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https://www.readbyqxmd.com/read/28732382/novel-strategies-to-prevent-the-development-of-multidrug-resistance-mdr-in-cancer
#1
REVIEW
Jinglu Wang, Nicole Seebacher, Huirong Shi, Quancheng Kan, Zhenfeng Duan
The development of multidrug resistance (MDR) is one of the major challenges to the success of traditional chemotherapy treatment in cancer patients. Most studies to date have focused on strategies to reverse MDR following its development. However, agents utilizing this approach have proven to be of limited clinical use, failing to demonstrate an improvement in therapeutic efficacy with almost no significant survival benefits observed in cancer clinical trials. An alternative approach that has been applied is to prevent or delay MDR prior or early in its development...
July 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/28732369/efficacy-and-safety-of-accelerated-partial-breast-irradiation-a-meta-analysis-of-published-randomized-studies
#2
Gengchun Liu, Zhongyi Dong, Baqun Huang, Yuelong Liu, Yan Tang, Qing Li, Yihui Zhu
BACKGROUND AND PURPOSE: Accelerated partial breast irradiation (APBI) technology has theoretical advantages in comparison with traditional adjuvant radiation therapy (whole-breast irradiation; WBI) after breast-conserving surgery. However, published randomized controlled trials have shown inconsistent outcomes. Therefore, a comprehensive assessment of the effectiveness and safety of APBI technology is needed. RESULTS: A total of 7 studies of 7452 patients were included in this analysis...
July 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/28732306/photostability-testing-using-online-reactor-hplc-hyphenation-and-mass-spectrometric-compound-identification-illustrated-by-ketoprofen-as-model-compound
#3
Jaber Assaf, Diego Zulkiewicz Gomes, Bernhard Wuest, Maria Kristina Parr
Investigations on the photochemical stability of pharmaceutical substances are mandatory in drug development and licensing as photo-induced degradation of an active pharmaceutical ingredient (API) may not only lead to decreased API concentrations but also to toxic or reactive products. Thus, the US Food and Drug Administration (FDA) and the International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH) issued Guidance for Industry Q1B "Photostability Testing of New Drug Substances and Products" for testing of pure but also packed drugs...
July 8, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28732275/plot-farm-and-watershed-scale-effects-of-coffee-cultivation-in-runoff-and-sediment-production-in-western-puerto-rico
#4
Carlos E Ramos-Scharrón, Yasiel Figueroa-Sánchez
The combination of a topographically abrupt wet-tropical setting with the high level of soil exposure that typifies many sun-grown coffee farms represents optimal conditions for high erosion rates. Although traditionally considered as a main cause for water resource degradation, limited empirical evidence has existed to document its true contribution. This study relies on plot-scale experimental results conducted in western Puerto Rico to assess the impact of cultivated surfaces and farm access roads on runoff and sediment production from the plot to the farm and watershed scales...
July 18, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28732126/chinese-isms-dimensions-in-mainland-china-and-taiwan-convergence-and-extension-of-american-isms-dimensions
#5
Zhuo Job Chen, Kung-Yu Hsu, Xinyue Zhou, Gerard Saucier
OBJECTIVE: Previous studies of American-English isms terms have uncovered as many as five broad factors: Tradition-oriented Religiousness (TR), Subjective Spirituality (SS), Communal Rationalism (CR), Unmitigated Self-Interest (USI), and Inequality Aversion (IA). The present studies took a similar lexical approach to investigate the Chinese-language isms structures in both mainland China and Taiwan. METHOD AND RESULTS: In Study 1, exploratory factor analyses with 915 mainland Chinese subjects uncovered four interpretable factors dimensionalizing 165 mainland Chinese dictionary isms terms...
