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https://www.readbyqxmd.com/read/29733063/adrenergic-signaling-molecular-complexes
#1
Rocío Alcántara-Hernández, Aurelio Hernández-Méndez
Adrenaline and noradrenaline bind to membrane receptors of the superfamily of G protein-coupled receptors (GPCR) in target cells, where they modulate physiological responses such as metabolism, vasoconstriction, vasodilation and proliferation. Alteration in their function is associated with conditions such as hypertension, benign prostatic hyperplasia and cardiac hypertrophy. In response to adrenaline, receptors form signaling complexes, which enables adrenergic action to be specific, rapid and efficient. These signaling complexes or signalosomes are composed of kinases, phosphatases, and adapter and scaffold proteins, which together modulate the receptor function...
2018: Gaceta Médica de México
https://www.readbyqxmd.com/read/29621721/interventions-and-controls-to-prevent-emergency-service-vehicle-incidents-a-mixed-methods-review
#2
David P Bui, Samantha Balland, Casey Giblin, Alesia Jung, Sandy Kramer, Abigail Peng, Marie Corazon Ponce Aquino, Stephanie Griffin, Dustin D French, Keshia Pollack Porter, Steve Crothers, Jefferey L Burgess
BACKGROUND: Emergency service vehicle incidents (ESVI), including crashes, rollovers, and roadside struck-by-incidents, are a leading cause of occupational fatality and injury among firefighters and other emergency responders. Though there are numerous strategies and interventions to prevent ESVIs, the evidence base for these strategies is limited and dispersed. The goal of this study was to gather and present a review of evidence-based ESVI interventions. METHODS: We searched five academic databases for articles published within the last decade featuring interventions to reduce or prevent ESVIs...
April 2, 2018: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/29429035/inhibitory-effect-of-the-green-tea-molecule-egcg-against-dengue-virus-infection
#3
Muhareva Raekiansyah, Corazon C Buerano, Mark Anthony D Luz, Kouichi Morita
Dengue virus (DENV) infection is a major public health problem worldwide; however, specific antiviral drugs against it are not available. Hence, identifying effective antiviral agents for the prevention of DENV infection is important. In this study, we showed that the reportedly highly biologically active green-tea component epigallocatechin gallate (EGCG) inhibited dengue virus infection regardless of infecting serotype, but no or minimal inhibition was observed with other flaviviruses, including Japanese encephalitis virus, yellow fever virus, and Zika virus...
February 10, 2018: Archives of Virology
https://www.readbyqxmd.com/read/29409678/isolation-and-genomic-characterization-of-culex-flaviviruses-from-mosquitoes-in-myanmar
#4
Aung Kyaw Kyaw, Mya Myat Ngwe Tun, Corazon C Buerano, Takeshi Nabeshima, Miako Sakaguchi, Tsuyoshi Ando, Shingo Inoue, Yi Yi Mya, Daisuke Hayasaka, Hlaing Myat Thu, Kyaw Zin Thant, Kouichi Morita
An entomological surveillance of arboviruses was conducted in Myanmar in 2014. A total of 8357 Culex mosquito vectors were collected in the Mandalay area and virus isolation was done by using the mosquito cell line C6/36 E2. A total of eighteen strains of Culex flavivirus (CxFV) were isolated from Cx. tritaeniorhynchus, Cx. vishnui and Cx. fuscocephala. Like other insect-specific flaviviruses, CxFV can replicate only in mosquito cells but not in mammalian cells. These CxFV strains that were isolated in Japan from mosquitoes collected in Myanmar were closely related to the Wang Thong virus detected from Cx fusocephalus in Thailand and Cx...
March 2, 2018: Virus Research
https://www.readbyqxmd.com/read/29374786/metal-free-salan-type-compound-induces-apoptosis-and-overcomes-multidrug-resistance-in-leukemic-and-lymphoma-cells-in-vitro
#5
Maxim Dragoun, Thomas Günther, Corazon Frias, Albrecht Berkessel, Aram Prokop
PURPOSE: We report on our preclinical findings of a simple salicylic diamine compound (THG 1213) which has yielded exceptional results as a potential chemotherapeutic drug. THG 1213 is an easy to synthesize chiral and metal-free salan compound. METHODS: THG 1213 was tested on several leukemia, lymphoma and solid tumor cell lines in vitro. The effects have been studied by LDH release essay, FACS flow cytometry, photometric cell count, immunoblotting, and NMR spectroscopy...
