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https://www.readbyqxmd.com/read/29777682/inhibition-of-bet-bromodomains-restores-corticosteroid-responsiveness-in-a-mixed-granulocytic-mouse-model-of-asthma
#1
Ahmed Nadeem, Sheikh F Ahmad, Naif O Al-Harbi, Nahid Siddiqui, Khalid E Ibrahim, Sabry M Attia
Asthma is a heterogeneous disease characterized by different endotypes/phenotypes. Th2/Th17 driven mixed granulocytic asthma is one of them and shows resistance to corticosteroid therapy. Bromodomain and extra-terminal (BET) proteins are required for differentiation of Th17 cells which play a pivotal role in neutrophilic inflammation. Therefore, we sought to characterize the differential effects of BET inhibitor versus corticosteroids, and their potential synergism in cockroach allergen extract (CE)-induced mixed granulocytic (eosinophilic and neutrophilic) mouse model of asthma having Th2/Th17 endotype...
May 16, 2018: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29771232/methicillin-resistant-staphylococcus-argenteus-misidentified-as-methicillin-resistant-staphylococcus-aureus-emerging-in-western-sweden
#2
Erika Tång Hallbäck, Nahid Karami, Ingegerd Adlerberth, Sofia Cardew, Maria Ohlén, Hedvig Engström Jakobsson, Liselott Svensson Stadler
Two strains included in a whole-genome sequencing project for methicillin-resistant Staphylococcus aureus (MRSA) were identified as non-Staphylococcus aureus when the sequences were analysed using the bioinformatics software ALEX (www.1928diagnostics.com, Gothenburg, Sweden). Sequencing of the sodA gene of these strains identified them as Staphylococcus argenteus. The collection of MRSA in western Sweden was checked for additional strains of this species. A total of 18 strains of S. argenteus isolated between 2011 and December 2017 were identified...
May 17, 2018: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29769549/detection-of-chikungunya-virus-dna-using-two-dimensional-mos-2-nanosheets-based-disposable-biosensor
#3
Chaitali Singhal, Manika Khanuja, Nahid Chaudhary, C S Pundir, Jagriti Narang
Development of platforms for a reliable, rapid, sensitive and selective detection of chikungunya virus (CHIGV) is the need of the hour in developing countries. To the best of our knowledge, there are no reports available for the electrochemical detection of CHIGVDNA. Therefore, we aim at developing a biosensor based on molybdenum disulphide nanosheets (MoS2 NSs) for the point-of-care diagnosis of CHIGV. Briefly, MoS2 NSs were synthesized by chemical route and characterized using scanning electron microscopy, transmission electron microscopy, UV-Vis spectroscopy, Raman spectroscopy and X-Ray Diffraction...
May 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29766814/effect-of-%C3%AE-d-mannuronic-acid-m2000-on-oxidative-stress-enzymes-gene-using-healthy-donor-peripheral-blood-mononuclear-cells-for-evaluating-the-anti-aging-property
#4
Mahsa Taeb, Abdollah Jafarzadeh, Seyed Shahabeddin Mortazavi-Jahromi, Nahid Zainodini, Mohammad Reza Mirzaei, Fahimeh Jafarnezhad-Ansariha, Zahra Aghazadeh, Abbas Mirshafiey
OBJECTIVE: This research aimed to study the anti-aging and anti-inflammatory effects of low and high doses of the β-D-mannuronic (M2000) on gene expression of enzymes involved in oxidative stress (including SOD2, GST, GPX1, CAT, iNOS, and MPO) in peripheral blood mononuclear cells (PBMCs) of healthy donors under in vitro conditions. METHODS: The PBMCs were separated and the RNAs were then extracted and the cDNAs synthesized, and expression levels of the mentioned genes were detected by qRT-PCR...
May 15, 2018: Current Drug Discovery Technologies
https://www.readbyqxmd.com/read/29762475/growth-hormone-secretion-patterns-in-german-landrace-dl-fetuses-and-piglets-compared-to-dl-piglets-with-inherited-1-25-dihydroxyvitamin-d3-deficiency
#5
Manfred Mielenz, Michael W Pfaffl, Christina Schlumbohm, Johein Harmeyer, Nahid Parvizi
The regulation of growth hormone (GH) release during prenatal development and during early postnatal life is not entirely clarified. In this study plasma GH concentrations in pigs with inherited pseudo vitamin D deficiency type I (PDDR-I), which regularly show growth retardation, were compared during ontogeny with unaffected pigs of the same breed (German Landrace, DL) as control. Plasma GH concentrations were measured in plasma of chronically catheterized fetuses (beginning on day 101 after mating or after artificial insemination) and in piglets (day 37 postpartum (p...
