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https://www.readbyqxmd.com/read/28429127/uveitis-in-siriraj-hospital-pattern-differences-between-immune-related-uveitis-and-infectious-uveitis-in-a-university-based-tertiary-care-hospital
#1
Nattaporn Tesavibul, Sutasinee Boonsopon, Pitipol Choopong, Sujintana Tanterdtham
PURPOSE: To describe a proportion of uveitis and to analyse differences between immune-related uveitis and infectious uveitis groups. METHODS: A retrospective study of 458 uveitis patients were categorized into immune-related uveitis, infectious uveitis, masquerade, and undetermined groups. The pattern of inflammation was described. Subgroup analysis was performed to compare pattern differences between immune-related uveitis and infectious uveitis groups. RESULTS: The most common location of inflammation was the anterior eye segment...
April 20, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28426849/effect-of-adalimumab-on-visual-functioning-in-patients-with-noninfectious-intermediate-uveitis-posterior-uveitis-and-panuveitis-in-the-visual-1-and-visual-2-trials
#2
John Sheppard, Avani Joshi, Keith A Betts, Stacie Hudgens, Samir Tari, Naijun Chen, Martha Skup, Andrew D Dick
Importance: Adalimumab was recently approved for the treatment of noninfectious intermediate uveitis, posterior uveitis, and panuveitis. Objective: To assess the effect of adalimumab on the visual functioning and quality of life in patients with corticosteroid-dependent noninfectious intermediate uveitis, posterior uveitis, and panuveitis. Design: A post hoc analysis of clinical trials of adults with active (VISUAL-1) and inactive (VISUAL-2) noninfectious intermediate uveitis, posterior uveitis, and panuveitis was conducted in the United States, Canada, Europe, Israel, Australia, Latin America, and Japan...
April 20, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28414043/quality-of-life-outcomes-from-a-randomized-clinical-trial-comparing-antimetabolites-for-intermediate-posterior-and-panuveitis
#3
Katherine M Niemeyer, John A Gonzales, Sivakumar R Rathinam, Manohar Babu, Radhika Thundikandy, Anuradha Kanakath, Travis C Porco, Erica N Browne, Maya M Rao, Nisha R Acharya
PURPOSE: To evaluate the changes in quality of life in noninfectious uveitis patients treated with two of the most commonly prescribed antimetabolite treatments. DESIGN: Secondary analysis of a multicenter, block-randomized, clinical trial (ClinicalTrials.gov NCT01232920). METHODS: Eighty patients at Aravind Eye Hospitals in Madurai and Coimbatore, India, with noninfectious intermediate, posterior, or panuveitis were randomized to receive oral methotrexate, 25 mg weekly, or oral mycophenolate mofetil, 1 g twice daily, and were followed up monthly for 6 months...
April 13, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28412807/-clinical-features-risk-factors-and-progresses-on-treatment-of-recurrent-vogt-koyanagi-harada-disease
#4
S S Jia, C Zhao, X S Liu, M F Zhang
Vogt-Koyanagi-Harada disease(VKH) is a bilateral, granulomatous panuveitis associated with central nervous system, auditory, and integumentary manifestations. Clinically, VKH usually responds well to early aggressive glucocorticosteroid treatment and may be cured without any clinically significant sequelae. Some patients, however, may enter the chronic recurrent phase, which may result in marked loss of vision due to complications such as complicated cataract, secondary glaucoma and maculopathy. Recurrent VKH is mainly characterized by anterior uveitis associated with thickening of the choroid...
April 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28399985/immunosuppressive-treatment-of-non-infectious-uveitis-history-and-current-choices
#5
Zhao Chan, Zhang Meifen
Non-infectious uveitis is one of the leading causes of preventable blindness worldwide. Long-term immunosuppressive treatment is generally required to achieve durable control of inflammation in posterior and panuveitis. Although systemic corticosteroids have been the gold standard of immunosup- pressive treatment for uveitis since first introduced in 1950s, its side effects of long-term use often warrant an adjuvant treatment to reduce the dosage/duration of corticosteroids needed to maintain disease control...
