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Connective tissue diseases

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https://www.readbyqxmd.com/read/29904913/mir-128-1-5p-regulates-tight-junction-induced-by-selenium-deficiency-via-targeting-cell-adhesion-molecule-1-in-broilers-vein-endothelial-cells
#1
Tingru Pan, Xueyuan Hu, Tianqi Liu, Zhe Xu, Na Wan, Yiming Zhang, Shu Li
Vein endothelial cells (VECs) constitute an important barrier for macromolecules and circulating cells from the blood to the tissues, stabilizing the colloid osmotic pressure of the blood, regulating the vascular tone, and rapidly changing the intercellular connection, and maintaining normal physiological function. Tight junction has been discovered as an important structural basis of intercellular connection and may play a key role in intercellular connection injuries or vascular diseases and selenium (Se) deficiency symptoms...
June 15, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29904459/unusual-presentation-of-spontaneous-coronary-artery-dissection-in-an-older-male
#2
Rajveer Joea, Sarah J Strube, Todd K Zynda
Spontaneous coronary artery dissection (SCAD) is a variant of acute coronary syndrome (ACS) that is poorly understood. SCAD has been linked to fibromuscular dysplasia (FMD), connective tissue disease (CTD), pregnancy and hormonal imbalance, systemic inflammatory conditions (e.g. IBD, vasculitis), and coronary artery vasospasm rather than traditional cardiac risk factors. Symptomology generally accompanying SCAD is indistinguishable from ACS making the timely recognition and diagnosis vital for prompt treatment...
June 2018: Cardiology Research
https://www.readbyqxmd.com/read/29901618/management-of-hepatic-vein-occlusive-disease-after-liver-transplantation-a-case-report-with-literature-review
#3
Yuchen Hou, Nga Lei Tam, Zhicheng Xue, Xuzhi Zhang, Bing Liao, Jie Yang, Shunjun Fu, Yi Ma, Linwei Wu, Xiaoshun He
RATIONALE: Hepatic vein occlusive disease (HVOD) is a rare complication after liver transplantation, which is characterized by nonthrombotic, fibrous obliteration of the small centrilobular hepatic veins by connective tissue and centrilobular necrosis in zone 3 of the acini. HVOD after solid organ transplantation has been reported; recently, most of these reports with limited cases have documented that acute cell rejection and immunosuppressive agents are the major causative factors. HVOD is relatively a rare complication of liver transplantation with the incidence of approximately 2%...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29901588/clinical-analysis-of-215-consecutive-cases-with-fever-of-unknown-origin-a-cohort-study
#4
Yong-Zhi Zhai, Xin Chen, Xin Liu, Zhi-Qiang Zhang, Hong-Ju Xiao, Gang Liu
Fever of unknown origin (FUO) is a frequently observed phenomenon in clinical practice. The present study was aimed to investigate potential causes of FUO, thereby improving clinical diagnosis of this disorder.In this retrospective study, clinical data were collected from 215 patients who were diagnosed with FUO between January 2009 and December 2010, and an 18 to 36 months follow-up visit was also performed for these patients.Among these FUO cases, the most common causes of the disease were infectious diseases (IDs) (42...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29901432/host-pathogen-interaction-reconstituted-in-3-dimensional-cocultures-of-mucosa-and-i-c-albicans-i
#5
Romina Buchs, Bruno Lehner, Phillippe Meuwly, Bruno Schnyder
<i>C. albicans</i> frequently causes recurrent intimal infectious disease (ID). This demands the treatment of multiple phases of the infection. The objective of this study was to uncover the host-pathogen-interaction using 2D epithelium cell-barrier and 3D subepithelium tissue cells of human mucosa. The 2D cell cultures assessed <i>C. albicans</i> adhesion. Addition of the anti-fungal drug Fluconazol did not inhibit the adhesion, despite its pathogen growth inhibition (MIC value 0.08μg/mL)...
