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https://www.readbyqxmd.com/read/28716076/klf8-regulates-left-right-asymmetric-patterning-through-modulation-of-kupffer-s-vesicle-morphogenesis-and-spaw-expression
#1
Che-Yi Lin, Ming-Yuan Tsai, Yu-Hsiu Liu, Yu-Fen Lu, Yi-Chung Chen, Yun-Ren Lai, Hsin-Chi Liao, Huang-Wei Lien, Chung-Hsiang Yang, Chang-Jen Huang, Sheng-Ping L Hwang
BACKGROUND: Although vertebrates are bilaterally symmetric organisms, their internal organs are distributed asymmetrically along a left-right axis. Disruption of left-right axis asymmetric patterning often occurs in human genetic disorders. In zebrafish embryos, Kupffer's vesicle, like the mouse node, breaks symmetry by inducing asymmetric expression of the Nodal-related gene, spaw, in the left lateral plate mesoderm (LPM). Spaw then stimulates transcription of itself and downstream genes, including lft1, lft2, and pitx2, specifically in the left side of the diencephalon, heart and LPM...
July 17, 2017: Journal of Biomedical Science
https://www.readbyqxmd.com/read/28714100/why-is-it-so-hard-to-reach-agreement-on-terminology-the-case-of-developmental-language-disorder-dld
#2
Dorothy V M Bishop
A recent project entitled CATALISE used the Delphi method to reach a consensus on terminology for unexplained language problems in children. 'Developmental language disorder' (DLD) was the term agreed by a panel of 57 experts. Here I reflect on points of difficulty that arose when attempting to reach a consensus, using qualitative information from comments made by panel members to illustrate the kinds of argument used. One issue of debate was the use of labels, in particular the term 'disorder', which was seen as having both pros and cons...
July 17, 2017: International Journal of Language & Communication Disorders
https://www.readbyqxmd.com/read/28712353/cost-effectiveness-of-a-ptsd-intervention-tailored-for-individuals-with-severe-mental-illness
#3
Eric P Slade, Jennifer D Gottlieb, Weili Lu, Philip T Yanos, Stanley Rosenberg, Steven M Silverstein, Shula K Minsky, Kim T Mueser
OBJECTIVE: This study examined the cost-effectiveness of a cognitive-behavioral therapy (CBT) intervention for posttraumatic stress disorder (PTSD) that is tailored for adults with a co-occurring severe mental illness. METHODS: Data were from a randomized trial involving 183 adult clients of two outpatient clinics and three partial hospitalization programs. All had a severe mental illness diagnosis (major mood disorder, schizophrenia, or schizoaffective disorder) and severe PTSD...
July 17, 2017: Psychiatric Services: a Journal of the American Psychiatric Association
https://www.readbyqxmd.com/read/28707385/risk-factors-of-lower-urinary-tract-syndrome-among-ketamine-users
#4
I-Chun Chen, Ming-Huei Lee, Wei-Chih Chen, Tsung-Ching Hu, Hsiu-Ying Lin
OBJECTIVE: This study investigated the risk factors of ketamine associated-lower urinary tract symptoms (LUTS), such as duration of use, dosage of ketamine, co-occurring substance use of other psychoactive drugs, comorbidities, and depression. METHODS: This study was a cross-sectional survey. LUTS was assessed with the O'Leary symptom and problem index (OSPI) scores. We included the comorbidities of interstitial cystitis/painful bladder syndrome (IC/PBS) as comorbid factors...
July 13, 2017: Lower Urinary Tract Symptoms
https://www.readbyqxmd.com/read/28704146/legacy-interventions-with-patients-with-co-occurring-disorders-legacy-definitions-life-satisfaction-and-self-efficacy
#5
Felina C Franklin, Monit Cheung
BACKGROUND: Individuals with co-occurring disorders tend to avoid interaction with others. To instill hope, legacy intervention aims to highlight past experiences while managing life stressors for a positive outlook. Participants take part in legacy activities-crafting tangible projects and recording one's life events-in order to actualize a personal sense of legacy. OBJECTIVES: This pre-posttest research tested whether legacy intervention in a partial hospital program (PHP) on reframing past experiences through creative activities could increase life satisfaction and self-efficacy among adults with co-occurring substance misuse and mental health symptoms...
