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https://www.readbyqxmd.com/read/29758044/prickle-is-phosphorylated-by-nemo-and-targeted-for-degradation-to-maintain-prickle-spiny-legs-isoform-balance-during-planar-cell-polarity-establishment
#1
Giovanna M Collu, Andreas Jenny, Konstantin Gaengel, Ivana Mirkovic, Mei-Ling Chin, Ursula Weber, Michael J Smith, Marek Mlodzik
Planar cell polarity (PCP) instructs tissue patterning in a wide range of organisms from fruit flies to humans. PCP signaling coordinates cell behavior across tissues and is integrated by cells to couple cell fate identity with position in a developing tissue. In the fly eye, PCP signaling is required for the specification of R3 and R4 photoreceptors based upon their positioning relative to the dorso-ventral axis. The 'core' PCP pathway involves the asymmetric localization of two distinct membrane-bound complexes, one containing Frizzled (Fz, required in R3) and the other Van Gogh (Vang, required in R4)...
May 14, 2018: PLoS Genetics
https://www.readbyqxmd.com/read/29750703/an-epithelioid-smooth-muscle-neoplasm-mimicking-a-signet-ring-cell-carcinoma-in-the-ovary
#2
Deyin Xing, Alexander A Berrebi, Chengbao Liu, Abby Richmond, Russell Vang, Brigitte M Ronnett
A 53-yr-old woman who presented with elevated renal indices was discovered to have a 4.5 cm right renal mass and an incidental 9.7 cm left ovarian mass on imaging studies. She underwent a partial nephrectomy and bilateral salpingo-oophorectomy, revealing a chromophobe renal cell carcinoma and an unusual ovarian neoplasm with epithelioid cells displaying prominent signet ring cell-like morphology. Immunohistochemical analysis of the ovarian neoplasm demonstrated that the tumor cells were diffusely immunoreactive for smooth muscle markers and negative for all tested cytokeratins and epithelial membrane antigen...
May 10, 2018: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/29737589/ll-37-fragments-have-antimicrobial-activity-against-staphylococcus-epidermidis-biofilms-and-wound-healing-potential-in-hacat-cell-line
#3
Paola Saporito, Michelle Vang Mouritzen, Anders Løbner-Olesen, Håvard Jenssen
Staphylococcus epidermidis is a common nosocomial pathogen able to form biofilms in indwelling devices, resulting in chronic infections, which are refractory to antibiotics treatment. Staphylococcal biofilms are also associated with the delayed reepithelization and healing of chronic wounds. The human cathelicidin peptide LL-37 has been proven active against S. epidermidis biofilms in vitro and to promote wound healing. As previous studies have demonstrated that fragments of LL-37 could possess an equal antibacterial activity as the parent peptide, we tested whether shorter (12-mer) synthetic fragments of LL-37 maintained the antibiofilm and/or immune modulating activity, aiming at the identification of essential regions within the LL-37 parent sequence...
May 8, 2018: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://www.readbyqxmd.com/read/29728511/identification-of-cellular-sources-of-il-2-needed-for-regulatory-t-cell-development-and-homeostasis
#4
David L Owen, Shawn A Mahmud, Kieng B Vang, Ryan M Kelly, Bruce R Blazar, Kendall A Smith, Michael A Farrar
The cytokine IL-2 is critical for promoting the development, homeostasis, and function of regulatory T (Treg) cells. The cellular sources of IL-2 that promote these processes remain unclear. T cells, B cells, and dendritic cells (DCs) are known to make IL-2 in peripheral tissues. We found that T cells and DCs in the thymus also make IL-2. To identify cellular sources of IL-2 in Treg cell development and homeostasis, we used Il2FL/FL mice to selectively delete Il2 in T cells, B cells, and DCs. Because IL-15 can partially substitute for IL-2 in Treg cell development, we carried out the majority of these studies on an Il15-/- background...
