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https://www.readbyqxmd.com/read/29317719/application-of-rotating-magnetic-fields-increase-the-activity-of-antimicrobials-against-wound-biofilm-pathogens
#1
A F Junka, R Rakoczy, P Szymczyk, M Bartoszewicz, P P Sedghizadeh, K Fijałkowski
Infective complications are a major factor contributing to wound chronicity and can be associated with significant morbidity or mortality. Wound bacteria are protected in biofilm communities and are highly resistant to immune system components and to antimicrobials used in wound therapy. There is an urgent medical need to more effectively eradicate wound biofilm pathogens. In the present work, we tested the impact of such commonly used antibiotics and antiseptics as gentamycin, ciprofloxacin, octenidine, chlorhexidine, polihexanidine, and ethacridine lactate delivered to Staphylococcus aureus and Pseudomonas aeruginosa biofilms in the presence of rotating magnetic fields (RMFs) of 10-50 Hz frequency and produced by a customized RMF generator...
January 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29301391/locacorten-vioform-ototoxicity-upon-guinea-pig-middle-ear-application
#2
Owen Woods, Issam Saliba
Background and Objectives: Locacorten Vioform (Novartis UK) is frequently prescribed for otomycosis. Its component, Clioquinol, also has anti-bacterial properties. Up to this point, its ototoxic potential has not been evaluated. Our objective aims to evaluate Locacorten Vioform's potential ototoxicity when applied directly to the middle ear cavity. Materials and Methods: We performed an experimental prospective animal study in our animal research center with 20 Hartley guinea pigs divided into 2 groups...
January 5, 2018: Journal of Audiology & Otology
https://www.readbyqxmd.com/read/29258622/nasal-colonization-and-antimicrobial-susceptibility-pattern-of-staphylococcus-aureus-among-pre-school-children-in-ethiopia
#3
Alemayehu Reta, Moges Wubie, Getnet Mekuria
BACKGROUND: Staphylococcus aureus is one of the bacterium that can asymptomatically colonize the human upper respiratory tract (i.e. nose and throat). Carriage of S. aureus, including methicillin resistant S. aureus, is common to children. The aim at this study was to determine the nasal colonization, associated factors and antimicrobial susceptibility patterns of S. aureus isolates among pre-school children in Debre Markos town. METHODS: Institutional-based cross sectional study was conducted...
December 19, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/29248233/lactobacillus-casei-asp23-gene-contributes-to-gentamycin-resistance-via-regulating-specific-membrane-associated-proteins
#4
Wenyi Zhang, Chenxia Cao, Jie Zhang, Lai-Yu Kwok, Heping Zhang, Yongfu Chen
Lactobacillus casei Zhang is a probiotic strain originally isolated from koumiss. Previously, we showed that an alkaline shock protein (encoded by asp23) was involved in the adaptation of L. casei Zhang to gentamycin. In the present study, we compared the proteomes of the asp23 mutant and its parent strain grown in the presence of gentamycin. The results showed that 22 and 21 proteins were significantly up- and downregulated, respectively (>1.5-fold difference). By parallel reaction monitoring analysis, we further validated that specific membrane-associated proteins were important in regulating the antibiotics-induced cell wall stress...
December 13, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/29242764/diversity-of-intestinal-bacterial-lactase-gene-in-antibiotics-induced-diarrhea-mice-treated-with-chinese-herbs-compound-qi-wei-bai-zhu-san
#5
Lu He, Yawei Liu, Yanfang Guo, Kejia Shen, Huaying Hui, Zhoujin Tan
The current investigation is trying to study the impact of the mixture of Chinese herbs Qi Wei Bai Zhu San (QWBZS) on bacterial lactase gene from antibiotics-induced diarrhea (AAD) mice, as the good curative effect of QWBZS on diarrhea. Mice (6 mice per group) were randomly selected as control, model and treatment groups. To induce diarrhea, mice in both model and treatment groups were intragastrically injected with mixture of gentamycin sulfate and cefradine (23.33 mL kg-1 day-1) twice per day and continuously for totally 5 days...
