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herbal antiepileptics

Hong-Dan Zhan, Hai-Yu Zhou, Yun-Peng Sui, Xin-Liang Du, Wei-Hao Wang, Li Dai, Feng Sui, Hai-Ru Huo, Ting-Liang Jiang
ETHNOPHARMACOLOGICAL RELEVANCE: Gastrodia elata Blume (Orchidaceae) is commonly called Tian ma in Chinese and mainly distributed in the mountainous areas of eastern Asia, such as China, Korea, Japan and India. It is an extensively used traditional Chinese herbal medicine in the clinical practice of traditional Chinese medicine, to treat headache, migraine, dizziness, epilepsy, infantile convulsion, tetany and so on. The present paper reviews the advancements in investigation of botany and ethnopharmacology, phytochemistry, pharmacology, toxicology and quality control of Gastrodia elata Blume...
August 2, 2016: Journal of Ethnopharmacology
Zahra Gholamnezhad, Shahrzad Havakhah, Mohammad Hossein Boskabady
ETHNOPHARMACOLOGICAL RELEVANCE: Nigella sativa (N. sativa) L. (Ranunculaceae), well known as black cumin, has been used as a herbal medicine that has a rich historical background. It has been traditionally and clinically used in the treatment of several diseases. Many reviews have investigated this valuable plant, but none of them focused on its clinical effects. Therefore, the aim of the present review is to provide a comprehensive report of clinical studies on N. sativa and some of its constituents...
August 22, 2016: Journal of Ethnopharmacology
Jinsoo Lee, Kwanghyun Son, Gwiseo Hwang, Moonju Kim
Objective. Herbal medicine has been widely used to treat drug resistant epilepsy. Shihogyejitang (SGT) has been commonly used to treat epilepsy. We investigated the effect and safety of SGT in children with drug resistant epilepsy. Design. We reviewed medical records of 54 patients with epilepsy, who failed to respond to at least two antiepileptic drugs and have been treated with SGT between April 2006 and June 2014 at the Department of Pediatric Neurology, I-Tomato Hospital, Korea. Effect was measured by the response rate, seizure-free rate, and retention rate at six months...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
Shilu Mathew, Muhammad Faheem, Abdulrahman L Al-Malki, Taha A Kumosani, Ishtiaq Qadri
Epilepsy is a neurological disorder affecting more than 50 million people worldwide. It can be controlled by antiepileptic drugs (AEDs) but more than 30% patients are still resistant to AEDs. To overcome this problem, researchers are trying to develop novel approaches to treat epilepsy including the use of herbal medicines. The γ-amino butyric acid type-A receptor associated protein (GABARAP) is ubiquitin-like modifier implicated in the intracellular trafficking of GABAAR. An in silico mutation was created at 116 amino acid position G116A, and an in silico study was carried out to identify the potential binding inhibitors (with antiepileptic properties) against the active sites of GABARAP...
2015: Bioinformation
Jacek Drobnik, Andréia Barroncas de Oliveira
ETHNOPHARMACOLOGICAL RELEVANCE: Cissus verticillata (L.) Nicolson and C.E. Jarvis is best known for its hypoglycaemic and anti-lipemic action. In Brazilian ethnopharmacy it is called "plant-insulin" and used mostly against diabetes, as well as in abscesses, haemorrhage and epilepsy. In the present paper we study the past significance of this plant recorded between 1571 and 1829 both in ethnic (Mexico, Haiti) and official (European) pharmacies. AIM OF THE STUDY: (1) We are able to identify Carolus Sanctus and Lupulus Mechiocanus from Renaissance and later sources as Cissus verticillata...
August 2, 2015: Journal of Ethnopharmacology
Nikolaus J Sucher, Maria C Carles
Epilepsy is the most common chronic neurological disease, affecting about 1% of the world's population during their lifetime. Most people with epilepsy can attain a seizure-free life upon treatment with antiepileptic drugs (AEDs). Unfortunately, seizures in up to 30% do not respond to treatment. It is estimated that 90% of people with epilepsy live in developing countries, and most of them receive no drug treatment for the disease. This treatment gap has motivated investigations into the effects of plants that have been used by traditional healers all over the world to treat seizures...
November 2015: Epilepsy & Behavior: E&B
Shagun Dubey, Aditya Ganeshpurkar, Divya Bansal, Nazneen Dubey
AIM: The severity of adverse reactions due to antiepileptics is observed during initiation and early treatment in which impairment of cognitive effects are common. Since long time, herbal medicine is a natural remedy to treat neural symptoms. Phytochemicals have been proven to be potent neuro-protective agents. Rutin, a bioflavonoid is established to be nootropic in many studies. In this study, we aimed to determine the protective effect of rutin in zebrafish against the side effects produced by AEDs...
