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Aye Chan Maung, Madhavan Hennessey, Raghunath Kadiyala
We report a case of a woman presenting with acute onset of delirium following ingestion of Amanita muscaria mushrooms for anxiolytic effect. Immediate diagnosis was obtained after taking a detailed history and confirmation with online poison database images. She fully recovered with supportive treatment and was discharged 24 hours after presentation. To the best of our knowledge, this is the first case report on A muscaria mushroom poisoning in the UK.
July 2023: Clinical Medicine: Journal of the Royal College of Physicians of London
#2
JOURNAL ARTICLE
Yesenia Pacheco-Hernández, Nemesio Villa-Ruano, Edmundo Lozoya-Gloria, Estafania de Jesus Terán-Sánchez, Elvia Becerra-Martínez
The 1H NMR metabolomics profiling of six edible mushrooms consumed in the northeastern highlands of Puebla, Mexico is presented. These fungi were morpho- and molecularly identified as Infundibulicybe squamulosa, Amanita jacksonii, Lepista nuda, Russula delica, Russula brevipes, and Lactarius indigo. The chemical profiling confirmed the presence of eight essential amino acids and their derivatives, six organic acids, six nucleosides, low amounts of reducing sugars, and valuable nutraceuticals such as betaine, carnitine, glycero-3-phosphocholine and O-acetylcarnitine which were differentially determined and quantified in the six mushrooms by qNMR...
April 10, 2024: Chemistry & Biodiversity
#3
JOURNAL ARTICLE
P W Crous, E R Osieck, R G Shivas, Y P Tan, S L Bishop-Hurley, F Esteve-Raventós, E Larsson, J J Luangsa-Ard, F Pancorbo, S Balashov, I G Baseia, T Boekhout, S Chandranayaka, D A Cowan, R H S F Cruz, P Czachura, S De la Peña-Lastra, F Dovana, B Drury, J Fell, A Flakus, R Fotedar, Ž Jurjević, A Kolecka, J Mack, G Maggs-Kölling, S Mahadevakumar, A Mateos, S Mongkolsamrit, W Noisripoom, M Plaza, D P Overy, M Piątek, M Sandoval-Denis, J Vauras, M J Wingfield, S E Abell, A Ahmadpour, A Akulov, F Alavi, Z Alavi, A Altés, P Alvarado, G Anand, N Ashtekar, B Assyov, G Banc-Prandi, K D Barbosa, G G Barreto, J-M Bellanger, J L Bezerra, D J Bhat, P Bilański, T Bose, F Bozok, J Chaves, D H Costa-Rezende, C Danteswari, V Darmostuk, G Delgado, S Denman, A Eichmeier, J Etayo, G Eyssartier, S Faulwetter, K G G Ganga, Y Ghosta, J Goh, J S Góis, D Gramaje, L Granit, M Groenewald, G Gulden, L F P Gusmão, A Hammerbacher, Z Heidarian, N Hywel-Jones, R Jankowiak, M Kaliyaperumal, O Kaygusuz, K Kezo, A Khonsanit, S Kumar, C H Kuo, T Læssøe, K P D Latha, M Loizides, S M Luo, J G Maciá-Vicente, P Manimohan, P A S Marbach, P Marinho, T S Marney, G Marques, M P Martín, A N Miller, F Mondello, G Moreno, K T Mufeeda, H Y Mun, T Nau, T Nkomo, A Okrasińska, J P A F Oliveira, R L Oliveira, D A Ortiz, J Pawłowska, M À Pérez-De-Gregorio, A R Podile, A Portugal, N Privitera, K C Rajeshkumar, I Rauf, B Rian, A Rigueiro-Rodríguez, G F Rivas-Torres, P Rodriguez-Flakus, M Romero-Gordillo, I Saar, M Saba, C D Santos, P V S R N Sarma, J L Siquier, S Sleiman, M Spetik, K R Sridhar, M Stryjak-Bogacka, K Szczepańska, H Taşkın, D S Tennakoon, D Thanakitpipattana, J Trovão, I Türkekul, A L van Iperen, P van 't Hof, G Vasquez, C M Visagie, B D Wingfield, P T W Wong, W X Yang, M Yarar, O Yarden, N Yilmaz, N Zhang, Y N Zhu, J Z Groenewald
Novel species of fungi described in this study include those from various countries as follows: Australia , Aschersonia mackerrasiae on whitefly, Cladosporium corticola on bark of Melaleuca quinquenervia , Penicillium nudgee from soil under Melaleuca quinquenervia , Pseudocercospora blackwoodiae on leaf spot of Persoonia falcata , and Pseudocercospora dalyelliae on leaf spot of Senna alata . Bolivia , Aspicilia lutzoniana on fully submersed siliceous schist in high-mountain streams, and Niesslia parviseta on the lower part and apothecial discs of Erioderma barbellatum on a twig...
