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https://www.readbyqxmd.com/read/29138665/-epidemiological-profile-of-uropathogenic-enterobacteria-producing-extended-spectrum-beta-lactamases
#1
Mohammed Sbiti, Khalid Lahmadi, Lhoussaine Louzi
Urinary tract infections due to enterobacteria producing extended spectrum beta-lactamases (ESBL-E) constitute a infectious risk, a major therapeutic challenge and can even lead, in some cases, to a deadlock beacuse of their multi-resistance to antibiotics. This study aimed to determine the epidemiological profile of uropathogenic ESBL-E and to describe their current level of resistance to antibiotics for a better patient management according to local data. We conducted a retrospective study of all ESBL-E strains isolated from all cytobacteriogical testing of urine (CBEU) treated in the Microbiology Laboratory at the Military Hospital of Moulay Ismail, Meknes over a period of three years (from 1 January 2013 to 31 December 2015)...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/29118939/escherichia-coli-pathotypes-and-shigella-sero-groups-in-diarrheic-children-in-nairobi-city-kenya
#2
Peter Lokamar Nyanga, Jackson Onyuka, Mark Kilongosi Webale, Tom Were, Valentine Budambula
Aim: In the present study, we investigated the prevalence of E. coli pathotypes and Shigella sero-groups and their antimicrobial profiles among diarrheic children in Nairobi city, Kenya. Background: Although diarrheagenic E. coli pathotypes and Shigella sero-groups are leading causes of diarrhea in children under five years in developing countries, their distribution and antimicrobial resistance vary from place to place and over time in a given region. Methods: In a cross-sectional study, we enrolled diarrheic children (n=354) under five years seeking treatment at Mbagathi Hospital, Nairobi city, Kenya,...
2017: Gastroenterology and Hepatology From Bed to Bench
https://www.readbyqxmd.com/read/29113746/quinoline-derivatives-bearing-pyrazole-moiety-synthesis-and-biological-evaluation-as-possible-antibacterial-and-antifungal-agents
#3
Mohamed F El Shehry, Mostafa M Ghorab, Samir Y Abbas, Eman A Fayed, Said A Shedid, Yousry A Ammar
In an attempt for development of new antimicrobial agents, three series of quinoline derivatives bearing pyrazole moiety have been synthesized. The first series was synthesized through the synthesis of 4-(quinolin-2-yloxy)benzaldehyde and 4-(quinolin-2-yloxy)acetophenone and then treatment with ketone or aldehyde derivatives to afford the corresponding chalcones. Cyclization of the latter chalcones with hydrazine derivatives led to the formation of new pyrazoline derivatives. The second series was synthesized via the synthesis of 2-hydrazinylquinoline and then treatment with formylpyrazoles to afford the corresponding hydrazonyl pyrazole derivatives...
October 19, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29112171/antimicrobial-abietane-type-diterpenoids-from-plectranthus-punctatus
#4
Negera Abdissa, Marcel Frese, Norbert Sewald
Four new para-benzoquinone containing abietane-type diterpenoids (1-4) along with thirteen known diterpenoids (5-17) were isolated from the roots of Plectranthus punctatus. The structures of the compounds were established by detailed spectroscopic analyses and comparison with literature data. The compounds were tested for their antibacterial and cytotoxic activity and showed significant inhibitory activity against all bacterial strains used, with compounds 6, 8, 10, and 11 showing an inhibition zone for Staphylococcus warneri even greater than the reference drug, gentamycin...
November 7, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29102933/mesenchymal-stem-cells-contribute-to-improvement-of-renal-function-in-a-canine-kidney-injury-model
#5
Seung-Jun Lee, Min-Ok Ryu, Min-Soo Seo, Sang-Bum Park, Jin-Ok Ahn, Sei-Myoung Han, Kyung-Sun Kang, Dong-Ha Bhang, Hwa-Young Youn
BACKGROUND/AIM: The kidney excretes waste materials and regulates important metabolic functions, and renal disorders constitute a significant medical problem and can result in fatalities. In the present study, mesenchymal stem cells derived from canine umbilical cord blood (cUCB-MSCs) were isolated and evaluated for their ability to improve renal function in a canine model of acute kidney injury (AKI). MATERIALS AND METHODS: The canine AKI model was developed by i...
