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https://www.readbyqxmd.com/read/29045771/national-trends-in-and-correlates-of-nonmedical-use-of-prescription-stimulants-nonmedical-use-frequency-and-use-disorders
#1
Beth Han, Christopher M Jones, Carlos Blanco, Wilson M Compton
OBJECTIVE: To examine national trends in and correlates of nonmedical use of prescription stimulants, nonmedical use frequency, and use disorders among individuals aged 12-64 years. METHODS: Data from 783,400 persons aged 12-64 who participated in the 2003-2014 National Surveys on Drug Use and Health (NSDUH). Descriptive analyses and bivariable and multivariable logistic regression and zero-truncated negative binomial regression models were applied. RESULTS: Our multivariable results show that among individuals aged 12-64, the national prevalence of nonmedical use of prescription stimulants in 2003-2004 was higher than in 2007-2008 and was similar to that in 2009-2011, but was lower than in 2013-2014...
October 17, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29042341/pain-self-management-for-veterans-development-and-pilot-test-of-a-stage-based-mobile-optimized-intervention
#2
Sara S Johnson, Deborah A Levesque, Lynne E Broderick, Dustin G Bailey, Robert D Kerns
BACKGROUND: Chronic pain is a significant public health burden affecting more Americans than cardiovascular disease, diabetes, and cancer combined. Veterans are disproportionately affected by chronic pain. Among previously deployed soldiers and veterans, the prevalence of chronic pain is estimated between 44% and 60%. OBJECTIVE: The objective of this research was to develop and pilot-test Health eRide: Your Journey to Managing Pain, a mobile pain self-management program for chronic musculoskeletal pain for veterans...
October 17, 2017: JMIR Medical Informatics
https://www.readbyqxmd.com/read/29041969/glial-cells-are-functionally-impaired-in-juvenile-neuronal-ceroid-lipofuscinosis-and-detrimental-to-neurons
#3
Lotta Parviainen, Sybille Dihanich, Greg W Anderson, Andrew M Wong, Helen R Brooks, Rosella Abeti, Payam Rezaie, Giovanna Lalli, Simon Pope, Simon J Heales, Hannah M Mitchison, Brenda P Williams, Jonathan D Cooper
The neuronal ceroid lipofuscinoses (NCLs or Batten disease) are a group of inherited, fatal neurodegenerative disorders of childhood. In these disorders, glial (microglial and astrocyte) activation typically occurs early in disease progression and predicts where neuron loss subsequently occurs. We have found that in the most common juvenile form of NCL (CLN3 disease or JNCL) this glial response is less pronounced in both mouse models and human autopsy material, with the morphological transformation of both astrocytes and microglia severely attenuated or delayed...
October 17, 2017: Acta Neuropathologica Communications
https://www.readbyqxmd.com/read/29040946/neuropsychological-predictors-of-response-to-cognitive-behavioral-therapy-for-posttraumatic-stress-disorder-in-persons-with-severe-mental-illness
#4
Kim T Mueser, Susan R McGurk, Haiyi Xie, Elisa E Bolton, M Kay Jankowski, Weili Lu, Stanley D Rosenberg, Rosemarie Wolfe
This study examined whether cognitive functioning was related to treatment outcomes in persons with severe mental illness who received a cognitive behavioral therapy (CBT) program for co-occurring posttraumatic stress disorder (PTSD). The study sample was drawn from a larger controlled trial of 108 persons with severe mental illness and PTSD comparing the effects of CBT with treatment as usual on PTSD and related outcomes, with assessments conducted at baseline, post-treatment, and 3- and 6-month follow-ups...
October 6, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29038682/depression-as-a-moderator-of-stair-narrative-therapy-for-women-with-post-traumatic-stress-disorder-related-to-childhood-abuse
#5
Marylene Cloitre, Donn W Garvert, Brandon J Weiss
Background: Depression among those who have experienced childhood abuse is associated with earlier onset, more persistent and severe symptoms, more frequent relapse, and poorer treatment outcomes across a variety of psychiatric disorders. In addition, individuals with a history of childhood abuse are more likely to develop post-traumatic stress disorder (PTSD) co-occurring with depression. Objective: This study evaluated whether severity of depression moderated the outcome in a PTSD treatment for childhood abuse survivors...
