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https://www.readbyqxmd.com/read/29236353/iccs-escca-consensus-guidelines-for-the-high-sensitivity-flow-cytometric-detection-of-paroxysmal-nocturnal-hemoglobinuria-pnh-part-2-assay-optimization-and-reagent-selection
#1
EDITORIAL
D Robert Sutherland, Andrea Illingworth, Iuri Marinov, Fernando Ortiz, John Andreasen, Dan Payne, Paul K Wallace, Michael Keeney
Since publication in 2010 of the International Clinical Cytometry Society (ICCS) Consensus Guidelines for detection of Paroxysmal nocturnal hemoglobinuria (PNH) by flow cytometery, a great deal of work has been performed to develop, optimize and validate a number of high-sensitivity assays to detect PNH phenotypes in both Red Blood Cells (RBCs) and White Blood Cells (WBCs, neutrophils and monocytes). This section (Part 2) of the updated ICCS PNH Consensus Guidelines will focus on specific instrument setup for these PNH assays, the identification and proper testing of appropriate antibody conjugates and combinations therof, and basic assay design...
December 13, 2017: Cytometry. Part B, Clinical Cytometry
https://www.readbyqxmd.com/read/29232891/the-effect-of-polyphenol-rich-interventions-on-cardiovascular-risk-factors-in-haemodialysis-a-systematic-review-and-meta-analysis
#2
REVIEW
Wolfgang Marx, Jaimon Kelly, Skye Marshall, Stacey Nakos, Katrina Campbell, Catherine Itsiopoulos
End-stage kidney disease is a strong risk factor for cardiovascular-specific mortality. Polyphenol-rich interventions may attenuate cardiovascular disease risk factors; however, this has not been systematically evaluated in the hemodialysis population. Using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, the following databases were searched: Cochrane Library (http://www.cochranelibrary.com/), MEDLINE (https://health.ebsco.com/products/medline-with-full-text), Embase (https://www...
December 11, 2017: Nutrients
https://www.readbyqxmd.com/read/29232277/scaling-up-hiv-self-testing-in-sub-saharan-africa-a-review-of-technology-policy-and-evidence
#3
Pitchaya P Indravudh, Augustine T Choko, Elizabeth L Corbett
PURPOSE OF REVIEW: HIV self-testing (HIVST) can provide complementary coverage to existing HIV testing services and improve knowledge of status among HIV-infected individuals. This review summarizes the current technology, policy and evidence landscape in sub-Saharan Africa and priorities within a rapidly evolving field. RECENT FINDINGS: HIVST is moving towards scaled implementation, with the release of WHO guidelines, WHO prequalification of the first HIVST product, price reductions of HIVST products and a growing product pipeline...
December 9, 2017: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/29231897/assessment-of-a-salt-reduction-intervention-on-adult-population-salt-intake-in-fiji
#4
Arti Pillay, Kathy Trieu, Joseph Alvin Santos, Arleen Sukhu, Jimaima Schultz, Jillian Wate, Colin Bell, Marj Moodie, Wendy Snowdon, Gary Ma, Kris Rogers, Jacqui Webster
Reducing population salt intake is a global public health priority due to the potential to save lives and reduce the burden on the healthcare system through decreased blood pressure. This implementation science research project set out to measure salt consumption patterns and to assess the impact of a complex, multi-faceted intervention to reduce population salt intake in Fiji between 2012 and 2016. The intervention combined initiatives to engage food businesses to reduce salt in foods and meals with targeted consumer behavior change programs...
