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https://www.readbyqxmd.com/read/29343628/keeping-the-home-fires-burning-amp-activated-protein-kinase
#1
REVIEW
D Grahame Hardie
Living cells obtain energy either by oxidizing reduced compounds of organic or mineral origin or by absorbing light. Whichever energy source is used, some of the energy released is conserved by converting adenosine diphosphate (ADP) to adenosine triphosphate (ATP), which are analogous to the chemicals in a rechargeable battery. The energy released by the conversion of ATP back to ADP is used to drive most energy-requiring processes, including cell growth, cell division, communication and movement. It is clearly essential to life that the production and consumption of ATP are always maintained in balance, and the AMP-activated protein kinase (AMPK) is one of the key cellular regulatory systems that ensures this...
January 2018: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/29341952/a-pharmacological-review-leptadenia-reticulata-wight-arn-jivanti-the-real-life-giving-plant
#2
Jayesh M Dhalani, Pankaj B Nariya
The present review reveals a comprehensive description of various pharmacological studies carried out on Leptadenia reticulata, a source of several active compounds, i.e. Leptadenia reticulata plant belonging to family Asclepiadaceae, it is also known as 'Jivanti', used for the treatment of various ailments in human civilization as well as used in folk medicine as a remedy in various reported herbal formulations. The plant has been found to exhibit diverse pharmacological activities like antibacterial activity, anticancer activity, lactogenic eff ect, antioxidant activity, anti-implantation activity, anti-asthmatic activity, modulating eff ect, activity of silver nano particles, hepatoprotective activity, antifungal activity, antidiabetic activity and anti-infl ammatory activity...
December 20, 2017: Folia Medica
https://www.readbyqxmd.com/read/29322011/safety-evaluation-of-bon-sant%C3%A3-cleanser%C3%A2-polyherbal-in-male-wistar-rats-further-investigations-on-androgenic-and-toxicological-profile
#3
O Awodele, O E Kale, A O Odewabi, M Ekor, B A Salau, A O Adefule-Ositelu
Background: The global increase in acceptance and use of herbal remedies in recent times is still accompanied with poor knowledge of their potential adverse effects and the toxicological implications of their use are underestimated. Methods: Bon-santé Cleanser® (BSC), a polyherbal containing Anogeissus leiocarpus, Terminalia ivorensis, Massularia acuminate and Macuna pruriens, is an "energizer and hormone booster". We assessed the effect of BSC on reproductive function after administration for 60 days in male Wistar rats...
January 2018: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/29321985/traditional-persian-medicine-and-management-of-metabolic-dysfunction-in-polycystic-ovary-syndrome
#4
REVIEW
Ayda Hosseinkhani, Nasrin Asadi, Mehdi Pasalar, Mohammad M Zarshenas
Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women of reproductive age. Its cause is unknown and it remains the most enigmatic of reproductive disorders. The extant written documents of Traditional Persian Medicine (TPM) - with holistic approaches towards human health - contain remedies used for centuries. Before further experimental research on any of these treatments, it is appropriate to study current related scientific evidence on their possible pharmacological actions. This work aims to study PCOS and its treatments in TPM...
January 2018: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/29317303/herbal-medicine-uses-to-treat-people-with-epilepsy-a-survey-in-rural-communities-of-northern-peru
#5
Auditeau Emilie, Moyano Luz Maria, Bourdy Geneviève, Nizard Mandy, Jost Jérémy, Ratsimbazafy Voa, Preux Pierre-Marie, Boumediene Farid
ETHNOPHARMACOLOGICAL RELEVANCE: Epilepsy affects 150,000 people in Peru, with a prevalence of 16.6/1,000 and a treatment gap of 75%. Herbal medicine (HM) is widely used in this country. AIM OF THE STUDY: We aimed to assess the use of plants in a rural community in northern Peru as part of therapeutic strategies for people with epilepsy (PWE). MATERIALS AND METHODS: The study was a cross-sectional observational and descriptive study. The inclusion criteria for people with epilepsy were 2 years of age and over, having lived in the study area for at least 3 months and a confirmed diagnosis of epilepsy by a neurologist...
