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https://www.readbyqxmd.com/read/29771842/perceived-esthetic-outcomes-of-face-transplantation-a-survey-of-the-general-public
#1
Alessandra E Cabrera, Laura L Kimberly, Rami S Kantar, Elisa K Atamian, Amit K Manjunath, Lauren K Rangel, Michelle W McQuinn, J Rodrigo Diaz-Siso, Eduardo D Rodriguez
Facial transplantation (FT) has attracted the interest of individuals with facial disfigurement as a path to social reintegration. The perception among face transplant recipients and the reconstructive surgery community appears to be that superior functional and esthetic outcomes can be obtained with FT compared to autologous reconstruction (AR). Although lifelong immunosuppression adds well-known risks to FT, its benefits have proven difficult to quantify, especially because of its non-life-saving nature. Evidence that the general public perceives facial allograft recipients as less disfigured than AR patients may dramatically alter the currently accepted risk/benefit ratio of this novel procedure...
May 15, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29771838/face-transplantation-an-update-for-the-united-states-trauma-system
#2
Scott J Farber, Rami S Kantar, J Rodrigo Diaz-Siso, Eduardo D Rodriguez
Face transplantation has evolved over the last 12 years into a safe and feasible reconstructive solution, with good aesthetic and functional outcomes for patients with severe facial defects who are not amenable to reconstruction through conventional and autologous approaches. Among patients who underwent face transplantation to date, a significant proportion did so following trauma, mostly ballistic and thermal injuries. It is therefore important for trauma surgeons who deal with these injuries regularly to be familiar with the literature on face transplantation following traumatic injuries...
May 15, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29771837/face-of-the-future-lessons-learned-and-opportunities-in-composite-allotransplantation
#3
Rami S Kantar, J Rodrigo Diaz-Siso, Eduardo D Rodriguez
No abstract text is available yet for this article.
May 15, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29769666/an-unexpected-and-persistent-increase-in-global-emissions-of-ozone-depleting-cfc-11
#4
Stephen A Montzka, Geoff S Dutton, Pengfei Yu, Eric Ray, Robert W Portmann, John S Daniel, Lambert Kuijpers, Brad D Hall, Debra Mondeel, Carolina Siso, J David Nance, Matt Rigby, Alistair J Manning, Lei Hu, Fred Moore, Ben R Miller, James W Elkins
The Montreal Protocol was designed to protect the stratospheric ozone layer by enabling reductions in the abundance of ozone-depleting substances such as chlorofluorocarbons (CFCs) in the atmosphere1-3 . The reduction in the atmospheric concentration of trichlorofluoromethane (CFC-11) has made the second-largest contribution to the decline in the total atmospheric concentration of ozone-depleting chlorine since the 1990s 1 . However, CFC-11 still contributes one-quarter of all chlorine reaching the stratosphere, and a timely recovery of the stratospheric ozone layer depends on a sustained decline in CFC-11 concentrations 1 ...
May 2018: Nature
https://www.readbyqxmd.com/read/29719063/diabetes-is-not-associated-with-increased-rates-of-free-flap-failure-analysis-of-outcomes-in-6030-patients-from-the-acs-nsqip-database
#5
Rami S Kantar, William J Rifkin, Joshua A David, Michael J Cammarata, J Rodrigo Diaz-Siso, Jamie P Levine, Alyssa R Golas, Daniel J Ceradini
BACKGROUND: Diabetes affects a significant proportion of the population in the United States. Microsurgical procedures are common in this patient population, and despite many conflicting reports in the literature, there are no large studies evaluating the direct association between diabetes and outcomes, specifically failure, following free flap reconstruction. In this study, we sought to determine the impact of diabetes on postoperative outcomes following free flap reconstruction using a national multi-institutional database...
