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Chuanjun Zhuo, Xubin Li, Hongqing Zhuang, Shunli Tian, Hailong Cui, Ronghuan Jiang, Chuanxin Liu, Ran Tao, Xiaodong Lin
Various intravesical therapies have been introduced into clinical practices for controlling non-muscle invasive bladder cancer (NMIBC). However, evidence with respect to the efficacy and safety of those intravesical therapies is very limited. Hence, we present a network meta-analysis in order to address this limitation in the current literature. The primary outcomes were the risk of tumor recurrence (TR), tumor progression (TP) and disease-specific mortality (DM). Secondary outcomes included the risk of fever, cystitis and haematuria...
December 13, 2016: Oncotarget
Han-Yu Deng, Wen-Ping Wang, Yi-Dan Lin, Long-Qi Chen
A best evidence topic in cardiothoracic surgery was written according to a structured protocol. The question addressed was 'Can mitomycin facilitate endoscopic dilatation treatment of benign esophageal stricture (mainly including caustic and anastomotic esophageal stricture)?' Altogether, 115 papers were found using the reported search, of which 6 represented the best evidence to answer the clinical question, which included 1 randomized controlled trial, 1 systematic review and 4 cohort studies. The authors, journal, date and country of publication, patient group studied, study type, relevant outcomes and results of these papers are tabulated...
January 2017: Interactive Cardiovascular and Thoracic Surgery
Sara Di Santo, Marianna Trignani, Matteo Neri, Angelo Milano, Paolo Innocenti, Maria Taraborrelli, Antonietta Augurio, Annamaria Vinciguerra, Monica Di Tommaso, Lucia Anna Ursini, Angelo Di Pilla, Marta Di Nicola, Domenico Genovesi
AIM: Main endpoint was a response rate to therapy; secondary endpoints were disease-free survival, overall survival, acute and late toxicities, specially in terms of anorectal and urinary continence. BACKGROUND: Radiochemotherapy for anal cancer achieves a good clinical response, locoregional control, anal function preservation. However, oncologic outcomes can differ using radiotherapy plus fluorouracil and mytomicin vs. cisplatin and fluorouracil. METHODS: Between 2000 and 2012, 27 anal cancer patients receiving radiotherapy combined with two different radiochemotherapy schedules, fluorouracil and mytomicin (group A) and cisplatin plus fluorouracil (group B)...
March 2015: Reports of Practical Oncology and Radiotherapy
Yoshie Yamaguchi, Dawei Deng, Yoshinori Sato, Yung-Te Hou, Rie Watanabe, Kohei Sasaki, Masaaki Kawabe, Eiichi Hirano, Tetsuo Morinaga
BACKGROUND: Three-dimensional (3D) in vitro cultures can recapitulate the physiological in vivo microenvironment. 3D Modeling techniques have been investigated and applied in anticancer drug screening. MATERIALS AND METHODS: A silicate fiber scaffold was used for 3D cell cultures, and used to model the efficacy of anticancer drugs, such as mytomicin C and doxorubicin. RESULTS: A unique 3D structure was observed in 13 human tumor cell lines on scaffold, and these cells exhibited higher drug resistance than cells in two-dimensional (2D) cultures...
December 2013: Anticancer Research
Alessandro Bittoni, Mario Scartozzi, Riccardo Giampieri, Luca Faloppi, Maristella Bianconi, Alessandra Mandolesi, Michela Del Prete, Mirco Pistelli, Luca Cecchini, Italo Bearzi, Stefano Cascinu
BACKGROUND: Recently, a new classification for gastric cancer (GC) has been proposed, based on Lauren's histology and on anatomic tumour location, identifying three subtypes of disease: type 1 (proximal non diffuse GC), type 2 (diffuse GC) and type 3 (distal non diffuse GC). Aim of our analysis was to compare clinical outcome according to different GC subtypes (1,2,3) in metastatic GC patients receiving first-line chemotherapy. PATIENTS AND METHODS: Advanced GC pts treated with a first-line combination chemotherapy were included in our analysis...
2013: PloS One
M Robella, M Vaira, P Marsanic, A Mellano, A Cinquegrana, A Sottile, M De Simone
AIM: Pseudomyxoma peritonei (PMP) is a rare form of peritoneal carcinomatosis characterized by abnormal quantity of extracellular mucinous material. It almost originates from a primary appendiceal tumor with different malignancy degrees. The purpose of this study was to evaluate outcome and long-term survival on 80 patients affected by PMP after cytoreductive surgery (CRS) associated with hyperthermic intraperitoneal chemotherapy (HIPEC). METHODS: From October 1995 to June 2012, about 550 operations for PC were performed; in 300 cases surgical cytoreduction in association with HIPEC was carried out...