January 2018: 3 Biotech
https://www.readbyqxmd.com/read/29231915/lactobacillus-gasseri-endocarditis-on-the-aortic-valve-bioprosthesis-a-case-report
#6
Waldemar Elikowski, Małgorzata Małek-Elikowska, Monika Lisiecka, Anna Bodora, Katarzyna Wiśniewska, Zofia Oko-Sarnowska
Lactobacillus is a genus of Gram-positive, facultative anaerobic/ microaerophilic, rod-shaped bacteria. Lactobacilli constitute a significant component of the human microbiota in the oral cavity, gastrointestinal tract and female urogenital tract. They are also widely used as probiotics. Rarely, especially in patients with impaired immunity or with structural heart disease, do Lactobacilli become the pathogen responsible for serious infections, e.g. infective endocarditis (IE). CASE REPORT: The authors describe a case of an 80-year-old female with a past history of aortic valve replacement, mitral annuloplasty and pacemaker implantation admitted to hospital due to weakening, subfebrile state and chills...
November 23, 2017: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29230393/commentary-hernia-mesh-and-topical-antibiotics-especially-gentamycin-seeking-the-evidence-for-the-perfect-outcome%C3%A2
#7
COMMENT
Ekaterini Christina Tampaki, Athanasios Tampakis, Konstantinos Kontzoglou, Gregory Kouraklis
No abstract text is available yet for this article.
2017: Frontiers in Surgery
https://www.readbyqxmd.com/read/29218040/adaptation-of-lactobacillus-casei-zhang-to-gentamycin-involves-an-alkaline-shock-protein
#8
Wenyi Zhang, Huiling Guo, Chenxia Cao, Lina Li, Lai-Yu Kwok, Heping Zhang, Zhihong Sun
Lactobacillus (L. casei) Zhang is a koumiss-originated probiotic strain, which was used as a model in a long-term antibiotics-driven evolution experiment to reveal bacterial evolutionary dynamics; and we isolated gentamycin-resistant L. casei Zhang descendents. To decipher the gentamycin resistance mechanism, here we cultivated the parental L. casei Zhang and its descendent cells in an antibiotics-containing environment to compare their global protein expression profiles using the iTRAQ-based proteomic approach...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29204285/molecular-characterization-of-acinetobacter-baumannii-isolated-from-iraqi-hospital-environment
#9
I M S Al-Kadmy, A N M Ali, I M A Salman, S S Khazaal
Healthcare-associated items are a common source of acquired infections, and hospital-acquired infections cause significant mortality and morbidity worldwide. Acinetobacter baumannii is the most prevalent infection-causing organism in the hospital environment. Hospital articles and objects are the main sources of infection with the ability to transmit some of the pathogenic microorganisms such as A. baumannii, which is considered a serious problem in therapeutic treatments. In the current study, we isolated A...
January 2018: New Microbes and New Infections
https://www.readbyqxmd.com/read/29204221/antibiotic-resistance-patterns-and-virulence-determinants-of-different-sccmec-and-pulsotypes-of-staphylococcus-aureus-isolated-from-a-major-hospital-in-ilam-iran
#10
REVIEW
Mehdi Abbasi, Majid BaseriSalehi, Nima Bahador, Morovat Taherikalani
Aims & Objectives: The aim of this study is to evaluate genetic relatedness, antibiotic resistance pattern, and virulence characteristics of different types of S. aureus isolated from air, surfaces, staff, and patients in a Public hospital in Ilam. Methods & Materials: A total of 88 of 140 staphylococci identified as S. aureus by conventional and molecular methods were used in this study. Isolate samples were obtained from surfaces, staff, patients, and hospital indoor air...
2017: Open Microbiology Journal
https://www.readbyqxmd.com/read/29169012/methicillin-resistant-staphylococcus-aureus-isolated-from-an-intensive-care-unit-in-minas-gerais-brazil-over-a-six-year-period
#11
Thiago C Nascimento, Cláudio G Diniz, Vânia L Silva, Alessandra B Ferreira-Machado, Marina O Fajardo, Tamara Lopes R de Oliveira, Dennis de C Ferreira, Fernanda S Cavalcante, Kátia R Netto Dos Santos
To characterize methicillin-resistant Staphylococcus aureus (MRSA) isolates from an intensive care unit of a tertiary-care teaching hospital, between 2005 and 2010. A total of 45 MRSA isolates were recovered from patients admitted to the ICU in the study period. Resistance rates higher than 80% were found for clindamycin (100%), erythromycin (100%), levofloxacin (100%), azithromycin (97.7%), rifampin (88.8%), and gentamycin (86.6%). The SCCmec typing revealed that the isolates harbored the types III (66.7%), II (17...
