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https://www.readbyqxmd.com/read/29409204/correction-of-ankle-and-hind-foot-deformity-in-charcot-neuroarthropathy-using-a-retrograde-hind-foot-nail-the-kings-experience
#1
N Vasukutty, H Jawalkar, A Anugraha, R Chekuri, R Ahluwalia, V Kavarthapu
BACKGROUND: Corrective fusion for the unstable deformed hind foot and mid foot in Charcot Neuroarthropathy (CN) is quite challenging and is best done in tertiary centres under the supervision of multidisciplinary teams. METHODS: We present a follow up to our initial report with a series of 42 hind foot corrections in 40 patients from a tertiary level teaching hospital in the United Kingdom. The mean patient age was 59 (33-82). 17 patients had type1diabetes mellitus, 23 had type 2...
April 28, 2017: Foot and Ankle Surgery: Official Journal of the European Society of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/15225764/cyp27b1-polymorphisms-variants-are-associated-with-type-1-diabetes-mellitus-in-germans
#2
Elizabeth Ramos Lopez, Karoline Regulla, Michael A Pani, Maren Krause, Klaus-H Usadel, Klaus Badenhoop
CYP27B1 (25-hydroxyvitamin D(3)-1alpha-hydroxylase) catalyzes the metabolization of 25-hydroxyvitamin D(3) to 1,25(OH)(2)D(3) the most active natural Vitamin D metabolite. 1,25(OH)(2)D(3) plays a role in the regulation of autoimmunity and cell proliferation and prevents the development of autoimmune diabetes mellitus in animal models besides other autoimmune disorders. One hundred and eighty-seven families with one offspring affected with type1diabetes mellitus were genotyped for the polymorphisms in the promoter region (-1260 C/A) and intron 6 (2338 T/C) of the CYP27B1 gene on chromosome 12 q13...
May 2004: Journal of Steroid Biochemistry and Molecular Biology
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