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Panuveitis

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https://www.readbyqxmd.com/read/28157425/clinical-features-and-prognostic-factors-in-presumed-ocular-tuberculosis
#1
Cristhian A Urzua, Yrbani Lantigua, Sergio Abuauad, Paulina Liberman, Osvaldo Berger, Pablo Sabat, Victor Velasquez, Enzo Castiglione, Margarita Calonge
PURPOSE: To characterize the clinical features in patients with presumed ocular tuberculosis (TB) and determine prognostic factors of visual outcomes and complications in this disease. MATERIAL AND METHODS: Retrospective case series of 35 patients (29 females, 6 males) with presumed ocular TB from referral centers in Chile and Spain between 2002 and 2012. Medical records were reviewed, and data regarding clinical features, complications, best-corrected visual acuity (BCVA), duration of disease, extraocular manifestations, and therapy were retrieved...
February 3, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28145942/clinical-pathologic-correlation-of-sarcoidosis-associated-multifocal-chorioretinitis-in-an-elderly-patient
#2
Mohamed G A Saleh, John L OʼDonnell, Ronald P Davis, David Wilson, Phoebe Lin
BACKGROUND/PURPOSE: To describe a case of histopathologic clinical correlation of sarcoidosis-related multifocal chorioretinitis in an elderly individual. METHODS: This is a single case report and review of the pertinent literature. A 72-year-old white woman with a history of asthma was referred with bilateral asymmetric low-grade chronic panuveitis with advancing peripheral punched-out chorioretinal lesions despite systemic corticosteroid treatment. RESULTS: Coalescent chorioretinal punched-out lesions on fundus examination in the more severely affected right eye did not respond to corticosteroid treatment, and the refractory nature resulted in a suspicion of intraocular lymphoma despite a previous inconclusive diagnostic vitrectomy result...
January 31, 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/28140700/adalimumab-for-the-treatment-of-uveitis
#3
Kara C LaMattina, Debra A Goldstein
Adalimumab, an inhibitor of tumor necrosis factor-alpha (TNFα), is the only systemic non-corticosteroid agent which has been approved by the US Food and Drug Administration (FDA) for the treatment of non-infectious uveitis. Areas covered:The aim of this review is to summarize the research which demonstrated the effectiveness of adalimumab in the treatment of intraocular inflammation and helped to establish its side effect profile, ultimately leading to its FDA approval. Expert commentary:Adalimumab is a useful second-line agent in the treatment of non-infectious uveitis...
January 31, 2017: Expert Review of Clinical Immunology
https://www.readbyqxmd.com/read/28112089/the-intraocular-cd4-cd8-ratio-in-a-black-south-african-patient-with-beh%C3%A3-et-s-disease-uveitis
#4
A Makgotloe
A 33-year-old black South African male patient was referred to our uveitis service with a 5-year history of panuveitis refractory to treatment. He had an associated history of recurrent mouth and genital ulcers, predating the uveitis history by about 2 years. The measurement of his intraocular CD4/CD8 ratio helped make a diagnosis of Behçet's disease uveitis.
December 21, 2016: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/28070744/changes-in-patterns-of-uveitis-at-a-tertiary-referral-center-in-northern-italy-analysis-of-990-consecutive-cases
#5
Cimino Luca, Aldigeri Raffaella, Marchi Sylvia, Mastrofilippo Valentina, Viscogliosi Fabiana, Coassin Marco, Soldani Annamaria, Savoldi Luisa, De Fanti Alessandro, Belloni Lucia, Zerbini Alessandro, Parmeggiani Maria, Chersich Matthew, Soriano Alessandra, Salvarani Carlo, Fontana Luigi
PURPOSE: The role of uveitis, an uncommon ocular disease, is often neglected in research and treatment of autoimmune conditions. The study described the spectrum of uveitis at a referral center in North Italy, and compared that to a previously published series of patients. METHODS: We reviewed all patients with uveitis diagnosed from 2013 to 2015 at the Immunology Eye Unit, Arcispedale S. M. Nuova-IRCCS, Reggio Emilia, Italy. We examined patient characteristics, disease spectrum, and etiologies...
