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https://www.readbyqxmd.com/read/29662526/factors-predicting-length-of-stay-in-an-adolescent-psychiatric-unit-south-bronx-ny-a-short-report
#1
Muhammad Zeshan, Ahmed Waqas, Sadiq Naveed, Hamzah Ghulam, Pankaj Manocha
Objective: Mental health disorders account for around 1.8 million inpatient community hospital stays in the U.S.A. Our study aims to highlight the factors impacting the length of stay at a community hospital in the U.S.A. Methods: We reviewed 300 randomly selected charts to examine the factors impacting the length of stay in an adolescent inpatient psychiatric unit in 2011 and 2015. All data were analyzed in SPSS v. 20 with multiple regression analysis. Results: Longer length of stay among adolescents was associated with multiple psychiatric diagnoses, co-occurring medical comorbidities, not living with biological parents, history of mental illness, legal problems, substance use in the family, seclusion, restraints during current admission, and schizophrenia...
April 2018: Journal of the Canadian Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/29656401/daily-patterns-of-marijuana-and-alcohol-co-use-among-individuals-with-alcohol-and-cannabis-use-disorders
#2
Jane Metrik, Rachel L Gunn, Kristina M Jackson, Alexander W Sokolovsky, Brian Borsari
BACKGROUND: The study aims were to examine daily associations between marijuana and alcohol use and the extent to which the association differs as a function of cannabis use disorder (CUD) and/or alcohol use disorder (AUD) diagnosis. METHODS: Timeline Followback interview data collected in a study of veterans (N=127) recruited from a Veterans Affairs hospital who reported at least one day of co-use of marijuana and alcohol in the past 180 days (22,860 observations)...
April 15, 2018: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29655386/a-comparative-network-analysis-of-eating-disorder-psychopathology-and-co-occurring-depression-and-anxiety-symptoms-before-and-after-treatment
#3
Kathryn E Smith, Tyler B Mason, Ross D Crosby, Li Cao, Rachel C Leonard, Chad T Wetterneck, Brad E R Smith, Nicholas R Farrell, Bradley C Riemann, Stephen A Wonderlich, Markus Moessner
BACKGROUND: Network analysis is an emerging approach in the study of psychopathology, yet few applications have been seen in eating disorders (EDs). Furthermore, little research exists regarding changes in network strength after interventions. Therefore the present study examined the network structures of ED and co-occurring depression and anxiety symptoms before and after treatment for EDs. METHOD: Participants from residential or partial hospital ED treatment programs (N = 446) completed assessments upon admission and discharge...
April 15, 2018: Psychological Medicine
https://www.readbyqxmd.com/read/29651923/identification-of-domestic-violence-service-needs-among-child-welfare-involved-parents-with-substance-use-disorders-a-gender-stratified-analysis
#4
Bryan G Victor, Stella M Resko, Joseph P Ryan, Brian E Perron
The current study examined the prevalence and associations of a need for domestic violence services among child welfare-involved mothers and fathers with substance use disorders. Data were drawn from 2,231 child welfare-involved parents in Illinois with an identified substance use disorder. Approximately 42% of mothers and 33% of fathers with a substance use disorder had a concurrent need for domestic violence services. The sample was stratified by gender and logistic regression models were fit to determine the adjusted odds of an identified need for domestic violence services...
April 1, 2018: Journal of Interpersonal Violence
https://www.readbyqxmd.com/read/29649778/in-silico-design-of-small-peptides-antagonist-against-leptin-receptor-for-the-treatment-of-obesity-and-its-associated-immune-mediated-diseases
#5
Manne Munikumar, Vagolu Siva Krishna, Varikasuvu Seshadri Reddy, Bolla Rajeswari, Dharmarajan Sriram, Mendu Vishnuvardhana Rao
Excess adiposity in obese inhibits negatively impacts immune function and host defence. Obesity is characterized by a state of low-grade, chronic inflammation in addition to disturbed levels of circulating nutrients and metabolic hormones. The impact of metabolic abnormalities on obesity-related co-morbidities has undergone intense scrutiny over the past decades. Thus, treatment of obesity and its associated immune-mediated diseases is challenging due to impaired function of leptin system. These disorders are managed through antibiotics and by cytokines replacement...
