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Adolescent osteoporosis

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https://www.readbyqxmd.com/read/29783019/total-flavonoid-extract-of-epimedium-herb-increases-the-peak-bone-mass-of-young-rats-involving-enhanced-activation-of-the-ac10-camp-pka-creb-pathway
#1
Hui-Rong Xi, Hui-Ping Ma, Fang-Fang Yang, Yu-Hai Gao, Jian Zhou, Yuan-Yuan Wang, Wen-Yuan Li, Cory J Xian, Ke-Ming Chen
ETHNOPHARMACOLOGICAL RELEVANCE: Epimedium sagittatum brevicornum Maxim. is an important traditional Chinese herb that has long been used to promote bone fracture healing and treat osteoporosis. AIM OF THE STUDY: Achieving peak bone mass by adolescence has now been accepted to be fundamental for preventing osteoporosis in adulthood life. This study investigated the possibility of increasing peak bone mass in young rats using the total flavonoid extract of Epimedium herb (TFE)...
May 18, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29710770/exercise-early-and-often-effects-of-physical-activity-and-exercise-on-women-s-bone-health
#2
REVIEW
Karen L Troy, Megan E Mancuso, Tiffiny A Butler, Joshua E Johnson
In 2011 over 1.7 million people were hospitalized because of a fragility fracture, and direct costs associated with osteoporosis treatment exceeded 70 billion dollars in the United States. Failure to reach and maintain optimal peak bone mass during adulthood is a critical factor in determining fragility fracture risk later in life. Physical activity is a widely accessible, low cost, and highly modifiable contributor to bone health. Exercise is especially effective during adolescence, a time period when nearly 50% of peak adult bone mass is gained...
April 28, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29698804/phenotype-variability-in-hajdu-cheney-syndrome
#3
Miriam Regev, Ben Pode-Shakked, Jeffrey M Jacobson, Annick Raas-Rothschild, David B Goldstein, Yair Anikster
Hajdu Cheney syndrome is a rare autosomal dominant skeletal dysplasia, with multi-organ involvement, caused by pathogenic variants in NOTCH2. It is characterized by progressive focal bone destruction, including acro-osteolysis and generalized osteoporosis, craniofacial anomalies, hearing loss, cardiovascular involvement and polycystic kidneys. Distinct radiographic findings, such as a serpentine fibula, may aid in facilitating the diagnosis. Despite several dozens of cases described in the literature, diagnosis often remains elusive, resulting in many cases in a delay in diagnosis reaching adolescence or adulthood...
April 23, 2018: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/29696750/angelman-syndrome-in-adolescence-and-adulthood-a-retrospective-chart-review-of-53-cases
#4
Ankita Prasad, Olivia Grocott, Kimberly Parkin, Anna Larson, Ronald L Thibert
Angelman syndrome is a neurogenetic disorder with varying clinical presentations and symptoms as the individual ages. The goal of this study was to characterize changes over time in the natural history of this syndrome in a large population. We reviewed the medical records of the 53 patients who were born prior to 2000 and seen at the Angelman Syndrome Clinic at Massachusetts General Hospital to assess neurological, sleep, behavioral, gastrointestinal, orthopedic, and ophthalmologic functioning. The average age of this cohort was 24 years...
April 25, 2018: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/29658144/bone-fragility-in-turner-syndrome-fracture-prevalence-and-risk-factors-determined-by-a-national-patient-survey
#5
Halley Wasserman, Philippe F Backeljauw, Jane C Khoury, Heidi J Kalkwarf, Catherine M Gordon
OBJECTIVE: Osteoporosis is considered a comorbidity of adult women with Turner Syndrome (TS). Limited data are available on fracture prevalence in girls and women with this diagnosis. We aimed to determine the prevalence of fractures in individuals with TS in the United States and identify risk factors for fracture. DESIGN: Girls and women with TS were invited to participate in an anonymous, self-report, national survey from November 2016 to March 2017. Non-TS controls were obtained through direct contacts of TS participants...
April 15, 2018: Clinical Endocrinology
https://www.readbyqxmd.com/read/29657025/physical-fitness-adiposity-and-diets-as-surrogate-measures-of-bone-health-in-schoolchildren-a-biochemical-and-cross-sectional-survey-analysis
#6
Ahmad H Alghadir, Sami A Gabr, Ashraf A Rizk
This study aimed to investigate the associations between adiposity, muscular fitness (MF), diet, sun exposure, and physical activity profiles as surrogate measures with bone health status in a sample of schoolchildren aged 8-18 yr old. A total of 250 Egyptian schoolchildren aged 8-18 yr were randomly invited to participate in these cross-sectional survey analyses. Calcaneal broadband ultrasound attenuation (c-BUA), bone mineral density (BMD), and bone formation markers (total calcium, serum bone alkaline phosphatase, and osteocalcin) were measured as markers of bone health...