January 9, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28035499/treatment-outcome-in-patients-with-presumed-tubercular-uveitis-at-a-tertiary-referral-eye-care-centre-in-singapore
#6
Leslie Ang, Aera Kee, Tun Hang Yeo, V G Dinesh, Su Ling Ho, Stephen C Teoh, Rupesh Agrawal
AIM: To report the clinical features and outcome of patients with presumed tubercular uveitis (TBU). METHODS: Retrospective analysis of patients with presumed TBU at a tertiary referral eye care centre in Singapore between 2007 and 2012 was done. Main outcome measures were failure of complete resolution of uveitis or recurrence of inflammation. RESULTS: Fifty three patients with mean age of 44.18 ± 15.26 years with 54.72% being males were included...
December 29, 2016: International Ophthalmology
https://www.readbyqxmd.com/read/28018458/successful-treatment-of-tubulointerstitial-nephritis-and-uveitis-with-steroid-and-azathioprine-in-a-12-year-old-boy
#7
Ji Eun Kim, Se Jin Park, Ji Young Oh, Hyeon Joo Jeong, Ji Hong Kim, Jae Il Shin
Tubulointerstitial nephritis and uveitis (TINU) syndrome is a rare disease, often underdiagnosed or misdiagnosed in children. We describe the case of a 12-year-old boy who presented to Severance Hospital with a 1-month history of bilateral conjunctival injection. He was first evaluated by an Ophthalmologist in another hospital and diagnosed with panuveitis. Laboratory tests indicated renal failure, and a renal biopsy confirmed the diagnosis of acute tubulointerstitial nephritis. An extensive exclusion of all possible causes allowed a diagnosis of TINU syndrome...
November 2016: Korean Journal of Pediatrics
https://www.readbyqxmd.com/read/28010155/change-in-visual-function-in-uveitis-patients-after-treatment-an-experience-from-nepal
#8
Nita Sunam Gamal, Ranju Kharel Sitaula, Dev Narayan Shah
PURPOSE: To assess the change in visual function in uveitis patients after treatment. MATERIALS AND METHODS: This one and a half year prospective study was conducted among 180 new uveitis patients. A questionnaire was used to assess the visual function in uveitis cases and analysis of effect size change was also done. RESULTS: The male to female ratio was 1.3:1. The mean vision at presentation was 0.49 logMAR units, which improved to 0.39 logMAR units and 0...
December 23, 2016: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/28005178/-vogt-koyanagi-harada-syndrome-an-unusual-case-with-lacquer-crack-like-retinal-findings
#9
M Parlak, G Kocaoglu, A O Saatci
We report the case of a 35-year-old female patient with bilateral and recurrent panuveitis. Diagnosed with Vogt-Koyanagi-Harada syndrome, the patient was treated with corticosteroids, achieving rapid improvement of functional and morphological findings. After recovery of the exudative retinal detachment, peripapillary lacquer crack-like findings were observed.
December 22, 2016: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/27998457/-the-application-of-ultra-wide-field-angiography-in-the-evaluation-and-management-of-patients-with-posterior-and-panuveitis
#10
Y Chi, C Y Guo, Y Peng, L J Qiao, L Yang
Objective: To evaluate the clinical application of ultra-wide-field fluorescein angiography in posterior and panuveitis patients. Methods: It's a prospective, observational case series study. A total of 82 eyes of 42 patients conformed to the research criteria of posterior and panuveitis. Clinical examinations, conventional fluorescein angiography and ultra-wide-field fluorescein angiograms were performed for each patient. The main outcome was the detection of peripheral retinal changes by ultra-wide-field fluorescein angiography, and how these changes influenced the evaluation and management of the disease...
