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https://www.readbyqxmd.com/read/29667600/is-eye-lens-dosimetry-needed-in-nuclear-medicine
#1
Malgorzata Wrzesien, Leszek Krolicki, Lukasz Albiniak, Jerzy Olszewski
INTRODUCTION: The specificity of personnel exposure, which distinguishes nuclear medicine, is associated with the form of the radiation source used, and this often requires performing manual procedures while using radioactive isotopes. The variety of radionuclides and medical procedures, and the yearly increase in the number of patients, as well as the change of the individual dose limit for the lens of the eye from a value of 150 mSv per year to a level of 20 mSv, means that issues of eye lens routine dosimetry become interesting from the radiation protection point of view...
April 18, 2018: Journal of Radiological Protection: Official Journal of the Society for Radiological Protection
https://www.readbyqxmd.com/read/29667307/reduction-of-seed-motion-using-a-bio-absorbable-polymer-coating-during-permanent-prostate-brachytherapy-using-a-mick-applicator-technique
#2
Gregory R Warrell, Yan Xing, Tarun K Podder, Bryan J Traughber, Rodney J Ellis
PURPOSE: The addition of a braided bio-absorbable vicryl coating to the surface of radioactive seeds used for low dose rate (LDR) prostate brachytherapy is intended to reduce the incidence of seed movement and migration. Here, we present a single-institution study of the frequency and severity of seed slippage (initial seed movement) of coated seeds in comparison with uncoated seeds. METHODS: Forty-seven patients received permanent prostate brachytherapy, with either coated (n = 26) or uncoated (n = 21) seeds...
April 17, 2018: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/29666303/gallium-67-68-labeled-antibody-fragments-for-immuno-spect-pet-show-low-renal-radioactivity-without-loss-of-tumor-uptake
#3
Tomoya Uehara, Miki Yokoyama, Hiroyuki Suzuki, Hirofumi Hanaoka, Yasushi Arano
PURPOSE: This study was undertaken to evaluate the renal radioactivity levels of a newly designed 67 Ga-labeled antibody fragment with a linkage cleaved by enzymes present on the brush border membrane (BBM) lining the lumen of the renal tubule. EXPERIMENTAL DESIGN: 67 Ga-labeled S-2-(4-isothiocyanatobenzyl)-1,4,7-triazacyclononane-1,4,7-triacetic acid (SCN-Bn-NOTA) was conjugated with an antibody Fab fragment through a Met-Val-Lys linkage (67 Ga-NOTA-MVK-Fab) considering that a Met-Val sequence is a substrate of enzymes on the renal BBM and 67 Ga-NOTA-Met is excreted from the kidney into the urine...
April 17, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29665768/support-to-triage-and-public-risk-perception-considering-long-term-response-to-a-cs-137-radiological-dispersive-device-scenario
#4
Cristiane Ps Andrade, Cláudio J Souza, Eduardo Sn Camerini, Isabela S Alves, Hélio C Vital, Matthew Jf Healy, Edson Ramos De Andrade
A radiological dispersive device (RDD) spreads radioactive material, complicates the treatment of physical injuries, raises cancer risk, and induces disproportionate fear. Simulating such an event enables more effective and efficient utilization of the triage and treatment resources of staff, facilities, and space. Fast simulation can give detail on events in progress or future events. The resources for triage and treatment of contaminated trauma victims can differ for pure exposure individuals, while discouraging the "worried well" from presenting in the crisis phase by media announcement would relieve pressure on hospital facilities...
January 1, 2018: Toxicology and Industrial Health
https://www.readbyqxmd.com/read/29665644/biodistribution-of-free-and-encapsulated-99m-tc-fluconazole-in-an-infection-model-induced-by-candida-albicans
#5
Danielle Nogueira de Assis, Raquel Silva Araújo, Leonardo Lima Fuscaldi, Simone Odília Antunes Fernandes, Vanessa Carla Furtado Mosqueira, Valbert Nascimento Cardoso
BACKGROUND: Candida spp is an etiologic agent of fungal infections in hospitals and resistance to treatment with antifungals has been extensively reported. Thus, it is very important to develop formulations that increase effectiveness with low toxicity. In this sense, nanocarriers have been investigated, once they modify drug biodistribution profile. Thus, this study aimed to evaluate the biodistribution of free and encapsulated 99m Tc-fluconazole into nanocapsules (NCs) in an experimental immunosuppressed murine model of Candida albicans infection...