June 2023: Persoonia
#4
REVIEW
Deyuan Ning, Jinfang Xue, Xiran Lou, Ruifei Shao, Yu Liu, Guobing Chen
Amanita phalloides is the primary species responsible for fatal mushroom poisoning, as its main toxin, α-amanitin, irreversibly and potently inhibits eukaryotic RNA polymerase II (RNAP II), leading to cell death. There is no specific antidote for α-amanitin, which hinders its clinical application. However, with the advancement of precision medicine in oncology, including the development of antibody-drug conjugates (ADCs), the potential value of various toxic small molecules has been explored. These ADCs ingeniously combine the targeting precision of antibodies with the cytotoxicity of small-molecule payloads to precisely kill tumor cells...
March 30, 2024: Archives of Toxicology
#5
JOURNAL ARTICLE
Matthew Tobias, Mary McGoldrick, Mary Rometti, Jessica Laub, Grant Wei, Denise Fernandez
INTRODUCTION: Mushroom toxicity is an important etiology of acute liver injury in a patient with gastrointestinal symptoms. CASE REPORT: We present the case of a male patient presenting to the emergency department (ED) with gastrointestinal distress who was placed under ED observation for elevated liver function tests. During his hospital course, it was revealed he had consumed wild mushrooms believed to be Amanita phalloides . CONCLUSION: While mushroom ingestion and subsequent toxicity are rare, a high index of suspicion in foraging hobbyists is essential to arriving at the correct diagnosis and directing the patient to the appropriate management...
February 2024: Clinical Practice and Cases in Emergency Medicine
#6
Parker G Jobin, Connor Stewart, Aarshi Vipani, Ingrid Perez-Alvarez, Samuel Pepkowitz, Ellen Klapper, Anders Berg, Kaytlena Stillman, Sam Torbati, Alexander Kuo, Hirsh Trivedi, Ju Dong Yang, Jonathan Steinberger, Richard J Van Allan, Oren Friedman, Kathryn Cardoza, Walid S Ayoub
[This corrects the article DOI: 10.14309/crj.0000000000001246.].
March 2024: ACG Case Reports Journal
#7
JOURNAL ARTICLE
Rhim Ryoo, Hyorim Lee, Youngki Park
Coronaviruses (CoV) are among the major viruses that cause common cold in humans. Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a high-risk human pathogen that derived from bat coronaviruses, although several other animals serve as CoV hosts, contributing to human infection. As the human activity area expanded, viruses previously prevalent only in animals mutated and became threats to humans as well, leading to worldwide epidemics. Therefore, controlling CoV infections in animals is essential to prevent CoV-related human infections...
2024: International Journal of Medicinal Mushrooms
#8
JOURNAL ARTICLE
Yu Zhang, Shuifang Zhu, Chaonan Wang, Junxia Shi, Jiayao He, Jian Chen, Liang Liang, Fan Jiang
Amanita exitialis, a deadly mushroom found in eastern Asia, causes the highest death rates among all poisonous mushrooms in China. The aim of the present study was to develop an efficient, accurate, and user-friendly PCR-based method for identifying A. exitialis that could facilitate the prevention, diagnosis, and treatment of associated food poisoning. A. exitialis-specific primers and probes were designed based on the internal transcribed spacer region variations of 27 mushroom species. Specificity was confirmed using conventional and real-time PCR for 23 non-target mushroom species, including morphologically similar and closely related species...