December 2013: Minerva Chirurgica
Luigina Graziosi, Francesco Cantarella, Elvira Mingrone, Marco Gunnellini, Emanuel Cavazzoni, Marina Liberati, Annibale Donini
BACKGROUND: The prognosis of locally advanced Gastric Cancer following surgical therapy alone is poor. Peritoneum represents a preferential site of dissemination in such neoplasm. Hyperthermic intraperitoneal chemotherapy (HIPEC) has been used in association with cytoreductive surgery (CRS) in the treatment of GC peritoneal carcinomatosis (PC). Aim of our preliminary experience is reporting our data on prophylactic HIPEC (P-HIPEC) in patients with GC at high risk of developing PC. METHODS: Eleven patients underwent P-HIPEC at our General and Emergency Surgery Department...
September 2013: Annali Italiani di Chirurgia
Aline M Prieto, André G dos Santos, Ana Paula S Oliveira, Alberto J Cavalheiro, Dulce H S Silva, Vanderlan S Bolzani, Eliana Ap Varanda, Christiane P Soares
Studies have shown that Casearia sylvestris compounds protect DNA from damage both in vitro and in vivo. Complementarily, the aim of the present study was to assess the chemopreventive effect of casearin B (CASB) against DNA damage using the Ames test, the comet assay and the DCFDA antioxidant assay. The genotoxicity was assessed by the comet assay in HepG2 cells. CASB was genotoxic at concentrations higher than 0.30 μM when incubated with the FPG (formamidopyrimidine-DNA glycosylase) enzyme. For the antigenotoxicity comet assay, CASB protected the DNA from damage caused by H(2)O(2) in the HepG2 cell line in concentrations above 0...
March 2013: Food and Chemical Toxicology
Wilson L Costa, Felipe J F Coimbra, Héber S C Ribeiro, Alessandro L Diniz, André Luís de Godoy, Mariadirleifs Begnami, Milton J B Silva, Marcelo F Fanelli, Celso A L Mello
BACKGROUND: Gastric cancer relapse occurs in about 30% of the patients treated with gastrectomy and D2-lymphadenectomy, mainly as distant or peritoneal metastases. Hyperthermic intraperitoneal chemotherapy (HIPEC) has been associated with an improvement in survival and lower peritoneal recurrence, albeit with increased morbidity. The aim of this study is to report the preliminary results of the association of perioperative chemotherapy, radical surgery and HIPEC in high-risk gastric patients in a single institution...
2012: World Journal of Surgical Oncology
Seulkee Park, Yanghee Woo, Hogeun Kim, Yong Chan Lee, Sungho Choi, Woo Jin Hyung, Sung Hoon Noh
PURPOSE: The purpose of this study was to investigate the reliability and the clinical applicability of the adenosine-triphosphate-based chemotherapy response assay (ATP-CRA) as a method of determining in vitro chemosensitivity in patients with gastric cancer. MATERIALS AND METHODS: A total of 243 gastric cancer tissue samples were obtained from gastrectomies performed between February 2007 and January 2010. We evaluated the effectiveness of the ATP-CRA assay in determining the chemosensitivity of gastric cancer specimens using eleven chemotherapeutic agents - etoposide, doxorubicin, epirubicin, mytomicin, 5-fluorouracil, oxaliplatin, irinotecan, docetaxel, paclitaxel, methotraxate, and cisplatin - for chemosensitivity studies using ATP-CRA...
December 2010: Journal of Gastric Cancer
Lorenzo Fornaro, Enrico Vasile, Gianluca Masi, Fotios Loupakis, Giacomo Giulio Baldi, Giacomo Allegrini, Lisa Salvatore, Chiara Cremolini, Samanta Cupini, Enrico Cortesi, Alessandro Tuzi, Cristina Granetto, Isa Maura Brunetti, Sergio Ricci, Alfredo Falcone
PURPOSE: FOLFOXIRI demonstrated higher efficacy compared to 5-fluorouracil, leucovorin, irinotecan (FOLFIRI) as first-line treatment of metastatic colorectal cancer. We evaluated the outcome of second-line treatments among 196 patients treated with first-line FOLFOXIRI in three consecutive trials conducted by the Gruppo Oncologico Nord Ovest group. PATIENTS AND METHODS: One hundred seventy-two of 196 patients so far progressed and 136 (79%) received second-line therapies: 32 (24%) were rechallenged with FOLFOXIRI, 52 (38%) were treated with irinotecan- or oxaliplatin-based doublets, and 52 (38%) received fluoropyrimidine plus mytomicin C or single-agent chemotherapy...
