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https://www.readbyqxmd.com/read/29166752/immunotherapy-treatment-an-issue-for-metabolic-response
#1
Luca Tagliabue, Antonella Capozza, Claudio Maioli, Andrea Luciani, Anna M Ierardi, Gianpaolo Carrafiello
Since the beginning of second decade of this century, when it was introduced in many oncologic scenarios, immunotherapy has become an important tool in the management of a growing number of cancers. Engaging the host immune system in cancer therapy seems to be useful, improving not only progression free survival but also overall survival, until the achieving the goal that many advanced cancers, previously considered without effective treatment options, have now become successfully treatable. Moreover, considering the relatively recent introduction of these drugs in clinical scenarios and the continuous releasing of new drugs, large validated clinical experiences are lacking and many issues are today debated; by the way, the evaluation of the response to immune-therapy poses major concerns...
November 22, 2017: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29166738/-expression-characteristics-and-prognosis-significance-of-mirna-181a-in-acute-myeloid-leukemia-with-normal-karyotype
#2
X X Zhuang, Q L Ma, H P Wang, M X Yu, X Li, H T Meng, W J Yu, C J Jin, L S You, J Jin
Objective: To study the expression of miRNA-181a in acute myeloid leukemia (AML) patients with normal karyotype to probe its prognosis significance. Methods: The expression level of miRNA-181a in bone marrow mononuclear cells of 120 de novo AML patients with normal karyotype was detected by real time fluorescence quantitative PCR. The direct sequencing method was used to detect IDH1, IDH2, NPM1, FLT3-ITD, DNMT3A and CEBPα mutations in CN-AML patients after PCR. The relationship between miRNA-181a expression and gene mutation, the clinical parameters and prognosis were analyzed...
October 14, 2017: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
https://www.readbyqxmd.com/read/29166737/-clinical-analysis-of-patients-with-hemophagocytic-lymphohistiocytosis-complicated-with-gastrointestinal-bleeding
#3
Z L Jin, Y N Wang, Z Wang
Objective: To explore the clinical features of patients with hemophagocytic lymphohistiocytosis (HLH) complicated with gastrointestinal bleeding. Methods: The clinical data of 52 patients with HLH diagnosed from January 2015 to February 2017 were analyzed retrospectively. Results: ①Of the 52 patients[including 36 cases of EBV related (69.2%) , 5 cases of lymphoma related (9.6%) , 3 cases of primary HLH (5.8%) , 3 cases of rheumatism related (5.8%) , 2 cases of tuberculosis related (3.8%) , 3 cases of unknown causes (3...
October 14, 2017: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
https://www.readbyqxmd.com/read/29166736/-prognosis-of-the-central-nervous-system-involvement-in-patients-with-hemophagocytic-lymphohistiocytosis
#4
F Y Wen, L Xiao, Y Xian, X H Wen, X M Guan, M L Liao, J Yu
Objective: To investigate the characteristics and prognostic factor of central nervous system (CNS) involvement in patients with hemophagocytic lymphohistiocytosis (HLH) . Methods: From January 2006 to October 2015, 152 patients with HLH, 88 patients had CNS involvement, their clinical data were collected, and survival was analyzed using the Kaplan-Meier life table method, univariate and multivariate Cox regression model analyses were applied to identify the risk factors of prognosis. Results: ①57.9% patients complicated with neurological symptoms, cerebrospinal fluid abnormalities were observed in 37...
October 14, 2017: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
https://www.readbyqxmd.com/read/29166722/-value-of-bedside-echocardiography-in-diagnosis-and-risk-assessment-of-in-hospital-death-for-patients-with-stanford-type-a-aortic-dissection
#5
H J Wang, Z Y Xiao, G R Gu, Y Xue, M Shao, Z Deng, Z G Tao, C L Yao, C Y Tong
Objective: To investigate the value of bedside echocardiography in diagnosis and risk assessment of in-hospital death of patients with Stanford type A aortic dissection. Methods: The clinical data of 229 patients with Stanford type A aortic dissection diagnosed by CT angiography in Zhongshan Hospital affiliated to Fudan University between January 2009 and January 2016 were retrospectively analyzed. The patients were divided into survival group(191 cases)and non-survival group(38 cases)according to presence or absence of in-hospital death...