March 20, 2024: Food Chemistry
#9
JOURNAL ARTICLE
Nuri Cenk Coskun, Seyma Buyucek
Amanita phalloides poisoning is known to be the most fatal case among mushroom poisoning cases. Its main mechanism of toxicity is that it leads to cell death by the irreversible binding of its toxins to the DNA-dependent RNA polymerase II enzyme. This study was planned to analyze the effects of the CDP-choline molecule on Amanita phalloides mushroom poisoning cases. The extract of the Amanita phalloides mushroom was taken and intraperitoneally administered to male Wistar Albino rats at a dose of 0.3 g/kg...
March 12, 2024: Toxicon: Official Journal of the International Society on Toxinology
#10
REVIEW
Jurriaan Varekamp, Jia Lin Tan, Janine Stam, Aad P van den Berg, Patrick F van Rheenen, Daan J Touw, Bart G J Dekkers
BACKGROUND: Interruption of the enterohepatic circulation is regarded as an effective way to treat patients with amatoxin poisoning. Nonetheless, its effectiveness has not yet been systematically evaluated. Therefore, we performed a systematic review to investigate the role of enterohepatic circulation on patient outcome and clinical laboratory values. We specifically sought to evaluate the effect of activated charcoal, which absorbs drugs and toxins in the gastrointestinal tract. METHODS: A previously established database with data extracted from case reports and series from literature, supplemented with recent publications, was used...
February 27, 2024: Clinical Toxicology
#11
JOURNAL ARTICLE
Kubra Durkan, Cigdem Ichedef, Elif Baris, M Aylin Arici
Mushroom poisonings caused by Amanita phalloides are the leading cause of mushroom-related deaths worldwide. Alpha-Amanitin (α-AMA), a toxic substance present in these mushrooms, is responsible for the resulting hepatotoxicity and nephrotoxicity. The objective of our study was to determine the distribution of α-AMA in Balb/c mice by labeling with Iodine-131. Mice were injected with a toxic dose (1.4 mg/kg) of α-AMA labeled with Iodine-131. The mice were sacrificed at the 1st, 2nd, 4th, 8th, 24th, and 48th hours under anesthesia...
February 24, 2024: Toxicon: Official Journal of the International Society on Toxinology
#12
JOURNAL ARTICLE
Miranda Visser, Willemien F J Hof, Astrid M Broek, Amanda van Hoek, Joyce J de Jong, Daan J Touw, Bart G J Dekkers
INTRODUCTION: Amanita phalloides poisoning is a serious health problem with a mortality rate of 10-40%. Poisonings are characterized by severe liver and kidney toxicity. The effect of Amanita phalloides poisonings on hematological parameters has not been systematically evaluated thus far. METHODS: Patients with suspected Amanita phalloides poisonings were retrospectively selected from the hospital database of the University Medical Center Groningen (UMCG). Medical data-including demographics; liver, kidney, and blood parameters; treatment; and outcomes-were collected...
January 29, 2024: Toxins
#13
JOURNAL ARTICLE
Grace Kropelin, Clare H Scott Chialvo
Understanding the often antagonistic plant-herbivore interactions and how host defenses can influence herbivore dietary breadth is an area of ongoing study in ecology and evolutionary biology. Typically, host plants/fungi that produce highly noxious chemical defenses are only fed on by specialists. We know very little about generalist species that can feed and develop on a noxious host. One such example of generalists feeding on toxic host occurs in the mushroom-feeding Drosophila found in the immigrans-tripunctata radiation...
February 2024: Ecology and Evolution
#14
JOURNAL ARTICLE
Renhe Duan, Jiahui Huang, Donghan Zhang, Enjing Tian
Amanita section Phalloideae consists of lethal toxic mushroom species, causing many fatal poisoning incidents worldwide. Molecular techniques of nucleotide signatures and single nucleotide polymorphism (SNP) detection could be used to develop a specific method for identifying lethal section (sect.) Phalloideae species. A comparison of 38 sequenced and 228 validated sequences from sect. Phalloideae species showed a 17-base pair nucleotide signature and an SNP site between the lethal and non-lethal species. A specific minor groove binder probe was designed based on them...
2024: Frontiers in Microbiology
#15
JOURNAL ARTICLE
Mazulkieliche Jeronimo Dos Reis, Lucas Leonardo-Silva, Solange Xavier-Santos
BACKGROUND: Environmental perception involves the interpretation and interaction of individuals with their surroundings, influenced by cultural, social, and individual factors. Analyzing the environmental perception of children and adolescents contributes to fostering awareness and ethical behavior toward the environment. Indigenous communities, such as the Karajá from Brazil, possess significant environmental knowledge due to their connection with nature, providing distinctive insights into biodiversity and natural interconnections...
