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animal model of temporal lobe epilepsy

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https://www.readbyqxmd.com/read/28237815/antiepileptic-action-of-c-jun-n-terminal-kinase-jnk-inhibition-in-an-animal-model-of-temporal-lobe-epilepsy
#1
Tina Y Tai, Lindsay N Warner, Terrance D Jones, Sangwook Jung, Francis A Concepcion, David W Skyrud, Jason Fender, Yusha Liu, Aaron D Williams, John F Neumaier, Raimondo D'Ambrosio, Nicholas P Poolos
Several phosphorylation signaling pathways have been implicated in the pathogenesis of epilepsy arising from both genetic causes and acquired insults to the brain. Identification of dysfunctional signaling pathways in epilepsy may provide novel targets for antiepileptic therapies. We previously described a deficit in phosphorylation signaling mediated by p38 mitogen-activated protein kinase (p38 MAPK) that occurs in an animal model of temporal lobe epilepsy, and that produces neuronal hyperexcitability measured in vitro...
February 22, 2017: Neuroscience
https://www.readbyqxmd.com/read/28235602/status-epilepticus-does-not-induce-acute-brain-inflammatory-response-in-the-amazon-rodent-proechimys-an-animal-model-resistant-to-epileptogenesis
#2
REVIEW
Carla A Scorza, Marcia J G Marques, Sérgio Gomes da Silva, Maria G Naffah-Mazzacoratti, Fulvio A Scorza, Esper A Cavalheiro
Mesial temporal lobe epilepsy is a serious brain disorder in adults that is often preceded by an initial brain insult, such as status epilepticus (SE), that after a latent period leads to recurrent seizures. Post-SE models are widely used for studies on epileptogenic processes. Previous findings of our laboratory suggested that the Neotropical rodents Proechimys exhibit endogenous antiepileptogenic mechanisms in post-SE models. Strong body of research supports that SE triggers a rapid and dramatic upregulation of inflammatory mediators and vascular endothelial growth factor (VEGF)...
February 21, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28226825/effect-of-temperature-on-sleep-regulation-in-an-animal-epilepsy-model
#3
Asmaa Ajwad, Farid Yaghouby, Dillon Huffman, Bruce O'Hara, Sridhar Sunderam, Asmaa Ajwad, Farid Yaghouby, Dillon Huffman, Bruce O'Hara, Sridhar Sunderam, Dillon Huffman, Farid Yaghouby, Asmaa Ajwad, Bruce O'Hara, Sridhar Sunderam
Besides recurring seizures, disordered sleep is common in individuals with epilepsy and may present as reduced sleep depth, altered proportions of different stages of sleep, intermittent arousal, and other phenomena. Sleep loss can in turn precipitate seizures, thus sustaining a vicious cycle. It is well known that changes in ambient temperature elicit thermoregulatory responses that alter the dynamics of sleep. As a first step toward therapeutic sleep modulation for epilepsy, we assessed the effect of elevated ambient temperature on sleep dynamics and seizure yield in the chronic pilocarpine mouse model of temporal lobe epilepsy...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28218241/massively-augmented-hippocampal-dentate-granule-cell-activation-accompanies-epilepsy-development
#4
Christopher G Dengler, Cuiyong Yue, Hajime Takano, Douglas A Coulter
In a mouse model of temporal lobe epilepsy, multicellular calcium imaging revealed that disease emergence was accompanied by massive amplification in the normally sparse, afferent stimulation-induced activation of hippocampal dentate granule cells. Patch recordings demonstrated reductions in local inhibitory function within the dentate gyrus at time points where sparse activation was compromised. Mimicking changes in inhibitory synaptic function and transmembrane chloride regulation was sufficient to elicit the dentate gyrus circuit collapse evident during epilepsy development...
February 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28188855/auditory-processing-assessment-suggests-that-wistar-audiogenic-rat-neural-networks-are-prone-to-entrainment
#5
Hyorrana Priscila Pereira Pinto, Vinícius Rezende Carvalho, Daniel de Castro Medeiros, Ana Flávia Santos Almeida, Eduardo Mazoni Andrade Marçal Mendes, Marcio Flávio Dutra Moraes
Epilepsy is a neurological disease related to the occurrence of pathological oscillatory activity, but the basic physiological mechanisms of seizure remain to be understood. Our working hypothesis is that specific sensory processing circuits may present abnormally enhanced predisposition for coordinated firing in the dysfunctional brain. Such facilitated entrainment could share a similar mechanistic process as those expediting the propagation of epileptiform activity throughout the brain. To test this hypothesis, we employed the Wistar audiogenic rat (WAR) reflex animal model, which is characterized by having seizures triggered reliably by sound...
