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https://www.readbyqxmd.com/read/28550398/association-of-tumor-size-and-focality-with-recurrence-persistence-in-papillary-thyroid-cancer-patients-treated-with-total-thyroidectomy-along-with-radioactive-iodine-ablation-and-tsh-suppression
#1
Misbah Khan, Aamir Ali Syed, Amina Iqbal Khan, Syed Raza Hussain, Namra Urooj
Locoregional recurrence is common in papillary thyroid cancer PTC and an optimal surgical treatment with respect to the multifocal nature of the disease stays controversial. It is a retrospective analytical study design. 209 diagnosed PTCs managed at our institute were grouped into macro-PTC with a size of dominant focus >1 cm (unifocal n = 106 and multifocal n = 64) and micro-PTMC if size of all foci was <1 cm; (unifocal n = 16 and multifocal PTMC n = 23). The primary endpoint is recurrence and tumor free survival in each of the four groups...
May 26, 2017: Updates in Surgery
https://www.readbyqxmd.com/read/28548175/the-water-based-synthesis-of-chemically-stable-zr-based-mofs-using-pyridine-containing-ligands-and-their-exceptionally-high-adsorption-capacity-for-iodine
#2
Zhe Wang, Ying Huang, Jian Yang, Yongsheng Li, Qixin Zhuang, Jinlou Gu
The primary pollutant, radioactive iodine (I2), has become a worldwide concern due to its serious ill effects of radiotoxicity on human health. Therefore, it is of great significance to develop novel adsorbents for effectively eliminating I2 from nuclear waste. Herein, we reported a Zr-based MOF adsorbent constructed by utilizing pyridine-containing pyridine-dicarboxylic acid (PYDC) as organic ligands (UiO-66-PYDC) as well as active sites for the efficient removal of I2. UiO-66-PYDC MOFs were synthesized by a hydrothermal strategy and featured good chemical and thermal stabilities, endowing them with the ability to work in harsh environments...
May 26, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28545679/selective-use-of-radioactive-iodine-rai-in-thyroid-cancer-no-longer-one-size-fits-all
#3
REVIEW
J L Marti, L G T Morris, A S Ho
A remarkable, evidence-based trend toward de-escalation has reformed the practice of radioactive iodine (RAI) administration for thyroid cancer patients. Updated guidelines have supported both decreased RAI doses for select populations, as well as expanded definitions of low-risk and intermediate-risk patients that may not require RAI. Correspondingly, there is now increased flexibility for hemithyroidectomy without need for RAI, and relaxed TSH suppression targets for low-risk thyroidectomy patients. Clinical judgment remains indispensable where multiple risk factors co-exist that individually are not indications for RAI...
May 3, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28545122/spot-a-novel-and-streamlined-microarray-platform-for-observing-cellular-trna-levels
#4
Simon Grelet, Ariel McShane, Eveline Hok, Jensen Tomberlin, Philip H Howe, Renaud Geslain
Recent studies have placed transfer RNA (tRNA), a housekeeping molecule, in the heart of fundamental cellular processes such as embryonic development and tumor progression. Such discoveries were contingent on the concomitant development of methods able to deliver high-quality tRNA profiles. The present study describes the proof of concept obtained in Escherichia coli (E. coli) for an original tRNA analysis platform named SPOt (Streamlined Platform for Observing tRNA). This approach comprises three steps. First, E...
2017: PloS One
https://www.readbyqxmd.com/read/28544900/kinetics-of-glucocorticoid-exposure-in-developing-zebrafish-a-tracer-study
#5
Peter Johannes Steenbergen, Nabila Bardine, Faiza Sharif
In the current study the dynamics of glucocorticoid uptake by zebrafish chorionated embryos from the surrounding medium were studied, using 2.5 μM cortisol or dexamethasone solutions complemented with their tritiated variant. We measured the uptake of radioactive cortisol by embryos during a 1 h submersion. Interestingly, the signal in chorionated embryos was 85% (exposure: 1-2 hpf) or 78% (exposure: 48-49 hpf) of the signal present in an equal volume medium. By comparing embryos measured without chorion, we found that 18-20% of the radioactivity present in chorionated embryos is actually bound to the chorion or located in the perivitelline space...