January 6, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29310671/antituberculosis-activity-phytochemical-identification-of-costus-speciosus-j-koenig-sm-cymbopogon-citratus-dc-ex-nees-stapf-and-tabernaemontana-coronaria-l-willd-and-their-effects-on-the-growth-kinetics-and-cellular-integrity-of-mycobacterium-tuberculosis-h37rv
#6
Suriyati Mohamad, Nur Najihah Ismail, Thaigarajan Parumasivam, Pazilah Ibrahim, Hasnah Osman, Habibah A Wahab
BACKGROUND: Costus speciosus, Cymbopogon citratus, and Tabernaemontana coronaria are herbal plants traditionally used as remedies for symptoms of tuberculosis (TB) including cough. The aims of the present study were to evaluate the in vitro anti-TB activity of different solvent partitions of these plants, to identify the phytochemical compounds, and to assess the effects of the most active partitions on the growth kinetics and cellular integrity of the tubercle organism. METHODS: The in vitro anti-TB activity of different solvent partitions of the plant materials was determined against M...
January 8, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29309845/non-conventional-antimicrobial-and-alternative-therapies-for-the-treatment-of-clostridium-difficile-infection
#7
REVIEW
Niloufar Roshan, Katherine A Hammer, Thomas V Riley
Clostridium difficile is an anaerobic, Gram-positive, spore-forming bacillus that causes disease ranging from self-limiting diarrhoea to severe pseudomembranous colitis. C. difficile infection (CDI) commonly affects hospitalised patients and is increasingly identified in patients in the community with no hospital contact. For the last 15 years the incidence of CDI worldwide has been rising, especially in the northern hemisphere. The yearly average number of hospitalizations as a result of this disease is estimated to be over a quarter of a million per year in the United States alone...
January 5, 2018: Anaerobe
https://www.readbyqxmd.com/read/29309470/the-evidence-for-herbal-and-botanical-remedies-part-2
#8
Michael Malone, Gary Tsai
In part one of this series, we discussed the studies that have been done on capsaicin, butterbur, green tea, and peppermint. In this installment, we outline the research on 5 additional remedies: turmeric/curcumin, which may be of benefit in ulcerative colitis; chamomile, which appears to offer relief to patients with anxiety; rosemary, which may help treat alopecia; as well as coffee and cocoa, which may have some cardiovascular benefits.
January 2018: Journal of Family Practice
https://www.readbyqxmd.com/read/29309469/the-evidence-for-herbal-and-botanical-remedies-part-1
#9
Michael Malone, Gary Tsai
There is evidence to support the use of capsaicin to relieve osteoarthritis and postherpetic neuralgia and support for green tea to serve as a lipid-lowering agent and help treat diabetes. Similarly, researchers have found that peppermint may be of value in the management of irritable bowel syndrome. We also review the literature on butterbur for migraine headaches, but serious safety issues exist.
January 2018: Journal of Family Practice
https://www.readbyqxmd.com/read/29302648/incidence-of-malaria-typhoid-co-infection-among-adult-population-in-unwana-community-afikpo-north-local-government-area-ebonyi-state-southeastern-nigeria
#10
O O Odikamnoro, I M Ikeh, F N Okoh, S C Ebiriekwe, I A Nnadozie, J O Nkwuda, G C Asobie
Background: Malaria and typhoid fever are two leading infections of poverty with serious health and socioeconomic impacts, and due to their geographical overlap, co-infections are very common. Their mimicking symptomatology often present with gross misdiagnosis and mistreatment. This study was carried out to determine the incidence of malaria and typhoid co-infections among adult population in Unwana Community, Afikpo-North Local Government Area of Ebonyi State. Materials and Methods: Three hundred and fifty (350) individuals were examined, their blood samples subjected to microscopic examination and widal agglutination tests, for identification of Plasmodium parasites and antibodies to Salmonella enterica serovar typhi respectively...