February 7, 2017: Neuroscience
https://www.readbyqxmd.com/read/28157273/a-novel-animal-model-of-acquired-human-temporal-lobe-epilepsy-based-on-the-simultaneous-administration-of-kainic-acid-and-lorazepam
#6
Friederike Kienzler-Norwood, Lara Costard, Chinmaya Sadangi, Philipp Müller, Valentin Neubert, Sebastian Bauer, Felix Rosenow, Braxton A Norwood
OBJECTIVE: Kainic acid (KA) is a potent glutamate analog that is used to induce neurodegeneration and model temporal lobe epilepsy (TLE) in rodents. KA reliably induces severe, prolonged seizures, that is, convulsive status epilepticus (cSE), which is typically fatal without pharmacologic intervention. Although the use of KA to model human epilepsy has proven unquestionably valuable for >30 years, significant variability and mortality continue to confound results. These issues are probably the consequence of cSE, an all-or-nothing response that is inherently capricious and uncontrollable...
February 2017: Epilepsia
https://www.readbyqxmd.com/read/28088683/effects-of-protease-activated-receptor-1-inhibition-on-anxiety-and-fear-following-status-epilepticus
#7
Ruslan Bogovyk, Oleksii Lunko, Mihail Fedoriuk, Dmytro Isaev, Oleg Krishtal, Gregory L Holmes, Elena Isaeva
Protease-activated receptor 1 (PAR1) is an important contributor to the pathogenesis of a variety of brain disorders associated with a risk of epilepsy development. Using the lithium-pilocarpine model of temporal lobe epilepsy (TLE), we recently showed that inhibition of this receptor during the first ten days after pilocarpine-induced status epilepticus (SE) results in substantial anti-epileptogenic and neuroprotective effects. As PAR1 is expressed in the central nervous system regions of importance for processing emotional reactions, including amygdala and hippocampus, and TLE is frequently associated with a chronic alteration of the functions of these regions, we tested the hypothesis that PAR1 inhibition could modulate emotionally driven behavioral responses of rats experiencing SE...
February 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28079889/deletion-of-the-bh3-only-protein-noxa-alters-electrographic-seizures-but-does-not-protect-against-hippocampal-damage-after-status-epilepticus-in-mice
#8
Naoki Ichikawa, Mariana Alves, Shona Pfeiffer, Elena Langa, Yasmina E Hernández-Santana, Hidenori Suzuki, Jochen Hm Prehn, Tobias Engel, David C Henshall
Several members of the Bcl-2 gene family are dysregulated in human temporal lobe epilepsy and animal studies show that genetic deletion of some of these proteins influence electrographic seizure responses to chemoconvulsants and associated brain damage. The BH3-only proteins form a subgroup comprising direct activators of Bax-Bak that are potently proapoptotic and a number of weaker proapoptotic BH3-only proteins that act as sensitizers by neutralization of antiapoptotic Bcl-2 family members. Noxa was originally characterized as a weaker proapoptotic, 'sensitizer' BH3-only protein, although recent evidence suggests it too may be potently proapoptotic...
January 12, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28062187/dentate-gyrus-autonomous-ictal-activity-in-the-status-epilepticus-rat-model-of-epilepsy
#9
Florian Weissinger, Matthias Wawra, Pawel Fidzinski, Mark Elsner, Hartmut Meierkord, Martin Holtkamp, Katharina Buchheim
The dentate gyrus (DG) as part of the hippocampal formation is believed to serve as a gatekeeper with strong inhibitory properties against uncontrolled propagation of neuronal activity from the entorhinal cortex and neocortical structures. In temporal lobe epilepsy, the DG becomes hyperexcitable and loses its gate function, enabling propagation of ictal activity into downstream structures such as CA3 and CA1 areas. Furthermore, the DG, apart from facilitating propagation, may also be able to autonomously generate ictal activity, but this point has remained open so far...
January 3, 2017: Brain Research
https://www.readbyqxmd.com/read/28053048/identifying-new-antiepileptic-drugs-through-genomics-based-drug-repurposing
#10
Nasir Mirza, Greame J Sills, Munir Pirmohamed, Anthony G Marson
Currently available antiepileptic drugs (AEDs) fail to control seizures in 30% of patients. Genomics-based drug repurposing (GBR) offers the potential of savings in the time and cost of developing new AEDs. In the current study, we used published data and software to identify the transcriptomic signature of chornic temporal lobe epilepsy and the drugs that reverse it. After filtering out compounds based on exclusion criteria, such as toxicity, 36 drugs were retained. 11 of the 36 drugs identified (>30%) have published evidence of the antiepileptic efficacy (for example, curcumin) or antiepileptogenic affect (for example, atorvastatin) in recognised rodent models or patients...