January 2015: Indian Journal of Pharmacology
Paramdeep Singh, Damanpreet Singh, Rajesh Kumar Goel
Oxidative stress, together with mitochondrial dysfunction, has been reported to be involved in the pathogenesis of epileptogenesis and its associated comorbidities. Phytoflavonoids have shown numerous beneficial ameliorative effects on different neurological disorders by virtue of their antioxidant effect. The present study investigated the effect of flavonoid-rich ethyl acetate fraction of the crude fig extract of Ficus religiosa in combination with phenytoin on seizure severity, depressive behavior, and cognitive deficit in pentylenetetrazol (PTZ)-kindled mice...
December 2014: Epilepsy & Behavior: E&B
Mohammad Rostampour, Arghavan Ghaffari, Peyman Salehi, Farshid Saadat
INTRODUCTION: Regarding chronic nature of epilepsy and its side effects and to access the effective treatment procedures, herbal medicine has received remarkable interest. The aim of this study was to determine the anticonvulsant effects of hydro-alcoholic extract of Anethum graveolens seed on pentylenetetrazol (PTZ) -induced seizure in male mice. METHODS: Fifty-six albino male mice were divided randomly into seven groups including the negative control (saline), positive control (Phenobarbital) and treatment groups using different doses of hydro-alcoholic extract of Anethum graveolens seed (50, 100, 300, 500 and 1000 mg/ kg)...
2014: Basic and Clinical Neuroscience
Guadalupe Piñeiro Corrales, Cristina Vázquez López, Miriam Álvarez Payero
Clinical manifestations accompanying neurological diseases are diverse and affect multiple organs. Nutritional status of patients with certain neurological diseases such as stroke, Alzheimer's disease, Parkinson's disease, Epilepsy and Multiple Sclerosis can be altered because of symptoms associated with disease course, including certain micronutrient deficiency (folic acid, zinc, vitamin B6 and B12, vitamin D, vitamin E and vitamin C), changes in energy expenditure, intake decreased, gastrointestinal disorders and dysfunction of the bone mass...
2014: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
Tido von Schoen-Angerer, René Madeleyn, Gunver Kienle, Helmut Kiene, Jan Vagedes
Viscum album (European mistletoe) extracts have known immunomodulatory effects but little data exist on anticonvulsant activity despite its usefulness having been reported for centuries. A 4½-year-old girl with childhood absence epilepsy and global developmental delay was treated with different antiepileptic drugs and ketogenic diet but failed to become seizure free over a 2-year period. She also received different herbal remedies as part of an integrative medicine approach. Initial improvement occurred on valproate-ethosuximide, a further improvement was seen after adding clobazam to valproate...
July 2015: Journal of Child Neurology
Shamim Sahranavard, Saeedeh Ghafari, Mahmoud Mosaddegh
Antiepileptic drugs used to treat epilepsy can cause severe, life threatening side effects. In Iranian traditional medicine, herbal remedies have been used for centuries to treat seizures. In this study, the five most important herbals in Iranian traditional medicine, namely Canon, al-Hawi, al-Abniah 'an Haqaeq al Adwia, Tuhfat al-Mu'minin, and Makhzan ul-Adwia, were searched for the term "sar-e", which means epilepsy, to identify the herbs used for treatment in ancient times. We also searched scientific literature for pharmacological evidence of their effectiveness...
May 2014: Seizure: the Journal of the British Epilepsy Association
Hui-Ling Zhu, Jian-Bo Wan, Yi-Tao Wang, Bao-Cai Li, Cheng Xiang, Jing He, Peng Li
OBJECTIVE: Epilepsy is a serious neural disease that affects around 50 million people all over the world. Although for the majority patients with epilepsy, seizures are well controlled by currently available antiepileptic drugs (AEDs), there are still >30% of patients suffered from medically refractory epilepsy and approximately 30-40% of all epileptic patients affected by numerous side effects and seizure resistance to the current AEDs. Therefore, many researchers try to develop novel approaches to treat epilepsy, for example, to discover new antiepileptic constituents from herbal medicines...