May 4, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29724854/complete-genome-sequence-of-sinorhizobium-meliloti-bacteriophage-hmsp1-susan
#5
Brennon Fleagle, Aldina Imamovic, Silvia Toledo, Madison Couves, Autumn Jensen, Mandy Vang, Ashley Steevens, Nevin D Young, Michael J Sadowsky, Betsy M Martinez-Vaz
Sinorhiozbium bacteriophage HMSP1-Susan has a genome of 51,963 bp in size, with a GC content of 52.5%. It contains 97 putative coding sequences; 83% of these coding sequences (CDS) encode proteins classified as hypothetical or having unknown functions. HMSP1 has limited homology to previously reported viruses and likely represents a new phage that infects this nitrogen-fixing bacterium.
May 3, 2018: Genome Announcements
https://www.readbyqxmd.com/read/29694310/superior-vena-cava-syndrome-due-to-central-port-catheter-thrombosis-a-real-life-threatening-condition
#6
G D Lianos, N Hasemaki, E Tzima, G Vangelis, A Tselios, I Mpailis, E Lekkas
Superior vena cava syndrome (SVCS) represents undoubtedly a rare life-threatening condition. Herein, we present a rare case of a 69-year-old woman, with a history of hepatic flexure tumor and an indwelling central venous port, presenting with acute signs and symptoms of SVCS due to thrombosis of the catheter. The patient was treated with intravenous anticoagulation and fibrinolytic therapy and showed regression of symptoms. It is reported that central venous catheters are routinely used in clinical practice mainly in oncological cases for chemotherapy, parenteral nutrition or dialysis...
March 2018: Il Giornale di Chirurgia
https://www.readbyqxmd.com/read/29691407/long-ncrna-a-rod-activates-its-target-gene-dkk1-at-its-release-from-chromatin
#7
Evgenia Ntini, Annita Louloupi, Julia Liz, Jose M Muino, Annalisa Marsico, Ulf Andersson Vang Ørom
Long ncRNAs are often enriched in the nucleus and at chromatin, but whether their dissociation from chromatin is important for their role in transcription regulation is unclear. Here, we group long ncRNAs using epigenetic marks, expression and strength of chromosomal interactions; we find that long ncRNAs transcribed from loci engaged in strong long-range chromosomal interactions are less abundant at chromatin, suggesting the release from chromatin as a crucial functional aspect of long ncRNAs in transcription regulation of their target genes...
April 24, 2018: Nature Communications
https://www.readbyqxmd.com/read/29682527/corrigendum-to-simulating-radiotherapy-effect-in-high-grade-glioma-by-using-diffusive-modeling-and-brain-atlases
#8
Alexandros Roniotis, Kostas Marias, Vangelis Sakkalis, Georgios C Manikis, Michalis Zervakis
[This corrects the article DOI: 10.1155/2012/715812.].
2018: BioMed Research International
https://www.readbyqxmd.com/read/29671140/profiling-surgeon-performance-for-breast-cancer-lumpectomy-by-composite-measurement-of-reoperations-cosmetic-outcomes-and-patient-preferences
#9
Annie L Dunham, Luis D Ramirez, Choua A Vang, Jared H Linebarger, Jeffrey Landercasper
BACKGROUND: Patients want information to search for destination of care for breast-conserving surgery (BCS). To inform patients wanting a lumpectomy, we aimed to develop a pilot project that communicated composite quality measure (QM) results using a '4-star' rating system. Two patient-centered QMs were included in the model-reoperation rate (ROR) and cosmetic outcome (COSM). METHODS: A prospective database was reviewed for stage 0-3 patients undergoing initial lumpectomy by three surgeons from 2010 to 2015...
April 18, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29666305/a-switch-variant-model-integrates-the-functions-of-an-autoimmune-variant-of-the-phosphatase-ptpn22
#10
REVIEW
Torkel Vang, Jimmi Nielsen, Garth L Burn
The R620W polymorphism in protein tyrosine phosphatase nonreceptor type 22 (PTPN22) predisposes carriers to several autoimmune diseases. Two papers in Science Immunology and Science Signaling on this human disease-associated variant lead us to propose a new "switch-of-function" model.
