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https://www.readbyqxmd.com/read/28635543/anxiety-modulates-the-relation-between-attention-deficit-hyperactivity-disorder-severity-and-working-memory-related-brain-activity
#1
Dennis van der Meer, Pieter J Hoekstra, Daan van Rooij, Anderson M Winkler, Hanneke van Ewijk, Dirk J Heslenfeld, Jaap Oosterlaan, Stephen V Faraone, Barbara Franke, Jan K Buitelaar, Catharina A Hartman
OBJECTIVES: Individuals with attention-deficit/hyperactivity disorder (ADHD) often have heightened levels of anxiety, which has been associated with worse performance on working memory tasks. Knowledge of the neural pathways underlying the combined presence of ADHD and anxiety may aid in a better understanding of their co-occurrence. Therefore, we investigated how anxiety modulates the effect of ADHD severity on neural activity during a visuospatial working memory (VSWM) task. METHODS: Neuroimaging data were available for 371 adolescents and young adults participating in the multicentre cohort study NeuroIMAGE (average age 17...
March 1, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28632095/transgressing-gender-norms-in-addiction-treatment-transgender-rights-to-access-within-gender-segregated-facilities
#2
Sara Matsuzaka
Despite having disproportionately high rates of substance use disorder and co-occurring health and mental health issues compared to the general population, transgender individuals experience significant barriers to accessing and engaging in addiction treatment programs. Inpatient addiction treatment centers were originally designed to treat substance-dependent heterosexual cisgender populations and, as such, feature gender-segregated housing, bathrooms, and treatment sessions. The heteronormative structural and programmatic barriers, combined with exposures to stigmatic and prejudicial attitudes, may dissuade transgender populations from benefiting from the addiction treatment they so direly need...
February 15, 2017: Journal of Ethnicity in Substance Abuse
https://www.readbyqxmd.com/read/28626941/binding-of-canonical-wnt-ligands-to-their-receptor-complexes-occurs-in-ordered-plasma-membrane-environments
#3
Erdinc Sezgin, Yagmur Azbazdar, Xue Wen Ng, Cathleen Teh, Kai Simons, Gilbert Weidinger, Thorsten Wohland, Christian Eggeling, Gunes Ozhan
While the cytosolic events of Wnt/β-catenin signaling (canonical Wnt signaling) pathway have been widely studied, only little is known about the molecular mechanisms involved in Wnt binding to its receptors at the plasma membrane. Here, we reveal the influence of the immediate plasma membrane environment on the canonical Wnt-receptor interaction. While the receptors are distributed both in ordered and disordered environments, Wnt binding to its receptors selectively occurs in more ordered membrane environments which appear to co-internalize with the Wnt-receptor complex...
June 19, 2017: FEBS Journal
https://www.readbyqxmd.com/read/28622812/clozapine-induced-gastrointestinal-hypomotility-a-potentially-life-threatening-adverse-event-a-review-of-the-literature
#4
REVIEW
Stephen West, David Rowbotham, Glen Xiong, Chris Kenedi
OBJECTIVE: The haematological and cardiac complications of clozapine have been well documented. Recent evidence from pharmacovigilance databases suggests that gastrointestinal (GI) complications are the leading cause of clozapine related deaths. This review aims to describe clinical features along with preventative and treatment options. METHOD: A review of MEDLINE via PubMed searching for all articles published up to February of 2016. Inclusion criteria were articles that provided clinical or epidemiological information relating to the diagnosis, outcome, management or pathophysiology of clozapine related gastrointestinal disorders in humans...
May 2017: General Hospital Psychiatry
https://www.readbyqxmd.com/read/28620713/angiopoietin-receptor-tek-interacts-with-cyp1b1-in-primary-congenital-glaucoma
#5
Meha Kabra, Wei Zhang, Sonika Rathi, Anil K Mandal, Sirisha Senthil, Goutham Pyatla, Muralidhar Ramappa, Seema Banerjee, Konegari Shekhar, Srinivas Marmamula, Asha L Mettla, Inderjeet Kaur, Rohit C Khanna, Hemant Khanna, Subhabrata Chakrabarti
Primary congenital glaucoma (PCG) is a severe autosomal recessive ocular disorder associated with considerable clinical and genetic heterogeneity. Recently, rare heterozygous alleles in the angiopoietin receptor-encoding gene TEK were implicated in PCG. We undertook this study to ascertain the second mutant allele in a large cohort (n = 337) of autosomal recessive PCG cases that carried heterozygous TEK mutations. Our investigations revealed 12 rare heterozygous missense mutations in TEK by targeted sequencing...