November 20, 2017: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29164140/phenotypic-and-genotypic-features-of-a-salmonella-heidelberg-strain-isolated-in-broilers-in-brazil-and-their-possible-association-to-antibiotics-and-short-chain-organic-acids-resistance-and-susceptibility
#12
Elizabeth Santin, Ricardo Mitsuo Hayashi, Jessica Caroline Wammes, Ricardo Gonzalez-Esquerra, Marcelo Falsarella Carazzolle, Caio César de Melo Freire, Paulo Sérgio Monzani, Anderson Ferreira da Cunha
Salmonella enterica serovar Heidelberg is a human pathogen also found in broilers. A strain (UFPR1) has been associated with field reports of resistance to short-chain organic acids (SCOA) in broilers in the South of Brazil, but was susceptible to a Bacillus subtilis-based probiotic added in feed in a related study. This work aimed to (i) report clinical symptoms caused by SH UFPR1 in broilers, (ii) study its susceptibility to some antibiotics in vitro, and (iii) SCOA in vivo; and (iv) relate these phenotypic observations with its genome characteristics...
2017: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/29138665/-epidemiological-profile-of-uropathogenic-enterobacteria-producing-extended-spectrum-beta-lactamases
#13
Mohammed Sbiti, Khalid Lahmadi, Lhoussaine Louzi
Urinary tract infections due to enterobacteria producing extended spectrum beta-lactamases (ESBL-E) constitute a infectious risk, a major therapeutic challenge and can even lead, in some cases, to a deadlock beacuse of their multi-resistance to antibiotics. This study aimed to determine the epidemiological profile of uropathogenic ESBL-E and to describe their current level of resistance to antibiotics for a better patient management according to local data. We conducted a retrospective study of all ESBL-E strains isolated from all cytobacteriogical testing of urine (CBEU) treated in the Microbiology Laboratory at the Military Hospital of Moulay Ismail, Meknes over a period of three years (from 1 January 2013 to 31 December 2015)...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/29118939/escherichia-coli-pathotypes-and-shigella-sero-groups-in-diarrheic-children-in-nairobi-city-kenya
#14
Peter Lokamar Nyanga, Jackson Onyuka, Mark Kilongosi Webale, Tom Were, Valentine Budambula
Aim: In the present study, we investigated the prevalence of E. coli pathotypes and Shigella sero-groups and their antimicrobial profiles among diarrheic children in Nairobi city, Kenya. Background: Although diarrheagenic E. coli pathotypes and Shigella sero-groups are leading causes of diarrhea in children under five years in developing countries, their distribution and antimicrobial resistance vary from place to place and over time in a given region. Methods: In a cross-sectional study, we enrolled diarrheic children (n=354) under five years seeking treatment at Mbagathi Hospital, Nairobi city, Kenya,...
2017: Gastroenterology and Hepatology From Bed to Bench
https://www.readbyqxmd.com/read/29113746/quinoline-derivatives-bearing-pyrazole-moiety-synthesis-and-biological-evaluation-as-possible-antibacterial-and-antifungal-agents
#15
Mohamed F El Shehry, Mostafa M Ghorab, Samir Y Abbas, Eman A Fayed, Said A Shedid, Yousry A Ammar
In an attempt for development of new antimicrobial agents, three series of quinoline derivatives bearing pyrazole moiety have been synthesized. The first series was synthesized through the synthesis of 4-(quinolin-2-yloxy)benzaldehyde and 4-(quinolin-2-yloxy)acetophenone and then treatment with ketone or aldehyde derivatives to afford the corresponding chalcones. Cyclization of the latter chalcones with hydrazine derivatives led to the formation of new pyrazoline derivatives. The second series was synthesized via the synthesis of 2-hydrazinylquinoline and then treatment with formylpyrazoles to afford the corresponding hydrazonyl pyrazole derivatives...
