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V Herceg, S Adriouach, K Janikowska, E Allémann, N Lange, A Babič
Treatment of cancer cells by clinically approved hexyl ester of 5-aminolevulinic acid (ALA-Hex) induces accumulation of fluorescent porphyrins in tumors. This allows fluorescence photodiagnosis (PD) of bladder cancer by blue light illumination. However, PD of other cancers is hampered by acute toxicity of the compound limiting its use to local applications. We have designed and synthesized a new prodrug of ALA-Hex that tackles the stability-activity paradox of amino-modified 5-ALA prodrugs. The glucuronide prodrug Glu-ALA-Hex demonstrates excellent stability under physiological conditions and activation in the presence of the target enzyme...
March 30, 2018: Bioorganic Chemistry
Giuseppe Catapano, Francesco Giovanni Sgulò, Vincenzo Seneca, Giuseppina Iorio, Matteo de Notaris, Giuseppe di Nuzzo
Over the last years, fluorescence-based technology has begun an emergent intraoperative method for diagnostic confirmation of brain tumor tissue in stereotactic needle biopsy. However, the actual level of evidence is quite low, especially about fluorescein sodium (FL) application. This method needs to be further validated and better analyzed about its impact in clinical practice. Retrospective analysis of 11 cases with contrast-enhancing brain tumors, underwent awake stereotactic needle biopsy with intraoperative FL assistance (group 1), was verified under the operative microscope filter...
January 30, 2018: Neurosurgical Review
Andrej Babič, V Herceg, E Bastien, H-P Lassalle, L Bezdetnaya, Norbert Lange
Protoporphyrin IX (PpIX) as natural photosensitizer derived from administration of 5-aminolevulinic acid (5-ALA) has found clinical use for photodiagnosis and photodynamic therapy of several cancers. However, broader use of 5-ALA in oncology is hampered by its charge and polarity that result in its reduced capacity for passing biological barriers and reaching the tumor tissue. Advanced drug delivery platforms are needed to improve the biodistribution of 5-ALA. Here, we report a new approach for the delivery of 5-ALA...
January 11, 2018: Nanoscale Research Letters
Shaimaa Elbassiouny, Maha Fadel, Tarek Elwakeel, Mahmoud Saber
AIM OF THE STUDY: Exploring whether the formulation of ALA in nano-stealth liposomes would inflict its photodiagnostic effectiveness. The present study represents ALA in nano-stealth liposomes as well as in conventional nanoliposomes in order to be used for photodiagnosis of parathyroid glands intraoperatively. MATERIALS AND METHODS: Preparation of ALA nanovesicles and characterization for the drug encapsulation%, vesicle size, Zeta potential, in vitro drug release profile and stability...
November 15, 2017: Photodiagnosis and Photodynamic Therapy
Henri Azaïs, Geoffroy Canlorbe, Yohan Kerbage, Anne Grabarz, Pierre Collinet, Serge Mordon
Image-guided surgery is a relevant way to reduce surgical morbidity and maximize cytoreductive surgery approach especially in ovarian cancer. Sentinel lymph node detection is a promising approach to avoid radical lymph node dissection and is slightly becoming standard in daily practice in endometrial and cervical cancer surgery even if it needs to be evaluated more precisely. Regarding carcinomatosis of ovarian origin, detection and treatment of microscopic disease could be appropriate to avoid local recurrences...
November 10, 2017: Future Oncology
Viktorija Herceg, Norbert Lange, Eric Allémann, Andrej Babič
5-aminolevulinc acid (5-ALA)-based photodynamic therapy (PDT) and photodiagnosis (PD) present many advantages over treatments with conventional photosensitizers (PS). It offers great tumor specificity, reduced photosensitivity reactions caused by PS accumulation in non-targeted tissues and also inherent PS metabolism into endogenous non-fluorescent heme. However, chemical instability, low bioavailability and poor pharmacokinetic profile limit systemic efficacy of 5-ALA. Here, we present a comprehensive in vitro evaluation of novel phosphatase-sensitive prodrugs of 5-ALA...
