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Jacob Juel
Gastroesophageal reflux disease (GORD) is an often debilitating condition characterised by retrograde flow of content from stomach into the oesophagus, where the low pH of the stomach acid irritates the mucosa of the oesophagus. The most dominant symptoms in GORD are pyrosis, regurgitation, and dysphagia. Sublingual immunotherapy (SLIT) was first described in 1986. Following this description, the use has greatly increased in the treatment of allergic rhinitis, as an alternative to subcutaneously administered immunotherapy...
2017: Case Reports in Gastrointestinal Medicine
Belkisyolé Alarcón de Noya, Raiza Ruiz-Guevara, Oscar Noya, Julio Castro, John Ossenkopp, Zoraida Díaz-Bello, Cecilia Colmenares, José Antonio Suárez, Oscar Noya-Alarcón, Laura Naranjo, Humberto Gutiérrez, Giuseppa Quinci, Jaime Torres
BACKGROUND: Two old drugs are the only choice against Trypanosoma cruzi and little is known about their secondary effects in the acute stage of oral-transmitted Chagas disease (ChD). METHODS: A cross-sectional analytical surveillance study was conducted in a sizable cohort of patients seen during the largest acute foodborne ChD microepidemic registered so far. Individuals were treated with benznidazole (BNZ) or nifurtimox (NFX). 'Common Terminology Criteria for Adverse Events' was assessed to categorize side effects according to severity...
March 2017: Expert Review of Anti-infective Therapy
Yusuf Haydar Ertekin, Burkay Yakar, Hülya Ertekin, Ayşegül Uludağ, Murat Tekin
BACKGROUND: Drugs represent one of the etiologic causes of acute rhabdomyolysis (AR) with drug-induced rhabdomyolysis most commonly associated with HMG-CoA reductase inhibitors. AR etiology can also result from the use of diclofenac, a non-steroidal anti-inflammatory drug, and omeprazole, a proton pump inhibitor. Cases of AR triggered by pantoprazole have never before been reported, although it has been observed that its inclusion in multiple drug therapies can result in muscle events...
December 2015: Drug Safety—Case Reports
Rebekka Troller, Christopher Soll, Stefan Breitenstein
Glomus tumours are benign tumours typically arising from the glomus bodies and primarily found under the fingernails or toenails. These rare neoplasms account for <2% of all soft tissue tumours and are generally not found in the gastrointestinal tract. We report a case of a 40-year-old man presenting with recurrent epigastric pain and pyrosis. Endoscopy revealed a solitary tumour in the antrum of the stomach. Fine-needle aspiration biopsy was suspicious for a gastrointestinal stroma tumour. After CT indicated the resectability of the tumour, showing neither lymphatic nor distant metastases, a laparoscopic-assisted gastric wedge resection was performed...
June 24, 2016: BMJ Case Reports
Marye J Boers-Sonderen, Sasja F Mulder, Iris D Nagtegaal, Lauranne A A P Derikx, Geert J A Wanten, Peter F A Mulders, Winette T A van der Graaf, Frank Hoentjen, Carla M L van Herpen
BACKGROUND: Diarrhea is a frequently occurring adverse event during treatment with vascular endothelial growth factor receptor tyrosine kinase inhibitors (VEGFR TKIs) and is mostly accompanied by abdominal cramps, flatulence and pyrosis. These complaints impair quality of life and lead to dose reductions and treatment interruptions. It is hypothesized that the diarrhea might be due to ischemia in bowel mucosa or inflammation, but the exact underlying pathophysiological mechanism of the diarrhea is still unknown...
2016: Acta Oncologica
Robert C Tolboom, Werner A Draaisma, Ivo A M J Broeders
Surgery for refractory gastroesophageal reflux disease (GERD) and hiatal hernia leads to recurrence or persisting dysphagia in a minority of patients. Redo antireflux surgery in GERD and hiatal hernia is known for higher morbidity and mortality. This study aims to evaluate conventional versus robot-assisted laparoscopic redo antireflux surgery, with the objective to detect possible advantages for the robot-assisted approach. A single institute cohort of 75 patients who underwent either conventional laparoscopic or robot-assisted laparoscopic redo surgery for recurrent GERD or severe dysphagia between 2008 and 2013 were included in the study...
March 2016: Journal of Robotic Surgery
L Alecu, M Bărbulescu, B Ursuţ, V Braga, I Slavu
INTRODUCTION: Epiphrenic diverticula (ED) represent about 20% of oesophageal diverticula. They are considered to be pulsion diverticula, characterized by out pouchings of the oesophageal mucosa originating in the distal 10 cm of the oesophagus and are frequently associated with spastic oesophageal dysmotility. The most frequent clinical manifestations of ED are dysphagia, regurgitations and chest pain. Only symptomatic diverticula should be treated by surgery. The surgical procedure can be performed minimally invasively by robotic approach and consists of diverticulectomy,hiatus calibration and an antireflux procedure, usually adding an esophagomiotomy as well...
