scale-structure-and-in-vitro-digestibility
#16
JOURNAL ARTICLE
Zongwei Hao, Ailong Hu, Juntao Cheng, Zhenni Ma, Zhaofeng Li, Jiali Lv, Huajian Xu, Huifang Ge, Hongyan Wang, Zhenyu Yu, Zhongwen Xie, Yiqun Du
The digestibility of starch-based foods is receiving increased attention. To date, the full understanding of how including L-theanine (THE) can modify the structural and digestive properties of starch has not been fully achieved. Here, we investigated the multi-scale structure and digestibility of maize starch (MS) regulated by THE in ultrasound field and the molecular interactions. Ultrasound disrupted the structure of starch granules and opened the molecular chains of starch, promoting increased THE binding and producing more low-order or disordered crystal structures...
January 30, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38292681/metabolomics-investigation-of-the-chemical-variations-in-white-teas-with-different-producing-areas-and-storage-durations
#17
JOURNAL ARTICLE
Zewen Chen, Weidong Dai, Mengfan Xiong, Jianjian Gao, Hongjie Zhou, Dan Chen, Yali Li
In this study, we employed nontargeted metabolomics and quantitative analysis to explore the variations in metabolites among white teas from different production areas and with varying storage durations. A total of 83 compounds exhibited differential levels between Zhenghe and Fuding white tea, 89 between Zhenghe and Jinggu, and 75 between Fuding and Jinggu white tea. Concerning the storage of white tea, the concentrations of flavanols, dimeric catechins, and amino acids decreased over time, while N -ethyl-2-pyrrolidone-substituted flavanols (EPSFs), caffeine, adenosine monophosphate (AMP), and adenosine increased...
March 30, 2024: Food chemistry: X
https://read.qxmd.com/read/38281712/c-ebp%C3%AE-aggravates-renal-fibrosis-in-ckd-through-the-nox4-ros-apoptosis-pathway-in-tubular-epithelial-cells
#18
JOURNAL ARTICLE
Ziru Xia, Zhaonan Wei, Xin Li, Yunzi Liu, Xiangchen Gu, Siyi Huang, Xiaoyue Zhang, Weiming Wang
BACKGROUND: Chronic kidney disease (CKD) is a prevalent renal disorder with various risk factors. Emerging evidence indicates that the transcriptional factor CCAAT/enhancer binding protein alpha (C/EBPα) may be associated with renal fibrosis. However, the precise role of C/EBPα in CKD progression remains unexplored. METHODS: We investigated the involvement of C/EBPα in CKD using two distinct mouse models induced by folic acid (FA) and unilateral ureteral obstruction (UUO)...
January 26, 2024: Biochimica et Biophysica Acta. Molecular Basis of Disease
https://read.qxmd.com/read/38277867/enhanced-theanine-production-with-reduced-atp-supply-by-alginate-entrapped-escherichia-coli-co-expressing-%C3%AE-glutamylmethylamide-synthetase-and-polyphosphate-kinase
#19
JOURNAL ARTICLE
Do Hyun Cho, Suwon Kim, Yeda Lee, Yuni Shin, Suhye Choi, Jinok Oh, Hee Taek Kim, See-Hyoung Park, Kyungmoon Park, Shashi Kant Bhatia, Yung-Hun Yang
L-theanine is an amino acid with a unique flavor and many therapeutic effects. Its enzymatic synthesis has been actively studied and γ-Glutamylmethylamide synthetase (GMAS) is one of the promising enzymes in the biological synthesis of theanine. However, the theanine biosynthetic pathway with GMAS is highly ATP-dependent and the supply of external ATP was needed to achieve high concentration of theanine production. As a result, this study aimed to investigate polyphosphate kinase 2 (PPK2) as ATP regeneration system with hexametaphosphate...
January 15, 2024: Enzyme and Microbial Technology
https://read.qxmd.com/read/38276780/recent-advances-in-the-specialized-metabolites-mediating-resistance-to-insect-pests-and-pathogens-in-tea-plants-camellia-sinensis
#20
REVIEW
Jin Zhang, Yongchen Yu, Xiaona Qian, Xin Zhang, Xiwang Li, Xiaoling Sun
Tea is the second most popular nonalcoholic beverage consumed in the world, made from the buds and young leaves of the tea plants ( Camellia sinensis ). Tea trees, perennial evergreen plants, contain abundant specialized metabolites and suffer from severe herbivore and pathogen attacks in nature. Thus, there has been considerable attention focusing on investigating the precise function of specialized metabolites in plant resistance against pests and diseases. In this review, firstly, the responses of specialized metabolites (including phytohormones, volatile compounds, flavonoids, caffeine, and L-theanine) to different attacks by pests and pathogens were compared...
January 22, 2024: Plants (Basel, Switzerland)
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