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animal model of temporal lobe epilepsy

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https://www.readbyqxmd.com/read/28521116/efficacy-of-anticonvulsant-substances-in-the-6hz-seizure-test-comparison-of-two-rodent-species
#1
Elise Esneault, Guillaume Peyon, Vincent Castagné
Usually performed in the mouse, the 6Hz seizure test is used for screening potential new anticonvulsant substances against complex partial seizures. Nevertheless, advanced models of temporal lobe epilepsy (TLE) are more often performed in rats, so that possible species-related differences may complicate the development of anticonvulsant substances. The aim of the present study was to evaluate the feasibility of adapting the 6Hz test in the rat. We first compared the effects of increasing current intensities for inducing seizures in the mouse and in the rat...
May 10, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/28506440/the-wistar-audiogenic-rat-war-strain-and-its-contributions-to-epileptology-and-related-comorbidities-history-and-perspectives
#2
Norberto Garcia-Cairasco, Eduardo H L Umeoka, José A Cortes de Oliveira
In the context of modeling epilepsy and neuropsychiatric comorbidities, we review the Wistar Audiogenic Rat (WAR), first introduced to the neuroscience international community more than 25years ago. The WAR strain is a genetically selected reflex model susceptible to audiogenic seizures (AS), acutely mimicking brainstem-dependent tonic-clonic seizures and chronically (by audiogenic kindling), temporal lobe epilepsy (TLE). Seminal neuroethological, electrophysiological, cellular, and molecular protocols support the WAR strain as a suitable and reliable animal model to study the complexity and emergent functions typical of epileptogenic networks...
May 11, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28501694/4-4-diisothiocyanatostilbene-2-2-disulfonic-acid-attenuates-spontaneous-recurrent-seizures-and-vasogenic-edema-following-lithium-pilocarpine-induced-status-epilepticus
#3
Tingting Yang, Zhenzhou Lin, Ling Xie, Yao Wang, Suyue Pan
Vasogenic edema induced by blood brain barrier disruption and neuronal loss play an important role in the epileptogenic process. 4,4'- diisothiocyanatostilbene-2,2'-disulfonic acid (DIDS) is a commonly used anion channel inhibitor that has been reported to exert an anticonvulsant effect in rat hippocampus in vitro. The present study aimed to investigate whether DIDS could prevent epileptogenic process in rat lithium-pilocarpine model of temporal lobe epilepsy. The tight junction proteins and serum extravasation were examined in the piriform cortex 3days after status epilepticus...
May 10, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28446201/anticonvulsant-effects-of-antiaris-toxicaria-aqueous-extract-investigation-using-animal-models-of-temporal-lobe-epilepsy
#4
Priscilla Kolibea Mante, Donatus Wewura Adongo, Eric Woode
BACKGROUND: Antiaris toxicaria has previously shown anticonvulsant activity in acute animal models of epilepsy. The aqueous extract (AAE) was further investigated for activity in kindling with pentylenetetrazole and administration of pilocarpine and kainic acid which mimic temporal lobe epilepsy in various animal species. RESULTS: ICR mice and Sprague-Dawley rats were pre-treated with AAE (200-800 mg kg(-1)) and convulsive episodes induced using pentylenetetrazole, pilocarpine and kainic acid...
April 26, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28444637/phase-dependent-astroglial-alterations-in-li-pilocarpine-induced-status-epilepticus-in-young-rats
#5
Adriana Fernanda K Vizuete, Matheus Mittmann Hennemann, Carlos Alberto Gonçalves, Diogo Losch de Oliveira
Epilepsy prevalence is high in infancy and in the elderly population. Lithium-pilocarpine is widely used to induce experimental animal models of epilepsy, leading to similar neurochemical and morphological alterations to those observed in temporal lobe epilepsy. As astrocytes have been implicated in epileptic disorders, we hypothesized that specific astroglial changes accompany and contribute to epileptogenesis. Herein, we evaluated time-dependent astroglial alterations in the hippocampus of young (27-day-old) rats at 1, 14 and 56 days after Li-pilocarpine-induced status epilepticus (SE), corresponding to different phases in this model of epilepsy...
April 25, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28436627/-temporal-lobe-epilepsy-and-adult-hippocampal-neurogenesis
#6
Liying Chen, Yi Wang, Zhong Chen
Temporal lobe epilepsy (TLE) is a common and severe neurological disorder which is often intractable. It can not only damage the normal structure and function of hippocampus, but also affect the neurogenesis in dentate gyrus (DG). It is well documented from researches on the animal models of TLE that after a latent period of several days, prolonged seizure activity leads to a dramatic increase in mitotic activity in the hippocampal DG. However, cell proliferation returns to baseline levels within 3-4 weeks after status epilepticus (SE)...
