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https://www.readbyqxmd.com/read/28811888/performance-test-and-verification-of-an-off-the-shelf-automated-avian-radar-tracking-system
#1
Roel May, Yngve Steinheim, Pål Kvaløy, Roald Vang, Frank Hanssen
Microwave radar is an important tool for observation of birds in flight and represents a tremendous increase in observation capability in terms of amount of surveillance space that can be covered at relatively low cost. Based on off-the-shelf radar hardware, automated radar tracking systems have been developed for monitoring avian movements. However, radar used as an observation instrument in biological research has its limitations that are important to be aware of when analyzing recorded radar data. This article describes a method for exploring the detection capabilities of a dedicated short-range avian radar system used inside the operational Smøla wind-power plant...
August 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28789929/commentary-on-comprehensive-transcriptional-analysis-of-early-stage-urothelial-carcinoma-hedegaard-j-lamy-p-nordentoft-i-algaba-f-h%C3%A3-yer-s-ulh%C3%A3-i-bp-vang-s-reinert-t-hermann-gg-mogensen-k-thomsen-mb-nielsen-mm-marquez-m-segersten-u-aine-m-h%C3%A3-glund-m-birkenkamp
#2
Byron H Lee
Non-muscle-invasive bladder cancer (NMIBC) is a heterogeneous disease with widely different outcomes. We performed a comprehensive transcriptional analysis of 460 early-stage urothelial carcinomas and showed that NMIBC can be subgrouped into 3 major classes with basal- and luminal-like characteristics and different clinical outcomes. Large differences in biological processes such as the cell cycle, epithelial-mesenchymal transition, and differentiation were observed. Analysis of transcript variants revealed frequent mutations in genes encoding proteins involved in chromatin organization and cytoskeletal functions...
August 5, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28771275/latency-transition-of-plasminogen-activator-inhibitor-type-1-is-evolutionarily-conserved
#3
Agnieszka Jendroszek, Malene S Sønnichsen, Andrés C Muñoz, Kato Leyman, Anni Christensen, Steen Vang Petersen, Tobias Wang, Christian Bendixen, Frank Panitz, Peter A Andreasen, Jan K Jensen
Plasminogen activator inhibitor type 1 (PAI-1) is a central regulator of fibrinolysis and tissue remodelling. PAI-1 belongs to the serpin superfamily and unlike other inhibitory serpins undergoes a spontaneous inactivation process under physiological conditions, termed latency transition. During latency transition the solvent exposed reactive centre loop is inserted into the central β-sheet A of the molecule, and is no longer accessible to reaction with the protease. More than three decades of research on mammalian PAI-1 has not been able to clarify the evolutionary advantage and physiological relevance of latency transition...
August 3, 2017: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/28767291/improving-asthma-control-through-asthma-action-plans-a-quality-improvement-project-at-a-midwest-community-clinic
#4
Laila S Akhter, Jeyn L Monkman, Gao Vang, Jeanne Pfeiffer
This urban community clinic had poor asthma outcomes compared to the state of Minnesota. The standard of care supports an annual Asthma Action Plan (AAP). However, the majority of patients at this clinic had not received one. This quality improvement project aimed to improve asthma control, measured by an asthma control test of at least 20, through AAP implementation supported by all team members. The clinic's interdisciplinary champion group implemented workflow changes via practice facilitation and Plan-Do-Study-Act cycles...
July 2017: Journal of Community Health Nursing
https://www.readbyqxmd.com/read/28767061/bifurcatriol-a-new-antiprotozoal-acyclic-diterpene-from-the-brown-alga-bifurcaria-bifurcata
#5
Vangelis Smyrniotopoulos, Christian Merten, Marcel Kaiser, Deniz Tasdemir
Linear diterpenes that are commonly found in brown algae are of high chemotaxonomic and ecological importance. This study reports bifurcatriol (1), a new linear diterpene featuring two stereogenic centers isolated from the Irish brown alga Bifurcariabifurcata. The gross structure of this new natural product was elucidated based on its spectroscopic data (IR, 1D and 2D-NMR, HRMS). Its absolute configuration was identified by experimental and computational vibrational circular dichroism (VCD) spectroscopy, combined with the calculation of (13)C-NMR chemical shielding constants...