October 19, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29112171/antimicrobial-abietane-type-diterpenoids-from-plectranthus-punctatus
#16
Negera Abdissa, Marcel Frese, Norbert Sewald
Four new para-benzoquinone containing abietane-type diterpenoids (1-4) along with thirteen known diterpenoids (5-17) were isolated from the roots of Plectranthus punctatus. The structures of the compounds were established by detailed spectroscopic analyses and comparison with literature data. The compounds were tested for their antibacterial and cytotoxic activity and showed significant inhibitory activity against all bacterial strains used, with compounds 6, 8, 10, and 11 showing an inhibition zone for Staphylococcus warneri even greater than the reference drug, gentamycin...
November 7, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29102933/mesenchymal-stem-cells-contribute-to-improvement-of-renal-function-in-a-canine-kidney-injury-model
#17
Seung-Jun Lee, Min-Ok Ryu, Min-Soo Seo, Sang-Bum Park, Jin-Ok Ahn, Sei-Myoung Han, Kyung-Sun Kang, Dong-Ha Bhang, Hwa-Young Youn
BACKGROUND/AIM: The kidney excretes waste materials and regulates important metabolic functions, and renal disorders constitute a significant medical problem and can result in fatalities. In the present study, mesenchymal stem cells derived from canine umbilical cord blood (cUCB-MSCs) were isolated and evaluated for their ability to improve renal function in a canine model of acute kidney injury (AKI). MATERIALS AND METHODS: The canine AKI model was developed by i...
November 2017: In Vivo
https://www.readbyqxmd.com/read/29098998/the-emergence-of-multidrug-resistant-pseudomonas-aeruginosa-in-cystic-fibrosis-patients-on-inhaled-antibiotics
#18
Atqah AbdulWahab, Khalid Zahraldin, Mazen A Sid Ahmed, Sulieman Abu Jarir, Mohammed Muneer, Shehab F Mohamed, Jemal M Hamid, Abubaker A I Hassan, Emad Bashir Ibrahim
INTRODUCTION: Multidrug-resistant Pseudomonas aeruginosa (MDR-PA) is an important and growing issue in the care of patients with cystic fibrosis (CF), and a major cause of morbidity and mortality. OBJECTIVE: The objective of the study was to describe the frequency of MDR-PA recovered from the lower respiratory samples of pediatric and adult CF patients, and its antibiotic resistance pattern to commonly used antimicrobial agents including β-lactams, aminoglycosides, and fluoroquinolones...
November 2017: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/29090447/adaptation-in-toxic-environments-comparative-genomics-of-loci-carrying-antibiotic-resistance-genes-derived-from-acid-mine-drainage-waters
#19
Florence Arsène-Ploetze, Olfa Chiboub, Didier Lièvremont, Julien Farasin, Kelle C Freel, Stephanie Fouteau, Valérie Barbe
Several studies have suggested the existence of a close relationship between antibiotic-resistant phenotypes and resistance to other toxic compounds such as heavy metals, which involve co-resistance or cross-resistance mechanisms. A metagenomic library was previously constructed in Escherichia coli with DNA extracted from the bacterial community inhabiting an acid mine drainage (AMD) site highly contaminated with heavy metals. Here, we conducted a search for genes involved in antibiotic resistance using this previously constructed library...
October 31, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29065922/persisting-demand-and-supply-gap-for-maternal-and-newborn-care-in-eastern-uganda-a-mixed-method-cross-sectional-study
#20
Rornald Muhumuza Kananura, Suzanne Namusoke Kiwanuka, Elizabeth Ekirapa-Kiracho, Peter Waiswa
BACKGROUND: The slow progress in reducing maternal and newborn death in low and middle-income countries is attributed to both demand and supply-side factors. This study assessed the changes in maternal and newborn services in health facilities as well as demand for maternal and newborn health services in Eastern Uganda. METHODS: The health assessment data were collected in August 2013 and September 2015 in the districts of Kamuli, Pallisa, and Kibuku. We purposively collected data on the availability of services from 40 health facilities that provided maternal and newborn services...
October 24, 2017: Reproductive Health
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