January 25, 2017: Zhejiang da Xue Xue Bao. Yi Xue Ban, Journal of Zhejiang University. Medical Sciences
https://www.readbyqxmd.com/read/28436625/-effects-of-crocin-on-hippocampus-rapid-kindling-epilepsy-in-mice
#7
Xiting Wang, Oufeng Tang, Yilu Ye, Mingzhi Zheng, Jue Hu, Zhong Chen, Kai Zhong
Objective: To investigate the effect of crocin on the progression and generalized seizure of temporal lobe epilepsy in mice. Methods: Hippocampus rapid kindling model was established in C57BL/6J mice. The effects of crocin on seizure stage, afterdischarge duration (ADD), number of stimulation in each stage and final state, the incidence of generalized seizure (GS), average seizure stage and ADD were observed. Results: Crocin (20 mg/kg) significantly retarded behavioral seizure stages ( P<0.05) and shortened cumulative ADD ( P<0...
January 25, 2017: Zhejiang da Xue Xue Bao. Yi Xue Ban, Journal of Zhejiang University. Medical Sciences
https://www.readbyqxmd.com/read/28432779/nmdar-independent-hippocampal-long-term-depression-impairment-after-status-epilepticus-in-a-lithium-pilocarpine-model-of-temporal-lobe-epilepsy
#8
Andrey D Ivanov, Aleksey V Zaitsev
Temporal lobe epilepsy is usually associated with cognitive decline and memory deficits. Despite numerous existing studies on various animal models, the mechanisms of these deficits remain largely unclear. A specific form of long-term synaptic efficacy changes - long-term depression (LTD) - is thought to play an important role in memory formation and learning. However, extremely little is known about the possible alteration of LTD induction and dynamics after a status epilepticus (SE). In the present work we investigated the acute and delayed effects of lithium-pilocarpine-induced SE on NMDAR-dependent and NMDAR-independent hippocampal LTD in vitro...
April 22, 2017: Synapse
https://www.readbyqxmd.com/read/28416442/allopregnanolone-decreases-interictal-spiking-and-fast-ripples-in-an-animal-model-of-mesial-temporal-lobe-epilepsy
#9
Maxime Lévesque, Rochelle Herrington, Leila Leclerc, Michael A Rogawski, Massimo Avoli
The objective of this study was to characterize the impact of allopregnanolone, a neurosteroid that acts as a positive allosteric modulator of synaptic and extrasynaptic GABAA receptors, on interictal spikes and high-frequency oscillations (ripples: 80-200 Hz, fast ripples: 250-500 Hz) in the pilocarpine model of mesial temporal lobe epilepsy. Seven out of 25 Sprague-Dawley rats experiencing 1 h of pilocarpine-induced status epilepticus (SE) began treatment with allopregnanolone (9.6-12.8 mg/kg/day) on the following day...
April 15, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28393712/therapeutic-role-of-synaptic-vesicle-glycoprotein-2a-sv2a-in-modulating-epileptogenesis
#10
Yukihiro Ohno, Kentaro Tokudome
Dysfunction of synaptic neurotransmitter release is closely involved in the pathogenesis of various central nervous system diseases. Synaptic vesicle glycoprotein 2A (SV2A) is a membrane protein specifically expressed in synaptic vesicles and it modulates action potential-dependent neurotransmitter release in the brain. Since 1) SV2A-knockout mice exhibit severe convulsive seizures, 2) SV2A expression in the brain is reportedly altered in various epileptic disorders both in animal models (e.g., kindling and genetic models) and humans (e...
April 4, 2017: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/28390940/ginkgo-biloba-l-attenuates-spontaneous-recurrent-seizures-and-associated-neurological-conditions-in-lithium-pilocarpine-rat-model-of-temporal-lobe-epilepsy-through-inhibition-of-mammalian-target-of-rapamycin-pathway-hyperactivation
#11
Arindam Ghosh Mazumder, Pallavi Sharma, Vikram Patial, Damanpreet Singh
ETHNOPHARMACOLOGICAL RELEVANCE: Ginkgo biloba L. (Ginkgoaceae) has been widely used in traditional medicine for variety of neurological conditions particularly behavioral and memory impairments. AIM OF THE STUDY: The present study was envisaged to explore the effect of a standardized fraction of Ginkgo biloba leaves (GBbf) in rat model of lithium-pilocarpine induced spontaneous recurrent seizures, and associated behavioral impairments and cognitive deficit. MATERIALS AND METHODS: Rats showing appearance of spontaneous recurrent seizures following lithium pilocarpine (LiPc)-induced status epilepticus (SE) were treated with different doses of GBbf or vehicle for subsequent 4 weeks...