December 12, 2017: Nutrients
https://www.readbyqxmd.com/read/29230179/transplacental-nutrient-transport-mechanisms-of-intrauterine-growth-restriction-in-rodent-models-and-humans
#5
REVIEW
Elke Winterhager, Alexandra Gellhaus
Although the causes of intrauterine growth restriction (IUGR) have been intensively investigated, important information is still lacking about the role of the placenta as a link from adverse maternal environment to adverse pregnancy outcomes of IUGR and preterm birth. IUGR is associated with an increased risk of cardiovascular, metabolic, and neurological diseases later in life. Determination of the most important pathways that regulate transplacental transport systems is necessary for identifying marker genes as diagnostic tools and for developing drugs that target the molecular pathways...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29229955/effect-of-whole-milk-compared-with-skimmed-milk-on-fasting-blood-lipids-in-healthy-adults-a-3-week-randomized-crossover-study
#6
Sara Engel, Mie Elhauge, Tine Tholstrup
BACKGROUND/OBJECTIVES: Dietary guidelines have for decades recommended choosing low-fat dairy products due to the high content of saturated fat in dairy known to increase blood concentration of LDL cholesterol. However, meta-analyses including observational studies show no association between overall dairy intake and risk of cardiovascular disease and even point to an inverse association with type 2 diabetes. The objective was to compare the effects of whole milk (3.5% fat) with skimmed milk (0...
December 11, 2017: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29229321/the-role-of-aspirin-heparin-and-other-interventions-in-the-prevention-and-treatment-of-fetal-growth-restriction
#7
REVIEW
Katie M Groom, Anna L David
Fetal growth restriction and related placental pathologies such as preeclampsia, stillbirth, and placental abruption are believed to arise in early pregnancy when inadequate remodeling of the maternal spiral arteries leads to persistent high-resistance and low-flow uteroplacental circulation. The consequent placental ischaemia, reperfusion injury, and oxidative stress are associated with an imbalance in angiogenic/antiangiogenic factors. Many interventions have centered on the prevention and/or treatment of preeclampsia with results pertaining to fetal growth restriction and small-for-gestational-age pregnancy often included as secondary outcomes because of the common pathophysiology...
December 8, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29229228/factors-influencing-norvancomycin-concentration-in-plasma-and-cerebrospinal-fluid-in-patients-after-craniotomy-and-dosing-guideline-a-population-approach
#8
Xingang Li, Yuanxing Wu, Shusen Sun, Qiang Wang, Zhigang Zhao
PURPOSE: Antibacterial spectrum and activity of norvancomycin are comparable with vancomycin, and it has been widely used in China. Norvancomycin can penetrate into the cerebrospinal fluid (CSF) through the damaged blood-brain barrier in patients after craniotomy. Because higher inter-individual variability was observed, we aimed to identify factors related to drug concentration to guide clinicians with norvancomycin dosing. METHODS: After craniotomy, patients with an indwelling catheter in the operational area/ventricle were intravenously administered norvancomycin...
December 8, 2017: Clinical Therapeutics
https://www.readbyqxmd.com/read/29228946/a-school-based-intervention-improved-dietary-intake-outcomes-and-reduced-waist-circumference-in-adolescents-a-cluster-randomized-controlled-trial
#9
Angélica Ochoa-Avilés, Roosmarijn Verstraeten, Lieven Huybregts, Susana Andrade, John Van Camp, Silvana Donoso, Patricia Liliana Ramírez, Carl Lachat, Lea Maes, Patrick Kolsteren
BACKGROUND: In Ecuador, adolescents' food intake does not comply with guidelines for a healthy diet. Together with abdominal obesity adolescent's inadequate diets are risk factors for non-communicable diseases. We report the effectiveness of a school-based intervention on the dietary intake and waist circumference among Ecuadorian adolescents. METHODS: A pair-matched cluster randomized controlled trial including 1430 adolescents (12-14 years old) was conducted...
December 11, 2017: Nutrition Journal
https://www.readbyqxmd.com/read/29228096/the-new-acc-aha-hypertension-guidelines-for-the-prevention-detection-evaluation-and-management-of-high-blood-pressure-in-adults
#10
John M Flack, David Calhoun, Ernesto L Schiffrin
No abstract text is available yet for this article.
