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DLPFC cacna1c

Ilaria Guella, Adolfo Sequeira, Brandi Rollins, Linda Morgan, Federica Torri, Theo G M van Erp, Richard M Myers, Jack David Barchas, Alan F Schatzberg, Stanley J Watson, Huda Akil, William E Bunney, Steven G Potkin, Fabio Macciardi, Marquis P Vawter
MicroRNAs (miRNAs) are small non-coding RNAs that act as potent regulators of gene expression. A recent GWAS reported the rs1625579 SNP, located downstream of miR-137, as the strongest new association with schizophrenia [Ripke S, Sanders AR, Kendler KS, Levinson DF, Sklar P, Holmans PA, et al. Genome-wide association study identifies five new schizophrenia loci. Nat Genet 2011;43:969-76.]. Prior to this GWAS finding, a schizophrenia imaging-genetic study found miR-137 target genes significantly enriched for association with activation in the dorsolateral prefrontal cortex (DLPFC) [Potkin SG, Macciardi F, Guffanti G, Fallon JH, Wang Q, Turner JA, et al...
September 2013: Journal of Psychiatric Research
Frieder M Paulus, Johannes Bedenbender, Sören Krach, Martin Pyka, Axel Krug, Jens Sommer, Miriam Mette, Markus M Nöthen, Stephanie H Witt, Marcella Rietschel, Tilo Kircher, Andreas Jansen
BACKGROUND: Genome-wide association studies have identified the rs1006737 single nucleotide polymorphism (SNP) in the CACNA1C gene as a susceptibility locus for schizophrenia and bipolar disorder. On the neural systems level this association is explained by altered functioning of the dorsolateral prefrontal cortex (DLPFC) and the hippocampal formation (HF), brain regions also affected by mental illness. In the present study we investigated the association of rs1006737 genotype with prefrontal activation and fronto-hippocampal connectivity...
April 2014: Human Brain Mapping
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