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https://www.readbyqxmd.com/read/28579479/anti-obesogenic-and-hypolipidemic-effects-of-a-glucagon-like-peptide-1-receptor-agonist-derived-from-the-saliva-of-the-gila-monster
#1
Patricia Lucio Alves, Fernando Mauricio Francis Abdalla, Rafaela Fadoni Alponti, Paulo Flavio Silveira
INTRODUCTION: Glucagon-like peptide-1 (GLP-1) receptor (R) agonists are a class of incretin mimetic drugs that have been used for the treatment of type 2 diabetes mellitus and also considered strong candidates for the treatment of obesity. The original prototypical drug in this class is the exenatide, a synthetic peptide with the same structure as the native molecule, exendin-4, found in the saliva of the Gila monster (Heloderma suspectum suspectum lizard). OBJECTIVES: To identify and compare the anti-obesogenic, antidyslipidemic and antidiabetogenic effects of agonism in GLP-1R by exenatide on two distinct models of obesity: induced by hypothalamic injury (MSG) or high-calorie diet (DIO)...
June 1, 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/28511885/salivary-changes-in-type-2-diabetic-patients
#2
Sabah E Abd-Elraheem, Amany Mohammed El Saeed, Hayam Hamza Mansour
OBJECTIVE: this study was conducted to determine the effect of type 2 diabetes mellitus on salivary secretion of glucose, amylase and immunoglobulin A levels and also to fined out if saliva could be used as anon invasive method to monitor glycaemic control in type 2 diabbetes. This study was conducted on 40 human subjectes, They were 20 males and 20 females, their ages ranged from 35 years to 64 years,and they were divided into two groups, the first one is the patient group which contains 20 diabetic paient...
April 23, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/28453865/saliva-and-plasma-levels-of-cardiac-related-biomarkers-in-post-myocardial-infarction-patients
#3
Nilminie Rathnayake, Kåre Buhlin, Barbro Kjellström, Bjorn Klinge, Christian Löwbeer, Anna Norhammar, Lars Rydén, Timo Sorsa, Taina Tervahartiala, Anders Gustafsson
AIM: To relate cardiac biomarkers, such as cystatin C and growth differentiation factor-15 (GDF-15) in saliva to myocardial infarction (MI) and to periodontal status, and to investigate the relation between salivary and plasma cardiac biomarkers. MATERIALS AND METHODS: Two hundred patients with MI admitted to coronary care units and 200 matched controls without MI were included. Dental examination and collection of blood and saliva samples was performed 6-10 weeks after the MI for patients and in close proximity thereafter for controls...
April 28, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28321337/salivary-distinctiveness-and-modifications-in-males-with-diabetes-and-beh%C3%A3-et-s-disease
#4
Loai Aljerf, Iyad Alhaffar
Oral diseases associated with systematic diseases as metabolic and vasculitic have been included in this paper. This will enhance our understanding of the salivary function in promoting healthy oral condition. The study investigates the effects of type I and type II diabetes mellitus in well-controlled diabetic patients, in addition to Behçet disease (BD) on saliva flow rate (SFR), pH, the decay, missing, and filled tooth (DMFT) index, glucose, and major earth-alkaline ions (Ca(2+) and Mg(2+)) compared to healthy males and age-matched controls...
2017: Biochemistry Research International
https://www.readbyqxmd.com/read/28219814/biopsychosocial-pathways-linking-subjective-socioeconomic-disadvantage-to-glycemic-control-in-youths-with-type-i-diabetes
#5
Samuele Zilioli, Deborah A Ellis, Justin M Carré, Richard B Slatcher
Older adolescent and young adults (OAYA) with type 1 diabetes (T1D) living in contexts of socio-economic disadvantage (SED) suffer disproportionately from poor glycemic control and related health complications. Although SED may convey a variety of risks, it may exacerbate diabetes-related stress levels, which in turn may account for observed disparities in health outcomes. The primary goal of the present study was to investigate the relationship between subjective SED, diabetes-related perceived stress, and diurnal cortisol secretion in urban OAYA with T1D...
