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https://www.readbyqxmd.com/read/28231614/risk-factors-for-the-development-of-post-traumatic-stress-disorder-and-coping-strategies-in-mothers-and-fathers-following-infant-hospitalization-in-the-neonatal-intensive-care-unit
#1
Anna Aftyka, Beata Rybojad, Wojciech Rosa, Aleksandra Wróbel, Hanna Karakuła-Juchnowicz
OBJECTIVE: The development of Neonatal Intensive Care Units (NICUs) has increased the survival rate of infants. However, one of the major parental problems is post-traumatic stress disorder (PTSD). The aim of this study was to identify the potential risk factors for the development of PTSD in mothers and fathers following infant hospitalization in the NICU. DESIGN: An observational study covered 125 parents (72 mothers and 53 fathers) of infants aged three to 12 months who were hospitalized in the NICU during the neonatal period...
February 23, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28230705/determinant-variables-enteric-pathogen-burden-gut-function-and-immune-related-inflammatory-biomarkers-associated-with-childhood-malnutrition-a-prospective-case-control-study-in-northeastern-brazil
#2
Aldo Am Lima, Álvaro M Leite, Alessandra Di Moura, Noélia L Lima, Alberto M Soares, Cláudia B Abreu, José Quirino Filho, Rosa Ms Mota, Ila Fn Lima, Alexandre Havt, Pedro Hqs Medeiros, Mara Mg Prata, Marjorie M Guedes, Paloma A Cavalcante, Herlice N Veras, Ana Ks Santos, Sean R Moore, Relana C Pinkerton, Eric R Houpt, Richard L Guerrant
Malnutrition results in serious consequences for growth and cognitive development in children. We studied select child and maternal biological factors, socio-economic factors, enteric pathogenic burden, and gut function biomarkers in 402 children 6-24 months of age in North-eastern Brazil. In this prospective case-control study, not being fed colostrum (odds ratio [OR] = 3.29, 95% confidence interval [CI] 1.73-6.26), maternal age ≥18 years (OR = 1.88, 95% CI 1.10-3.22), and no electrical fan (OR = 2.46, 95% CI 1...
February 22, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28230268/potential-climate-change-health-risks-from-increases-in-heat-waves-abnormal-birth-outcomes-and-adverse-maternal-health-conditions
#3
Gulcan Cil, Trudy Ann Cameron
We investigate the risks presented by heat waves for adverse health conditions for babies and expectant mothers when these mothers have been exposed to heat waves during gestation or during the period just prior to conception. Rather than just birth weight and gestational age, we focus on less common metrics such as abnormal conditions in the newborn (fetal distress, reliance on a ventilator, and meconium aspiration) and adverse health conditions in the mother (pregnancy-related hypertension, uterine bleeding during pregnancy, eclampsia, and incompetent cervix)...
February 23, 2017: Risk Analysis: An Official Publication of the Society for Risk Analysis
https://www.readbyqxmd.com/read/28229835/-neurodevelopmental-outcomes-of-very-preterm-or-very-low-birth-weigth-infants-comparison-of-monochorionic-and-dichorionic-twins-with-singletons
#4
Adelaide Taborda, Guiomar Oliveira
INTRODUCTION: Twins are associated with a delayed development and cerebral palsy. The purpose of this work was to compare the neurologic morbidity in very preterm or very low birth weight dichorionic and monochorionic twins with singletons. MATERIAL AND METHODS: We conducted a retrospective cohort study of livebirths lowest through 32 weeks of gestation or very low weight infants admitted to Neonatal Intensive Care Unit of a level III hospital, between 2006 and 2010...
November 2016: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/28228962/conforming-with-current-regulation-in-turkey-regarding-the-freezing-of-oocytes-a-case-report-of-the-first-pregnancy-in-turkey-achieved-through-oocyte-vitrification
#5
Semra Kahraman, Kahraman Ulker, Caroline Pirkevi Çetinkaya, Yesim Kumtepe Colakoglu, Hakan K Yelke, Cihangir Yilanlioglu
OBJECTIVES: To present the first pregnancy achieved in Turkey with frozen-warmed oocytes in a case with previous nine unsuccessful assisted reproductive technology (ART) attempts. METHODS: The clinical follow-up of a 33-year-old female applying to our ART centre after a long and complicated history of infertility is described. RESULTS: In April 2013, the woman attempted our centre for her 10th ART trial. She informed us on oocyte pick-up (OPU) day that her husband had been hospitalized following a car crush in Albania and was unable to travel to our clinic to give a sperm sample...
