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pericyte progenitor cell

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https://www.readbyqxmd.com/read/28196035/perivascular-stem-cells-diminish-muscle-atrophy-following-massive-rotator-cuff-tears-in-a-small-animal-model
#1
Claire D Eliasberg, Ayelet Dar, Andrew R Jensen, Iain R Murray, Winters R Hardy, Tomasz J Kowalski, Cameron A Garagozlo, Kyle M Natsuhara, Adam Z Khan, Owen J McBride, Peter I Cha, Benjamin V Kelley, Denis Evseenko, Brian T Feeley, David R McAllister, Bruno Péault, Frank A Petrigliano
BACKGROUND: Rotator cuff tears are a common cause of shoulder pain and often necessitate operative repair. Muscle atrophy, fibrosis, and fatty infiltration can develop after rotator cuff tears, which may compromise surgical outcomes. This study investigated the regenerative potential of 2 human adipose-derived progenitor cell lineages in a murine model of massive rotator cuff tears. METHODS: Ninety immunodeficient mice were used (15 groups of 6 mice). Mice were assigned to 1 of 3 surgical procedures: sham, supraspinatus and infraspinatus tendon transection (TT), or TT and denervation via suprascapular nerve transection (TT + DN)...
February 15, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28142208/intravenously-transplanted-human-bone-marrow-endothelial-progenitor-cells-engraft-within-brain-capillaries-preserve-mitochondrial-morphology-and-display-pinocytotic-activity-towards-bbb-repair-in-ischemic-stroke-rats
#2
Svitlana Garbuzova-Davis, Edward Haller, Roger Lin, Cesario V Borlongan
Stroke is a life threatening disease with limited therapeutic options. Cell therapy has emerged as an experimental stroke treatment. Blood-brain barrier (BBB) impairment is a key pathological manifestation of ischemic stroke, and barrier repair is an innovative target for neurorestoration in stroke. Here, we evaluated via electron microscopy the ability of transplanted human bone marrow endothelial progenitor cells (hBMEPCs) to repair the BBB in adult Sprague-Dawley rats subjected to transient middle cerebral artery occlusion (tMCAO)...
January 31, 2017: Stem Cells
https://www.readbyqxmd.com/read/28131704/notch3-deficiency-impairs-coronary-microvascular-maturation-and-reduces-cardiac-recovery-after-myocardial-ischemia
#3
Yong-Kang Tao, Heng Zeng, Guo-Qiang Zhang, Sean T Chen, Xue-Jiao Xie, Xiaochen He, Shuo Wang, Hongyan Wen, Jian-Xiong Chen
RATIONALE: Vascular maturation plays an important role in wound repair post-myocardial infarction (MI). The Notch3 is critical for pericyte recruitment and vascular maturation during embryonic development. OBJECTIVE: This study is to test whether Notch3 deficiency impairs vascular maturation and blunts cardiac functional recovery post-MI. APPROACH AND RESULTS: Wild type (WT) and Notch3 knockout (Notch3KO) mice were subjected to MI by the ligation of left anterior descending coronary artery (LAD)...
January 24, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28111199/pericytes-of-multiple-organs-do-not-behave-as-mesenchymal-stem-cells-in%C3%A2-vivo
#4
Nuno Guimarães-Camboa, Paola Cattaneo, Yunfu Sun, Thomas Moore-Morris, Yusu Gu, Nancy D Dalton, Edward Rockenstein, Eliezer Masliah, Kirk L Peterson, William B Stallcup, Ju Chen, Sylvia M Evans
Pericytes are widely believed to function as mesenchymal stem cells (MSCs), multipotent tissue-resident progenitors with great potential for regenerative medicine. Cultured pericytes isolated from distinct tissues can differentiate into multiple cell types in vitro or following transplantation in vivo. However, the cell fate plasticity of endogenous pericytes in vivo remains unclear. Here, we show that the transcription factor Tbx18 selectively marks pericytes and vascular smooth muscle cells in multiple organs of adult mouse...
January 9, 2017: Cell Stem Cell
https://www.readbyqxmd.com/read/28074532/pathogenesis-of-developmental-anomalies-of-the-central-nervous-system-induced-by-congenital-cytomegalovirus-infection
#5
REVIEW
Hideya Kawasaki, Isao Kosugi, Shiori Meguro, Toshihide Iwashita
In humans, the herpes virus family member cytomegalovirus (CMV) is the most prevalent mediator of intrauterine infection-induced congenital defect. Central nervous system (CNS) dysfunction is a distinguishing symptom of CMV infection, and characterized by ventriculoencephalitis and microglial nodular encephalitis. Reports on the initial distribution of CMV particles and its receptors on the blood brain barrier (BBB) are rare. Nevertheless, several factors are suggested to affect CMV etiology. Viral particle size is the primary factor in determining the pattern of CNS infections, followed by the expression of integrin β1 in endothelial cells, pericytes, meninges, choroid plexus, and neural stem progenitor cells (NSPCs), which are the primary targets of CMV infection...
