keyword
https://read.qxmd.com/read/36483519/microscopic-corneal-epithelial-changes-and-clinical-outcomes-in-simple-limbal-epithelial-transplantation-surgery-after-treatment-with-amniotic-membrane-eye-drops-amed-a-case-report
#21
Erika Bonacci, Raphael Kilian, Clara Rizzo, Alessandra De Gregorio, Francesca Bosello, Adriano Fasolo, Diego Ponzin, Giorgio Marchini, Emilio Pedrotti
PURPOSE: To describe the microscopic epithelial changes and the clinical outcomes of a patient treated with amniotic membrane eye drops (AMED) because of a persistent epithelial defect (PED) and a partial limbal stem cell deficiency (LSCD) after simple limbal epithelial transplantation (SLET) and deep anterior lamellar keratoplasty (DALK). OBSERVATIONS: A 72-year-old patient, who had previously undergone SLET and DALK due to a total LSCD, presented with a PED related to a partial LSCD, and was treated with AMED for one month...
March 2023: American Journal of Ophthalmology Case Reports
https://read.qxmd.com/read/36453361/modified-supportive-simple-limbal-epithelial-transplantation-m-slet-a-surgical-technique-modified-for-limbal-stem-cell-deficiency
#22
JOURNAL ARTICLE
Sameer G Datar, Gayatri N Godse
This study aimed to develop and modify the surgical technique of simple limbal epithelial transplantation in patients with limbal stem cell deficiency to provide support to epithelial explants during the post-operative period. This is a case series of five eyes of five patients who underwent modified supportive simple limbal epithelial transplantation (M-SLET) surgery. The health and stability of the ocular surface were assessed based on clinical slit lamp examination; they were the main outcome measures. All patients had a stable ocular surface and healed epithelium during all the follow-up visits...
December 2022: Indian Journal of Ophthalmology
https://read.qxmd.com/read/35918016/update-on-pediatric-corneal-diseases-and-keratoplasty
#23
REVIEW
Murugesan Vanathi, Nimmy Raj, Rakhi Kusumesh, Neelima Aron, Noopur Gupta, Radhika Tandon
Managing pediatric corneal disorders is challenging as the prognosis of pediatric keratoplasty depends on several factors. Advancements in the genetic basis of congenital corneal diseases and investigations in congenital corneal conditions provide a better understanding of pediatric corneal conditions. Surgeons performing keratoplasty in children now have a choice of various techniques. Evolving surgical techniques of anterior lamellar and endothelial keratoplasties have expanded the management interventions in these pediatric corneal morbidity conditions; however, considerable concerns still exist in association with corneal transplantation in infants and children...
2022: Survey of Ophthalmology
https://read.qxmd.com/read/35816015/long-term-comprehensive-management-of-bilateral-limbal-stem-cell-deficiency-secondary-to-severe-chemical-burn-10-years-of-follow-up
#24
JOURNAL ARTICLE
Piero Carletti, Paula A Sepulveda Beltran, Harry Levine, Sander R Dubovy, Victor L Perez, Guillermo Amescua
PURPOSE: To describe the long-term management of bilateral limbal stem cell deficiency secondary to a severe chemical burn. METHODS: Descriptive case report. IMPORTANCE: This case highlights the importance of early intervention in ocular chemical burns for the preservation of tissue integrity and avoidance of perforation. We also review the use of proper ocular surface reconstructive techniques to restore the function of the limbal area, as well as the immunomodulatory strategies and follow-up needed for these interventions...
July 11, 2022: Ocular Immunology and Inflammation
https://read.qxmd.com/read/35692544/a-review-of-the-diagnosis-and-treatment-of-limbal-stem-cell-deficiency
#25
REVIEW
Anahita Kate, Sayan Basu
Limbal stem cell deficiency (LSCD) can cause significant corneal vascularization and scarring and often results in serious visual morbidity. An early and accurate diagnosis can help prevent the same with a timely and appropriate intervention. This review aims to provide an understanding of the different diagnostic tools and presents an algorithmic approach to the management based on a comprehensive clinical examination. Although the diagnosis of LSCD usually relies on the clinical findings, they can be subjective and non-specific...