May 2, 2018: Microsurgery
https://www.readbyqxmd.com/read/29713761/hmgb-proteins-involved-in-tor-signaling-as-general-regulators-of-cell-growth-by-controlling-ribosome-biogenesis
#6
REVIEW
A Vizoso-Vázquez, A Barreiro-Alonso, M I González-Siso, E Rodríguez-Belmonte, M Lamas-Maceiras, M E Cerdán
The number of ribosomes and their activity need to be highly regulated because their function is crucial for the cell. Ribosome biogenesis is necessary for cell growth and proliferation in accordance with nutrient availability and other external and intracellular signals. High-mobility group B (HMGB) proteins are conserved from yeasts to human and are decisive in cellular fate. These proteins play critical functions, from the maintenance of chromatin structure, DNA repair, or transcriptional regulation, to facilitation of ribosome biogenesis...
April 30, 2018: Current Genetics
https://www.readbyqxmd.com/read/29697636/the-evolving-presence-of-women-in-academic-plastic-surgery-a-study-of-the-past-40-years
#7
Natalie M Plana, Kimberly S Khouri, Catherine C Motosko, Marleigh J Stern, Lavinia Anzai, Grace Poudrier, Jonathan P Massie, J Rodrigo Diaz-Siso, Roberto L Flores, Alexes Hazen
BACKGROUND: Among surgical subspecialties, plastic surgery holds the highest percentage of women, and, the female contingent of board-certified plastic surgeons and trainees has grown steadily. However, their academic impact has been underestimated. We present the academic footprint of female plastic surgeons over the past 40 years. METHODS: A list of female plastic surgeons currently active at, and retired from, Accreditation Council for Graduate Medical Education-accredited plastic surgery residency programs was compiled...
May 2018: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29697633/evaluating-the-july-phenomenon-in-plastic-surgery-a-national-surgical-quality-improvement-program-analysis
#8
Lauren K Rangel, Jose A Gonzalez, Rami S Kantar, Natalie M Plana, William J Rifkin, John T Stranix, J Rodrigo Diaz-Siso, Eduardo D Rodriguez
BACKGROUND: The perception that complications are more frequent earlier in the medical academic year, known as the "July phenomenon," has been studied in several specialties, with conflicting results. This phenomenon has yet to be studied in plastic surgery; therefore, this study sought to evaluate the presence of the July phenomenon within plastic surgery. METHODS: The American College of Surgeons National Surgical Quality Improvement Program database was accessed, and cases from 2005 to 2014 where "plastic surgery" was listed as the surgical specialty were identified...
May 2018: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29697617/outpatient-versus-inpatient-primary-cleft-lip-and-palate-surgery-analysis-of-early-complications
#9
Rami S Kantar, Michael J Cammarata, William J Rifkin, Natalie M Plana, J Rodrigo Diaz-Siso, Roberto L Flores
BACKGROUND: Fiscal constraints are driving shorter hospital lengths of stay. Outpatient primary cleft lip surgery has been shown to be safe, but outpatient primary cleft palate surgery remains controversial. This study evaluates outcomes following outpatient versus inpatient primary cleft lip and palate surgery. METHODS: The American College of Surgeons National Surgical Quality Improvement Program Pediatric database was used to identify patients undergoing primary cleft lip and palate surgery between 2012 and 2015...
May 2018: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29671724/facial-disfigurement-and-identity-a-review-of-the-literature-and-implications-for-facial-transplantation
#10
William J Rifkin, Rami S Kantar, Safi Ali-Khan, Natalie M Plana, J Rodrigo Diaz-Siso, Manos Tsakiris, Eduardo D Rodriguez
Facial disfigurement can significantly affect personal identity and access to social roles. Although conventional reconstruction can have positive effects with respect to identity, these procedures are often inadequate for more severe facial defects. In these cases, facial transplantation (FT) offers patients a viable reconstructive option. However, FT's effect on personal identity has been less well examined, and ethical questions remain regarding the psychosocial ramifications of the procedure. This article reviews the literature on the different roles of the face as well as psychological and social effects of facial disfigurement...