May 15, 2018: Nutrients
https://www.readbyqxmd.com/read/29761318/association-of-sugar-sweetened-beverages-consumption-with-non-alcoholic-fatty-liver-disease-a-systematic-review-and-meta-analysis
#6
REVIEW
Farzaneh Asgari-Taee, Nahid Zerafati-Shoae, Mohsen Dehghani, Masoumeh Sadeghi, Hamid R Baradaran, Shima Jazayeri
PURPOSE: The relationship between consumption of sugar sweetened beverages (SSB) and NAFLD has been reported in several epidemiological studies, but the results are inconsistent. The present systematic review and meta-analysis of observational studies was carried out to assess the relationship between sugar sweetened beverages consumption and NAFLD. METHODS: Online databases were searched systematically through December, 2016 for studies investigating association between SSB consumption and NAFLD but limited to observational studies in human...
May 14, 2018: European Journal of Nutrition
https://www.readbyqxmd.com/read/29757971/comparison-of-the-conventional-and-electroenhanced-direct-immersion-solid-phase-microextraction-for-sampling-of-nicotine-in-biological-fluids-of-the-human-body
#7
Sana Abdolhosseini, Ali Reza Ghiasvand, Nahid Heidari
A stainless steel fiber was made porous and adhesive by platinization and then coated by nanostructured polypyrrole (PPy), using an appropriate electrophoretic deposition (EPD) method. The morphological surface structure and functional groups of the PPy-coated fiber were studied using SEM (Scanning electron microscope) instrument. The prepared fiber was used for comparison of direct immersion (DI) and electroenhanced direct immersion solid-phase microextraction (EE-DI-SPME) of nicotine in human plasma and urine samples followed by gas chromatography flame ionization detector (GC-FID) determination...
May 14, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29749276/cryopreservation-of-low-number-of-human-spermatozoa-which-is-better-vapor-phase-or-direct-submerging-in-liquid-nitrogen
#8
Akram Hosseini, Mohammad Ali Khalili, Ali Reza Talebi, Azam Agha-Rahimi, Saeed Ghasemi-Esmailabad, Bryan Woodward, Nahid Yari
Cryopreservation and subsequent survival of semen samples with low numbers of human spermatozoa in assisted reproductive technology (ART) facilities can be challenging. The aim of this study was to compare the quality of warmed human spermatozoa following vitrification using direct submerging (DS) in liquid nitrogen (LN2 ) or with LN2 vapour (V). Normozoospermic ejaculates were prepared by the swim-up technique and the motile sperm fraction was divided into three groups: (i) fresh (control); (ii) DS methods in LN2 (DS Group); or (iii) cryopreserved in V (Group V)...
May 11, 2018: Human Fertility: Journal of the British Fertility Society
https://www.readbyqxmd.com/read/29747751/the-effect-of-ginger-supplementation-on-lipid-profile-a-systematic-review-and-meta-analysis-of-clinical-trials
#9
REVIEW
Makan Pourmasoumi, Amir Hadi, Nahid Rafie, Ameneh Najafgholizadeh, Hamed Mohammadi, Mohammad Hossein Rouhani
BACKGROUND: Elevated levels of blood lipids are a major cause of atherosclerosis and consequently cardiovascular disease. Several studies used ginger as a lipid lowering agent. PURPOSE: The aim of the present systematic review and meta-analysis was to clarify the effect of ginger supplementation on lipid parameters. METHODS: PubMed, Scopus, Science Direct, ISI Web of Science and Google Scholar were systematically searched until May 2017 to find clinical trials which examined effect of ginger supplementation on level of lipid parameters in adult participants...