2017: SAGE open medical case reports
https://www.readbyqxmd.com/read/28228961/concurrent-van-der-woude-syndrome-and-turner-syndrome-a-case-report
#6
Evan Los, Hayley Baines, Ines Guttmann-Bauman
Most cases of Van der Woude syndrome are caused by a mutation to interferon regulatory factor 6 on chromosome 1. Turner syndrome is caused by complete or partial absence of the second sex chromosome in girls. We describe a unique case of the two syndromes occurring concurrently though apparently independently in a girl with Van der Woude syndrome diagnosed at birth and Turner syndrome at 14 years 9 months. Short stature was initially misattributed to Van der Woude syndrome and pituitary insufficiency associated with clefts before correctly diagnosing Turner syndrome...
2017: SAGE open medical case reports
https://www.readbyqxmd.com/read/28228413/determination-of-human-hepatic-cyp2c8-and-cyp1a2-age-dependent-expression-to-support-human-health-risk-assessment-for-early-ages
#7
Gina Song, Xueying Sun, Ronald N Hines, D Gail McCarver, Brian G Lake, Thomas G Osimitz, Moire R Creek, Harvey J Clewell, Miyoung Yoon
Predicting age-specific metabolism is important for evaluating age-related drug and chemical sensitivity. Multiple cytochrome P450s (CYP) and carboxylesterase (CES) enzymes are responsible for human pyrethroid metabolism. Complete ontogeny data for each enzyme is needed to support in vitro to in vivo extrapolation (IVIVE). This study was designed to determine age-dependent human hepatic CYP2C8 expression, for which only limited ontogeny data are available, and to further define CYP1A2 ontogeny. CYP2C8 and 1A2 protein levels were measured by quantitative Western blotting using liver microsomal samples prepared from 222 subjects with ages ranging from 8 weeks gestation to 18 years after birth...
February 22, 2017: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/28225798/effect-of-maternal-death-on-child-survival-in-rural-west-africa-25-years-of-prospective-surveillance-data-in-the-gambia
#8
Susana Scott, Lindsay Kendall, Pierre Gomez, Stephen R C Howie, Syed M A Zaman, Samba Ceesay, Umberto D'Alessandro, Momodou Jasseh
BACKGROUND: The death of a mother is a tragedy in itself but it can also have devastating effects for the survival of her children. We aim to explore the impact of a mother's death on child survival in rural Gambia, West Africa. METHODS: We used 25 years of prospective surveillance data from the Farafenni Health and Demographic surveillance system (FHDSS). Mortality rates per 1,000 child-years up to ten years of age were estimated and Kaplan-Meier survival curves plotted by maternal vital status...
2017: PloS One
https://www.readbyqxmd.com/read/28224426/nutritional-status-of-under-five-children-from-urban-low-income-families-in-xiangtan-and-jilin-in-china
#9
Yan-Fang Guo, Yin-Yan Gan, Chao-Nan Guo, Ju Sun, Li-Ping Hao
There have been many studies on the nutrition and the growth status of children from rural and remote western regions of China, whereas researches on children from urban low-income families are scarce. This study aimed to investigate the growth and nutritional status of children under five years of age from urban low-income families in China. There were 169 children aged 25-60 months recruited from Xiangtan and Jilin, two cities with a population of 2.81 million and 4.26 million respectively, in China in this cluster cross-sectional study...
February 2017: Journal of Huazhong University of Science and Technology. Medical Sciences
https://www.readbyqxmd.com/read/28222694/knowledge-of-obstetric-danger-signs-and-associated-factors-among-reproductive-age-women-in-raya-kobo-district-of-ethiopia-a-community-based-cross-sectional-study
#10
Nigus Bililign, Tesfahun Mulatu
BACKGROUND: Knowledge of danger signs of obstetric complications during pregnancy, labour, and postnatal period is the first essential step for appropriate and timely referral. This study aimed to investigate predictors of knowledge about obstetric danger signs during pregnancy, delivery, and postpartum period among mothers of reproductive age women who gave birth in the last 12 months. METHODS: A quantitative community based cross-sectional study was employed during March 2016...
February 21, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28222529/progressive-motor-deficit-is-mediated-by-the-denervation-of-neuromuscular-junctions-and-axonal-degeneration-in-transgenic-mice-expressing-mutant-p301s-tau-protein
#11
Zhuoran Yin, Femke Valkenburg, Betty E Hornix, Ietje Mantingh-Otter, Xingdong Zhou, Muriel Mari, Fulvio Reggiori, Debby Van Dam, Bart J L Eggen, Peter P De Deyn, Erik Boddeke
Tauopathies include a variety of neurodegenerative diseases associated with the pathological aggregation of hyperphosphorylated tau, resulting in progressive cognitive decline and motor impairment. The underlying mechanism for motor deficits related to tauopathy is not yet fully understood. Here, we use a novel transgenic tau mouse line, Tau 58/4, with enhanced neuron-specific expression of P301S mutant tau to investigate the motor abnormalities in association with the peripheral nervous system. Using stationary beam, gait, and rotarod tests, motor deficits were found in Tau 58/4 mice already 3 months after birth, which deteriorated during aging...
