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Chronic otitis media

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https://www.readbyqxmd.com/read/28546484/complete-genome-sequence-of-moraxella-catarrhalis-strain-ccri-195me-isolated-from-the-middle-ear
#1
Aimee Tan, Luke V Blakeway, Lauren O Bakaletz, Matthew Boitano, Tyson A Clark, Jonas Korlach, Michael P Jennings, Ian R Peak, Kate L Seib
Moraxella catarrhalis is an important bacterial pathogen that causes otitis media and exacerbations of chronic obstructive pulmonary disease. Here, we report the complete genome sequence of M. catarrhalis strain CCRI-195ME, which contains the phase-variable epigenetic regulator ModM3.
May 25, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28541245/hearing-loss-in-patients-with-extracranial-complications-of-chronic-otitis-media
#2
Tomasz Przewoźny, Jerzy Kuczkowski
OBJECTIVE: A pure tone audiomety analysis of patients with extracranial complications of chronic suppurative otitis media (ECCSOM). MATERIAL AND METHODS: We retrospectively analyzed audiometric data performed before treatment from 63 patients with ECCSOM (56 single, 7 multiple complications) including groups of frequencies. RESULTS: The greatest levels of hearing loss were noted for 6 and 8 kHz (79.0 and 75.7 dBHL) and for the frequency groups high tone average (76...
June 30, 2017: Otolaryngologia Polska
https://www.readbyqxmd.com/read/28514355/-the-prevalence-of-tympanosclerosis-and-the-effectiveness-of-its-surgical-treatment
#3
E V Garov, N G Sidorina, E E Zagorskaya, P A Sudarev, A S Meparishvili
The objective of the present study was to characterize the epidemiological variants of tympanosclerosis and the effectiveness of the surgical treatment of the patients presenting with this condition. We have undertaken the analysis of the results of 1965 surgical interventions on the patients suffering from different forms of chronic otitis media (COM) performed during the period from 2009 till 2014 with a view to determining the frequency of tympanosclerosis (TSC). In 542 cases, it proved possible to evaluate the intraoperative findings, stages and methods of reconstructive surgery, the anatomical and functional outcomes and effectiveness of the intervention...
2017: Vestnik Otorinolaringologii
https://www.readbyqxmd.com/read/28513418/flagellar-expression-in-clinical-isolates-of-non-typeable-haemophilus-influenzae
#4
Alejandro Carabarin-Lima, Patricia Lozano-Zarain, Miguel Castañeda-Lucio, Claudia Fabiola Martínez de la Peña, Julieta Martinez-Garcia, Norarizbeth Lara Flores, Elías Campos de la Cruz, Sirenia González-Posos, Rosa Del Carmen Rocha-Gracia
PURPOSE: Haemophilus influenzae is a commensal organism found in the upper respiratory tract of humans. When H. influenzae becomes a pathogen, these bacteria can move out of their commensal niche and cause multiple respiratory tract diseases such as otitis media, sinusitis, conjunctivitis and bronchitis in children, and chronic obstructive pulmonary disease in adults. However, H. influenzae is currently considered a non-flagellate bacterium. METHODOLOGY AND RESULTS: In this study, 90 clinical isolates of H...
May 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28498272/paget-s-disease-of-the-temporal-bone-a-single-institution-contemporary-review-of-27-patients
#5
Nicholas L Deep, Jake G Besch-Stokes, John I Lane, Colin L W Driscoll, Matthew L Carlson
OBJECTIVES: To report a contemporary review from a single-institution series on Paget's disease of the temporal bone (PDTB). STUDY DESIGN: Retrospective chart review of patients evaluated from 1998 to 2016. SETTING: Quaternary referral center. PATIENTS: Patients with radiographically confirmed PDTB. MAIN OUTCOME MEASURES: Clinical, audiological, and radiological features and management strategies of PDTB...