June 2017: Journal of Photochemistry and Photobiology. B, Biology
(no author information available yet)
No abstract text is available yet for this article.
March 2017: Photodiagnosis and Photodynamic Therapy
Yunjie Zhang
No abstract text is available yet for this article.
March 2017: Photodiagnosis and Photodynamic Therapy
Yonghui Xia, Yu Su, Ian Hin Yat Wong, Xiaoli Ma, Rui Hua
Idiopathic retinal vasculitis, aneurysms, and neuroretinitis (IRVAN) syndrome is a disease characterized by multiple retinal macroaneurysms, neuroretinitis and peripheral capillary non-perfusion, leading to irreversible visual loss. It includes five stages and has previously been rarely reported. IRVAN syndrome is especially rare in Asia. In this report, we describe laser diagnosis and therapy in an Asian patient with IRVAN syndrome over two years of follow-up. We observed non-perfusion retina and dilated retinal capillaries in the contralateral eye...
December 2016: Photodiagnosis and Photodynamic Therapy
Chung-Hsing Chang, Yu-Hsuan Lin, Cheng-Ru Li, Chun-Ming Chang, Chih-Wei Hung, Han-Chao Chang
Dermatological photodynamic therapy (DPDT) involves using systematic photosensitizers in combination with light irradiation treatment to eliminate cancer cells. Therefore, a noninvasive fluorescence photodiagnosis system is critical in DPDT for diagnosing target tissues and demarcating the margin of normal tissues. This study proposes a 375-nm ring LED light module in fluorescence imaging for DPDT applications. Image reproducibility (I.R.) and image interference (I.I.) analysis were performed. The results showed that the I...
September 2016: Photodiagnosis and Photodynamic Therapy
Lais Alonso, Renato N Sampaio, Thalita F M Souza, Rodrigo C Silva, Newton M Barbosa Neto, Anderson O Ribeiro, Antonio Alonso, Pablo J Gonçalves
The present work reports the synthesis, photophysical and photochemical characterization and photodynamic evaluation of zinc, aluminum and metal free-base tetracarboxy-phthalocyanines (ZnPc, AlPc and FbPc, respectively). To evaluate the possible application of phthalocyanines as a potential photosensitizer the photophysical and photochemical characterization were performed using aqueous (phosphate-buffered solution, PBS) and organic (dimethyl sulfoxide, DMSO) solvents. The relative lipophilicity of the compounds was estimated by the octanol-water partition coefficient and the photodynamic activity evaluated through the photooxidation of a protein and photohemolysis...
August 2016: Journal of Photochemistry and Photobiology. B, Biology
Gantumur Battogtokh, Young Tag Ko
The objective of this study was to develop an active-targeted, pH-responsive albumin-photosensitizer-incorporated graphene oxide nanocomplex as an image-guided theranostic agent for dual therapies. Herein, bovine serum albumin (BSA)-cis-aconityl pheophorbide-a (c-PheoA) conjugate was complexed with graphene oxide (GO) at ratios of 1:1, 1:0.5, and 1:0.1 with the mean hydrodynamic diameter of the resulting complex being 100-200nm. Further, with the 1:0.5 ratio, we developed a folate-BSA-c-PheoA conjugate:GO complex incorporated free PheoA (PheoA+GO:FA-BSA-c-PheoA NC) with a mean hydrodynamic diameter of 182...
July 28, 2016: Journal of Controlled Release: Official Journal of the Controlled Release Society
Yiyun Dong, Guoyu Zhou, Jinan Chen, Lingyue Shen, Zhao Jianxin, Qing Xu, Yulan Zhu
OBJECTIVE: This study investigated the efficacy and safety of a newly designed LED device used in photodiagnosis and photodynamic therapy of moderate to severe acne vulgaris in Chinese patients. METHODS: Forty-six patients with moderate to severe facial acne showing high degrees of fluorescence by ultraviolet light examination were illuminated during ALA-PDT with two wavelengths of light (543-548 nm, and 630±6 nm, respectively) after 2 h of incubation with ALA...