February 10, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28222232/dietary-total-antioxidant-capacity-in-early-school-age-and-subsequent-allergic-disease
#12
Anna Gref, Susanne Rautiainen, Olena Gruzieva, Niclas Håkansson, Inger Kull, Göran Pershagen, Magnus Wickman, Alicja Wolk, Erik Melén, Anna Bergström
BACKGROUND: Dietary antioxidant intake has been hypothesized to influence the development of allergic diseases, however, few prospective studies have investigated this association. OBJECTIVE: Our aim was to study the association between total antioxidant capacity (TAC) of the diet at age 8 years and the subsequent development of asthma, rhinitis and sensitization to inhalant allergens between 8 and 16 years, and to assess potential effect modification by known risk factors...
February 21, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28222195/autoantibodies-against-mono-and-tri-methylated-lysine-display-similar-but-also-distinctive-characteristics
#13
Zhiqiang Wang, Younan Ma, Fan Liu, Linjie Chen, Ruitong Gao, Wei Zhang
Autoantibodies can be either harmful or beneficial to the body. The beneficial autoantibodies play important roles in immunosurveillance, clearance of body waste and maintenance of immune homeostasis. Despite their importance, however, people's knowledge on the protective autoantibodies is still very limited. In the current study, we examined two autoantibodies that recognized epitopes with only one amino acid. One was against mono-methylated lysine (Kme) and the other was against tri-methylated lysine (Kme3)...
2017: PloS One
https://www.readbyqxmd.com/read/28220408/guanidinoacetate-methyltransferase-activity-in-lymphocytes-for-a-fast-diagnosis
#14
Lisette M Berends, Eduard A Struys, Birthe Roos, Ulbe Holwerda, Erwin E W Jansen, Gajja S Salomons, Mirjam M C Wamelink
INTRODUCTION: Guanidinoacetate methyltransferase (GAMT) deficiency is an inborn error of metabolism (IEM), clinically characterized by intellectual disability, developmental delay, seizures, and movement disorders. Biochemical diagnosis of GAMT deficiency is based on the measurement of creatine and guanidinoacetate in urine, plasma, or CSF and is confirmed genetically by DNA analysis or by enzyme assay in lymphoblasts or fibroblasts. To obtain enough cells, these cells need to be cultured for at least 1 month...
February 21, 2017: JIMD Reports
https://www.readbyqxmd.com/read/28220257/impact-of-prior-breast-cancer-on-mode-of-delivery-and-pregnancy-associated-disorders-a-retrospective-analysis-of-subsequent-pregnancy-outcomes
#15
Louis Jacob, Matthias Kalder, Birgit Arabin, Karel Kostev
PURPOSE: The aim of this paper is to analyze the impact of prior breast cancer (BC) on mode of delivery and pregnancy-associated disorders. METHODS: A database from 262 German gynecological practices including 289,712 women between the ages of 18 and 45 with documented pregnancies between 2000 and 2014 was used to search for patients with a history of BC up to 10 years prior to pregnancy. A total of 165 patients with a history of BC were found and matched with 165 patients without a history of any cancer (1:1) by age, physician, obesity, and documented referral to a fertility center up to 12 months before the index pregnancy...
February 20, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28219911/triple-negative-breast-cancer-with-brain-metastasis-in-a-pregnant-woman
#16
Francisco Trinca, Mariana Inácio, Teresa Timóteo, Rui Dinis
A woman aged 35 years was diagnosed with triple-negative breast cancer in October 2012. During the investigation, it was discovered that she was pregnant, the patient decided to have an abortion. She was submitted to a radical modified mastectomy and adjuvant chemotherapy followed by adjuvant breast radiotherapy of the left breast. 2 months after the adjuvant treatment, she began to have headaches and dizziness. The cranial MRI (head MRI) showed brain metastasis. She was then treated with whole brain radiotherapy, stereotactic radiosurgery and concomitant temozolomide which resulted in complete response...
February 20, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28219420/umbilical-cord-care-practices-in-low-and-middle-income-countries-a-systematic-review
#17
Patricia S Coffey, Siobhan C Brown
BACKGROUND: Neonatal sepsis is the third leading cause of deaths for infants in their first month of life. The newly cut umbilical cord can be a pathway for bacteria that can cause newborn sepsis and death. Optimal umbilical cord care practices for newborns and during the first week of life, especially in settings with poor hygiene, has the potential to avoid these preventable neonatal deaths. The purpose of this review of cord care practices is to assist in the development of behavior-change strategies to support introduction of novel cord-care regimens, particularly 7...