May 12, 2017: Chemosphere
https://www.readbyqxmd.com/read/28543974/neck-sonography-and-suppressed-thyroglobulin-have-high-sensitivity-for-identifying-recurrent-persistent-disease-in-patients-with-low-risk-thyroid-cancer-treated-with-total-thyroidectomy-and-radioactive-iodine-ablation-making-stimulated-thyroglobulin-unnecessary
#6
José M Domínguez, Flavia Nilo, Tania Contreras, Rocío Carmona, Nicolás Droppelmann, Hernán González, Virginia Iturrieta, R Michael Tuttle
OBJECTIVES: Follow-up of patients with low-risk differentiated thyroid cancer treated with total thyroidectomy and radioiodine requires neck sonography and thyroglobulin (Tg). The need to stimulate Tg is controversial. The goal of this study was to compare the diagnostic performances of sonography plus suppressed or stimulated Tg in low-risk thyroid cancer. METHODS: After total thyroidectomy and radioiodine, patients with low-risk thyroid cancer were retrospectively identified as having structural or biochemical persistence/recurrence...
May 24, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28542013/location-modification-factors-for-potential-dose-estimation
#7
Sandra F Snyder, J Matthew Barnett
A U.S. Department of Energy facility must comply with the National Emission Standard for Hazardous Air Pollutants for radioactive air emissions. The standard is an effective dose of less than 0.1 mSv y to the maximum public receptor. Additionally, a lower dose level may be assigned to a specific emission point in a State issued permit. A method to efficiently estimate the expected dose for future emissions is described. This method is most appropriately applied to a research facility with several emission points with generally low emission levels of numerous isotopes...
July 2017: Health Physics
https://www.readbyqxmd.com/read/28542012/trends-of-training-courses-conducted-in-the-human-resources-development-center-of-the-national-institute-for-quantum-and-radiological-science-and-technology-after-the-fukushima-dai-ichi-nuclear-power-plant-accident
#8
Yuko Shimizu, Haruzo Iida, Mitsuru Nenoi
Environmental contamination with radioactive materials caused by the Fukushima Dai-ichi Nuclear Power Plant (NPP) accident in 2011 raised a serious health concern among residents in Japan, and the demand for radiation experts who can handle the radiation-associated problems has increased. The Human Resources Development Center (HRDC) of the National Institute of for Quantum and Radiological Science and Technology in Japan has offered a variety of training programs covering a wide range of technologies associated with radiation since 1959...
July 2017: Health Physics
https://www.readbyqxmd.com/read/28542009/interpretation-of-urinary-excretion-data-from-plutonium-wound-cases-treated-with-dtpa-application-of-different-models-and-approaches
#9
Deepesh Poudel, Luiz Bertelli, John A Klumpp, Tom L Waters
After a chelation treatment, assessment of intake and doses is the primary concern of an internal dosimetrist. Using the urinary excretion data from two actual wound cases encountered at Los Alamos National Laboratory (LANL), this paper discusses several methods that can be used to interpret intakes from the urinary data collected after one or multiple chelation treatments. One of the methods uses only the data assumed to be unaffected by chelation (data collected beyond 100 d after the last treatment). This method, used by many facilities for official dose records, was implemented by employing maximum likelihood analysis and Bayesian analysis methods...
July 2017: Health Physics
https://www.readbyqxmd.com/read/28542007/uranium-mining-and-norm-in-north-america-some-perspectives-on-occupational-radiation-exposure
#10
Steven H Brown, Douglas B Chambers
All soils and rocks contain naturally occurring radioactive materials (NORM). Many ores and raw materials contain relatively elevated levels of natural radionuclides, and processing such materials can further increase the concentrations of naturally occurring radionuclides. In the U.S., these materials are sometimes referred to as technologically-enhanced naturally occurring radioactive materials (TENORM). Examples of NORM minerals include uranium ores, monazite (a source of rare earth minerals), and phosphate rock used to produce phosphate fertilizer...