May 11, 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28491218/bacterial-agents-of-the-discharging-middle-ear-among-children-seen-at-the-university-of-nigeria-teaching-hospital-enugu
#6
Gideon Chukwudalu Ilechukwu, Chioma Azuka Ilechukwu, Agozie Chukwunedum Ubesie, Ijeoma Okoroafor, Basil Chukwuemeka Ezeanolue, Ngozi Chinyelu Ojinnaka
INTRODUCTION: Discharging middle ear continues to be one of the commonest problems seen in the developing world. There is an ever growing need to carry out studies periodically to determine the common bacterial agents responsible for discharging otitis media and their antibiotic sensitivity especially in set-ups characterized with minimal laboratory services. The study sought to determine the common bacterial agents causing discharging middle ear among children presenting at the University of Nigeria Teaching Hospital, Enugu and their sensitivity to the commonly available antibiotics...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28485112/the-genetics-of-cholesteatoma-a-systematic-review-using-narrative-synthesis
#7
Barbara A Jennings, Peter Prinsley, Carl Philpott, Gavin Willis, Mahmood F Bhutta
OBJECTIVE: A cholesteatoma is a mass of keratinising epithelium in the middle ear. It is a rare disorder that is associated with significant morbidity, and its causative risk factors are poorly understood; on a global scale up to a million people are affected by this each year. We have conducted a systematic literature review to identify reports about the heritability of cholesteatoma or any constitutional genetic factors that may be associated with its aetiology. DATA SOURCES: A systematic search of MEDLINE (EBSCO) and 2 databases of curated genetic research (OMIM and Phenopedia) was conducted...
May 9, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28483223/temporal-bone-extramedullary-hematopoiesis-as-a-causeof-pediatric-bilateral-conductive-hearing-loss-case-report-and-review-of-the-literature
#8
Alexander Lanigan, M Taylor Fordham
Extramedullary hematopoiesis occurs in children with hemoglobinopathy and chronic anemia. The liver and spleen are often affected first, but other foci can develop to support erythrocyte demand. We report a case of a nine-year-old with beta thalassemia and temporal bone extramedullary hematopoiesis causing ossicular fixation and bilateral conductive hearing loss. There is only one case in the literature describing this phenomenon in pediatric patients, and this is the first case report of bilateral hearing loss from this physiologic phenomenon...
June 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28477429/higher-serum-25-oh-d-concentration-is-associated-with-lower-risk-of-chronic-otitis-media-with-effusion-a-case-control-study
#9
Rebecca E Walker, Jim Bartley, Carlos A Camargo, David Flint, John M D Thompson, Edwin A Mitchell
AIM: Vitamin D supplementation and higher 25(OH)-vitamin D concentration are associated with reduced risk of acute respiratory infection. This study examined whether there is a similar association between higher serum 25(OH)D concentration and lower risk of chronic otitis media with effusion (COME). METHODS: In a case-control study, serum 25(OH)D concentration in children referred for tympanostomy tube placement for COME (n=178) was compared to that of healthy children randomly sampled from primary care practices (n=179)...
May 6, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28476655/comparison-between-clinical-and-audiological-results-of-tympanoplasty-with-modified-sandwich-technique-and-underlay-technique
#10
Sanjana Vijay Nemade, Kiran Jaywant Shinde, Chetana Shivadas Naik, Haris Qadri
INTRODUCTION: Surgical repair of the tympanic membrane, termed a type one tympanoplasty is a tried and tested treatment modality. Overlay or underlay technique of tympanoplasty is common. Sandwich tympanoplasty is the combined overlay and underlay grafting of tympanic membrane. OBJECTIVE: To describe and evaluate the modified sandwich graft (mediolateral graft) tympanoplasty using temporalis fascia and areolar fascia. To compare the clinical and audiological outcome of modified sandwich tympanoplasty with underlay tympanoplasty...