January 2014: Epilepsia
Zahra Kiasalari, Mohsen Khalili, Mehrdad Roghani, Azam Sadeghian
Considering the high rate of epilepsy today, with respect to the insufficiency of the available therapies, new strategies and methods are recommended for medical treatment of epileptic patients. Therefore, the present study experimentally investigated the anticonvulsant effect of a herbal medicine candidate brassica nigra, by using kindling method. Sixty male mice were randomly selected and divided into six experimental groups (n = 10) including: 1-control, 2-pentylentetrazole (PTZ)-kindled mice, 3-positive control group received valproate (100 mg/Kg) as anti-convulsant drug, 4-5 and 6 received brassica nigra seed extract in three doses (75, 150 and 300 mg/Kg; IP)...
2012: Iranian Journal of Pharmaceutical Research: IJPR
Jyotsana Sharma, Sumeet Gairola, R D Gaur, R M Painuli, T O Siddiqi
ETHNOPHARMACOLOGICAL RELEVANCE: Although many plants are claimed to possess anticonvulsant/antiepileptic (AC/AE) properties, but there is very little information available about plants used by various ethnic communities in different parts of India to treat epilepsy, one of the most common disorders of central nervous system (CNS); this communication provides significant ethnomedicinal information on the plants used by indigenous communities: Bhoxa, Tharu and nomadic Gujjars of sub-Himalayan region, Uttarakhand, India to treat epilepsy, so that it could be used as a baseline data for studying chemical constituents and biological activities of these promising plants...
October 28, 2013: Journal of Ethnopharmacology
Sophia Yui Kau Fong, Qiong Gao, Zhong Zuo
Background. Carbamazepine (CBZ) is a first-line antiepileptic drug which may be prone to drug interactions. Systematic review of herb- and food-drug interactions on CBZ is warranted to provide guidance for medical professionals when prescribing CBZ. Method. A systematic review was conducted on six English databases and four Chinese databases. Results. 196 out of 3179 articles fulfilled inclusion criteria, of which 74 articles were reviewed and 33 herbal products/dietary supplement/food interacting with CBZ were identified...
2013: Evidence-based Complementary and Alternative Medicine: ECAM
Mehri Abdollahi Fard, Asie Shojaii
Epilepsy is a brain disorder which affects about 50 million people worldwide. Ineffectiveness of the drugs in some cases and the serious side effects and chronic toxicity of the antiepileptic drugs lead to use of herbal medicine as a form of complementary and alternative medicine. In this review modern evidences for the efficacy of antiepileptic medicinal plants in Traditional Iranian Medicine (TIM) will be discussed. For this purpose electronic databases including PubMed, Scopus, Sciencedirect, and Google Scholar were searched for each of the antiepileptic plants during 1970-February 2013...
2013: BioMed Research International
Shun Takaku, Eiichi Osono, Hideki Kuribayashi, Chizuno Takaku, Naoki Hirama, Hidemi Takahashi
OBJECTIVE: Migraine is a common neurologic condition characterized by the disabling effects it has on the patient. Despite recent progress in drug development, better pharmacotherapies against migraine are still needed. This report describes an herbal medicine that has a strong pain-relieving effect against migraine. PATIENT: This case involved a 49-year-old woman with a 16-year history of headaches. Migraine without aura had been diagnosed at age 47 years. Despite taking antiepileptic drugs as prophylaxis, she had migraines almost three times a week, especially in the morning...
December 2013: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
James W Mitchell, Stefano Seri, Andrea E Cavanna
It is currently estimated that about 20%-30% of adults and 10%-40% of children diagnosed with epilepsy suffer from uncontrolled or poorly controlled seizures, despite optimal medical management. In addition to its huge economic costs, treatment-refractory epilepsy has a widespread impact on patients' health-related quality of life. The present paper focuses on the concepts of refractory and difficult-to-treat seizures and their pharmacological management. Evidence on efficacy and tolerability of rational pharmacotherapy with antiepileptic drug combinations and of non-pharmacological treatment options such as epilepsy surgery, neurostimulation, metabolic treatment and herbal remedies is reviewed...
2012: Journal of Central Nervous System Disease
P O Nwani, E O Arinzechi, A L Asomugha, K O Enwereji, M C Nwosu, A O Ogunniyi
BACKGROUND: Epilepsy, one of the world's most prevalent chronic diseases is still regarded as a supernatural disease in many parts of the world. These superstitious and cultural beliefs tend to influence treatment seeking behavior of people living with epilepsy (PWE) and their caregivers. STUDY DESIGN: People living with epilepsy in a semi-urban community in Southeast Nigeria were identified in a two phase door-to-door cross-sectional descriptive study. Those identified and their caregivers were further interviewed to determine their concepts of the disease, their treatment (actual and preferred) and what informed treatment...
January 2013: West African Journal of Medicine
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