November 24, 2017: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/29166717/-left-atrial-appendage-volume-is-a-valuable-predictor-of-atrial-fibrillation-recurrence-after-radiofrequency-catheter-ablation
#6
G A Zheng, C Y Lin, L Weng, J D Chen
Objective: To investigate the association between the left atrial appendage (LAA) volume and atrial fibrillation (AF) recurrence after radiofrequency catheter ablation. Methods: We prospectively enrolled sixty-two patients with AF (40 cases with paroxysmal AF, 22 cases with persistent AF) who successfully underwent a first AF catheter ablation and had performed contrast-enhanced cardiac computed tomography (CT) prior to the procedure to measure LAA volumes in our hospital from January 2012 to August 2015. Circumferential pulmonary vein isolation was performed under the guidance of three-dimension mapping system (CARTO system)...
November 24, 2017: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/29166673/factors-related-to-acupuncture-response-in-patients-with-chronic-severe-functional-constipation-secondary-analysis-of-a-randomized-controlled-trial
#7
Xingyue Yang, Yan Liu, Bing Liu, Liyun He, Zhishun Liu, Yanshi Yan, Jia Liu, Baoyan Liu
BACKGROUND: Acupuncture has been demonstrated to be effective and safe for chronic severe functional constipation (CSFC). However, which patients with CSFC will have a better response to acupuncture remains unclear. OBJECTIVE: To explore factors related to acupuncture response in patients with CSFC. METHODS: We performed a secondary analysis of a previous multicenter randomized controlled trial consisting of a 2-week run-in period, 8-week treatment, and 12-week follow-up without treatment in which patients with CSFC were randomly allocated to an electroacupuncture group or a sham electroacupuncture group...
2017: PloS One
https://www.readbyqxmd.com/read/29166672/increased-risk-of-dementia-following-herpes-zoster-ophthalmicus
#8
Ming-Chieh Tsai, Wan-Ling Cheng, Jau-Jiuan Sheu, Chung-Chien Huang, Ben-Chang Shia, Li-Ting Kao, Herng-Ching Lin
This retrospective cohort study aimed to examine the relationship between herpes zoster ophthalmicus (HZO) and the subsequent risk of dementia using a population-based database. We retrieved the study sample from the Taiwan Longitudinal Health Insurance Database 2005. The study group included 846 patients with HZO, and the comparison group included 2538 patients without HZO. Each patient was individually followed for a 5-year period to identify those patients who subsequently received a diagnosis of dementia...
2017: PloS One
https://www.readbyqxmd.com/read/29166492/waist-to-height-ratio-index-or-the-prediction-of-overweight-in-children
#9
Sarah Aparecida Vieira, Andréia Queiroz Ribeiro, Helen Hermana Miranda Hermsdorff, Patrícia Feliciano Pereira, Silvia Eloiza Priore, Sylvia do Carmo Castro Franceschini
OBJECTIVE: To identify a low-cost abdominal adiposity index that has a higher accuracy in predicting excess weight in children aged four to seven years old. METHODS: A cross-sectional study with a sample of 257 children aged 4 to 7 years old. Indicators of abdominal adiposity assessed were: waist circumference (WC), waist-to-height ratio (WHR) and central fat percentage (measured by dual energy X-ray absorptiometry - DEXA). Overweight children were classified using body mass index by age (BMI/age)...
November 17, 2017: Revista Paulista de Pediatria: Orgão Oficial da Sociedade de Pediatria de São Paulo
https://www.readbyqxmd.com/read/29166487/-mortality-from-assault-in-young-men-in-brazil-2010-2014-an-ecological-study
#10
Alice Cristina Medeiros Melo, Gabriela Drummond Marques da Silva, Leila Posenato Garcia
The aim was to analyze the association between risk of death from assault in young males and socio-demographic characteristics in Brazilian municipalities. In this ecological study, the units of analysis were the 1,651 municipalities of Brazil with more than 20,000 inhabitants. Data were obtained from the Brazilian Mortality Information System (SIM) and indicators were obtained from the 2010 Population Census and Human Development Atlas. Mortality rate ratios were estimated by a negative binomial regression model...
