keyword
MENU ▼
Read by QxMD icon Read
search

vang

keyword
https://www.readbyqxmd.com/read/27912143/coupling-of-helix-e-f-motion-with-the-o-nitrito-and-2-nitrovinyl-coordination-in-myoglobin
#1
Androulla Ioannou, Alexandra Lambrou, Vangelis Daskalakis, Eftychia Pinakoulaki
Myoglobin (Mb) is known to react slowly with nitirite to form the green pigment by NO2(-) cordination to the heme Fe in the O-binding nitrito (O1NO2) mode and to the heme 2-vinyl position. Nitrite is a powerful oxidizing agent and a biological reservoir for NO that has been implicated in a variety of aerobic biological systems. Accordingly, it is important to elucidate the nature and variety of NO2(-) reaction mechanisms with Mb. We have performed principal component analysis (PCA, or essential dynamics) on Molecular Dynamics trajectories of all MbNO2 coordination states to resolve the most important motions in the protein at 298K...
November 25, 2016: Biophysical Chemistry
https://www.readbyqxmd.com/read/27911818/planar-cell-polarity-signaling-in-the-uterus-directs-appropriate-positioning-of-the-crypt-for-embryo-implantation
#2
Jia Yuan, Jeeyeon Cha, Wenbo Deng, Amanda Bartos, Xiaofei Sun, Hsin-Yi Henry Ho, Jean-Paul Borg, Terry P Yamaguchi, Yingzi Yang, Sudhansu K Dey
Blastocyst implantation is a complex process requiring coordination of a dynamic sequence of embryo-uterine interactions. Blood vessels enter the uterus from the mesometrium, demarcating the uterus into mesometrial (M) and antimesometrial (AM) domains. Implantation occurs along the uterine longitudinal axis within specialized implantation chambers (crypts) that originate within the evaginations directed from the primary lumen toward the AM domain. The morphological orientation of crypts in rodent uteri was recognized more than a century ago, but the mechanism remained unknown...
November 28, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27852065/mitochondria-targeted-antioxidant-skq1-reduces-age-related-alterations-in-the-ultrastructure-of-the-lacrimal-gland
#3
Lora E Bakeeva, Chupalav M Eldarov, Irina M Vangely, Nataliya G Kolosova, Valeriya B Vays
Dry eye syndrome is an eye disorder affecting many people at an old age. Because dry eye syndrome is accelerated by aging, a useful approach to the prevention of this syndrome may be an intervention into the aging process. Previously, we showed that the mitochondria-targeted antioxidant SkQ1 delays manifestations of aging and inhibits the development of age-related diseases including dry eye syndrome. Nevertheless, the link between SkQ1's effects and its suppression of age-related changes in the lacrimal gland remains unclear...
November 11, 2016: Oncotarget
https://www.readbyqxmd.com/read/27836204/a-nationwide-study-of-ovarian-serous-borderline-tumors-in-denmark-1978-2002-risk-of-recurrence-and-development-of-ovarian-serous-carcinoma
#4
Charlotte Gerd Hannibal, Russell Vang, Jette Junge, Kirsten Frederiksen, Robert J Kurman, Susanne K Kjaer
OBJECTIVE: Absolute risk and risk factors for recurrence and ovarian serous carcinoma following ovarian serous borderline tumors (SBTs) is not well-established. METHODS: We included all women with SBTs in Denmark, 1978-2002. Diagnoses were confirmed by centralized pathology review and classified as atypical proliferative serous tumor (APST) or noninvasive low-grade serous carcinoma (LGSC). Implants were classified as noninvasive or invasive. Medical records were collected and reviewed, and follow-up was obtained...
November 8, 2016: Gynecologic Oncology
https://www.readbyqxmd.com/read/27815981/nitrite-coordination-in-myoglobin
#5
Androulla Ioannou, Alexandra Lambrou, Vangelis Daskalakis, Eftychia Pinakoulaki
The coordination of nitrite in myoglobin (Mb) has been characterized by resonance Raman spectroscopy and the frequencies of the nitrite bound to the heme Fe as well to the 2-vinyl have been computed by density functional theory (DFT) calculations. The DFT Natural Bond Orbital (NBO) analysis and the extensive isotope-labeling in the resonance Raman experiments indicate that NO2(-) (O1NO2) is bound to the heme Fe via O1. Based on the vibrational characterization of the reversible transition between low and high spin FeONO/2-nitrovinyl species, we suggest that the key step that triggers the spin-change is the increase of the proximal FeNHis93 bond length...