March 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29664794/positive-surgical-margins-in-favorable-stage-differentiated-thyroid-cancer
#6
Catherine E Mercado, Peter A Drew, Christopher G Morris, Peter T Dziegielewski, William M Mendenhall, Robert J Amdur
OBJECTIVE: The significance of positive margin in favorable-stage well-differentiated thyroid cancer is controversial. We report outcomes of positive-margin patients with a matched-pair comparison to a negative-margin group. MATERIALS AND METHODS: A total of 25 patients with classic-histology papillary or follicular carcinoma, total thyroidectomy +/- node dissection, stage T1-3N0-1bM0, positive surgical margin at primary site, adjuvant radioactive iodine (I-131), and age older than 18 years were treated between 2003 and 2013...
April 16, 2018: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29662563/-123-i-labeled-oxldl-is-widely-distributed-throughout-the-whole-body-in-mice
#7
Atushi Nakano, Hidekazu Kawashima, Yoshinori Miyake, Tsutomu Zeniya, Akihide Yamamoto, Kazuhiro Koshino, Takashi Temma, Tetsuya Fukuda, Yoshiko Fujita, Akemi Kakino, Shigehiko Kanaya, Tatsuya Sawamura, Hidehiro Iida
Purpose: Oxidized low-density lipoprotein (oxLDL) plays a key role in endothelial dysfunction, vascular inflammation, and atherogenesis. The aim of this study was to assess blood clearance and in vivo kinetics of radiolabeled oxLDL in mice. Methods: We synthesized 123 I-oxLDL by the iodine monochloride method, and performed an uptake study in CHO cells transfected with lectin-like oxLDL receptor-1 (LOX-1). In addition, we evaluated the consistency between the 123 I-oxLDL autoradiogram and the fluorescence image of DiI-oxLDL after intravenous injection for both spleen and liver...
April 2018: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29662476/improvement-of-the-uranium-sequestration-ability-of-a-chlamydomonas-sp-chlsp-strain-isolated-from-extreme-uranium-mine-tailings-through-selection-for-potential-bioremediation-application
#8
Beatriz Baselga-Cervera, Julia Romero-López, Camino García-Balboa, Eduardo Costas, Victoria López-Rodas
The extraction and processing of uranium (U) have polluted large areas worldwide, rendering anthropogenic extreme environments inhospitable to most species. Noticeably, these sites are of great interest for taxonomical and applied bioprospection of extremotolerant species successfully adapted to U tailings contamination. As an example, in this work we have studied a microalgae species that inhabits extreme U tailings ponds at the Saelices mining site (Salamanca, Spain), characterized as acidic (pH between 3 and 4), radioactive (around 4 μSv h-1 ) and contaminated with metals, mainly U (from 25 to 48 mg L-1 ) and zinc (from 17 to 87 mg L-1 )...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29660373/selenium-regulated-hierarchy-of-human-selenoproteome-in-cancerous-and-immortalized-cells-lines
#9
Zahia Touat-Hamici, Anne-Laure Bulteau, Juliusz Bianga, Hélène Jean-Jacques, Joanna Szpunar, Ryszard Lobinski, Laurent Chavatte
BACKGROUND: Selenoproteins (25 genes in human) co-translationally incorporate selenocysteine using a UGA codon, normally used as a stop signal. The human selenoproteome is primarily regulated by selenium bioavailability with a tissue-specific hierarchy. METHODS: We investigated the hierarchy of selenoprotein expression in response to selenium concentration variation in four cell lines originating from kidney (HEK293, immortalized), prostate (LNCaP, cancer), skin (HaCaT, immortalized) and liver (HepG2, cancer), using complementary analytical methods...
April 13, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29659943/cooperation-process-between-a-local-government-and-experts-in-official-voluntary-decontamination-of-environmental-radioactivity
#10
Takeshi Iimoto, Hirofumi Fujii, Seiichi Someya, Hajime Matsuzawa, Yukihide Yanagawa, Kiyoshi Kunii
Kashiwa city, inside the Tokyo metropolitan area and located ~200 km south of the Fukushima Dai-ichi Nuclear Power Plant, received a raised environmental ambient radiation dose due to the disaster relative to the rest of area. In this paper, the challenging process of the official voluntary decontamination activity in Kashiwa city, Chiba prefecture, which was carried out with strong cooperation between a local government and experts, is described and reviewed in terms of the effectiveness of the radiation protection...