February 10, 2024: Journal of Ethnobiology and Ethnomedicine
#16
JOURNAL ARTICLE
Chenggen Xiao, Guoqing Huang, Xiaoxia Cao, Xiangmin Li
BACKGROUND: Mushroom poisoning is one of the most prominent public health problems. However, there is no special antidote so far. In the present study, we verified that Ganoderma lucidum may be an effective approach for treatment of acute mushroom poisoning. METHODS: A retrospective study was performed within the past 20 years, we compiled information on the treatment of α-Amatoxin mushroom poisoning with Ganoderma lucidum by evaluating the mortality rate and liver function before and after treatment...
2024: American Journal of Translational Research
#17
Zhifan He, Xiaohui Li, Min Feng, Xixi Wang, Yao Wang, Jianxin Chen
Wild mushroom poisoning is a global public health concern, with mushrooms containing amatoxins being the main cause of fatalities. Mushrooms from the genus Amanita and Galerina contain amatoxins. Here we present a case of wild mushroom poisoning that affected three individuals, resulting in two fatalities. Within 10-15 hours after consumption, they experienced symptoms of gastroenteritis such as vomiting, abdominal pain, and diarrhea. One individual sought medical attention promptly and recovered, while the other two sought medical help nearly two or three days after the onset of symptoms, by which time their conditions had already worsened and led to their deaths...
February 3, 2024: Toxicon: Official Journal of the International Society on Toxinology
#18
JOURNAL ARTICLE
Pinky Rani Biswas, Pinaki Chattopadhyay, Sudeshna Nandi, Arabinda Ghosh, Krishnendu Acharya, Arun Kumar Dutta
In humans, a wide range of health disorders have been induced due to an imbalanced metabolism and an excess generation of reactive oxygen species (ROS). Different biological properties found in mushrooms seem to be the reason for their customary use as a favourite delicacy. Therefore, exploration of wild edible mushrooms as a source of various biological compounds is gaining much importance today. Amanita konajensis, one of the underutilized macrofungi popularly consumed in Eastern India, demands a systematic study of its medicinal values...
2024: International Journal of Medicinal Mushrooms
#19
JOURNAL ARTICLE
Willemien F J Hof, Miranda Visser, Joyce J de Jong, Marian N Rajasekar, Jan Jacob Schuringa, Inge A M de Graaf, Daan J Touw, Bart G J Dekkers
Amanita phalloides poisonings account for the majority of fatal mushroom poisonings. Recently, we identified hematotoxicity as a relevant aspect of Amanita poisonings. In this study, we investigated the effects of the main toxins of Amanita phalloides , α- and β-amanitin, on hematopoietic cell viability in vitro. Hematopoietic cell lines were exposed to α-amanitin or β-amanitin for up to 72 h with or without the pan-caspase inhibitor Z-VAD(OH)-FMK, antidotes N-acetylcysteine, silibinin, and benzylpenicillin, and organic anion-transporting polypeptide 1B3 (OATP1B3) inhibitors rifampicin and cyclosporin...
January 22, 2024: Toxins
#20
JOURNAL ARTICLE
Baopu Lv, Liang Liu, Hao Xiao, Qingbing Meng, Rui Zhang, Yaqing An, Yingli Jin, Yu Ma, Hengbo Gao, Yongkai Li, Qian He, Yutao Zhang, Changqing Liu, Xiaoyan Luo, Xiaomin Xu, Fenshuang Zheng, Yingping Tian, Hongshun Zhang, Dongqi Yao
WHAT IS ALREADY KNOWN ABOUT THIS TOPIC?: Fatal poisonings caused by wild mushrooms containing amanita toxins pose a significant threat in the southern regions of China. These toxins primarily induce gastrointestinal symptoms initially, which are then followed by potentially life-threatening acute liver damage. WHAT IS ADDED BY THIS REPORT?: This report contributes to the existing knowledge on these cases of poisoning by documenting the second occurrences in Hebei Province and the first occurrences in Xingtai City...
January 19, 2024: China CDC weekly
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