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Santi Watiroyram, Anton Brancelj, La-Orsri Sanoamuang
Elaphoidella thailandensis sp. nov. and E. jaesornensis sp. nov., collected during an investigation of cave-dwelling copepod fauna in the northern part of Thailand, are described and figured herein. The new species were collected from pools filled by percolating water from the unsaturated zone of a karstic aquifer in Phitsanulok and Lampang Provinces, respectively. Elaphoidella thailandensis, from Tham Khun cave, is distinguished from its congeners by the two-segmented endopod of pediger 1, the absence of endopod on pediger 4, and the setal formula 4, 5, 6 for the distal exopodal segment of pedigers 2-4...
2015: Zootaxa
Stefan H F Hagmann, Eyal Leshem, Philip R Fischer, William M Stauffer, Elizabeth D Barnett, John C Christenson
BACKGROUND: The International Society of Travel Medicine (ISTM) Pediatric Interest Group (PedIG) was created in 2010. We studied the group's professional characteristics and practice patterns to identify clinical areas requiring further training and research related to pediatric international travel. METHODS: PedIG members were emailed a two-part online questionnaire in September 2011, which comprised questions about professional and practice details, followed by a survey regarding decisions on nine patient scenarios that represent common pediatric pre-travel health challenges...
November 2014: Journal of Travel Medicine
Kate Taylor, Sue Elliott
BACKGROUND: Amblyopia is reduced visual acuity in one or both eyes in the absence of any demonstrable abnormality of the visual pathway. It is not immediately resolved by the correction of refractive error. Strabismus develops in approximately 5% to 8% of the general population. The aim of treatment for amblyopia is to obtain the best possible level of vision in the amblyopic eye. Different treatment options were examined within the review. OBJECTIVES: By reviewing the available evidence we wanted to establish the most effective treatment for strabismic amblyopia...
2014: Cochrane Database of Systematic Reviews
Diana DeSantis
Amblyopia refers to unilateral or bilateral reduction in best corrected visual acuity, not directly attributed to structural abnormality of the eye or posterior visual pathways. Early detection of amblyopia is crucial to obtaining the best response to treatment. Amblyopia responds best to treatment in the first few years of life. In the past several years a series of studies undertaken by the Pediatric Eye Disease Investigator Group (PEDIG) have been designed to evaluate traditional methods for treating amblyopia and provide evidence on which to base treatment decisions...
June 2014: Pediatric Clinics of North America
Katherine A Lee, Danielle L Chandler, Michael X Repka, Michele Melia, Roy W Beck, C Gail Summers, Kevin D Frick, Nicole C Foster, Raymond T Kraker, Scott Atkinson
PURPOSE: To compare the clinical outcomes of two treatment approaches for bilateral nasolacrimal duct obstruction (NLDO) in infancy. DESIGN: Multicenter, randomized clinical trial. METHODS: We studied 57 infants between the ages of 6 and <10 months who had bilateral NLDO. Participants were randomized to receive either (1) immediate office-based probing within two weeks (n = 31) or (2) 6 months of observation and nonsurgical management followed by surgical facility-based probing for unresolved cases (n = 26)...
November 2013: American Journal of Ophthalmology
Noelle Matta, David I Silbert
PURPOSE: We set out to determine the accommodative effects of Atropine on the visual system. METHODS: A prospective study was done on a normal eye in a 31-year-old cooperative adult. One drop of 1% Atropine was instilled and the effect on accommodation, near visual acuity and pupil size was recorded. Accommodation was measured at 1/3 of a meter utilizing the Grand Seiko Auto Refractor. Near visual acuity was measured with the PEDIG ATS 4 near visual acuity test at a set distance of 16 inches...
2013: Binocular Vision & Strabology Quarterly, Simms-Romano's
Ya-Ping Jin, Amy H Y Chow, Linda Colpa, Agnes M F Wong
PURPOSE: To investigate whether the evidence-based recommendations by the Pediatric Eye Disease Investigator Group (PEDIG) as initial treatment of amblyopia have been implemented into clinical practice and to discuss the necessary steps in translating evidence-based knowledge to inform clinical decision making. DESIGN: Retrospective cohort study. PARTICIPANTS: Children with amblyopia seen from 2007 through 2009 by academic and community ophthalmologists in a large urban center in North America that serves a population of more than 8 million...