2018: African Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29299431/a-review-on-botanicals-with-wound-healing-activity-for-pemphigus-vulgaris-perspective-of-traditional-persian-medicine-and-conventional-medicine
#11
REVIEW
Fatemeh Atarzadeh, Amir Mohammad Jaladat, Babak Daneshfard, Ladan Dastgheib, Mohammad Kamalinejad, Gholamreza Amin
Objective: As a rare autoimmune disease, pemphigus vulgaris has a poor prognosis especially in lack of proper medical support. This blistering disease involves both the skin and mucus membranes. The challenge is improving the healing process of skin lesions of which, superimposed infections are among the main causes of the disease mortality. Accordingly, we aimed to assess the treatment options suggested by traditional Persian medicine (TPM) and compare them with current findings. Materials and Methods: We studied the main clinical and pharmaceutical textbooks of TPM (Kitāb al-hāwīfī al-tibb, the Canon of Medicine, Eksir-e-Aazam, Tuhfat al-mu'minīn, Makhzan al-adviyah (focusing on the skin chapter and respective herbal remedies for the inflamed skin and ulcers...
November 2017: Avicenna Journal of Phytomedicine
https://www.readbyqxmd.com/read/29298169/premenstrual-syndrome-evidence-based-evaluation-and-treatment
#12
Sarah M Appleton
Premenstrual dysphoric disorder (PMDD) is defined by both physical and psychiatric symptoms that impact a woman significantly during the luteal phase of her menstrual cycle. Diagnostic criteria for PMDD were firmly established in the Diagnostic and Statistical Manual of Mental Disorders V in 2013, but many patients fall short of the diagnosis while still appreciably affected by severe premenstrual symptoms. More recent and robust investigations have evaluated the efficacy of treatment ranging from serotonergic therapy to hormonal treatment as well as lifestyle and herbal remedies...
January 2, 2018: Clinical Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29278627/what-do-pregnant-women-know-about-harmful-effects-of-medication-and-herbal-remedies-use-during-pregnancy
#13
Tatjana Barišić, Ana Pecirep, Ruža Milićević, Anja Vasilj, Dejan Tirić
BACKGROUND: The objective of this study was assasment of women's knowledge and awareness on medication and herbal remedies use during pregnancy. SUBJECTS AND METHODS: Cross-sectional study was conducted in Department of Obstetrics and Gynaecology University Clinical Hospital Mostar. The study included 230 parturients (primipara) and 20 pharmacists who work in pharmacies of Mostar. Collected and analyzed data was based on a questionnaire of 25 questions. RESULTS: Out of total number of respondents (N =230), 159 of them (69...
December 2017: Psychiatria Danubina
https://www.readbyqxmd.com/read/29277366/role-of-withania-somnifera-ashwagandha-in-the-management-of-male-infertility
#14
REVIEW
Pallav Sengupta, Ashok Agarwal, Maria Pogrebetskaya, Shubhadeep Roychoudhury, Damayanthi Durairajanayagam, Ralf Henkel
To manage male infertility caused by hormonal imbalance, infections and other predicaments, multifarious treatment strategies are emerging worldwide. Contemporary treatments, such as assisted reproductive techniques, are costly with low success rates of only 10-30%; however, herbal remedies are gaining more attention as an alternative or supplementary therapeutic modality for male infertility. The beneficial effects induced by oral intake of the roots of a small evergreen shrub, Withania sominifera (Ashwagandha) on semen quality of infertile men have previously been studied...
December 7, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/29258493/antiplatelet-mechanism-of-an-herbal-mixture-prepared-from-the-extracts-of-phyllostachys-pubescens-leaves-and-prunus-mume-fruits
#15
Eunjung Son, Seung-Hyung Kim, Won-Kyung Yang, Dong-Seon Kim, Jimin Cha
BACKGROUND: Bamboo (Phyllostachys pubescens) leaves and Japanese apricot (Mume fructus) fruit are traditionally recognized to be safe herbs broadly used for food and medicinal purposes in Southeast Asia. Our group previously explored their antiplatelet effects. This study was designed to confirm inhibition effects of PM21 (a 2:1 mixture of bamboo leaf extract and Japanese apricot fruit extract) on platelet aggregation and evaluate its potency to use as an herbal remedy to prevent and/or treat the diseases caused by platelet aggregation and thrombus formation...