April 17, 2018: Science Signaling
https://www.readbyqxmd.com/read/29658553/protein-protein-interactions-within-photosystem-ii-under-photoprotection-the-synergy-between-cp29-minor-antenna-subunit-s-psbs-and-zeaxanthin-at-all-atom-resolution
#11
Vangelis Daskalakis
The assembly and disassembly of protein complexes within cells are crucial life-sustaining processes. In photosystem II (PSII) of higher plants, there is a delicate yet obscure balance between light harvesting and photo-protection under fluctuating light conditions, that involves protein-protein complexes. Recent breakthroughs in molecular dynamics (MD) simulations are combined with new approaches herein to provide structural and energetic insight into such a complex between the CP29 minor antenna and the PSII subunit S (PsbS)...
April 16, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29629977/clinicopathologic-features-and-genetic-alterations-of-a-primary-osteosarcoma-of-the-uterine-corpus
#12
Gang Zheng, Abby Richmond, Chengbao Liu, Alexander Berrebi, Aparna Pallavajjala, Lisa Haley, Rebecca L Stone, Edward McCarthy, Russell Vang, Deyin Xing
Primary osteosarcoma (OS) of the uterus is distinctly rare. We report a case of primary uterine OS with pulmonary metastasis in a 74-yr-old woman. Histopathologic features of the uterine tumor were in keeping with a pure chondroblastic OS composed of neoplastic cells with osteoblastic/chondroblastic differentiation and neoplastic bone formation. Despite treatment with Doxorubicin and Olaratumab and later with palliative radiation therapy, the patient died 7 mo after hysterectomy due to multiple distant metastases...
April 6, 2018: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/29624127/depolarized-hepatocytes-express-the-stem-progenitor-cell-marker-neighbor-of-punc-e11-after-bile-duct-ligation-in-mice
#13
Andrea Bowe, Susanne Zweerink, Vera Mück, Vangelis Kondylis, Sigrid Schulte, Tobias Goeser, Dirk Nierhoff
There is a medical need of biomarkers for disease stratification in cholestatic liver diseases that come along with changes in hepatocyte polarity. Neighbor of Punc E11 (Nope) is an oncofetal marker that is lost after final differentiation and polarization of hepatocytes. We analyzed the expression pattern of Nope and connexin (Cx) 26 as markers of hepatocyte polarization during murine liver development as well as in adult liver with or without bile duct ligation (BDL) by quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR), western blotting (WB), and immunohistochemistry...
April 1, 2018: Journal of Histochemistry and Cytochemistry: Official Journal of the Histochemistry Society
https://www.readbyqxmd.com/read/29608396/metabolic-syndrome-and-vitamin-d-levels-in-patients-with-obstructive-sleep-apnea-syndrome
#14
Kostas Archontogeorgis, Evangelia Nena, Nikolaos Papanas, Manfredi Rizzo, Athanasios Voulgaris, Maria Xanthoudaki, Maria Kouratzi, Georgia Ragia, Vangelis Manolopoulos, Athanasios Zissimopoulos, Marios Froudarakis, Paschalis Steiropoulos
BACKGROUND: Numerous studies have indicated that obstructive sleep apnea syndrome (OSAS), may contribute to the development of metabolic syndrome (MetS) and diabetes. Moreover, OSAS has been associated with lowered vitamin D (Vit D) levels, but reports are inconclusive. Aim of the study was to compare Vit D levels according to the presence of MetS and its components in OSAS patients. METHODS: The presence of MetS was evaluated and serum 25-hydroxy vitamin D [25(OH)D] levels were measured in consecutive newly diagnosed, by polysomnography, subjects with OSAS...
April 2, 2018: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/29600161/optimizing-t-cell-expansion-in-a-hollow-fiber-bioreactor
#15
REVIEW
Brian Nankervis, Mark Jones, Boah Vang, R Brent Rice, Claire Coeshott, Jim Beltzer
Purpose of Review: Recent developments in regenerative medicine have precipitated the need to expand gene-modified human T cells to numbers that exceed the capacity of well-plate-based, and flask-based processes. This review discusses the changes in process development that are needed to meet the cell expansion requirements by utilizing hollow-fiber bioreactors . Maintenance of cell proliferation over long periods can become limited by unfilled demands for nutrients and oxygen and by the accumulation of waste products in the local environment...