January 2015: Chirurgia
Elpidio Manuel Barajas-Fregoso, Teodoro Romero-Hernández, Patricio Rogelio Sánchez-Fernández, Clotilde Fuentes-Orozco, Alejandro González-Ojeda, Michel Dassaejv Macías-Amezcua
INTRODUCTION: Achalasia is a primary esophageal motor disorder. The most common symptoms are: dysphagia, chest pain, reflux and weight loss. The esophageal manometry is the standard for diagnosis. The aim of this paper is to determine the effectiveness of the surgical management in patients with achalasia in a tertiary care hospital. METHODS: A case series consisting of achalasia patients, treated surgically between January and December of 2011. Clinical charts were reviewed to obtain data and registries of the type of surgical procedure, morbidity and mortality...
January 2015: Revista Médica del Instituto Mexicano del Seguro Social
Geoffrey Gaillet, Olivier Favelle, Laurent Guilleminault, Anne de Muret, Etienne Lemarie, Thierry Lecomte, Sylvain Marchand-Adam, Patrice Diot
BACKGROUND: The link between organizing pneumonia (OP) and gastroesophageal reflux disease (GERD) is not well known. There is little evidence in the literature to establish a causal link between GERD and OP. OBJECTIVES: The aim of the study was to assess the hypothesis that OP is more severe when it is associated with GERD and that it leads to more frequent relapses. METHODS: In a retrospective study on 44 patients suffering from OP, we compared the clinical, radiological and histological characteristics of 2 groups, 1 composed of patients with GERD (n = 20) and the other of patients without GERD (n = 24)...
2015: Respiration; International Review of Thoracic Diseases
Usha K Coblijn, Sjoerd M Lagarde, Steve M M de Castro, Sjoerd D Kuiken, Bart A van Wagensveld
BACKGROUND: One of the long-term complications of laparoscopic Roux-and-Y gastric bypass (LRYGB) is the development of marginal ulcers (MU). The aim of the present study is to assess the incidence, risk factors, symptomatology and management of patients with symptomatic MU after LRYGB surgery. METHODS: A consecutive series of patients who underwent a LRYGB from 2006 until 2011 were evaluated in this study. Signs of abdominal pain, pyrosis, nausea or other symptoms of ulcer disease were analysed...
May 2015: Obesity Surgery
Carlos Alberto Soto-Medina, Erik Antonio Mier-Escurra, Francisco Treviño-Garza, Paola Ripa-Galván
BACKGROUND: Hamartoma is a slow-growing, rare mixed benign tumor. In general, it does not produce symptoms, so it is more commonly found as an incidentaloma during autopsies or laparotomies. Incidence of splenic hamartomas is low, representing 0.001% of the general population. CLINICAL CASE: We report the case of a 39 year-old male without relevant antecedents. The evolution of his condition began 2 months prior with pyrosis and occasional pain in the upper hemi-abdomen...
May 2014: Cirugia y Cirujanos
Ricardo Anuar Dib, Decio Chinzon, Luiz Henrique de Souza Fontes, Ana Cristina de Sá Teixeira, Tomás Navarro-Rodriguez
OBJECTIVES: To evaluate the prevalence of lesions and digestive complications secondary to the use of non-steroidal anti-inflammatory drugs (NSAIDs), the clinical profile seen for digestive complaints and the relation with the endoscopic findings. METHODS: Prospective, multicentric, open study, evaluating consecutively 1231 patients, divided as follows: group I - NSAID and group II - non-NSAID. All patients answered questionnaire to evaluate the onset, the type of clinical complaint, the use of medication and possible complications associated to digestive bleeding...
July 2014: Scandinavian Journal of Gastroenterology
Yann A Meunier, Michael K Hole
We present the case of a 32-year-old French man who presented with morning nausea, bloating, frequent flatulence, burping, occasional pyrosis, and alternating diarrhea and constipation two weeks after a trip to Morocco. The diagnosis was established by a parasitological stool exam that revealed cysts of Giardia lamblia. He was successfully treated with tinidazole.
May 16, 2011: Clinics and Practice
José A Herrera, Alberto Millán, Rómulo Ramos, Palmenia Fuentes, María González
UNLABELLED: Abstract. BACKGROUND: A controlled-release (CR) form of diclofenac-potassium has been developed, which delivers 100 mg over the course of 24 hours. This formulation is administered QD and provides steady plasmatic levels of the drug. OBJECTIVE: The aim of this study was to compare the effectiveness and tolerability of CR diclofenac-potassium versus the immediate-release (IR) formulation, when used for treatment of pain in patients with knee osteoarthritis...
