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https://www.readbyqxmd.com/read/28088233/successful-recovery-from-a-subclavicular-ulcer-caused-by-lenvatinib-for-thyroid-cancer-a-case-report
#1
Morimasa Kitamura, Tomomasa Hayashi, Chiaki Suzuki, Shigeru Hirano, Ichiro Tateya, Yo Kishimoto, Koichi Omori
BACKGROUND: There are currently no effective therapeutic methods for locally recurrent, metastatic, or progressive radioactive iodine (RAI)-refractory differentiated thyroid cancer. However, multitargeted tyrosine kinase inhibitors (TKIs) such as lenvatinib or sorafenib have been approved for patients with RAI-refractory differentiated thyroid cancer as a second targeted therapy, and these agents can prolong patient survival. However, several cases have been reported that TKIs have caused fatal complications such as fistula formation or bleeding...
January 14, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28087527/floc-formation-reduces-the-ph-stress-experienced-by-microorganisms-living-in-alkaline-environments
#2
C J Charles, S P Rout, K A Patel, S Akbar, A P Laws, B R Jackson, S A Boxall, P N Humphreys
: The survival of microorganisms within a cementitious geological disposal facility for radioactive wastes is heavily dependent on their ability to survive the calcium dominated, hyper-alkaline conditions resulting from the dissolution of the cementitious materials. The present study shows that the formation of flocs, composed of a complex mixture of extracellular polymeric substances (EPS), provides protection against alkaline pH values up to pH 13.0. The flocs were dominated by Alishewanella and Dietzia sp, producing a mannose rich carbohydrate fraction incorporating extracellular DNA, resulting in Ca(2+) sequestration...
January 13, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28087377/in-vivo-biodistribution-and-imaging-studies-with-a-99m-tc-radiolabeled-derivative-of-the-c-terminus-of-prothymosin-alpha-in-mice-bearing-experimentally-induced-inflammation
#3
Chrysoula-Evangelia Karachaliou, Charalampos Triantis, Christos Liolios, Lazaros Palamaris, Christos Zikos, Ourania E Tsitsilonis, Hubert Kalbacher, Wolfgang Voelter, George Loudos, Minas Papadopoulos, Ioannis Pirmettis, Evangelia Livaniou
Prothymosin alpha (ProTα) is a highly conserved mammalian polypeptide (109 amino acids in man) exerting in vitro and in vivo immunoenhancing activities. Recently, our team has developed a (99m)Tc-radiolabeled derivative of the C-terminal bioactive decapeptide of ProTα ([(99m)Tc]C1) and employed it in in vitro studies, the results of which support the existence of binding sites on human neutrophils that recognize [(99m)Tc]C1, intact ProTα as well as the C-terminal decapeptide of ProTα and presumably involve Toll-like receptor 4...
January 11, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28086912/wwl70-attenuates-pge2-production-derived-from-2-arachidonoylglycerol-in-microglia-by-abhd6-independent-mechanism
#4
Mikiei Tanaka, Sean Moran, Jie Wen, Kwame Affram, Tinghua Chen, Aviva J Symes, Yumin Zhang
BACKGROUND: α/β-Hydrolase domain 6 (ABHD6) is one of the major enzymes for endocannabinoid 2-arachidonoylglycerol (2-AG) hydrolysis in microglia cells. Our recent studies have shown that a selective ABHD6 inhibitor WWL70 has anti-inflammatory and neuroprotective effects in animal models of traumatic brain injury and multiple sclerosis. However, the role of ABHD6 in the neuroinflammatory response and the mechanisms by which WWL70 suppresses inflammation has not yet been elucidated in reactive microglia...
January 10, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/28081335/comparison-of-wire-guided-localization-and-radio-guided-occult-lesionlocalization-in-preoperative-localization-of-nonpalpable-breast-lesions
#5
Nazım Barış Kanat, Murat Tuncel, Tamer Aksoy, Ayşegül Fırat, Figen Demirkazık, Demirali Onat, Meltem Çağlar Tuncalı, Biray Emine Caner
BACKGROUND/AIM: Breast lesions that are not palpable on physical examination but considered suspicious for malignancy on mammography or ultrasonography should be marked before surgery. Wire-guided localization (WGL) is the most frequently used method for preoperative marking of nonpalpable breast lesions (NPBLs). An alternative is marking by a radioactive agent (radio-guided occult lesion localization; ROLL). The present study aimed to compare WGL and ROLL for preoperative marking. MATERIALS AND METHODS: The study included 25 patients marked by ROLL and 11 patients marked by WGL...
