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Chronic otitis media

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https://www.readbyqxmd.com/read/28440726/expression-of-c-type-lectin-receptor-mrna-in-chronic-otitis-media-with-cholesteatoma
#1
Sang Hoon Kim, Seung-Ho Han, Jae Yong Byun, Moon Suh Park, Young Il Kim, Seung Geun Yeo
CONCLUSIONS: The levels of expression of various C-type lectin receptors (CLRs) messenger ribo nucleic acids (mRNAs) were significantly higher in cholesteatomas than in normal skin, suggesting that these CLRs may be involved in the pathogenesis of cholesteatoma. OBJECTIVES: Altered expression of pattern recognition receptors may be associated with immune responses in patients with cholesteatoma. This study assessed the levels of expression of CLR mRNAs in normal skin and in cholesteatoma...
June 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28439691/comparison-of-endoscopic-and-microscopic-tympanoplasty
#2
Che-Hung Kuo, Hsing-Mei Wu
Tympanoplasty was conventionally performed using a microscope for decades. However, since the endoscope began to be used in middle ear surgery in the 1970s, endoscopic tympanoplasty has gained increasing attention. The main objective of this study was to compare endoscopic and microscopic tympanoplasty with and without ossiculoplasty, demonstrating the potential advantages, disadvantages, and outcomes of each. This retrospective study included 126 patients with chronic otitis media who received tympanoplasty from 2013 to 2015 in our hospital...
April 24, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28431842/significance-of-intraoperative-findings-in-revision-tympanomastoidectomy
#3
Andro Košec, Iva Kelava, Jakov Ajduk, Mihael Ries, Robert Trotić, Vladimir Bedeković
PURPOSE: The study was designed to assess correlations between intraoperative findings in revision tympanomastoidectomy as predictors of cholesteatoma recurrence. MATERIALS AND METHODS: A retrospective single-institution cohort of 101 patients who underwent surgical treatment for recurrent chronic otitis media in a tertiary referral otology centre. RESULTS: Out of 101 patients, 65 had canal wall up and 36 canal wall down revision surgery. There were 35 cholesteatoma recurrences...
April 12, 2017: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/28431494/surgical-results-of-modified-canal-wall-down-tympanoplasty
#4
Feng-Ming Gu, Fang-Lu Chi
CONCLUSION: Patients with mastoiditis and chronic suppurative otitis media which has small mastoids that make them ideal candidates for modified canal wall down mastoidectomy (MCWD) which contributes to a dry and spacious ear and the maintaining and improving hearing. OBJECTIVES: To evaluate surgical outcomes for chronic otitis media underwent MCWD. METHODS: A clinical retrospective study was performed on 47 ears with chronic otitis media which has relatively limited attic lesions have the small, sclerotic and hypocellular mastoids according to the preoperative high-resolution CT scan of the temporal bone that underwent MCWD and 32 ears with typical canal wall down operation form January 2010 to January 2016...
April 21, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28417109/intractable-methicillin-resistant-staphylococcus-aureus-otorrhea-with-silicone-impression-in-the-middle-ear
#5
Eun Kyung Jung, Chul Ho Jang, Jong Yuap Seong, Yong Beom Cho
We report a case of methicillin-resistant Staphylococcus aureus (MRSA) otorrhea with impression material of hearing aid in the middle ear. The patient had chronic otitis media in the right ear with sensorineural hearing loss in both ears. The silicone flowed into the middle ear through a tympanic membrane perforation during the process of making an ear mold. Several days after hearing aid fitting, the patient had severe otalgia, intractable otorrhea, aggravated hearing loss, and dizziness. The pus culture and sensitivity test revealed MRSA...
April 2017: Journal of Audiology & Otology
https://www.readbyqxmd.com/read/28414607/cardiac-arrest-in-an-american-cocker-spaniel-during-a-deep-ear-flush-procedure
#6
Alexandra Gould, Fernando L Garcia-Pereira, W Dunbar Gram
CASE DESCRIPTION A 14-year-old spayed female American Cocker Spaniel with bilateral otitis media and no evidence of cardiovascular instability was anesthetized to allow performance of a deep ear flush. CLINICAL FINDINGS Otoscopic examination of the left ear revealed evidence of chronic inflammation; the ear was flushed with sterile saline (0.9% NaCl) solution. Examination of the right ear revealed more severe chronic inflammation than in the left ear, including a ruptured tympanum (timing of rupture unknown)...