April 4, 2018: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/29649018/frequency-of-map2k1-tp53-and-u2af1-mutations-in-braf-mutated-langerhans-cell-histiocytosis-further-characterizing-the-genomic-landscape-of-lch
#6
Lisa M McGinnis, Grant Nybakken, Lisa Ma, Daniel A Arber
Langerhans cell histiocytosis is a proliferative disorder of neoplastic Langerhans cells with activating mutations in the Erk signaling pathway. TP53 and U2AF1 mutations have been implicated in other myelomonocytic malignancies and we hypothesized that mutations in these genes may cosegregate in LCH patients according to BRAF mutation status. Towards this end, we collected cases with a pathologic diagnosis of Langerhans cell histiocytosis from Stanford University Hospital. We analyzed the status of known pathogenic alleles in BRAF, ARAF, TP53, U2AF1, and MAP2K1 on formalin-fixed, paraffin-embedded tissue by direct sequencing...
April 11, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29642485/differential-diagnosis-of-autism-spectrum-disorder-and-post-traumatic-stress-disorder-two-clinical-cases
#7
Katherine Kuhl-Meltzoff Stavropoulos, Yasamine Bolourian, Jan Blacher
Autism spectrum disorder (ASD) is estimated to affect one in 68 children. Given the increase in both prevalence and awareness of ASD, it is critical to provide accurate and timely diagnosis. However, ASD often co-occurs with other disorders, making diagnosis difficult. The objective of the current case study was to provide two examples of differential diagnosis in ASD and post-traumatic stress disorder (PTSD) observed in an autism clinic. In both cases, the goal was to decide whether each child should be given a diagnosis of ASD, PTSD, or both...
April 8, 2018: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/29625429/a-latent-variable-approach-to-differentiating-neural-mechanisms-of-irritability-and-anxiety-in-youth
#8
Katharina Kircanski, Lauren K White, Wan-Ling Tseng, Jillian Lee Wiggins, Heather R Frank, Stefanie Sequeira, Susan Zhang, Rany Abend, Kenneth E Towbin, Argyris Stringaris, Daniel S Pine, Ellen Leibenluft, Melissa A Brotman
Importance: Comorbidity is ubiquitous in psychiatry, but it is unclear how to differentiate neural mechanisms of co-occurring symptoms. Pediatric irritability and anxiety symptoms are prevalent and frequently co-occur. Threat orienting is pertinent to both phenotypes and is an ideal context in which to examine their unique and common neural mechanisms. Objectives: To decompose the unique and shared variances of pediatric irritability and anxiety symptoms and to determine neural correlates of these differentiated phenotypes during threat orienting...
April 6, 2018: JAMA Psychiatry
https://www.readbyqxmd.com/read/29618356/in-vitro-maturation-of-oocytes-from-excised-ovarian-tissue-in-a-patient-with-autoimmune-ovarian-insufficiency-possibly-associated-with-epstein-barr-virus-infection
#9
Irma Virant-Klun, Andrej Vogler
BACKGROUND: Some reports show that it is possible to isolate immature oocytes from human ovarian tissue retrieved by a cortex biopsy or ovariectomy of non-stimulated ovaries and mature them in vitro. The mature oocytes can be vitrified and stored for in vitro fertilization, which, along with ovarian tissue cryopreservation, is mostly practiced in young cancer patients to preserve their fertility. There is much less data on this new approach in women with a natural ovarian insufficiency, which can be caused by different factors, including viral infection...
April 5, 2018: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/29610415/psychiatric-and-medical-conditions-in-transition-aged-individuals-with-asd
#10
Meghan N Davignon, Yinge Qian, Maria Massolo, Lisa A Croen
BACKGROUND AND OBJECTIVES: Children with autism spectrum disorder (ASD) have a variety of medical and psychiatric conditions and an increased use of health care services. There is limited information about the prevalence of psychiatric and medical conditions in adolescents and young adults with ASD. Our objective was to describe the frequency of medical and psychiatric conditions in a large population of diverse, insured transition-aged individuals with ASD. METHODS: Participants included Kaiser Permanente Northern California members who were enrolled from 2013 to 2015 and who were 14 to 25 years old...