April 2018: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/29363460/detection-of-zika-virus-infection-in-myanmar
#6
Mya Myat Ngwe Tun, Aung Kyaw Kyaw, Saw Wut Hmone, Shingo Inoue, Corazon C Buerano, Aung Min Soe, Meng Ling Moi, Daisuke Hayasaka, Hlaing Myat Thu, Futoshi Hasebe, Kyaw Zin Thant, Kouichi Morita
Zika virus (ZIKV), an emerging mosquito-borne flavivirus, causes a dengue-like infection that has recently caught global attention. The infection, which also includes some birth defects, has been documented in the Americas, Pacific Islands, and some parts of Africa and Asia. There are no published reports on local ZIKV transmission in Myanmar. In this study, a total of 462 serum samples from patients and asymptomatic persons were collected in Myanmar from 2004 to 2017. They were analyzed for ZIKV infection by immunoglobulin M capture enzyme-linked immunosorbent assay (ELISA), immunoglobulin G indirect ELISA, neutralization test, real-time polymerase chain reaction (PCR), and conventional PCR...
March 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29342952/a-long-term-follow-up-of-the-efficacy-of-nature-based-therapy-for-adults-suffering-from-stress-related-illnesses-on-levels-of-healthcare-consumption-and-sick-leave-absence-a-randomized-controlled-trial
#7
Sus Sola Corazon, Patrik Karlsson Nyed, Ulrik Sidenius, Dorthe Varning Poulsen, Ulrika Karlsson Stigsdotter
Stress-related illnesses are a growing health problem in the Western world; which also has economic significance for society. As a consequence; there is a growing demand for effective treatments. The study investigates the long-term efficacy of the Nacadia® nature-based therapy (NNBT) by comparing it to the efficacy of a validated cognitive behavioral therapy, called STreSS. The study is designed as a randomized controlled trial in which 84 participants are randomly allocated between the treatments. Long-term efficacy is investigated through data extracts from the national database of Statistics Denmark on the sick leave and the health-care consumption...
January 15, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29323410/housing-first-and-photovoice-transforming-lives-communities-and-systems
#8
Anna S Pruitt, John P Barile, Terry Yasuko Ogawa, Nelson Peralta, Reumell Bugg, John Lau, Thomas Lamberton, Corazon Hall, Victor Mori
This article presents findings from a community-based participatory evaluation of a Housing First program on the Island of O'ahu. In this study, clients in a Housing First program used Photovoice to evaluate the program and to advocate for progressive housing policies. Written together by members of the Housing First Photovoice group, this collaborative article describes the outcomes from both the Housing First program and the Photovoice project and demonstrates the ways in which participatory program evaluations can interact with client-driven programs like Housing First to produce a cumulative, transformative impact...
March 2018: American Journal of Community Psychology
https://www.readbyqxmd.com/read/29284432/mujeres-fuertes-y-corazones-saludables-adaptation-of-the-strongwomen-healthy-hearts-program-for-rural-latinas-using-an-intervention-mapping-approach
#9
Cynthia K Perry, Jean C McCalmont, Judy P Ward, Hannah-Dulya K Menelas, Christie Jackson, Jazmyne R De Witz, Emma Solanki, Rebecca A Seguin
OBJECTIVE: To describe our use of intervention mapping as a systematic method to adapt an evidence-based physical activity and nutrition program to reflect the needs of rural Latinas. METHODS: An intervention mapping process involving six steps guided the adaptation of an evidence based physical activity and nutrition program, using a community-based participatory research approach. We partnered with a community advisory board of rural Latinas throughout the adaptation process...
December 28, 2017: BMC Public Health
https://www.readbyqxmd.com/read/29207929/a-nationwide-danish-survey-on-the-use-of-green-spaces-by-people-with-mobility-disabilities
#10
Ulrika K Stigsdotter, Sus Sola Corazon, Ola Ekholm
BACKGROUND: There is increasing awareness of the importance and health benefits of living near green spaces. Research usually focuses on the general population's use of green spaces and there has been little focus on the use of green spaces by specific groups, such as people with mobility disabilities. This represents a significant knowledge gap with regard to facilitating access to healthy green environments by all population groups. This study aims to provide knowledge of the use of green spaces by people with mobility disabilities...