2022: Frontiers in Medicine
https://read.qxmd.com/read/35564002/risk-benefit-assessment-of-an-increase-in-the-iodine-fortification-level-of-foods-in-denmark-a-pilot-study
#26
JOURNAL ARTICLE
Lea Sletting Jakobsen, Josefine Ostenfeld Nielsen, Sophie Egesø Paulsen, Malene Outzen, Allan Linneberg, Line Tang Møllehave, Tue Christensen, Gitte Ravn-Haren
Iodine deficiency is one of the most common nutritional disorders worldwide. In Denmark, the mandatory iodine fortification of salt of 13 ppm was introduced in 2000 to eradicate mild to moderate iodine deficiency and the fortification level was increased to 20 ppm in 2019. However, the optimal iodine intake is a narrow interval, and the risk of disease increases with intakes both below and above this interval. In this study, we quantified the risk-benefit balance in the Danish adult population by increasing the mandatory fortification level...
April 28, 2022: Foods (Basel, Switzerland)
https://read.qxmd.com/read/35427890/allogeneic-simple-limbal-epithelial-transplantation-for-bilateral-limbal-stem-cell-deficiency-in-chronic-vernal-keratoconjunctivitis-a-case-report
#27
JOURNAL ARTICLE
Neha Jain, Anahita Kate, Simmy Chaudhary, Sayan Basu
INTRODUCTION AND IMPORTANCE: This report describes the management of bilateral limbal stem cell deficiency (LSCD) in vernal keratoconjunctivitis (VKC) with allogeneic simple limbal epithelial transplantation (allo-SLET). PRESENTATION OF CASE: A 22-year-old female presented with bilateral VKC with total LSCD. A thick fibrotic pannus was present in both eyes, with visual axis involvement in the right eye. The central cornea in the left eye was clear. The patient underwent a cadaveric allo-SLET in the right eye to restore the ocular surface...
May 2022: International Journal of Surgery Case Reports
https://read.qxmd.com/read/35063298/surgical-approaches-to-autologous-limbal-stem-cell-transplantation-lsct-following-severe-corneal-chemical-burns
#28
REVIEW
S Mohanna, S Elahi, C Panthier, D Gatinel
Chemical injury of the conjunctiva and cornea are true ocular emergencies and require immediate intervention. They can produce severe, extensive ocular damage, including limbal stem cell deficiency (LSCD), and lead to irreversible visual loss. LSCD can be treated surgically through autologous limbal stem cell transplantation (LSCT). Autologous LSCT can be performed through cultivated limbal epithelial transplantation (CLET) or by direct grafting of limbal epithelial cells through conjunctival-limbal autografting (CLAU) or simple limbal epithelial transplantation (SLET)...
March 2022: Journal Français D'ophtalmologie
https://read.qxmd.com/read/35006734/tuning-electrospun-substrate-stiffness-for-the-fabrication-of-a-biomimetic-amniotic-membrane-substitute-for-corneal-healing
#29
JOURNAL ARTICLE
Thomas E Paterson, Hala S Dhowre, Danilo Villanueva, Joseph W Holland, Abhinav Reddy Kethiri, Vivek Singh, Frederik Claeyssens, Sheila MacNeil, Ilida Ortega Asencio
Corneal blindness is the fourth most common cause of vision impairment worldwide with a high incidence in global south countries. A recently developed surgical technique for treating corneal blindness is simple limbal epithelial transplantation (SLET), which uses small pieces of healthy limbal tissue (limbal explants) delivered to the damaged eye using the human amniotic membrane (AM) as a carrier. SLET relies on the use of tissue banks for the AM that reduces the availability of the technique. Replacing the AM with a synthetic membrane is key to making SLET more accessible to those who need it...
July 19, 2021: ACS Applied Bio Materials
https://read.qxmd.com/read/34873514/amniotic-membrane-granuloma-in-a-case-of-ocular-chemical-injury-clinical-features-histopathology-and-outcomes
#30
Anahita Kate, Sayan Basu
This report describes the clinical features of a granuloma within the layers of amniotic membranes (AM) along with its surgical management and outcome. An eight-year-old boy underwent an AM graft in the right eye for an acute chemical injury. As there was slow healing of the ocular surface, the eye was subjected to a simple limbal epithelial transplantation (SLET). Although the corneal surface was well epithelialized, a superior symblepharon was noted six weeks following SLET. Excision of the fibrotic tissue with an AM graft was carried out...