March 21, 2018: Journal of Clinical Densitometry
https://www.readbyqxmd.com/read/29626614/effects-of-whole-body-vibration-on-tibia-strength-and-structure-of-competitive-adolescent-swimmers-a-randomized-controlled-trial
#7
Alejandro Gómez-Bruton, Alejandro González-Agüero, Angel Matute-Llorente, Cristina Julián, Gabriel Lozano-Berges, Alba Gómez-Cabello, Nuria Garatachea, Jose A Casajús, German Vicente-Rodríguez
BACKGROUND: Swimming has no effect on bone mass or structure. Therefore, adolescent swimmers present similar bone strength values when compared to normo-active controls, and lower values when compared to weight-bearing athletes. It thus seems necessary to try to improve bone structure and strength of adolescent swimmers through a weight-bearing intervention in order to reduce the risk of suffering osteoporosis later in life. OBJECTIVE: To evaluate the effects of a 6-month WBV intervention on bone strength and structure of adolescent swimmers...
April 4, 2018: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/29594644/non-osteogenic-muscle-hypertrophy-in-children-with-mcardle-disease
#8
I Rodríguez-Gómez, A Santalla, J Díez-Bermejo, D Munguía-Izquierdo, L M Alegre, G Nogales-Gadea, J Arenas, M A Martín, A Lucía, I Ara
INTRODUCTION: McArdle disease is an inborn disorder of muscle glycogen metabolism that produces exercise intolerance, and has been recently associated with low values ​​of lean mass (LM) and bone mineral content (BMC) and density (BMD) in affected adults. Here we aimed to study whether this bone health problem begins in childhood. METHODS: Forty children and adolescents were evaluated: 10 McArdle disease and 30 control children (mean age of both groups, 13 ± 2y)...
March 28, 2018: Journal of Inherited Metabolic Disease
https://www.readbyqxmd.com/read/29564304/track-and-field-practice-and-bone-outcomes-among-adolescents-a-pilot-study-abcd-growth-study
#9
Yuri da Silva Ventura Faustino-da-Silva, Ricardo Ribeiro Agostinete, André Oliveira Werneck, Santiago Maillane-Vanegas, Kyle Robinson Lynch, Isabella Neto Exupério, Igor Hideki Ito, Romulo Araújo Fernandes
Background: Osteoporosis is considered a public health problem with high worldwide prevalence. One approach to prevention is through the promotion of physical activity, especially exercise, during adolescence. Methods: This study compared bone variables in different body segments in adolescents according to participation in track and field. The study included 34 adolescents (22 boys), of whom 17 were track and field athletes and 17 were control subjects. Bone mineral density (BMD, g/cm2 ) and bone mineral content (BMC, g) were analyzed using dual energy X-ray absorptiometry (total body stratified by body segments)...
February 2018: Journal of Bone Metabolism
https://www.readbyqxmd.com/read/29504223/consensus-guidelines-on-the-use-of-bisphosphonate-therapy-in-children-and-adolescents
#10
Peter J Simm, Andrew Biggin, Margaret R Zacharin, Christine P Rodda, Elaine Tham, Aris Siafarikas, Craig Jefferies, Paul L Hofman, Diane E Jensen, Helen Woodhead, Justin Brown, Benjamin J Wheeler, Denise Brookes, Antony Lafferty, Craig F Munns
Bisphosphonate therapy is the mainstay of pharmacological intervention in young people with skeletal fragility. The evidence of its use in a variety of conditions remains limited despite over three decades of clinical experience. On behalf of the Australasian Paediatric Endocrine Group, this evidence-based consensus guideline presents recommendations and discusses the graded evidence (using the GRADE system) for these recommendations. Primary bone fragility disorders such as osteogenesis imperfecta are considered separately from osteoporosis secondary to other clinical conditions (such as cerebral palsy, Duchenne muscular dystrophy)...