June 14, 2018: Tissue Engineering. Part C, Methods
https://www.readbyqxmd.com/read/29901289/-the-role-of-structural-changes-of-the-urinary-bladder-extracellular-matrix-in-the-occurrence-of-different-grades-of-adverse-events-after-radiation-therapy
#6
O S Streltsova, V V Dudenkova, A V Maslennikova, E B Kiseleva, E A Tararova, K E Yunusova, L A Sinyakova
AIM: To investigate the role of structural changes of the urinary bladder extracellular matrix in the occurrence of different grades of adverse events after radiation therapy. MATERIALS AND METHODS: The connective tissue matrix was studied using 126 images obtained from the histological sections of the bladder biopsy specimens of 12 patients classified according to the clinical presentation and the grades of late bladder toxicity according to RTOG/EORTC Late Radiation Morbidity Scoring Scheme...
May 2018: Urologii︠a︡
https://www.readbyqxmd.com/read/29900295/peptidomics-dataset-blood-plasma-and-serum-samples-of-healthy-donors-fractionated-on-a-set-of-chromatography-sorbents
#7
Georgij Arapidi, Maria Osetrova, Olga Ivanova, Ivan Butenko, Tatjana Saveleva, Polina Pavlovich, Nikolay Anikanov, Vadim Ivanov, Vadim Govorun
Blood as connective tissue potentially contains evidence of all processes occurring within the organism, at least in trace amounts (Petricoin et al., 2006) [1]. Because of their small size, peptides penetrate cell membranes and epithelial barriers more freely than proteins. Among the peptides found in blood, there are both fragments of proteins secreted by various tissues and performing their function in plasma and receptor ligands: hormones, cytokines and mediators of cellular response (Anderson et al., 2002) [2]...
June 2018: Data in Brief
https://www.readbyqxmd.com/read/29899525/genome-wide-association-study-of-habitual-physical-activity-in-over-377-000-uk-biobank-participants-identifies-multiple-variants-including-cadm2-and-apoe
#8
Yann C Klimentidis, David A Raichlen, Jennifer Bea, David O Garcia, Nathan E Wineinger, Lawrence J Mandarino, Gene E Alexander, Zhao Chen, Scott B Going
BACKGROUND/OBJECTIVES: Physical activity (PA) protects against a wide range of diseases. Habitual PA appears to be heritable, motivating the search for specific genetic variants that may inform efforts to promote PA and target the best type of PA for each individual. SUBJECTS/METHODS: We used data from the UK Biobank to perform the largest genome-wide association study of PA to date, using three measures based on self-report (nmax  = 377,234) and two measures based on wrist-worn accelerometry data (nmax  = 91,084)...
June 13, 2018: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29898864/modern-treatment-to-reduce-pulmonary-arterial-pressure-in-pulmonary-arterial-hypertension
#9
REVIEW
Satoshi Akagi, Hiromi Matsubara, Kazufumi Nakamura, Hiroshi Ito
Treatment goals in pulmonary arterial hypertension (PAH) include improved quality of life and exercise capacity as well as improved life prognosis. In our experience, only remarkable reductions in pulmonary arterial pressure (PAP) improve long-term survival. Lowering PAP could contribute to reverse remodeling by reducing hemodynamic stress. Proper and prompt use of PAH-specific drugs lowers PAP in patients with PAH. Upfront combination therapy with different PAH-specific drugs and quickly establishing high-dose epoprostenol lowers PAP sufficiently to improve prognosis in patients with PAH...
June 10, 2018: Journal of Cardiology
https://www.readbyqxmd.com/read/29897157/could-quality-be-the-key-in-connective-tissue-disease-associated-interstitial-lung-disease
#10
EDITORIAL
Philip L Molyneaux, Toby M Maher
No abstract text is available yet for this article.