October 14, 2016: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/27809589/are-immigrants-healthier-than-native-born-canadians-a-systematic-review-of-the-healthy-immigrant-effect-in-canada
#6
Zoua M Vang, Jennifer Sigouin, Astrid Flenon, Alain Gagnon
OBJECTIVES: Immigrants are typically healthier than the native-born population in the receiving country and also tend to be healthier than non-migrants in the countries of origin. This foreign-born health advantage has been referred to as the healthy immigrant effect (HIE). We examined evidence for the HIE in Canada. DESIGN: We employed a systematic search of the literature on immigration and health and identified 78 eligible studies. We used a narrative method to synthesize the HIE across different stages of the life-course and different health outcomes within each stage...
November 3, 2016: Ethnicity & Health
https://www.readbyqxmd.com/read/27804897/mental-states-and-activities-in-danish-narratives-children-with-autism-and-children-with-language-impairment
#7
Elisabeth Engberg-Pedersen, Rikke Vang Christensen
This study focuses on the relationship between content elements and mental-state language in narratives from twenty-seven children with autism (ASD), twelve children with language impairment (LI), and thirty typically developing children (TD). The groups did not differ on chronological age (10;6-14;0) and non-verbal cognitive skills, and the groups with ASD and TD did not differ on language measures. The children with ASD and LI had fewer content elements of the storyline than the TD children. Compared with the TD children, the children with ASD used fewer subordinate clauses about the characters' thoughts, and preferred talking about mental states as reported speech, especially in the form of direct speech...
November 2, 2016: Journal of Child Language
https://www.readbyqxmd.com/read/27804269/early-weight-loss-with-liraglutide-3-0-mg-predicts-1-year-weight-loss-and-is-associated-with-improvements-in-clinical-markers
#8
Ken Fujioka, Patrick M O'Neil, Melanie Davies, Frank Greenway, David C W Lau, Birgitte Claudius, Trine Vang Skjøth, Christine Bjørn Jensen, John P H Wilding
OBJECTIVE: To identify an early response criterion for predicting ≥5% weight loss with liraglutide 3.0 mg at week 56 and to compare efficacy outcomes in early responders (ERs) and early nonresponders (ENRs). METHODS: Using pooled data from the SCALE Obesity and Prediabetes and SCALE Diabetes trials, weight loss of ≥4% at 16 weeks best predicted ≥5% weight loss after 56 weeks. Weight loss and changes in cardiometabolic risk factors and health-related quality of life were evaluated in ERs (≥4% weight loss at week 16) and ENRs (<4% weight loss at week 16) completing 56 weeks' treatment...
November 2016: Obesity
https://www.readbyqxmd.com/read/27793323/extramammary-findings-in-diagnostic-breast-magnetic-resonance-imaging-among-patients-with-known-breast-cancer-incidence-and-cost-analysis
#9
Lisa M Hayes, Julia S Frebault, Jeffrey Landercasper, Andrew J Borgert, Choua A Vang, Jeanne M Johnson, Jared H Linebarger
BACKGROUND: Extramammary findings (EMFs) are common on breast magnetic resonance imaging (MRI). METHODS: A retrospective review of breast MRIs in breast cancer patients between January 2009 and December 2014 was performed to identify EMF occurrences, resultant evaluation, and added cost. RESULTS: EMFs were noted in 185 (59%) of 316 MRIs. Overall, 201 new EMFs were identified with 178 (89%) benign and 23 (11%) malignant. New malignant findings included 19 metastatic nodes (18 axillary, 1 internal mammary) and 4 primary malignancies (2 thyroid, 2 lung)...
September 30, 2016: American Journal of Surgery
https://www.readbyqxmd.com/read/27746070/use-of-tablet-devices-in-the-management-of-agitation-among-inpatients-with-dementia-an-open-label-study
#10
Ipsit V Vahia, Rujvi Kamat, Cheng Vang, Carolina Posada, Lisa Ross, Sarah Oreck, Alok Bhatt, Colin Depp, Dilip V Jeste, Daniel D Sewell
OBJECTIVE: To investigate the feasibility, safety, and utility of tablet devices as novel nonpharmacologic tools in managing older psychiatric inpatients with agitation and dementia. METHODS: Thirty-six patients at a geriatric psychiatry inpatient unit were provided with tablets when agitated and used various apps on the tablet related to communication, games, music, web browser, and photography during their stay. Study staff documented the frequency, duration, and app usage history and rated the extent to which agitation improved after tablet use...
