keyword
MENU ▼
Read by QxMD icon Read
search

Hepatotoxin

keyword
https://www.readbyqxmd.com/read/28073545/a-validated-uplc-ms-ms-method-for-the-surveillance-of-ten-aquatic-biotoxins-in-european-brackish-and-freshwater-systems
#1
Brett Greer, Sara E McNamee, Bas Boots, Lucia Cimarelli, Delphine Guillebault, Karim Helmi, Stefania Marcheggiani, Stefan Panaiotov, Ulrich Breitenbach, Reyhan Akçaalan, Linda K Medlin, Katrin Kittler, Christopher T Elliott, Katrina Campbell
Over the past few decades, there has been an increased frequency and duration of cyanobacterial Harmful Algal Blooms (HABs) in freshwater systems globally. These can produce secondary metabolites called cyanotoxins, many of which are hepatotoxins, raising concerns about repeated exposure through ingestion of contaminated drinking water or food or through recreational activities such as bathing/swimming. An ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) multi-toxin method has been developed and validated for freshwater cyanotoxins; microcystins-LR, -YR, -RR, -LA, -LY and -LF, nodularin, cylindrospermopsin, anatoxin-a and the marine diatom toxin domoic acid...
May 2016: Harmful Algae
https://www.readbyqxmd.com/read/28073507/evidence-of-freshwater-algal-toxins-in-marine-shellfish-implications-for-human-and-aquatic-health
#2
Corinne M Gibble, Melissa B Peacock, Raphael M Kudela
The occurrence of freshwater harmful algal bloom toxins impacting the coastal ocean is an emerging threat, and the potential for invertebrate prey items to concentrate toxin and cause harm to human and wildlife consumers is not yet fully recognized. We examined toxin uptake and release in marine mussels for both particulate and dissolved phases of the hepatotoxin microcystin, produced by the freshwater cyanobacterial genus Microcystis. We also extended our experimental investigation of particulate toxin to include oysters (Crassostrea sp...
November 2016: Harmful Algae
https://www.readbyqxmd.com/read/28073477/a-review-of-the-phylogeny-ecology-and-toxin-production-of-bloom-forming-aphanizomenon-spp-and-related-species-within-the-nostocales-cyanobacteria
#3
REVIEW
Samuel Cirés, Andreas Ballot
The traditional genus Aphanizomenon comprises a group of filamentous nitrogen-fixing cyanobacteria of which several memebers are able to develop blooms and to produce toxic metabolites (cyanotoxins), including hepatotoxins (microcystins), neurotoxins (anatoxins and saxitoxins) and cytotoxins (cylindrospermopsin). This genus, representing geographically widespread and extensively studied cyanobacteria, is in fact heterogeneous and composed of at least five phylogenetically distant groups (Aphanizomenon, Anabaena/Aphanizomenon like cluster A, Cuspidothrix, Sphaerospermopsis and Chrysosporum) whose taxonomy is still under revision...
April 2016: Harmful Algae
https://www.readbyqxmd.com/read/28063643/protective-effect-of-tritone-livosone-on-oxidative-dna-damage-and-its-hepatoprotective-potential-against-various-hepatotoxic-agent-in-wistar-rats
#4
Sheetal Kashinath Medhekar, Tejas Pandurang Jadhav, Vishal Sadashiv Sasane, Vikas Suresh Shende, Nagesh Hanmantrao Aloorkar, Anjali Baburao Chincholkar, Girish Sudhakar Soman, Ajit Shankarrao Kulkarni
AIM: To evaluate antioxidant activity, DNA damage inhibition and hepatoprotecitve potential of polyherbal formulation Tritone (Livosone). METHODS: In vitro antioxidant activity of Tritone formulation was performed by using DPPH assay. Hepatoprotecitve potential of Tritone was evaluated against various hepatotoxic agents including Paracetamol (2g/kg b. wt p.o. single dose on 15th day), Galactosamine (400mg/kg b. wt. i.p. single dose on 8th day) and Alcohol (30% p...