July 13, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/28702349/distinct-multivariate-brain-morphological-patterns-and-their-added-predictive-value-with-cognitive-and-polygenic-risk-scores-in-mental-disorders
#6
Nhat Trung Doan, Tobias Kaufmann, Francesco Bettella, Kjetil Nordbø Jørgensen, Christine Lycke Brandt, Torgeir Moberget, Dag Alnæs, Gwenaëlle Douaud, Eugene Duff, Srdjan Djurovic, Ingrid Melle, Torill Ueland, Ingrid Agartz, Ole A Andreassen, Lars T Westlye
The brain underpinnings of schizophrenia and bipolar disorders are multidimensional, reflecting complex pathological processes and causal pathways, requiring multivariate techniques to disentangle. Furthermore, little is known about the complementary clinical value of brain structural phenotypes when combined with data on cognitive performance and genetic risk. Using data-driven fusion of cortical thickness, surface area, and gray matter density maps (GMD), we found six biologically meaningful patterns showing strong group effects, including four statistically independent multimodal patterns reflecting co-occurring alterations in thickness and GMD in patients, over and above two other independent patterns of widespread thickness and area reduction...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28701904/medical-and-behavioral-approaches-to-engage-people-who-inject-drugs-into-care-for-hepatitis-c-virus-infection
#7
Stevan A Gonzalez, Daniel S Fierer, Andrew H Talal
Direct-acting antivirals for hepatitis C virus infection may revolutionize treatment among persons with substance use disorders. Despite persons with substance use disorders having the highest hepatitis C virus prevalence and incidence, the vast majority have not engaged into care for the infection. Previously, interferon-based treatments, with substantial side effects and the propensity to exacerbate mental health conditions, were major disincentives to pursuit of care for the infection. Direct-acting antivirals with viral eradication rates of >90%, significantly improved side effect profiles, and shorter treatment duration are dramatic improvements over prior treatment regimens that should promote widespread hepatitis C virus care among persons with substance use disorders...
June 2017: Addictive Disorders & Their Treatment
https://www.readbyqxmd.com/read/28697856/demographic-and-clinical-correlates-of-substance-use-disorders-in-first-episode-psychosis
#8
Mary F Brunette, Kim T Mueser, Steven Babbin, Piper Meyer-Kalos, Robert Rosenheck, Christoph U Correll, Corrine Cather, Delbert G Robinson, Nina R Schooler, David L Penn, Jean Addington, Sue E Estroff, Jennifer Gottlieb, Shirley M Glynn, Patricia Marcy, James Robinson, John M Kane
BACKGROUND: We assessed the prevalence and correlates of lifetime substance use disorders in people with first episode psychosis using the baseline data from the Recovery After an Initial Schizophrenia Episode (RAISE) Early Treatment Program study. METHODS: Research staff assessed 404 first episode patients at 34 community mental health centers across the United States with the Structured Clinical Interview for DSM-IV for diagnoses of psychotic and substance use disorders...
July 8, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28697606/dysphonia-in-adults-with-developmental-stuttering-a-descriptive-study
#9
Anél Botha, Elizbé Ras, Shabnam Abdoola, Jeannie Van der Linde
BACKGROUND: Persons with stuttering (PWS) often present with other co-occurring conditions. The World Health Organization's (WHO) International Classification of Functioning, Disability and Health (ICF) proposes that it is important to understand the full burden of a health condition. A few studies have explored voice problems among PWS, and the characteristics of voices of PWS are relatively unknown. The importance of conducting future research has been emphasised. OBJECTIVES: This study aimed to describe the vocal characteristics of PWS...
June 26, 2017: South African Journal of Communication Disorders. die Suid-Afrikaanse Tydskrif Vir Kommunikasieafwykings
https://www.readbyqxmd.com/read/28693877/a-qualitative-study-of-barriers-to-care-for-people-with-co-occurring-disorders
#10
Minna Sorsa, Tim Greacen, Juhani Lehto, Päivi Åstedt-Kurki
The present qualitative study used face-to-face and telephone interviews with service providers in the Tampere area in Finland to describe the provider viewpoint on barriers to care for people with co-occurring disorders. The core barrier concerns the definition and understanding of the problems: client and professional perspectives often differ, and both can be out of step with what the care system actually proposes. Professionals need to take into account contexts with potentially multiple barriers to care...