April 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/27893660/salivary-lactate-dehydrogenase-and-aminotransferases-in-diabetic-patients
#6
Barbara Malicka, Katarzyna Skoskiewicz-Malinowska, Urszula Kaczmarek
Diabetes mellitus (DM) is a group of metabolic diseases resulting from impaired insulin secretion and/or action. DM is characterized by hyperglycemia that can lead to the dysfunction or damage of organs, including the salivary glands.The aim of this study was to compare the levels of salivary lactate dehydrogenase (LDH), aspartate aminotransferase (AST), and alanine aminotransferase (ALT) in diabetic patients.The study was approved by the Bioethics Committee of Wroclaw Medical University (Poland). The study comprised 90 adults of both sexes, aged 21 to 57 years...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27664993/type-1-diabetes-in-children-is-not-a-predisposing-factor-for-oral-yeast-colonization
#7
Ana L Costa, Branca M A Silva, Rui Soares, Diana Mota, Vera Alves, Alice Mirante, João C Ramos, João Maló de Abreu, Manuel Santos-Rosa, Francisco Caramelo, Teresa Gonçalves
Type 1 diabetes mellitus (T1D) is considered a risk factor associated with oral yeast infections. The aim of this study was to evaluate the yeast oral carriage (in saliva and mucosal surface) of children with T1D and potential relation with host factors, particularly the subset of CD4+ T cells. Yeasts were quantified and identified in stimulated saliva and in cheek mucosal swabs of 133 diabetic T1D and 72 healthy control subjects. Salivary lymphocytes were quantified using flow cytometry. The presence of yeasts in the oral cavity (60% of total patients) was not affected by diabetes, metabolic control, duration of the disease, salivary flow rate or saliva buffer capacity, by age, sex, place of residence, number of daily meals, consumption of sweets or frequency of tooth brushing...
June 1, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/26779782/salivary-but-not-blood-cortisol-excretion-is-associated-with-metabolic-biomarkers-in-healthy-young-women
#8
Shoko Konishi, Kathleen A O'Connor
OBJECTIVES: Elevated and suppressed concentrations of cortisol have been linked with less favorable metabolic biomarkers, such as elevated lipids and glycosylated hemoglobin (HbA1c). Based on recent work reporting that some individuals secrete more cortisol into saliva (high saliva-to-blood cortisol ratio; high secretors) than others after correcting for blood cortisol concentrations, our objectives were to examine (1) whether lipids and glycosylated hemoglobin varied across cortisol and salivary secretor status; and (2) if blood and saliva provide the same results with respect to metabolic markers...
July 2016: American Journal of Human Biology: the Official Journal of the Human Biology Council
https://www.readbyqxmd.com/read/26629726/dried-saliva-spot-dss-as-a-convenient-and-reliable-sampling-for-bioanalysis-an-application-for-the-diagnosis-of-diabetes-mellitus
#9
Masahiro Numako, Takahiro Takayama, Ichiro Noge, Yutaka Kitagawa, Kenichiro Todoroki, Hajime Mizuno, Jun Zhe Min, Toshimasa Toyo'oka
This paper proposes the dried saliva spot (DSS) as a convenient sampling technique for bioanalysis. The analytical method with the DSS was used for the determination of D,L-lactic acid (D,L-LA) and the D/L ratio of diabetic patients and prediabetic persons for the simple screening of the disease. The D,L-LA in the DSS was labeled with a chiral reagent (DMT-3(S)-Apy) for carboxylic acids and determined by UPLC-ESI-MS/MS. The limits of detection (signal-to-noise ratio (S/N) = 3) for the DSS analysis were on the amol level (∼30 amol)...
January 5, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/26547140/effects-of-periodontal-treatment-on-inflammation-and-oxidative-stress-markers-in-patients-with-metabolic-syndrome
#10
G Torumtay, F Y Kırzıoğlu, M Öztürk Tonguç, B Kale, M Calapoğlu, H Orhan
BACKGROUND AND OBJECTIVE: Metabolic syndrome (MetS) is a combination of risk factors (e.g. impaired glucose tolerance, hypertension, and dyslipidaemia) that significantly contribute to the development of cardiovascular diseases. The aim of the study was to compare the effects of nonsurgical periodontal treatment (NSPT) on inflammatory and oxidative stress markers in individuals with MetS and systemically healthy (SH) who were chronic periodontitis (CP). MATERIAL AND METHODS: A total of 50 patients with chronic periodontitis (25 with MetS and 25 SH) were included...