April 6, 2018: Journal of Radiation Research
https://www.readbyqxmd.com/read/29659324/montelukast-attenuates-radioactive-i131-induced-pulmonary-damage-on-rats
#11
Arif Osman Tokat, Aylin Akbulut, Deniz Billur, Gokhan Koca, Pinar Bayram, Serdar Kuru, Sezgin Karasu, Suheyla Aydogmus, Hüseyin Cakmak, Sengul Ozmert, Meliha Korkmaz
PURPOSE: Radioactive I131 (RAI) therapy is a standard method to ablate the remnant thyroidal tissue after total thyroidectomy and its metastases in differentiated thyroid carcinomas, however, I131 also accumulates in non-thyroidal tissue, which may cause adverse effects and limit the I131 dose required for treatment. We hypothesized that montelukast, a known agent with anti-inflammatory and anti-oxidant properties, would ameliorate the radiation-induced histopathological characteristics such as pneumonitis and fibrosis in rat lungs after RAI...
April 16, 2018: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/29659319/disposition-of-tris-4-chlorophenyl-methanol-and-tris-4-chlorophenyl-methane-in-male-and-female-harlan-sprague-dawley-rats-and-b6c3f1-n-mice-following-oral-and-intravenous-administration
#12
Natasha Catlin, Suramya Waidyanatha, Sherry R Black, James Mathews, Rodney W Snyder, Purvi Patel, Scott Watson, Timothy R Fennell
1. Tris(4-chlorophenyl)methane (TCPME) and Tris(4-chlorophenyl)methanol (TCPMOH) have been detected in various biota and human tissues. 2. The current studies were undertaken to investigate the disposition and metabolism of TCPME and TCPMOH in rats and mice. 3. [14 C]TCPME was well absorbed (≥ 66%) in male rats and mice following a single oral administration of 1, 10, or 100 mg/kg. The excretion of [14 C]TCPME-derived radioactivity in urine (≤ 2.5%) and feces (≤18%) was low. The administered dose was retained in tissues (≥ 64%) with adipose containing the highest concentrations...
April 16, 2018: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
https://www.readbyqxmd.com/read/29658363/therapy-of-cervical-cancer-using-131-i-labeled-nanoparticles
#13
Wei Li, Danyang Sun, Ning Li, Yiming Shen, Yiming Hu, Jian Tan
Objective To evaluate the effectiveness of two kinds of Arg-Gly-Asp (RGD)-targeted 131 I-containing nanoliposomes for the treatment of cervical cancer in vitro and in vivo. Methods The nanoparticle liposomes designated RGD-131 I-tyrosine peptide chain (TPC)-L and 131 I-RGD-L were prepared. The emulsion solvent evaporation method was used to encapsulate the polypeptide into liposomes. The quantity of entrapped polypeptide was measured using UV spectrophotometry. The labeling rates, radiochemical purities, and total radioactivities were measured using paper chromatography...
January 1, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29658049/a-simple-microfluidic-platform-for-rapid-and-efficient-production-of-the-radiotracer-18-f-fallypride
#14
Xin Zhang, Fei Liu, Karla-Anne Knapp, Michael L Nickels, H Charles Manning, Leon M Bellan
Herein, we report the development of a simple, high-throughput and efficient microfluidic system for synthesizing radioactive [18F]fallypride, a PET imaging radiotracer widely used in medical research. The microfluidic chip contains all essential modules required for the synthesis and purification of radioactive fallypride. The radiochemical yield of the tracer is sufficient for multiple animal injections for preclinical imaging studies. To produce the on-chip concentration and purification columns, we employ a simple "trapping" mechanism by inserting rows of square pillars with predefined gaps near the outlet of microchannel...
April 16, 2018: Lab on a Chip
https://www.readbyqxmd.com/read/29656230/multifractal-approach-for-delineating-uranium-anomalies-related-to-phosphatic-deposits-in-area-3-northern-palmyrides-syria
#15
Jamal Asfahani
Multifractal Concentration-Number (C-N) modeling approach has been developed and applied to Airborne Gamma Spectrometry (AGS) data related to Area-3, Northern Palmyrides, Syria. The application of the multifractal approach basically aimed at separating uranium anomalies from background. The AGS technique has been applied for uranium exploration in Syria, where four radioactive parameters were recorded, T.C, eU, eTh, and K%. Log-log plots practiced on those radioactive variables indicate the presence of different uranium anomaly ranges...