January 4, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28050361/effects-of-swimming-exercise-on-learning-and-memory-in-the-kainate-lesion-model-of-temporal-lobe-epilepsy
#11
Vasavi Rakesh Gorantla, Sudhakar Pemminati, Vernon Bond, Dewey G Meyers, Richard Mark Millis
INTRODUCTION: An aerobic exercise (Ex) augments neurogenesis and may ameliorate learning and memory deficits in the rat Kainic Acid (KA) model of temporal lobe epilepsy in the short-term but whether it reverses learning and memory deficits after a substantial period of delay remains unclear. AIM: This study tests the hypothesis that aerobic Ex attenuates the learning and memory deficits associated with kainate seizures in the long-term. MATERIALS AND METHODS: A total of 60 rats were subjected to chemical lesioning using KA and to an Ex intervention consisting of a 30 days period of daily swimming for 15 min, immediately after KA lesioning (immediate exposure) or after a 60 days period of normal activity (delayed exposure)...
November 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28017648/non-invasive-pet-imaging-of-brain-inflammation-at-disease-onset-predicts-spontaneous-recurrent-seizures-and-reflects-comorbidities
#12
Daniele Bertoglio, Jeroen Verhaeghe, Eva Santermans, Halima Amhaoul, Elisabeth Jonckers, Leonie Wyffels, Annemie Van Der Linden, Niel Hens, Steven Staelens, Stefanie Dedeurwaerdere
Brain inflammation is an important factor in the conversion of a healthy brain into an epileptic one, a phenomenon known as epileptogenesis, offering a new entry point for prognostic tools. The development of anti-epileptogenic therapies to treat before or at disease onset is hampered by our inability to predict the severity of the disease outcome. In a rat model of temporal lobe epilepsy we aimed to assess whether in vivo non-invasive imaging of brain inflammation at disease onset was predictive of spontaneous recurrent seizures (SRS) frequency and severity of depression-like and sensorimotor-related comorbidities...
December 23, 2016: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/27965619/dynamic-changes-in-spectral-and-spatial-signatures-of-high-frequency-oscillations-in-rat-hippocampi-during-epileptogenesis-in-acute-and-chronic-stages
#13
Pan-Pan Song, Jing Xiang, Li Jiang, Heng-Sheng Chen, Ben-Ke Liu, Yue Hu
OBJECTIVE: To analyze spectral and spatial signatures of high frequency oscillations (HFOs), which include ripples and fast ripples (FRs, >200 Hz) by quantitatively assessing average and peak spectral power in a rat model of different stages of epileptogenesis. METHODS: The lithium-pilocarpine model of temporal lobe epilepsy was used. The acute phase of epilepsy was assessed by recording intracranial electroencephalography (EEG) activity for 1 day after status epilepticus (SE)...
2016: Frontiers in Neurology
https://www.readbyqxmd.com/read/27956120/intraperitoneal-injection-of-il-4-ifn-%C3%AE-modulates-the-proportions-of-microglial-phenotypes-and-improves-epilepsy-outcomes-in-a-pilocarpine-model-of-acquired-epilepsy
#14
Tianyi Li, Xuan Zhai, Jinqiu Jiang, Xiaojie Song, Wei Han, Jiannan Ma, Lingling Xie, Li Cheng, Hengsheng Chen, Li Jiang
Recent studies have reported microglia that are activated in the central nervous system (CNS) in patients with temporal lobe epilepsy and animal models of epilepsy. However, limited data are available on the dynamic changes of the proportions of various phenotypes of microglia throughout epileptogenesis and whether IL-4/IFN-γ administration can modulate the proportions of microglial phenotypes to affect the outcome of epilepsy. The current study examined this issue using a mouse model of pilocarpine-induced epilepsy...
December 9, 2016: Brain Research
https://www.readbyqxmd.com/read/27932302/hippocampal-asymmetry-differences-in-the-left-and-right-hippocampus-proteome-in-the-rat-model-of-temporal-lobe-epilepsy
#15
Leila Sadeghi, Albert Anatolyevich Rizvanov, Ilnur Ildusovich Salafutdinov, Bahareh Dabirmanesh, Mohammad Sayyah, Yaghoub Fathollahi, Khosro Khajeh
: The hippocampus is a complex brain structure and undergoes severe sclerosis and gliosis in temporal lobe epilepsy (TLE) as the most common type of epilepsy. The key features of the TLE may be reported in chronic animal models of epilepsy, such as pilocarpine model. Therefore, the current study was conducted in a rat pilocarpine model of acquired epilepsy. Two-dimensional gel electrophoresis based proteomic technique was used to compare the proteome map of the left and right hippocampus in both control and epileptic rats...