July 21, 2017: Journal of Personality
https://www.readbyqxmd.com/read/28732107/characteristic-flavor-of-traditional-soup-made-by-stewing-chinese-yellow-feather-chickens
#6
Jun Qi, Deng-Yong Liu, Guang-Hong Zhou, Xing-Lian Xu
The traditional recipe for Chinese chicken soup creates a popular taste of particular umami and aroma. The present study investigated the effects of stewing time (1, 2, and 3 h) on the principal taste-active and volatile compounds and the overall flavor profile of traditional Chinese chicken soup by measuring the contents of free amino acids (FAAs), 5'-nucleotides, minerals and volatile compounds and by evaluating the taste and aroma profiles using an electronic nose, an electronic tongue and a human panel...
July 21, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/28732054/types-of-devices-used-in-ridge-split-procedure-for-alveolar-bone-expansion-a-systematic-review
#7
Nayansi Jha, Eun Ha Choi, Nagendra Kumar Kaushik, Jae Jun Ryu
The aim of this systematic review was to evaluate instrumentation procedures of the alveolar ridge expansion technique (ARST) with or without Guided Bone Regeneration (GBR) and to identify the most used instruments for successful outcome. An electronic as well as manual literature search was conducted in several databases including Medline, Embase, and Cochrane Central Register of Controlled Trials, for articles written in English up to September 2016. The question in focus was to identify the type of device for ridge expansion that is most frequently used and provides adequate bone expansion and implant success rate...
2017: PloS One
https://www.readbyqxmd.com/read/28732033/spatial-and-simultaneous-representative-seroprevalence-of-anti-toxoplasma-gondii-antibodies-in-owners-and-their-domiciled-dogs-in-a-major-city-of-southern-brazil
#8
Aline do Nascimento Benitez, Felippe Danyel Cardoso Martins, Marcelle Mareze, Nelson Jessé Rodrigues Santos, Fernanda Pinto Ferreira, Camila Marinelli Martins, João Luis Garcia, Regina Mitsuka-Breganó, Roberta Lemos Freire, Alexander Welker Biondo, Italmar Teodorico Navarro
Toxoplasmosis, caused by Toxoplasma gondii, has traditionally been considered an important water and foodborne protozoonosis with important public health considerations. Although felids play a well-established role as definitive hosts, canine epidemiological involvement in the parasite's life cycle remains questionable and controversial. The increasing closeness of the human-dog bond, particularly seen in urban settings, has been recognized as a historically unprecedented worldwide movement. Sharing daily lives in the same households, dogs may be exposed to similar associated risks of T...
2017: PloS One
https://www.readbyqxmd.com/read/28732020/setting-strategy-of-delay-optimization-oriented-smac-contention-window-size
#9
Yuan Rao, Cheng Deng, Jun Su, Yan Qiao, Jun Zhu, Ru-Chuan Wang
Some frame components, such as SYNC (frame synchronization) and RTS/CTS (Ready to Send/Clear to Send), are not taken into consideration when the traditional setting strategies conduct the optimization of SMAC (Sensor MAC) contention window size. This paper proposes mathematical models that allow the analysis of data packets forwarding delay within one SMAC virtual cluster. Simulation results in OMNeT++ show good agreements with the proposed mathematical models, validating the models' correctness. The curve analyses of the models confirm the existence of delay-optimization-oriented contention window size that is closely related to the number of simultaneously contending nodes...
2017: PloS One
https://www.readbyqxmd.com/read/28731932/investing-in-physicians-is-investing-in-patients-enhancing-patient-safety-through-physician-health-and-well-being-research
#10
Elizabeth Brooks, Doris C Gundersen, Michael H Gendel
Keeping medical practitioners healthy is an important consideration for workforce satisfaction and retention, as well as public safety. However, there is limited evidence demonstrating how to best care for this group. The absence of data is related to the lack of available funding in this area of research. Supporting investigations that examine physician health often "fall through the cracks" of traditional funding opportunities, landing somewhere between patient safety and workforce development priorities...