December 7, 2017: American Journal of Hypertension
https://www.readbyqxmd.com/read/29227869/reliability-of-oscillometric-central-blood-pressure-responses-to-lower-limb-resistance-exercise
#11
Simon Fryer, Keeron Stone, Tabitha Dickson, James Faulkner, Danielle Lambrick, Pablo Corres, Lauren Jerred, Lee Stoner
BACKGROUND AND AIMS: Although it is well known that resistance training (RT) is beneficial for patients suffering from a variety of cardiovascular diseases, it remains underutilized as a rehabilitation tool as there is no reliable way to monitor the additional stress placed on the central organs. The current study aimed to determine between-day reliability of central haemodynamic indices using oscillometric pulse wave analysis (PWA) during progressive sub-maximal RT. METHODS: Nineteen healthy young males were tested on 3 different mornings in a fasted state...
December 5, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29226971/intravenous-dexamethasone-for-prophylaxis-of-postoperative-nausea-and-vomiting-after-administration-of-long-acting-neuraxial-opioids-a-systematic-review-and-meta-analysis
#12
REVIEW
S Grape, I Usmanova, K R Kirkham, E Albrecht
Long-acting neuraxial opioids provide excellent analgesia after surgery, but are associated with higher rates of postoperative nausea and vomiting. Dexamethasone effectively prevents postoperative nausea and vomiting after general anaesthesia, but its value in patients receiving long-acting neuraxial opioids is undetermined. Therefore, the objective of this meta-analysis was to assess the prophylactic anti-emetic efficacy of intravenous (i.v.) dexamethasone in this population. The study methodology followed the PRISMA statement guidelines...
December 11, 2017: Anaesthesia
https://www.readbyqxmd.com/read/29225163/impact-of-dose-adjusted-melphalan-in-obese-patients-undergoing-autologous-stem-cell-transplantation
#13
Kendall Shultes, Christopher Arp, Keith Stockerl-Goldstein, Kathryn Trinkaus, Sean DeFrates
BACKGROUND: Limited guidance exists for dosing melphalan (MEL) for autologous stem cell transplantation (ASCT) in the obese patient population as the current literature reports conflicting clinical outcomes between obese and non-obese patients. In 2014, the American Society for Blood and Marrow Transplantation published conditioning chemotherapy dosing guidelines for obese patients and recommended MEL be dosed utilizing actual body weight (ABW) in the body surface area calculation. Practice at Barnes-Jewish Hospital has consistently been to dose MEL using an adjusted body weight (AdBW) with a 20% correction when patients weigh greater than or equal to 120% their ideal body weight (IBW)...
December 7, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29224633/over-the-counter-medicines-and-diabetes-care
#14
Jeff Taylor
OBJECTIVES: People with diabetes turn to over-the-counter (OTC) medicines for many ailments. The focus of this brief review is the impact common OTC medicines might have on this group of patients. METHODS: Three types of OTC medicines were selected as most deserving of attention: 3 herbal agents, nonsteroidal anti-inflammatory drugs (NSAIDs) and cough/cold products. Existing literature was used to determine precautions that might be in order. RESULTS: Herbal/natural agents with the potential to impact blood sugar have been identified in various reports...
December 2017: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/29224263/-strategies-for-the-prevention-and-control-of-bleeding-due-to-vascular-injury-in-thoracoscopic-lung-surgery
#15
J D Mei, Q Pu, L Ma, C W Liu, L X Liu
The technique of thoracoscopic lung surgery has gradually matured. Nowadays, thoracoscope is recommended as the most preferred approach for surgical treatment of early stage non-small cell lung cancer in different guidelines. However, there are still some cases of accidential major bleeding due to vascular injury during thoracoscopic lung surgery. The wall of the hilum vessels is relatively thin. These vessels often involve a great portion of the cardiac output blood flow. Once the injury happened, the emergent condition may be life-threatening due to massive blood loss...