December 11, 2016: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/27971870/health-care-resource-utilization-and-costs-associated-with-the-management-of-non-infectious-intermediate-posterior-and-panuveitis-in-canada
#11
V Lambert-Obry, A Gouault-Laliberté, A Castonguay, M Aubin, J Vadboncoeur, M Laliberté, J Lachaine
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27956325/profile-of-patients-with-uveitis-referred-to-a-multidisciplinary-unit-in-northern-spain
#12
P Fanlo, H Heras, D Pérez, G Tiberio, G Espinosa, A Adan
OBJECTIVE: To describe the main characteristics of a cohort of patients with uveitis referred to a multidisciplinary unit in northern Spain. MATERIAL AND METHODS: Retrospective analysis of clinical records of patients evaluated in the Multidisciplinary Unit of the Navarra Hospital Complex from the period January 2010 until March 2015. An analysis was performed on the demographic characteristics, origin, types of uveitis, laterality, and aetiology. The present series was also compared with 2 previous series from Castilla y León and Barcelona...
December 7, 2016: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/27937033/epidemiology-of-uveitis-in-a-tertiary-care-referral-institute-in-north-india
#13
Mohit Dogra, Ramandeep Singh, Aniruddha Agarwal, Ashok Sharma, Simar Rajan Singh, Natasha Gautam, Sonam Yangzes, Ramanuj Samanta, Manu Sharma, Kanika Aggarwal, Aman Sharma, Kusum Sharma, Reema Bansal, Amod Gupta, Vishali Gupta
PURPOSE: To report epidemiology of uveitis in a tertiary-care referral institute in North India. METHODS: Hospital records of patients with uveitis between June 2011 and September 2014 were retrospectively analyzed. RESULTS: Of the 1912 patients, 56.64% were males. Anterior uveitis (43.04%) was the most common manifestation followed by posterior uveitis (24.58%), panuveitis (16.21%), and intermediate uveitis (10.66%). Specific etiologies could be ascertained in 60...
December 12, 2016: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/27932898/two-cases-of-vogt-koyanagi-harada-s-disease-in-sub-saharan-africa
#14
Tunji S Oluleye, Adekunle O Rotimi-Samuel, Adetunji Adenekan, Olubanke T Ilo, Folashade B Akinsola, Adeola O Onakoya, Olufisayo T Aribaba, Adebukunola Adefule-Ositelu, Kareem O Musa, Yele Oyefeso
Vogt-Koyanagi-Harada's (VKH) disease has been reported to be rare in sub-Saharan Africa. Two Nigerians with the disease are presented in this report. The first patient, a 32-year-old pregnant Nigerian woman presented with a 1-month history of bilateral blurring of vision, persistent headache, and alopecia. Presenting visual acuity was 1 m counting fingers in both eyes. Examination revealed vitiligo and poliosis with bilateral panuveitis as well as bilateral exudative retinal detachment. A clinical assessment of complete VKH disease was made...
2016: International Medical Case Reports Journal
https://www.readbyqxmd.com/read/27932857/vogt-koyanagi-harada-syndrome-current-perspectives
#15
REVIEW
Abeir Baltmr, Sue Lightman, Oren Tomkins-Netzer
Vogt-Koyanagi-Harada syndrome is a cause of noninfectious panuveitis, leading to significant vision loss in many patients. It is an autoimmune disease occurring in genetically susceptible individuals and clinically presents as bilateral panuveitis with serous retinal detachments and hyperemic, swollen optic discs, which are associated with neurological and auditory manifestations. Early diagnosis and prompt and adequate treatment with immunosuppressive agents (corticosteroids and other immunosuppressive drugs) may halt disease progression and prevent recurrences and vision loss...
