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https://www.readbyqxmd.com/read/28329845/spatiotemporal-progression-and-remission-of-lesions-in-the-rat-brain-following-acute-intoxication-with-diisopropylfluorophosphate
#1
Sílvia Sisó, Brad A Hobson, Danielle J Harvey, Donald A Bruun, Douglas J Rowland, Joel R Garbow, Pamela J Lein
Similar to organophosphate (OP) nerve agents, diisopropylfluorophosphate (DFP) rapidly and irreversibly inhibits acetylcholinesterase, leading to convulsions that can progress to status epilepticus (SE). However, in contrast to the OP nerve agents, the long-term consequences of DFP-induced SE are not well known. Thus, we characterized the spatiotemporal profile of neuropathology during the first two months following acute DFP intoxication. Adult, male Sprague Dawley rats administered pyridostigmine bromide (0...
March 7, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28329842/magnetic-resonance-imaging-reveals-progressive-brain-injury-in-rats-acutely-intoxicated-with-diisopropylfluorophosphate
#2
Brad A Hobson, Sílvia Sisó, Douglas J Rowland, Danielle J Harvey, Donald A Bruun, Joel R Garbow, Pamela J Lein
Acute intoxication with organophosphates (OPs) can trigger seizures that progress to status epilepticus, and survivors often exhibit chronic neuropathology, cognitive impairment, affective disorders and/or electroencephalographic abnormalities. Understanding how acute injury transitions to persistent neurological sequelae is critical to developing medical countermeasures for mitigating damage following OP-induced seizures. Here, we used in vivo magnetic resonance imaging (MRI) to monitor the spatiotemporal patterns of neuropathology for one month after acute intoxication with diisopropylfluorophosphate (DFP)...
March 7, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28266278/synthesis-and-preliminary-cytotoxicity-studies-of-1-1-4-5-dihydrooxazol-2-yl-1h-indazol-3-yl-3-phenylurea-and-3-phenylthiourea-derivatives
#3
Monika Wojciechowska, Łukasz Sitek, Aneta Sakowicz, Ewa Romejko, Piotr Szumlas, Martyna Korcz, Patrick J Bednarski, Franciszek Sączewski, Anita Kornicka
BACKGROUND: N-substituted 3-amino-1H-indazoles represent an interesting class of biologically active compounds. Among them, derivatives containing phenylurea moiety are of particular interest. Such compounds have been found to possess inhibitory activity against cancer cell growth. Additionally, various oxazoline-containing compounds have also been designed as potential anticancer agents. OBJECTIVE: The aim of this work was to obtain a new class of N-substituted 3-amino-1H-indazole derivatives with cytotoxic activity towards cancer cells...
March 6, 2017: Medicinal Chemistry
https://www.readbyqxmd.com/read/28121885/the-drivers-of-academic-success-in-cleft-and-craniofacial-centers-a-10-year-analysis-of-over-2000-publications
#4
Natalie M Plana, Jonathan P Massie, Marleigh J Stern, Michael Alperovich, Christopher M Runyan, David A Staffenberg, Leonidas G Koniaris, Barry H Grayson, J Rodrigo Diaz-Siso, Roberto L Flores
BACKGROUND: Cleft and craniofacial centers require significant investment by medical institutions, yet variables contributing to their academic productivity remain unknown. This study characterizes the elements associated with high academic productivity in these centers. METHODS: The authors analyzed cleft and craniofacial centers accredited by the American Cleft Palate-Craniofacial Association. Variables such as university affiliation; resident training; number of plastic surgery, oral-maxillofacial, and dental faculty; and investment in a craniofacial surgery, craniofacial orthodontics fellowship program, or both, were obtained...
February 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28113132/osseodensification-for-enhancement-of-spinal-surgical-hardware-fixation
#5
Christopher D Lopez, Adham M Alifarag, Andrea Torroni, Nick Tovar, J Rodrigo Diaz-Siso, Lukasz Witek, Eduardo D Rodriguez, Paulo G Coelho
Integration between implant and bone is an essential concept for osseous healing requiring hardware placement. A novel approach to hardware implantation, termed osseodensification, is described here as an effective alternative. 12 sheep averaging 65kg had fixation devices installed in their C2, C3, and C4 vertebral bodies; each device measured 4mm diameter×10mm length. The left-sided vertebral body devices were implanted using regular surgical drilling (R) while the right-sided devices were implanted using osseodensification drilling (OD)...
January 13, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28058722/cell-level-anatomical-characteristics-explain-high-mesophyll-conductance-and-photosynthetic-capacity-in-sclerophyllous-mediterranean-oaks
#6
José Javier Peguero-Pina, Sergio Sisó, Jaume Flexas, Jeroni Galmés, Ana García-Nogales, Ülo Niinemets, Domingo Sancho-Knapik, Miguel Ángel Saz, Eustaquio Gil-Pelegrín
Leaf mass per area (LMA) has been suggested to negatively affect the mesophyll conductance to CO2 (gm ), which is the most limiting factor for area-based photosynthesis (AN ) in many Mediterranean sclerophyll species. However, despite their high LMA, these species have similar AN to plants from other biomes. Variations in other leaf anatomical traits, such as mesophyll and chloroplast surface area exposed to intercellular air space (Sm /S and Sc /S), may offset the restrictions imposed by high LMA in gm and AN in these species...