December 1, 2017: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/29223725/transfusion-associated-circulatory-overload-a-survey-among-dutch-intensive-care-fellows
#16
R B Klanderman, I Attaye, J J Bosboom, D P Veelo, B F Geerts, A P J Vlaar
OBJECTIVES: Transfusion-associated circulatory overload (TACO) is a severe pulmonary transfusion reaction and leading cause of transfusion-related morbidity and mortality in Europe. TACO is of particular importance in critically ill patients, since they often receive blood transfusions and have multiple risk factors for TACO. This study investigates transfusion practices in patients at risk of developing TACO, and furthermore knowledge concerning risk factors, diagnoses and treatment strategies among Dutch intensive care unit (ICU) fellows...
December 6, 2017: Transfusion Clinique et Biologique: Journal de la Société Française de Transfusion Sanguine
https://www.readbyqxmd.com/read/29222338/blood-sample-transportation-by-pneumatic-transportation-systems-a-systematic-literature-review
#17
REVIEW
Mads Nybo, Merete E Lund, Kjell Titlestad, Christian U Maegaard
BACKGROUND: Pneumatic transportation systems (PTSs) are increasingly used for transportation of blood samples to the core laboratory. Many studies have investigated the impact of these systems on different types of analyses, but to elucidate whether PTSs in general are safe for transportation of blood samples, existing literature on the subject was systematically assessed. METHODS: A systematic literature review was conducted following the preferred reporting items for systematic reviews and metaanalyses (PRISMA) Statement guidelines to gather studies investigating the impact of PTS on analyses in blood samples...
December 8, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/29222286/improving-emergency-department-based-care-of-sickle-cell-pain
#18
REVIEW
Jeffrey A Glassberg
Pain is the leading cause of emergency department (ED) visits for individuals living with sickle cell disease (SCD). The care that is delivered in the ED is often cited by patients with SCD as the area of health care in greatest need of improvement. In 2014, the National Heart, Lung, and Blood Institute released guidelines for the care of SCD, including recommendations for the management of acute sickle cell pain in the ED. These guidelines provide a framework to understand the elements of ideal emergency sickle cell pain care; however, they do not provide guidance on barriers and facilitators to achieving these ideals in the complex system of the ED...
December 8, 2017: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/29222285/five-lessons-learned-about-long-term-pain-management-in-adults-with-sickle-cell-disease
#19
REVIEW
Joshua J Field
Chronic pain affects one-half of adults with sickle cell disease (SCD). Despite the prevalence of chronic pain, few studies have been performed to determine the best practices for this patient population. Although the pathophysiology of chronic pain in SCD may be different from other chronic pain syndromes, many of the guidelines outlined in the pain literature and elsewhere are applicable; some were consensus-adopted in the 2014 National Heart, Lung, and Blood Institute SCD Guidelines. Recommended practices, such as controlled substance agreements and monitoring of urine, may seem unnecessary or counterproductive to hematologists...
December 8, 2017: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/29222034/management-of-invasive-candidiasis-and-candidemia-in-critically-ill-adults-expert-opinion-of-the-european-society-of-anaesthesia-esa-intensive-care-scientific-subcommittee
#20
REVIEW
Ruth-Aoibheann OLeary, Sharon Einav, Marc Leone, Krisztina Madách, Claude Martin, Ignacio Martin-Loeches
OBJECTIVE: The global burden of invasive fungal disease is increasing. Candida albicans remains the leading cause of fungal blood stream infections although non-albicans Candidal infections are emerging. Areas of controversy regarding diagnosis and management are hampering our ability to respond effectively to this evolving threat. The purpose of this narrative review is to address current controversies and provide recommendations to supplement guidelines. DIAGNOSIS OF INVASIVE CANDIDIASIS: Diagnosis of invasive candidiasis requires a combination of diagnostic tests and patient risk factors...
December 5, 2017: Journal of Hospital Infection
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