March 2018: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/29504042/bone-mineral-density-and-nutritional-status-in-children-with-quadriplegic-cerebral-palsy
#11
Citlalli Alvarez Zaragoza, Edgar Manuel Vasquez Garibay, Andrea A García Contreras, Alfredo Larrosa Haro, Enrique Romero Velarde, Alejandro Rea Rosas, José Luis Cabrales de Anda, Israel Vega Olea
This study demonstrated the relationship of low bone mineral density (BMD) with the degree of motor impairment, method of feeding, anthropometric indicators, and malnutrition in children with quadriplegic cerebral palsy (CP). The control of these factors could optimize adequate bone mineralization, avoid the risk of osteoporosis, and would improve the quality of life. PURPOSE: The purpose of the study is to explore the relationship between low BMD and nutritional status in children with quadriplegic CP...
March 4, 2018: Archives of Osteoporosis
https://www.readbyqxmd.com/read/29503055/vitamin-d-nutritional-status-and-bone-turnover-markers-in-childhood-acute-lymphoblastic-leukemia-survivors-a-petale-study
#12
E Delvin, N Alos, F Rauch, V Marcil, S Morel, M Boisvert, M-A Lecours, C Laverdière, D Sinnett, M Krajinovic, J Dubois, S Drouin, G Lefebvre, M Samoilenko, C Nyalendo, E Cavalier, E Levy
BACKGROUND: The remarkable progress in the treatment of childhood acute lymphoblastic leukemia (cALL) has led to a survival rate reaching 90%. This success story is unfortunately linked to increased risk of impaired skeletal mass accumulation during childhood and adolescence, predisposing the patients to osteoporosis and pathological fractures at adulthood. OBJECTIVE: This study aims at characterizing the vitamin D status and bone health biomarkers in a well-characterized cohort of cALL survivors...
February 21, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29490662/vegetarian-style-dietary-pattern-during-adolescence-has-long-term-positive-impact-on-bone-from-adolescence-to-young-adulthood-a-longitudinal-study
#13
Elham Z Movassagh, Adam D G Baxter-Jones, Saija Kontulainen, Susan Whiting, Michael Szafron, Hassan Vatanparast
BACKGROUND: The amount of bone accrued during adolescence is an important determinant of later osteoporosis risk. Little is known about the influence of dietary patterns (DPs) on the bone during adolescence and their potential long-term implications into adulthood. We examined the role of adolescent DPs on adolescent and young adult bone and change in DPs from adolescence to young adulthood. METHODS: We recruited participants from the Saskatchewan Pediatric Bone Mineral Accrual Study (1991-2011)...
February 28, 2018: Nutrition Journal
https://www.readbyqxmd.com/read/29461563/external-skeletal-robusticity-of-children-and-adolescents-european-references-from-birth-to-adulthood-and-international-comparisons
#14
Rebekka Mumm, Elena Godina, Slawomir Koziel, Martin Musalek, Petr Sedlak, Ursula Wittwer-Backofen, Volker Hesse, Parasmani Dasgupta, Maciej Henneberg, Christiane Scheffler
Background: In our modern world, the way of life in nutritional and activity behaviour has changed. As a consequence, parallel trends of an epidemic of overweight and a decline in external skeletal robusticity are observed in children and adolescents. Aim: We aim to develop reference centiles for external skeletal robusticity of European girls and boys aged 0 to 18 years using the Frame Index as an indicator and identify population specific age-related patterns. Methods: We analysed cross-sectional & longitudinal data on body height and elbow breadth of boys and girls from Europe (0-18 years, n = 41...
February 20, 2018: Anthropologischer Anzeiger; Bericht über die Biologisch-anthropologische Literatur
https://www.readbyqxmd.com/read/29413740/bone-mineral-density-after-spinal-fusion-surgery-for-adolescent-idiopathic-scoliosis-at-a-minimum-20-year-follow-up
#15
Masayuki Ohashi, Toru Hirano, Kei Watanabe, Keiichi Katsumi, Hirokazu Shoji, Tatsuki Mizouchi, Naoto Endo
STUDY DESIGN: A retrospective, long-term follow-up study. OBJECTIVE: We investigated the incidence and risk factors for osteopenia at a minimum of 20 years after spinal instrumented fusion for adolescent idiopathic scoliosis (AIS). SUMMARY OF BACKGROUND DATA: Surgically treated AIS patients may be likely to have osteopenia in adulthood because the association between AIS and osteopenia has been well documented. However, the long-term results of AIS surgery on BMD have not been evaluated...
