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https://www.readbyqxmd.com/read/29913540/-significance-of-matrix-augmented-bone-marrow-stimulation-for-treatment-of-cartilage-defects-of-the-knee-a-consensus-statement-of-the-dgou-working-group-on-tissue-regeneration
#1
Philipp Niemeyer, Christoph Becher, Matthias Buhs, Stefan Fickert, Kolja Gelse, Daniel Günther, Raphael Kaelin, Peter Kreuz, Jörg Lützner, Stefan Nehrer, Henning Madry, Stefan Marlovits, Julian Mehl, Henning Ott, Matthias Pietschmann, Gunther Spahn, Thomas Tischer, Martin Volz, Markus Walther, Götz Welsch, Johannes Zellner, Wolfgang Zinser, Peter Angele
Surgical principles for treatment of full-thickness cartilage defects of the knee include bone marrow stimulation techniques (i.e. arthroscopic microfracturing) and transplantation techniques (i.e. autologous chondrocyte implantation and osteochondral transplantation). On the basis of increasing scientific evidence, indications for these established therapeutical concepts have been specified and clear recommendations for practical use have been given. Within recent years, matrix-augmented bone marrow stimulation has been established as a new treatment concept for chondral lesions...
June 18, 2018: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/29913440/validation-of-a-new-low-cost-methanol-based-fixative-for-cervical-cytology-and-human-papillomavirus-detection
#2
Katia Ramos Moreira Leite, Thais Silva, Bruna Naum, Flavio Canavez, Juliana Canavez, Ruan Pimenta, Sabrina Reis, Luiz Heraldo Camara-Lopes
OBJECTIVE: To test the performance of a new fixative for pap smear collection for liquid-based cervical cytology, CellPreserv® and compare it with the commercially available, PreservCyt® used in the diagnosis and detection of human papillomavirus (HPV). METHODS: Seven hundred twenty five women participated in this study after signing an informed consent. The specimens were collected using a traditional device, agitated in PBS, and equally divided in both fixatives...
June 18, 2018: Acta Cytologica
https://www.readbyqxmd.com/read/29913415/reduction-in-co-2-emissions-in-roro-pax-ports-equipped-with-automatic-mooring-systems
#3
REVIEW
Emma Díaz-Ruiz-Navamuel, Andrés Ortega Piris, Carlos A Pérez-Labajos
Faced with the unavoidable reality of the emission of pollutant gases by vessels both while sailing and when performing in-port manoeuvres, the international community has devised an extensive set of rules to limit greenhouse gas emissions and the emission of other pollutants which are bad for our health. In order to make these reductions in the emissions, the areas addressed are the engine regime or speed control, the quality of the fuel used, the state of conservation of the vessel and its hull or the time taken to perform the manoeuvres of mooring and unmooring...
June 14, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29913348/from-linear-care-plan-through-concept-map-to-concepto-plan-the-creation-of-an-innovative-and-holistic-care-plan
#4
M Sherry McDonald, Melanie Neumeier, Mark E Olver
Linear care plans have traditionally been used in nursing education to support nursing students in identifying potential and actual health care problems, and to follow up on those issues with nursing interventions. However, the linear care plan does not support the nursing student with learning in-depth critical thinking, clinical reasoning, creative thinking, and other ways of thinking. Concept mapping was introduced as a way to support the nursing student to improve upon critical thinking and clinical reasoning and to identify relationships among the patient's health care problems...
May 26, 2018: Nurse Education in Practice
https://www.readbyqxmd.com/read/29913312/exploring-the-udoteaceae-diversity-bryopsidales-chlorophyta-in-the-caribbean-region-based-on-molecular-and-morphological-data
#5
Laura Lagourgue, Nicolas Puillandre, Claude Payri
The Udoteaceae family (Bryopsidales, Chlorophyta) is known to be highly diverse morphologically in the Caribbean region, but only few studies have studied its genetic diversity. Using an integrative taxonomic approach, this study aimed at (1) exploring the Udoteaceae species diversity using a combination of five DNA-based species delimitation methods and morpho-anatomical data for confirmation; (2) estimating the discriminatory power of traditional diagnostic characters using a morphology-based clustering method and statistical analyses focused on the genus Udotea; and (3) reconstructing the phylogeny of the family based on a multilocus analysis (tufA, rbcL, 18S rDNA)...
