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Chronic otitis media

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https://www.readbyqxmd.com/read/28726587/repair-of-tympanic-membrane-perforations-with-customized-bioprinted-ear-grafts-using-chinchilla-models
#1
Che-Ying Kuo, Emmanuel Wilson, Andrew Fuson, Nidhi Gandhi, Reza Monfaredi, Audrey Jenkins, Maria Romero, Marco Santoro, John P Fisher, Kevin Cleary, Brian Reilly
The goal of this work is to develop an innovative method that combines bioprinting and endoscopic imaging to repair tympanic membrane perforations (TMPs). TMPs are a serious health issue because they can lead to both conductive hearing loss and repeated otitis media. TMPs occur in 3 to 5% of cases after ear tube placement as well as in cases of acute otitis media (the second most common infection in pediatrics), chronic otitis media with or without cholesteatoma, or as a result of barotrauma to the ear. About 55,000 tympanoplasties, the surgery performed to reconstruct TMPs, are performed every year and the commonly used cartilage grafting technique has a success rate between 43% to 100%...
July 20, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28719707/community-triage-of-otology-patients-using-a-store-and-forward-telemedicine-device-a-feasibility-study
#2
Nishi Gupta, Neeraj Chawla, Digant Gupta, Nidhi Dhawan, Vidya R Janaki
Chronic otitis media is a major contributor to acquired hearing loss in developing countries. Developing countries such as India, with huge populations and poor health infrastructures, have always felt the shortage of trained specialists who can provide quality care to meet the enormous demand for treatment of this disease. This pilot study assessed the feasibility of empowering trained health workers equipped with ENTraview, a store-and-forward telemedicine device that integrates a camera- enabled smart phone with an otoscope...
July 2017: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/28718590/-novelties-in-ent-2016
#3
Francis Marchal
These novelties in ENT were selected among more than 15'000 abstracts in the 2016 literature, and dedicated to the practioner Guidelines of the American Academy of ORL will resume the attitude towards chronic otitis media, and reviews of hearing impairment and tinnitus are presented, as well as impact of the pneumoccal vaccine on otitis media. In rhinology, the flora of chronic rhinosinusitis and its non surgical treatments will be discussed, as well as epistaxis and malignant tumor series. 17 Diseases dignanosed only with exhaled air will be also reported...
March 8, 2017: Revue Médicale Suisse
https://www.readbyqxmd.com/read/28716766/simultaneous-coexistence-of-complications-of-chronic-otitis-media-in-the-same-case
#4
Sema Zer Toros, Çiğdem Tepe Karaca, Çiğdem Kalaycık Ertugay, Seniha Şenbayrak, Ömer Çağatay Ertugay, Lütfü Şeneldir
Chronic otitis media (COM) is a common clinical entity, but the incidence of COM complications has declined recently due to broad use of antibiotics. Independent of this, these complications are still a significant challenge in otorhinolaryngology practice because of high morbidity and mortality rates. The most common etiologic diagnosis was cholesteatomatous COM. Simultaneous coexistence of complications of COM in the same case is a rare situation, and the present report describes a case with mastoiditis, Bezold abscess, lateral sinus thrombophlebitis, meningitis, and paraspinal abscess...
July 17, 2017: Journal of International Advanced Otology
https://www.readbyqxmd.com/read/28716763/clinical-characteristics-of-chronic-perforated-otitis-media-in-different-age-groups
#5
Masayo Hasegawa, Akihiro Shinnabe, Hiromi Kanazawa, Yukiko Iino, Naohiro Yoshida
OBJECTIVE: We aimed to analyze preoperative and intraoperative clinical characteristics of chronic perforated otitis media by patient age. MATERIALS AND METHODS: We analyzed 137 tympanoplasties for chronic perforated otitis media in 133 patients. Exclusion criteria were ear adhesions, cholesteatoma, and a history of tympanoplasty. Patients were divided into a younger group (aged 15-39 years), a middle group (40-64 years), and an elderly group (≥65 years). We compared tympanoplasty technique (using Wullstein classification), mastoid air-cell area measured by temporal bone computed tomography, preoperative aeration of the temporal bone, mean preoperative hearing (at 500 Hz, 1000 Hz, and 2000 Hz), and patch effect calculated by the pre- and post-patch air-bone gap at frequencies of 250 Hz and 500 Hz among the three age groups...
