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https://www.readbyqxmd.com/read/29096879/non-invasive-fetal-rhd-genotyping-for-rhd-negative-women-stratified-into-rhd-gene-deletion-or-variant-groups-comparative-accuracy-using-two-blood-collection-tube-types
#1
Catherine A Hyland, Glenda M Millard, Helen O'Brien, Elizna M Schoeman, Genghis H Lopez, Eunike C McGowan, Anne Tremellen, Rachel Puddephatt, Kirsten Gaerty, Robert L Flower, Jonathan A Hyett, Glenn J Gardener
Non-invasive fetal RHD genotyping in Australia to reduce anti-D usage will need to accommodate both prolonged sample transport times and a diverse population demographic harbouring a range of RHD blood group gene variants. We compared RHD genotyping accuracy using two blood sample collection tube types for RhD negative women stratified into deleted RHD gene haplotype and RHD gene variant cohorts. Maternal blood samples were collected into EDTA and cell-free (cf)DNA stabilising (BCT) tubes from two sites, one interstate...
October 30, 2017: Pathology
https://www.readbyqxmd.com/read/29096422/non-invasive-fetal-rhd-genotyping-of-rhd-negative-pregnant-women-for-targeted-anti-d-therapy-in-australia-a-cost-effectiveness-analysis
#2
Louisa G Gordon, Catherine Hyland, Jon Hyett, Helen O'Brien, Glenda Millard, Robert Flower, Glenn Gardener
To undertake a cost-effectiveness analysis of non-invasive fetal RHD genotyping to target pregnant women for antenatal anti-D prophylaxis therapy. METHOD: A decision-analytic model was constructed to compare RHD testing and targeted anti-D prophylaxis, with current universal anti-D prophylaxis among pregnant women with RhD negative blood type. Model estimates were derived from national perinatal statistics, published literature, donor program records and national cost sources. One-way sensitivity analyses addressed the uncertainty of variables on the main findings...
November 2, 2017: Prenatal Diagnosis
https://www.readbyqxmd.com/read/29076164/nonhemolytic-passenger-lymphocyte-syndrome
#3
S Gerald Sandler, Suhua Han, Albert Langeberg, Cal Matsumoto, Thomas M Fishbein
BACKGROUND: An 8-month-old recipient of a liver segment transplant had anti-D detected for the first time in her Day 5 posttransplant plasma and anti-C detected for the first time in her Day 55 posttransplant plasma. The donor's plasma contained anti-C and anti-D. Clinical and laboratory findings established a diagnosis of passenger lymphocyte syndrome (PLS). Hemolysis did not occur, because the recipient's blood group phenotype was, by chance, D- C-. STUDY DESIGN AND METHODS: To evaluate contemporary practice for diagnosing PLS, we conducted a retrospective 10-year literature review...
October 26, 2017: Transfusion
https://www.readbyqxmd.com/read/29071816/application-of-multiplex-ligation-dependent-probe-amplification-assay-for-genotyping-major-blood-group-systems-including-del-variants-in-the-d-negative-korean-population
#4
Banseok Kim, Seung Tae Lee, Sinyoung Kim, Jong Rak Choi, Hyun Ok Kim
BACKGROUND: The DEL blood type, a very weak D variant, is a major concern in the field of transfusion medicine because of its potential to cause anti-D alloimmunization. We investigated the molecular basis of serologically D-negative phenotypes, including the DEL type, and the distribution of other blood group systems in the Korean population using the recently developed multiplex ligation-dependent probe amplification (MLPA) assay. METHODS: Blood group genotyping using the MLPA assay and RhCE phenotyping were performed on randomly selected 95 D-negative red blood cell products...
January 2018: Annals of Laboratory Medicine
https://www.readbyqxmd.com/read/29053863/a-case-of-a-newborn-with-blocked-rhd-antigen-and-hdfn
#5
Haijuan Wang, Jian Chen, Yongmei Jiang
A group O RhD-negative pregnant patient with anti-D antibody at titer 1:2048 delivered a baby boy by cesarean section at 38 + 6 weeks gestational age. The neonate typed as group O, but D antigen was at first uncertain. DAT and antibody screen of newborn were both positive. Various assays were used for D antigen determination. Ultimately, D antigen blocked by high-titer maternal anti-D antibody was confirmed. Total bilirubin of the newborn was 52.7 umol/L, and hemoglobin was 1.46 mg/dL. O RhD-negative red cells were used for an exchange transfusion...
November 8, 2017: Laboratory Medicine
https://www.readbyqxmd.com/read/29046203/-clinical-effect-of-anti-d-immunoglobulin-in-treatment-of-childhood-immune-thrombocytopenia-a-meta-analysis
#6
Wei Qin, Shao-Ling Huang, Ting-Ting Li
OBJECTIVE: To investigate the clinical effect and safety of anti-D immunoglobulin (anti-D) in the treatment of children with newly diagnosed acute immune thrombocytopenia (ITP) through a Meta analysis. METHODS: PubMed, EMBASE, Cohrane Library, Ovid, CNKI, and Wanfang Data were searched for randomized controlled trials (RCTs) published up to April 2017. Review Manager 5.3 was used for the Meta analysis. RESULTS: Seven RCTs were included. The Meta analysis showed that after 72 hours and 7 days of treatment, the intravenous immunoglobulin (IVIG) group had a significantly higher percentage of children who achieved platelet count >20×10(9)/L than the anti-D group (P<0...
October 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/29043831/del-phenotype
#7
Dong H Kwon, S G Sandler, Willy A Flegel
DEL red blood cells (RBCs) type as D- by routine serologic methods and are transfused routinely, without being identified as expressing a very weak D antigen, to D- recipients. DEL RBCs are detected only by adsorption and elution of anti-D or by molecular methods. Most DEL phenotypes have been reported in population studies conducted in East Asia, although DEL phenotypes have been detected also among Caucasian individuals. Approximately 98 percent of DEL phenotypes in East Asians are associated with the RHD*DEL1 or RHD*01EL...