April 1, 2018: AMA Journal of Ethics
https://www.readbyqxmd.com/read/29649122/production-and-characterization-of-an-extracellular-acid-protease-from-thermophilic-brevibacillus-sp-oa30-isolated-from-an-algerian-hot-spring
#11
Mohamed Amine Gomri, Agustín Rico-Díaz, Juan-José Escuder-Rodríguez, Tedj El Moulouk Khaldi, María-Isabel González-Siso, Karima Kharroub
Proteases have numerous biotechnological applications and the bioprospection for newly-thermostable proteases from the great biodiversity of thermophilic microorganisms inhabiting hot environments, such as geothermal sources, aims to discover more effective enzymes for processes at higher temperatures. We report in this paper the production and the characterization of a purified acid protease from strain OA30, a moderate thermophilic bacterium isolated from an Algerian hot spring. Phenotypic and genotypic study of strain OA30 was followed by the production of the extracellular protease in a physiologically-optimized medium...
April 12, 2018: Microorganisms
https://www.readbyqxmd.com/read/29489486/achievements-and-challenges-in-facial-transplantation
#12
William J Rifkin, Joshua A David, Natalie M Plana, Rami S Kantar, J Rodrigo Diaz-Siso, Bruce E Gelb, Daniel J Ceradini, Eduardo D Rodriguez
: The first facial transplantation in 2005 ushered in a new era in reconstructive surgery, offering new possibilities for the repair of severe disfigurements previously limited by conventional techniques. Advances in allograft design, computerized preoperative planning, surgical technique, and postoperative revisions have helped push the boundaries in this new frontier of vascularized composite allotransplantation. Over the past 12 years, 40 of these procedures have been performed across the world, offering the field the opportunity to reflect on current outcomes...
February 27, 2018: Annals of Surgery
https://www.readbyqxmd.com/read/29485578/inconsistency-in-automated-reports-of-scientific-productivity-and-impact-in-academic-plastic-surgery
#13
Natalie M Plana, Jonathan P Massie, Jonathan M Bekisz, Elise M Fryml, Stuart Spore, J Rodrigo Diaz-Siso, Roberto L Flores
BACKGROUND: Currently, no consensus metric for measuring academic productivity within plastic surgery exists. The h-index is widely used, as it captures both the quantity and quality of an individual's contribution. However, discrepancies in online reporting make accurate h-index calculation challenging. This study highlights inconsistencies within plastic surgery by assessing differences in reporting of the h-index and other measures of academic productivity across online scientific databases...
March 2018: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29465050/antibacterial-effect-of-surface-pretreatment-techniques-against-streptococcus-mutans
#14
H S Sancakli, S H Siso, S O Yildiz, Y B Gökçe
Objective: The aim of this study was to evaluate the antibacterial surface pretreatment methods against Streptococcus mutans within the infected dentin surface using a tooth cavity model. Material and Methods: Seventy-two cavities were prepared on caries-free third molars (n = 8). After sterilization, teeth were inoculated with S. mutans for 48 h. One cavity of each tooth was used to evaluate the infection. Following inoculation, infected cavity surfaces were treated either with (1) Er:YAG Laser (1W; 5x5s, Smart 2940D Plus, Deka Laser), (2) Ozone (80s; HealOzone, Kavo), (3) ErYAG-Ozone combination, (4) Er:YAG-Ozone-CHX combination, (5) Chlorhexidine (CHX), (6) Clearfil Protect Bond (PB), (7) potassium-titanyl-phosphate (KTP) Laser (1W; 60 s, SMARTLITE D, Deka Laser), (8) KTP-Ozone combination, and (9) KTP-Ozone-CHX...
February 2018: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/29464175/quality-improvement-in-facial-transplantation-standard-approach-for-novel-procedures
#15
Rami S Kantar, William J Rifkin, J Rodrigo Diaz-Siso, G Leslie Bernstein, Eduardo D Rodriguez
No abstract text is available yet for this article.
