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https://www.readbyqxmd.com/read/29679906/microrna-876-5p-inhibits-epithelial-mesenchymal-transition-and-metastasis-of-hepatocellular-carcinoma-by-targeting-bcl6-corepressor-like-1
#1
Qiuran Xu, Qiaojuan Zhu, Zhenyu Zhou, Yufeng Wang, Xin Liu, Guozhi Yin, Xiangmin Tong, Kangsheng Tu
Our previous study has reported that BCL6 corepressor like 1 (BCORL1) plays an oncogenic role in hepatocellular carcinoma (HCC) via promoting epithelial-mesenchymal transition (EMT) and tumor metastasis. However, the regulation of BCORL1 mediated by microRNAs (miRNAs) remains poorly known. The analysis of our clinical samples indicated that BCORL1 expression was markedly higher in HCC tissues than that in tumor-adjacent normal tissues. The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) datasets revealed that high BCORL1 expression associated with high tumor grade, advanced tumor stage and poor survival of HCC patients...
April 18, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29679904/tanshinone-iia-protects-murine-chondrogenic-atdc5-cells-from-lipopolysaccharide-induced-inflammatory-injury-by-down-regulating-microrna-203a
#2
Luan Luan, Zhiyuan Liang
BACKGROUND: Osteoarthritis is the most common bone-joint disease in middle and older people all over the world. Tanshinone IIA (Tan IIA) is the main lipophilic diterpenoid isolated from the root of Salvia miltiorrhiza Bunge (Lamiaceae). This study analyzed the protective effects of Tan IIA on lipopolysaccharide (LPS)-induced murine chondrogenic ATDC5 cell inflammatory injury model. METHODS: Cell viability was assessed using cell counting kit-8 (CCK-8) assay. Cell apoptosis was detected using Annexin V-FITC/PI staining...
April 18, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29679758/validation-and-bioinformatic-analysis-of-propofol-induced-differentially-expressed-micrornas-in-primary-cultured-neural-stem-cells
#3
Yan Li, Youtan Liu, Jun Fan, Quan Zhou, Xiuling Song, Zhiyong Peng, Zaisheng Qin, Tao Tao
Propofol, a widely used intravenous anesthetic, was previously considered as a neuroprotective agent. Recently, however, accumulating evidence suggests that it may cause neurotoxicity, especially in the development of neural stem cells (NSCs). The potential mechanisms contributing to propofol-induced neurotoxicity during neurogenesis, such as those involving microRNAs (miRNAs), are still unknown. In this study, a total of 27 differentially expressed miRNAs were identified in our initial screen and 6 miRNAs were validated by qRT-PCR...
April 18, 2018: Gene
https://www.readbyqxmd.com/read/29679755/long-non-coding-rna-xist-sponges-mir-34a-to-promotes-colon-cancer-progression-via-wnt-%C3%AE-catenin-signaling-pathway
#4
Ningning Sun, Guozun Zhang, Yingying Liu
Little is known about the role of long non-coding RNA XIST in the development of colon cancer. The aim of the present study was to investigate the levels of XIST in colon cancer, and explore its underlying mechanism. In this study, we found XIST expression level was upregulated in colon cancer tissues and cell lines. In addition, the growth rate of cells transfected with si-XIST was significantly decreased compared to that with si-NC, which was reversed by miR-34a targeted with 3'-UTR. Moreover, miR-34a suppressed the expression of WNT1 by binding with the 3'-UTR, which interact with WNT1 to inhibit the proliferation of cells...
April 18, 2018: Gene
https://www.readbyqxmd.com/read/29679673/glycogen-based-self-healing-hydrogels-with-ultra-stretchable-flexible-and-enhanced-mechanical-properties-via-sacrificial-bond-interactions
#5
Imtiaz Hussain, Sayed Mir Sayed, Shunli Liu, Olayinka Oderinde, Fang Yao, Guodong Fu
The development of hydrogel materials with enhanced mechanical properties is the primary focus in designing autonomous self-healable hydrogel materials. Here, we present a facile and cost-effective method for the autonomous self-healing hydrogel based on Glycogen (Gly/PAA-Fe3+ ) with enhanced mechanical properties by simple insertion of ferric ions in the physically cross-linked network via metal-ligand interactions. This dual physically cross-linked hydrogel has an excellent elongation at break and self-healing properties due to the dynamic ionic cross-linking point...
