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JOURNAL ARTICLE
Sille Schandorph Løkkegaard, Maria Louison Vang, Ask Elklit
BACKGROUND: Collaboration between clinical practice and research is often warranted. Extended periods of collaboration integrating research and practice is however rare. This article is about a series of joint research projects through the course of 8 years involving the Danish Center of Psychotraumatology and five regional centres dedicated to combating the sequelae of child abuse across Denmark. METHOD: We describe the development of a standardized assessment battery and how this work evolves, analyses of administrative data, what happens after the assessment, the impact of working with child abuse on employees, profiles of abuse that vary by gender, national conferences and training programs, and international collaboration...
March 15, 2024: Clinical Child Psychology and Psychiatry
#22
JOURNAL ARTICLE
Faizal Z Asumda, Nellie A Campbell, Mohamed A Hassan, Reza Fathi, Daniella F Vasquez Rico, Melanie Kiem, Ethan V Vang, Yo Han Kim, Xin Luo, Daniel R O'Brien, Sarah A Buhrow, Joel M Reid, Michael J Moore, Vered Katz Ben-Yair, Mark L Levitt, Jennifer L Leiting, Amro M Abdelrahman, Xinli Zhu, Fabrice Lucien, Mark J Truty, Lewis R Roberts
Upamostat is an orally available small-molecule serine protease inhibitor that is a highly potent inhibitor of trypsin 1, trypsin 2, trypsin 3 (PRSS1/2/3), and the urokinase-type plasminogen activator (uPA). These enzymes are expressed in many cancers, especially during tissue remodeling and subsequent tumor cell invasion. Opaganib (ABC294640), a novel, orally available small molecule is a selective inhibitor of the phosphorylation of sphingosine to sphingosine-1-phosphate (S-1-P) by sphingosine kinase 2 (SPHK2)...
March 5, 2024: Cancers
#23
JOURNAL ARTICLE
Dinh Thi Chi, Ho Le Thi, Le Van Vang, Tran Thanh Thy, Masanobu Yamamoto, Tetsu Ando
A lure composed of ( Z )-11-hexadecenal, ( Z )-11-hexadecenyl acetate, and ( Z )-11-hexadecen-1-ol at a ratio of 5 : 5 : 1 at a dose of 0.01 mg was optimal for the attraction of the Vietnamese strain of the diamondback moth (DBM). The combination of the sex pheromone with a plant volatile, allyl isothiocyanate, significantly increased the attraction of the pheromone trap. Females were also attracted, but they were only about 2% of all moths captured. In plots with 120-130 traps per ha, mass trapping with the combined lures reduced the DBM larval densities in cabbage fields as effectively as the spraying of insecticides 6 to 8 times...
February 20, 2024: Journal of Pesticide Science
#24
JOURNAL ARTICLE
Mette A Pedersen, Ole L Munk, André H Dias, Johanne H Steffensen, Anders L Møller, Anna Lyhne Johnsson, Kim Vang Hansen, Dirk Bender, Steen Jakobsen, Morten Busk, Lars C Gormsen, Trine Tramm, Signe Borgquist, Mikkel H Vendelbo
BACKGROUND: Correct classification of estrogen receptor (ER) status is essential for prognosis and treatment planning in patients with breast cancer (BC). Therefore, it is recommended to sample tumor tissue from an accessible metastasis. However, ER expression can show intra- and intertumoral heterogeneity. 16α-[18 F]fluoroestradiol ([18 F]FES) Positron Emission Tomography/Computed Tomography (PET/CT) allows noninvasive whole-body (WB) identification of ER distribution and is usually performed as a single static image 60 min after radiotracer injection...
March 4, 2024: EJNMMI Research
#25
REVIEW
Vasiliki Manaki, Vangelis Bontinis, Alkis Bontinis, Argirios Giannopoulos, M D PhD Ioannis Kontes, Angeliki Chorti, Kiriakos Ktenidis
BACKGROUND: We conducted a systematic review to assess the safety and efficacy of Aluminum potassium sulfate and tannic acid (ALTA) sclerotherapy for the treatment of hemorrhoidal disease. METHODS: Our study was conducted in accordance with the PRISMA statement (Preferred Reporting Items for Systematic Reviews and Meta-analyses) 2020. Primary endpoints included overall recurrence and type of recurrence while secondary endpoints included postoperative complications, reintervention, presence of rectal ulcer, rectal stricture, defecation abnormalities and perianal abscess...