February 2017: Pathology International
https://www.readbyqxmd.com/read/28035017/muscle-damage-and-inflammation-during-recovery-from-exercise
#6
Jonathan M Peake, Oliver Neubauer, Paul A Della Gatta, Kazunori Nosaka
Unaccustomed exercise consisting of eccentric (i.e., lengthening) muscle contractions often results in muscle damage characterized by ultrastructural alterations in muscle tissue, clinical signs and symptoms (e.g., reduced muscle strength and range of motion, increased muscle soreness and swelling, efflux of myocellular proteins). The time course of recovery following exercise-induced muscle damage depends on the extent of initial muscle damage, which in turn is influenced by the intensity and duration of exercise, joint angle/muscle length and muscle groups used during exercise...
December 29, 2016: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28026856/gene-tracing-analysis-reveals-the-contribution-of-neural-crest-derived-cells-in-pituitary-development
#7
Hiroki Ueharu, Saishu Yoshida, Takako Kikkawa, Naoko Kanno, Masashi Higuchi, Takako Kato, Noriko Osumi, Yukio Kato
The anterior pituitary originates from the adenohypophyseal placode. Both the preplacode region and neural crest (NC) derive from subdivision of the neural border region, and further individualization of the placode domain is established by a reciprocal interaction between placodal precursors and NC cells (NCCs). It has long been known that NCCs are present in the adenohypophysis as interstitial cells. A recent report demonstrated that NCCs also contribute to the formation of pericytes in the developing pituitary...
December 27, 2016: Journal of Anatomy
https://www.readbyqxmd.com/read/28004288/in-vivo-quantification-of-the-revascularization-of-a-human-acellular-dermis-seeded-with-epcs-and-mscs-in-co-culture-with-fibroblasts-and-pericytes-in-the-dorsal-chamber-model-in-pre-irradiated-tissue
#8
M Vitacolonna, D Belharazem, P Hohenberger, E D Roessner
INTRODUCTION: Transplantation of a cell-seeded graft may improve wound healing after radiotherapy. However, the survival of the seeded cells depends on a rapid vascularization of the graft. Co-culturing of adult stem cells may be a promising strategy to accelerate the vessel formation inside the graft. Thus, we compared the in vivo angiogenic potency of mesenchymal stem cells (MSC) and endothelial progenitor cells (EPC) using dorsal skinfold chambers and intravital microscopy. MATERIALS AND METHODS: Cells were isolated from rat bone marrow and adipose tissue and characterized by immunostaining and flow cytometry...
December 21, 2016: Cell and Tissue Banking
https://www.readbyqxmd.com/read/27990124/endothelial-progenitor-cells-physiology-and-metabolic-plasticity-in-brain-angiogenesis-and-blood-brain-barrier-modeling
#9
REVIEW
Natalia A Malinovskaya, Yulia K Komleva, Vladimir V Salmin, Andrey V Morgun, Anton N Shuvaev, Yulia A Panina, Elizaveta B Boitsova, Alla B Salmina
Currently, there is a considerable interest to the assessment of blood-brain barrier (BBB) development as a part of cerebral angiogenesis developmental program. Embryonic and adult angiogenesis in the brain is governed by the coordinated activity of endothelial progenitor cells, brain microvascular endothelial cells, and non-endothelial cells contributing to the establishment of the BBB (pericytes, astrocytes, neurons). Metabolic and functional plasticity of endothelial progenitor cells controls their timely recruitment, precise homing to the brain microvessels, and efficient support of brain angiogenesis...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27935037/an-isogenic-blood-brain-barrier-model-comprising-brain-endothelial-cells-astrocytes-and-neurons-derived-from-human-induced-pluripotent-stem-cells
#10
Scott G Canfield, Matthew J Stebbins, Bethsymarie Soto Morales, Shusaku W Asai, Gad D Vatine, Clive N Svendsen, Sean P Palecek, Eric V Shusta
The blood-brain barrier (BBB) is critical in maintaining a physical and metabolic barrier between the blood and the brain. The BBB consists of brain microvascular endothelial cells (BMECs) that line the brain vasculature and combine with astrocytes, neurons and pericytes to form the neurovascular unit (NVU). We hypothesized that astrocytes and neurons generated from human induced pluripotent stem cells (iPSCs) could induce BBB phenotypes in iPSC-derived BMECs, creating a robust multicellular human BBB model...