February 10, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/27905510/remarkable-alterations-of-nav1-6-in-reactive-astrogliosis-during-epileptogenesis
#16
Hongyan Zhu, Yuxiao Zhao, Hao Wu, Nan Jiang, Ziyi Wang, Weide Lin, Jiahui Jin, Yonghua Ji
Voltage-gated sodium channels (VGSCs) play a vital role in controlling neuronal excitability. Nav1.6 is the most abundantly expressed VGSCs subtype in the adult central nervous system and has been found to contribute to facilitate the hyperexcitability of neurons after electrical induction of status epilepticus (SE). To clarify the exact expression patterns of Nav1.6 during epileptogenesis, we examined the expression of Nav1.6 at protein and mRNA levels in two distinct animal models of temporal lobe epilepsy (TLE) including a post-SE model induced by kainic acid (KA) intrahippocampal injection and a kindling model evoked by pentylenetetrazole (PTZ)...
December 1, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27865173/accelerated-cognitive-decline-in-a-rodent-model-for-temporal-lobe-epilepsy
#17
Sandra Schipper, Marlien W Aalbers, Kim Rijkers, Melanie Lagiere, Jan G Bogaarts, Arjan Blokland, Sylvia Klinkenberg, Govert Hoogland, Johan S H Vles
OBJECTIVE: Cognitive impairment is frequently observed in patients with temporal lobe epilepsy. It is hypothesized that cumulative seizure exposure causes accelerated cognitive decline in patients with epilepsy. We investigated the influence of seizure frequency on cognitive decline in a rodent model for temporal lobe epilepsy. METHODS: Neurobehavioral assessment was performed before and after surgery, after the induction of self-sustaining limbic status epilepticus (SSLSE), and in the chronic phase in which rats experienced recurrent seizures...
December 2016: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/27847463/metabolic-therapy-for-temporal-lobe-epilepsy-in-a-dish-investigating-mechanisms-of-ketogenic-diet-using-electrophysiological-recordings-in-hippocampal-slices
#18
REVIEW
Masahito Jr Kawamura, David N Ruskin, Susan A Masino
The hippocampus is prone to epileptic seizures and is a key brain region and experimental platform for investigating mechanisms associated with the abnormal neuronal excitability that characterizes a seizure. Accordingly, the hippocampal slice is a common in vitro model to study treatments that may prevent or reduce seizure activity. The ketogenic diet is a metabolic therapy used to treat epilepsy in adults and children for nearly 100 years; it can reduce or eliminate even severe or refractory seizures. New insights into its underlying mechanisms have been revealed by diverse types of electrophysiological recordings in hippocampal slices...
2016: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/27814647/role-of-jnk-isoforms-in-the-kainic-acid-experimental-model-of-epilepsy-and-neurodegeneration
#19
Carme Auladell, Luisa de Lemos, Ester Verdaguer, Miren Ettcheto, Oriol Busquets, Alberto Lazarowski, Carlos Beas-Zarate, Jordi Olloquequi, Jaume Folch, Antoni Camins
Chemoconvulsants that induce status epilepticus in rodents have been widely used over the past decades due to their capacity to reproduce with high similarity neuropathological and electroencephalographic features observed in patients with temporal lobe epilepsy (TLE). Kainic acid  is one of the most used chemoconvulsants in experimental models. KA administration mainly induces neuronal loss in the hippocampus. We focused the present review inthe c-Jun N-terminal kinase-signaling pathway (JNK), since it has been shown to play a key role in the process of neuronal death following KA activation...
January 1, 2017: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/27746231/tracking-recurrence-of-correlation-structure-in-neuronal-recordings
#20
Samuel A Neymotin, Zoe N Talbot, Jeeyune Q Jung, André A Fenton, William W Lytton
BACKGROUND: Correlated neuronal activity in the brain is hypothesized to contribute to information representation, and is important for gauging brain dynamics in health and disease. Due to high dimensional neural datasets, it is difficult to study temporal variations in correlation structure. NEW METHOD: We developed a multiscale method, Population Coordination (PCo), to assess neural population structure in multiunit single neuron ensemble and multi-site local field potential (LFP) recordings...
January 1, 2017: Journal of Neuroscience Methods
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