January 4, 2017: Experimental and Toxicologic Pathology: Official Journal of the Gesellschaft Für Toxikologische Pathologie
https://www.readbyqxmd.com/read/28062358/alterations-in-transcription-and-protein-expressions-of-hcc-related-genes-in-hepg2-cells-caused-by-microcystin-lr
#5
Xiaoyu Li, Xiangyang Zhang, Wenjie Xie, Chune Zhou, Yao Li, Xiuhua Zhang
Microcystin-LR (MC-LR) is the most common and toxic hepatotoxin and it could induce human hepatitis and hepatocellular carcinoma (HCC) via the route of drinking water. The aim of the present study was to determine the expressions of oncogenes c-fos, c-jun, c-myc, c-met, and N-ras and tumor suppressor gene PTEN in HepG2 cells following MC-LR-exposure to understand the possible mechanism of MC-LR-related human primary liver cancer. The results of qPCR and Western blotting showed that MC-LR-exposure at non- or sub-cytotoxic concentrations promoted the expressions of oncogenes c-fos, c-jun, c-myc, c-met, and N-ras while suppressed tumor-suppressor gene PTEN in HepG2 cells at both transcription and protein levels...
January 3, 2017: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/27956256/circulating-micrornas-possible-role-as-non-invasive-diagnostic-biomarkers-in-liver-disease
#6
Kishor Pant, Senthil K Venugopal
Liver is the central organ for metabolism and the hepatocytes metabolize several drugs, hepatotoxins, alcohol, etc. Continuous exposure of the hepatocytes to these toxins result in various chronic diseases, such as alcoholic liver disease, non-alcoholic fatty liver disease, viral hepatitis and hepatocellular carcinoma. Although several diagnostic methods, such as serum markers, liver biopsy or imaging studies are currently available, most of these are either invasive or detect the disease at advanced stages...
December 9, 2016: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/27909908/obesity-and-liver-cancer
#7
Krasimira Aleksandrova, Marta Stelmach-Mardas, Sabrina Schlesinger
Obesity and related metabolic disorders have become globally prevalent posing a challenge for the chronically damaged liver and predisposing the development and progression of cancer. The rising phenomenon of "obesity epidemic" may provide means for understanding why liver cancer is one of the few malignancies with rising incidence in developed countries over the last decades. Non-alcoholic fatty liver disease associated with obesity, insulin resistance, and type 2 diabetes is an increasingly recognized trigger for liver cancer in Western populations characterized by low prevalence of established risk factors for liver cancer such as viral hepatitis and hepatotoxin exposure...
2016: Recent Results in Cancer Research
https://www.readbyqxmd.com/read/27896398/acute-liver-effects-disposition-and-metabolic-fate-of-14-c-fenclozic-acid-following-oral-administration-to-normal-and-bile-cannulated-male-c57bl-6j-mice
#8
Kathryn Pickup, Scott Martin, Elizabeth A Partridge, Huw B Jones, Jonathan Wills, Tim Schulz-Utermoehl, Alan McCarthy, Alison Rodrigues, Chris Page, Kerry Ratcliffe, Sunil Sarda, Ian D Wilson
The distribution, metabolism, excretion and hepatic effects of the human hepatotoxin fenclozic acid were investigated following single oral doses of 10 mg/kg to normal and bile duct-cannulated male C57BL/6J mice. Whole body autoradiography showed distribution into all tissues except the brain, with radioactivity still detectable in blood, kidney and liver at 72 h post-dose. Mice dosed with [(14)C]-fenclozic acid showed acute centrilobular hepatocellular necrosis, but no other regions of the liver were affected...
November 28, 2016: Archives of Toxicology
https://www.readbyqxmd.com/read/27871602/hepatotoxicity-due-to-red-bush-tea-consumption-a-case-report
#9
Shamantha Reddy, Pragnyadipta Mishra, Sana Qureshi, Singh Nair, Tracey Straker
Many conventional drugs used today, including isoniazid, dapsone, and acetaminophen, are well recognized culprits of hepatotoxicity. With increasing use of complementary and alternative medical therapies, several herbal medicines, such as Ma-Huang, kava, and chaparral leaf, have been implicated as hepatotoxins. Hepatotoxicity may be the most frequent adverse reaction to these herbal remedies when taken in excessive quantities. A myriad of liver dysfunctions may occur including transient liver enzyme abnormalities due to acute and chronic hepatitis...