March 1, 2024: Acta Chirurgica Belgica
#26
JOURNAL ARTICLE
Pavel Kudrin, Ankita Singh, David Meierhofer, Anna Kuśnierczyk, Ulf Andersson Vang Ørom
Stress granules are an integral part of the stress response that are formed from non-translating mRNAs aggregated with proteins. While much is known about stress granules, the factors that drive their mRNA localization are incompletely described. Modification of mRNA can alter the properties of the nucleobases and affect processes such as translation, splicing and localization of individual transcripts. Here, we show that the RNA modification N4-acetylcytidine (ac4C) on mRNA associates with transcripts enriched in stress granules and that stress granule localized transcripts with ac4C are specifically translationally regulated...
February 27, 2024: EMBO Reports
#27
JOURNAL ARTICLE
Sayan Maity, Vangelis Daskalakis, Thomas L C Jansen, Ulrich Kleinekathöfer
Diatoms are one of the most abundant photosynthetic organisms on earth and contribute largely to atmospheric oxygen production. They contain fucoxanthin and chlorophyll-a/c binding proteins (FCPs) as light-harvesting complexes with a remarkable adaptation to the fluctuating light on ocean surfaces. To understand the basis of the photosynthetic process in diatoms, the excitation energy funneling within FCPs must be probed. A state-of-the-art multiscale analysis within a quantum mechanics/molecular mechanics framework has been employed...
February 27, 2024: Journal of Physical Chemistry Letters
#28
JOURNAL ARTICLE
Jóngerð Midjord, Kári Rubek Nielsen, Amanda Gratton Vang, Marin Strøm, Søren Lophaven, Turid Hammer, Johan Burisch
BACKGROUND: The association between inflammatory bowel disease (IBD) and malignancy remains disputed despite many observational studies. The Faroese population exhibits the highest occurrence of IBD in the world. This study aimed to investigate the cancer risk in Faroese IBD patients in a nationwide IBD cohort. METHODS: This study included all IBD patients diagnosed in the Faroe Islands between 1960 and 2020. Clinical demographics and cancer diagnoses were retrieved from patient files and the Faroese cancer registry...
February 26, 2024: Scandinavian Journal of Gastroenterology
#29
JOURNAL ARTICLE
Bowy den Braber, Charlotte Hall, Martin Brandt, Florian Reiner, Maurice Mugabowindekwe, Laura Vang Rasmussen
Forests are attracting attention as a promising avenue to provide nutritious and "free" food without damaging the environment. Yet, we lack knowledge on the extent to which this holds in areas with sparse tree cover, such as in West Africa. This is largely due to the fact that existing methods are poorly designed to quantify tree cover in drylands. In this study, we estimate how various levels of tree cover across West Africa affect children's (aged 12-59 months) consumption of vitamin A-rich foods. We do so by combining detailed tree cover estimates based on PlanetScope imagery (3 m resolution) with Demographic Health Survey data from >15,000 households...
February 2024: PNAS Nexus
#30
REVIEW
Valborg Vang Poulsen, Amer Hadi, Mikkel Parsberg Werge, John Gásdal Karstensen, Srdan Novovic
Chronic pancreatitis (CP) is the end-stage of continuous inflammation and fibrosis in the pancreas evolving from acute- to recurrent acute-, early, and, finally, end-stage CP. Currently, prevention is the only way to reduce disease burden. In this setting, early detection is of great importance. Due to the anatomy and risks associated with direct sampling from pancreatic tissue, most of our information on the human pancreas arises from circulating biomarkers thought to be involved in pancreatic pathophysiology or injury...