June 15, 2017: Human Genetics
https://www.readbyqxmd.com/read/28618296/impaired-body-perception-in-developmental-prosopagnosia
#6
Federica Biotti, Katie L H Gray, Richard Cook
Developmental prosopagnosia (DP) is a lifelong neurodevelopmental disorder associated with difficulties recognising and discriminating faces. In some cases, the perceptual deficits seen in DP appear to be face-specific. However, DP is known to be a heterogeneous condition, and many cases undoubtedly exhibit impaired perception of other complex objects. There are several well-documented parallels between body and face perception; for example, faces and bodies are both thought to recruit holistic analysis and engage similar regions of visual cortex...
May 25, 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/28616935/service-use-and-unmet-needs-for-substance-use-and-mental-disorders-in-canada
#7
Karen Urbanoski, Dakota Inglis, Scott Veldhuizen
OBJECTIVE: To investigate patterns and predictors of help seeking and met/unmet needs for mental health care in a national population health survey. METHOD: Participants were respondents to the 2012 Canadian Community Health Survey on Mental Health (CCHS-MH; n = 25,133). We used regression to identify the diagnostic and sociodemographic predictors of the use of informal supports, primary care, and specialist care, as well as perceived unmet needs. RESULTS: Eleven percent of Canadians reported using professionally led services for mental health or substance use in 2012, while another 9% received informal supports...
January 1, 2017: Canadian Journal of Psychiatry. Revue Canadienne de Psychiatrie
https://www.readbyqxmd.com/read/28616537/congenital-arch-vessel-anomalies-in-charge-syndrome-a-frequent-feature-with-risk-for-co-morbidity
#8
Nicole Corsten-Janssen, Conny M A van Ravenswaaij-Arts, Livia Kapusta
BACKGROUND: CHARGE syndrome is a complex multiple congenital malformation disorder with variable expression that is caused by mutations in the CHD7 gene. Variable heart defects occur in 74% of patients with a CHD7 mutation, with an overrepresentation of atrioventricular septal defects and conotruncal defects - including arch vessel anomalies. METHODS AND RESULTS: We report an index patient with an arch vessel anomaly underlying serious feeding problems that resolved after arch vessel surgery...
September 2016: IJC Heart & Vasculature
https://www.readbyqxmd.com/read/28615309/the-frequent-and-underrecognised-co-occurrence-of-acute-exacerbated-copd-and-depression-warrants-screening-a-systematic-review
#9
REVIEW
Leopold Lecheler, Maximilian Richter, Daniel P Franzen, Silvana K Rampini, Marcus Cheetham, Josef Jenewein, Edouard Battegay, Albina Nowak
Patients with acute exacerbated chronic obstructive pulmonary disease (AECOPD) and concurrent depression suffer significant psychological stress and decreased quality of life. The aim of this study was to collate data, guidelines and recommendations from publications on the screening and management of depressive mood disorders in patients hospitalised with AECOPD.We systematically searched four databases for publications reporting screening or management of depression in patients hospitalised for AECOPD. The identification of articles was based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement...
June 30, 2017: European Respiratory Review: An Official Journal of the European Respiratory Society
https://www.readbyqxmd.com/read/28614965/the-co-occurrence-of-autism-spectrum-disorder-in-children-with-adhd
#10
Benjamin Zablotsky, Matthew D Bramlett, Stephen J Blumberg
OBJECTIVE: Children with ADHD frequently present with autism spectrum disorder (ASD) symptomatology, yet there is a notable gap in the treatment needs of this subpopulation, including whether the presence of ASD may be associated with more severe ADHD symptoms. METHOD: Data from the 2014 National Survey of the Diagnosis and Treatment of ADHD and Tourette Syndrome ( n = 2,464) were used to compare children diagnosed with ADHD and ASD with children with ADHD, but not ASD...