December 2016: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/27863346/a-diet-induced-sprague-dawley-rat-model-of-nonalcoholic-steatohepatitis-related-cirrhosis
#10
Mayuko Ichimura, Miki Masuzumi, Miku Kawase, Mika Sakaki, Shizuka Tamaru, Yasuo Nagata, Kazunari Tanaka, Kazuhito Suruga, Koichi Tsuneyama, Satoru Matsuda, Katsuhisa Omagari
Certain modified diets containing saturated fatty acids, cholesterol or fructose lead to the development of nonalcoholic steatohepatitis (NASH)-related fibrosis in rodents; however, progression to cirrhosis is rare. Experimental liver cirrhosis models have relied on genetic manipulation or administration of hepatotoxins. This study aimed to establish a reliable dietary model of NASH-related cirrhosis in a relatively short period. Male Sprague-Dawley rats (9 weeks of age) were randomly assigned to normal, high-fat (HF), or two types (1...
October 24, 2016: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/27842772/evolution-of-experimental-models-of-the-liver-to-predict-human-drug-hepatotoxicity-and-efficacy
#11
REVIEW
Lawrence A Vernetti, Andreas Vogt, Albert Gough, D Lansing Taylor
In this article, we review the past applications of in vitro models in identifying human hepatotoxins and then focus on the use of multiscale experimental models in drug development, including the use of zebrafish and human cell-based, 3-dimensional, microfluidic systems of liver functions as key components in applying Quantitative Systems Pharmacology (QSP). We have implemented QSP as a platform to improve the rate of success in the process of drug discovery and development of therapeutics.
February 2017: Clinics in Liver Disease
https://www.readbyqxmd.com/read/27746894/characterization-of-a-functional-c3a-liver-spheroid-model
#12
Harriet Gaskell, Parveen Sharma, Helen E Colley, Craig Murdoch, Dominic P Williams, Steven D Webb
More predictive in vitro liver models are a critical requirement for preclinical screening of compounds demonstrating hepatotoxic liability. 3D liver spheroids have been shown to have an enhanced functional lifespan compared to 2D monocultures; however a detailed characterisation of spatiotemporal function and structure of spheroids still needs further attention before widespread use in industry. We have developed and characterized the structure and function of a 3D liver spheroid model formed from C3A hepatoma cells...
June 1, 2016: Toxicology Research
https://www.readbyqxmd.com/read/27680771/gender-impacts-on-the-correlations-between-nonalcoholic-fatty-liver-disease-and-hypertension-in-a-chinese-population-aged-45-60-y
#13
Xi-Dong Li, Bing-Hua Qiu, Fang-Cheng Su, Shao-Xia Sun
: No previous study has reported the association between nonalcoholic fatty liver disease (NAFLD) and the risk of hypertension in the Chinese population. Therefore, the aim of this study was to evaluate the relationship between NAFLD and hypertension in a middle-aged Chinese population. The study subject was (a group of) 1006 Chinese adults aged 45-60 y in Shandong Province who participated in the Weifang Nutrition and Health Survey (2014-2015). Hypertension was defined as systolic blood pressure (SBP) ≥140 mmHg or diastolic blood pressure (DBP) ≥ 9 0mmHg...
2016: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/27623180/pequi-caryocar-brasiliense-camb-almond-oil-attenuates-carbon-tetrachloride-induced-acute-hepatic-injury-in-rats-antioxidant-and-anti-inflammatory-effects
#14
Lucillia R de O Torres, Fernanda C de Santana, Francisco L Torres-Leal, Illana L P de Melo, Luciana T Yoshime, Emidio M Matos-Neto, Marília C L Seelaender, Cintia M M Araújo, Bruno Cogliati, Jorge Mancini-Filho
Carbon tetrachloride (CCl4) is a potent hepatotoxin, capable of generating free radicals that lead to oxidative stress and the inflammation process. Pequi almond oil (PAO) has been reported to possess unsaturated fatty acid and antioxidant compounds related to beneficial effects on oxidation and inflammatory conditions. The present study was undertaken to evaluate the hepatoprotective effects of handmade and coldpressed PAO on CCl4-induced acute liver injury. The possible mechanisms underlying the effect on liver injury enzymes, histopathological parameters, lipid profile, lipid peroxidation, and antioxidant and detoxification defense systems, as well as inflammatory parameters, were determined...
November 2016: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/27575484/level-of-natural-hepatotoxin-indospicine-contamination-in-australian-camel-meat
#15
Eddie T T Tan, Rafat Al Jassim, Bruce R D'Arcy, Mary T Fletcher
Camel meat production for human consumption and pet food manufacture accounts for a relatively small part of overall red meat production in Australia. Reliable statistical data for the Australian production and consumption of camel meat are not available; however, it is estimated that 300,000 feral camels roam within the desert of central Australia, with an annual usage of more than 3000 camels for human consumption, 2000 for pet food manufacture and a smaller number for live export. Despite a small Australian camel meat production level, the usage of camel meat for pet food has been restricted in recent years due to reports of serious liver disease and death in dogs consuming camel meat...