August 2, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28746875/kmt5a-controls-hepatic-metabolic-pathways-by-facilitating-rna-pol-ii-release-from-promoter-proximal-regions
#6
Kostas C Nikolaou, Panagiotis Moulos, Vangelis Harokopos, George Chalepakis, Iannis Talianidis
H4K20 monomethylation maintains genome integrity by regulating proper mitotic condensation, DNA damage response, and replication licensing. Here, we show that, in non-dividing hepatic cells, H4K20Me1 is specifically enriched in active gene bodies and dynamically regulated by the antagonistic action of Kmt5a methylase and Kdm7b demethylase. In liver-specific Kmt5a-deficient mice, reduced levels of H4K20Me1 correlated with reduced RNA Pol II release from promoter-proximal regions. Genes regulating glucose and fatty acid metabolism were most sensitive to impairment of RNA Pol II release...
July 25, 2017: Cell Reports
https://www.readbyqxmd.com/read/28743955/early-synaptic-dysfunction-induced-by-%C3%AE-synuclein-in-a-rat-model-of-parkinson-s-disease
#7
Jenny-Ann Phan, Kathrine Stokholm, Justyna Zareba-Paslawska, Steen Jakobsen, Kim Vang, Albert Gjedde, Anne M Landau, Marina Romero-Ramos
Evidence suggests that synapses are affected first in Parkinson's disease (PD). Here, we tested the claim that pathological accumulation of α-synuclein, and subsequent synaptic disruption, occur in absence of dopaminergic neuron loss in PD. We determined early synaptic changes in rats that overexpress human α-synuclein by local injection of viral-vectors in midbrain. We aimed to achieve α-synuclein levels sufficient to induce terminal pathology without significant loss of nigral neurons. We tested synaptic disruption in vivo by analyzing motor defects and binding of a positron emission tomography (PET) radioligand to the vesicular monoamine transporter 2, (VMAT2), [(11)C]dihydrotetrabenazine (DTBZ)...
July 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28734846/matrix-gla-protein-t-138c-polymorphism-is-associated-with-carotid-intima-media-thickness-and-predicts-mortality-in-patients-with-diabetic-nephropathy
#8
Stefanos Roumeliotis, Athanasios Roumeliotis, Stylianos Panagoutsos, Efstathia Giannakopoulou, Nikolaos Papanas, Vangelis G Manolopoulos, Ploumis Passadakis, Anna Tavridou
AIMS: We sought to determine the predictive value of Matrix Gla Protein MGP T-138C polymorphism in relation to all-cause mortality, cardiovascular mortality and cardiovascular events in patients with diabetic nephropathy (DN). METHODS: MGP T-138C polymorphism was assessed in 40 diabetic patients without nephropathy and 118 patients at different stages of DN, including patients on hemodialysis. Measurement of carotid intima-media thickness (cIMT) was performed using real-time B-mode ultrasonography...
June 30, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28728886/effect-of-a-physical-activity-intervention-on-supar-levels-a-randomized-controlled-trial
#9
Christopher Rohde, Christoffer Polcwiartek, Eivind Andersen, Torkel Vang, Jimmi Nielsen
OBJECTIVES: Soluble urokinase-type plasminogen activator receptor (suPAR) is a novel inflammatory marker, associated with lifestyle diseases and mortality risk. No studies have investigated whether physical activity may reduce suPAR levels using a randomized controlled design. DESIGN AND METHODS: suPAR and C-reactive protein (CRP) levels were determined in blood samples from a previous randomized controlled trial with Pakistani immigrants in Norway, 2008. The study included physically inactive men that were randomized to an intervention group (supervised group exercises) or a control group and followed for 5 months...
July 4, 2017: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/28724167/in-vitro-controlled-release-of-two-new-tuberculocidal-adamantane-aminoethers-from-solid-pharmaceutical-formulations-ii
#10
Marilena Vlachou, Angeliki Siamidi, Dimitrios Spaneas, Dimitrios Lentzos, Polixeni Ladia, Konstantina Anastasiou, Ioannis Papanastasiou, Angeliki-Sofia Foscolos, Markos-Orestis Georgiadis, Vangelis Karalis, Tahsin Kellici, Thomas Mavromoustakos
The aim of the present investigation was to develop matrix tablet formulations for the in vitro controlled release of two new tuberculocidal adamantane aminoethers (compounds III and IV), congeneric to the adamantane derivative SQ109, which is in final clinical trials, and aminoethers (I) and (II), using carefully selected excipients, such as polyvinylpyrrolidone, sodium alginate and lactose. The tablets were prepared using the direct compression method and dissolution experiments were conducted using the US Pharmacopoeia type II apparatus (paddle method) in gastric and intestinal fluids...
July 19, 2017: Drug Research
https://www.readbyqxmd.com/read/28718337/julius-thomsen-a-life-in-chemistry-and-beyond
#11
Vangelis Antzoulatos
No abstract text is available yet for this article.