April 2013: Ophthalmology
Kammi B Gunton
Amblyopia is the most common cause of preventable visual loss in children. This article reviews treatment options, durations, and efficacy in randomized multicentered trials conducted by the Pediatric Eye Disease and Investigator Group in the last decade. Parents and patients should be counseled that many forms of treatment are efficacious, allowing the option of choice of best-tolerated treatment method. Compliance is key to successful treatment. The course of treatment is likely at least 6-12 months, with yearly follow-up suggested once amblyopia has been treated to monitor for regression...
March 2013: Pediatrics
P M VanRaden, T A Cooper, G R Wiggans, J R O'Connell, L R Bacheller
Selection, mating, and improvement of dairy animals have required accurate pedigrees. Genomic tools allow paternal ancestors to be easily confirmed or discovered because most sires are genotyped for many markers, but maternal ancestors are more difficult to discover because most female ancestors are not genotyped. Three methods to discover maternal grandsires (MGS) were developed and compared. Conflicts were counted one single nucleotide polymorphism (SNP) at a time between genotypes of the animal and potential MGS (duo method) or also using the sire's genotype (trio method)...
March 2013: Journal of Dairy Science
Kevin D Frick, Luxme Hariharan, Michael X Repka, Danielle Chandler, B Michele Melia, Roy W Beck
OBJECTIVE: To assess the impact of the rate of spontaneous resolution of congenital nasolacrimal duct obstruction on the relative cost-effectiveness of deferred nasolacrimal duct probing in a surgical facility (DFPS) compared with an immediate office-based probing surgery (IOPS). METHODS: Data from the literature, Medicare 2009 fee schedule, and consensus assumptions were combined to populate a model of outcomes of 2 treatment strategies: immediate office-based probing (IOPS) and deferred facility-based probing (DFPS) (deferred for 6 months)...
May 2011: Archives of Ophthalmology
Megan G Rees, Cindy-Lee Hing Woo, B Optom
INTRODUCTION: The Pediatric Eye Disease Investigator Group (PEDIG), formed in 1997, has been dedicated to clinical research of eye diseases affecting children. Over the last three years, PEDIG has studied the efficacy of amblyopia treatment regimes, and has followed the long-term outcomes of these regimes. These studies are known as the Amblyopia Treatment Studies (ATS) and have been sorted into eight categories. Four of these have been published and four are still awaiting publication...
2007: American Orthoptic Journal
Mike Schmidt, Elizabeth R Hauser, Eden R Martin, Silke Schmidt
We have previously distributed a software package, SIMLA (SIMulation of Linkage and Association), which can be used to generate disease phenotype and marker genotype data in three-generational pedigrees of user-specified structure. To our knowledge, SIMLA is the only publicly available program that can simulate variable levels of both linkage (recombination) and linkage disequilibrium (LD) between marker and disease loci in general pedigrees. While the previous SIMLA version provided flexibility in choosing many parameters relevant for linkage and association mapping of complex human diseases, it did not allow for the segregation of more than one disease locus in a given pedigree and did not incorporate environmental covariates possibly interacting with disease susceptibility genes...
2005: Statistical Applications in Genetics and Molecular Biology
Frits R Rosendaal
Over the last decade we have witnessed an avalanche of newly identified risk factors for venous thrombosis. This has advanced our knowledge of its etiology, because more determinants have been described and because the underlying concepts have received a new and broader understanding. Venous thrombosis is a common multicausal disease occurring as the result of interacting genetic, environmental and behavioral risk factors. Some of these have been known since medieval times, such as the increased risk of thrombosis during immobilization in pregnancy and after childbirth (although retained milk of the breast-feeding mother was seen as the primary cause for the latter)...
2005: Hematology—the Education Program of the American Society of Hematology
Vanessa Tempest, Rachel Iredale, Jonathon Gray, Liz France, Sally Anstey, John Steward
Pedigree construction and disease confirmation are the means by which reported family histories are translated into a verified clinical tool informing risk assessment and management decisions by clinical genetics staff. In this study, we hypothesised that pedigree generation data processes do not generally require the clinical expertise of genetic counsellors and that they could be successfully transferred to nonclinical data administrators. We made a pragmatic comparison of two processes of pedigree generation by different personnel from 14 consecutive family history questionnaires containing 88 living and decease affected individuals...