2017: European Journal of Psychotraumatology
https://www.readbyqxmd.com/read/29035703/a-randomized-clinical-trial-examining-the-effects-of-an-anxiety-sensitivity-intervention-on-insomnia-symptoms-replication-and-extension
#6
Nicole A Short, Joseph W Boffa, Savannah King, Brian J Albanese, Nicholas P Allan, Norman B Schmidt
Insomnia disorder is impairing and prevalent, particularly among individuals with comorbid anxiety disorders. Despite the availability of effective computerized treatments for insomnia, there are few that target both insomnia as well as co-occurring anxiety symptoms. The current study tests the efficacy of a computerized treatment for anxiety sensitivity cognitive concerns, a transdiagnostic risk factor for anxiety, mood, and insomnia symptoms, against a repeated contact control, on reducing insomnia symptoms...
October 5, 2017: Behaviour Research and Therapy
https://www.readbyqxmd.com/read/29035515/the-isoform-specific-substrate-inhibition-mechanism-of-human-tryptophan-hydroxylase
#7
Kasper Damgaard Tidemand, Guenther H H J Peters, Pernille Harris, Eva Stensgaard, Hans E M Christensen
Tryptophan hydroxylase (TPH) catalyses the initial and rate-limiting step in the biosynthesis of serotonin, which is associated with a variety of disorders such as depression and irritable bowel syndrome. TPH exists in two isoforms; TPH1 and TPH2. TPH1 catalyses the initial step in the synthesis of serotonin in the peripheral tissues, while TPH2 catalyses this step in the brain. In this study, the steady-state kinetic mechanism for the catalytic domain of human TPH1 has been determined. Varying substrate tryptophan (Trp) and tetrahydrobiopterin (BH4) results in a hybrid Ping Pong-ordered mechanism in which the reaction can either occur through a Ping Pong or a sequential mechanism depending on the concentration of tryptophan...
October 16, 2017: Biochemistry
https://www.readbyqxmd.com/read/29033645/kleine-levine-syndrome-co-occuring-with-bipolar-disorder
#8
COMMENT
Ahmet Tiryaki, Filiz Civil Arslan, Mihriban Yildirim
No abstract text is available yet for this article.
September 2017: Noro Psikiyatri Arsivi
https://www.readbyqxmd.com/read/29032702/a-change-in-perspective-from-dual-diagnosis-to-multimorbidity
#9
Ish P Bhalla, Robert A Rosenheck
OBJECTIVE: There has been increasing interest within psychiatry in the concept of multimorbidity because psychiatric patients typically present with multiple concurrent disorders, these disorders mutually exacerbate one another, and their interaction shapes treatment options. Metrics have not been developed to document multimorbidity in psychiatric clinical practice. METHODS: Four classes of indicators relevant to multimorbidity were defined and evaluated among veterans treated in mental health specialty clinics nationally in the Veterans Health Administration (VHA) in fiscal year 2012...
October 16, 2017: Psychiatric Services: a Journal of the American Psychiatric Association
https://www.readbyqxmd.com/read/29031492/comprehensive-vs-assisted-management-of-mood-and-pain-symptoms-cammps-trial-study-design-and-sample-characteristics
#10
Kurt Kroenke, Erica Evans, Sharon Weitlauf, Stephanie McCalley, Brian Porter, Tabeel Williams, Fitsum Baye, Spencer G Lourens, Marianne S Matthias, Matthew J Bair
BACKGROUND: Pain is the most common presenting somatic symptom in medical outpatients, and depression and anxiety are the two most common mental disorders. They frequently co-occur, are under-treated, and result in substantial disability and reduced health-related quality of life. OBJECTIVES: The Comprehensive vs. Assisted Management of Mood and Pain Symptoms (CAMMPS) study is a randomized comparative effectiveness trial designed to test the relative effectiveness of a lower-resource vs...