June 13, 2018: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/29895224/up-regulation-of-toll-like-receptors-7-and-9-and-its-potential-implications-in-the-pathogenic-mechanisms-of-lmna-related-myopathies
#11
Cristina Cappelletti, Franco Salerno, Eleonora Canioni, Marina Mora, Renato Mantegazza, Pia Bernasconi, Lorenzo Maggi
Laminopathies are a heterogeneous group of diseases with overlapping phenotypes that are caused by mutations in the nuclear envelope proteins lamin A and C. The most common group of laminopathies affects skeletal and cardiac muscle tissue, and is defined as LMNA-related myopathies (LMNA-RM). In LMNA-RM patients, muscle histological findings are very variable, ranging from mild and unspecific changes to dystrophic features, sometimes with inflammatory evidence. As recently demonstrated in Duchenne muscular dystrophy, we wondered whether in LMNA-RM muscle tissue the genetic defect might determine the activation of an innate immune response, mainly mediated by Toll-like receptors (TLRs), leading to a chronic inflammation and contributing to myofiber necrosis and fibrosis...
June 12, 2018: Nucleus
https://www.readbyqxmd.com/read/29892541/lymphocytic-interstitial-pneumonia-in-a-patient-with-mixed-connective-tissue-disease-a-case-report
#12
Chin-Wei Kuo, Kung-Chao Chang, Han-Yu Chang, Tang-Hsiu Huang
Lymphocytic interstitial pneumonia (LIP) is an uncommon interstitial lung disease that is characterized by an interstitial infiltrate of lymphoplasmacytic cells. While idiopathic LIP appears to be extremely rare, most reported cases of LIP have been associated with coexisting immune derangements, particularly autoimmune diseases such as Sjögren's syndrome. In this report, we describe the presentation of LIP in a patient with underlying mixed connective tissue disease.
2018: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/29891110/antinuclear-antibodies-and-cancer-a-literature-review
#13
REVIEW
Alexandru Vlagea, Sandra Falagan, Gerardo Gutiérrez-Gutiérrez, Juan Moreno-Rubio, María Merino, Francisco Zambrana, Enrique Casado, María Sereno
Antinuclear antibodies (ANAs) are a spectrum of autoantibodies targeted to various nuclear and cytoplasmic components of the cells. They are very useful as serological markers for different autoimmune disease, like systemic lupus erythematosus (SLE), Sjögren's syndrome (SS), scleroderma, polymyositis, or mixed connective tissue disease. In these years, an increasing attention has been focussed in the relationship between tumours and autoimmunity. Different authors have demonstrated that ANAs are presented, not only in autoimmune diseases, also in serum of patients with different types of cancers...
July 2018: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/29890445/evidence-of-aortic-dissection-and-marfan-syndrome-in-a-mummy-from-the-capuchin-catacombs-of-palermo-sicily
#14
Stephanie Panzer, Randall C Thompson, Klaus Hergan, Albert R Zink, Dario Piombino-Mascali
The authors report on the assessment of an anthropogenic mummy of a young man from the Capuchin Catacombs of Palermo, Sicily, tentatively dated from the mid- to late 19th century AD. The mummy was investigated by full-body CT examination. CT images clearly showed aortic dissection classified as Stanford-A. Due to the relation of aortic dissection to inherited connective tissue diseases in young people, such as Marfan syndrome, conspicuous and pathological findings possibly indicating the presence of underlying Marfan syndrome were assessed...
June 8, 2018: International Journal of Paleopathology
https://www.readbyqxmd.com/read/29889880/the-impact-of-comorbidity-on-mortality-in-danish-sarcoma-patients-from-2000-2013-a-nationwide-population-based-multicentre-study
#15
Mathias Raedkjaer, Katja Maretty-Kongstad, Thomas Baad-Hansen, Peter Holmberg Jørgensen, Akmal Safwat, Peter Vedsted, Michael Mørk Petersen, Thea Hovgaard, Tine Nymark, Johnny Keller
INTRODUCTION: Sarcoma is a rare type of cancer. The incidence increases with age and elderly patients may have comorbidity that affects the prognosis. The aim of this study was to describe the type and prevalence of comorbidity in a nationwide population-based study in Denmark from 2000-2013 and to analyse the impact of the different comorbidities on mortality. MATERIAL AND METHODS: The Danish Sarcoma Registry is a national clinical database containing all patients with sarcoma in the extremities or trunk wall from 2000 and onwards...
