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Endophthalmitis

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https://www.readbyqxmd.com/read/28801117/incidence-and-outcomes-of-infectious-and-noninfectious-endophthalmitis-after-intravitreal-injections-for-age-related-macular-degeneration
#1
Vincent Daien, Vuong Nguyen, Rohan W Essex, Nigel Morlet, Daniel Barthelmes, Mark C Gillies
PURPOSE: To assess the incidence, cumulative rate, and long-term outcomes of infectious and noninfectious endophthalmitis after intravitreal injections (IVTs) of anti-vascular endothelial growth factor (VEGF) agents. DESIGN: Database study, prospectively designed. PARTICIPANTS: Treatment-naïve eyes with neovascular age-related macular degeneration (nAMD) tracked by the Fight Retinal Blindness! (FRB!) registry that commenced anti-VEGF therapy between January 1, 2006, and November 30, 2016...
August 8, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28800650/peptide-nucleic-acid-fluorescence-in-situ-hybridization-for-detection-of-staphylococci-from-endophthalmitis-isolates-a-proof-of-concept-study
#2
Nimesh Patel, Darlene Miller, Nidhi Relhan, Harry W Flynn
Purpose: Rapid identification of pathogens causing endophthalmitis may improve treatment outcomes through early administration of species-specific medication. The current study reports a new molecular application of peptide nucleic acid-fluorescence in situ hybridization (PNA-FISH) with Staphylococcus-specific molecular PNA probes for the potential rapid detection of common pathogens causing endophthalmitis. Methods: An experimental study was designed to evaluate the proof of concept at the microbiology laboratory of the Bascom Palmer Eye Institute...
August 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28799557/the-application-of-an-acellular-dermal-allograft-alloderm-for-patients-with-insufficient-conjunctiva-during-evisceration-and-implantation-surgery
#3
S J Park, Y Kim, S Y Jang
PurposeTo describe the use of an acellular dermal allograft (AlloDerm) for patients with insufficient conjunctiva during evisceration and implantation surgery.Patients and methodsThe medical records of six patients with insufficient conjunctiva during evisceration surgery were reviewed. It was not possible to close the Tenon's capsule and conjunctiva without wound tension in these patients, so AlloDerm was placed over the sclera, and the edges were sutured with adjacent conjunctiva without tension. The size of the bare AlloDerm graft was measured in all patients...
August 11, 2017: Eye
https://www.readbyqxmd.com/read/28791473/59-eyes-with-endogenous-endophthalmitis-causes-outcomes-and-mortality-in-a-danish-population-between-2000-and-2016
#4
Søren Solborg Bjerrum, Morten la Cour
BACKGROUND: To study the epidemiology of patients with endogenous endophthalmitis in Denmark. MATERIAL AND METHODS: Retrospective and prospective case series of 59 eyes in patients with endogenous endophthalmitis in Denmark between 2000 and 2016. RESULTS: The age of the patients ranged from 28 to 90 years with a median of 66 years. Sixty-two percent of the eyes had a final VA (visual acuity) ≤ 0.1 while 8% had a final VA ≥ 1.0. Positive cultures were obtained in 51% of the cases from the blood and in 43% from the vitreous...
August 8, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28780782/endophthalmitis-prophylaxis-for-cataract-surgery
#5
Aravind Haripriya, Zervin R Baam, David F Chang
Endophthalmitis after cataract surgery is a rare but potentially devastating complication. There is great variability in endophthalmitis prophylaxis practice patterns worldwide. Treatment varies globally and is based on the microbiological profile and availability of formulations. Periocular povidone-iodine antisepsis is universally adopted and considered the standard of care in most practices. Perioperative topical antibiotics are also very popular despite the lack of level 1 evidence confirming efficacy. Based on growing observational evidence, routine intracameral antibiotic prophylaxis is increasing, especially where approved commercial intraocular preparations are available...
July 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/28774511/resident-performed-neodymium-yag-laser-posterior-capsulotomy
#6
Khalil Ghasemi Falavarjani, Mohammadreza Aghamirsalim, Kaveh Abri Aghdam
OBJECTIVE: To investigate the outcomes of resident-performed Nd:YAG laser posterior capsulotomy. DESIGN: Combined retrospective and prospective study. PARTICIPANTS: Patients (N = 301) who underwent Nd:YAG capsulotomy by ophthalmology residents at Rassoul Akram Hospital, Tehran, Iran. METHODS: Assessment of visual outcomes and complications and the results of second- and third-year residents. RESULTS: In the retrospective arm, 131 eyes of 129 patients were enrolled...