April 18, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29679644/non-viral-based-mir-delivery-and-recent-developments
#6
REVIEW
Annalise Elizabeth Labatut, George Mattheolabakis
miRNAs are promising therapeutic targets or tools for the treatment of numerous diseases, with most prominently, cancer. The inherent capacity of these short nucleic acids to regulate multiple cancer-related pathways simultaneously has prompted strong research on understanding miR functions and their potential use for therapeutic purposes. A key determinant of miR therapeutics' potential for treatment is their delivery. Viral and non-viral vectors attempt to address the major limitations associated with miR delivery, but several hurdles have been identified...
April 18, 2018: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29679626/microrna-expression-profile-in-plasma-from-type-1-diabetic-patients-case-control-study-and-bioinformatic-analysis
#7
Taís S Assmann, Mariana Recamonde-Mendoza, Márcia Puñales, Balduíno Tschiedel, Luís H Canani, Daisy Crispim
AIMS: To investigate a miRNA expression profile in plasma of type 1 diabetes (T1DM) patients and control subjects and analyze the putative pathways involved. METHODS: Expressions of 48 miRNAs were analyzed in plasma of 33 T1DM patients and 26 age-and-gender-matched controls using Stem-loop RT-PreAmp PCR and TaqMan Low Density Arrays (Thermo Fisher Scientific). Five dysregulated miRNAs were then chosen for validation in an independent sample of 27 T1DM patients and 14 controls, using RT-qPCR...
April 18, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29679612/protein-arginine-methyltransferase-5-promotes-lung-cancer-metastasis-via-the-epigenetic-regulation-of-mir-99-family-fgfr3-signaling
#8
Pengyu Jing, Nan Zhao, Mingxiang Ye, Yong Zhang, Zhipei Zhang, Jianyong Sun, Zhengxin Wang, Jian Zhang, Zhongping Gu
Protein arginine methyltransferase 5 (PRMT5) functions as a tumor initiator to regulate several cancer progressions, such as proliferation and apoptosis, by catalyzing the symmetrical dimethylation (me2s) of arginine residues within targeted molecules. However, the exact role of PRMT5-mediated metastasis in lung cancer is not fully understood. Here, we illustrated its potential effects in lung cancer metastasis in vivo and vitro. PRMT5 was frequently overexpressed in lung tumors, and its expression was positively related to tumor stages, lymphatic metastasis and poor outcome...
April 18, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29679565/activation-of-tlr3-and-its-adaptor-ticam-1-increases-mir-21-levels-in-extracellular-vesicles-released-from-human-cells
#9
Yoshimi Fukushima, Masaaki Okamoto, Kana Ishikawa, Takahisa Kouwaki, Hirotake Tsukamoto, Hiroyuki Oshiumi
Pattern-recognition receptors (PRRs) recognizes viral RNAs and trigger the innate immune responses. Toll-like receptor 3 (TLR3), a PRR, recognizes viral double-stranded RNA (dsRNA) in endolysosomes, whereas cytoplasmic dsRNA is sensed by another PRR, MDA5. TLR3 and MDA5 utilize TICAM-1 and MAVS, respectively, to trigger the signal for inducing innate immune responses. Extracellular vesicles (EVs) include the exosomes and microvesicles; an accumulating body of evidence has shown that EVs delivers functional RNA, such as microRNAs (miRNAs), to other cells and thus mediate intercellular communications...
April 18, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29678844/patients-with-unexplained-recurrent-spontaneous-abortion-show-decreased-levels-of-microrna-146a-5p-in-the-deciduae
#10
Liwei Zhao, Jian Li, Shiyun Huang
BACKGROUND: Immune intolerance of the fetal-placental unit may be a contributing cause of unexplained recurrent spontaneous abortion (URSA). OBJECTIVES: This study is to investigate the relevance of the miR-146a-5p/IFN-γ pathway to URSA. MATERIAL AND METHODS: Quantitative real-time RT-PCR and western blot were performed to compare the levels of miR-146a-5p, IFN-γ, IRAK1, and TRAF6 in the deciduae of URSA (n=29) and healthy women (n=35) after an elective abortion...