December 20, 2016: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28081011/spectrum-reconstruction-method-based-on-the-detector-response-model-calibrated-by-x-ray-fluorescence
#6
Ruizhe Li, Liang Li, Zhiqiang Chen
Accurate estimation of distortion-free spectra is important but difficult in various applications, especially for spectral computed tomography. Two key problems must be solved to reconstruct the incident spectrum. One is the acquisition of the detector energy response. It can be calculated by Monte Carlo simulation, which requires detailed modeling of the detector system and a high computational power. It can also be acquired by establishing a parametric response model and be calibrated using monochromatic x-ray sources, such as synchrotron sources or radioactive isotopes...
January 12, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28077340/clinicopathological-characteristics-of-papillary-thyroid-cancer-in-children-with-emphasis-on-the-pubertal-status-and-association-with-brafv600e-mutation
#7
Şükran Poyrazoğlu, Rüveyde Bundak, Firdevs Baş, Gülçin Yeğen, Yasemin Şanlı, Feyza Darendeliler
OBJECTIVE: Papillary thyroid cancer (PTC) could behave differently in prepubertal than in pubertal children and between children and adults. BRAF gene activating mutations may associate with PTC by creating aberrant activation. We aimed to evaluate clinicopathological characteristics of PTC patients with emphasis on the pubertal status and investigate the association of BRAFV600E mutation with disease characteristics. METHODS: Medical records of 75 patients with PTC were reviewed retrospectively...
January 12, 2017: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/28069541/a-bispecific-tribody-pet-radioligand-for-visualization-of-amyloid-beta-protofibrils-a-new-concept-for-neuroimaging
#8
Stina Syvänen, Xiaotian T Fang, Greta Hultqvist, Silvio R Meier, Lars Lannfelt, Dag Sehlin
Antibodies are highly specific for their target molecules, but their poor brain penetrance has restricted their use as PET ligands for imaging of targets within the CNS. The aim of this study was to develop an antibody-based radioligand, using the Tribody(TM) format, for PET imaging of soluble amyloid-beta (Aβ) protofibrils, which are suggested to cause neurodegeneration in Alzheimer's disease. Antibodies, even when expressed in smaller engineered formats, are large molecules that do not enter the brain in sufficient amounts for imaging purposes...
January 6, 2017: NeuroImage
https://www.readbyqxmd.com/read/28069315/long-term-non-isothermal-reactive-transport-model-of-compacted-bentonite-concrete-and-corrosion-products-in-a-hlw-repository-in-clay
#9
Alba Mon, Javier Samper, Luis Montenegro, Acacia Naves, Jesús Fernández
Radioactive waste disposal in deep geological repositories envisages engineered barriers such as carbon-steel canisters, compacted bentonite and concrete liners. The stability and performance of the bentonite barrier could be affected by the corrosion products at the canister-bentonite interface and the hyper-alkaline conditions caused by the degradation of concrete at the bentonite-concrete interface. Additionally, the host clay formation could also be affected by the hyper-alkaline plume at the concrete-clay interface...
December 24, 2016: Journal of Contaminant Hydrology
https://www.readbyqxmd.com/read/28068555/activity-concentration-measurements-of-selected-radionuclides-in-seals-from-canadian-arctic
#10
Jing Chen, Weihua Zhang, Baki Sadi, Xiaowa Wang, Derek C G Muir
The activity concentrations of naturally occurring radionuclides (such as (226)Ra, (210)Pb and (210)Po) and long lived (137)Cs were measured in a total of 119 tissue samples (43 blubber, 43 liver, and 33 muscle samples) from 40 ringed seals and 4 bearded seals collected in the Arviat area of Canada during the fall of 2014. Activity concentration of (210)Po was measured in all seal liver and muscle samples individually. The average (210)Po activity concentrations were 25 ± 7.6 Bq/kg fresh weight (fw) in muscle and 211 ± 58 Bq/kg fw in liver for ringed seals, and 20 ± 6...