July 17, 2017: Journal of International Advanced Otology
https://www.readbyqxmd.com/read/28704899/cochlear-fistula-in-chronic-otitis-media-without-cholesteatoma
#6
Changyun Kwon, Jeong Hwan Choi, Hoon Young Woo
Cochlear fistula in the chronic otitis media (COM) without cholesteatoma is an extremely rare with only a few cases reported in the literature to this date. We describe a case of cochlear fistula observed in a female with COM without cholesteatoma. This report presents the first clinical case of a transtympanic iatrogenic trauma by habitual cotton swabs probably causing cochlear fistula.
July 2017: Journal of Audiology & Otology
https://www.readbyqxmd.com/read/28701289/chronic-pm2-5-exposure-and-risk-of-infant-bronchiolitis-and-otitis-media-clinical-encounters
#7
Mariam S Girguis, Matthew J Strickland, Xuefei Hu, Yang Liu, Howard H Chang, Candice Belanoff, Scott M Bartell, Verónica M Vieira
Chronic particulate matter less than 2.5μm in diameter (PM2.5) exposure can leave infants more susceptible to illness. Our objective is to estimate associations of the chronic PM2.5 exposure with infant bronchiolitis and otitis media (OM) clinical encounters. We obtained all first time bronchiolitis (n=18,029) and OM (n=40,042) clinical encounters among children less than 12 and 36 months of age, respectively, diagnosed from 2001 to 2009 and two controls per case matched on birthdate and gestational age from the Pregnancy to Early Life Longitudinal data linkage system in Massachusetts...
July 1, 2017: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/28699879/d-methionine-interferes-with-non-typeable-haemophilus-influenzae-peptidoglycan-synthesis-during-growth-and-biofilm-formation
#8
Harriet Dawe, Evelin Berger, Carina Sihlbom, Elizabeth M Angus, Robert P Howlin, Jay R Laver, Marc Tebruegge, Luanne Hall-Stoodley, Paul Stoodley, Saul N Faust, Raymond N Allan
Non-typeable Haemophilus influenzae (NTHi) is an opportunistic pathogen that plays a major role in a number of respiratory tract infections, including otitis media, cystic fibrosis and chronic obstructive pulmonary disease. Biofilm formation has been implicated in both NTHi colonization and disease, and is responsible for the increased tolerance of this pathogen towards antibiotic treatment. Targeting metabolic pathways that are important in NTHi biofilm formation represents a potential strategy to combat this antibiotic recalcitrance...
July 12, 2017: Microbiology
https://www.readbyqxmd.com/read/28699273/improved-autologous-cortical-bone-harvest-and-viability-with-2flute-otologic-burs
#9
Adam A Roth, Pei-Ciao Tang, Michael J Ye, Khalid S Mohammad, Rick F Nelson
OBJECTIVES: To determine if 2Flute (Stryker Corporation, Kalamazoo, MI) otologic burs improve the size, cellular content, and bone healing of autologous cortical bone grafts harvested during canal wall reconstruction (CWR) tympanomastoidectomy with mastoid obliteration. STUDY DESIGN: Institutional review board-approved prospective cohort study. METHODS: Human autologous cortical bone chips were harvested using various burs (4 and 6 mm diameter; multiflute, and 2Flute [Stryker Corporation]) from patients undergoing CWR tympanomastoidectomy for the treatment of chronic otitis media with cholesteatoma...