October 2021: Curēus
https://read.qxmd.com/read/34785885/surgical-management-of-unilateral-partial-limbal-stem-cell-deficiency-conjunctival-autografts-versus-simple-limbal-epithelial-transplantation
#31
JOURNAL ARTICLE
Swapna S Shanbhag, Sanjay Chanda, Pragnya R Donthineni, Sayan Basu
PURPOSE: To evaluate the clinical outcomes of conjunctival autograft (CAG) versus simple limbal epithelial transplant (SLET) for management of unilateral partial limbal stem cell deficiency (LSCD). METHODS: This retrospective, comparative, interventional case series evaluated 30 eyes of 30 patients with unilateral partial LSCD. After corneal pannus dissection, 17 patients underwent CAG where graft was harvested from the ipsilateral or contralateral eye, while 13 patients underwent SLET where limbal biopsy was harvested from the contralateral eye...
2021: Clinical Ophthalmology
https://read.qxmd.com/read/34782530/outcomes-of-surgical-interventions-for-the-treatment-of-limbal-stem-cell-deficiency
#32
REVIEW
Anita Ganger, Archita Singh, M Kalaivani, Noopur Gupta, Murugesan Vanathi, Sujata Mohanty, Radhika Tandon
Background & objectives: In the current scenario, with availability of different surgical procedures for limbal stem cell deficiency (LSCD), there exists no common consensus as to the standardization of the management protocol for the same. In addition, there also exists diversity in the views about the clinical diagnosis, ancillary investigations and clinical parameters. The objective of the present study was to evaluate the reported outcomes of surgical interventions for the management of LSCD...
July 2021: Indian Journal of Medical Research
https://read.qxmd.com/read/34605742/longitudinal-changes-in-corneal-epithelial-thickness-and-reflectivity-following-simple-limbal-epithelial-transplantation-an-optical-coherence-tomography-based-study
#33
JOURNAL ARTICLE
Anahita Kate, Tanvi Mudgil, Sayan Basu
PURPOSE: To describe the changes in corneal epithelial thickness and reflectivity following simple limbal epithelial transplantation (SLET) using anterior segment optical coherence tomography (ASOCT). METHODS: This was a prospective imaging study of 31 eyes of 29 patients who had undergone autologous or allogeneic SLET for limbal stem cell deficiency and had stable, avascular surfaces postoperatively. ASOCT scans of all four quadrants were taken preoperatively and at 1-week, 1-month, 3-month, 6-month, and 1-year postoperative time points in the eyes undergoing SLET...
March 2022: Current Eye Research
https://read.qxmd.com/read/34481416/author-s-response-to-letter-outcomes-of-ipsilateral-simple-limbal-epithelial-transplant-slet-mitomycin-tenonectomy-and-amniotic-membrane-transplantation-for-treatment-of-recurrent-pterygium
#34
LETTER
Tanya Trinh, Michael Mimouni, Zale Mednick, Adi Einan-Lifshitz, Eyal Cohen, Gisella Santaella, Nir Sorkin, Allan Slomovic
No abstract text is available yet for this article.
October 1, 2021: Cornea
https://read.qxmd.com/read/34440077/stem-cells-in-the-path-of-light-from-corneal-to-retinal-reconstruction
#35
REVIEW
Ovidiu Samoila, Lacramioara Samoila
The future of eye reconstruction invariably includes stem cells transplantation. Corneal limbus, corneal stroma, trabeculum, retinal cells, optic nerve, and all structures that are irreversibly damaged and have no means to be repaired or replaced, through conventional treatment or surgery, represent targets for stem cell reconstruction. This review tries to answer the question if there is any clinical validation for stem therapies, so far, starting from the cornea and, on the path of light, arriving to the retina...