April 2018: Pediatrics
https://www.readbyqxmd.com/read/29606319/repetitive-movements-and-behaviors-in-neurological-and-psychiatric-practice-distinctions-and-similarities-between-tourette-disorder-and-obsessive-compulsive-disorder
#11
REVIEW
A Hartmann, B Millet
Repetitive movements are the hallmark of chronic tic disorders such as Tourette disorder (TD), whereas repetitive behaviors are characteristic of obsessive-compulsive disorder (OCD). Both disorders tend to frequently co-occur, as a substantial number of patients with TD also suffer from OCD and vice versa. While the clinical distinction between tics and OCD is usually easy, there are borderline forms, and correct symptom recognition is vital for choosing the appropriate treatment modalities for each disorder, be they pharmacological, psychotherapeutic (behavioral therapy) or brain stimulation (deep brain stimulation, repetitive transcranial magnetic stimulation)...
March 29, 2018: Revue Neurologique
https://www.readbyqxmd.com/read/29605793/the-association-between-lifetime-cannabis-use-and-dysthymia-across-six-birth-decades
#12
Ofir Livne, Liat Razon, Jürgen Rehm, Deborah S Hasin, Shaul Lev-Ran
BACKGROUND: Though high rates of co-occurring cannabis use and depression are well-documented, data regarding the association between cannabis use and dysthymia is scarce. The aim of this cross-sectional study was to explore clinical correlations of cannabis use among individuals with dysthymia, as well as the changes in the association between cannabis use and dysthymia across six decades of birth cohorts. METHODS: Data were drawn from the National Epidemiologic Survey on Alcohol and Related Conditions-III (NESARC-III; 2012-2013; N = 36,309)...
March 16, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29604540/effects-of-co-occurring-marijuana-use-and-anxiety-on-brain-structure-and-functioning-a-systematic-review-of-adolescent-studies
#13
REVIEW
Mary Kathryn Cancilliere, Miryam Yusufov, Lisa Weyandt
The prevalence of marijuana use among adolescents with anxiety disorders in the USA is markedly high and well documented; however, the literature on this co-occurrence's effect on adolescent brain development and functioning is limited. This systematic review searched six databases to 1) explore the literature concerning marijuana use among adolescents with anxiety and 2) examine the effects of marijuana on brain structure and functioning. Overall, 27 studies from six countries were included in this review...
March 28, 2018: Journal of Adolescence
https://www.readbyqxmd.com/read/29602900/anxiety-and-mood-disorder-in-children-with-autism-spectrum-disorder-and-adhd
#14
Eliza Gordon-Lipkin, Alison R Marvin, J Kiely Law, Paul H Lipkin
OBJECTIVES: Autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD) frequently co-occur. Understanding the endophenotype of children with both ASD and ADHD may impact clinical management. In this study, we compare the comorbidity of anxiety and mood disorders in children with ASD, with and without ADHD. METHODS: We performed a cross-sectional study of children with ASD who were enrolled in the Interactive Autism Network, an Internet-mediated, parent-report, autism research registry...
March 30, 2018: Pediatrics
https://www.readbyqxmd.com/read/29602518/comorbid-mental-disorders-among-adults-in-the-mental-health-surveillance-survey
#15
Valerie L Forman-Hoffman, Kathryn R Batts, Sarra L Hedden, Kathy Spagnola, Jonaki Bose
PURPOSE: To examine the prevalence and correlates of mental disorder comorbidity in the adult U.S. household population. METHODS: Data are from a nationally representative sample of noninstitutionalized, civilian adults aged 18 years or older (n = 5653) who participated in the 2008-2012 Mental Health Surveillance Study. Mental disorders, including substance use disorders, were assessed by clinical interviewers using a semistructured diagnostic instrument. Analyses examined co-occurrence of mental disorders and associations with sociodemographic, functional impairment, and treatment correlates...