July 12, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28696280/nontypeable-haemophilus-influenzae-releases-dna-and-dnabii-proteins-via-a-t4ss-like-complex-and-come-of-the-type-iv-pilus-machinery
#10
Joseph A Jurcisek, Kenneth L Brockman, Laura A Novotny, Steven D Goodman, Lauren O Bakaletz
Biofilms formed by nontypeable Haemophilus influenzae (NTHI) are central to the chronicity, recurrence, and resistance to treatment of multiple human respiratory tract diseases including otitis media, chronic rhinosinusitis, and exacerbations of both cystic fibrosis and chronic obstructive pulmonary disease. Extracellular DNA (eDNA) and associated DNABII proteins are essential to the overall architecture and structural integrity of biofilms formed by NTHI and all other bacterial pathogens tested to date. Although cell lysis and outer-membrane vesicle extrusion are possible means by which these canonically intracellular components might be released into the extracellular environment for incorporation into the biofilm matrix, we hypothesized that NTHI additionally used a mechanism of active DNA release...
July 10, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28693661/bacterial-strain-changes-during-chronic-otitis-media-surgery
#11
G J Kim, S Yoo, S Han, J Bu, Y Hong, D-K Kim
OBJECTIVE: Cultures obtained from pre-operative middle-ear swabs from patients with chronic otitis media have traditionally been used to guide antibiotic selection. This study investigated changes in the bacterial strains of the middle ear during chronic otitis media surgery. METHODS: Pre-operative bacterial cultures of otorrhoea, and peri-operative cultures of the granulation tissue in either the middle ear or mastoid cavity, were obtained. Post-operative cultures were selectively obtained when otorrhoea developed after surgery...
July 11, 2017: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/28680493/study-of-various-prognostic-factors-affecting-successful-myringoplasty-in-a-tertiary-care-centre
#12
Kripa Dangol, Rakesh Prasad Shrivastav
Introduction  Myringoplasty is a commonly performed otologic surgery. Objectives  The objective of this study is to evaluate the effect of prognostic factors like - size, site of perforation, status of operating ear, approach, status of contralateral ear, experience of surgeon, primary or revision myringoplasty, and smoking in graft uptake, as well as to evaluate the hearing results after myringoplasty. Methods  This is a prospective study. We included in our sample patients aged over 13 years with a Tubotympanic Chronic Otitis Media diagnosis...
July 2017: International Archives of Otorhinolaryngology
https://www.readbyqxmd.com/read/28680491/relation-between-ossicular-erosion-and-destruction-of-facial-and-lateral-semicircular-canals-in-chronic-otitis-media
#13
Suphi Bulğurcu, İlker Burak Arslan, Bünyamin Dikilitaş, İbrahim Çukurova
Introduction  Chronic otitis media can cause multiple middle ear pathogeneses. The surgeon should be aware of relation between ossicular chain erosion and other destructions because of the possibility of complications. Objective  This study aimed to investigate the rates of ossicular erosion in cases of patients with and without facial nerve canal destruction, who had undergone mastoidectomy due to chronic otitis media with or without cholesteatoma. Methods  We retrospectively analyzed three hundred twenty-seven patients who had undergone tympanomastoidectomy between April 2008 and February 2014...
July 2017: International Archives of Otorhinolaryngology
https://www.readbyqxmd.com/read/28674033/haemophilus-parainfluenzae-strain-atcc33392-forms-biofilms-in-vitro-and-during-experimental-otitis-media-infections
#14
Bing Pang, W Edward Swords
Haemophilus parainfluenzae is a nutritionally fastidious, Gram-negative bacterium with an oropharyngeal/nasopharyngeal carriage niche that is associated with a range of opportunistic infections, which include infectious endocarditis and otitis media (OM). These infections are often chronic/recurrent in nature and typically involve bacterial persistence within biofilm communities that are highly resistant to host clearance. This study addresses the primary hypothesis that H. parainfluenzae forms biofilm communities that are important determinants of persistence in vivo The results from in vitro biofilm studies confirmed that H...
July 3, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28669049/endoscopic-versus-microscopic-type-1-tympanoplasty-in-the-same-patients-a-prospective-randomized-controlled-trial
#15
Isa Kaya, Baha Sezgin, Demet Sergin, Arin Ozturk, Sevinc Eraslan, Sercan Gode, Cem Bilgen, Tayfun Kirazli
The aim of this study was to compare the audiologic outcomes of the patients who underwent endoscopy on one ear and microscopic tympanoplasty on the other, and to investigate the operative time, graft success, postoperative pain and health status. This prospective randomized controlled study was carried out in Ege University ENT Department between February 2015 and September 2016. The patients who had bilateral chronic otitis media, normal middle ear mucosa and a hearing loss difference of 10 dB or less between the two ears randomly underwent microscopic tympanoplasty in one ear and endoscopic tympanoplasty in the contralateral ear, with 6-month intervals...