March 2018: Spine Deformity
https://www.readbyqxmd.com/read/29411454/sex-specific-patterns-in-cortical-and-trabecular-bone-microstructure-in-the-kirsten-skeletal-collection-south-africa
#16
Amy C Beresheim, Susan K Pfeiffer, Marc D Grynpas, Amanda Alblas
OBJECTIVES: The purpose of this study was to provide bone histomorphometric reference data for South Africans of the Western Cape who likely dealt with health issues under the apartheid regime. METHODS: The 206 adult individuals (n female = 75, n male = 131, mean = 47.9 ± 15.8 years) from the Kirsten Skeletal Collection, U. Stellenbosch, lived in the Cape Town metropole from the late 1960s to the mid-1990s. To study age-related changes in cortical and trabecular bone microstructure, photomontages of mid-thoracic rib cross-sections were quantitatively examined...
February 7, 2018: American Journal of Human Biology: the Official Journal of the Human Biology Council
https://www.readbyqxmd.com/read/29367750/methylphenidate-regulation-of-osteoclasts-in-a-dose-and-sex-dependent-manner-adversely-affects-skeletal-mechanical-integrity
#17
Sardar M Z Uddin, Lisa S Robison, Dennis Fricke, Evan Chernoff, Michael Hadjiargyrou, Panayotis K Thanos, David E Komatsu
Methylphenidate (MP) is the most prescribed psychostimulant for ADHD patients, with clinically demonstrated detrimental effects on bone quality, potentially leading to early onset osteoporosis and higher fracture risk. The underlying mechanism for the effects of MP on bone remains elusive. This study demonstrates that sex- and dose-dependent effects of MP on bone quality and quantity are mediated by osteoclast activity. Four-week-old male and female rats were treated with low and high dose MP for 13 weeks. Bone quality and quantity were analyzed using microCT, mechanical testing, histomorphometry, and TRAP staining...
January 24, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29362271/does-vitamin-d-supplementation-improve-bone-density-in-vitamin-d-deficient-children-protocol-for-an-individual-patient-data-meta-analysis
#18
Tania Winzenberg, Christel Lamberg-Allardt, Ghada El-Hajj Fuleihan, Christian Mølgaard, Kun Zhu, Feitong Wu, Richard D Riley
INTRODUCTION: Our previous study-level (aggregate data) meta-analysis suggested that vitamin D supplements may be beneficial for bone density specifically in children with vitamin D deficiency. However, the misclassification of vitamin D status inherent in study-level data means that the results are not definitive and cannot provide an accurate assessment of the size of any effect. Therefore, we propose to undertake an individual patient data (IPD) meta-analysis to determine whether the effect of vitamin D supplementation on bone density in children differs according to baseline vitamin D status, and to specifically estimate the effect of vitamin D in children who are vitamin D deficient...
January 23, 2018: BMJ Open
https://www.readbyqxmd.com/read/29316107/development-and-feasibility-of-mandarin-language-bone-health-scales-for-adolescents-with-cancer-in-taiwan
#19
Wei-Wen Wu, Chieh-Yu Liu, Shiann-Tarng Jou, Giun-Yi Hung, Shu-Yuan Liang
Cancer during adolescence increases the risk for bone mass deficiency later in life. Adolescents with cancer must learn to improve their bone health to avoid osteoporosis. In the present cross-sectional study, we developed and tested scales to assess the bone health self-efficacy and beliefs of adolescents with cancer in Taiwan. Test development followed three stages: item generation and scale formatting, examination of content validity, and validation of psychometric properties with a sample of 100 adolescents with cancer...
January 8, 2018: Nursing & Health Sciences
https://www.readbyqxmd.com/read/29280666/-bone-metabolism-in-child-and-adolescent-athletes-a-systematic-review
#20
Marta Rapún López, Hugo Olmedillas, Francisco Pradas de la Fuente, Alba Gómez-Cabello, Alejandro González-Agüero, José Antonio Casajús, Germán Vicente-Rodríguez
BACKGROUND: Physical exercise is beneficial for the prevention of osteoporosis. Bone metabolism markers are the main indicators of metabolic balance and may indicate early risk in bone tissue. AIM: This systematic review aims to summarize and update present knowledge about bone metabolism markers in child and adolescent athletes. METHOD: Literature search was conducted up to March 2017 in PubMed and Sport Discus. A total of 19 studies (case-control, longitudinal and randomized control trials) met the inclusion criteria and were included in the review...
November 16, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
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