January 6, 2017: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/28068401/advantages-of-synthetic-noise-and-machine-learning-for-analyzing-radioecological-data-sets
#11
Igor Shuryak
The ecological effects of accidental or malicious radioactive contamination are insufficiently understood because of the hazards and difficulties associated with conducting studies in radioactively-polluted areas. Data sets from severely contaminated locations can therefore be small. Moreover, many potentially important factors, such as soil concentrations of toxic chemicals, pH, and temperature, can be correlated with radiation levels and with each other. In such situations, commonly-used statistical techniques like generalized linear models (GLMs) may not be able to provide useful information about how radiation and/or these other variables affect the outcome (e...
2017: PloS One
https://www.readbyqxmd.com/read/28067537/a-farmhouse-son-in-law-and-radiation
#12
S Endo
The residents of Suetsugi in Fukushima Prefecture measured ambient dose rates and radiocaesium concentrations in the soil after the accident at Fukushima Daiichi nuclear power plant in an attempt to maintain living conditions in the region. The measurements were colour plotted into maps to visualise the contamination. Through the receipt of external support, a number of radioactivity-related initiatives were implemented for the residents. Studies were also undertaken regarding the impact of radiocaesium contamination on rice farming in Suetsugi following the Great East Japan Earthquake and the accident at Fukushima Daiichi nuclear power plant...
January 1, 2017: Annals of the ICRP
https://www.readbyqxmd.com/read/28066888/technical-note-a-new-zeolite-pet-phantom-to-test-segmentation-algorithms-on-heterogeneous-activity-distributions-featured-with-ground-truth-contours
#13
Chiara D Soffientini, Elisabetta De Bernardi, Rosangela Casati, Giuseppe Baselli, Felicia Zito
PURPOSE: Design, realization, scan, and characterization of a phantom for PET Automatic Segmentation (PET-AS) assessment are presented. Radioactive zeolites immersed in a radioactive heterogeneous background simulate realistic wall-less lesions with known irregular shape and known homogeneous or heterogeneous internal activity. METHOD: Three different zeolite families were evaluated in terms of radioactive uptake homogeneity, necessary to define activity and contour ground truth...
November 22, 2016: Medical Physics
https://www.readbyqxmd.com/read/28066807/evaluation-of-cross-calibrated-68-ge-68-ga-phantoms-for-assessing-pet-ct-measurement-bias-in-oncology-imaging-for-single-and-multicenter-trials
#14
Darrin W Byrd, Robert K Doot, Keith C Allberg, Lawrence R MacDonald, Wendy A McDougald, Brian F Elston, Hannah M Linden, Paul E Kinahan
Quantitative PET imaging is an important tool for clinical trials evaluating the response of cancers to investigational therapies. The standardized uptake value, used as a quantitative imaging biomarker, is dependent on multiple parameters that may contribute bias and variability. The use of long-lived, sealed PET calibration phantoms offers the advantages of known radioactivity activity concentration and simpler use than aqueous phantoms. We evaluated scanner and dose calibrator sources from two batches of commercially available kits, together at a single site and distributed across a local multicenter PET imaging network...
December 2016: Tomography: a Journal for Imaging Research
https://www.readbyqxmd.com/read/28064175/neuroimaging-of-inflammation-in-memory-and-related-other-disorders-nimrod-study-protocol-a-deep-phenotyping-cohort-study-of-the-role-of-brain-inflammation-in-dementia-depression-and-other-neurological-illnesses
#15
W Richard Bevan-Jones, Ajenthan Surendranathan, Luca Passamonti, Patricia Vázquez Rodríguez, Robert Arnold, Elijah Mak, Li Su, Jonathan P Coles, Tim D Fryer, Young T Hong, Guy Williams, Franklin Aigbirhio, James B Rowe, John T O'Brien
INTRODUCTION: Inflammation of the central nervous system is increasingly regarded as having a role in cognitive disorders such as dementia and depression, but it is not clear how such inflammation relates to other aspects of neuropathology, structural and functional changes in the brain and symptoms (as assessed via clinical and neuropsychological assessment and MRI). This study will explore these pathophysiological mechanisms using positron emission tomography (PET) which allows in vivo imaging of inflammation, amyloid and τ deposition, together with neuropsychological profiling, MRI and peripheral biomarker analysis...