July 20, 2017: Journal of Patient Safety
https://www.readbyqxmd.com/read/28731641/macronutrient-content-and-food-exchanges-for-48-greek-mediterranean-dishes
#11
Paraskevi Detopoulou, Maria Aggeli, Elena Andrioti, Maria Detopoulou
AIM: The purpose of the present study was to facilitate the translation of traditional Greek Mediterranean recipes into food exchanges for diabetes. Moreover, it provides a useful food list for meal planning, which can be used by health professionals and nutritionists, as well as researchers and the public. METHODS: A total of 48 traditional Greek Mediterranean dishes were selected in order to include appetisers, sauces, salads, pies, dishes with vegetables and legumes as well as egg, pasta, rice, meat, fish and poultry-based dishes...
April 2017: Nutrition & Dietetics: the Journal of the Dietitians Association of Australia
https://www.readbyqxmd.com/read/28731553/trends-in-fluid-consumption-and-beverage-choices-among-adults-reveal-preferences-for-ayran-and-black-tea-in-central-turkey
#12
Reyhan Nergiz-Unal, Emine Akal Yildiz, Gülhan Samur, H Tanju Besler, Neslisşah Rakicioğlu
AIM: Beverages are globally significant sources of water in the diet. There is a lack of knowledge about fluid intake from beverage and water consumption in Turkey. Thus, the aim of this study was to examine the type of drinks preferred at meals and snacks as well as the daily fluid, beverage and water intakes based on age and gender. METHODS: A cross-sectional survey was administered to 3411 randomly chosen adult participants (n = 1522 male, n = 1919 female) representing the general profile of central Turkey...
February 2017: Nutrition & Dietetics: the Journal of the Dietitians Association of Australia
https://www.readbyqxmd.com/read/28731544/localized-mrs-reliability-of-in-vivo-glutamate-at-3%C3%A2-t-in-shortened-scan-times-a-feasibility-study
#13
J Eric Jensen, Randy P Auerbach, Angela Pisoni, Diego A Pizzagalli
Glutamate is the prime excitatory neurotransmitter in the mammalian brain and has been implicated in a wide range of psychiatric conditions. To improve the applicability and clinical reach of magnetic resonance spectroscopy (MRS), research is needed to develop shortened, yet reliable, MRS scanning procedures for standard 1.5-3-T clinical magnetic resonance imaging (MRI) systems, particularly with young or vulnerable populations unable to tolerate longer protocols. To this end, we evaluated the test-retest reliability of a shortened J-resolved MRS sequence in healthy adolescents (n = 22) aged 12-14 years...
July 21, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/28731501/eyeball-position-in-facial-approximation-accuracy-of-methods-for-predicting-globe-positioning-in-lateral-view
#14
Pavla Zednikova Mala, Jana Veleminska
This study measured the accuracy of traditional and validated newly proposed methods for globe positioning in lateral view. Eighty lateral head cephalograms of adult subjects from Central Europe were taken, and the actual and predicted dimensions were compared. The anteroposterior eyeball position was estimated as the most accurate method based on the proportion of the orbital height (SEE = 1.9 mm) and was followed by the "tangent to the iris method" showing SEE = 2.4 mm. The traditional "tangent to the cornea method" underestimated the eyeball projection by SEE = 5...
July 21, 2017: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/28731396/contralateral-posterior-interhemispheric-approach-to-deep-medial-parietooccipital-vascular-malformations-surgical-technique-and-results
#15
Jan-Karl Burkhardt, Ethan A Winkler, Michael T Lawton
OBJECTIVE Deep medial parietooccipital arteriovenous malformations (AVMs) and cerebral cavernous malformations (CCMs) are traditionally resected through an ipsilateral posterior interhemispheric approach (IPIA), which creates a deep, perpendicular perspective with limited access to the lateral margins of the lesion. The contralateral posterior interhemispheric approach (CPIA) flips the positioning, with the midline positioned horizontally for retraction due to gravity, but with the AVM on the upper side and the approach from the contralateral, lower side...