March 2018: Annals of Clinical and Laboratory Science
https://www.readbyqxmd.com/read/29678773/microrna-132-is-associated-with-the-cognition-improvement-following-voluntary-exercise-in-samp8-mice
#11
Jingde Dong, Yi Liu, Zhen Zhan, Xiaoshan Wang
The senescence-accelerated SAMP8 mouse is characterized by progressive cognitive decline and is considered to be a specific model of Alzheimer's disease (AD). A growing body of evidence indicates that physical exercise suppresses age-related cognitive decline. In the current study, we investigated the influence of voluntary wheel running on cognitive function in SAMP8 mice. We found that voluntary physical exercise ameliorated cognition decline and suppressed hippocampal neurodegeneration in SAMP8 mice. MicroRNA-132 (miR-132) is a short non-coding RNA which is enriched in the brain and is implicated in the regulation of neuronal activity and cognitive function...
April 17, 2018: Brain Research Bulletin
https://www.readbyqxmd.com/read/29678719/carnosic-acid-attenuates-cartilage-degeneration-through-induction-of-heme-oxygenase-1-in-human-articular-chondrocytes
#12
Hiroyuki Ishitobi, Yohei Sanada, Yoshio Kato, Yasunari Ikuta, Sachi Shibata, Satoshi Yamasaki, Martin K Lotz, Kiminori Matsubara, Shigeru Miyaki, Nobuo Adachi
Osteoarthritis (OA) is common age-associated disease, and associated with joint pain, mobility limitations and compromised overall quality of life. OA treatment is currently limited to pain management and joint arthroplasty at end stage disease. Oxidative damage to cartilage extracellular matrix and cells is an important mechanism in joint aging and OA pathogenesis. Evidence from in vitro and in vivo models of OA suggests that pharmaceuticals and natural compounds with antioxidant properties reduce expression of mediators of OA pathogenesis and OA severity in animal models...
April 17, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29678641/liver-directed-microrna-7a-depletion-induces-nonalcoholic-fatty-liver-disease-by-stabilizing-yy1-mediated-lipogenic-pathways-in-zebrafish
#13
Chi-Yu Lai, Chiu-Ya Lin, Chia-Chun Hsu, Kun-Yun Yeh, Guor Mour Her
Nonalcoholic fatty liver disease (NAFLD) has been associated with the function and changes in expression levels of microRNAs (miRs). MiR-7 has been proven to play an important role in many cellular processes; however, its functions in the context of liver lipogenesis remain unknown. We applied the microRNA-sponge (miR-SP) technology and generated transgenic miR-7a-SP models (hC7aSP and bC7aSP), which disrupted the activities of hepatic miR-7a and induced the early onset of NAFLD and nonalcoholic steatohepatitis (NASH) in zebrafish...
April 17, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29678584/genome-wide-profiles-of-metastasis-associated-mrnas-and-micrornas-in-salivary-adenoid-cystic-carcinoma
#14
Shubin Wang, Lei Zhang, Pengwei Shi, Yuanyuan Zhang, Hong Zhou, Xuanping Cao
Salivary adenoid cystic carcinoma (SACC) is often accompanied with poor prognosis due to local recurrence, distant metastasis, and perineural invasion. The mechanism involved in SACC metastasis is not yet fully understood. In this study, we profiled the expression of messenger RNA (mRNA) and microRNA (miRNA) in an SACC cell line, ACC-2, and a highly metastatic SACC cell line, ACC-M, using high-throughput sequencing. We discovered that: (1) differentially expressed (DE) mRNAs and DE miRNAs are potentially involved in SACC metastasis; (2) multiple regulatory interactions between DE miRNAs and DE mRNAs exist; and (3) miR-338-5p/3p target LAMC2 to impair motility and invasion of ACC-M and MDA-MB-231 cells...