December 19, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29250442/conceptualising-the-factors-affecting-retention-in-care-of-patients-on-antiretroviral-treatment-in-kabwe-district-zambia-using-the-ecological-framework
#16
Ferdinand C Mukumbang, Joyce Chali Mwale, Brian van Wyk
Background: HIV remains a major public health challenge in Zambia. The roll-out of antiretroviral treatment (ART) has engendered new challenges in retention in care. Objective: To conceptualise the factors affecting retention in care of ART patients at three primary healthcare facilities using the ecological framework. Method: Qualitative data were collected through in-depth interviews with 45 ART patients and three focus group discussions with 20 healthcare providers from three primary healthcare facilities in Kabwe district, Zambia, and subjected to thematic content analysis...
2017: AIDS Research and Treatment
https://www.readbyqxmd.com/read/29238476/anti-hyperglycemic-and-antioxidant-potential-of-croton-bonplandianus-bail-fractions-in-correlation-with-polyphenol-content
#17
Uma Dharshini Karuppiah Vijayamuthuramalingam, Rajeswari Rajaram, Kalaivani Madhavaram Kuppusamy, Bhavana Jonnalagadda, Sumathy Arokiasamy
Objectives: Diabetes mellitus, a carbohydrate metabolic disorder, occurs due to absolute or relative deficiency of insulin. Current treatment strategies involve either preventing or delaying the intestinal absorption of glucose to lower the levels of postprandial hyperglycemia (PPHG). Herbal remedies have been since ancient times for treating diabetes mellitus. Therefore, identifying novel phytocompounds with α-amylase and α-glucosidase inhibitory activity that would reduce the glucose absorption as well as the rise in postprandial blood glucose level is vital...
December 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29234367/the-use-of-herbal-remedies-among-mothers-of-young-children-living-in-the-central-appalachian-region
#18
Monira Alwhaibi, Rashmi Goyat, Kimberly M Kelly
Introduction: Women often use herbal remedies as a complement or alternative to traditional medicine. Guided by the Comprehensive Model of Information Seeking, this study examined use of herbal remedies among mothers of young children living in the Central Appalachian Region. Methods: A cross-sectional study was conducted among mothers of young children (n = 178). The outcome measure of interest was the use of any herbal remedy in the past six months. Two scales were developed to measure information seeking channels and to measure beliefs about the safety/efficacy of herbal remedies...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29228790/an-evidence-based-study-on-medicinal-plants-for-hemorrhoids-in-medieval-persia
#19
Mohammad Hashem Hashempur, Fatemeh Khademi, Maryam Rahmanifard, Mohammad M Zarshenas
Hemorrhoids is one of the most common gastrointestinal diseases. There are several therapeutic options associated with some complications. Therefore, researchers look for traditional medicines as a potential resource for introduction of new natural drugs. The current study reports an evidence-based review of herbal remedies for hemorrhoids in traditional Persian medicine. A comprehensive survey about hemorrhoids on the most important manuscripts of traditional Persian medicine was done. Then, scientific data banks were searched for possible related properties of each herb in the conventional medicine...
October 2017: Journal of Evidence-based Complementary & Alternative Medicine
https://www.readbyqxmd.com/read/29217884/how-harmful-can-herbal-remedies-be-a-case-of-severe-acute-tubulointerstitial-nephritis
#20
P Beniwal, N Gaur, S K Singh, N Raveendran, V Malhotra
Acute interstitial nephritis (AIN) is a condition in which acute kidney injury (AKI) is characterized by the histological finding of interstitial inflammation. Hyponidd is an ayurvedic drug containing Momordica charantia, Gymnema sylvestre, Swertia chirata, etc., used for the treatment of Type 2 diabetes mellitus (DM) and polycystic ovarian disease as an insulin sensitizer. There are no case reports of AIN caused by this drug yet. We report a biopsy-proven case of AKI due to severe AIN associated with the use of hyponidd tablet in a 60-year-old male with DM and hypertension...
November 2017: Indian Journal of Nephrology
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