April 10, 2017: Chinese Medical Sciences Journal, Chung-kuo i Hsüeh K'o Hsüeh Tsa Chih
https://www.readbyqxmd.com/read/28396946/pattern-and-causes-of-visual-loss-in-beh%C3%A3-et-s-uveitis-short-term-and-long-term-outcomes
#6
Radgonde Amer, Walaa Alsughayyar, Diego Almeida
BACKGROUND: To analyze the pattern and causes of visual loss in patients with Behçet's uveitis and to report on the short-term outcome at 6 months and at last follow-up visit. Also, to analyze the pattern of visual acuity changes in eyes with and without macular involvement at the specified time points. METHODS: This is a retrospective cohort study of a single-center in an academic practice. Fifty-three patients with Behçet's uveitis evaluated between 2004 and 2014 were included...
April 10, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28394239/management-of-uveitis-and-scleritis-in-necrobiotic-xanthogranuloma
#7
John A Gonzales, Anna Haemel, Andrew J Gross, Nisha R Acharya
Necrobiotic xanthogranuloma (NXG) is a chronic, progressive non-Langerhans histiocytic granulomatous disease. While case reports describing periorbital involvement of NXG are frequent, only a few case reports describing ocular involvement, such as scleritis and uveitis, exist. Herein, we present a case presenting initially as bilateral anterior and posterior scleritis, as well as a chronic bilateral granulomatous panuveitis, and discuss the immunosuppressant options that should be considered for this disease with protean manifestations...
May 2017: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28366648/randomized-control-trial-evaluating-a-standardized-strategy-for-uveitis-etiological-diagnosis-ulisse
#8
Audrey de Parisot, Laurent Kodjikian, Marie-Hélène Errera, Neila Sedira, Emmanuel Heron, Laurent Pérard, Pierre-Loïc Cornut, Christelle Schneider, Sophie Rivière, Priscille Ollé, Grégory Pugnet, Pascal Cathébras, Pierre Manoli, Bahram Bodaghi, David Saadoun, Stéphanie Baillif, Nathalie Tieulie, Marc Andre, Frédéric Chiambaretta, Nicolas Bonin, Philip Bielefeld, Alain Bron, Frédéric Mouriaux, Boris Bienvenu, Stéphanie Vicente, Sylvie Bin, Christiane Broussolle, Evelyne Decullier, Pascal Sève
PURPOSE: To prospectively assess the efficiency of a standardized diagnostic approach, compared to an open strategy, for the etiological diagnosis of uveitis. DESIGN: Non-inferiority, prospective, multicenter, clustered randomized control trial. METHODS: Consecutive patients with uveitis, who visited one of the participating Departments of Ophthalmology, were included. In the standardized group, all patients had a minimal work-up regardless of the type of uveitis (complete blood count, erythrocyte sedimentation rate, C-reactive protein, tuberculin skin test, syphilis serology and chest X ray) followed by more complex investigations according to ophthalmological findings...
March 30, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28345954/chest-radiographic-screening-for-sarcoidosis-in-the-diagnosis-of-patients-with-active-uveitis
#9
Fahriye Groen, Jan A M van Laar, Aniki Rothova
RATIONALE: Although chest radiography is currently recommended for the initial evaluation of patients with new onset uveitis, the efficacy of this diagnostic screening modality is not known. OBJECTIVES: To evaluate the diagnostic value of chest radiographs in patients with active uveitis of recent onset in a tertiary center in Western Europe. METHODS: A retrospective cross-sectional study was conducted by reviewing all chest imaging for adults with new onset (<1 year) uveitis of unknown origin undergoing initial evaluation in the Department of Ophthalmology at Erasmus University Medical Center (Rotterdam, the Netherlands)...
March 27, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28323505/pattern-of-uveitis-in-a-referral-hospital-in-bangladesh
#10
Zahedur Rahman, Ziaul Ahsan, Niaz Abdur Rahman, Parthopratim Dutta Majumder
PURPOSE: To report the pattern of uveitis in a tertiary eye care center in Bangladesh. METHODS: Retrospective analysis of all uveitis cases visiting uveitis clinic of Bangladesh Eye Hospital between January, 2009 and April, 2015. RESULTS: In total, 652 patients (mean age 32.3 years, female 47.8%) were included in the study. Uveitis was bilateral in 42.6% of cases. Anterior uveitis was the most common (39.2%) case, closely followed by intermediate uveitis (22...