March 2007: Current Therapeutic Research, Clinical and Experimental
Anteneh Belayneh, Negussie F Bussa
BACKGROUND: Traditional medicines remained as the most affordable and easily accessible source of treatment in the primary health care system among diverse communities in Ethiopia. The Oromo community living in the prehistoric Harla and Dengego valleys has long history of ethnomedicinal know-how and practice against human and livestock ailments. However, this rich ethnomedicinal knowledge had been remained unexplored hitherto. This study focus on the comprehensive ethnomedicinal investigation in an attempt to safeguard the deteriorating ethnomedicinal knowledge that can be used as a stepping-stone for phytochemical and pharmacological analysis...
2014: Journal of Ethnobiology and Ethnomedicine
Igor D Jovanović, Dragana R Jovanović, Sanja Pavlović, Branislav Milovanović, Milenko Uglješić, Nikola Milinić, Mirjana Cvetković, Marija Branković, Goran Nikolić
The report presents a case of a 46-year-old male patient, previously treated because of dysphagia, pyrosis, vertigo while standing up and impotency. Manometric and pH-metric analysis showed presence of gastroesophageal reflux disease (GERD) caused by transient relaxation of lower esophageal sphincter (TRLES). Heart-rate variability showed decreased sympathetic function. Electromyoneurography showed a neurological lesion in muscles of upper extremities. The patient received midodrine and clonazepam which resolved this condition...
February 2014: Medicinski Glasnik
Marcelo Rodrigues Bacci, Ethel Zimberg Chehter
BACKGROUNDS: Dyspepsia is a condition that affects 25% of the U.S. population, and, when associated with pyrosis, its prevalence reaches 40%. Patients with chronic renal insufficiency not only present higher circulating levels of gastrin and gastric dysmotilty, but also make use of a great amount of drugs for the treatment of their comorbidities. This situation increases the chances of developing gastrointestinal symptoms. The aim of the current study is to evaluate the dyspeptic disease profile in patients undergoing hemodialysis, comparing them with chronic renal disease patients in conservative treatment and non-renal injury patients...
October 20, 2013: International Archives of Medicine
Maşallah Baran, Funda Özgenç, Çiğdem Arikan, Murat Çakir, Çiğdem Ömür Ecevıt, Sema Aydoğdu, Raşit Vural Yağci
BACKGROUND/AIMS: Functional constipation and gastroesophageal reflux disease are two major and commonly encountered components of childhood functional gastrointestinal disorders. Epidemiological studies in the adult population support that there is a significant overlap between the different functional disorders of the digestive tract. Therefore, we aimed to investigate the frequency of gastroesophageal reflux disease in children with functional constipation and to compare clinical findings and 24-h esophageal pH monitoring with a group of patients with suspected gastroesophageal reflux disease...
2012: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
Giovanni Leuzzi, Alfredo Cesario, Stefano Margaritora, Anna Mariantonia Parisi, Venanzio Porziella, Elisa Meacci, Maria Letizia Vita, Maria Teresa Congedo, Marco Chiappetta, Pierluigi Granone
Skeletal muscle metastasis is a very rare event in patients with oesophageal cancer. We herein report and discuss a case of a 65 years old man with history of gastro-esophageal reflux disease referred to our department for pyrosis associated to persistent low back pain. Oesophageal endoscopy and transesophageal endo-sonography showed a tumour localized in the lower third of the esophagus, histologically proved to be adenocarcinoma. Clinical staging procedures detected a two centimetres vascularized nodular lesion placed into right para-vertebral muscles at the level of L4 as the only sign of potential distant disease (versus a differential diagnosis of primitive sarcoma)...
March 2013: Annali Italiani di Chirurgia
Fatih Yüksel, Mansur Doğan, Duran Karataş, Salim Yüce, Mehmet Şentürk, Ismail Külahli
OBJECTIVE: We aimed to evaluate a possible relation between gastroesophageal reflux disease and middle ear effusion in children. METHODS: Children who came to ear, nose, and throat (ENT) department with the symptoms of hearing loss or aural fullness and diagnosed as OME by examination and tympanometry were included into the study. Children were reviewed gastroesophageal reflux disease symptoms including the following: (a) airway symptoms: stridor, frequent cough, recurrent croup, wheezing, nasal congestion, obstructive apnea, hoarseness, and throat clearing; (b) feeding symptoms: frequent emesis, dysphagia, choking: gagging, sore throat, halitosis, food refusal, regurgitation, pyrosis, irritability, failure to thrive, and anemia...
March 2013: Journal of Craniofacial Surgery
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