May 1, 2017: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/28397271/microbiomes-of-the-normal-middle-ear-and-ears-with-chronic-otitis-media
#7
Shujiro B Minami, Hideki Mutai, Tomoko Suzuki, Arata Horii, Naoki Oishi, Koichiro Wasano, Motoyasu Katsura, Fujinobu Tanaka, Tetsuya Takiguchi, Masato Fujii, Kimitaka Kaga
OBJECTIVE: The aim of this study was to profile and compare the middle ear microbiomes of human subjects with and without chronic otitis media. STUDY DESIGN: Prospective multicenter cohort study. METHODS: All consecutive patients undergoing tympanoplasty surgery for chronic otitis media or ear surgery for conditions other than otitis media were recruited. Sterile swab samples were collected from the middle ear mucosa during surgery. The variable region 4 of the 16S rRNA gene in each sample were amplified using region-specific primers adapted for the Illumina MiSeq sequencer (Illumina, CA, USA))...
April 11, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28393055/outcome-of-incus-interposition-after-preservation-in-soft-tissue
#8
Mohammad Faramarzi, Sareh Roosta, Mahboobe Dianat
INTRODUCTION: The lenticular process of the incus succumbs to necrosis in chronic otitis media. Few researchers have addressed the issue of autograft incus preservation in the soft tissue of the tragus or mastoid cavity. Nonetheless, preservation of the incus in this method during the second stage of ossiculoplasty is a subject that is still up for debate. This study was carried out to demonstrate the hearing outcome after a modification of the incus interposition technique, which involved preserving it in the periauricular soft tissue...
March 2017: Iranian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/28393054/otitis-media-with-effusion-in-children-and-the-impact-of-risk-factors-on-serum-cytokine-levels
#9
Saba Arshi, Fatemeh Dehghani Firouzabadi, Babak Ghalehbaghi, Ali Dehghani Firouzabadi, Farhad Jalali, Mehdi Shekarabi, Reza Sirous, Mohammad Dehghani Firouzabadi
INTRODUCTION: To evaluate the role of allergic-type and infectious-type cytokines in children with chronic otitis media with effusion (OME). MATERIALS AND METHODS: We investigated serum levels of interleukins (IL)-4, IL-5, and IL-13, along with interferon-gamma (IFN-γ) and tumor necrosis factor-alpha (TNF-α), by enzyme-linked immunosorbent assay (ELISA) in 35 children with OME and 28 healthy controls. RESULTS: Children with OME had significantly higher levels of IL-5 in comparison with the control group, ranging from 1 pg/ml in cases to 0...
March 2017: Iranian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/28390803/eustachian-tube-diameter-is-it-associated-with-chronic-otitis-media-development
#10
Ceki Paltura, Tuba Selçuk Can, Behice Kaniye Yilmaz, Mehmet Emre Dinç, Ömer Necati Develioğlu, Mehmet Külekçi
OBJECTIVE: To evaluate the effect of ET diameter on Chronic Otitis Media (COM) pathogenesis. STUDY DESIGN: Retrospective. SUBJECTS AND METHODS: Patients with unilateral COM disease are included in the study. The connection between fibrocartilaginous and osseous segments of the Eustachian Tube (ET) on axial Computed Tomography (CT) images was defined and the diameter of this segment is measured. The measurements were carried out bilaterally and statistically compared...