January 7, 2017: BMJ Open
https://www.readbyqxmd.com/read/28063817/pulse-sequence-considerations-for-simulation-and-postimplant-dosimetry-of-prostate-brachytherapy
#16
Jingfei Ma, Marinus A Moerland, Aradhana M Venkatesan, Tharakeswara K Bathala, Rajat J Kudchadker, Kristy K Brock, Steven J Frank
PURPOSE: The purpose of this work is to present a brief review of MRI physics principles pertinent to prostate brachytherapy, and a summary of our experience in optimizing protocols for prostate brachytherapy applications. METHODS AND MATERIALS: We summarized essential MR imaging characteristics and their interplays that need to be considered for prostate brachytherapy applications. These include spatial resolution, signal-to-noise ratio, image contrast, artifacts, geometric distortion, specific absorption rate, and total scan time...
January 4, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28063371/individual-dose-due-to-radioactivity-accidental-release-from-fusion-reactor
#17
Baojie Nie, Muyi Ni, Shiping Wei
As an important index shaping the design of fusion safety system, evaluation of public radiation consequences have risen as a hot topic on the way to develop fusion energy. In this work, the comprehensive public early dose was evaluated due to unit gram tritium (HT/HTO), activated dust, activated corrosion products (ACPs) and activated gases accidental release from ITER like fusion reactor. Meanwhile, considering that we cannot completely eliminate the occurrence likelihood of multi-failure of vacuum vessel and tokamak building, we conservatively evaluated the public radiation consequences and environment restoration after the worst hypothetical accident preliminarily...
December 11, 2016: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28063370/enhanced-desorption-of-cs-from-clays-by-a-polymeric-cation-exchange-agent
#18
Chan Woo Park, Bo Hyun Kim, Hee-Man Yang, Bum-Kyoung Seo, Kune-Woo Lee
We report on a new approach to increase the removal of cesium from contaminated clays based on the intercalation of a cationic polyelectrolyte into the clay interlayers. A highly charged cationic polyelectrolyte, polyethyleneimine (PEI), was shown to intercalate into the negatively charged interlayers and readily replaced Cs ions adsorbed on the interlayers of montmorillonite. The polycation desorbed significantly more Cs strongly bound to the clay than did single cations. Moreover, additional NH4(+) treatment following the PEI treatment enhanced desorption of Cs ions that were less accessible by the bulky polyelectrolyte...
December 21, 2016: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28063322/quantitation-of-rat-cerebral-blood-flow-using-99m-tc-hmpao
#19
Chie Suzuki, Shintaro Kimura, Mutsumi Kosugi, Yasuhiro Magata
INTRODUCTION: Technetium-99m-hexamethylpropyleneamine oxime ((99m)Tc-HMPAO) is potentially useful for the assessment of cerebral blood flow (CBF) in small animals. In this paper, a procedure for quantitation of rat CBF using (99m)Tc-HMPAO was determined. METHODS: Biodistribution of (99m)Tc-radioactivity in normal rats was determined after intravenous administration of (99m)Tc-HMPAO. Acetazolamide treated rats were intravenously administered with the mixture of (99m)Tc-HMPAO and N-isopropyl-[(125)I]iodoamphetamine ([(125)I]IMP), and arterial blood was then collected for 5min...
December 22, 2016: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/28063068/accuracy-of-177-lu-activity-quantification-in-spect-imaging-a-phantom-study
#20
Carlos F Uribe, Pedro L Esquinas, Jesse Tanguay, Marjorie Gonzalez, Emilie Gaudin, Jean-Mathieu Beauregard, Anna Celler
BACKGROUND: The aim of the study is to assess accuracy of activity quantification of (177)Lu studies performed according to recommendations provided by the committee on Medical Internal Radiation Dose (MIRD) pamphlets 23 and 26. The performances of two scatter correction and three segmentation methods were compared. Additionally, the accuracy of tomographic and planar methods for determination of the camera normalization factor (CNF) was evaluated. Eight phantoms containing inserts of different sizes and shapes placed in air, water, and radioactive background were scanned using a Siemens SymbiaT SPECT/CT camera...
December 2017: EJNMMI Physics
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