March 19, 2018: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/29655424/simultaneous-elastase-hyaluronidase-and-collagenase-capillary-electrophoresis-based-assay-application-to-evaluate-the-bioactivity-of-the-red-alga-jania-rubens
#16
Syntia Fayad, Mona Tannoury, Philippe Morin, Reine Nehmé
There have been many efforts to search for affordable and efficient cosmetic ingredients from natural sources and to evaluate their bioactivities using eco-responsible tools. Hyaluronidase, elastase and collagenase are responsible for the degradation of the main components of the extracellular matrix, namely the hyaluronic acid, elastin and collagen, respectively. The aim of this work was to develop a single capillary electrophoresis method to monitor simultaneously the activities of these three enzymes, without reactant immobilization or radioactivity use...
August 22, 2018: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29653355/monte-carlo-method-for-gamma-spectrometry-based-on-geant4-toolkit-efficiency-calibration-of-be6530-detector
#17
Guembou Shouop Cebastien Joel, Ndontchueng Moyo Maurice, Nguelem Mekongtso Eric Jilbert, Motapon Ousmanou, Strivay David
The combination of gamma-ray spectrometry, the development of related Monte Carlo method and the GEANT4 (GEometry ANd Tracking) toolkit have been developed for gamma spectrometry simulation. The main objective was to validate simulation models of broad energy germanium (BEGe) detector geometry built in our laboratory (BE6530 model). Monte Carlo simulation of the geometry of BE6530 detector for efficiency calibration was carried out with GEANT4 toolkit. The simulated efficiencies curves using MC were compared with experimental results...
April 10, 2018: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/29653300/comparison-of-solvent-extraction-and-extraction-chromatography-resin-techniques-for-uranium-isotopic-characterization-in-high-level-radioactive-waste-and-barrier-materials
#18
Santiago Hurtado-Bermúdez, María Villa-Alfageme, José Luis Mas, María Dolores Alba
The development of Deep Geological Repositories (DGP) to the storage of high-level radioactive waste (HLRW) is mainly focused in systems of multiple barriers based on the use of clays, and particularly bentonites, as natural and engineered barriers in nuclear waste isolation due to their remarkable properties. Due to the fact that uranium is the major component of HLRW, it is required to go in depth in the analysis of the chemistry of the reaction of this element within bentonites. The determination of uranium under the conditions of HLRW, including the analysis of silicate matrices before and after the uranium-bentonite reaction, was investigated...
April 5, 2018: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/29652748/the-scintigraphic-biodistribution-and-histopathological-evaluation-of-the-effect-of-experimental-131i-administration-on-the-gastrointestinal-system-and-the-demonstration-of-the-na-i-symporter-by-immunohistochemistry-in-rats
#19
Rahsan Yilmaz, Nihat Yumusak, Murat Sadic, Hasan I Atilgan, Meliha Korkmaz, Faruk Bozkaya
OBJECTIVE: The aim of this study was to investigate histopathological changes and biodistribution of iodine-131 (I) in the gastrointestinal system (GIS) and also Na/I Symporter (NIS) presence by immunohistochemically in the experimental treatment of rats with radioactive iodine (RAI). MATERIALS AND METHODS: Rats were divided into experimental and control groups as random early group 2 (24 h), intermediate group 3 (3 weeks), and late period group 4 (3 months). Experimental groups were administered 100 MBq (∼3 mCi, 12 mCi/kg) by orogastric route with orogastric tube...
April 12, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29652492/evidence-for-the-heaviest-expected-halide-species-in-aqueous-solution-at-by-electromobility-measurements
#20
Ning Guo, Fabien Pottier, Jean Aupiais, Cyrille Alliot, Gilles Montavon, Julie Champion
At- (astatide) is commonly expected to be the heaviest halide in the halogen group. However, there is no proof for the existence of this -1 charged species. Furthermore, investigations with astatine are restricted by its specific radioactive properties, which entail working at ultratrace concentrations (typically less than 10-10 M). In this work, an especially built electromigration device is applied to obtain information about the charge/size ratio characterizing an ion in aqueous solution. An anionic At species is observed in reducing conditions...
April 13, 2018: Inorganic Chemistry
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