March 21, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/28318350/clinical-course-and-outcomes-of-pediatric-tubercular-uveitis-in-north-india
#11
Savleen Kaur, Kanika Aggarwal, Aniruddha Agarwal, Deepti Suri, Anju Gupta, Ramandeep Singh, Reema Bansal, Surjit Singh, Nirbhai Singh, Amod Gupta, Vishali Gupta
PURPOSE: To analyze the clinical features, course, management, and outcomes of tubercular (TB) uveitis in the pediatric population and assess the response to anti-tubercular therapy (ATT). METHODS: Hospital records of children (≤16 years) from a large tertiary-care institute between January 2001 and December 2015 were reviewed. RESULTS: A total of 32 children (mean age: 10.7 ± 4.27 years; range 2-16) were diagnosed with TB-associated uveitis...
March 20, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/28318342/pattern-of-uveitic-hypotony-in-a-tertiary-eye-hospital-in-india
#12
Parthopratim Dutta Majumder, Keerthi Burugupalli, Nitin Kumar Menia, Sudha K Ganesh, Jyotirmay Biswas
PURPOSE: To report pattern of uveitic patients with hypotony in Indian population. METHODS: Retrospective medical record review of 30 eyes of 21 consecutive patients with uveitic hypotony. Patient demographics, ocular findings and systemic association were recorded. RESULTS: Mean age of the patients was 29.5 years (range 7-71 years) and 80.9%(17 patients) were below the age of 40 years. Most common complaint associated with the development of hypotony was diminution of vision (26 eyes; 86...
March 20, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/28301414/ocular-toxicity-after-inadvertent-intracameral-injection-of-high-dose-of-cefuroxime-during-cataract-surgery-a-case-series
#13
Radua Kamal-Salah, Olayinka Osoba, Edward Doyle
PURPOSE: To report ocular side effects after inadvertent intracameral injection of a high dose of cefuroxime. METHODS: Nineteen eyes of 19 patients were seen in our eye department 1 week after the referring surgeon had injected an erroneous dose of intracameral cefuroxime (12.5 mg/0.1 mL in 14 patients, Group A, and 10 mg/0.1 mL in 5 patients, Group B) at the end of a cataract surgery. A complete ophthalmic examination was performed postoperatively. RESULTS: Eight patients (42...
March 15, 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/28293699/-lues-ocular-syphilis
#14
T Neß
Ocular syphilis is not a new issue but due to increasing rates of new cases is now a contemporary issue. The clinical features are unspecific and can be manifested as all forms of ocular inflammation. Unspecific anterior uveitis is the most frequent ocular involvement; however, typical distinctive patterns are superficial white preretinal precipitates within a panuveitis and acute syphilitic posterior placoid chorioretinitis. The diagnosis should be confirmed by serological tests. Treatment is based on parenteral administration of penicillin...
March 14, 2017: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/28257832/risk-factors-for-the-development-of-cataract-in-children-with-uveitis
#15
Tamar Blum-Hareuveni, Sophie Seguin-Greenstein, Michal Kramer, Guy Hareuveni, Yael Sharon, Ronit Friling, Lazha Sharief, Sue Lightman, Oren Tomkins-Netzer
PURPOSE: To determine the risk factors for the development of cataract in children with uveitis of any etiology. DESIGN: Cohort study METHODS: 247 eyes of 140 children with uveitis were evaluated for the development of vision affecting cataract. Demographic, clinical and treatment data were collected between the time of presentation and the first instance cataract was recorded or findings at final follow-up. Main outcome measures included prevalence of cataract and distribution by type of uveitis, incidence of new onset cataract time to cataract development and risk factors for the development of cataract...