August 2017: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/28771946/prophylactic-intravitreal-antibiotics-reduce-the-risk-of-post-traumatic-endophthalmitis-after-repair-of-open-globe-injuries
#7
Marwan A Abouammoh, Abdullah Al-Mousa, Mohammad Gogandi, Hani Al-Mezaine, Essam Osman, Abdulrahman M Alsharidah, Abdullah Al-Kharashi, Ahmed M Abu El-Asrar
PURPOSE: To investigate efficacy of prophylactic intravitreal antibiotics in reducing incidence of endophthalmitis after repair of open globe injuries. At King Abdulaziz University Hospital, a standard protocol of intravenous vancomycin and ceftazidime was used in all cases. METHODS: Charts of 353 patients who presented between January 2010 and January 2014 with open globe injury were retrospectively reviewed. In addition, the standard protocol in this cohort included prophylactic intravitreal antibiotics in high-risk cases at time of primary repair...
August 3, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28769551/intravitreal-aflibercept-for-choroidal-neovascularization-associated-with-chorioretinitis-a-pilot-study
#8
Andrii R Korol, Oleksandra Zborovska, Taras Kustryn, Oleksandra Dorokhova, Nataliya Pasyechnikova
PURPOSE: The purpose of this study was to evaluate the potential benefits of intravitreal aflibercept injections for the treatment of choroidal neovascularization (CNV) secondary to chorioretinitis. METHODS: In this uncontrolled, prospective cohort study, 15 eyes of 14 consecutive patients affected by CNV associated with ocular toxoplasmosis were treated with intravitreal aflibercept (2 mg) pro re nata and observed over a 12-month follow-up period. The primary outcome was the change in best-corrected visual acuity (BCVA) from baseline to month 12...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28761565/first-reported-case-of-donor-related-candida-endophthalmitis-after-descemet-membrane-endothelial-keratoplasty
#9
Matthew Thompson, David Carli
PURPOSE: To report the first case of Candida donor to host transmission following descemet membrane endothelial keratoplasty (DMEK). METHODS: A retrospective case report. RESULTS: A patient underwent uneventful DMEK. Following surgery the donor rim was culture positive for Candida. The patient developed fungal endophthalmitis that was treated medically with multiple injections of voriconazole and amphotericin. Medical treatment was unable to clear the infection and removal of the donor material was required...
2017: Open Ophthalmology Journal
https://www.readbyqxmd.com/read/28761031/indications-for-enucleation-and-evisceration-in-a-tertiary-eye-hospital-in-riyadh-over-a-10-year-period
#10
Saad A Al-Dahmash, Sawsan Saad Bakry, Nada H Almadhi, Lolwah M Alashgar
BACKGROUND: Enucleation and evisceration are eye removal procedures considered as palliative treatment when all other therapeutic options are exhausted. OBJECTIVE: Describe the causes and histopathological findings leading to enucleation/evisceration, and correlate the clinical findings with the histopathological findings. DESIGN: Retrospective, descriptive study. SETTINGS: Tertiary care hospital, Riyadh, Saudi Arabia...
July 2017: Annals of Saudi Medicine
https://www.readbyqxmd.com/read/28757748/postoperative-herpetic-endophthalmitis-a-case-report
#11
Ya-Yun Yang, Yuan-Chieh Lee
We report a case of herpetic endophthalmitis following cataract surgery. A 65-year-old man underwent uneventful phacoemulsification and vision improved within the first few postoperative days. However, visual loss with an anterior chamber reaction of ++++ and a ++ vitreous cell were noted in the 4th postoperative week. Repeated intravitreal injection of vancomycin and ceftriaxone, pars plana vitrectomy and removal of the intraocular lens (IOL), and the capsular bag were performed sequentially but in vain. Bacterial, mycobacterial, and fungal culture of the IOL and capsular bag demonstrated negative findings...
October 2016: Ci Ji Yi Xue za Zhi, Tzu-chi Medical Journal
https://www.readbyqxmd.com/read/28757706/myopic-strabismus-fixus-with-endophthalmitis
#12
Taoufik Abdellaoui, Yassine Abaloune, Redouane Messaoudi, Fouad Elasri, Karim Reda, Abdelbarre Oubaaz
No abstract text is available yet for this article.
May 2017: Oman Journal of Ophthalmology
https://www.readbyqxmd.com/read/28752698/endophthalmitis
#13
REVIEW
Shwu Jiuan Sheu
Endophthalmitis is a rare but severe form of ocular inflammation due to infection of the intraocular cavity that can lead to irreversible visual loss if not treated properly and timely. It can be classified as exogenous or endogenous based on the transmission route of the infectious source. Exogenous endophthalmitis occurs when infecting organisms gain entry into the eye via direct inoculation, while endogenous endophthalmitis occurs when infectious agents hematogenously spread into the eye from a distant focus of infection...
August 2017: Korean Journal of Ophthalmology: KJO
https://www.readbyqxmd.com/read/28744092/using-maldi-tof-ms-to-test-staphylococcus-aureus-infected-vitreous
#14
Zhenyu Song, Xiuping Liu, Minyu Zhu, Yiwei Tan, Kaili Wu
PURPOSE: This study aimed to establish a method for testing Staphylococcus aureus in the vitreous of endophthalmitis with matrix-assisted laser desorption/ionization time of flight mass spectrometry (MALDI-TOF-MS), which is simple, fast, and sensitive. METHODS: S. aureus at different numbers was either mixed with homogenized vitreous or inoculated in porcine eyes for culturing, followed by homogenization. The homogenized vitreous samples, with or without centrifugation, were stained with Gram and Coomassie Blue (CBB) dyes and cultured with blood agar...