March 2016: Photodiagnosis and Photodynamic Therapy
Riccardo G Borroni, Stefania Barruscotti, Andrea Carugno, Vincenzo Barbaccia, Eloisa Arbustini, Valeria Brazzelli
BACKGROUND: Basal cell carcinoma (BCC) is the most frequent malignant tumor of the skin. The high prevalence of BCC, the risk of local recurrence, and the difficult clinical identification of the excision margins emphasize the importance of studying new approaches, ensuring complete surgical excision that allows preservation of normal tissue, especially for BCCs located on cosmetically important areas such as the mid face. Photodiagnosis (PD) is a pre-operative technique that allows a more accurate distinction of neoplastic lesions from surrounding healthy skin in vivo...
July 2015: Photodermatology, Photoimmunology & Photomedicine
M F Ugarte, L Chávarri, S Briz, V M Padrón, E García-Cuesta
The proposed system has been designed to identify dermatopathologies or to apply personalized phototherapy treatments. The system emits electromagnetic waves in different spectral bands in the range of visible and near infrared to irradiate the target (skin or any other object) to be spectrally characterized. Then, an imaging sensor measures the target response to the stimulus at each spectral band and, after processing, the system displays in real time two images. In one of them the value of each pixel corresponds to the more reflected wavenumber whereas in the other image the pixel value represents the energy absorbed at each band...
October 2014: Review of Scientific Instruments
T Horváth
No abstract text is available yet for this article.
2014: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
Tobias Kiesslich, Linda Helander, Romana Illig, Christian Oberdanner, Andrej Wagner, Herbert Lettner, Martin Jakab, Kristjan Plaetzer
Photodynamic therapy (PDT) and photodiagnosis based on the intracellular production of the photosensitizer protoporphyrin IX (PPIX) by administration of its metabolic precursor -aminolevulinic acid (ALA) achieved their breakthrough upon the clinical approval of MAL (ALA methyl ester) and HAL (ALA hexyl ester). For newly developed ALA derivatives or application in new tumor types, in vitro determination of PPIX formation involves multiparametric experiments covering variable pro-drug concentrations, medium composition, time points of analysis, and cell type(s)...
August 2014: Journal of Biomedical Optics
Slawomir G Kata, Ghulam Nabi, Sam Eljamel, Piotr Chlosta, Harry Moseley, Omar M Aboumarzouk
OBJECTIVE: To explain our use of photodynamic diagnostic ureterorenoscopy, we provide a detailed description of the choice of photosensitiser, equipment needed, a safety profile, and pointers on our technique. TECHNIQUE: Patients are given oral 5-aminolaevulinic acid (5-ALA) as a photosensitiser 3-4 h pre-operatively, and by using a Xenon blue light source, an eyepiece which blocks light below 450 nm which is fitted onto the ureterorenoscope, we are able to conduct a thorough photodiagnosis of the upper urinary tract...
2014: Urologia Internationalis
Janelle M Reyes-Goddard, Hugh Barr, Nicholas Stone
Raman spectroscopy is the measure of inelastic scatter and has been described since 1928. It is particularly useful for medical applications because the scattered radiation measured is unique for each biomolecule. The aim of this study was to review works published in Raman scattering and surface enhanced Raman scattering (SERS) on bodily fluids. The main Raman studies have concentrated on the detection of metabolites in the aqueous humour, urine and blood-based fluids and on drugs in the latter. Other bodily fluids are also studied, e...
September 2005: Photodiagnosis and Photodynamic Therapy
R R Allison, R E Cuenca, G H Downie, P Camnitz, B Brodish, C H Sibata
As local control is tantamount to cure in head and neck cancer, an aggressive regimen of surgery and radiation remains the standard of care for most patients. Despite significant technical advances, these treatments are highly morbid. Further, patients who fail treatment have limited salvage options. Photodynamic therapy (PDT) and photodiagnosis (PD) of head and neck cancer offer significant potential for improved outcomes in a myriad of clinical indications ranging from in situ to recurrent disease. However, despite promising results, these modalities remain at the fringe of head and neck treatment options...
September 2005: Photodiagnosis and Photodynamic Therapy
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