April 21, 2017: Brazilian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/28471720/effects-of-mechanical-trauma-to-the-human-tympanic-membrane-an-experimental-study-using-transmission-electron-microscopy
#11
Nadine Schart-Morén, Paula Mannström, Helge Rask-Andersen, Magnus von Unge
HYPOTHESIS: To examine the cellular events following induced superficial lesions of the human tympanic membrane (TM). Such information could lead to enhanced appreciation of repair mechanisms and novel strategies to restore TM perforations. BACKGROUND: Persistent perforation of the TM in chronic otitis media is a major global health problem and frequently necessitates surgical intervention. Most TM perforations heal spontaneously and swiftly, but sometimes healing fails...
May 4, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28468213/can-serum-neutrophil-to-lymphocyte-ratio-be-a-predictive-biomarker-to-help-differentiate-active-chronic-otitis-media-from-inactive-chronic-otitis-media
#12
Hasan Deniz Tansuker, Sinan Eroğlu, Alper Yenigün, Ümit Taşkin, Mehmet Faruk Oktay
OBJECTIVES: The authors' aim was to investigate whether serum neutrophil to lymphocyte ratio might be used as a predictive biomarker to help differentiate active from inactive chronic otitis media (COM). METHODS: Two hundred fifty-nine patients having inactive COM received tympanoplasty without mastoidectomy and were identified as Group 1. On the other hand, 254 patients having active COM received tympanoplasty with mastoidectomy and were identified as Group 2. Routine hemogram tests were performed preoperatively for both the groups...
May 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28468206/the-predictive-value-of-neutrophil-lymphocyte-and-platelet-lymphocyte-ratio-for-the-effusion-viscosity-in-otitis-media-with-chronic-effusion
#13
Mustafa Suphi Elbistanli, Hasan Emre Koçak, Harun Acipayam, Ayşe Pelin Yiğider, Mehmet Keskin, Fatma Tülin Kayhan
OBJECTIVE: The objective of the authors' study was to investigate the predictive value of the neutrophil-lymphocyte rate (NLR) and platelet-lymphocyte rate (PLR) in otitis media with effusion and the correlation of the effusion type with these ratios. STUDY DESIGN: Retrospective case-control study. METHODS: One hundred twenty-six pediatric patients diagnosed otitis media with chronic effusion and had ventilation tube inserted between October 2015 and July 2016 were included in the study group and 124 healthy children, who applied for the routine examination and had blood count analysis, were included in the control group...
May 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28468135/radiological-imaging-of-rare-intracranial-complications-secondary-to-otitis-media-and-mastoiditis
#14
Gülen Burakgazi, Hanifi Bayaroğullari, Fatma Öztürk, Cengiz Arli, Vicdan Köksaldi Motor, Rasim Yanmaz, Nesrin Atci
Acute otitis media used to cause fatal results because of its intracranial complications before the introduction of potent and effective antibiotics. After the introduction of antibiotics, complications have started to be observed more frequently as a result of chronic otitis media and especially in children. Because clinical findings changed and became indistinct, the diagnosis of otitis and mastoiditis has been made occasionally with imaging findings only after complications occurred. Multidetector computed tomography and magnetic resonance imaging are efficient and sufficient methods in the rapid diagnosis and should be immediately referred methods...
May 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28466356/recurrent-otorrhea-in-chronic-suppurative-otitis-media-is-biofilm-the-missing-link
#15
Ramon Gordon Jensen, Helle Krogh Johansen, Thomas Bjarnsholt, Steffen Robert Eickhardt-Sørensen, Preben Homøe
Dispersal of bacteria from a biofilm in the middle ear, serving as a bacterial reservoir, could explain the recurrent and chronic nature of chronic suppurative otitis media (CSOM). The objective of this study is to investigate if the same strains of bacteria could be detected in repeated episodes of otorrhea in CSOM. In a prospective case series at a primary healthcare clinic in Nuuk, Greenland, patients with more than 14 days of otorrhea were included consecutively. Samples for culturing and biofilm analysis were taken at enrollment and at any subsequent episode with otorrhea...