2017: Molecular Vision
https://www.readbyqxmd.com/read/28732619/endophthalmitis-prophylaxis-by-intracameral-antibiotics-in%C3%A2-vitro-model%C3%A2-comparing-vancomycin-cefuroxime-%C3%A2-and%C3%A2-moxifloxacin
#15
Peter E Libre, Sean Mathews
PURPOSE: To compare the efficacy of intracameral vancomycin, cefuroxime, and moxifloxacin on postoperative bacterial endophthalmitis rates. SETTING: Norwalk Hospital, Norwalk, Connecticut, USA. DESIGN: Experimental study. METHODS: Bacteria and intraocular lenses (IOLs) were incubated with vancomycin, cefuroxime, moxifloxacin, or combinations. Antibiotic concentrations were high, corresponding to clinical maximum intracameral doses (1...
June 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28728189/spontaneous-globe-rupture-due-to-rapidly-evolving-endogenous-hypermucoid-klebsiella-pneumoniae-endophthalmitis
#16
Edward H Wood, Matthew A Powers, Darius M Moshfeghi
In this retrospective report, the authors describe a rare case of spontaneous globe rupture from Klebsiella pneumoniae endophthalmitis in a middle-aged man with poorly controlled type 2 diabetes mellitus. There have been only four previously reported cases of spontaneous globe rupture from endophthalmitis. Out of the now five reported cases, all have been due to endogenous endophthalmitis, four have been due to gram-negative bacteria, and three have been due to K. pneumoniae. K. pneumoniae, especially the hypermucoid variant with a protective polysaccharide capsule, is an emerging pathogen with remarkable virulence...
July 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/28728182/endophthalmitis-and-concurrent-or-delayed-onset-rhegmatogenous-retinal-detachment-managed-with-pars-plana-vitrectomy-intravitreal-antibiotics-and-silicone-oil
#17
Vivek Pravin Dave, Avinash Pathengay, Nidhi Relhan, Pranjali Sharma, Subhadra Jalali, Rajeev Reddy Pappuru, Mudit Tyagi, Raja Narayanan, Jay Chhablani, Taraprasad Das, Harry W Flynn
BACKGROUND AND OBJECTIVE: The current study describes the treatment outcomes in patients with endophthalmitis and concurrent or delayed-onset retinal detachment managed with pars plana vitrectomy, intravitreal antibiotics, and silicone oil. PATIENTS AND METHODS: In this noncomparative, retrospective case series, the medical records of patients diagnosed with endophthalmitis and retinal detachment from January 1991 through December 2014 at a tertiary eye care center in South India were reviewed...
July 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/28724830/drug-resistant-coagulase-negative-staphylococcal-endophthalmitis-following-dexamethasone-intravitreal-implant
#18
Prabhushanker Mahalingam, Tasneem Tameem Topiwalla, Geetha Ganesan
A 60-year-old female came to our hospital with defective vision due to persistent diabetic macular edema and was treated with intravitreal ozurdex implant in the right eye. Three days later, the patient presented with diminution of vision, ocular pain, congestion, and hypopyon with no fundus view. B-scan ultrasonography showed vitritis, and diagnosis of endophthalmitis was made. Subsequently, 25-gauge pars plana vitrectomy was performed along with intravitreal vancomycin and amikacin and removal of implant...
July 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28724817/real-world-evidence-of-safety-profile-of-intravitreal-bevacizumab-avastin-in-an-indian-scenario
#19
Prashant Jain, Jay Sheth, Giridhar Anantharaman, Mahesh Gopalakrishnan
PURPOSE: The purpose of this study was to evaluate the safety profile of intravitreal bevacizumab (Avastin) as an off-label pharmacotherapeutic agent for various ocular conditions. METHODS: Retrospective analysis was carried out on 3806 injections of 1761 patients that were administered with intravitreal bevacizumab injection at a tertiary eye care center in India. The injections were administered on a pro re nata basis for various indications such as age-related macular degeneration (AMD), diabetic macular edema (DME), and retinal vein occlusion (RVO)...
July 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28724812/use-of-glycerol-preserved-corneas-for-corneal-transplants
#20
Neeti Gupta, Prerna Upadhyay
PURPOSE: This study was carried out to see the results of glycerol-preserved cornea (GPC) in emergency situation when fresh corneal tissue was not available. The aim was to study the outcome of corneal transplantation using GPC. METHODS: This was a retrospective study. The medical records of all the patients were reviewed, who underwent keratoplasty using "GPC" during the period from October 2011 to December 2015. The indication of keratoplasty, duration of preservation of the GPC, and its outcome were analyzed...
July 2017: Indian Journal of Ophthalmology
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