August 4, 2016: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/27725345/bacterial-community-structures-in-freshwater-polar-environments-of-svalbard
#11
Spyridon Ntougias, Żaneta Polkowska, Sofia Nikolaki, Eva Dionyssopoulou, Panagiota Stathopoulou, Vangelis Doudoumis, Marek Ruman, Katarzyna Kozak, Jacek Namieśnik, George Tsiamis
Two thirds of Svalbard archipelago islands in the High Arctic are permanently covered with glacial ice and snow. Polar bacterial communities in the southern part of Svalbard were characterized using an amplicon sequencing approach. A total of 52,928 pyrosequencing reads were analyzed in order to reveal bacterial community structures in stream and lake surface water samples from the Fuglebekken and Revvatnet basins of southern Svalbard. Depending on the samples examined, bacterial communities at a higher taxonomic level mainly consisted either of Bacteroidetes, Betaproteobacteria, and Microgenomates (OP11) or Planctomycetes, Betaproteobacteria, and Bacteroidetes members, whereas a population of Microgenomates was prominent in 2 samples...
September 30, 2016: Microbes and Environments
https://www.readbyqxmd.com/read/27699241/adjuvanted-multi-epitope-vaccines-protect-hla-a-11-01-transgenic-mice-against-toxoplasma-gondii
#12
Kamal El Bissati, Aziz A Chentoufi, Paulette A Krishack, Ying Zhou, Stuart Woods, Jitender P Dubey, Lo Vang, Joseph Lykins, Kate E Broderick, Ernest Mui, Yasuhiro Suzuki, Qila Sa, Stephanie Bi, Nestor Cardona, Shiv K Verma, Laura Frazeck, Catherine A Reardon, John Sidney, Jeff Alexander, Alessandro Sette, Tom Vedvick, Chris Fox, Jeffrey A Guderian, Steven Reed, Craig W Roberts, Rima McLeod
We created and tested multi-epitope DNA or protein vaccines with TLR4 ligand emulsion adjuvant (gluco glucopyranosyl lipid adjuvant in a stable emulsion [GLA-SE]) for their ability to protect against Toxoplasma gondii in HLA transgenic mice. Our constructs each included 5 of our best down-selected CD8(+) T cell-eliciting epitopes, a universal CD4(+) helper T lymphocyte epitope (PADRE), and a secretory signal, all arranged for optimal MHC-I presentation. Their capacity to elicit immune and protective responses was studied using immunization of HLA-A*11:01 transgenic mice...
September 22, 2016: JCI Insight
https://www.readbyqxmd.com/read/27695711/effect-of-national-schistosomiasis-control-programme-on-taenia-solium-taeniosis-and-porcine-cysticercosis-in-rural-communities-of-tanzania
#13
Uffe Christian Braae, Pascal Magnussen, Wendy Harrison, Benedict Ndawi, Faustin Lekule, Maria Vang Johansen
Taenia solium is found throughout sub-Saharan Africa and co-endemic with schistosomiasis in many regions. Taenia solium leads to taeniosis and neurocysticercosis - the leading cause of preventable epilepsy globally. This study aimed to assess the effects of the National Schistosomiasis Control Programme on prevalence of taeniosis and porcine cysticercosis over a four year period in Tanzania. School-based mass drug administration (MDA) of praziquantel was carried out based on schistosomiasis endemicity. Four human and five porcine cross-sectional surveys were carried out from 2012 to 2015 in Mbozi and Mbeya district in Tanzania...
September 2016: Parasite Epidemiology and Control
https://www.readbyqxmd.com/read/27687697/widespread-dna-hypomethylation-and-differential-gene-expression-in-turner-syndrome
#14
Christian Trolle, Morten Muhlig Nielsen, Anne Skakkebæk, Philippe Lamy, Søren Vang, Jakob Hedegaard, Iver Nordentoft, Torben Falck Ørntoft, Jakob Skou Pedersen, Claus Højbjerg Gravholt
Adults with 45,X monosomy (Turner syndrome) reflect a surviving minority since more than 99% of fetuses with 45,X monosomy die in utero. In adulthood 45,X monosomy is associated with increased morbidity and mortality, although strikingly heterogeneous with some individuals left untouched while others suffer from cardiovascular disease, autoimmune disease and infertility. The present study investigates the leukocyte DNAmethylation profile by using the 450K-Illumina Infinium assay and the leukocyte RNA-expression profile in 45,X monosomy compared with karyotypically normal female and male controls...
September 30, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27659490/intergenerational-trauma-in-refugee-families-a-systematic-review
#15
Cindy C Sangalang, Cindy Vang
Although a robust literature describes the intergenerational effects of traumatic experiences in various populations, evidence specific to refugee families is scattered and contains wide variations in approaches for examining intergenerational trauma. Using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) criteria, the purpose of this systematic review was to describe the methodologies and findings of peer-reviewed literature regarding intergenerational trauma in refugee families...