July 18, 2017: Ambix
https://www.readbyqxmd.com/read/28714908/%C3%AE-etal-uptake-by-sunflower-helianthus-annuus-irrigated-with-water-polluted-with-chromium-and-nickel
#12
Vasiliki Stoikou, Vangelis Andrianos, Sotiris Stasinos, Marios G Kostakis, Sofia Attiti, Nikolaos S Thomaidis, Ioannis Zabetakis
The water aquifers of the regions of Asopos River in Viotia and Messapia in Evia (Greece) have been contaminated with hexavalent chromium (Cr (VI)) and bivalent nickel (Ni (II)). Given that these areas are the two biggest tuber producing regions of Greece, in our previous work, the cross-contamination of the food chain with these two heavy metals was quantified. In the present study, the potential of sunflower (Helianthus annuus) cultivation in these regions is evaluated. The scope of our study was to investigate the uptake of chromium and nickel by sunflower, in a greenhouse experiment...
July 17, 2017: Foods (Basel, Switzerland)
https://www.readbyqxmd.com/read/28710434/modifying-dendritic-cell-activation-with-plasmonic-nano-vectors
#13
Kieng Bao Vang, Ingrid Safina, Emilie Darrigues, Dmitry Nedosekin, Zeid A Nima, Waqar Majeed, Fumiya Watanabe, Ganesh Kannarpady, Rajshekhar A Kore, Daniel Casciano, Vladimir P Zharov, Robert J Griffin, Ruud P M Dings, Alexandru S Biris
Dendritic cells (DCs) can acquire, process, and present antigens to T-cells to induce an immune response. For this reason, targeting cancer antigens to DCs in order to cause an immune response against cancer is an emerging area of nanomedicine that has the potential to redefine the way certain cancers are treated. The use of plasmonically active silver-coated gold nanorods (henceforth referred to as plasmonic nano vectors (PNVs)) as potential carriers for DC tumor vaccines has not been presented before. Effective carriers must be able to be phagocytized by DCs, present low toxicity, and induce the maturation of DCs-an early indication of an immune response...
July 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28676105/antipsychotic-associated-psoriatic-rash-a-case-report
#14
Camelia-Eugenia Bujor, Torkel Vang, Jimmi Nielsen, Ole Schjerning
BACKGROUND: Antipsychotics are a heterogeneous group of drugs. Although, antipsychotics have been used for years, unexpected side effects may still occur. With this case report we focus on a possible association between psoriasis and antipsychotics. Data on the patient's course of psychiatric disease, onset of psoriasis and its evolution were extracted from the patient's medical files. CASE PRESENTATION: We present a case of a 21-year-old female diagnosed with schizophrenia...
July 4, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28668592/physiologic-musculofascial-compliance-following-reinforcement-with-electrospun-polycaprolactone-ureidopyrimidinone-mesh-in-a-rat-model
#15
Lucie Hympanova, Marina Gabriela Monteiro Carvalho Mori da Cunha, Rita Rynkevic, Manuel Zündel, Monica Ramos Gallego, Jakob Vange, Geertje Callewaert, Iva Urbankova, Frank Van der Aa, Edoardo Mazza, Jan Deprest
PURPOSE: Electrospun meshes may be considered as substitutes to textile polypropylene implants. We compared the host response and biomechanical properties of the rat abdominal wall following reinforcement with either polycaprolactone (PCL) modified with ureidopyrimidinone-motifs (UPy) or polypropylene mesh. METHODS: First we measured the response to cyclic uniaxial load within the physiological range both dry (room temperature) and wet (body temperature). 36 rats underwent primary repair of a full-thickness abdominal wall defect with a polypropylene suture (native tissue repair), or reinforced with either UPy-PCL or ultra-light weight polypropylene mesh (n = 12/group)...
June 27, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28639505/rationale-and-design-of-the-multiethnic-pharmacogenomics-in-childhood-asthma-consortium
#16
Niloufar Farzan, Susanne J Vijverberg, Anand K Andiappan, Lambang Arianto, Vojko Berce, Natalia Blanca-López, Hans Bisgaard, Klaus Bønnelykke, Esteban G Burchard, Paloma Campo, Glorisa Canino, Bruce Carleton, Juan C Celedón, Fook Tim Chew, Wen Chin Chiang, Michelle M Cloutier, Denis Daley, Herman T Den Dekker, F Nicole Dijk, Liesbeth Duijts, Carlos Flores, Erick Forno, Daniel B Hawcutt, Natalia Hernandez-Pacheco, Johan C de Jongste, Michael Kabesch, Gerard H Koppelman, Vangelis G Manolopoulos, Erik Melén, Somnath Mukhopadhyay, Sara Nilsson, Colin N Palmer, Maria Pino-Yanes, Munir Pirmohamed, Uros Potočnki, Jan A Raaijmakers, Katja Repnik, Maximilian Schieck, Yang Yie Sio, Rosalind L Smyth, Csaba Szalai, Kelan G Tantisira, Steve Turner, Marc P van der Schee, Katia M Verhamme, Anke H Maitland-van der Zee
AIM: International collaboration is needed to enable large-scale pharmacogenomics studies in childhood asthma. Here, we describe the design of the Pharmacogenomics in Childhood Asthma (PiCA) consortium. MATERIALS & METHODS: Investigators of each study participating in PiCA provided data on the study characteristics by answering an online questionnaire. RESULTS: A total of 21 studies, including 14,227 children/young persons (58% male), from 12 different countries are currently enrolled in the PiCA consortium...