September 2005: European Journal of Human Genetics: EJHG
Ju-Shey Ho, Il-Hoi Kim, Kazuya Nagasawa
Nine species of psychrolutids kept in the Marine Zoology of Hokkaido University were found to carry eight species of copepod parasites. The parasites and their hosts are: Bobkabata kabatabobbus Hogans and Benz, 1990 on Malacocottus zonurus Bean; Chondracanthus parvus n. sp. on Eurymen gyrinus Gilbert and Burke; Chondracanthus yabei n. sp. on Dasycottus setiger Bean and M. zonurus; Ch. yanezi Atria, 1980 on Psychrolutes phrictus Stein and Bond; Caligus similis n. sp. on Neophrynichthys latus (Hutton); Clavella adunca (Strøm, 1762) on M...
April 2005: Zoological Science
Roy W Beck
The Pediatric Eye Disease Investigator Group (PEDIG) is a network of university-based and community-based pediatric eye care practitioners that is conducting multiple clinical research studies. The group has conducted the Congenital Esotropia Observational Study, which assessed the early course of esotropia in infants, and the Amblyopia Treatment Studies, a series of randomized trials, the first of which compared atropine and patching for treatment of moderate amblyopia in children 3 to <7 years old. Herein, the results of these studies are summarized, and the current and future studies of the group are described...
October 2002: Current Opinion in Ophthalmology
J Ho, C L Lin
A new species of caligid copepod (Siphonostomatoida), Anuretes grandis sp. n., parasitic on the painted sweetlips [Diagramma pictum (Thunberg)] in Taiwan is described. The new species is distinguished from its congeners by having: (1) free margin of cephalothorax not covering fourth pediger, (2) large genital complex longer than 2/3 of the cephalic shield, (3) no maxillary whip, (4) leg 3 with 9 setae on the terminal segment of exopod and 8 plumose setae on the terminal segment of endopod, and (5) armature of I,III on leg 4 exopod...
2000: Folia Parasitologica
A C Chen, G Kalsi, J Brynjolfsson, T Sigmundsson, D Curtis, R Butler, T Read, P Murphy, H Petursson, E A Barnard, H M Gurling
OBJECTIVE: Previous research has consistently implicated genetic factors in the pathogenesis of schizophrenia. It has been hypothesized that an abnormality in glutamatergic function is of etiologic importance in schizophrenia, and therefore the glutamate receptor family of genes are potential susceptibility loci for schizophrenia. To test this hypothesis the authors sought to detect linkage between the GluR6 glutamate receptor gene and schizophrenia. METHOD: Twenty-three English and Icelandic families containing multiple cases of schizophrenia were genotyped with a microsatellite trinucleotide repeat polymorphism localized at the GluR6 glutamate receptor locus...
December 1996: American Journal of Psychiatry
A Uncini, R Lodi, A Di Muzio, G Silvestri, S Servidei, A Lugaresi, S Iotti, P Zaniol, B Barbiroli
Familial hemiplegic migraine (FHM) is a rare autosomal dominant disorder of unknown pathogenesis characterized by migraine and transitory hemiplegic attacks. We describe a kindred fulfilling the diagnostic criteria for FHM in which: (1) brain phosphorus magnetic resonance spectroscopy (31P-MRS) showed a reduced phosphocreatine content accompanied by high [ADP], high percentage of V/Vmax of ATP biosynthesis and decreased phosphorylation potential; (2) muscle 31P-MRS showed a reduced rate of phosphocreatine recovery after exercise; (3) blood lactate was increased after effort; (4) muscle biopsy showed, in one patient, rare ragged red fibers succinate-dehydrogenase positive and cytochrome c oxidase negative; (5) genetic analysis of muscle mitochondrial DNA did not show any of the two point mutations in the tRNA(Leu(UUR)) associated with the MELAS syndrome (Mitochondrial myopathy, Encephalopathy with Lactic Acidosis and Stroke-like episodes)...
April 1995: Journal of the Neurological Sciences
I Heuch, F H Li
No abstract text is available yet for this article.
1972: Clinical Genetics
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