August 2016: Journal of Periodontal Research
https://www.readbyqxmd.com/read/26094794/diabetes-mellitus-is-associated-with-low-secretion-rates-of-immunoglobulin-a-in-saliva
#11
Junko Oikawa, Shigekazu Ukawa, Hideki Ohira, Takashi Kawamura, Kenji Wakai, Masahiko Ando, Akira Hata, Akiko Tamakoshi
BACKGROUND: The association between diabetes mellitus (DM) and low secretory immunoglobulin A (s-IgA) secretion rates is one mechanism suspected of influencing susceptibility to infections among DM patients. However, several studies have shown contradictory results. We examined these two factors to seek evidence of an association among older people. METHODS: We analyzed a prospective cohort of 2306 subjects (1209 men and 1097 women) around 64 years old from the New Integrated Suburban Seniority Investigation (NISSIN) Project in Nisshin, Japan...
2015: Journal of Epidemiology
https://www.readbyqxmd.com/read/25915398/tumor-necrosis-factor-%C3%AE-matrix-metalloproteinases-8-and-9-levels-in-the-saliva-are-associated-with-increased-hemoglobin-a1c-in-type-1-diabetes-subjects
#12
Melanie N Kuehl, Henry Rodriguez, Brant R Burkhardt, Amy C Alman
BACKGROUND: Type 1 diabetes (T1D) is an autoimmune disease resulting in the targeted destruction of pancreatic β-cells and permanent loss of insulin production. Proper glucose management results in better clinical outcomes for T1D and provides a strong rationale to identify non-invasive biomarkers indicative or predictive of glycemic control. Therefore, we investigated the association of salivary inflammation with HbA1c in a T1D cohort. METHODS: Unstimulated saliva was collected from 144 subjects with T1D at the USF Diabetes Center...
2015: PloS One
https://www.readbyqxmd.com/read/25821337/%C3%AE-2-macroglobulin-in-saliva-is-associated-with-glycemic-control-in-patients-with-type-2-diabetes-mellitus
#13
Juan Pablo Aitken, Carolina Ortiz, Irene Morales-Bozo, Gonzalo Rojas-Alcayaga, Mauricio Baeza, Caroll Beltran, Alejandro Escobar
BACKGROUND: Subjects with type 2 diabetes mellitus (DM2) require an adequate glycemic control to avoid diabetic complications. Currently, saliva biomarkers are used as a diagnostic tool and can be indicative of the degree of progression and control of various diseases. Several studies indicate that α-2-macroglobulin levels are elevated in diabetic patients. METHODS: 120 subjects with DM2 were enrolled and classified into two groups according to their glycemic control (percentage of glycated hemoglobin-A1c (HbA1c), <7% adequate glycemic control group; >7% inadequate glycemic control group)...
2015: Disease Markers
https://www.readbyqxmd.com/read/25793156/secretion-of-salivary-statherin-is-compromised-in-uncontrolled-diabetic-patients
#14
Masahiro Izumi, Bin-Xian Zhang, David D Dean, Alan L Lin, Michèle J Saunders, Helen P Hazuda, Chih-Ko Yeh
BACKGROUND: Statherin is an important salivary protein for maintaining oral health. The purpose of the current study was to determine if differences in statherin levels exist between diabetic and healthy subjects. METHODS: A total of 48 diabetic and healthy controls were randomly selected from a community-based database. Diabetic subjects (n=24) had fasting glucose levels >180 mg/dL, while controls (n=24) had levels <110 mg/dL. Parotid saliva (PS) and sublingual/submandibular saliva (SS) were collected and salivary flow rates determined...
June 1, 2015: BBA Clinical
https://www.readbyqxmd.com/read/25747868/cohort-profile-the-mexican-american-mano-a-mano-cohort
#15
Wong-Ho Chow, Matthew Chrisman, Carrie R Daniel, Yuanqing Ye, Henry Gomez, Qiong Dong, Chelsea E Anderson, Shine Chang, Sara Strom, Hua Zhao, Xifeng Wu
Hispanic Americans comprise the largest and fastest-growing ethnic minority in the USA. In Houston, Texas, 44% of the population is of Hispanic descent, with the majority being Mexican Americans (78%). This population is under-represented in health-related research despite their high prevalence of obesity and diabetes, which may predispose them to cancer and other chronic conditions. Recognizing the need for a greater research effort into the health risks of Hispanic Americans, the population-based Mexican American (Mano a Mano) Cohort study was launched in 2001...