July 23, 2021: Biomedicines
https://read.qxmd.com/read/34381920/visual-rehabilitation-with-limbal-autologous-stem-cells-transplant-and-cataract-surgery-in-a-patient-with-ocular-surface-squamous-neoplasia
#36
Eduardo J Polania-Baron, Enrique O Graue-Hernandez, Arturo Ramirez-Miranda, Guillermo Amescua, Alejandro Navas
PURPOSE: To describe the outcome of simple limbal epithelial transplantation along with Phacoemulsification and IOL implantation for visual rehabilitation in limbal stem cell deficiency due to ocular surface squamous neoplasia. OBSERVATIONS: This case report of a 66-year-old woman clinically diagnosed with OSSN in her right eye involving all cornea and limbus meridians. Topical chemotherapy for tumor treatment was done, followed by SLET and sequential cataract surgery...
September 2021: American Journal of Ophthalmology Case Reports
https://read.qxmd.com/read/34352364/preliminary-experience-rationale-of-primary-allo-simple-limbal-epithelial-transplantation-slet-following-surgical-excision-of-ocular-surface-tumors
#37
JOURNAL ARTICLE
Geetha Iyer, Bhaskar Srinivasan, Richa Dhiman, Manokamna Agarwal, Rama Rajagopal
AIM: To report the preliminary outcomes and elucidate the possible rationale of alloSLET for primary ocular surface reconstruction following excision of extensive ocular surface tumors. METHODS: Retrospective interventional case series with a minimum postoperative follow up of 1 year. AlloSLET was performed along with wide surgical excision and cryotherapy in 3 eyes. RESULTS: Of the 2 eyes with extensive OSSN and one with an extensive pigmented lesion, there was no occurrence of symblepharon in all 3 eyes...
October 2021: Ocular Surface
https://read.qxmd.com/read/34321388/application-of-right-bronchial-occlusion-under-artificial-pneumothorax-in-the-thoracic-phase-of-minimally-invasive-mckeown-esophagectomy
#38
JOURNAL ARTICLE
Li Li, Luo Zhao, Jia He, Zhijun Han
PURPOSE: To evaluate the feasibility and safety of single-lumen endotracheal intubation combined with right bronchial occlusion (SLET) under artificial pneumothorax in minimally invasive McKeown esophagectomy. METHODS: A total of 165 patients who underwent minimally invasive McKeown esophagectomy at Peking Union Medical College Hospital were retrospectively analyzed. In all, 48 patients received double-lumen endotracheal intubation (DLET group), and 117 patients received SLET-B (SLET-B group)...
July 28, 2021: Annals of Thoracic and Cardiovascular Surgery
https://read.qxmd.com/read/34307433/approaches-for-health-effect-characterization-in-risk-benefit-assessment-of-foods-a-comparative-case-study
#39
JOURNAL ARTICLE
Sofie Theresa Thomsen, Maarten Nauta, Lea Sletting Jakobsen, Marianne Uhre Jakobsen, Heddie Mejborn, Malene Outzen, Morten Poulsen, Gitte Ravn-Haren, Rikke Andersen
One of the challenges in quantitative risk-benefit assessment (RBA) of foods is the choice of approach for health effect characterization to estimate the health impact of dietary changes. The purpose of health effect characterization is to describe an association between intake of a food or food component and a health effect in terms of a dose-response relationship. We assessed the impact of the choice of approach for health effect characterization in RBA in two case studies based on substitution of (i) white rice by brown rice and (ii) unprocessed red meat by vegetables...
2021: Frontiers in Nutrition
https://read.qxmd.com/read/34304214/innovative-technique-of-mini-simple-limbal-epithelial-transplantation-in-pediatric-patients
#40
JOURNAL ARTICLE
Anju Pannu, Alok Sati, Sanjay Kumar Mishra, Sonali Kumar, Sanjay Dhar
In this article, we introduce a modified technique of minor ipsilateral simple limbal epithelial transplantation (mini-SLET) in pediatric patients of limbal stem cell deficiency (LSCD). Two children with unilateral partial LSCD underwent the innovative technique of mini-SLET, where harvested limbal tissues were placed over the raw cornea and were covered with amniotic membrane. Both patients were followed till 9 months. Both cases showed favorable outcome and uneventful recovery. Results were comparable with the classical technique...
August 2021: Indian Journal of Ophthalmology
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