January 6, 2017: New Phytologist
https://www.readbyqxmd.com/read/28005726/teaching-our-patients-and-residents-time-s-limitations-and-technology-s-answer
#7
J Rodrigo Diaz-Siso, Natalie M Plana, Patricia D Chibbaro, Joseph G McCarthy, Roberto L Flores
No abstract text is available yet for this article.
November 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/27933069/accumulation-and-secretion-of-coumarinolignans-and-other-coumarins-in-arabidopsis-thaliana-roots-in-response-to-iron-deficiency-at-high-ph
#8
Patricia Sisó-Terraza, Adrián Luis-Villarroya, Pierre Fourcroy, Jean-François Briat, Anunciación Abadía, Frédéric Gaymard, Javier Abadía, Ana Álvarez-Fernández
Root secretion of coumarin-phenolic type compounds has been recently shown to be related to Arabidopsis thaliana tolerance to Fe deficiency at high pH. Previous studies revealed the identity of a few simple coumarins occurring in roots and exudates of Fe-deficient A. thaliana plants, and left open the possible existence of other unknown phenolics. We used HPLC-UV/VIS/ESI-MS(TOF), HPLC/ESI-MS(ion trap) and HPLC/ESI-MS(Q-TOF) to characterize (identify and quantify) phenolic-type compounds accumulated in roots or secreted into the nutrient solution of A...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27816180/discrete-sliding-mode-controller-with-reaching-phase-elimination-for-tito-systems
#9
V D Hajare, A A Khandekar, B M Patre
Sliding mode control (SMC) is emerged as a powerful robust controller for the process control application. However, it does not posses robustness properties during reaching phase and suffers from chattering, which is undesirable. In this paper, a chatter free discrete sliding mode controller (DSMC) with reaching phase elimination is proposed. The issue of existence of reaching phase due to physical constraints such as saturation of actuating devices is also addressed. The two-input-two-output (TITO) system is decoupled into two single-input-single-output (SISO) systems using ideal decoupler...
November 2, 2016: ISA Transactions
https://www.readbyqxmd.com/read/27783706/investigation-of-multi-input-multi-output-robust-control-methods-to-handle-parametric-uncertainties-in-autopilot-design
#10
Coşku Kasnakoğlu
Some level of uncertainty is unavoidable in acquiring the mass, geometry parameters and stability derivatives of an aerial vehicle. In certain instances tiny perturbations of these could potentially cause considerable variations in flight characteristics. This research considers the impact of varying these parameters altogether. This is a generalization of examining the effects of particular parameters on selected modes present in existing literature. Conventional autopilot designs commonly assume that each flight channel is independent and develop single-input single-output (SISO) controllers for every one, that are utilized in parallel for actual flight...
2016: PloS One
https://www.readbyqxmd.com/read/27729905/metagenomics-of-thermophiles-with-a-focus-on-discovery-of-novel-thermozymes
#11
María-Eugenia DeCastro, Esther Rodríguez-Belmonte, María-Isabel González-Siso
Microbial populations living in environments with temperatures above 50°C (thermophiles) have been widely studied, increasing our knowledge in the composition and function of these ecological communities. Since these populations express a broad number of heat-resistant enzymes (thermozymes), they also represent an important source for novel biocatalysts that can be potentially used in industrial processes. The integrated study of the whole-community DNA from an environment, known as metagenomics, coupled with the development of next generation sequencing (NGS) technologies, has allowed the generation of large amounts of data from thermophiles...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27673543/computer-simulation-and-digital-resources-for-plastic-surgery-psychomotor-education
#12
J Rodrigo Diaz-Siso, Natalie M Plana, John T Stranix, Court B Cutting, Joseph G McCarthy, Roberto L Flores
Contemporary plastic surgery residents are increasingly challenged to learn a greater number of complex surgical techniques within a limited period. Surgical simulation and digital education resources have the potential to address some limitations of the traditional training model, and have been shown to accelerate knowledge and skills acquisition. Although animal, cadaver, and bench models are widely used for skills and procedure-specific training, digital simulation has not been fully embraced within plastic surgery...
October 2016: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/27663188/neuro-adaptive-backstepping-control-of-siso-non-affine-systems-with-unknown-gain-sign
#13
Zahra Ramezani, Mohammad Mehdi Arefi, Hassan Zargarzadeh, Mohammad Reza Jahed-Motlagh
This paper presents two neuro-adaptive controllers for a class of uncertain single-input, single-output (SISO) nonlinear non-affine systems with unknown gain sign. The first approach is state feedback controller, so that a neuro-adaptive state-feedback controller is constructed based on the backstepping technique. The second approach is an observer-based controller and K-filters are designed to estimate the system states. The proposed method relaxes a priori knowledge of control gain sign and therefore by utilizing the Nussbaum-type functions this problem is addressed...