2016: Clinical Ophthalmology
https://www.readbyqxmd.com/read/27929716/posttraumatic-endophthalmitis-in-children-epidemiology-diagnosis-management-and-prognosis
#16
Pooja Bansal, Pradeep Venkatesh, Yograj Sharma
Pediatric posttraumatic endophthalmitis presents with great complexities and challenges arising due to delayed presentation, difficulty in eliciting an accurate history, or trauma with unusual and highly contaminated objects. The possibility of initial misdiagnosis as panuveitis, metastatic endophthalmitis, and masquerade syndrome is also very high, which results not only in several unwarranted investigations being performed, but also a delay in the initiation of treatment. The standard treatment remains primary repair of the wound, intravitreal therapy with broad spectrum antibiotics, and parsplana vitrectomy...
December 8, 2016: Seminars in Ophthalmology
https://www.readbyqxmd.com/read/27927829/lesson-of-the-month-1-lobar-pulmonary-consolidation-in-an-immunocompromised-host
#17
Daniel J Reynolds, Carl A Andersen, Sumedh S Hoskote, Hee Eun Lee, Aditya Raghunathan, Sanjay Kalra, Andrew H Limper
A 19-year-old male with a history of idiopathic panuveitis, currently taking methotrexate and infliximab, presented to our institution with 6 weeks of cough, dyspnoea and fevers. He had failed outpatient antimicrobial therapy. Computerised tomography (CT) of the chest revealed the presence of a lobar pneumonia and he was treated with broad spectrum antibiotics, which did not improve his symptoms. Bronchoalveolar lavage was performed with a transbronchial lung biopsy because of the diagnostic uncertainty of the patient's presentation...
December 2016: Clinical Medicine: Journal of the Royal College of Physicians of London
https://www.readbyqxmd.com/read/27918224/ocular-autoimmune-systemic-inflammatory-infectious-study-oasis-report-1-epidemiology-and-classification
#18
Elizabeth J Chen, Muhammad Amir Bin Ismail, Helen Mi, Su Ling Ho, Wee Kiak Lim, Stephen C Teoh, Rupesh Agrawal
PURPOSE: To report the epidemiology and classification of ocular inflammation at a tertiary eye care center in Singapore. METHODS: Retrospective cohort study of the clinical records of consecutive new cases from the Ocular Autoimmune Systemic Inflammatory Infectious Study (OASIS) database from 2004-2015. RESULTS: A total of 2200 patients were studied from the OASIS database. The most common anatomic diagnosis was anterior uveitis (55.9%), posterior uveitis (17...
December 5, 2016: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/27914832/ophthalmic-manifestations-and-causes-of-vision-impairment-in-ebola-virus-disease-survivors-in-monrovia-liberia
#19
Jessica G Shantha, Ian Crozier, Brent R Hayek, Beau B Bruce, Catherine Gargu, Jerry Brown, John Fankhauser, Steven Yeh
PURPOSE: To describe the ocular findings, visual impairment, and association of structural complications of uveitis with visual impairment in a cohort of survivors of Ebola virus disease (EVD) in Monrovia, Liberia. DESIGN: Retrospective, uncontrolled, cross-sectional study. PARTICIPANTS: Survivors of EVD who were evaluated in an ophthalmology clinic at Eternal Love Winning Africa (ELWA) Hospital in Monrovia, Liberia. METHODS: A cohort of EVD survivors who underwent baseline ophthalmic evaluation at ELWA Hospital were retrospectively reviewed for demographic information, length of Ebola treatment unit (ETU) stay, visual acuity (VA), and ophthalmic examination findings...
February 2017: Ophthalmology
https://www.readbyqxmd.com/read/27904945/-sarcoidosis-and-uveitis-an-update
#20
REVIEW
J G Garweg
Ocular involvement in sarcoidosis is present in up to one third of patients and is frequently manifested before the underlying systemic disease has been diagnosed. With a view to the therapeutic consequences an early diagnosis of the underlying disease is advantageous. In cases of visual loss early diagnostic measures include invasive procedures, such as ultrasound-guided bronchoalveolar lavage and transbronchial biopsy, if nodular conjunctival or cutaneous manifestations which would confirm the diagnosis are not present...
November 30, 2016: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
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