October 11, 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/29024518/cd5-b-lymphoproliferative-disorder-with-subsequent-development-of-plasma-cell-leukaemia-diagnostic-and-aetiologic-reasoning
#11
Evdoxia Gounari, Georgia Kaiafa, Triantafyllia Koletsa, Vasiliki Tsavdaridou, Ioannis Kostopoulos, Lilian Toptsi, Lemonia Skoura
BACKGROUND: Plasma cell myeloma (PCM) has been sporadically reported to occur simultaneously or subsequently to mature B lymphoproliferative disorders (LPDs), predominantly chronic lymphocytic leukaemia (CLL). METHODS: We describe the clinical and laboratory findings of a 69-year-old male patient who developed plasma cell leukaemia (PCL) 8 years after an initial diagnosis of a low stage CD5+ B LPD and 3 years after treatment for LPD. RESULTS: The transition from a clinically indolent B LPD to an aggressive PCM was documented by bone marrow (BM) biopsy, while flow cytometric (FC) immunophenotyping conferred additional information by disclosing the co-existence of both disorders in BM and the presence of abnormal monotypic PCs in peripheral blood above PCL levels...
October 10, 2017: Cytometry. Part B, Clinical Cytometry
https://www.readbyqxmd.com/read/29021112/american-counselors-acceptance-of-non-abstinence-outcome-goals-for-clients-diagnosed-with-co-occurring-substance-use-and-other-psychiatric-disorders
#12
Alan K Davis, Harold Rosenberg, Joseph A Rosansky
Previous research has examined clinicians' acceptance of non-abstinence for clients who have a substance use disorder (SUD), but many SUD clients also present with a psychiatric disorder. To evaluate the acceptability of non-abstinence as a final outcome goal for clients with co-occurring diagnoses, we recruited a nationwide sample of 751 American substance abuse counselors to complete a web-based questionnaire. Respondents rated the acceptability of limited/moderate consumption by clients diagnosed with each of 18 co-occurring disorders: three psychiatric disorders (Major Depressive Disorder, Post-Traumatic Stress Disorder, Social Phobia) x three substances (alcohol, cannabis, opioids) x two levels of severity (DSM-5 Moderate SUD, DSM-5 Severe SUD)...
November 2017: Journal of Substance Abuse Treatment
https://www.readbyqxmd.com/read/29018367/treatment-of-comorbid-alcohol-dependence-and-anxiety-disorder-review-of-the-scientific-evidence-and-recommendations-for-treatment
#13
REVIEW
Carmen Gimeno, Marisa Luisa Dorado, Carlos Roncero, Nestor Szerman, Pablo Vega, Vicent Balanzá-Martínez, F Javier Alvarez
Patients with alcohol-use disorders (AUDs) have a high prevalence of anxiety disorders (AnxDs). "Co-occurring disorders" refers to the coexistence of an AUD and/or drug related disorders with another non-addictive psychiatric disorder. The aim of this study was to assess the effectiveness of psychopharmacological treatments and psychotherapy in patients with AUD and AnxD and to propose recommendations for the treatment of patients with comorbid AnxDs and AUDs. Randomized clinical trials, meta-analyses, and clinical guidelines were retrieved from PubMed, Embase, and Cochrane databases...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28992894/chronic-prostatitis-and-comorbid-non-urological-overlapping-pain-conditions-a-co-twin-control-study
#14
Marianna Gasperi, John N Krieger, Christopher Forsberg, Jack Goldberg, Dedra Buchwald, Niloofar Afari
OBJECTIVES: Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is characterized by pain and voiding symptoms in the absence of an obvious infection or other cause. CP/CPPS frequently occurs with non-urological chronic overlapping pain conditions (COPCs) of unknown etiology. We conducted a co-twin control study in men discordant for chronic prostatitis (CP), an overarching diagnosis of which approximately 90% is CP/CPPS. The primary aim was to investigate the contribution of familial factors, including shared genetic and common environmental factors, to the comorbidity of CP and COPCs...
November 2017: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/28990883/learning-to-address-multiple-syndemics-for-people-living-with-hiv-through-client-perspectives-on-cbt
#15
Nicholas S Perry, Jocelyn E Remmert, Christina Psaros, Megan Pinkston, Steven A Safren
OBJECTIVE: The mental health burden among people living with HIV/AIDS (PLWHA) is high and often involves multiple comorbid psychological and substance use-related psychosocial problems. These co-occurring problems, or syndemics, additively impair engagement in HIV disease management. Existing psychotherapies for mental health and HIV health have generally focused on a single psychosocial problem and little research exists to guide future psychotherapies that address multiple mental health issues...