January 2018: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/29449612/ixr1-regulates-ribosomal-gene-transcription-and-yeast-response-to-cisplatin
#16
Ángel Vizoso-Vázquez, Mónica Lamas-Maceiras, M Isabel González-Siso, M Esperanza Cerdán
Ixr1 is a Saccharomyces cerevisiae HMGB protein that regulates the hypoxic regulon and also controls the expression of other genes involved in the oxidative stress response or re-adaptation of catabolic and anabolic fluxes when oxygen is limiting. Ixr1 also binds with high affinity to cisplatin-DNA adducts and modulates DNA repair. The influence of Ixr1 on transcription in the absence or presence of cisplatin has been analyzed in this work. Ixr1 regulates other transcriptional factors that respond to nutrient availability or extracellular and intracellular stress stimuli, some controlled by the TOR pathway and PKA signaling...
February 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29433862/three-dimensionally-printed-bioactive-ceramic-scaffold-osseoconduction-across-critical-sized-mandibular-defects
#17
Christopher D Lopez, J Rodrigo Diaz-Siso, Lukasz Witek, Jonathan M Bekisz, Bruce N Cronstein, Andrea Torroni, Roberto L Flores, Eduardo D Rodriguez, Paulo G Coelho
BACKGROUND: Vascularized bone tissue transfer, commonly used to reconstruct large mandibular defects, is challenged by long operative times, extended hospital stay, donor-site morbidity, and resulting health care. 3D-printed osseoconductive tissue-engineered scaffolds may provide an alternative solution for reconstruction of significant mandibular defects. This pilot study presents a novel 3D-printed bioactive ceramic scaffold with osseoconductive properties to treat segmental mandibular defects in a rabbit model...
March 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29406778/the-first-year-of-global-cleft-surgery-education-through-digital-simulation-a-proof-of-concept
#18
Natalie M Plana, J Rodrigo Diaz-Siso, Derek M Culnan, Court B Cutting, Roberto L Flores
INTRODUCTION: Parallel to worldwide disparities in patient access to health care, the operative opportunities of surgical trainees are increasingly restricted across the globe. Efforts have been directed toward enhancing surgical education outside the operating room and reducing the wide variability in global trainee operative experience. However, high costs and other logistical concerns may limit the reproducibility and sustainability of nonoperative surgical education resources. METHODS: A partnership between the academic, nonprofit, and industry sectors resulted in the development of an online virtual surgical simulator for cleft repair...
April 2018: Cleft Palate-craniofacial Journal
https://www.readbyqxmd.com/read/29402204/glomeruloid-microvascular-proliferation-desmoplasia-and-high-proliferative-index-as-potential-indicators-of-high-grade-canine-choroid-plexus-tumors
#19
Luisa Vera Muscatello, Giancarlo Avallone, Fabienne Serra, Torsten Seuberlich, Maria Teresa Mandara, Silvia Sisó, Barbara Brunetti, Anna Oevermann
Choroid plexus tumors (CPT) are intraventricular neoplasms accounting for 10% of all primary central nervous system tumors in dogs. They are frequently classified according to the human WHO classification into choroid plexus papilloma (CPP, grade I), atypical CPP (aCPP, grade II), and choroid plexus carcinoma (CPC, grade III). Histological features observed in canine CPT such as increased vascular density (IVD) and glomeruloid microvascular proliferation (GMVP) are not part of the WHO classification. This multi-centric study aimed to investigate tumor-associated vascular hyperplasia in dogs by determining the prevalence of GMVP and IVD in 52 canine CPT and their association with tumor grade...
May 2018: Veterinary Pathology
https://www.readbyqxmd.com/read/29396278/internet-based-digital-simulation-for-cleft-surgery-education-a-5-year-assessment-of-demographics-usage-and-global-effect
#20
Rami S Kantar, Natalie M Plana, Court B Cutting, Jesus Rodrigo Diaz-Siso, Roberto L Flores
BACKGROUND: In October 2012, a freely available, internet-based cleft simulator was created in partnership between academic, nonprofit, and industry sectors. The purpose of this educational resource was to address global disparities in cleft surgery education. This report assesses demographics, usage, and global effect of our simulator, in its fifth year since inception. OBJECTIVE: Evaluate the global effect, usage, and demographics of an internet-based educational digital simulation cleft surgery software...
January 29, 2018: Journal of Surgical Education
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