July 2017: Health Physics
https://www.readbyqxmd.com/read/28536392/personalized-dosimetry-for-radionuclide-therapy-using-molecular-imaging-tools
#11
REVIEW
Michael Ljungberg, Katarina Sjögreen Gleisner
For treatment of systemic malignancies, when external radiation therapy is not applicable, radionuclide therapy can be an alternative. In this form of therapy, radionuclides are administered to the patient, often in a form where the radionuclide is labelled to a molecule that plays the active part in the localization of the tumor. Since the aim is to impart lethal damage to tumor cells while maintaining possible side-effects to normal tissues at tolerable levels, a proper and accurate personalized dosimetry should be a pre-requisite...
November 15, 2016: Biomedicines
https://www.readbyqxmd.com/read/28536067/relationship-between-quantitative-and-descriptive-methods-of-studying-blood-flow-through-intrapulmonary-arteriovenous-anastomoses-during-exercise
#12
Joseph W Duke, Jonathan E Elliott, Steven S Laurie, Thomas Voelkel, Igor M Gladstone, Mathews B Fish, Andrew T Lovering
Several methods exist to study intrapulmonary arteriovenous anastomoses (IPAVA) in humans. Transthoracic saline contrast echocardiography (TTSCE), i.e., bubble scores, is minimally-invasive, but cannot be used to quantify the magnitude of blood flow through IPAVA (QIPAVA). Radiolabeled macroaggregates of albumin ((99m)Tc-MAA) have been used to quantify QIPAVA in humans, but this requires injection of radioactive particles. Previous work has shown agreement between (99m)Tc-MAA and TTSCE, but this has not been tested simultaneously in the same group of subjects...
May 20, 2017: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/28535990/intravenous-and-intratumoral-injection-of-pluronic-p94-the-effect-of-administration-route-on-biodistribution-and-tumor-retention
#13
C Santini, A Arranja, A G Denkova, F Schosseler, K Morawska, P Dubruel, E Mendes, M de Jong, M Bernsen
Pluronics P94 are block-copolymer showing prolonged circulation time and tumor-cell internalization in vitro, suggesting a potential for tumor accumulation and as a drug carrier. Here we report the results of the radiolabeled-P94 unimers (P94-(111)In-DTPA) on tumor uptake/retention and biodistribution after intravenous and intratumoral administration injection to tumor-bearing mice. Intravenous administration results in a high radioactive signal in the liver; while in tumor and other healthy tissues only little levels of radioactivity could be measured...
May 20, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28535633/-radioactive-particles-implantation-treatment-technology-management-specification-interpretation-and-clinical-application-of-quality-control-index
#14
X K Hu, F J Zhang
No abstract text is available yet for this article.
May 23, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28534379/dosimetry-study-on-radioactive-particle-brachytherapy-in-oral-carcinoma
#15
Zhang Jie, Meng Jian, Zhuang Qianwei, Li Zhiping
PURPOSE: To investigate the therapeutic effects of different doses of (125)I radioactive particle brachytherapy on oral cancer. METHODS: Between September 2012 and September 2015, 78 patients with oral cancer who received (125)I radioactive particle brachytherapy for the first time in our hospital were enrolled in this study. Patients were divided into high dose (≥3) and low dose (<3) groups. The treatment outcome, serum tumor marker levels and the expression levels of autophagy and apoptotic genes in tumor cells were compared between groups...