July 2017: Pharmacogenomics
https://www.readbyqxmd.com/read/28634004/minyoo-matata-the-vicious-worm-a-taenia-solium-computer-based-health-education-tool-in-swahili
#17
Chiara Trevisan, Eric M Fèvre, Maurice Owiny, Isaac Ngere, Maria Vang Johansen
Lack of knowledge is one of the main risk factors for the spread of the zoonotic parasite Taenia solium. The computer-based health-education tool 'The Vicious Worm' was developed to create awareness and provide evidence-based health education as a specific measure in control strategies. To increase the reach of the tool, a new version in Swahili was developed and can now be downloaded for free from http://theviciousworm.sites.ku.dk.
June 17, 2017: Trends in Parasitology
https://www.readbyqxmd.com/read/28628031/kinase-independent-functions-of-ripk1-regulate-hepatocyte-survival-and-liver-carcinogenesis
#18
Trieu-My Van, Apostolos Polykratis, Beate Katharina Straub, Vangelis Kondylis, Nikoletta Papadopoulou, Manolis Pasparakis
The mechanisms that regulate cell death and inflammation play an important role in liver disease and cancer. Receptor-interacting protein kinase 1 (RIPK1) induces apoptosis and necroptosis via kinase-dependent mechanisms and exhibits kinase-independent prosurvival and proinflammatory functions. Here, we have used genetic mouse models to study the role of RIPK1 in liver homeostasis, injury, and cancer. While ablating either RIPK1 or RelA in liver parenchymal cells (LPCs) did not cause spontaneous liver pathology, mice with combined deficiency of RIPK1 and RelA in LPCs showed increased hepatocyte apoptosis and developed spontaneous chronic liver disease and cancer that were independent of TNF receptor 1 (TNFR1) signaling...
June 30, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28600478/clinical-implications-of-monitoring-circulating-tumor-dna-in-patients-with-colorectal-cancer
#19
Lone V Schøler, Thomas Reinert, Mai-Britt W Ørntoft, Christine Gaasdal Kassentoft, Sigrid S Árnadóttir, Søren Vang, Iver Nordentoft, Michael Knudsen, Philippe Lamy, Ditte Andreasen, Frank V Mortensen, Anders Riegels Knudsen, Katrine Stribolt, Kim Sivesgaard, Peter Mouritzen, Hans Jørgen Nielsen, Søren Laurberg, Torben F Ørntoft, Claus L Andersen
We investigated if detection of circulating tumor DNA (ctDNA) after resection of colorectal cancer (CRC) identifies the patients with the highest risk of relapse, and furthermore, whether longitudinal ctDNA analysis allows early detection of relapse and informs about response to intervention.<br /><br />Experimental Design: In this longitudinal cohort study we used massively parallel sequencing to identify somatic mutations and used these as ctDNA markers to detect minimal residual disease and to monitor changes in tumor burden during a three year follow-up period...
June 9, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28593353/diabetic-ketoacidosis-and-diabetes-associated-with-antipsychotic-exposure-among-a-previously-diabetes-naive-population-with-schizophrenia-a-nationwide-nested-case-control-study
#20
Christoffer Polcwiartek, Kristian Kragholm, Christopher Rohde, Nasseh Hashemi, Torkel Vang, Jimmi Nielsen
AIMS/HYPOTHESIS: Diabetic ketoacidosis (DKA) is a potentially fatal metabolic emergency of both type 1 and type 2 diabetes. Although there is a reduced risk of type 1 diabetes in schizophrenia, the incidence of DKA is tenfold higher than that of the general population. Thus, we aimed to investigate associations between exposure to antipsychotic medication (within 3 months prior to event) and DKA, type 1 diabetes and type 2 diabetes. We also reported related, clinically relevant outcomes...
June 7, 2017: Diabetologia
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