July 1, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28659326/a-cation-binding-surface-protein-as-a-vaccine-antigen-to-prevent-moraxella-catarrhalis-otitis-media-and-infections-in-chronic-obstructive-pulmonary-disease
#16
Timothy F Murphy, Aimee L Brauer, Antoinette Johnson, Gregory E Wilding, Mary Koszelak-Rosenblum, Michael G Malkowski
Moraxella catarrhalis is an exclusively human respiratory tract pathogen that is a common cause of otitis media in children and respiratory tract infections in adults with chronic obstructive pulmonary disease. A vaccine to prevent these infections would have a major impact in reducing the substantial global morbidity and mortality in these populations. Through a genome mining approach, we identified AfeA, an ∼32 kDa substrate binding protein of an ABC transport system as an excellent candidate vaccine antigen...
June 28, 2017: Clinical and Vaccine Immunology: CVI
https://www.readbyqxmd.com/read/28636202/squamous-cell-carcinoma-of-the-temporal-bone-in-30-patients-difference-in-presentation-and-treatment-in-de-novo-disease-vs-radiation-associated-disease
#17
Ho Yee Sun, Raymond K Tsang
No abstract text is available yet for this article.
June 21, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28631681/-the-evaluation-of-the-quality-of-life-in-a-healthy-population-with-the-use-of-the-comq-12-questionnaire
#18
S Ya Kosyakov, Yu V Minavnina, K N Bgantseva, A L Dryupin
The COMQ-12 questionnaire has been elaborated to evaluate the deterioration in the quality of life of the subjects suffering from chronic suppurative otitis media (CSOM) based on the reports of the patients themselves. This questionnaire is of special interest in that it allows to register the complaints of the patients stated by them in the order of priority beginning from those that are responsible for the most pronounced manifestations of the impairment in the quality of life. It, in turn, helps the medical practitioner to rationally organize the treatment of a concrete patient taking into consideration his or her individual expectations...
2017: Vestnik Otorinolaringologii
https://www.readbyqxmd.com/read/28631672/-the-influence-of-interleukin-gene-polymorphism-on-the-serum-cytokine-level-in-the-patients-presenting-with-chonic-suppurative-otitis-media
#19
E V Baike, Yu A Vitkovsky, A A Dutova
The objective of the present work was to study the influence of allelic variant associations of 1-beta interleukin (C3953T, &511C, T31C), interleukin-6 (C174G), and tumour necrosis factor-alpha (G308A) gene polymorphisms on the serum cytokine level in the patients presenting with chronic suppurative otitis media. A total of 299 patients at the age varying from 16 to 55 years with this condition divided into three groups were examined. Group 1 was comprised of 146 patients suffering from the tubotympanic form of chronic suppurative otitis media (CSOM)...
2017: Vestnik Otorinolaringologii
https://www.readbyqxmd.com/read/28625810/evaluating-the-ototoxicity-of-a-anti-mrsa-peptide-kr-12-a2
#20
Chung Man Sung, Hong Chan Kim, Yong Beom Cho, Song Yub Shin, Chul Ho Jang
INTRODUCTION: Methicillin-Resistant Staphylococcus aureus (MRSA) is an emerging problem for the treatment of chronic suppurative otitis media, and also for pediatric tympanostomy tube otorrhea. To date, there are no effective topical antibiotic drugs to treat MRSA otorrhea. OBJECTIVE: In this study, we evaluated the ototoxicity of topical KR-12-a2 solution on the cochlea when it applied topically in the middle ear of guinea pigs. METHODS: The antimicrobial activity of KR-12-a2 against MRSA strains was examined by using the inhibition zone test...
May 31, 2017: Brazilian Journal of Otorhinolaryngology
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