April 17, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29678580/microrna-185-inhibits-the-growth-and-proliferation-of-osteoblasts-in-fracture-healing-by-targeting-pth-gene-through-down-regulating-wnt-%C3%AE-catenin-axis-in-an-animal-experiment
#15
Chang-Jiang Yao, Yang Lv, Cheng-Jun Zhang, Jia-Xin Jin, Li-Hu Xu, Jin Jiang, Bin Geng, Hong Li, Ya-Yi Xia, Meng Wu
Fracture healing is a repair process of a mechanical discontinuity loss of force transmission, and pathological mobility of bone. Increasing evidence suggests that microRNA (miRNA) could regulate chondrocyte, osteoblast, and osteoclast differentiation and function, indicating miRNA as key regulators of bone formation, resorption, remodeling, and repair. Hence, during this study, we established a right femur fracture mouse model to explore the effect microRNA-185 (miR-185) has on osteoblasts in mice during fracture healing and its underlying mechanism...
April 17, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29678578/circular-rna-circnasp-modulates-the-malignant-behaviors-in-osteosarcoma-via-mir-1253-foxf1-pathway
#16
Lipeng Huang, Mangmang Chen, Jun Pan, Weiyang Yu
Increasing evidences demonstrate that circular RNAs (circRNAs) serve as essential regulators in various human diseases, including cancer. However, the study on circRNA function in osteosarcoma (OS) is just emerging. In the present study, we screened out a novel circRNA termed circNASP which was significantly upregulated in OS tissues compared to adjacent normal tissues. We found that circNASP knockdown dramatically inhibited the proliferation, cell cycle progression and invasion of OS cells. Moreover, we showed that circNASP expression was positively correlated with tumor size and metastasis in OS patients...
April 17, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29678577/mir-485-5p-suppresses-breast-cancer-progression-and-chemosensitivity-by-targeting-survivin
#17
Meng Wang, Wen-Run Cai, Ran Meng, Jiang-Rui Chi, Yun-Rui Li, Ao-Xiang Chen, Yue Yu, Xu-Chen Cao
Breast cancer is the most common cancer among women worldwide. Chemoresistance remains to be a considerable obstacle in breast cancer therapy and it is often involves dysregulation of a variety of microRNAs (miRNAs). miR-485-5p functions as a tumor suppressor in several types of human cancers. However, its role in breast cancer chemosensitivity have not been determined. In the present study, we demonstrated that overexpression of miR-485-5p suppresses breast cancer progression and enhances chemosensitivity both in vitro and in vivo...
April 17, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29678573/long-non-protein-coding-rna-dancr-functions-as-a-competing-endogenous-rna-to-regulate-osteoarthritis-progression-via-mir-577-sphk2-axis
#18
Xiaochen Fan, Jishan Yuan, Jun Xie, Zhanpeng Pan, Xiang Yao, Xiangyi Sun, Pin Zhang, Lei Zhang
Long noncoding RNAs (lncRNAs) have been known to be involved in multiple diverse diseases, including osteoarthritis (OA). This study aimed to explore the role of differentiation antagonizing non-protein coding RNA (DANCR) in OA and identify the potential molecular mechanisms. The expression of DANCR in cartilage samples from patients with OA was detected using quantitative reverse transcription-polymerase chain reaction. The effects of DANCR on the viability of OA chondrocytes and apoptosis were explored using cell counting kit 8 assay and flow cytometry assay, respectively...
April 17, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29678219/lncrna-mnx1-as1-promotes-glioblastoma-progression-through-inhibition-of-mir-4443
#19
Yan Gao, Yongchuan Xu, Jue Wang, Xue Yang, Lulu Wen, Juan Feng
Long noncoding RNAs (lncRNAs) have been acknowledged as important regulators in various human cancers. LncRNA MNX1-AS1has been shown to be an oncogene in epithelial ovarian cancer. However, the function of MNX1-AS1 in glioblastoma (GBM) remains largely unknown. Here, we found that the expression of MNX1-AS1 was significantly upregulated in GBM tissues and cell lines. Knockdown of MNX1-AS1 significantly inhibited the proliferation, migration and invasion of GBM cells. In terms of mechanism, we found that MNX1-AS1 could bind to miR-4443 in GBM cells...
April 20, 2018: Oncology Research
https://www.readbyqxmd.com/read/29677903/re-mir-223-3p-regulates-cell-growth-and-apoptosis-via-fbxw7-suggesting-an-oncogenic-role-in-human-testicular-germ-cell-tumors
#20
Jerome P Richie
No abstract text is available yet for this article.
May 2018: Journal of Urology
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