June 1, 2017: Journal of Attention Disorders
https://www.readbyqxmd.com/read/28614761/associations-of-phthalates-exposure-with-attention-deficits-hyperactivity-disorder-a-case-control-study-among-chinese-children
#11
Dan Hu, Yi-Xin Wang, Wen-Jing Chen, Yu Zhang, Hong-Hui Li, Li Xiong, Hui-Ping Zhu, Hong-Yan Chen, Song-Xu Peng, Zhi-Hua Wan, Yan Zhang, Yu-Kai Du
Researches on associations between phthalates exposure and child attention deficit hyperactivity disorder (ADHD) are inconsistent. This study aimed to evaluate the associations of urinary phthalates with ADHD, co-occurring oppositional defiant disorder (ODD), related symptoms and behavior problems among Chinese children. We enrolled 225 ADHD cases and 225 healthy controls aged 6-13 years old in Liuzhou, China. Each child provided repeated urine samples at 4 visits. Eight phthalate metabolites were measured by high-performance liquid chromatography and tandem mass spectrometry...
June 11, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28613971/cognitive-behavior-therapy-self-help-booklet-to-decrease-depression-and-alcohol-use-among-people-with-alcohol-dependence-in-thailand
#12
Darawan Thapinta, Sombat Skulphan, Voranut Kitsumban, Chaowanee Longchoopol
Individuals with disorders co-occurring of depression and alcohol dependence are clinically more complex and more difficult to keep well than those diagnosed with either depression or alcohol dependence alone. Cognitive behavior therapy (CBT) has shown to help reduce patients' symptoms of depression and alcohol use. The aim of this study was to evaluate the effectiveness of a CBT self-help booklet (CBT-SHB) with usual care in decreasing depression and alcohol use among people with co-occurring alcohol dependence and mild depression...
June 14, 2017: Issues in Mental Health Nursing
https://www.readbyqxmd.com/read/28609312/comorbid-ptsd-and-social-anxiety-disorder-associations-with-quality-of-life-and-suicide-attempts
#13
Katherine A McMillan, Gordon J G Asmundson, Jitender Sareen
Posttraumatic stress disorder (PTSD) and social anxiety disorder (SAD) frequently co-occur. Preliminary data from treatment-seeking and veteran samples suggest that the impact of PTSD-SAD comorbidity may be additive, conferring distress and impairment beyond that of either disorder alone. The current study sought to clarify and extend existent research using wave 2 of the National Epidemiologic Survey of Alcohol and Related Conditions, an epidemiological sample of American adults. Individuals who met criteria for comorbid PTSD-SAD were compared to those with either disorder alone on measures of lifetime suicide attempts or quality of life as measured by the Medical Outcomes Study Questionnaire...
June 12, 2017: Journal of Nervous and Mental Disease
https://www.readbyqxmd.com/read/28606462/growing-literature-but-limited-evidence-a-systematic-review-regarding-prebiotic-and-probiotic-interventions-for-those-with-traumatic-brain-injury-and-or-posttraumatic-stress-disorder
#14
Lisa A Brenner, Kelly A Stearns-Yoder, Adam S Hoffberg, Molly E Penzenik, Amy J Starosta, Theresa D Hernández, Daniel A Hadidi, Christopher A Lowry
Traumatic brain injury (TBI) is highly prevalent among a wide-range of populations, including civilians, military personnel, and Veterans. TBI sequelae may be further exacerbated by symptoms associated with frequently occurring co-morbid psychiatric conditions including posttraumatic stress disorder (PTSD). This is particularly true among the population of military personnel from recent conflicts in Iraq and Afghanistan with a history of mild TBI (mTBI) and PTSD. The need for efficacious treatments for TBI and co-morbid PTSD is significant, and evidence-based interventions for these frequently co-occurring conditions are limited...
June 9, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28603908/depression-profile-in-cancer-patients-and-patients-without-a-chronic-somatic-disease
#15
Christoph Nikendei, Valentin Terhoeven, Johannes C Ehrenthal, Imad Maatouk, Beate Wild, Wolfgang Herzog, Hans-Christoph Friederich
OBJECTIVE: To investigate whether depressed oncology patients show a specific depressive symptom profile, we compared depression symptoms in depressed cancer patients (CANCER-DEP) and depressed patients without a chronic somatic disease (NONCANCER-DEP). METHODS: Of a total of 2493 outpatients from a comprehensive cancer center and a center for psychosocial medicine, 1054 (42.3%) met the DSM-5 criteria for depression, measured with the patient health questionnaire (PHQ-9)...