April 1, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/25672658/periodontal-status-and-whole-salivary-cytokine-profile-among-smokers-and-never-smokers-with-and-without-prediabetes
#16
COMPARATIVE STUDY
Fawad Javed, Abdulaziz A Al-Kheraif, Mohammad D Al Amri, Mohammed Alshehri, Fahim Vohra, Mansour Al-Askar, Hans Malmstrom, Georgios E Romanos
BACKGROUND: Whole salivary interleukin (IL)-1β and IL-6 in smokers and never-smokers with prediabetes remains uninvestigated. The aim of this study is to assess the periodontal status and whole salivary IL-1β and IL-6 levels among smokers and never-smokers with and without prediabetes (controls). METHODS: Ninety-five males (45 with prediabetes and 50 systemically healthy controls) were included. Twenty-seven controls and 29 patients with prediabetes were smokers...
July 2015: Journal of Periodontology
https://www.readbyqxmd.com/read/25527815/adenosine-deaminase-dipeptidyl-peptidase-iv-activities-and-lipid-peroxidation-are-increased-in-the-saliva-of-obese-young-adult
#17
Eduardo Ottobelli Chielle, Gabriela Bonfanti, Karine Santos De Bona, Rafael Noal Moresco, Maria Beatriz Moretto
BACKGROUND: Obesity is the hallmark of the metabolic syndrome representing a major global health problem. It is considered a state of chronic inflammation with minimal exploration of salivary biomarkers. Thus, the intent of the present study was to assess the activities of salivary dipeptidyl peptidase IV (DPP-IV), adenosine deaminase (ADA) and lipid peroxidation in obese young and overweight young subjects. METHODS: ADA, DPP-IV activities and lipid peroxidation were investigated in saliva, as well as insulin, glucose, HbA1c, HOMA and anthropometric measurements in 149 young adults, including 54 with normal weight, 27 overweight and 68 obese subjects...
June 2015: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/25327309/salivary-interleukin-17-and-tumor-necrosis-factor-%C3%AE-in-relation-to-periodontitis-and-glycemic-status-in-type-2-diabetes-mellitus
#18
Ulvi Kahraman Gürsoy, Sinem Yildiz Çiftlikli, Eija Könönen, Mervi Gürsoy, Başak Doğan
BACKGROUND: Poorly-controlled glycemic status in type 2 diabetes mellitus (T2DM) is suggested to play a role in the periodontal inflammatory process by aggregating the local cytokine response. Our objectives were to profile salivary interleukin (IL)-17 and tumor necrosis factor (TNF)-α levels in subjects with T2DM and to examine their relevance for the periodontal health status and glycemic control levels. METHODS: Unstimulated whole saliva samples, together with full-mouth periodontal recordings (plaque index [PI], bleeding on probing [BOP %], gingival index [GI], probing pocket depth [PPD], and clinical attachment level [CAL]), were collected from 123 subjects with T2DM...
September 2015: Journal of Diabetes
https://www.readbyqxmd.com/read/25305283/salivary-protein-glycosylation-as-a-noninvasive-biomarker-for-assessment-of-glycemia
#19
Paturi V Rao, Amber Laurie, Eric S Bean, Charles T Roberts, Srinivasa R Nagalla
Assessment of short-term glycemic control can facilitate monitoring of diabetes development in at-risk individuals and monitoring response to lifestyle modification or medication. We evaluated salivary protein glycosylation levels as a novel, noninvasive, short-term glycemic index in comparison to hemoglobin A1c (HbA1c), fructosamine, 1,5-anhydroglucitol (1,5-AG), and continuous glucose monitoring (CGM). Ten subjects with type 2 diabetes were monitored by CGM and saliva and blood were collected at baseline and days 1, 7, 14, 21, and 28 for determination of salivary protein glycosylation, serum fructosamine, and serum 1,5-anhydroglucitol (1,5-AG) levels, as well as HbA1c (baseline and day 28)...
January 2015: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/25294888/comparison-of-salivary-and-serum-glucose-levels-in-diabetic-patients
#20
COMPARATIVE STUDY
Shruti Gupta, Simarpreet Virk Sandhu, Himanta Bansal, Deepti Sharma
Diabetes mellitus is a noncommunicable disease with a rising prevalence worldwide and in developing countries. The most commonly used diagnostic biofluid for detection of glucose levels is blood, but sample collection is an invasive and painful procedure. Thus, there arises a need for a noninvasive and painless technique to detect glucose levels. The objectives of the present study were to estimate the glucose levels of saliva, to assess if any significant correlation existed between the serum and salivary glucose levels, and to correlate salivary glucose levels with regard to duration of diabetes, age, and gender...
January 2015: Journal of Diabetes Science and Technology
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