March 9, 2018: Annals of Epidemiology
https://www.readbyqxmd.com/read/29596721/substance-use-comorbidity-in-bipolar-disorder-a-qualitative-review-of-treatment-strategies-and-outcomes
#16
REVIEW
Alexandra K Gold, Michael W Otto, Thilo Deckersbach, Louisa G Sylvia, Andrew A Nierenberg, Gustavo Kinrys
BACKGROUND AND OBJECTIVES: Substance use disorders (SUDs) are present in up to 70% of patients with bipolar disorder (BD) and contribute to high rates of disability, morbidity, and treatment non-adherence. Despite this prevalence, few trials have investigated targeted psychosocial interventions for comorbid BD and SUDs. METHODS: Using PubMed and PsycINFO, we conducted a search of the literature up to January 2018 for psychosocial interventions targeted to patients with comorbid BD and SUDs...
April 2018: American Journal on Addictions
https://www.readbyqxmd.com/read/29592605/a-systematic-review-of-caregiver-implemented-mealtime-interventions-for-children-with-autism-spectrum-disorder
#17
Julie Diaz, Joanna Cosbey
Children with autism spectrum disorder (ASD) frequently have difficult mealtimes. A systematic review analyzed current evidence relevant to occupational therapy (OT) and mealtime interventions (a) for children with ASD, (b) occurring in the natural contexts, and (c) with parents/caregivers as interventionists. Database search identified 13 relevant articles. Each article was reviewed for practicality of implementation through a modified Feasibility, Appropriateness, Meaningfulness and Effectiveness (FAME) scale and for quality of research design using three measures specifically designed for single-case experimental design research...
March 1, 2018: OTJR: Occupation, Participation and Health
https://www.readbyqxmd.com/read/29588472/osteoarthritis-patterns-cardio-metabolic-risk-factors-and-risk-of-all-cause-mortality-20-years-follow-up-in-patients-after-hip-or-knee-replacement
#18
G Büchele, K P Günther, H Brenner, W Puhl, T Stürmer, D Rothenbacher, R E Brenner
Osteoarthritis (OA) is a common musculoskeletal disorder and occur in different patterns. However, its impact on long-term all-cause-mortality is inconclusive. STUDY AIMS: Investigate 20-year all-cause-mortality in patients with hip/knee arthroplasty (recruited 1995/1996, N = 809) from the Ulm Osteoarthritis Study-cohort, in comparison to general population. Furthermore, to enlighten the triangle between baseline life-style and cardio-metabolic risk factors, phenotypic OA-patterns (laterality, generalization, cause) and all-cause-mortality...
March 27, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29584904/combined-pathologies-in-ftld-tdp-types-a-and-c
#19
Tamar Gefen, Saman S Ahmadian, Qinwen Mao, Garam Kim, Mustafa Seckin, Borna Bonakdarpour, Eliana Marisa Ramos, Giovanni Coppola, Rosa Rademakers, Emily Rogalski, Alfred Rademaker, Sandra Weintraub, M-Marsel Mesulam, Changiz Geula, Eileen H Bigio
This study investigated the presence of combined pathologies in a large cohort of autopsies that show a primary pathologic diagnosis of phosphorylated 43-kDa TAR DNA-binding protein (FTLD-TDP), the majority of which portrayed clinical phenotypes consistent with primary progressive aphasia or behavioral variant frontotemporal dementia (bvFTD). Thirty-eight cases with FTLD-TDP (30 type-A and 8 type-C) were identified to determine characteristic differences between cases with and without combined pathologies. Findings indicated that combined pathologies co-occur with FTLD-TDP type-A at a high frequency (50%)-greater than when compared to FTLD-TDP type-C cases (12...
March 23, 2018: Journal of Neuropathology and Experimental Neurology
https://www.readbyqxmd.com/read/29580906/post-traumatic-psychiatric-disorders-ptsd-is-not-the-only-diagnosis
#20
Yann Auxéméry
Traumatic events and their consequences are often hidden or minimised by patients for reasons linked to the post-traumatic stress disorder itself (inexpressibility, shame, depressive thoughts, fear of stigmatisation, etc.). Although post-traumatic stress disorder (PTSD) remains the most widely known disorder, chronic post-traumatic psychiatric disorders are many and varied. After a trauma, the practitioner has to check for the different clinical forms of post-traumatic psychological consequences: PTSD is not the only diagnosis...
March 23, 2018: La Presse Médicale
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