October 2016: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/27515961/laboratory-tests-for-diagnosis-of-alcoholic-liver-disease
#16
REVIEW
Valentina Peta, Djamel Elaribi, Ludovico Abenavoli
Alcohol is considered one of the most common hepatotoxin, and chronic alcoholic liver disease is affecting millions of subjects worldwide. The three most frequently manifestations of alcoholic liver disease are steatosis, acute alcoholic hepatitis and liver cirrhosis. The diagnosis of Alcoholic Liver Diseases (ALD) is made by clinical and laboratory analysis. Actually do not exist a single laboratory test able to confirm the diagnosis of ALD, but in the last years several serum markers and laboratory abnormalities have been discovered in these patients...
2016: Reviews on Recent Clinical Trials
https://www.readbyqxmd.com/read/27509381/seasonal-and-species-variation-of-the-hepatotoxin-indospicine-in-australian-indigofera-legumes-as-measured-by-uplc-ms-ms
#17
Eddie T T Tan, Christopher M Materne, Richard G Silcock, Bruce R D'Arcy, Rafat Al Jassim, Mary T Fletcher
Livestock industries have maintained a keen interest in pasture legumes because of the high protein content and nutritive value. Leguminous Indigofera plant species have been considered as having high feeding values to be utilized as pasture, but the occurrence of the toxic constituent indospicine in some species has restricted this utility. Indospicine has caused both primary and secondary hepatotoxicosis and also reproductive losses, but has only previously been determined in a small number of Indigofera species...
August 31, 2016: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/27497728/zidovudine-and-isoniazid-induced-liver-toxicity-and-oxidative-stress-evaluation-of-mitigating-properties-of-silibinin
#18
Ramanathan Raghu, Sivanesan Karthikeyan
HIV/AIDS patients are more prone for opportunistic TB infections and they are administered the combined regimen of anti-retroviral drug zidovudine (AZT) and isoniazid (INH) for therapy. However, AZT+INH treatment has been documented to induce injury and remedial measures to prevent this adversity are not clearly defined. Silibinin (SBN) is a natural hepatoprotective principle isolated from medicinal plant Silybum marianum and is currently used for therapy of various liver diseases. This study investigate the hepatotoxic potentials of AZT alone, INH alone and AZT+INH treatments and the mitigating potentials of SBN against these drugs induced toxic insults of liver in rats...
September 2016: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/27477889/accumulation-persistence-and-effects-of-indospicine-residues-in-camels-fed-indigofera-plant
#19
Eddie T T Tan, Rafat Al Jassim, A Judy Cawdell-Smith, Selina M Ossedryver, Bruce R D'Arcy, Mary T Fletcher
Indospicine (l-2-amino-6-amidinohexanoic acid) is a natural hepatotoxin found in all parts of some Indigofera plants such as Indigofera linnaei and Indigofera spicata. Several studies have documented a susceptibility to this hepatotoxin in different species of animals, including cattle, sheep, dogs, and rats, which are associated with mild to severe liver disease after prolonged ingestion. However, there is little published data on the effects of this hepatotoxin in camels, even though Indigofera plants are known to be palatable to camels in central Australia...
August 31, 2016: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/27474713/physiological-and-proteomic-responses-of-continuous-cultures-of-microcystis-aeruginosa-pcc-7806-to-changes-in-iron-bioavailability-and-growth-rate
#20
Anna C Y Yeung, Paul M D'Agostino, Anne Poljak, James McDonald, Mark W Bligh, T David Waite, Brett A Neilan
UNLABELLED: The hepatotoxin microcystin (MCYST) is produced by a variety of freshwater cyanobacterial species, including Microcystis aeruginosa Interestingly, MCYST-producing M. aeruginosa strains have been shown to outcompete their nontoxic counterparts under iron-limiting conditions. However, the reasons for this are unclear. Here we examined the proteomic response of M. aeruginosa PCC 7806 continuous cultures under different iron and growth regimes. Iron limitation was correlated with a global reduction in levels of proteins associated with energy metabolism and photosynthesis...
October 1, 2016: Applied and Environmental Microbiology
keyword
keyword
70290
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"