June 15, 2018: Molecular Phylogenetics and Evolution
https://www.readbyqxmd.com/read/29913311/phylogenetic-relationships-and-classification-of-the-holarctic-family-leuciscidae-cypriniformes-cyprinoidei
#6
Susana Schönhuth, Jasna Vukic, Radek Sanda, Lei Yang, Richard L Mayden
The phylogenetic relationships and classification of the freshwater fish order Cypriniformes, like many other species-rich groups of vertebrates, has evolved over time with some consistency and inconsistencies of relationships across various studies. Within Cypriniformes, the Holarctic family Leuciscidae is one of the most widely distributed and highly diverse monophyletic groups of cyprinoids. Despite several studies conducted on this group, alternative hypotheses exist as to the composition and relationships within Leuciscidae...
June 15, 2018: Molecular Phylogenetics and Evolution
https://www.readbyqxmd.com/read/29913301/in-vivo-and-in-vitro-anti-inflammatory-effects-of-sophora-flavescens-residues
#7
Hongyan Ma, Qi Huang, Wenshan Qu, Linyuan Li, Min Wang, Shao Li, Fujiang Chu
ETHNOPHARMACOLOGICAL RELEVANCE: The dried roots of Sophora flavescens Ait. (Leguminosae) is traditionally used as antipyretic medicine to reduce inflammation. It is well known that alkaloids and flavonoids are the main constituents of S. flavescens. However, the clinical researches and applications of S. flavescens is mainly based on its water-extracted alkaloids, its flavonoids may still remain in residues and have been underused. With development and manufacturing of S. flavescens in recent years, more herb residues are being produced...
June 15, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29913300/the-genus-pterocaulon-asteraceae-a-review-on-traditional-medicinal-uses-chemical-constituents-and-biological-properties
#8
REVIEW
Bruna Medeiros-Neves, Helder Ferreira Teixeira, Gilsane Lino von Poser
ETHNOPHARMACOLOGICAL RELEVANCE: Species of the genus Pterocaulon (Asteraceae) are used in different parts of the world for mainly to treat skin and liver diseases, as well as disorders of the respiratory system, among others. AIM OF THE STUDY: This review aims to discuss the present state of the art concerning the ethnobotanical uses, secondary metabolites and biological effects of Pterocaulon species and their chemical components. MATERIALS AND METHODS: The available information on the genus Pterocaulon was gathered from scientific databases (Web of Science, Pubmed, ScienceDirect, Scopus, ChemSpider, SciFinder ACS Publications, Wiley Online Library)...
June 15, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29913298/antihypertensive-effect-of-the-methanolic-extract-from-eruca-sativa-mill-brassicaceae-in-rats-muscarinic-receptor-linked-vasorelaxant-and-cardiotonic-effects
#9
Umme Salma, Taous Khan, Abdul Jabbar Shah
ETHNOPHARMACOLOGICAL RELEVANCE: Eruca sativa Mill., (Brassicaceae) is a popular remedy for the treatment of hypertension in Pakistan. However, direct effect of the extract and its fractions on blood pressure and vascular tone are unknown. AIM OF THE STUDY: This investigation was aimed to explore the pharmacological base for the traditional use of E. sativa in hypertension. MATERIALS AND METHODS: In-vivo blood pressure study was carried out using normotensive and high salt-induced hypertensive rats under anaesthesia...
June 15, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29913161/the-solution-structure-of-ccl28-reveals-structural-lability-that-does-not-constrain-antifungal-activity
#10
Monica A Thomas, Jie He, Francis C Peterson, Anna R Huppler, Brian F Volkman
The chemokine CCL28 is constitutively expressed in mucosal tissues and is abundant in low-salt mucosal secretions. Beyond its traditional role as a chemoattractant, CCL28 has been shown to act as a potent and broad-spectrum antimicrobial agent with particular efficacy against the commensal fungus and opportunistic pathogen Candida albicans. However, the structural features that allow CCL28 to perform its chemotactic and antimicrobial functions remain unknown. Here, we report the structure of CCL28, solved using nuclear magnetic resonance spectroscopy...
June 15, 2018: Journal of Molecular Biology
https://www.readbyqxmd.com/read/29913139/giardia-lamblia-identification-of-peroxisomal-like-proteins
#11
Karla Acosta-Virgen, Bibiana Chávez-Munguía, Daniel Talamás Lara, Anel Lagunes-Guillén, Aaron Martínez-Higuera, Antonio Lazcano, Adolfo Martínez-Palomo, Martha Espinosa-Cantellano
The protozoan parasite Giardia lamblia has traditionally been reported as lacking peroxisomes, organelles involved in fatty acid metabolism and detoxification of reactive oxygen species. We here report the finding with transmission electron microscopy of an oxidase activity in cytoplasmic vesicles of trophozoites and cysts of G. lamblia. These vesicles were positive to 3,3'-diaminobenzidine and to cerium chloride staining. In addition, using bioinformatic tools, two peroxisomal proteins were identified in the G...