October 9, 2017: Psychotherapy Research: Journal of the Society for Psychotherapy Research
https://www.readbyqxmd.com/read/28988573/alcohol-s-effects-on-the-brain-neuroimaging-results-in-humans-and-animal-models
#16
Natalie M Zahr, Adolf Pfefferbaum
Brain imaging technology has allowed researchers to conduct rigorous studies of the dynamic course of alcoholism through periods of drinking, sobriety, and relapse and to gain insights into the effects of chronic alcoholism on the human brain. Magnetic resonance imaging (MRI) studies have distinguished alcohol-related brain effects that are permanent from those that are reversible with abstinence. In support of postmortem neuropathological studies showing degeneration of white matter, MRI studies have shown a specific vulnerability of white matter to chronic alcohol exposure...
2017: Alcohol Research: Current Reviews
https://www.readbyqxmd.com/read/28986562/ultrafast-giant-magnetic-cooling-effect-in-ferromagnetic-co-pt-multilayers
#17
Je-Ho Shim, Akbar Ali Syed, Chul-Hoon Kim, Kyung Min Lee, Seung-Young Park, Jong-Ryul Jeong, Dong-Hyun Kim, Dong Eon Kim
The magnetic cooling effect originates from a large change in entropy by the forced magnetization alignment, which has long been considered to be utilized as an alternative environment-friendly cooling technology compared to conventional refrigeration. However, an ultimate timescale of the magnetic cooling effect has never been studied yet. Here, we report that a giant magnetic cooling (up to 200 K) phenomenon exists in the Co/Pt nano-multilayers on a femtosecond timescale during the photoinduced demagnetization and remagnetization, where the disordered spins are more rapidly aligned, and thus magnetically cooled, by the external magnetic field via the lattice-spin interaction in the multilayer system...
October 6, 2017: Nature Communications
https://www.readbyqxmd.com/read/28984746/late-reduction-of-cocaine-cravings-in-a-randomized-double-blind-trial-of-aripiprazole-vs-perphenazine-in-schizophrenia-and-comorbid-cocaine-dependence
#18
Thomas Beresford, Jennifer Buchanan, Elizabeth Brie Thumm, Chad Emrick, David Weitzenkamp, Patrick J Ronan
PURPOSE: Co-occurring schizophrenia spectrum disorder and International Statistical Classification of Diseases, 10th Revision cocaine dependence present a particularly destructive constellation that is often difficult to treat. Both conditions raise dopamine transmission effects in the brain. Traditional neuroleptics block dopamine receptors, whereas aripiprazole modulates dopamine activity as an agonist/antagonist. We tested whether dopamine modulation is superior to dopamine blocking in dual-diagnosis patients...
October 3, 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28984294/perinatal-immune-activation-produces-persistent-sleep-alterations-and-epileptiform-activity-in-male-mice
#19
Galen Missig, Emery L Mokler, James O Robbins, Abigail J Alexander, Christopher J McDougle, William A Carlezon
Increasing evidence suggests a role for inflammation in neuropsychiatric conditions including autism spectrum disorder (ASD). Previous work in rodents has established that immune activation during critical developmental periods can cause phenotypes that reproduce core features of ASD, including decreased social interaction, aberrant communication, and increased repetitive behavior. In humans, ASD is frequently associated with co-morbid medical conditions including sleep disorders, motor hyperactivity, and seizures...
October 6, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28983872/pearls-and-pitfalls-of-optical-coherence-tomography-angiography-in-the-multimodal-evaluation-of-uveitis
#20
REVIEW
Francesco Pichi, David Sarraf, Mariachiara Morara, Shahana Mazumdar, Piergiorgio Neri, Vishali Gupta
BACKGROUND: Optical coherence tomography angiography (OCTA) employs a novel imaging algorithm that detects the amplitude or phase decorrelation of blood cell movement. It thus provides a flow map with depth-resolved visualization of the various vascular layers in the posterior pole of the eye including the retina capillary plexus and the choroid. In the past 3 years, the number of research papers on the subject of OCTA in retinal diseases has grown exponentially including important applications in the field of uveitis...
October 5, 2017: Journal of Ophthalmic Inflammation and Infection
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