March 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/28533936/synthesis-and-evaluation-of-64-cu-psma-617-targeted-for-prostate-specific-membrane-antigen-in-prostate-cancer
#16
Can Cui, Masayuki Hanyu, Akiko Hatori, Yiding Zhang, Lin Xie, Tomoya Ohya, Masami Fukada, Hisashi Suzuki, Kotaro Nagatsu, Cuiping Jiang, Rui Luo, Guoqiang Shao, Mingrong Zhang, Feng Wang
We radiolabeled a ligand, PSMA-617, of prostate-specific membrane antigen (PSMA) with copper-64 ((64)Cu), to evaluate the metabolism, biodistribution, and potential of [(64)Cu]PSMA-617 for PET imaging of prostate cancer. [(64)Cu]PSMA-617 was synthesized by heating PSMA-617 with [(64)Cu]CuCl2 in buffer solution at 90°C for 5 min. In vitro uptake was determined in two cell lines of prostate cancer. In vivo regional distributions were determined in normal and tumor-bearing mice. High radiolabeling efficiency of (64)Cu for PSMA-617 yielded [(64)Cu]PSMA-617 with >99% radiochemical purity...
2017: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28533801/computed-tomography-guided-implantation-of-125-i-seeds-brachytherapy-for-recurrent-multiple-pulmonary-oligometastases-initial-experience-and-results
#17
Jie Li, Lijuan Zhang, Wenhuan Xu, Teng Wang, Leyuan Zhou, Qigen Xie, Weiguo Wang, Yanyan Hua
PURPOSE: To retrospectively evaluate the efficacy and safety of computed tomography (CT)-guided percutaneous interstitial brachytherapy using (125)I radioactive seeds for multiple pulmonary metastatic tumors. MATERIAL AND METHODS: Between September 2013 and December 2015, 22 patients with multiple pulmonary metastases, who after conventional chemotherapy and trans-arterial chemoembolization (TACE) therapy were considered unable to withstand stereotactic body radiation therapy (SBRT), received CT-guided (125)I brachytherapy...
April 2017: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/28533637/development-and-validation-of-the-suprathreshold-stochastic-resonance-based-image-processing-method-for-the-detection-of-abdomino-pelvic-tumor-on-pet-ct-scans
#18
Kartik Saroha, Anil Kumar Pandey, Param Dev Sharma, Abhishek Behera, Chetan Patel, Chandrashekhar Bal, Rakesh Kumar
PURPOSE: The detection of abdomino-pelvic tumors embedded in or nearby radioactive urine containing 18F-FDG activity is a challenging task on PET/CT scan. In this study, we propose and validate the suprathreshold stochastic resonance-based image processing method for the detection of these tumors. METHODS: The method consists of the addition of noise to the input image, and then thresholding it that creates one frame of intermediate image. One hundred such frames were generated and averaged to get the final image...
April 2017: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/28533634/estimation-of-whole-body-radiation-exposure-to-nuclear-medicine-personnel-during-synthesis-of-177-lutetium-labeled-radiopharmaceuticals
#19
Geetanjali Arora, Rajesh Mishra, Praveen Kumar, Madhav Yadav, Sanjana Ballal, Chandrasekhar Bal, Nishikant Avinash Damle
PURPOSE OF THE STUDY: With rapid development in the field of nuclear medicine therapy, radiation safety of the personnel involved in synthesis of radiopharmaceuticals has become imperative. Few studies have been done on estimating the radiation exposure of personnel involved in the radio labeling of (177)Lu-compounds in western countries. However, data from the Indian subcontinent are limited. We have estimated whole body radiation exposure to the radiopharmacist involved in the labeling of: (177)Lu-DOTATATE, (177)Lu-PSMA-617, and (177)Lu-EDTMP...
April 2017: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/28532684/quantitative-determination-of-testosterone-levels-with-biolayer-interferometry
#20
Hao Zhang, Wei Li, Hong Luo, Guangming Xiong, Yuanhua Yu
Natural and synthetic steroid hormones are widely spread in the environment and are considered as pollutants due to their endocrine activities, even at low concentrations, which are harmful to human health. To detect steroid hormones in the environment, a novel biosensor system was developed based on the principle of biolayer interferometry. Detection is based on changes in the interference pattern of white light reflected from the surface of an optical fiber with bound biomolecules. Monitoring interactions between molecules does not require radioactive, enzymatic, or fluorescent labels...
May 19, 2017: Chemico-biological Interactions
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