May 23, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28382749/feline-temporal-lobe-epilepsy-review-of-the-experimental-literature
#12
REVIEW
S Kitz, J G Thalhammer, U Glantschnigg, M Wrzosek, A Klang, P Halasz, M N Shouse, A Pakozdy
Accumulating evidence suggests that epileptic seizures originating from the temporal lobe (TL) occur in cats. Typically, affected animals have clinically focal seizures with orofacial automatisms including salivation, facial twitching, lip smacking, chewing, licking, and swallowing. Motor arrest and autonomic and behavioral signs also may occur. Many affected cats have magnetic resonance imaging (MRI) changes within the hippocampus or histopathologically confirmed hippocampal sclerosis or necrosis. From the 1950s to the 1980s, cats frequently were used as animal models for neurophysiological experiments and electrophysiological studies, from which important basic knowledge about epilepsy originated, but which has been rarely cited in clinical veterinary studies...
May 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28378878/network-evolution-in-mesial-temporal-lobe-epilepsy-revealed-by-diffusion-tensor-imaging
#13
Helen Wang, Yuegao Huang, Daniel Coman, Reshma Munbodh, Roni Dhaher, Hitten P Zaveri, Fahmeed Hyder, Tore Eid
OBJECTIVE: The objective of the present study is to identify novel, time-indexed imaging biomarkers of epileptogenesis in mesial temporal lobe epilepsy (MTLE). METHODS: We used high-resolution brain diffusion tensor imaging (DTI) of the translationally relevant methionine sulfoximine (MSO) brain infusion model of MTLE. MSO inhibits astroglial glutamine synthetase, which is deficient in the epileptogenic hippocampal formation of patients with MTLE. MSO-infused (epileptogenic) rats were compared with phosphate-buffered saline (PBS)-infused (nonepileptogenic) rats at early (3-4 days) and late (6-9 weeks) time points during epileptogenesis...
May 2017: Epilepsia
https://www.readbyqxmd.com/read/28268645/effect-of-temperature-on-sleep-regulation-in-an-animal-epilepsy-model
#14
Asmaa Ajwad, Farid Yaghouby, Dillon Huffman, Bruce O'Hara, Sridhar Sunderam
Besides recurring seizures, disordered sleep is common in individuals with epilepsy and may present as reduced sleep depth, altered proportions of different stages of sleep, intermittent arousal, and other phenomena. Sleep loss can in turn precipitate seizures, thus sustaining a vicious cycle. It is well known that changes in ambient temperature elicit thermoregulatory responses that alter the dynamics of sleep. As a first step toward therapeutic sleep modulation for epilepsy, we assessed the effect of elevated ambient temperature on sleep dynamics and seizure yield in the chronic pilocarpine mouse model of temporal lobe epilepsy...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28242958/intranasal-delivery-of-mir-146a-mimics-delayed-seizure-onset-in-the-lithium-pilocarpine-mouse-model
#15
Hua Tao, Jianghao Zhao, Tingting Liu, Yujie Cai, Xu Zhou, Huaijie Xing, Yan Wang, Mingkang Yin, Wangtao Zhong, Zhou Liu, Keshen Li, Bin Zhao, Haihong Zhou, Lili Cui
Unveiling the key mechanism of temporal lobe epilepsy (TLE) for the development of novel treatments is of increasing interest, and anti-inflammatory miR-146a is now considered a promising molecular target for TLE. In the current study, a C57BL/6 TLE mouse model was established using the lithium-pilocarpine protocol. The seizure degree was evaluated according to the Racine scale, and level 5 was considered the threshold for generalized convulsions. Animals were sacrificed to analyze the hippocampus at three time points (2 h and 4 and 8 weeks after pilocarpine administration to evaluate the acute, latent, and chronic phases, resp...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28237815/antiepileptic-action-of-c-jun-n-terminal-kinase-jnk-inhibition-in-an-animal-model-of-temporal-lobe-epilepsy
#16
Tina Y Tai, Lindsay N Warner, Terrance D Jones, Sangwook Jung, Francis A Concepcion, David W Skyrud, Jason Fender, Yusha Liu, Aaron D Williams, John F Neumaier, Raimondo D'Ambrosio, Nicholas P Poolos
Several phosphorylation signaling pathways have been implicated in the pathogenesis of epilepsy arising from both genetic causes and acquired insults to the brain. Identification of dysfunctional signaling pathways in epilepsy may provide novel targets for antiepileptic therapies. We previously described a deficit in phosphorylation signaling mediated by p38 mitogen-activated protein kinase (p38 MAPK) that occurs in an animal model of temporal lobe epilepsy, and that produces neuronal hyperexcitability measured in vitro...