February 18, 2024: Biomolecules
#31
JOURNAL ARTICLE
Johanna Lena Schön, Victoria Elisabeth Groß, Willem Berend Post, Alexandra Daum, Daniel Matúš, Johanna Pilz, Rene Schnorr, Susanne Horn, Miriam Bäumers, Stefanie Weidtkamp-Peters, Samantha Hughes, Torsten Schöneberg, Simone Prömel
The extracellular matrix (ECM) is a network of macromolecules that presents a vital scaffold for cells and enables multiple ways of cellular communication. Thus, it is essential for many physiological processes such as development, tissue morphogenesis, homeostasis, the shape and partially the size of the body and its organs. To ensure these, the composition of the ECM is tissue-specific and highly dynamic. ECM homeostasis is therefore tightly controlled by several mechanisms. Here, we show that FMI-1, the homolog of the Adhesion GPCR Flamingo/CELSR/ADGRC in the nematode Caenorhabditis elegans, modulates the composition of the ECM by controlling the production both of ECM molecules such as collagens and also of ECM modifying enzymes...
February 18, 2024: Matrix Biology: Journal of the International Society for Matrix Biology
#32
JOURNAL ARTICLE
Mariam-Eleni Oraiopoulou, Eleftheria Tzamali, Stylianos E Psycharakis, Georgios Tzedakis, Takis Makatounakis, Katina Manolitsi, Elias Drakos, Antonis F Vakis, Giannis Zacharakis, Joseph Papamatheakis, Vangelis Sakkalis
Adjuvant Temozolomide is considered the front-line Glioblastoma chemotherapeutic treatment; yet not all patients respond. Latest trends in clinical trials usually refer to Doxorubicin; yet it can lead to severe side-effects if administered in high doses. While Glioblastoma prognosis remains poor, little is known about the combination of the two chemotherapeutics. Patient-derived spheroids were generated and treated with a range of Temozolomide/Doxorubicin concentrations either as monotherapy or in combination...
February 14, 2024: Scientific Reports
#33
JOURNAL ARTICLE
Georgia Ragia, Eirini Biziota, Triantafyllia Koukaki, Kyriakos Amarantidis, Vangelis G Manolopoulos
Aim: MicroRNA 27a (miR-27a) regulates post-transcriptionally DPD activity. We have analyzed the association of MIR27A rs895819T>C variation, that modulates miR-27a expression, with FP-induced toxicity. Materials & methods: MIR27A rs895819T>C genotyping was conducted by TaqMan allelic discrimination assay in 313 FP-treated cancer patients. Results: In overdominance (TC vs TT + CC), TC genotype was associated with grade 3-4 toxicity (p = 0.002), any grade toxicity (p = 0...
February 14, 2024: Pharmacogenomics
#34
JOURNAL ARTICLE
Samir V Jenkins, Shruti Shah, Azemat Jamshidi-Parsian, Amir Mortazavi, Hailey Kristian, Gunnar Boysen, Kieng B Vang, Robert J Griffin, Narasimhan Rajaram, Ruud P M Dings
Resistance to radiation remains a significant clinical challenge in non-small cell lung carcinoma (NSCLC). It is therefore important to identify the underlying molecular and cellular features that drive acquired resistance. We generated genetically matched NSCLC cell lines to investigate characteristics of acquired resistance. Murine Lewis lung carcinoma (LLC) and human A549 cells acquired an approximate 1.5-2.5-fold increase in radiation resistance as compared to their parental match, which each had unique intrinsic radio-sensitivities...
February 1, 2024: Radiation Research
#35
REVIEW
Marcheta Hill, Christian Allen, Tyler K Williamson, Victor Martinez, Sydney Vangeli, Aroob Zaheer, Matthew T Kingery, Jake X Checketts
BACKGROUND: Bibliometric analysis is a useful tool for measuring the scholarly impact of a topic and its more and less heavily studied aspects. The purpose of this study is to use bibliometric analysis to comprehensively analyze the 50 articles with the highest citation indices in studies evaluating the treatment and outcomes of massive rotator cuff tears (mRCTs). METHODS: This cross-sectional study identified articles within the Scopus database published through December 2022...