December 9, 2016: Journal of Neurochemistry
https://www.readbyqxmd.com/read/27866791/mesenchymal-stem-cells-the-roles-and-functions-in-cutaneous-wound-healing-and-tumor-growth
#11
REVIEW
Sei-Ichiro Motegi, Osamu Ishikawa
Mesenchymal stem cells (MSCs) are bone marrow-derived non-hematopoietic progenitor cells. MSCs are able to differentiate into various types of cells, including chondrocytes, adipocytes, osteocytes, myocytes, endothelial cells, and keratinocytes. There is increasing evidence that MSCs might be located external to the vasculature, and that perivascular cells in the skin, generally called as "pericytes", might include MSCs. It has been suggested that MSCs localized around blood vessels might migrate into wounds and contribute to the restoration of injured tissues...
November 11, 2016: Journal of Dermatological Science
https://www.readbyqxmd.com/read/27833970/subsets-of-telocytes-the-progenitor-cells-in-the-human-endocardial-niche
#12
Florentina Grigoriu, Sorin Hostiuc, Alexandra Diana Vrapciu, Mugurel Constantin Rusu
: Telocytes (TCs) are cells defined by their long and moniliform processes termed telopodes. They were previously identified in the endocardium and express neural markers, such as nestin and neuron-specific enolase (NSE). Previous studies found a positive expression of neuro-filaments in endocardial endothelial cells, and a positive expression of nestin in cardiac side population (CSP) progenitor cells, which allowed us to hypothesize that TCs in the endocardial stem niche could be in fact progenitors that express nestin...
2016: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/27789253/the-gene-expression-profile-of-non-cultured-highly-purified-human-adipose-tissue-pericytes-transcriptomic-evidence-that-pericytes-are-stem-cells-in-human-adipose-tissue
#13
Lindolfo da Silva Meirelles, Virgínia Mara de Deus Wagatsuma, Tathiane Maistro Malta, Patrícia Viana Bonini Palma, Amélia Goes Araújo, Rodrigo Alexandre Panepucci, Wilson Araújo Silva, Simone Kashima, Dimas Tadeu Covas
Pericytes (PCs) are a subset of perivascular cells that can give rise to mesenchymal stromal cells (MSCs) when culture-expanded, and are postulated to give rise to MSC-like cells during tissue repair in vivo. PCs have been suggested to behave as stem cells (SCs) in situ in animal models, although evidence for this role in humans is lacking. Here, we analyzed the transcriptomes of highly purified, non-cultured adipose tissue (AT)-derived PCs (ATPCs) to detect gene expression changes that occur as they acquire MSC characteristics in vitro, and evaluated the hypothesis that human ATPCs exhibit a gene expression profile compatible with an AT SC phenotype...
October 24, 2016: Experimental Cell Research
https://www.readbyqxmd.com/read/27777113/subsets-of-telocytes-myocardial-telocytes
#14
M C Rusu, S Hostiuc, A D Vrapciu, L Mogoantă, V S Mănoiu, F Grigoriu
Telocytes (TCs) are morphologically defined as small-sized cells with long, thin, moniliform processes called telopodes (Tps). Numerous papers imply that TCs are a distinctive cell type, and that transmission electron microscopy (TEM) is the gold standard tool for their identification. We aimed to reproduce previous studies on myocardial TCs to check their validity. For this purpose we performed an immunohistochemical study on human cardiac samples from six autopsied donor cadavers, using antibodies against CD10, CD31, CD34, CD146, Ki67, alpha-smooth muscle actin (α-SMA), Platelet-Derived Growth Factor Receptor-alpha (PDGFRα) and laminin...
January 2017: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/27742569/the-double-life-of-cardiac-mesenchymal-cells-epimetabolic-sensors-and-therapeutic-assets-for-heart-regeneration
#15
Chiara Cencioni, Sandra Atlante, Matteo Savoia, Fabio Martelli, Antonella Farsetti, Maurizio C Capogrossi, Andreas M Zeiher, Carlo Gaetano, Francesco Spallotta
Organ-specific mesenchymal cells naturally reside in the stroma, where they are exposed to some environmental variables affecting their biology and functions. Risk factors such as diabetes or aging influence their adaptive response. In these cases, permanent epigenetic modifications may be introduced in the cells with important consequences on their local homeostatic activity and therapeutic potential. Numerous results suggest that mesenchymal cells, virtually present in every organ, may contribute to tissue regeneration mostly by paracrine mechanisms...