March 2012: Clinical Colorectal Cancer
Roberta Buonomo, Ferdinando Giacco, Angela Vasaturo, Sergio Caserta, Stefano Guido, Valentina Pagliara, Corrado Garbi, Gelsomina Mansueto, Angela Cassese, Giuseppe Perruolo, Francesco Oriente, Claudia Miele, Francesco Beguinot, Pietro Formisano
Cell migration is dependent on the control of signaling events that play significant roles in creating contractile force and in contributing to wound closure. We evaluated wound closure in fibroblasts from mice overexpressing (TgPED) or lacking ped/pea-15 (KO), a gene overexpressed in patients with type 2 diabetes. Cultured skin fibroblasts isolated from TgPED mice showed a significant reduction in the ability to recolonize wounded area during scratch assay, compared to control fibroblasts. This difference was observed both in the absence and in the presence of mytomicin C, an inhibitor of mitosis...
May 2012: Journal of Cellular Physiology
Heloisa Andrade Maestrini, Thatiana Almeida Pereira Fernandes, Hérika Danielle De Miranda Santos Matoso, Willer Otávio Guimarães Amaral, Angela Andrade Maestrini
A 70-year-old female patient underwent cataract and glaucoma surgery on her left eye in 1996. Eleven years later, we performed two bleb needling revisions with adjunctive mytomicin-C, in order to decrease an uncontrolled intraocular pressure of 32 mmHg. After the second needling, she developed severe overfiltration, with flat anterior chamber, choroidal effusion, and impending corneal decompensation. Conservative treatment with cycloplegic and corticosteroid eye drops, acetazolamide and therapeutic contact lenses was unsuccessfully tried...
March 2011: Arquivos Brasileiros de Oftalmologia
Bogdan Geavlete, Razvan Multescu, Dragos Georgescu, Marian Jecu, Florin Stanescu, Petrisor Geavlete
OBJECTIVES: •  To evaluate in a prospective, randomized study the impact of hexaminolevulinate blue-light cystoscopy (HAL-BLC) on the diagnostic accuracy and treatment changes in cases of non-muscle invasive bladder cancer (NMIBC) compared with standard white-light cystoscopy (WLC). •  To compare the long-term recurrence rates in the two study arms. PATIENTS AND METHODS: •  In all, 362 patients suspected of NMIBC were included in the trial based on positive urinary cytology and/or ultrasonographic suspicion of bladder tumours and underwent transurethral resection of bladder tumours...
February 2012: BJU International
Edward N Rampersaud, Arie S Belldegrun
No abstract text is available yet for this article.
February 2011: European Urology
Barbara Pinto, Francesca Caciagli, Elisabetta Riccio, Daniela Reali, Ana Sarić, Tihomir Balog, Sasa Likić, Roberto Scarpato
The estrogenic/antiestrogenic activity and the genotoxicity/antigenotoxicity of bee pollen from Salix alba L. and Cystus incanus L. and its derivative extracts in yeast and human cells was investigated. All samples showed a marked inhibitory effect on the activity of the natural estrogen 17 beta-estradiol (higher than 90% for extracts 2) and failed to cause estrogenic activity and chromosome damage. At least one preparation from each species showed a marked antigenotoxic effect against the action of the anticancer drugs mytomicin C, bleomycin, and vincristine...
September 2010: European Journal of Medicinal Chemistry
D Chiseliţă, C Danielescu
This is a case report concerning a patient that was subject to non-penetrating deep sclerectomy (with intraoperative Mytomicin C) for the management of advanced open angle glaucoma in the only functional eye. The surgery was uneventful, the visual acuity was preserved and the intraocular pressure was reduced. After 2 months the patient presented with symptoms of postoperative bleb-related endophthalmitis. The treatment of this condition (including pars plana vitrectomy) did not succeed in preventing a severe retinal necrosis that resulted in the loss of visual acuity This is, to our knowledge, the first published case of endophthalmitis after non-penetrating deep sclerectomy...
2010: Oftalmologia
Bogdan Popa, Monica Popiel, Laurenţiu Gulie, Claudiu Turculeţ, Mircea Beuran
First transcatheter embolization of hepatic artery has been materializing in 1974, in France, for unresectable hepatic tumours. Then, this treatment has become use enough in many countries, especially in Japan, where primary hepatic tumours are very frequent. In this article, we present procedures of interventional endovascular treatment for primary hepatic tumours: chemoembolization, intra-arterial chemotherapy. The study comprises patients with primary hepatic tumours investigated by hepatic-ultrasound and contrast-enhanced CT or MRI...
October 2008: Journal of Medicine and Life
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