December 1, 2017: Scandinavian Journal of Public Health
https://www.readbyqxmd.com/read/29049825/comparison-of-clinical-characteristics-and-outcomes-of-peripartum-cardiomyopathy-between-african-american-and-non-african-american-women
#11
Olga Corazón Irizarry, Lisa D Levine, Jennifer Lewey, Theresa Boyer, Valerie Riis, Michal A Elovitz, Zolt Arany
Importance: Peripartum cardiomyopathy (PPCM) disproportionately affects women of African ancestry, but well-powered studies to explore differences in severity of disease and clinical outcomes are lacking. Objective: To compare the clinical characteristics, presentation, and outcomes of PPCM between African American and non-African American women. Design, Setting, and Participants: This retrospective cohort study using data from January 1, 1986, through December 31, 2016, performed at the University of Pennsylvania Health System, a tertiary referral center serving a population with a high proportion of African American individuals, included 220 women with PPCM...
November 1, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/28918980/outcomes-of-aortic-valve-replacement-according-to-surgical-approach-in-intermediate-and-low-risk-patients-a-propensity-score-analysis
#12
Corazon M Calle-Valda, Rio Aguilar, Amparo Benedicto, Anas Sarraj, Emilio Monguio, Daniel Munoz, Nieves De Antonio, Guillermo Reyes
BACKGROUND: Previous trials have shown that, among high-risk patients with aortic stenosis, survival rates are similar for transcatheter aortic-valve implantation (TAVI) and surgical aortic valve replacement. The study aimed to compare the outcomes of aortic valve replacement according to the adopted surgical approach in intermediate and low risk patients. METHODS: This is a retrospective, observational, cohort study of prospectively collected data from 421 patients undergoing isolated aortic valve replacement between 2011 and 2015...
September 6, 2017: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/28661433/health-promoting-nature-access-for-people-with-mobility-impairments-a-systematic-review
#13
REVIEW
Gaochao Zhang, Dorthe V Poulsen, Victoria L Lygum, Sus S Corazon, Marie C Gramkow, Ulrika K Stigsdotter
This study systematically evaluated the scientific evidence for health benefits of natural environments for people with mobility impairments. Literature searches based on five categories of terms-target group, nature type, health-related impacts, nature-related activities and accessibility issues-were conducted in four databases (Web of Science, Scopus, CAB ABSTRACT and Medline). Twenty-seven articles from 4196 hits were included in the systematic reviews. We concluded that people with mobility disabilities could gain different health benefits, including physical health benefits, mental health benefits and social health benefits from nature in different kinds of nature contacts ranging from passive contact, active involvement to rehabilitative interventions...
June 29, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28528275/it-is-not-all-bad-for-the-grey-city-a-crossover-study-on-physiological-and-psychological-restoration-in-a-forest-and-an-urban-environment
#14
Ulrika K Stigsdotter, Sus Sola Corazon, Ulrik Sidenius, Jesper Kristiansen, Patrik Grahn
Today, urbanization presents a challenge to urban planning with regard to creating healthy living environments. The aim of this research is to gain further knowledge of the restorativeness of a best case urban and natural environment: that is a historic down town urban environment and forest environment located in an arboretum. The study has a cross-over design where 51 (N) female university students are exposed to the two environments through both seated viewing and walking. A mixed method approach is used with both physiological measurements of blood pressure (BP) and heart rate variability (HRV) and psychological measurements of mood change and perceived restorativeness...
May 18, 2017: Health & Place
https://www.readbyqxmd.com/read/28440996/-quality-dimensions-focused-on-the-healthcare-protocol-infarction-code-c%C3%A3-digo-infarto
#15
Jesús Arriaga-Dávila, Gilberto Pérez-Rodríguez, Gabriela Borrayo-Sánchez
The Código Infarto (Infarction Code) strategy is part of the comprehensive care program "A Todo Corazón" (To All Heart), whose aim is to reinforce the prevention and health care of cardiovascular diseases. Mexico faces a big challenge, since it is the country with greater mortality secondary to acute myocardial infarction (AMI) in the first 30 days in patients of 45 years or older (28% compared with 7.9% of the average). In addition, Mexico's population has a high prevalence of risk factors (hypertension, diabetes, tobacco use, dyslipidemias, overweight, and obesity)...