April 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29746282/comparing-the-effects-of-atorvastatin-with-sodium-valproate-divalproex-on-frequency-and-intensity-of-frequent-migraine-headaches-a-double-blind-randomized-controlled-study
#10
Omid Hesami, Mohammad Sistanizad, Elnaz Asadollahzade, Mohammad-Sadegh Johari, Nahid Beladi-Moghadam, Homa Mazhabdar-Ghashghai
OBJECTIVES: To evaluate the prophylactic effects of atorvastatin on frequency, intensity, and duration of migraine attacks compared with sodium valproate. METHODS: In this randomized, double-blind, single-center controlled trial, patients with 6 to 15 migraine attacks per month, which were candidates of preventive treatment, were recruited. The patients were randomly allocated into 2 groups. The first group (A) received atorvastatin 40 mg daily, and the second group (B) received sodium valproate 500 mg daily...
May 2018: Clinical Neuropharmacology
https://www.readbyqxmd.com/read/29746001/evaluation-of-antioxidant-properties-phenolic-compounds-anthelmintic-and-cytotoxic-activities-of-various-extracts-isolated-from-nepeta-cadmea-an-endemic-plant-for-turkey
#11
Arzu Kaska, Nahide Deniz, Mehmet Çiçek, Ramazan Mammadov
Nepeta cadmea Boiss. is a species endemic to Turkey that belongs to the Nepeta genus. Several species of this genus are used in folk medicine. This study was designed to investigate the phenolic compounds, antioxidant, anthelmintic, and cytotoxic activities of various extracts (ethanol, methanol, acetone, and water) of N. cadmea. The antioxidant activities of these extracts were analyzed using scavenging methods (DPPH, ABTS, and H2 O2 scavenging activity), the β-carotene/linoleic acid test system, the phosphomolybdenum method, and metal chelating activity...
May 10, 2018: Journal of Food Science
https://www.readbyqxmd.com/read/29725088/author-correction-role-of-hypoxia-in-diffuse-large-b-cell-lymphoma-metabolic-repression-and-selective-translation-of-hk2-facilitates-development-of-dlbcl
#12
Kavita Bhalla, Sausan Jaber, Nanaji Nahid M, Karen Underwood, Afshin Beheshti, Ari Landon, Binny Bhandary, Paul Bastian, Andrew M Evens, John Haley, Brian Polster, Ronald B Gartenhaus
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
May 3, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29723212/from-arterial-stiffness-to-kidney-graft-microvasculature-mortality-and-graft-survival-within-a-cohort-of-220-kidney-transplant-recipients
#13
Lynda Cheddani, Camélia Radulescu, Michel Chaignon, Alexandre Karras, Yann Neuzillet, Jean-Paul Duong, Nahid Tabibzadeh, Emmanuel Letavernier, Michel Delahousse, Jean-Philippe Haymann
BACKGROUND: Aortic stiffness assessed by carotid-femoral pulse wave velocity (CF-PWV) is a predictor of mortality in several populations. However, little is known in kidney transplant recipients. Our objectives were to evaluate the ability of CF-PWV measured 3 months following transplantation to predict mortality, graft loss and its potential links to measured Glomerular Filtration Rate (mGFR) or kidney graft microvasculature parameters. METHODS: The study is based on a monocentric retrospective cohort including 220 adult kidney graft recipients evaluated three months after transplantation...
2018: PloS One
https://www.readbyqxmd.com/read/29720201/creating-a-positive-perception-of-childbirth-experience-systematic-review-and-meta-analysis-of-prenatal-and-intrapartum-interventions
#14
REVIEW
Mahshid Taheri, Amirhossien Takian, Ziba Taghizadeh, Nahid Jafari, Nasrin Sarafraz
BACKGROUND: A negative experience in childbirth is associated with chronic maternal morbidities. The aim of this systematic review and meta-analysis was to identify currently available successful interventions to create a positive perception of childbirth experience which can prevent psychological birth trauma. METHODS: Randomized controlled trials of interventions in pregnancy or labour which aimed to improve childbirth experience versus usual care were identified from 1994 to September 2016...
May 2, 2018: Reproductive Health
https://www.readbyqxmd.com/read/29717690/sociodemographic-and-geographical-inequalities-in-under-and-overnutrition-among-children-and-mothers-in-bangladesh-a-spatial-modelling-approach-to-a-nationally-representative-survey
#15
Mohammad Nahid Mia, M Shafiqur Rahman, Paritosh K Roy
OBJECTIVE: To investigate the sociodemographic and geographical variation in under- and overnutrition prevalence among children and mothers. DESIGN: Data from the 2014 Bangladesh Demographic and Health Survey were analysed. Stunting and wasting for children and BMI<18·5 kg/m2 for mothers were considered as undernutrition; overweight was considered as overnutrition for both children and mothers. We estimated the prevalence and performed simple logistic regression analyses to assess the associations between outcome variables and predictors...