June 15, 2018: Experimental Parasitology
https://www.readbyqxmd.com/read/29913085/a-software-program-to-assist-coding-of-prelinguistic-vocalizations-in-real-time
#12
Elisabeth Willadsen, Christina Persson, Duncan Appelbe
Numerous studies have confirmed that prelinguistic utterances are precursors to speech, and there is ample evidence that, for example, frequency of canonical syllables and syllable inventory size correlate with speech and language measures at older ages. Traditionally, prelinguistic utterances have been assessed by phonetic transcription which is difficult and time-consuming in infants. Recently, a more time-efficient methodology to assess prelinguistic utterances in real time, called naturalistic listening, was developed (Ramsdell et al...
June 18, 2018: Clinical Linguistics & Phonetics
https://www.readbyqxmd.com/read/29913084/demographic-comparison-of-american-individuals-in-polyamorous-and-monogamous-relationships
#13
Rhonda N Balzarini, Christoffer Dharma, Taylor Kohut, Bjarne M Holmes, Lorne Campbell, Justin J Lehmiller, Jennifer J Harman
Research on polyamorous relationships has increased substantially over the past decade. This work has documented how polyamory is practiced and why individuals might pursue such arrangements. However, there is a lack of a systematic investigation of who is in polyamorous relationships and how they might differ from individuals in monogamous relationships. The present study is one of the first to address this by comparing the demographic backgrounds of individuals in polyamorous (N = 2,428) and monogamous (N = 539) relationships in the United States...
June 18, 2018: Journal of Sex Research
https://www.readbyqxmd.com/read/29912990/peptide-conjugated-phosphodiamidate-oligomer-mediated-exon-skipping-has-benefits-for-cardiac-function-in-mdx-and-cmah-mdx-mouse-models-of-duchenne-muscular-dystrophy
#14
Alison M Blain, Elizabeth Greally, Graham McClorey, Raquel Manzano, Corinne A Betts, Caroline Godfrey, Liz O'Donovan, Thibault Coursindel, Mike J Gait, Matthew J Wood, Guy A MacGowan, Volker W Straub
Cardiac failure is a major cause of mortality in patients with Duchenne muscular dystrophy (DMD). Antisense-mediated exon skipping has the ability to correct out-of-frame mutations in DMD to produce truncated but functional dystrophin. Traditional antisense approaches have however been limited by their poor uptake into cardiac muscle. The addition of cell-penetrating peptides to antisense molecules has increased their potency and improved their uptake into all muscles, including the heart. We have investigated the efficacy of the Peptide-conjugated phosphodiamidate morpholino oligomer (P-PMO) Pip6a-PMO, for restoration of cardiac dystrophin and functional rescue in DMD mice- the mdx mouse and the less well characterised Cmah-/-mdx mouse (which carry a human-like mutation in the mouse Cmah gene as well as a mutation in DMD)...
2018: PloS One
https://www.readbyqxmd.com/read/29912978/mediterranean-diet-and-quality-of-life-baseline-cross-sectional-analysis-of-the-predimed-plus-trial
#15
Iñigo Galilea-Zabalza, Pilar Buil-Cosiales, Jordi Salas-Salvadó, Estefanía Toledo, Carolina Ortega-Azorín, Javier Díez-Espino, Zenaida Vázquez-Ruiz, María Dolores Zomeño, Jesús Vioque, José Alfredo Martínez, Dora Romaguera, Napoleón Perez-Farinos, José López-Miranda, Ramón Estruch, Aurora Bueno-Cavanillas, Fernando Arós, Josep Antoni Tur, Francisco Tinahones, Lluis Serra-Majem, Alba Marcos-Delgado, Manuel Ortega-Calvo, Clotilde Vázquez, Xavier Pintó, Josep Vidal, Lidia Daimiel, Miguel Delgado-Rodríguez, Pilar Matía, Dolores Corella, Andrés Diaz-López, Nancy Babio, Miguel Angel Muñoz, Montse Fitó, Sandra González-Palacios, Itziar Abete, Antonio García-Rios, Emilio Ros, Miguel Ángel Martínez-González
We assessed if a 17-item score capturing adherence to a traditional Mediterranean diet (MedDiet) was associated with better health-related quality of life among older Spanish men and women with overweight or obesity harboring the metabolic syndrome. We analyzed baseline data from 6430 men and women (age 55-70 years) participating in the PREDIMED-Plus study. PREDIMED-Plus is a multi-centre randomized trial testing an energy-restricted MedDiet combined with promotion of physical activity and behavioral therapy for primary cardiovascular prevention compared to a MedDiet alone...