February 20, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28219408/the-impact-of-post-operative-sepsis-on-mortality-after-hospital-discharge-among-elective-surgical-patients-a-population-based-cohort-study
#18
Lixin Ou, Jack Chen, Ken Hillman, Arthas Flabouris, Michael Parr, Hassan Assareh, Rinaldo Bellomo
BACKGROUND: Our aim in the present study was to assess the mortality impact of hospital-acquired post-operative sepsis up to 1 year after hospital discharge among adult non-short-stay elective surgical patients. METHODS: We conducted a population-based, retrospective cohort study of all elective surgical patients admitted to 82 public acute hospitals between 1 January 2007 and 31 December 2012 in New South Wales, Australia. All adult elective surgical admission patients who stayed in hospital for ≥4 days and survived to discharge after post-operative sepsis were identified using the Admitted Patient Data Collection records linked with the Registry of Births, Deaths, and Marriages...
February 20, 2017: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/28219157/-long-term-effect-of-iodine-deficiency-on-growth-and-food-utilization-rate-in-second-filial-generation-rats
#19
Ainiwaer Muyeseer, G X Zhang, J Wang, Y Liu, X H Meng, Q Liu
Objective: To study the effect of iodine deficiency on body weight, food consumption, and food utilization rate of second filial generation Wistar rats. Methods: According to the food pattern of a high-iodine deficient population, two types of low-iodine food have been produced using the main crops grown in this area (iodine levels of 50 and 20 μg/kg, respectively). Wistar rats were randomly divided into three groups, normal iodine group (NI group), low-iodine group one (LI group) and low-iodine group two (LII group), using the random number table method and fed diets containing 300, 50, and 20 μg/kg of iodine, respectively...
February 6, 2017: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/28218559/a-scandcleft-randomised-trials-of-primary-surgery-for-unilateral-cleft-lip-and-palate-1-planning-and-management
#20
Gunvor Semb, Hans Enemark, Hans Friede, Gunnar Paulin, Jan Lilja, Jorma Rautio, Mikael Andersen, Frank Åbyholm, Anette Lohmander, William Shaw, Kirsten Mølsted, Arja Heliövaara, Stig Bolund, Jyri Hukki, Hallvard Vindenes, Peter Davenport, Kjartan Arctander, Ola Larson, Anders Berggren, David Whitby, Alan Leonard, Erik Neovius, Anna Elander, Elisabeth Willadsen, R Patricia Bannister, Eileen Bradbury, Gunilla Henningsson, Christina Persson, Philip Eyres, Berit Emborg, Mia Kisling-Møller, Annelise Küseler, Birthe Granhof Black, Antje Schöps, Anja Bau, Maria Boers, Helene Søgaard Andersen, Karin Jeppesen, Dorte Marxen, Marjukka Paaso, Elina Hölttä, Suvi Alaluusua, Leena Turunen, Kirsti Humerinta, Ulla Elfving-Little, Inger Beate Tørdal, Lillian Kjøll, Ragnhild Aukner, Øydis Hide, Kristin Billaud Feragen, Elisabeth Rønning, Pål Skaare, Eli Brinck, Ann-Magritt Semmingsen, Nina Lindberg, Melanie Bowden, Julie Davies, Jeanette Mooney, Haydn Bellardie, Nina Schofield, Jill Nyberg, Maria Lundberg, Agneta Linder-Aronson Karsten, Margareta Larson, Anders Holmefjord, Sigvor Reisæter, Nina-Helen Pedersen, Therese Rasmussen, Rolf Tindlund, Paul Sæle, Reidunn Blomhoff, Gry Jacobsen, Christina Havstam, Sara Rizell, Lars Enocson, Catharina Hagberg, Midia Najar Chalien, Anna Paganini, Inger Lundeborg, Agneta Marcusson, Anna-Britta Mjönes, Annica Gustavsson, Christine Hayden, Eilish McAleer, Emma Slevan, Terry Gregg, Helen Worthington
BACKGROUND AND AIMS: Longstanding uncertainty surrounds the selection of surgical protocols for the closure of unilateral cleft lip and palate, and randomised trials have only rarely been performed. This paper is an introduction to three randomised trials of primary surgery for children born with complete unilateral cleft lip and palate (UCLP). It presents the protocol developed for the trials in CONSORT format, and describes the management structure that was developed to achieve the long-term engagement and commitment required to complete the project...
February 2017: Journal of Plastic Surgery and Hand Surgery
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