March 31, 2017: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/28386500/diagnostic-bedside-vestibuloocular-reflex-evaluation-in-the-setting-of-a-false-negative-fistula-test-in-cholesteatoma-of-the-middle-ear
#11
Ricardo D'Albora, Ligia Silveira, Sergio Carmona, Nicolas Perez-Fernandez
Background. False negative fistula testing in patients with chronic suppurative otitis media is a dilemma when proceeding to surgery. It is imperative to rule out a dead labyrinth or a mass effect secondary to the cholesteatoma in an otherwise normally functioning inner ear. We present a case series of three patients in whom a bedside vestibuloocular reflex (VOR) evaluation using a head impulse test was used successfully for further evaluation prior to surgery. Results. In all three cases with a false negative fistula test we were able to further evaluate at the bedside and were not only able to register the abnormal VOR but also localize its deterioration to a particular semicircular canal eroded by the fistula...
2017: Case Reports in Otolaryngology
https://www.readbyqxmd.com/read/28381402/transcutaneous-immunization-with-a-bandaid-prevents-experimental-otitis-media-in-a-polymicrobial-model
#12
Laura A Novotny, John D Clements, Steven D Goodman, Lauren O Bakaletz
Otitis media (OM) is a common pediatric disease and nontypeable Haemophilus influenzae (NTHI) is the predominant pathogen in chronic OM, recurrent OM and OM associated with treatment failure. OM is also a polymicrobial disease, wherein an upper respiratory tract viral infection predisposes to ascension of NTHI from the nasopharynx, the site of colonization, to the normally sterile middle ear, resulting in disease. Using a clinically relevant viral-bacterial co-infection model of NTHI-induced OM, we performed transcutaneous immunization (TCI) via a bandaid delivery system to administer each of three promising NTHI vaccine candidates derived from bacterial adhesive proteins and biofilm mediators: rsPilA, chimV4 and integration host factor...
April 5, 2017: Clinical and Vaccine Immunology: CVI
https://www.readbyqxmd.com/read/28374871/quality-of-life-measurements-for-patients-with-chronic-suppurative-otitis-media-italian-adaptation-of-chronic-ear-survey
#13
G Ralli, C Milella, M Ralli, M Fusconi, G La Torre
The chronic ear survey (CES) is a sensitive and disease specific quality of life (QoL) measurement tool in patients with chronic suppurative otitis media (CSOM). It is a 13-item survey that evaluates the frequency, duration and severity of problems associated with this disease. It is composed of three subscales that describe activity restrictions, symptoms and medical resource utilisation. Based on patient's answers, it is possible to obtain a score resulting in a scale ranging from 0 to 100; the highest indicates the best health, while the lowest denotes poor health...
February 2017: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/28372534/panel-7-otitis-media-treatment-and-complications
#14
Anne G M Schilder, Tal Marom, Mahmood F Bhutta, Margaretha L Casselbrant, Harvey Coates, Marie Gisselsson-Solén, Amanda J Hall, Paola Marchisio, Aino Ruohola, Roderick P Venekamp, Ellen M Mandel
Objective We aimed to summarize key articles published between 2011 and 2015 on the treatment of (recurrent) acute otitis media, otitis media with effusion, tympanostomy tube otorrhea, chronic suppurative otitis media and complications of otitis media, and their implications for clinical practice. Data Sources PubMed, Ovid Medline, the Cochrane Library, and Clinical Evidence (BMJ Publishing). Review Methods All types of articles related to otitis media treatment and complications between June 2011 and March 2015 were identified...
April 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28372531/panel-1-epidemiology-and-diagnosis
#15
Preben Homøe, Kari Kværner, Janet R Casey, Roger A M J Damoiseaux, Thijs M A van Dongen, Hasantha Gunasekera, Ramon G Jensen, Ellen Kvestad, Peter S Morris, Heather M Weinreich
Objective To create a literature review between 2011 and June 1, 2015, on advances in otitis media (OM) epidemiology and diagnosis (including relevant audiology studies). Data Sources Electronic search engines (PubMed, EMBASE, and Cochrane Library) with a predefined search strategy. Review Methods Articles with appropriate epidemiologic methodology for OM, including acute mastoiditis and eustachian tube dysfunction. Items included OM worldwide and in high-risk populations, OM-related hearing loss, news in OM diagnostics, prenatal risk factors and comorbidities, postnatal risk factors, genetics, microbiological epidemiology, guidelines, and quality of life...