August 2017: Archives of Psychiatric Nursing
https://www.readbyqxmd.com/read/28693577/somatoform-dissociation-and-posttraumatic-stress-syndrome-two-sides-of-the-same-medal-a-comparison-of-symptom-profiles-trauma-history-and-altered-affect-regulation-between-patients-with-functional-neurological-symptoms-and-patients-with-ptsd
#11
Johanna Kienle, Brigitte Rockstroh, Martin Bohus, Johanna Fiess, Silke Huffziger, Astrid Steffen-Klatt
BACKGROUND: History of traumatic experience is common in dissociative disorder (DD), and similarity of symptoms and characteristics between DD and posttraumatic stress disorder (PTSD) encouraged to consider DD as trauma-related disorder. However, conceptualization of DD as a trauma-related syndrome would critically affect diagnosis and treatment strategies. The present study addressed overlap and disparity of DD and PTSD by directly comparing correspondence of symptoms, adverse/traumatic experience, and altered affect regulation between patients diagnosed with dissociative disorder (characterized by negative functional neurological symptoms) and patients diagnosed with PTSD...
July 11, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28692420/use-of-a-smartphone-recovery-tool-for-latinos-with-co-occurring-alcohol-and-other-drug-disorders-and-mental-disorders
#12
Jordana Muroff, Winslow Robinson, Deborah Chassler, Luz M López, Erika Gaitan, Lena Lundgren, Claudia Guauque, Susan Dargon-Hart, Emily Stewart, Diliana Dejesus, Kimberly Johnson, Klaren Pe-Romashko, David H Gustafson
OBJECTIVE: Addressing alcohol and other drug disorders (AOD) and other mental disorders (MD) among adult Hispanics/Latinos is of critical concern being one of the fastest growing ethnic groups with a disproportionate rate of disease, mental disorders, and poverty. Although improvement in outcomes is associated with sustained participation in ongoing treatment for co-occurring AOD/MD, continuing care is rare for these chronic conditions, especially for Latinos with more limited access to culturally and linguistically competent services...
July 10, 2017: Journal of Dual Diagnosis
https://www.readbyqxmd.com/read/28691500/factors-associated-with-sustained-community-employment-among-adults-with-autism-and-co-occurring-intellectual-disability
#13
Wai Chan, Leann E Smith, Jinkuk Hong, Jan S Greenberg, Julie Lounds Taylor, Marsha R Mailick
Sustaining community employment is a challenge for adults with autism spectrum disorders, especially for those who have co-occurring intellectual disability, but factors contributing to this employment outcome have not been fully evaluated. This study utilized longitudinal data to explore the impact of contextual influences, family factors, and individual characteristics on sustained employment over approximately 18 months ( N = 105). Very few adults with autism spectrum disorder and intellectual disability achieved sustained employment (14...
July 1, 2017: Autism: the International Journal of Research and Practice
https://www.readbyqxmd.com/read/28689852/development-of-an-integrated-cognitive-behavioral-therapy-for-anxiety-and-opioid-use-disorder-study-protocol-and-methods
#14
R Kathryn McHugh, Victoria R Votaw, David H Barlow, Garrett M Fitzmaurice, Shelly F Greenfield, Roger D Weiss
Opioid use disorder is a highly disabling psychiatric disorder, and is associated with both significant functional disruption and risk for negative health outcomes such as infectious disease and fatal overdose. Even among those who receive evidence-based pharmacotherapy for opioid use disorder, many drop out of treatment or relapse, highlighting the importance of novel treatment strategies for this population. Over 60% of those with opioid use disorder also meet diagnostic criteria for an anxiety disorder; however, efficacious treatments for this common co-occurrence have not be established...
July 8, 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/28689329/amygdala-volume-differences-in-autism-spectrum-disorder-are-related-to-anxiety
#15
John D Herrington, Brenna B Maddox, Connor M Kerns, Keiran Rump, Julie A Worley, Jennifer C Bush, Alana J McVey, Robert T Schultz, Judith S Miller
Recent studies suggest that longstanding findings of abnormal amygdala morphology in ASD may be related to symptoms of anxiety. To test this hypothesis, fifty-three children with ASD (mean age = 11.9) underwent structural MRI and were divided into subgroups to compare those with at least one anxiety disorder diagnosis (n = 29) to those without (n = 24) and to a typically developing control group (TDC; n = 37). Groups were matched on age and intellectual level. The ASD and anxiety group showed decreased right amygdala volume (controlled for total brain volume) relative to ASD without anxiety (p = ...