May 2, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28465813/sensorineural-hearing-loss-in-patients-with-chronic-suppurative-otitis-media-is-there-a-significant-correlation
#16
Amin Amali, Nima Hosseinzadeh, Shahram Samadi, Shirin Nasiri, Jayran Zebardast
INTRODUCTION: Hearing loss as a sequel of chronic suppurative otitis media (CSOM) is often conductive, but recent studies have found an additional sensorineural component in these patients, thus demonstrating inner ear damage. The aim of the study was to determine the association between CSOM and sensorineural hearing loss (SNHL) and to assess the influence of patient's age, duration of disease, and presence of cholesteatoma and ossicular erosion on the degree of SNHL. METHODS: In a retrospective study, the medical records of 119 patients who underwent surgery was reviewed...
February 2017: Electronic Physician
https://www.readbyqxmd.com/read/28460120/post-neonatal-tetanus-in-a-picu-of-a-developing-economy-intensive-care-needs-outcome-and-predictors-of-mortality
#17
Suresh Kumar Angurana, Muralidharan Jayashree, Arun Bansal, Sunit Singhi, Karthi Nallasamy
Objectives: To evaluate pediatric intensive care unit (PICU) needs, outcome and predictors of mortality in post-neonatal tetanus. Materials and methods: Review of 30 consecutive post-neonatal tetanus cases aged 1 months to 12 years admitted to a PICU in north India over a period of 10 years (January 2006 to December 2015). Results: Chronic suppurative otitis media was the commonest portal of entry. All received tetanus toxoid, human tetanus immunoglobulin (HTIG) and appropriate antibiotics; 7 (23...
April 27, 2017: Journal of Tropical Pediatrics
https://www.readbyqxmd.com/read/28459043/in-vitro-multi-species-biofilms-of-methicillin-resistant-staphylococcus-aureus-and-pseudomonas-aeruginosa-and-their-host-interaction-during-in-vivo-colonization-of-an-otitis-media-rat-model
#18
Mukesh K Yadav, Sung-Won Chae, Yoon Young Go, Gi Jung Im, Jae-Jun Song
Staphylococcus aureus (SA) and Pseudomonas aeruginosa (PA) are known to cause biofilm-related infections. MRSA and PA have been frequently isolated from chronically infected wounds, cystic fibrosis, chronic suppurative otitis media (CSOM), and from indwelling medical devices, and these bacteria co-exist; however, their interaction with each-other or with the host is not well known. In this study, we investigated MRSA and PA multi-species biofilm communities in vitro and their interaction with the host during in vivo colonization using an OM rat-model...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28455742/eosinophilic-otitis-media-the-aftermath-of-eosinophil-extracellular-trap-cell-death
#19
REVIEW
Shigeharu Ueki, Nobuo Ohta, Masahide Takeda, Yasunori Konno, Makoto Hirokawa
PURPOSE OF REVIEW: Eosinophilic otitis media (EOM) is a refractory disease characterized by the accumulation of eosinophils in middle ear effusion and mucosa. We summarize current knowledge regarding the clinical characteristics and management of EOM. Although eosinophil activation in inflamed foci is involved in the pathogenesis of EOM, little is known about the fate of the eosinophils and aftermath of their cell death. We discuss the possibility that eosinophils undergo non-apoptotic cell death that worsens tissue damage and increases effusion viscosity...
May 2017: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/28448401/clinical-significance-of-incidentally-detected-torus-tubarius-calcification
#20
Karen Buch, Rohini N Nadgir, Muhammad Mustafa Qureshi, Al Ozonoff, Osamu Sakai
OBJECTIVES: Calcification of the torus tubarius has been rarely reported in the literature. Histopathologic studies have previously described cases of Eustachian tube calcification and cite an association with increasing patient age. The purpose of this study was to examine the prevalence of torus tubarius calcification and potential clinical significance on an unrestricted patient population using thin-section computed tomography (CT), which has not been previously reported. METHODS: After the institutional review board approval, 1571 consecutive patients who underwent noncontrast head CT between January 2011 and July 2011 were retrospectively reviewed for torus tubarius calcification...
April 26, 2017: Journal of Computer Assisted Tomography
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