Mohamed J Saadh, Morug Salih Mahdi, Omer Qutaiba B Allela, Tuqa S Alazzawi, Mohammed Ubaid, Nodir M Rakhimov, Zainab H Athab, Pushpamala Ramaiah, Lathamangeswari Chinnasamy, Fahad Alsaikhan, Bagher Farhood
Activation of autophagy, a process of cellular stress response, leads to the breakdown of proteins, organelles, and other parts of the cell in lysosomes, and can be linked to several ailments, such as cancer, neurological diseases, and rare hereditary syndromes. Thus, its regulation is very carefully monitored. Transcriptional and post-translational mechanisms domestically or in whole organisms utilized to control the autophagic activity, have been heavily researched. In modern times, microRNAs (miRNAs) are being considered to have a part in post-translational orchestration of the autophagic activity, with miR-21 as one of the best studied miRNAs, it is often more than expressed in cancer cells...
March 30, 2024: Pathology, Research and Practice