May 4, 2017: Neuroscience
https://www.readbyqxmd.com/read/28235602/status-epilepticus-does-not-induce-acute-brain-inflammatory-response-in-the-amazon-rodent-proechimys-an-animal-model-resistant-to-epileptogenesis
#17
REVIEW
Carla A Scorza, Marcia J G Marques, Sérgio Gomes da Silva, Maria da Graça Naffah-Mazzacoratti, Fulvio A Scorza, Esper A Cavalheiro
Mesial temporal lobe epilepsy is a serious brain disorder in adults that is often preceded by an initial brain insult, such as status epilepticus (SE), that after a latent period leads to recurrent seizures. Post-SE models are widely used for studies on epileptogenic processes. Previous findings of our laboratory suggested that the Neotropical rodents Proechimys exhibit endogenous antiepileptogenic mechanisms in post-SE models. Strong body of research supports that SE triggers a rapid and dramatic upregulation of inflammatory mediators and vascular endothelial growth factor (VEGF)...
February 22, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28226825/effect-of-temperature-on-sleep-regulation-in-an-animal-epilepsy-model
#18
Asmaa Ajwad, Farid Yaghouby, Dillon Huffman, Bruce O'Hara, Sridhar Sunderam, Asmaa Ajwad, Farid Yaghouby, Dillon Huffman, Bruce O'Hara, Sridhar Sunderam, Dillon Huffman, Farid Yaghouby, Asmaa Ajwad, Bruce O'Hara, Sridhar Sunderam
Besides recurring seizures, disordered sleep is common in individuals with epilepsy and may present as reduced sleep depth, altered proportions of different stages of sleep, intermittent arousal, and other phenomena. Sleep loss can in turn precipitate seizures, thus sustaining a vicious cycle. It is well known that changes in ambient temperature elicit thermoregulatory responses that alter the dynamics of sleep. As a first step toward therapeutic sleep modulation for epilepsy, we assessed the effect of elevated ambient temperature on sleep dynamics and seizure yield in the chronic pilocarpine mouse model of temporal lobe epilepsy...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28218241/massively-augmented-hippocampal-dentate-granule-cell-activation-accompanies-epilepsy-development
#19
Christopher G Dengler, Cuiyong Yue, Hajime Takano, Douglas A Coulter
In a mouse model of temporal lobe epilepsy, multicellular calcium imaging revealed that disease emergence was accompanied by massive amplification in the normally sparse, afferent stimulation-induced activation of hippocampal dentate granule cells. Patch recordings demonstrated reductions in local inhibitory function within the dentate gyrus at time points where sparse activation was compromised. Mimicking changes in inhibitory synaptic function and transmembrane chloride regulation was sufficient to elicit the dentate gyrus circuit collapse evident during epilepsy development...
February 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28188855/auditory-processing-assessment-suggests-that-wistar-audiogenic-rat-neural-networks-are-prone-to-entrainment
#20
Hyorrana Priscila Pereira Pinto, Vinícius Rezende Carvalho, Daniel de Castro Medeiros, Ana Flávia Santos Almeida, Eduardo Mazoni Andrade Marçal Mendes, Márcio Flávio Dutra Moraes
Epilepsy is a neurological disease related to the occurrence of pathological oscillatory activity, but the basic physiological mechanisms of seizure remain to be understood. Our working hypothesis is that specific sensory processing circuits may present abnormally enhanced predisposition for coordinated firing in the dysfunctional brain. Such facilitated entrainment could share a similar mechanistic process as those expediting the propagation of epileptiform activity throughout the brain. To test this hypothesis, we employed the Wistar audiogenic rat (WAR) reflex animal model, which is characterized by having seizures triggered reliably by sound...
April 7, 2017: Neuroscience
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