November 2017: In Vivo
https://www.readbyqxmd.com/read/29098998/the-emergence-of-multidrug-resistant-pseudomonas-aeruginosa-in-cystic-fibrosis-patients-on-inhaled-antibiotics
#6
Atqah AbdulWahab, Khalid Zahraldin, Mazen A Sid Ahmed, Sulieman Abu Jarir, Mohammed Muneer, Shehab F Mohamed, Jemal M Hamid, Abubaker A I Hassan, Emad Bashir Ibrahim
INTRODUCTION: Multidrug-resistant Pseudomonas aeruginosa (MDR-PA) is an important and growing issue in the care of patients with cystic fibrosis (CF), and a major cause of morbidity and mortality. OBJECTIVE: The objective of the study was to describe the frequency of MDR-PA recovered from the lower respiratory samples of pediatric and adult CF patients, and its antibiotic resistance pattern to commonly used antimicrobial agents including β-lactams, aminoglycosides, and fluoroquinolones...
November 2017: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/29090447/adaptation-in-toxic-environments-comparative-genomics-of-loci-carrying-antibiotic-resistance-genes-derived-from-acid-mine-drainage-waters
#7
Florence Arsène-Ploetze, Olfa Chiboub, Didier Lièvremont, Julien Farasin, Kelle C Freel, Stephanie Fouteau, Valérie Barbe
Several studies have suggested the existence of a close relationship between antibiotic-resistant phenotypes and resistance to other toxic compounds such as heavy metals, which involve co-resistance or cross-resistance mechanisms. A metagenomic library was previously constructed in Escherichia coli with DNA extracted from the bacterial community inhabiting an acid mine drainage (AMD) site highly contaminated with heavy metals. Here, we conducted a search for genes involved in antibiotic resistance using this previously constructed library...
October 31, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29065922/persisting-demand-and-supply-gap-for-maternal-and-newborn-care-in-eastern-uganda-a-mixed-method-cross-sectional-study
#8
Rornald Muhumuza Kananura, Suzanne Namusoke Kiwanuka, Elizabeth Ekirapa-Kiracho, Peter Waiswa
BACKGROUND: The slow progress in reducing maternal and newborn death in low and middle-income countries is attributed to both demand and supply-side factors. This study assessed the changes in maternal and newborn services in health facilities as well as demand for maternal and newborn health services in Eastern Uganda. METHODS: The health assessment data were collected in August 2013 and September 2015 in the districts of Kamuli, Pallisa, and Kibuku. We purposively collected data on the availability of services from 40 health facilities that provided maternal and newborn services...
October 24, 2017: Reproductive Health
https://www.readbyqxmd.com/read/29062203/characterization-and-zoonotic-impact-of-shiga-toxin-producing-escherichia-coli-in-some-wild-bird-species
#9
Hanaa Mohamed Fadel, Rabab Afifi, Dheyazan Mohammed Al-Qabili
AIM: Wild birds are considered silent vectors of some zoonotic water and food borne pathogens of public health significance. Owing to the importance of Shiga toxin producing Escherichia coli (STEC) as the most pathogenic among the emerging diarrheagenic E. coli groups that can infect man; the present study was designed to detect the occurrence of STEC among wild birds in Egypt. MATERIALS AND METHODS: A total of 177 intestinal content swab samples originating from five wild bird species were investigated for the presence of E...
September 2017: Veterinary World
https://www.readbyqxmd.com/read/29055204/influence-of-bizerte-city-wastewater-treatment-plant-wwtp-on-abundance-and-antibioresistance-of-culturable-heterotrophic-and-fecal-indicator-bacteria-of-bizerte-lagoon-tunisia
#10
Mariem Souissi, Rached Laabidi, Patricia Aissa, Olivier Pringault, Olfa Ben Said
The waste water treatment plant (WWTP) of the city of Bizerte concentrates different types of chemical and biological pollutants in the Bizerte lagoon (Tunisia). Considering four upstream and downstream WWTP discharge stations, seventy nine, culturable bacterial strains were isolated and identified from water and sediment as fecal coliforms, fecal streptococci, pathogenic staphylococci and non-enterobacteriacea. Fecal coliforms were most abundant (2.5 10(5) bacteria/mg) in sediment of WWTP discharge. Leuconostoc spp (23...