2018: Current Stem Cell Reports
https://www.readbyqxmd.com/read/29587614/pharmacogenomics-in-ivf-a-new-era-in-the-concept-of-personalized-medicine
#16
Kallirhoe Kalinderi, Byron Asimakopoulos, Nikos Nikolettos, Vangelis G Manolopoulos
Pharmacogenomics is a promising approach in the field of individualized medicine in in vitro fertilization (IVF) treatment that aims to develop optimized pharmacotherapy depending on the genetic background of each infertile woman, thus to ensure maximum effectiveness of the medication used, with minimal side effects. The unique genetic information of each infertile woman, in combination with already known, as well as new predictors of ovarian response and the progress of pharmacoepigenomics, is anticipated to greatly benefit the process of controlled ovarian stimulation...
January 1, 2018: Reproductive Sciences
https://www.readbyqxmd.com/read/29580163/from-homer-and-hippocrates-to-modern-personalized-medicine-is-there-a-role-for-pharmacoepigenomics-in-the-treatment-of-alcohol-addiction
#17
Georgia Ragia, Vangelis G Manolopoulos
From the earliest times to the present, alcohol has evolved as part of life and culture. For most adults, moderate alcohol use is harmless, however, it lies at one end of a range that moves through alcohol abuse to alcohol addiction. Alcohol addiction is a serious and chronic psychiatric disorder that, on top of its heavy consequences on health, also brings significant social and economic losses to individuals and society at large. Pharmacotherapy of alcohol addiction exists, but its effectiveness varies significantly among individuals...
March 27, 2018: Pharmacogenomics
https://www.readbyqxmd.com/read/29560431/cd4-t-cells-react-to-local-increase-of-%C3%AE-synuclein-in-a-pathology-associated-variant-dependent-manner-and-modify-brain-microglia-in-absence-of-brain-pathology
#18
Mads N Olesen, Josefine R Christiansen, Steen Vang Petersen, Poul Henning Jensen, Wojciech Paslawski, Marina Romero-Ramos, Vanesa Sanchez-Guajardo
We have previously shown that immunological processes in the brain during α-synuclein-induced neurodegeneration vary depending on the presence or absence of cell death. This suggests that the immune system is able to react differently to the different stages of α-synuclein pathology. However, it was unclear whether these immune changes were governed by brain processes or by a direct immune response to α-synuclein modifications. We have herein locally increased the peripheral concentration of α-synuclein or its pathology-associated variants, nitrated or fibrillar, to characterize the modulation of the CD4 T cell pool by α-synuclein and brain microglia in the absence of any α-synuclein brain pathology...
January 2018: Heliyon
https://www.readbyqxmd.com/read/29559131/balancing-knowledge-and-basic-principles-in-veterinary-parasitology-competencies-for-future-danish-veterinary-graduates
#19
Stig Milan Thamsborg, Maria Vang Johansen, Peter Nejsum, Andrew R Williams, Helena Mejer
Veterinary parasitology has always been considered to be relevant and interesting by the Danish veterinary students. Students have to acquaint themselves with many new, small creatures with complicated and varied life cycles and with intricate Latin names that are difficult to pronounce, as only a few parasites have Danish names. In our veterinary curriculum, zoology has disappeared as a discipline, and parasitology has gradually moved from the third year to the beginning of the second year, which implies that, for example, pathology and pharmacology are "unknown fields"...
March 15, 2018: Veterinary Parasitology
https://www.readbyqxmd.com/read/29534702/assessment-of-the-societal-cost-of-taenia-solium-in-ang%C3%A3-nia-district-mozambique
#20
Chiara Trevisan, Brecht Devleesschauwer, Nicolas Praet, Alberto Pondja, Yunus Amade Assane, Pierre Dorny, Stig Milan Thamsborg, Pascal Magnussen, Maria Vang Johansen
BACKGROUND: The zoonotic parasite Taenia solium is endemic in Angónia district, Tete province, Mozambique, though the burden of the disease complex is unknown. METHODS: As part of two cross-sectional studies on human and porcine cysticercosis in the area, unique epidemiological and cost data were collected in Angónia district, Mozambique in 2007. These data provided the basis for the assessment of the societal cost of T. solium in the district, which estimates the impact of the disease on human and pig populations and includes both health and economic approaches in the analysis...
March 13, 2018: BMC Infectious Diseases
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