October 11, 2016: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/27738435/vascular-transdifferentiation-in-the-cns-a-focus-on-neural-and-glioblastoma-stem-like-cells
#16
Sophie Guelfi, Hugues Duffau, Luc Bauchet, Bernard Rothhut, Jean-Philippe Hugnot
Glioblastomas are devastating and extensively vascularized brain tumors from which glioblastoma stem-like cells (GSCs) have been isolated by many groups. These cells have a high tumorigenic potential and the capacity to generate heterogeneous phenotypes. There is growing evidence to support the possibility that these cells are derived from the accumulation of mutations in adult neural stem cells (NSCs) as well as in oligodendrocyte progenitors. It was recently reported that GSCs could transdifferentiate into endothelial-like and pericyte-like cells both in vitro and in vivo, notably under the influence of Notch and TGFβ signaling pathways...
2016: Stem Cells International
https://www.readbyqxmd.com/read/27702398/mesenchymal-stem-cells-and-pericytes-to-what-extent-are-they-related
#17
Lucas Eduardo Botelho de Souza, Tathiane Maistro Malta, Simone Kashima Haddad, Dimas Tadeu Covas
Mesenchymal stem cells (MSCs) were initially identified as progenitors of skeletal tissues within mammalian bone marrow and cells with similar properties were also obtained from other tissues such as adipose and dental pulp. Although MSCs have been extensively investigated, their native behavior and in vivo identity remain poorly defined. Uncovering the in vivo identity of MSCs has been challenging due to the lack of exclusive cell markers, cellular alterations caused by culture methods, and extensive focus on in vitro properties for characterization...
December 15, 2016: Stem Cells and Development
https://www.readbyqxmd.com/read/27678158/human-kidney-pericytes-produce-renin
#18
Ania Stefanska, Christopher Kenyon, Helen C Christian, Charlotte Buckley, Isaac Shaw, John J Mullins, Bruno Péault
Pericytes, perivascular cells embedded in the microvascular wall, are crucial for vascular homeostasis. These cells also play diverse roles in tissue development and regeneration as multi-lineage progenitors, immunomodulatory cells and as sources of trophic factors. Here, we establish that pericytes are renin producing cells in the human kidney. Renin was localized by immunohistochemistry in CD146 and NG2 expressing pericytes, surrounding juxtaglomerular and afferent arterioles. Similar to pericytes from other organs, CD146(+)CD34(-)CD45(-)CD56(-) renal fetal pericytes, sorted by flow cytometry, exhibited tri-lineage mesodermal differentiation potential in vitro...
December 2016: Kidney International
https://www.readbyqxmd.com/read/27671872/cerebrovascular-defects-in-foxc1-mutants-correlate-with-aberrant-wnt-and-vegf-a-pathways-downstream-of-retinoic-acid-from-the-meninges
#19
Swati Mishra, Youngshik Choe, Samuel J Pleasure, Julie A Siegenthaler
Growth and maturation of the cerebrovasculature is a vital event in neocortical development however mechanisms that control cerebrovascular development remain poorly understood. Mutations in or deletions that include the FOXC1 gene are associated with congenital cerebrovascular anomalies and increased stroke risk in patients. Foxc1 mutant mice display severe cerebrovascular hemorrhage at late gestational ages. While these data demonstrate Foxc1 is required for cerebrovascular development, its broad expression in the brain vasculature combined with Foxc1 mutant's complex developmental defects have made it difficult to pinpoint its function(s)...
December 1, 2016: Developmental Biology
https://www.readbyqxmd.com/read/27608497/pericyte-fibroblast-transition-promotes-tumor-growth-and-metastasis
#20
Kayoko Hosaka, Yunlong Yang, Takahiro Seki, Carina Fischer, Olivier Dubey, Erik Fredlund, Johan Hartman, Piotr Religa, Hiromasa Morikawa, Yoko Ishii, Masakiyo Sasahara, Ola Larsson, Giulio Cossu, Renhai Cao, Sharon Lim, Yihai Cao
Vascular pericytes, an important cellular component in the tumor microenvironment, are often associated with tumor vasculatures, and their functions in cancer invasion and metastasis are poorly understood. Here we show that PDGF-BB induces pericyte-fibroblast transition (PFT), which significantly contributes to tumor invasion and metastasis. Gain- and loss-of-function experiments demonstrate that PDGF-BB-PDGFRβ signaling promotes PFT both in vitro and in in vivo tumors. Genome-wide expression analysis indicates that PDGF-BB-activated pericytes acquire mesenchymal progenitor features...
September 20, 2016: Proceedings of the National Academy of Sciences of the United States of America
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