October 18, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29023067/studies-on-staphylococcus-aureus-isolated-from-pimples
#11
Ajayi Adesola Adetutu, Bibi Oritsewehinmi, Oniha Margaret Ikhiwili, Atolagbe Oluwabunmi Moradeke, Anosike Selina Odochi, Onibokun Elizabeth Adeola
BACKGROUND AND OBJECTIVE: Pimples (acne) are small skin lesions or inflammations of the skin. The most common factor causing acne is the hormonal changes that occur during adolescent and teenage years. Antibiotics are becoming less effective in the treatment of pimples due to increasing concerns of antibiotic resistance. This study was therefore carried out to characterize the isolates from the pimples of Covenant University Students and to determine their antibiotics sensitivity pattern...
2017: Pakistan Journal of Biological Sciences: PJBS
https://www.readbyqxmd.com/read/29016581/bacteriological-study-of-otitis-media-and-its-antibiotic-susceptibility-pattern
#12
Rabina Basnet, Sudarshan Sharma, Jid Chani Rana, Pradeep Kumar Shah
BACKGROUND: Otitis Media is a prevailing and notorious infection in developing countries causing serious local damage and threating complication. Mainly in developing countries like Nepal, Otitis Media results because of illiteracy, poverty and poor hygiene. The aim of this study was to determine the profile of Otitis Media, its causative agents and their antibiotic susceptibility pattern. METHODS: The study included 263 pus samples from 240 patients attending ENT department of Bharatpur hospital from May 2015 to January 2016...
September 8, 2017: Journal of Nepal Health Research Council
https://www.readbyqxmd.com/read/28979879/localized-lipodystrophy-following-single-dose-intramuscular-gentamycin-injection
#13
Indar K Sharawat, Lesa Dawman
No abstract text is available yet for this article.
September 2017: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/28969155/linezolid-and-vancomycin-resistant-enterococci-a-therapeutic-problem
#14
Garima Yadav, Bhaskar Thakuria, Molly Madan, Vivek Agwan, Anita Pandey
INTRODUCTION: Enterococci are recognized as opportunistic pathogens, as well as commensals in both humans and animals. They are an important cause of nosocomial infections, difficult to treat, as the organism have intrinsic and acquired resistance to many antibiotics. AIM: To isolate and identify clinically relevant Enterococcus up to species level from all the clinical samples processed in the microbiology laboratory and also to study their resistance pattern. MATERIALS AND METHODS: A prospective study was carried out for a period of one year from May 2014 to April 2015 at the Department of Microbiology, Subharti Medical College, Meerut, Uttar Pradesh, India...
August 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28955644/effects-of-debaryomyces-hansenii-treatment-on-intestinal-microorganisms-in-mice-with-antibiotics-induced-diarrhea
#15
Lu He, Chengxing Long, Youjia Liu, Yanfang Guo, Nenqun Xiao, Zhoujin Tan
To investigate the influence of Debaryomyces hansenii treatment on intestinal microorganisms in mice with antibiotics-induced diarrhea, mouse model of antibiotics-induced diarrhea was created by gavaging mice with mixed antibiotics (23.33 mL/kg/days) composed of gentamycin sulfate and cefradine for 5 days. Mice with the symptom of diarrhea were then treated with D. hansenii by intragastric administration. The control group mice were given with sterile water. After 4 day treatment, total DNA of intestinal microflora of treated and control mice was extracted, and their quantities were measured by sequencing the V4 region of 16S rDNA...