April 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28358397/cilia-distribution-and-polarity-in-the-epithelial-lining-of-the-mouse-middle-ear-cavity
#16
Wenwei Luo, Hong Yi, Jeannette Taylor, Jian-Dong Li, Fanglu Chi, N Wendell Todd, Xi Lin, Dongdong Ren, Ping Chen
The middle ear conducts sound to the cochlea for hearing. Otitis media (OM) is the most common illness in childhood. Moreover, chronic OM with effusion (COME) is the leading cause of conductive hearing loss. Clinically, COME is highly associated with Primary Ciliary Dyskinesia, implicating significant contributions of cilia dysfunction to COME. The understanding of middle ear cilia properties that are critical to OM susceptibility, however, is limited. Here, we confirmed the presence of a ciliated region near the Eustachian tube orifice at the ventral region of the middle ear cavity, consisting mostly of a lumen layer of multi-ciliated and a layer of Keratin-5-positive basal cells...
March 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28357413/next-generation-sequencing-combined-with-specific-pcr-assays-to-determine-the-bacterial-16s-rrna-gene-profiles-of-middle-ear-fluid-collected-from-children-with-acute-otitis-media
#17
Saara Sillanpää, Lenka Kramna, Sami Oikarinen, Markku Sipilä, Markus Rautiainen, Janne Aittoniemi, Jussi Laranne, Heikki Hyöty, Ondrej Cinek
The aim of the study was to analyze the bacteriome of acute otitis media with a novel modification of next-generation sequencing techniques. Outpatient children with acute otitis media were enrolled in the study, and middle ear fluids were collected during 90 episodes from 79 subjects aged 5 to 42 months (median age, 19 months). The bacteriome profiles of middle ear fluid samples were determined by a nested-PCR amplification of the 16S rRNA gene (V4 region), followed by mass sequencing. The profiling results were compared to the results of specific PCR assays targeting selected prevalent pathogens...
March 2017: MSphere
https://www.readbyqxmd.com/read/28345505/international-recognition-of-the-chronic-otitis-media-questionnaire-12
#18
S I Kosyakov, J V Minavnina, J S Phillips, M W Yung
OBJECTIVE: The Chronic Otitis Media Questionnaire 12 was developed initially in the UK to assess patient-reported health-related quality of life associated with chronic otitis media. This study aimed to determine whether this tool is applicable to the Russian population, which has a materially different healthcare system. METHOD: A total of 108 patients with different forms of chronic otitis media completed the Russian Chronic Otitis Media Questionnaire 12. RESULTS: The average Russian Chronic Otitis Media Questionnaire 12 score was 19...
March 27, 2017: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/28336588/draft-genome-sequences-of-three-nontypeable-strains-of-haemophilus-influenzae-c188-r535-and-1200-isolated-from-different-types-of-disease
#19
Ulrike Kappler, Rabeb Dhouib, Remya Purushothaman Nair, Alastair G McEwan
Nontypeable Haemophilus influenzae is a persistent human respiratory pathogen known to be involved in a range of acute and chronic respiratory diseases. Here, we report the genome sequences of three H. influenzae strains isolated from sputum, otitis media, and blood. Comparative analyses revealed significant differences in the gene contents including the presence of genes mediating antibiotic resistance.
March 23, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28333779/impact-of-chronic-suppurative-otitis-media-in-pediatric-cochlear-implant-recipients-insight-into-the-challenges-from-a-tertiary-referral-center-in-uk
#20
Paramita Baruah, Kate Hanvey, Richard Irving, Konstance Tzifa
OBJECTIVE: Analyze the presentation and evolution of chronic suppurative otitis media (CSOM) in children with cochlear implants (CI) and explore the merit of early intervention. STUDY DESIGN: Retrospective patient review. SETTING: Tertiary referral hospital and cochlear implant programme. PATIENTS: Children with a CI who developed CSOM. INTERVENTION: Tympanoplasty. MAIN OUTCOME MEASURES: Disease control, recurrence of cholesteatoma, cochlear implant preservation...
March 22, 2017: Otology & Neurotology
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