July 21, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28731368/computerized-planning-of-prostate-cryosurgery-and-shape-considerations
#16
Purva Joshi, Anjali Sehrawat, Yoed Rabin
The current study aims to explore possible relationships between various prostate shapes and the difficulty in creating a computer-based plan for cryosurgery. This research effort is a part of an ongoing study to develop computational means in order to improve cryosurgery training and education. This study uses a computerized planner-a key building block of a recently developed prototype for cryosurgery training. The quality of planning is measured by the overall defect volume, a proprietary concept which refers to undercooled areas internal to the target region and overcooled areas external to it...
January 1, 2017: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/28731366/chondromyxoid-fibroma-of-the-distal-fibula-treated-by-percutaneous-radiofrequency-ablation
#17
Tamar Berenstein-Weyel, Ehud Lebel, Daniela Katz, Yaakov Applbaum, Amos Peyser
BACKGROUND: Percutaneous radiofrequency ablation (RFA) has been shown to be an effective treatment for soft tissue lesions and also benign bone tumors, especially osteoid osteoma. There are limited data regarding this technique in other bone tumors, specifically larger and more aggressive ones. PURPOSES: To describe the use of RFA as a definitive treatment and an alternative to traditional open surgery for the treatment of chondromyxoid fibroma (CMF), a benign but locally aggressive bone tumor...
May 2017: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/28731343/-roller-wheel-pt-containing-small-molecules-and-the-impact-of-rollers-on-material-crystallinity-electronic-properties-and-solar-cell-performance
#18
Wenhan He, Maksim Y Livshits, Diane A Dickie, Zhen Zhang, Luis E Mejiaortega, Jeffrey J Rack, Qin Wu, Yang Qin
We report the synthesis, characterization and detailed comparison of a series of novel Pt-bisacetylide containing conjugated small molecules possessing an unconventional "roller-wheel" shaped structure that is distinctly different from the "dumbbell" designs in traditional Pt-bisacetylide containing conjugated polymers and small molecules. The relationship between the chemical nature and length of the "rollers" and the electronic and physical properties of the materials are carefully studied by steady state spectroscopy, cyclic voltammetry, differential scanning calorimetry, single-crystal X-ray diffraction, transient absorption spectroscopy, theoretical calculation and device application...
July 21, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28731322/large-scale-stretchable-semi-embedded-copper-nanowires-transparent-conductive-films-by-electrospinning-template
#19
Xia Yang, Xiaotian Hu, Qingxia Wang, Jian Xiong, Hanjun Yang, Xiangchuan Meng, Licheng Tan, Lie Chen, Yiwang Chen
With recent emergence of wearable electronic devices, the flexible and stretchable transparent electrodes are the core components to realize innovative devices. Copper nanowires (CuNWs) network is commonly chosen because of its high conductivity and transparency. However, the junction resistances and low aspect ratios still limit its further stretchable performance. Herein, a large-scale stretchable semi-embedded CuNWs transparent conductive film (TCFs) was fabricated by electrolessly depositing Cu on the electrospun poly (4-vinylpyridine) (P4VP) polymer template semi-embedded in polydimethylsiloxane (PDMS)...
July 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28731232/a-comprehensive-review-of-agrimoniin
#20
REVIEW
Daniel M Grochowski, Krystyna Skalicka-Woźniak, Ilkay Erdogan Orhan, Jianbo Xiao, Marcello Locatelli, Jakub P Piwowarski, Sebastian Granica, Michał Tomczyk
Plant tannins are a unique class of polyphenols with relatively high molecular weights. Within the ellagitannins group, agrimoniin--dimeric ellagitannin--is one of the most representative compounds found in many plant materials belonging to the Rosaceae family. Agrimoniin was first isolated in 1982 from roots of Agrimonia pilosa Ledeb. (Rosaceae), a plant traditionally used in Japan and China as an antidiarrheal, hemostatic, and antiparasitic agent. Agrimoniin is a constituent of medicinal plants, which are often applied orally in the form of infusions, decoctions, or tinctures...
July 21, 2017: Annals of the New York Academy of Sciences
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