October 2017: 3 Biotech
https://www.readbyqxmd.com/read/28914802/phylogenetic-analysis-and-antimicrobial-profiles-of-cultured-emerging-opportunistic-pathogens-phyla-actinobacteria-and-proteobacteria-identified-in-hot-springs
#16
Jocelyn Leonie Jardine, Akebe Luther King Abia, Vuyo Mavumengwana, Eunice Ubomba-Jaswa
Hot spring water may harbour emerging waterborne opportunistic pathogens that can cause infections in humans. We have investigated the diversity and antimicrobial resistance of culturable emerging and opportunistic bacterial pathogens, in water and sediment of hot springs located in Limpopo, South Africa. Aerobic bacteria were cultured and identified using 16S ribosomal DNA (rDNA) gene sequencing. The presence of Legionella spp. was investigated using real-time polymerase chain reaction. Isolates were tested for resistance to ten antibiotics representing six different classes: β-lactam (carbenicillin), aminoglycosides (gentamycin, kanamycin, streptomycin), tetracycline, amphenicols (chloramphenicol, ceftriaxone), sulphonamides (co-trimoxazole) and quinolones (nalidixic acid, norfloxacin)...
September 15, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28903168/-sharing-bacterial-microbiota-between-owners-and-their-pets-dogs-cats
#17
Jan Wipler, Zuzana Čermáková, Tomáš Hanzálek, Hana Horáková, Helena Žemličková
INTRODUCTION: The microbiological aspect of a relationship between pets (dogs/cats) and their owners is mainly concerned with the incidence of shared bacterial species, in particular potential pathogens. Given the great popularity of sharing homes with pets (dogs/cats) in the Czech Republic, there is an increased possibility of communication between microbiota of the two macroorganisms (pet and owner). The aim of the study was to determine the biodiversity of shared bacteria and possibility of exchange of genes of resistance to antimicrobial agents between potential pathogens based on the close relationship between pets and humans...
June 2017: Klinická Mikrobiologie a Infekc̆ní Lékar̆ství
https://www.readbyqxmd.com/read/28870347/in%C3%A2-vitro-inhibitory-analysis-of-consensus-sirnas-against-ns3-gene-of-hepatitis-c-virus-1a-genotype
#18
Imran Shahid, Waleed Hassan AlMalki, Mohammed Wanees AlRabia, Mohammed Hasan Mukhtar, Shaia Saleh R Almalki, Saad Ahmed Alkahtani, Sami S Ashgar, Hani S Faidah, Muhammad Hassan Hafeez
OBJECTIVE: To explore inhibitory effects of genome-specific, chemically synthesized siRNAs (small interference RNA) against NS3 gene of hepatitis C virus (HCV) 1a genotype in stable Huh-7 (human hepatoma) cells as well as against viral replication in serum-inoculated Huh-7 cells. METHODS: Stable Huh-7 cells persistently expressing NS3 gene were produced under antibiotic gentamycin (G418) selection. The cell clones resistant to 1000 μg antibiotic concentration (G418) were picked as stable cell clones...
July 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/28862669/antimicrobial-susceptibility-of-staphylococcus-aureus-isolated-from-recreational-waters-and-beach-sand-in-eastern-cape-province-of-south-africa
#19
Olufemi Emmanuel Akanbi, Henry Akum Njom, Justine Fri, Anthony C Otigbu, Anna M Clarke
Background: Resistance of Staphylococcus aureus to commonly used antibiotics is linked to their ability to acquire and disseminate antimicrobial-resistant determinants in nature, and the marine environment may serve as a reservoir for antibiotic-resistant bacteria. This study determined the antibiotic sensitivity profile of S.aureus isolated from selected beach water and intertidal beach sand in the Eastern Cape Province of South Africa. Methods: Two hundred and forty-nine beach sand and water samples were obtained from 10 beaches from April 2015 to April 2016...
September 1, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28831221/prevalence-and-antimicrobial-resistance-pattern-of-shiga-toxigenic-escherichia-coli-in-diarrheic-buffalo-calves
#20
M Srivani, Y Narasimha Reddy, K V Subramanyam, M Ramakoti Reddy, T Srinivasa Rao
AIM: Aim of the study was to investigate the prevalence, virulence gene profiles, and antimicrobial resistance pattern of Shiga toxigenic Escherichia coli (STEC) in diarrheic buffalo calves from Andhra Pradesh and Telangana States. MATERIALS AND METHODS: A total of 375 fecal samples from diarrheic buffalo calves of 1-7, 8-30, 31-60, and 61-90 days age were collected from which STEC were isolated, and virulence genes were detected using multiplex polymerase chain reaction...
July 2017: Veterinary World
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