September 20, 2016: ISA Transactions
https://www.readbyqxmd.com/read/27567682/facial-transplantation-knowledge-arrives-questions-remain
#14
COMMENT
J Rodrigo Diaz-Siso, Eduardo D Rodriguez
No abstract text is available yet for this article.
October 1, 2016: Lancet
https://www.readbyqxmd.com/read/27537880/through-wall-multiple-targets-vital-signs-tracking-based-on-vmd-algorithm
#15
Jiaming Yan, Hong Hong, Heng Zhao, Yusheng Li, Chen Gu, Xiaohua Zhu
Targets located at the same distance are easily neglected in most through-wall multiple targets detecting applications which use the single-input single-output (SISO) ultra-wideband (UWB) radar system. In this paper, a novel multiple targets vital signs tracking algorithm for through-wall detection using SISO UWB radar has been proposed. Taking advantage of the high-resolution decomposition of the Variational Mode Decomposition (VMD) based algorithm, the respiration signals of different targets can be decomposed into different sub-signals, and then, we can track the time-varying respiration signals accurately when human targets located in the same distance...
2016: Sensors
https://www.readbyqxmd.com/read/27516835/the-ever-evolving-state-of-the-art-a-look-back-at-the-aona-facial-reconstruction-and-transplantation-meetings
#16
J Rodrigo Diaz-Siso, Natalie M Plana, Paul N Manson, Eduardo D Rodriguez
Historically, periodic academic meetings held by surgical societies have set the stage for discussion and exchange of ideas, which in turn have led to advancement of clinical practices. Since 2007, the AONA State of the Art: Facial Reconstruction and Transplantation Meeting (FRTM) has been organized to provide a forum for specialists around the world to engage in open conversation about the approaches currently at the forefront of facial reconstruction. Review of registration data of FRTM iterations from 2007 to 2015 was performed...
September 2016: Craniomaxillofacial Trauma & Reconstruction
https://www.readbyqxmd.com/read/27511313/canine-nervous-system-lymphoma-subtypes-display-characteristic-neuroanatomical-patterns
#17
S Sisó, P Marco-Salazar, P F Moore, B K Sturges, W Vernau, E R Wisner, A W Bollen, P J Dickinson, R J Higgins
Primary and secondary nervous system involvement occurs in 4% and 5%-12%, respectively, of all canine non-Hodgkin lymphomas. The recent new classification of canine malignant lymphomas, based on the human World Health Organization classification, has been endorsed with international acceptance. This histological and immunocytochemical classification provides a unique opportunity to study the histologic anatomic distribution patterns in the central and peripheral nervous system of these defined lymphoma subtypes...
January 2017: Veterinary Pathology
https://www.readbyqxmd.com/read/27447489/spread-spectrum-based-energy-efficient-collaborative-communication-in-wireless-sensor-networks
#18
Anwar Ghani, Husnain Naqvi, Muhammad Sher, Muazzam Ali Khan, Imran Khan, Azeem Irshad
Wireless sensor networks consist of resource limited devices. Most crucial of these resources is battery life, as in most applications like battle field or volcanic area monitoring, it is often impossible to replace or recharge the power source. This article presents an energy efficient collaborative communication system based on spread spectrum to achieve energy efficiency as well as immunity against jamming, natural interference, noise suppression and universal frequency reuse. Performance of the proposed system is evaluated using the received signal power, bit error rate (BER) and energy consumption...
2016: PloS One
https://www.readbyqxmd.com/read/27410359/experimental-investigation-of-inter-core-crosstalk-tolerance-of-mimo-ofdm-oqam-radio-over-multicore-fiber-system
#19
Jiale He, Borui Li, Lei Deng, Ming Tang, Lin Gan, Songnian Fu, Perry Ping Shum, Deming Liu
In this paper, the feasibility of space division multiplexing for optical wireless fronthaul systems is experimentally demonstrated by implementing high speed MIMO-OFDM/OQAM radio signals over 20km 7-core fiber and 0.4m wireless link. Moreover, the impact of optical inter-core crosstalk in multicore fibers on the proposed MIMO-OFDM/OQAM radio over fiber system is experimentally evaluated in both SISO and MIMO configurations for comparison. The experimental results show that the inter-core crosstalk tolerance of the proposed radio over fiber system can be relaxed to -10 dB by using the proposed MIMO-OFDM/OQAM processing...
June 13, 2016: Optics Express
https://www.readbyqxmd.com/read/27402224/diagnostic-and-prognostic-significance-of-receptor-binding-cancer-antigen-expressed-on-siso-cells-in-lung-cancer-associated-pleural-effusion
#20
Jian Yang, Ying Zhu, Liangquan Wu, Wenyan Zhu, Xiuwei Zhang, Yang Yang, Chunhua Xu
OBJECTIVES: This study aimed to evaluate the diagnostic and prognostic value of pleural effusion levels of soluble receptor-binding cancer antigen expressed on SiSo cells (sRCAS1) in lung cancer patients with malignant pleural effusion (MPE). METHODS: Pleural effusion samples were collected from 78 patients with MPE, and from 48 patients with benign pleural effusion (BPE). Pleural effusion sRCAS1 concentrations were measured by enzyme-linked immunosorbent assay...
July 12, 2016: Clinical Respiratory Journal
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