Natalia Machado, Francesca Raffin, Satvinder Kaur, Alexander Banks, Nicole Lynch, Oleksandra Fanari, Oscar Plascencia, Sydney Aten, Janayna Lima, Sathyajit Bandaru, Richard Palmiter, Elda Arrigoni, Clifford Saper
Many species use a temporary drop in body temperature and metabolic rate (torpor) as a strategy to survive food scarcity. A similar profound hypothermia is observed with activation of preoptic neurons that express the neuropeptides Pituitary Adenylate-Cyclase-Activating Polypeptide (PACAP) 1 , Brain Derived Neurotrophic Factor (BDNF) 2 , or Pyroglutamylated RFamide Peptide (QRFP) 3 , the vesicular glutamate transporter, Vglut2 4,5 or the leptin receptor6 (LepR), estrogen 1 receptor (Esr1) 7 or prostaglandin E receptor 3 (EP3R) in mice 8 ...
May 2, 2023: Research Square