2018: PloS One
https://www.readbyqxmd.com/read/29912933/assessing-the-multi-scale-predictive-ability-of-ecosystem-functional-attributes-for-species-distribution-modelling
#16
Salvador Arenas-Castro, João Gonçalves, Paulo Alves, Domingo Alcaraz-Segura, João P Honrado
Global environmental changes are rapidly affecting species' distributions and habitat suitability worldwide, requiring a continuous update of biodiversity status to support effective decisions on conservation policy and management. In this regard, satellite-derived Ecosystem Functional Attributes (EFAs) offer a more integrative and quicker evaluation of ecosystem responses to environmental drivers and changes than climate and structural or compositional landscape attributes. Thus, EFAs may hold advantages as predictors in Species Distribution Models (SDMs) and for implementing multi-scale species monitoring programs...
2018: PloS One
https://www.readbyqxmd.com/read/29912932/openness-to-experience-and-stress-responsivity-an-examination-of-cardiovascular-and-underlying-hemodynamic-trajectories-within-an-acute-stress-exposure
#17
Páraic S O'Súilleabháin, Siobhán Howard, Brian M Hughes
The personality trait openness to experience has been implicated in health, and in particular cardiovascular wellbeing. In a sample of 62 healthy young female adults, the role of openness in cardiovascular responsivity during a stress exposure was examined. Traditionally, methodologies have averaged a stress exposure into a single reading. This may be limited in that it does not consider patterns of cardiovascular adaptation within a stress exposure. Continuous cardiovascular data were reduced to mean 10 second readings, with phases determined through examinations of shifts in responsivity between each 10 second pairing...
2018: PloS One
https://www.readbyqxmd.com/read/29912907/evaluation-of-the-genexpert-mtb-rif-in-patients-with-presumptive-tuberculous-meningitis
#18
Tatiana Metcalf, Jaime Soria, Silvia M Montano, Eduardo Ticona, Carlton A Evans, Luz Huaroto, Matthew Kasper, Eric S Ramos, Nicanor Mori, Podjanee Jittamala, Kesinee Chotivanich, Irwin F Chavez, Pratap Singhasivanon, Sasithon Pukrittayakamee, Joseph R Zunt
BACKGROUND: Meningitis caused by Mycobacterium tuberculosis is a major cause of morbidity and mortality worldwide. We evaluated the performance of cerebrospinal fluid (CSF) testing with the GeneXpert MTB/RIF assay versus traditional approaches for diagnosing tuberculosis meningitis (TBM). METHODS: Patients were adults (n = 37) presenting with suspected TBM to the Hospital Nacional Dos de Mayo, Lima, Peru, during 12 months until 1st January 2015. Each participant had a single CSF specimen that was divided into aliquots that were concurrently tested for M...
2018: PloS One
https://www.readbyqxmd.com/read/29912879/polyclonal-human-antibodies-against-glycans-bearing-red-meat-derived-non-human-sialic-acid-n-glycolylneuraminic-acid-are-stable-reproducible-complex-and-vary-between-individuals-total-antibody-levels-are-associated-with-colorectal-cancer-risk
#19
Annie N Samraj, Kimberly A Bertrand, Robert Luben, Zahra Khedri, Hai Yu, Dzung Nguyen, Christopher J Gregg, Sandra L Diaz, Sherilyn Sawyer, Xi Chen, Heather Eliassen, Vered Padler-Karavani, Kana Wu, Kay-Tee Khaw, Walter Willett, Ajit Varki
BACKGROUND: N-glycolylneuraminic acid (Neu5Gc) is a non-human red-meat-derived sialic acid immunogenic to humans. Neu5Gc can be metabolically incorporated into glycan chains on human endothelial and epithelial surfaces. This represents the first example of a "xeno-autoantigen", against which circulating human "xeno-autoantibodies" can react. The resulting inflammation ("xenosialitis") has been demonstrated in human-like Neu5Gc-deficient mice and contributed to carcinoma progression via antibody-mediated inflammation...
2018: PloS One
https://www.readbyqxmd.com/read/29912863/reversing-allosteric-communication-from-detecting-allosteric-sites-to-inducing-and-tuning-targeted-allosteric-response
#20
Wei-Ven Tee, Enrico Guarnera, Igor N Berezovsky
The omnipresence of allosteric regulation together with the fundamental role of structural dynamics in this phenomenon have initiated a great interest to the detection of regulatory exosites and design of corresponding effectors. However, despite a general consensus on the key role of dynamics most of the earlier efforts on the prediction of allosteric sites are heavily crippled by the static nature of the underlying methods, which are either structure-based approaches seeking for deep surface pockets typical for "traditional" orthosteric drugs or sequence-based techniques exploiting the conservation of protein sequences...
June 18, 2018: PLoS Computational Biology
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