May 2, 2018: Public Health Nutrition
https://www.readbyqxmd.com/read/29715701/application-of-stem-cells-to-infertility-treatment-with-emphasis-on-mesenchymal-stem-cells-and-ovarian-stem-cells
#16
Nahid Lorzadeh, Nastaran Kazemirad
Stem cells are a population of undifferentiated cells that originated from embryonic and fetal stages of development. Stem cells possess the potency to produce cells that ultimately form different tissues and organs. They are considered as potential alternative novel therapeutic agents for patients suffering from infertility due to their unlimited source and high differentiation potency. There are several studies that have shown that different types of stem cells (mesenchymal stem cells, embryonic, endometrial, and ovarian stem cells) can be differentiated into both spermatozoa and oocytes in vitro, proving their potential clinical use in management and cure of infertility issues...
May 1, 2018: American Journal of Perinatology
https://www.readbyqxmd.com/read/29707566/histopathological-breast-cancer-image-classification-by-deep-neural-network-techniques-guided-by-local-clustering
#17
Abdullah-Al Nahid, Mohamad Ali Mehrabi, Yinan Kong
Breast Cancer is a serious threat and one of the largest causes of death of women throughout the world. The identification of cancer largely depends on digital biomedical photography analysis such as histopathological images by doctors and physicians. Analyzing histopathological images is a nontrivial task, and decisions from investigation of these kinds of images always require specialised knowledge. However, Computer Aided Diagnosis (CAD) techniques can help the doctor make more reliable decisions. The state-of-the-art Deep Neural Network (DNN) has been recently introduced for biomedical image analysis...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29699949/risk-factors-of-gestational-diabetes-mellitus-using-results-of-a-prospective-population-based-study-in-iranian-pregnant-women
#18
Ferdos Zaman, Sedigheh Nouhjah, Hajieh Shahbazian, Nahid Shahbazian, Seyed Mahmoud Latifi, Alireza Jahanshahi
AIMS: Early identification of at-risk groups is an important step in preventing gestational diabetes and its subsequent side effects. This study aimed to evaluate the risk factors of gestational diabetes based on the International Association of Diabetes and Pregnancy Study Groups criteria in Ahvaz. MATERIAL AND METHODS: In a cross-sectional case control study, 520 pregnant women involving life after gestational diabetes Ahvaz cohort study (LAGAs) were investigated for risk factors of gestational diabetes mellitus...
April 21, 2018: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/29696053/psychological-signs-as-the-only-presentation-of-wilson-s-disease-in-an-11-year-old-boy
#19
Mehran Beiraghi Toosi, Javad Akhondian, Farah Ashraf Zadeh, Nahid Donyadideh, Asma Javid
Wilson's disease (WD) is a rare autosomal recessive disease due to copper metabolism disturbance. The clinical presentation spectrum of Wilson's disease is wide and initial findings of the disease depend on the organ involved. Neurologic disorders can develop insidiously or precipitously with intention tremor, dysarthria, rigid dystonia, Parkinsonism, deterioration in school performance or behavioral changes. This article is presenting an 11-yr old boy with chief complaint of falling and upper limb spasm. He referred to the Neurology Department, Ghaem Hospital, Mashhad, northeastern Iran in 2016...
2018: Iranian Journal of Child Neurology
https://www.readbyqxmd.com/read/29696048/a-comparison-of-emotional-behavioral-problems-of-siblings-at-the-age-range-of-3-9-year-old-children-with-autism-and-down-syndrome
#20
Nahid Pourbagheri, Navid Mirzakhani, Alireza Akbarzadehbaghban
Objective: Children's emotional-behavioral problems will have a huge impact on their future. Such problems are more seen in the siblings of children with special needs. The present study aimed to compare emotional-behavioral problems in the healthy siblings of autistic children with the healthy siblings of children with Down syndrome in order to identify such children in Iran. Materials & Methods: This descriptive study was carried out in Tehran, Iran in 2016 on 174 healthy children aged between 3 and 9 yr old among whom 58 cases had autistic siblings, 58 cases had siblings with Down syndrome, and 58 cases had typically development siblings...
2018: Iranian Journal of Child Neurology
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