February 2024: JSES Rev Rep Tech
#36
JOURNAL ARTICLE
Ghaith Almhanni, Indrani Sen, Sai Vang, Shaun Marczak, Kirk Herzog, Mark Twesme, Matthew Ryba, Gloria Krueger, Rachel Jack, Jason Beckermann, Thomas Carmody, Tiziano Tallarita
Endoscopic vein harvest remains underused in single-stage brachial-basilic arteriovenous fistula creation. We analyzed our results with the use of this technique in a cohort of predominantly obese (body mass index ≥30 kg/m2 ) patients. Demographics, intraoperative details, and outcomes for all consecutive patients who underwent single-stage endoscopic-assisted brachial-basilic arteriovenous fistula creation between 2020 and 2022 at a single institute were analyzed retrospectively. The primary outcomes were technical success, fistula maturation, and primary assisted and secondary patency rates...
April 2024: Journal of Vascular Surgery Cases and Innovative Techniques
#37
REVIEW
Ioannis Delniotis, Vangelis Bontinis, Kiriakos Ktenidis, Elena E Drakonaki, Nikiforos Galanis
PURPOSE: Utilizing ultrasound for the detection of distal forearm fractures in children presents a potential safe and radiation-free alternative compared to X-ray. METHODS: A systematic review was undertaken to compare the diagnostic accuracy of ultrasound in detecting distal forearm fractures in children with X-ray imaging within the period spanning January 2010 to August 2023. The electronic databases MEDLINE and Cochrane CENTRAL were utilized for data retrieval...
February 1, 2024: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
#38
JOURNAL ARTICLE
Yen-Wei Chien, Yeh Wang, Peng Huang, Barrett Craig Lawson, David L Kolin, M Herman Chui, Russell Vang, Tricia A Numan, T Rinda Soong, Brant G Wang, Saron Ann Smith, Chi-Long Chen, Rebecca Stone, Christopher Douville, Tian-Li Wang, Ie-Ming Shih
Serous tubal intraepithelial carcinoma (STIC) is the fallopian tube precursor lesion for most cases of pelvic high-grade serous carcinoma (HGSC). To date, the morphologic, molecular, and clinical heterogeneity of STIC and a less atypical putative precursor lesion, termed serous tubal intraepithelial lesion, has not been well characterized. Better understanding of precursor heterogeneity could impact the clinical management of women with incidental STICs (without concurrent carcinoma) identified in cases of prophylactic or opportunistic salpingectomy...
February 1, 2024: American Journal of Surgical Pathology
#39
JOURNAL ARTICLE
Robert Rauschkolb, Solveig Franziska Bucher, Isabell Hensen, Antje Ahrends, Eduardo Fernández-Pascual, Katja Heubach, Desiree Jakubka, Borja Jiménez-Alfaro, Andreas König, Tomáš Koubek, Alexandra Kehl, Anzar A Khuroo, Anja Lindstädter, Faizan Shafee, Tereza Mašková, Elena Platonova, Patrizia Panico, Carolin Plos, Richard Primack, Christoph Rosche, Manzoor A Shah, Maria Sporbert, Albert-Dieter Stevens, Flavio Tarquini, Katja Tielbörger, Sabrina Träger, Vibekke Vange, Patrick Weigelt, Aletta Bonn, Martin Freiberg, Barbara Knickmann, Birgit Nordt, Christian Wirth, Christine Römermann
Whereas temporal variability of plant phenology in response to climate change has already been well studied, the spatial variability of phenology is not well understood. Given that phenological shifts may affect biotic interactions, there is a need to investigate how the variability in environmental factors relates to the spatial variability in herbaceous species' phenology by at the same time considering their functional traits to predict their general and species-specific responses to future climate change...