September 22, 2016: Journal of Immigrant and Minority Health
https://www.readbyqxmd.com/read/27647272/assessment-of-dce-mri-parameters-for-brain-tumors-through-implementation-of-physiologically-based-pharmacokinetic-model-approaches-for-gd-dota
#16
Marios Spanakis, Eleftherios Kontopodis, Sophie Van Cauter, Vangelis Sakkalis, Kostas Marias
Dynamic-contrast enhanced magnetic resonance imaging (DCE-MRI) is used for detailed characterization of pathology of lesions sites, such as brain tumors, by quantitative analysis of tracer's data through the use of pharmacokinetic (PK) models. A key component for PK models in DCE-MRI is the estimation of the concentration-time profile of the tracer in a nearby vessel, referred as Arterial Input Function (AIF). The aim of this work was to assess through full body physiologically-based pharmacokinetic (PBPK) model approaches the PK profile of gadoteric acid (Gd-DOTA) and explore potential application for parameter estimation in DCE-MRI based on PBPK-derived AIFs...
October 2016: Journal of Pharmacokinetics and Pharmacodynamics
https://www.readbyqxmd.com/read/27633945/serum-and-wound-vancomycin-levels-after-intrawound-administration-in-primary-total-joint-arthroplasty
#17
Jeremiah D Johnson, Joseph M Nessler, Ryan D Horazdovsky, Sandy Vang, Avis J Thomas, Scott B Marston
BACKGROUND: Periprosthetic joint infection is the most common cause of readmissions after total joint arthroplasty (TJA). Intrawound vancomycin powder (VP) has reduced infection rates in spine surgery; however, there are no data regarding VP in primary TJA. METHODS: Thirty-four TJA patients received 2 g of VP intraoperatively to investigate VP's pharmacokinetics. Serum and wound concentrations were measured at multiple intervals over 24 hours after closure. RESULTS: All serum concentrations were subtherapeutic (<15μg/mL) and peaked 12 hours after closure (4...
October 26, 2015: Journal of Arthroplasty
https://www.readbyqxmd.com/read/27631634/ropivacaine-interleukin-6-and-tumor-necrosis-factor-alpha-plasma-levels-during-intermittent-epidural-and-continuous-wound-infusion-of-ropivacaine-for-analgesia-after-hysterectomy-or-myomectomy-an-observational-study
#18
Sophia L Markantonis, Aikaterini Melemeni, Marina Markidou, Stefania Irene Haikali, Vangelis Karalis, Argyro Fassoulaki
BACKGROUND/AIMS: The concentration-time profile of the long-acting local anesthetic ropivacaine after epidural (EP) administration at fixed time intervals or continuous subcutaneous (SC) infusion has not been fully evaluated. The objective of this work was to determine total plasma concentrations of ropivacaine and changes in cytokine interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-α) levels during EP and SC. METHODS: In this prospective randomized controlled trial, 18 patients undergoing abdominal hysterectomy or myomectomy were randomly selected to receive ropivacaine either every 6 h via an EP catheter or by continuous wound infusion along the skin incision, after a bolus dose, for 48 h...
2016: Pharmacology
https://www.readbyqxmd.com/read/27601994/differential-expression-and-function-of-pde8-and-pde4-in-effector-t-cells-implications-for-pde8-as-a-drug-target-in-inflammation
#19
Amanda G Vang, Chaitali Basole, Hongli Dong, Rebecca K Nguyen, William Housley, Linda Guernsey, Alexander J Adami, Roger S Thrall, Robert B Clark, Paul M Epstein, Stefan Brocke
Abolishing the inhibitory signal of intracellular cAMP is a prerequisite for effector T (Teff) cell function. The regulation of cAMP within leukocytes critically depends on its degradation by cyclic nucleotide phosphodiesterases (PDEs). We have previously shown that PDE8A, a PDE isoform with 40-100-fold greater affinity for cAMP than PDE4, is selectively expressed in Teff vs. regulatory T (Treg) cells and controls CD4(+) Teff cell adhesion and chemotaxis. Here, we determined PDE8A expression and function in CD4(+) Teff cell populations in vivo...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27593524/the-role-of-surface-chemistry-in-the-cytotoxicity-profile-of-graphene
#20
Waqar Majeed, Shawn Bourdo, Dayton M Petibone, Viney Saini, Kieng Bao Vang, Zeid A Nima, Karrer M Alghazali, Emilie Darrigues, Anindya Ghosh, Fumiya Watanabe, Daniel Casciano, Syed F Ali, Alexandru S Biris
Graphene and its derivative, because of their unique physical, electrical and chemical properties, are an important class of nanomaterials being proposed as foundational materials in nanomedicine as well as for a variety of industrial applications. A major limitation for graphene, when used in biomedical applications, is its poor solubility due to its rather hydrophobic nature. Therefore, chemical functionalities are commonly introduced to alter both its surface chemistry and biochemical activity. Here, we show that surface chemistry plays a major role in the toxicological profile of the graphene structures...
September 4, 2016: Journal of Applied Toxicology: JAT
keyword
keyword
70230
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"