2018: PloS One
https://www.readbyqxmd.com/read/29887667/a-simulation-platform-using-3d-printed-neurovascular-phantoms-for-clinical-utility-evaluation-of-new-imaging-technologies
#16
S V Setlur Nagesh, J Hinaman, K Sommer, Z Xiong, C N Ionita, D R Bednarek, S Rudin
Modern 3D printing technology allows rapid prototyping of vascular phantoms based on an actual human patient with a high degree of precision. Using this technology, we present a platform to accurately simulate clinical views of neuro-endovascular interventions and devices. The neuro-endovascular interventional phantom has a 3D printed cerebrovasculature model derived from a patient CT angiogram and embedded inside a human skull providing bone attenuation. Acrylic layers were placed underneath and on top of the skull, simulating entrance and exit tissue attenuation and also simulating forward scatter...
February 2018: Proceedings of SPIE
https://www.readbyqxmd.com/read/29885537/impact-of-obesity-on-autoimmune-arthritis-and-its-cardiovascular-complications
#17
REVIEW
Katrien Van Raemdonck, Sadiq Umar, Zoltán Szekanecz, Ryan K Zomorrodi, Shiva Shahrara
Obesity can instigate and sustain a systemic low-grade inflammatory environment that can amplify autoimmune disorders and their associated comorbidities. Metabolic changes and inflammatory factors produced by the adipose tissue have been reported to aggravate autoimmunity and predispose the patient to cardiovascular disease (CVD) and metabolic comorbidities. Rheumatoid arthritis (RA) and psoriatic arthritis (PsA) are autoimmune arthritic diseases, often linked with altered body mass index (BMI). Severe joint inflammation and bone destruction have a debilitating impact on the patient's life; there is also a staggering risk of cardiovascular morbidity and mortality...
June 6, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/29883336/-clinical-and-serological-diversity-in-systemic-sclerosis
#18
Ewa Wielosz, Maria Majdan
Systemic sclerosis (SSc) is a multisystem connective tissue disease characterized by vascular damage with non-specific inflammation and progressive fibrosis. The disease exhibits a large heterogeneity in both clinical and serological features. This diversity refers to the course of the disease, which is difficult to predict in many cases. Although poor prognostic factors are well known, it is not always possible to predict the course of the disease and the prognosis. Furthermore, the activity of disease is difficult to assess since both reversible and irreversible lesions can occur in one patient...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29883331/-rheumatoid-arthritis-as-a-connective-tissue-disease
#19
Bożena Targońska-Stępniak
The available data indicate that seropositive rheumatoid arthritis (RA) develops as a result of systemic, autoimmune reaction directed against a range of "self" peptides/proteins that have undergone specific forms of post-translational modification. The development and progress of autoimmunity may be triggered by non-specific, local inflammatory processes outside the joints, for example in the oral or respiratory mucous membrane. The disease occurs in genetically susceptible individuals under the influence of environmental risk factors that promote autoimmunity and consequently the inflammatory process...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29883327/-musculoskeletal-symptoms-in-a-group-of-granulomatosis-with-polyangiitis-patients
#20
Radosław Jeleniewicz, Dorota Suszek, Maria Majdan
OBJECTIVE: Introduction: Musculoskeletal symptoms are not characteristic for granulomatosis with polyangiitis (GPA) patients. However, they could be present in two-thirds of patients at the onset of the disease and may provoke diagnostic difficulties. The aim: To assess retrospectively musculoskeletal manifestations in a group of GPA patients. PATIENTS AND METHODS: Material and methods: The analyzed group consisted of 44 patients with GPA (27M, 17F) aged 46.7 years (16-75) and treated at the Department of Rheumatology and Connective Tissue Diseases in Lublin between 2010-2016...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
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