June 11, 2017: Psycho-oncology
https://www.readbyqxmd.com/read/28601668/developmental-and-clinical-predictors-of-comorbidity-for-youth-with-obsessive-compulsive-disorder
#16
Tara S Peris, Michelle Rozenman, R Lindsey Bergman, Susanna Chang, Joseph O'Neill, John Piacentini
OBJECTIVE: To date, few studies of childhood obsessive compulsive disorder (OCD) have been adequately powered to examine patterns and predictors of comorbidity, despite the frequency with which it occurs. We address this gap, drawing on a large sample of youth with OCD who were systematically assessed through research and clinical programs in a university-based specialty program for children and adolescents with OCD. We examine patterns of comorbidity across different epochs of development and predict specific classes of OCD (comorbidity internalizing/externalizing/both) from key demographic and clinical variables that may be useful in guiding individualized treatment...
October 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28601136/psychiatric-aspects-of-lung-disease-in-critical-care
#17
REVIEW
Yelizaveta Sher
Respiratory conditions are some of the most common indications for admission to critical care units. Psychiatric disorders and symptoms are highly comorbid with lung disease. They can occur as a risk factor to lung disease, as a co-occurring condition, as a consequence of a pulmonary condition, or as a treatment side effect either from medications or assistive devices. Patients can experience a myriad of mood, anxiety, and cognitive disorder symptoms and conditions in critical care units. Intensivists and psychiatrists must be aware of the interplay between pulmonary and psychiatric symptoms as well as medication effects and interactions...
July 2017: Critical Care Clinics
https://www.readbyqxmd.com/read/28600897/examination-of-cumulative-effects-of-early-adolescent-depression-on-cannabis-and-alcohol-use-disorder-in-late-adolescence-in-a-community-based-cohort
#18
Isaac C Rhew, Charles B Fleming, Ann Vander Stoep, Semret Nicodimos, Cheng Zheng, Elizabeth McCauley
BACKGROUND AND AIMS: Although they often co-occur, the longitudinal relationship between depression and substance use disorders during adolescence remains unclear. This study estimated the effects of cumulative depression during early adolescence (ages 13-15) on the likelihood of cannabis use disorder (CUD) and alcohol use disorder (AUD) at age 18. DESIGN: Prospective cohort study of youth assessed at least annually between 6(th) and 9(th) grade (~ age 12 to 15) and again at age 18...
June 10, 2017: Addiction
https://www.readbyqxmd.com/read/28600751/central-and-peripheral-nervous-system-disorders-following-ivermectin-mass-administration-a-descriptive-study-based-on-the-democratic-republic-of-congo-pharmacovigilance-system
#19
Didier Nzolo, Francis Anto, Sarah Hailemariam, Didier Bakajika, Daniel Muteba, Jean-Claude Makenga, Gautier Mesia, Celestin Nsibu, Samuel Mampunza, Gaston Tona
INTRODUCTION: The mainstay of onchocerciasis control currently is mass administration of ivermectin; however, this may be associated with serious adverse events, including deaths, when administered in areas where onchocerciasis and loiasis are co-endemic. OBJECTIVES: The objective of the current study was to describe the central and peripheral nervous system disorders that occurred after mass administration of ivermectin in Democratic Republic of Congo (DRC). METHODS: This is a retrospective descriptive study involving a review of data on adverse events related to mass administration of ivermectin...
June 9, 2017: Drugs—Real World Outcomes
https://www.readbyqxmd.com/read/28599899/the-placenta-accreta-spectrum-pathophysiology-and-evidence-based-anatomy-for-prenatal-ultrasound-imaging
#20
REVIEW
Eric Jauniaux, Sally Collins, Graham J Burton
The placenta accreta spectrum (PAS) is a complex obstetric complication associated with a high maternal morbidity. It is a relatively new disorder of placentation, and is the consequence of damage to the endometrium-myometrial interface of the uterine wall. When first described 80 years ago, it mainly occurred after manual removal of the placenta, uterine curettage or endometritis. Superficial damage leads primarily to an abnormally adherent placenta, and is diagnosed as the complete or partial absence of the decidua on histology...
June 6, 2017: American Journal of Obstetrics and Gynecology
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