Srividya Velagapudi, Gergely Karsai, Maria Karsai, Shafeeq A Mohammed, Fabrizio Montecucco, Luca Liberale, Hwan Lee, Federico Carbone, Giovanni Francesco Adami, Kangmin Yang, Margot Crucet, Sokrates Stein, Franceso Paneni, Tetiana Lapikova-Bryhinska, Hyun-Duk Jang, Simon Kraler, Daria Vdovenko, Richard Arnold Züllig, Giovanni G Camici, Hyo-Soo Kim, Reijo Laaksonen, Philipp A Gerber, Thorsten Hornemann, Alexander Akhmedov, Thomas F Lüscher
BACKGROUND: Obesity and type 2 diabetes (T2D) are major risk factors for cardiovascular diseases (CVD). Dysregulated pro-apoptotic ceramide synthesis reduces β-cell insulin secretion, thereby promoting hyperglycemic states which may manifest as T2D. Pro-apoptotic ceramides modulate insulin sensitivity and glucose tolerance while being linked to poor cardiovascular outcomes. Sirtuin-1 (SIRT1) is a NAD + - dependent deacetylase that protects against pancreatic β-cell dysfunction; however, systemic levels are decreased in obese T2D mice and may promote pro-apoptotic ceramide synthesis and hyperglycemia...
May 13, 2024: Cardiovascular Research