November 21, 2017: Cadernos de Saúde Pública
https://www.readbyqxmd.com/read/29166483/processed-and-ultra-processed-food-consumption-among-children-aged-13-to-35-months-and-associated-factors
#11
Mônica Araujo Batalha, Ana Karina Teixeira da Cunha França, Sueli Ismael Oliveira da Conceição, Alcione Miranda Dos Santos, Francelena de Sousa Silva, Luana Lopes Padilha, Antônio Augusto Moura da Silva
The aim of this study was to evaluate the consumption of processed and ultra-processed foods among children aged 13-35 months and its associated factors. We studied 1,185 children within the BRISA cohort in São Luís, Maranhão State, Brazil. The food consumption was investigated using a 24-hour recall, and the percentages of daily caloric intake and nutrients were estimated by food groups according to "NOVA" classification. We chose to categorize children belonging to the upper tertile of the distribution as having a high consumption of processed and ultra-processed food products...
November 21, 2017: Cadernos de Saúde Pública
https://www.readbyqxmd.com/read/29166459/could-infarct-location-predict-the-long-term-functional-outcome-in-childhood-arterial-ischemic-stroke
#12
Mauricio López-Espejo, Marta Hernández-Chávez
OBJECTIVE: To explore the influence of infarct location on long-term functional outcome following a first-ever arterial ischemic stroke (AIS) in non-neonate children. METHOD: The MRIs of 39 children with AIS (median age 5.38 years; 36% girls; mean follow-up time 5.87 years) were prospectively evaluated. Infarct location was classified as the absence or presence of subcortical involvement. Functional outcome was measured using the modified Rankin scale (mRS) for children after the follow-up assessment...
October 2017: Arquivos de Neuro-psiquiatria
https://www.readbyqxmd.com/read/29166451/factors-associated-with-frailty-in-a-community-dwelling-population-of-older-adults
#13
Danielle Teles da Cruz, Marcel de Toledo Vieira, Ronaldo Rocha Bastos, Isabel Cristina Gonçalves Leite
OBJECTIVE: To analyze if demographic and socioeconomic factors and factors related to health and health services are associated with frailty in community-dwelling older adults. METHODS: This is a cross-sectional study with 339 older adults (60 years old or more) living in Juiz de Fora, State of Minas Gerais, Brazil, in 2015. A household survey was carried out and frailty was evaluated using the Edmonton Frail Scale. For the analysis of the factors associated with outcome, a theoretical model of determination was constructed with three hierarchical blocks: block 1 with demographic and socioeconomic characteristics, block 2 with the health of the older adult (divided into three sub-levels: 2...
2017: Revista de Saúde Pública
https://www.readbyqxmd.com/read/29166447/prevalence-and-clinical-profile-of-chronic-pain-and-its-association-with-mental-disorders
#14
Flávia Garcia Pereira, Mariane Henriques França, Maria Cristina Alochio de Paiva, Laura Helena Andrade, Maria Carmen Viana
OBJECTIVE: To identify the prevalence of 12-month self-reported pain and chronic pain in a general population and to describe their clinical profile to assess if chronic pain is associated with 12-month mental disorders. METHODS: The data used comes from the São Paulo Megacity Mental Health Survey, a population-based study assessing adult (≥ 18 years) residents of the São Paulo metropolitan area, Brazil. We have assessed the respondents (n = 5,037) using the Composite International Diagnostic Interview (CIDI 3...
November 17, 2017: Revista de Saúde Pública
https://www.readbyqxmd.com/read/29166446/maternal-education-and-age-inequalities-in-neonatal-death
#15
Sandra Costa Fonseca, Patricia Viana Guimarães Flores, Kenneth Rochel Camargo, Rejane Sobrino Pinheiro, Claudia Medina Coeli
OBJECTIVE: Evaluate the interaction between maternal age and education level in neonatal mortality, as well as investigate the temporal evolution of neonatal mortality in each stratum formed by the combination of these two risk factors. METHODS: A nonconcurrent cohort study, resulting from a probabilistic relationship between the Mortality Information System and the Live Birth Information System. To investigate the risk of neonatal death we performed a logistic regression, with an odds ratio estimate for the combined variable of maternal education and age, as well as the evaluation of additive and multiplicative interaction...