February 28, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28253223/observation-and-clinical-pattern-in-patients-with-white-dot-syndromes-the-role-of-color-photography-in-monitoring-ocular-changes-in-long-term-observation
#16
Joanna Brydak-Godowska, Joanna Gołębiewska, Monika Turczyńska, Joanna Moneta-Wielgoś, Agnieszka Samsel, Piotr K Borkowski, Michał Ciszek, Agnieszka Płonecka-Rodzoch, Aleksandra Kużnik-Borkowska, Joanna Ciszewska, Elżbieta Makomaska-Szaroszyk, Lidia B Brydak, Dariusz Kęcik
BACKGROUND The aim of this study was to assess the clinical course and distinctive features of different white dot syndromes (WDS) in patients attending the Ophthalmology Department, Medical University of Warsaw in the years 1995-2015. MATERIAL AND METHODS Sixty-two (62) patients (43 females and 19 males), aged 18 to 77 years, referred with a WDS were included in this prospective study, with observation period ranging from 5 months to 16 years. All patients underwent a complete ophthalmological examination and multimodal imaging studies...
March 2, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28243891/igg4-related-disease-presenting-as-panuveitis-without-scleral-involvement
#17
REVIEW
Kinda Najem, Larissa Derzko-Dzulynsky, Edward A Margolin
BACKGROUND: The following case emphasizes the importance of including IgG4-related disease (RD) in the differential diagnosis of intraocular inflammation and multiple cranial nerve palsies. RESULTS: A 33-year-old man, with a history of idiopathic bilateral panuveitis, presented with a new right pupillary-sparing partial third nerve palsy, which spontaneously resolved in 2 weeks, but was followed 1 month later, by a right sixth nerve palsy, which also resolved within a few weeks...
December 2017: Journal of Ophthalmic Inflammation and Infection
https://www.readbyqxmd.com/read/28237149/enhanced-depth-imaging-optical-coherence-tomography-in-patients-with-different-phases-of-behcet-s-panuveitis
#18
Nilufer Yesilirmak, Wen-Hsiang Lee, Sirel Gur Gungor, Eylem Yaman Pinarci, Imren Akkoyun, Gursel Yilmaz
OBJECTIVE: To evaluate the changes in choroidal thickness (CT) at 13 different points between "active," "remission," and "end-stage" phase of Behcet's panuveitis and compare this with the age, sex, and spherical equivalent matched healthy controls using enhanced depth imaging optical coherence tomography. DESIGN: Prospective study. PARTICIPANTS: Eighty-five eyes of 45 patients with Behcet's panuveitis (19 eyes with active phase, 48 eyes with remission phase, and 18 eyes with end-stage phase) and 84 eyes of 42 controls were enrolled in this study...
February 2017: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/28229433/adalimumab-a-review-in-non-infectious-non-anterior-uveitis
#19
Sheridan M Hoy
Adalimumab (Humira(®)) is a tumour necrosis factor (TNF)-α inhibitor available in various countries worldwide, including the USA, Japan and those of the EU, for the treatment of non-infectious intermediate, posterior and panuveitis in adults. It is the first biological agent approved for this indication. In two multinational, phase III studies in adults with active and inactive disease, subcutaneous adalimumab significantly reduced the risk of treatment failure relative to placebo following the tapered withdrawal of corticosteroid therapy...
February 22, 2017: BioDrugs: Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy
https://www.readbyqxmd.com/read/28223848/severe-panuveitis-in-neuro-beh%C3%A3-et-s-disease-in-malaysia-a-case-series
#20
Khairuddin Othman, Ahmad Tajudin Liza-Sharmini, Mohtar Ibrahim, John Tharakan, Ryoji Yanai, Embong Zunaina
Behçet's disease (BD) is a multisystemic disease that is very rare in Malaysia. About 5% of patients develop central nervous system involvement, termed neuro-Behçet's. Neuro-Behçet's is one of the most serious causes of long-term morbidity and mortality. We report two cases of neuro-Behçet's associated with uveitis (ocular BD) highlighting the clinical presentation, diagnostic measurement, and therapeutic management of these cases.
2017: International Medical Case Reports Journal
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