July 8, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28687708/germline-loss-of-function-mutations-in-ephb4-cause-a-second-form-of-capillary-malformation-arteriovenous-malformation-cm-avm2-deregulating-ras-mapk-signaling
#16
Mustapha Amyere, Nicole Revencu, Raphaël Helaers, Eleonore Pairet, Eulalia Baselga, Maria R Cordisco, Wendy K Chung, Josée Dubois, Jean-Philippe Lacour, Loreto Martorell, Juliette Mazereeuw-Hautier, Reed E Pyeritz, David J Amor, Annouk Bisdorff, Francine Blei, Hannah Bombei, Anne Dompmartin, David G Brooks, Juliette Dupont, Maria A González-Enseñat, Ilona J Frieden, Marion Gérard, Malin Kvarnung, Andrea Kwan Hanson-Kahn, Louanne Hudgins, Christine Léauté-Labrèze, Catherine McCuaig, Denise Metry, Philippe Parent, Carle Paul, Florence Petit, Alice Phan, Isabelle Quéré, Aicha Salhi, Anne M Turner, Pierre Vabres, Asuncion Vicente, Orli Wargon, Shoji Watanabe, Lisa Weibel, Ashley Wilson, Marcia Willing, John B Mulliken, Laurence M Boon, Miikka Vikkula
Background -Most AVMs are localized and occur sporadically; however they also can be multifocal in autosomal dominant disorders, such as Hereditary Hemorrhagic Telangiectasia (HHT) and Capillary Malformation-Arteriovenous Malformation (CM-AVM). Previously, we identified RASA1 mutations in 50% of patients with CM-AVM. Herein we studied non-RASA1 patients to further elucidate the pathogenicity of CMs and AVMs. Methods -We conducted a genome-wide linkage study on a CM-AVM family. Whole exome sequencing was also performed on 9 unrelated CM-AVM families...
July 7, 2017: Circulation
https://www.readbyqxmd.com/read/28686985/somatic-health-care-utilization-by-patients-treated-for-substance-use-disorders
#17
Gerdien H de Weert-van Oene, Fabian Termorshuizen, Victor J A Buwalda, Eibert R Heerdink
INTRODUCTION: Patients with substance use disorder (SUD) are frequently suffering from co-occurring somatic disorders, increasing the risk of mortality. Somatic health care utilization (sHCU) often remains unknown to the physician during SUD treatment. This paper analyses sHCU and associated costs among patients in SUD treatment compared to matched, non-substance dependent controls. METHODS: Health care utilization data on 4972 SUD patients were matched to 19,846 controls by gender, birth year and ethnic origin...
June 23, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28686107/critical-exploration-of-co-occurring-attention-deficit-hyperactivity-disorder-mood-disorder-and-substance-use-disorder
#18
Judith Regnart, Ilse Truter, Anneke Meyer
Co-occurring disorders (CODs) describe a Substance Use Disorder (SUD) accompanied by a comorbid psychiatric disorder. Attention-Deficit/Hyperactivity Disorder (ADHD) and mood disorders are common CODs with high prevalence rates in SUD populations. It is proposed that literature on a tri-condition presentation of ADHD, mood disorder and SUD is limited. Areas covered: A literature search was conducted using a keyword search on EBSCOhost. Initially 2 799 records were identified, however, only two articles included all three conditions occurring concurrently in individuals...
July 13, 2017: Expert Review of Pharmacoeconomics & Outcomes Research
https://www.readbyqxmd.com/read/28686068/differential-associations-between-excess-body-weight-and-psychiatric-disorders-in-men-and-women
#19
Mathilde M Husky, Carolyn M Mazure, Alexis Ruffault, Cécile Flahault, Viviane Kovess-Masfety
BACKGROUND: The current investigation is the first large-scale population-based study from France that documents the association between excess body weight and common psychiatric disorders, and examines the influence of gender on the association between excess body weight and these disorders. A recent plan has been implemented in France to treat the rising rate of those who are overweight or obese, and we seek to demonstrate whether integrated treatment of excess weight and psychiatric conditions appears as indicated...
July 7, 2017: Journal of Women's Health
https://www.readbyqxmd.com/read/28684647/hypersensitivity-to-antipyretics-pathogenesis-diagnosis-and-management
#20
REVIEW
Q U Lee
Antipyretics are commonly prescribed drugs and hypersensitivity occurs at rates of 0.01% to 0.3%. Hypersensitivity can be due to immune mechanisms that include type I to IV hypersensitivity. Type I hypersensitivity results from specific immunoglobulin E production following sensitisation on first exposure. Subsequent exposures elicit degranulation of mast cells, culminating an immediate reaction. Non-type I hypersensitivity is a delayed reaction that involves various effector cells, resulting in maculopapular rash, fixed drug eruptions, drug reaction with eosinophilia and systemic symptoms, and Stevens-Johnson syndrome/toxic epidermal necrolysis...
July 7, 2017: Hong Kong Medical Journal, Xianggang Yi Xue za Zhi
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