November 17, 2017: Revista de Saúde Pública
https://www.readbyqxmd.com/read/29166445/regular-access-and-adherence-to-medications-of-the-specialized-component-of-pharmaceutical-services
#16
Janaína Soder Fritzen, Fabiane Raquel Motter, Vera Maria Vieira Paniz
OBJECTIVE: To investigate the prevalence of the adherence to the medications of the Specialized Component of Pharmaceutical Services and its association with regular access in users of these medications in the municipality of São Leopoldo, State of Rio Grande do Sul, Brazil. METHODS: This is a cross-sectional study with adults aged 20 years and over, who are users of medications of the Specialized Component of Pharmaceutical Services. Sampling was carried out consecutively for users who accessed the service of the Specialized Component of Pharmaceutical Services during the period from December 2014 to March 2015...
2017: Revista de Saúde Pública
https://www.readbyqxmd.com/read/29166438/prevalence-and-risk-factors-of-inadequate-medicine-home-storage-a-community-based-study
#17
Rand Randall Martins, Andreza Duarte Farias, Yonara Monique da Costa Oliveira, Rodrigo Dos Santos Diniz, Antonio Gouveia Oliveira
OBJECTIVE: Assess the extent of inadequate home storage of medicines andidentify important risk factors. METHODS: A cross-sectional survey based on a probability sample in the community, conducted in 267 households in Cuité, State of Paraíba, Northeast Brazil, in 2014. Logistic regression was used to study the risk factors. RESULTS: The prevalence of households with inadequate storage was 76.0%. Problems with storage include direct exposure to sunlight in 10...
November 17, 2017: Revista de Saúde Pública
https://www.readbyqxmd.com/read/29166435/smoking-among-adolescents-is-associated-with-their-own-characteristics-and-with-parental-smoking-cross-sectional-study
#18
Rafaela Campos Cuissi de Andrade, Aline Duarte Ferreira, Dionei Ramos, Ercy Mara Cipulo Ramos, Catarina Covolo Scarabottolo, Bruna Thamyres Ciccotti Saraiva, Luis Alberto Gobbo, Diego Giulliano Destro Christofaro
BACKGROUND: This study aimed to analyze the association between smoking during adolescence and the characteristics of smoking and alcohol consumption among their parents. DESIGN AND SETTING: Cross-sectional study in Londrina (PR), Brazil. METHODS: The subjects comprised 1,231 adolescents aged 14-17 years. The adolescents and their parents answered a self-report questionnaire that asked for sociodemographic information and data on smoking and alcohol consumption...
November 17, 2017: São Paulo Medical Journal, Revista Paulista de Medicina
https://www.readbyqxmd.com/read/29166432/engagement-in-physical-education-classes-and-health-among-young-people-does-sports-practice-matter-a-cross-sectional-study
#19
Diogo Henrique Constantino Coledam, Philippe Fanelli Ferraiol
CONTEXT AND OBJECTIVE: Physical education classes aim to promote health but it is unknown whether benefits occur independently of sports practice. The purpose of this study was to examine associations between engagement in physical education classes and physical fitness and obesity according to sports practice among Brazilian students. DESIGN AND SETTING: Cross-sectional school-based study involving 737 students aged 10-17 years in southern Brazil. METHODS: Engagement in physical education classes and sports practice were analyzed using a self-report questionnaire...
November 17, 2017: São Paulo Medical Journal, Revista Paulista de Medicina
https://www.readbyqxmd.com/read/29166412/mir-195-inhibits-macrophages-pro-inflammatory-profile-and-impacts-the-crosstalk-with-smooth-muscle-cells
#20
Joao Paulo Bras, Andreia Machado Silva, George A Calin, Mario Adolfo Barbosa, Susana Gomes Santos, Maria Ines Almeida
Macrophages are a main component of atherosclerotic plaques. Recent studies suggest that pro-inflammatory M1 macrophages are pro-atherogenic while M2 macrophages promote plaque stability. Moreover, toll-like receptor signalling pathways are implicated in atherosclerotic plaque formation, evolution and regression. We propose microRNAs as key regulators of these processes. In this context, our goal is to promote inflammation resolution using miR-195 to reduce M1-like macrophage polarization and to evaluate the molecular mechanisms underlying such effect, as well as to explore the functional consequences for smooth muscle cell recruitment...
2017: PloS One
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