January 29, 2024: International Journal of Biometeorology
#40
Morten E Allentoft, Martin Sikora, Alba Refoyo-Martínez, Evan K Irving-Pease, Anders Fischer, William Barrie, Andrés Ingason, Jesper Stenderup, Karl-Göran Sjögren, Alice Pearson, Bárbara Sousa da Mota, Bettina Schulz Paulsson, Alma Halgren, Ruairidh Macleod, Marie Louise Schjellerup Jørkov, Fabrice Demeter, Lasse Sørensen, Poul Otto Nielsen, Rasmus A Henriksen, Tharsika Vimala, Hugh McColl, Ashot Margaryan, Melissa Ilardo, Andrew Vaughn, Morten Fischer Mortensen, Anne Birgitte Nielsen, Mikkel Ulfeldt Hede, Niels Nørkjær Johannsen, Peter Rasmussen, Lasse Vinner, Gabriel Renaud, Aaron Stern, Theis Zetner Trolle Jensen, Gabriele Scorrano, Hannes Schroeder, Per Lysdahl, Abigail Daisy Ramsøe, Andrei Skorobogatov, Andrew Joseph Schork, Anders Rosengren, Anthony Ruter, Alan Outram, Aleksey A Timoshenko, Alexandra Buzhilova, Alfredo Coppa, Alisa Zubova, Ana Maria Silva, Anders J Hansen, Andrey Gromov, Andrey Logvin, Anne Birgitte Gotfredsen, Bjarne Henning Nielsen, Borja González-Rabanal, Carles Lalueza-Fox, Catriona J McKenzie, Charleen Gaunitz, Concepción Blasco, Corina Liesau, Cristina Martinez-Labarga, Dmitri V Pozdnyakov, David Cuenca-Solana, David O Lordkipanidze, Dmitri En'shin, Domingo C Salazar-García, T Douglas Price, Dušan Borić, Elena Kostyleva, Elizaveta V Veselovskaya, Emma R Usmanova, Enrico Cappellini, Erik Brinch Petersen, Esben Kannegaard, Francesca Radina, Fulya Eylem Yediay, Henri Duday, Igor Gutiérrez-Zugasti, Ilya Merts, Inna Potekhina, Irina Shevnina, Isin Altinkaya, Jean Guilaine, Jesper Hansen, Joan Emili Aura Tortosa, João Zilhão, Jorge Vega, Kristoffer Buck Pedersen, Krzysztof Tunia, Lei Zhao, Liudmila N Mylnikova, Lars Larsson, Laure Metz, Levon Yepiskoposyan, Lisbeth Pedersen, Lucia Sarti, Ludovic Orlando, Ludovic Slimak, Lutz Klassen, Malou Blank, Manuel González-Morales, Mara Silvestrini, Maria Vretemark, Marina S Nesterova, Marina Rykun, Mario Federico Rolfo, Marzena Szmyt, Marcin Przybyła, Mauro Calattini, Mikhail Sablin, Miluše Dobisíková, Morten Meldgaard, Morten Johansen, Natalia Berezina, Nick Card, Nikolai A Saveliev, Olga Poshekhonova, Olga Rickards, Olga V Lozovskaya, Olivér Gábor, Otto Christian Uldum, Paola Aurino, Pavel Kosintsev, Patrice Courtaud, Patricia Ríos, Peder Mortensen, Per Lotz, Per Persson, Pernille Bangsgaard, Peter de Barros Damgaard, Peter Vang Petersen, Pilar Prieto Martinez, Piotr Włodarczak, Roman V Smolyaninov, Rikke Maring, Roberto Menduiña, Ruben Badalyan, Rune Iversen, Ruslan Turin, Sergey Vasilyev, Sidsel Wåhlin, Svetlana Borutskaya, Svetlana Skochina, Søren Anker Sørensen, Søren H Andersen, Thomas Jørgensen, Yuri B Serikov, Vyacheslav I Molodin, Vaclav Smrcka, Victor Merts, Vivek Appadurai, Vyacheslav Moiseyev, Yvonne Magnusson, Kurt H Kjær, Niels Lynnerup, Daniel J Lawson, Peter H Sudmant, Simon Rasmussen, Thorfinn Sand Korneliussen, Richard Durbin, Rasmus Nielsen, Olivier Delaneau, Thomas Werge, Fernando Racimo, Kristian Kristiansen, Eske Willerslev
No abstract text is available yet for this article.
January 18, 2024: Nature
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