May 2017: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/28359490/how-could-these-mini-saccular-aneurysms-of-ascending-aorta-be-classified
#16
Anas Sarraj, Daniel-Edgardo Muñoz, Corazón-Mabel Calle Valda, Emilio Monguio, Guillermo Reyes
The wall of a true aneurysm is composed of all histologic layers of the aorta. A false aneurysm represents a small, contained rupture of aorta followed by bulging of the corresponding area that is usually sustained by a fibrous peel. Aortic dissection is defined as a separation of the lamellae of the aortic wall. Herein, we describe an unusual clinical presentation of aortic dissection in a 37-year-old male patient that presented severe aortic regurgitation and unusual bulges with linear intimal fissures in ascending aorta underwent mechanical aortic valve replacement and interposition of tubular vascular graft in ascending aorta...
April 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28359487/new-presentation-of-hemolysis-after-papillary-muscles-approximation-for-mitral-valve-repair
#17
Anas Sarraj, Corazón-Mabel Calle Valda, Daniel-Edgardo Muñoz, Guillermo Reyes
Hemolysis is a well-recognized complication after prosthetic valve replacement, especially with perivalvular leaks. Hemolytic anemia associated with mitral valve (MV) repair is less common. We report the case of a young man with severe hemolytic anemia caused by turbulence of blood flow through a very small quadrangle orifice due to early failure of MV repair. The patient underwent redo MV biologic prosthesis replacement and tricuspid valve annuloplasty. The hemolysis completely disappeared few months later...
April 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28341840/comparison-of-two-massively-parallel-sequencing-platforms-using-83-single-nucleotide-polymorphisms-for-human-identification
#18
Dame Loveliness T Apaga, Sheila E Dennis, Jazelyn M Salvador, Gayvelline C Calacal, Maria Corazon A De Ungria
The potential of Massively Parallel Sequencing (MPS) technology to vastly expand the capabilities of human identification led to the emergence of different MPS platforms that use forensically relevant genetic markers. Two of the MPS platforms that are currently available are the MiSeq(®) FGx™ Forensic Genomics System (Illumina) and the HID-Ion Personal Genome Machine (PGM)™ (Thermo Fisher Scientific). These are coupled with the ForenSeq™ DNA Signature Prep kit (Illumina) and the HID-Ion AmpliSeq™ Identity Panel (Thermo Fisher Scientific), respectively...
March 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28333998/calibrating-coseismic-coastal-land-level-changes-during-the-2014-iquique-mw-8-2-earthquake-northern-chile-with-leveling-gps-and-intertidal-biota
#19
Eduardo Jaramillo, Daniel Melnick, Juan Carlos Baez, Henry Montecino, Nelson A Lagos, Emilio Acuña, Mario Manzano, Patricio A Camus
The April 1st 2014 Iquique earthquake (MW 8.1) occurred along the northern Chile margin where the Nazca plate is subducted below the South American continent. The last great megathrust earthquake here, in 1877 of Mw ~8.8 opened a seismic gap, which was only partly closed by the 2014 earthquake. Prior to the earthquake in 2013, and shortly after it we compared data from leveled benchmarks, deployed campaign GPS instruments, continuous GPS stations and estimated sea levels using the upper vertical level of rocky shore benthic organisms including algae, barnacles, and mussels...
2017: PloS One
https://www.readbyqxmd.com/read/28296374/-protocol-for-the-care-of-acute-myocardial-infarction-in-emergency-c%C3%A3-digo-infarto-the-infarction-code
#20
Gabriela Borrayo-Sánchez, Gilberto Pérez-Rodríguez, Olga Georgina Martínez-Montañez, Eduardo Almeida-Gutiérrez, Erick Ramírez-Arias, Joel Estrada-Gallegos, Norma Magdalena Palacios-Jiménez, Martín Rosas-Peralta, Efraín Arizmendi-Uribe, Jesús Arriaga-Dávila
Cardiovascular diseases are a major public health problem because of their they impact on more than 30% of all deaths worldwide. In our country and in the Instituto Mexicano del Seguro Social (IMSS) are also the leading cause of death and the main cause of lost of healthy life years due to disability or premature death. 50% of deaths are premature; most of them are due to acute myocardial infarct. However, the investment for cardiovascular health is poor and there are no comprehensive cares programs focused on the treatment of this diseases or the control of their risk factors...
March 2017: Revista Médica del Instituto Mexicano del Seguro Social
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