September 2017: Immunohematology
https://www.readbyqxmd.com/read/28970689/the-prozone-effect-exerted-by-the-complement-binding-anti-le-a-on-anti-d
#8
Sanmukh R Joshi, Kamlesh H Parekh
BACKGROUND: Prozone phenomenon is seen with very high-titer antibodies in an immune serum. AIM: The prozone effect on anti-D by a low-titer anti-Le(a) was investigated associated with neonatal jaundice. MATERIALS AND METHODS: Standard methods were used in investigations. RESULTS: The child was born at full-term developed mild jaundice. With weak direct antiglobulin test+, her indirect serum bilirubin was progressed to 27...
July 2017: Asian Journal of Transfusion Science
https://www.readbyqxmd.com/read/28952672/long-term-follow-up-of-patients-with-spontaneous-clearance-of-hepatitis-c-does-viral-clearance-mean-cure
#9
M Iqbal, P A McCormick, M Cannon, N Murphy, P Flanagan, J E Kennelly, L Thornton
Up to 40% of patients with hepatitis C virus (HCV) antibodies are negative for HCV RNA at initial evaluation. If there is a risk of viral re-activation, long term follow-up is required with attendant financial, psychological and medical implications. We investigated the risk of re-activation in the Irish anti-D cohort. Information was obtained from the national hepatitis C database which includes data on patients infected by anti-D immunoglobulin in two large outbreaks, 1977-9 and 1991-94. As part of a screening programme, starting in 1994, 64,907 females exposed to anti-D immunoglobulin were evaluated...
June 9, 2017: Irish Medical Journal
https://www.readbyqxmd.com/read/28948523/enhanced-stability-of-gold-magnetic-nanoparticles-with-poly-4-styrenesulfonic-acid-co-maleic-acid-tailored-optical-properties-for-protein-detection
#10
Xiaomei Zhang, Qinlu Zhang, Ting Ma, Qian Liu, Songdi Wu, Kai Hua, Chao Zhang, Mingwei Chen, Yali Cui
Gold magnetic nanoparticles (GoldMag) have attracted great attention due to their unique physical and chemical performances combining those of individual Fe3O4 and Au nanoparticles. Coating GoldMag with polymers not only increases the stability of the composite particles suspended in buffer but also plays a key role for establishing point-of-care optical tests for clinically relevant biomolecules. In the present paper, poly(4-styrenesulfonic acid-co-maleic acid) (PSS-MA), a negatively charged polyelectrolyte with both sulfonate and carboxylate anionic groups, was used to coat the positively charged GoldMag (30 nm) surface...
September 25, 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28926139/the-synonymous-nucleotide-substitution-rhd-1056c-g-alters-mrna-splicing-associated-with-serologically-weak-d-phenotype
#11
Sejong Chun, Jae Won Yun, Geon Park, Duck Cho
BACKGROUND: D antigen is one of the most clinically significant blood group antigens. Variation of the RHD gene can cause weak D or partial D phenotypes. While most variations are missense substitutions with amino acid changes, those without are called "silent" or "synonymous" substitutions. Synonymous substitutions often have little effect on the protein, not altering the phenotype. However, effect on splicing can affect end-product protein. We report a new synonymous variation, RHD 1056C>G, that resulted in weak D phenotype, and predicted its effect with various in silico methods...
September 19, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28923311/colorimetric-detection-of-d-dimer-in-a-paper-based-immunodetection-device
#12
Sónia Ruivo, Ana M Azevedo, Duarte M F Prazeres
A microfluidic paper-based analytical device (μPADs) immunoassay for detection of the blood native biomarker D-dimer is reported. The μPAD is created by wax printing on a single piece of chromatographic paper and combined with an anti-D-dimer capture antibody and conjugates of anti-D-dimer antibody with 40 nm gold nanoparticles. The presence of D-dimer in buffer/simulated plasma samples is successfully reported for concentrations as low as 15 ng D-dimer/mL. Linearity between signal intensity and D-dimer concentration is observed up to 100 ng/mL...
September 15, 2017: Analytical Biochemistry
https://www.readbyqxmd.com/read/28893486/-anti-d-prophylaxis-in-fetal-maternal-erythrocyte-incompatibility-in-tunisia
#13
I Ksibi, R Achour, W Bel Haj Ammar, M Cheour, M Ben Amara, K Neji, S Kacem
Generalization of postnatal prophylaxis using anti-D immunoglobulins decreased the incidence of erythrocyte fetal-maternal incompatibility (EFMI) in the Rhesus system. Few recent studies have investigated the situation of anti-D prophylaxis in Tunisia and its effects on maternal and neonatal health. The aim of this study was therefore to analyze the situation of anti-D prophylaxis in Tunisia to detect defects and propose solutions. We conducted a retrospective descriptive study of IFME cases in the rhesus system in the Department of Medicine and Neonatal Resuscitation of the Tunis Maternity and Neonatology Center (CMNT) during an 8-year period from 1 January 2006 to 31 December 2015...
September 8, 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/28882075/comparative-treatment-related-adverse-event-cost-burden-in-immune-thrombocytopenic-purpura
#14
Prina Z Donga, Sara P Bilir, Gregg Little, Tim Babinchak, Julie Munakata
AIMS: Real-world evidence on the safety profile and costs associated with immune thrombocytopenic purpura (ITP) treatment in adults is lacking. This study quantifies and compares adverse event (AE) crude rates and costs associated with ITP treatments as found in claims data. MATERIALS AND METHODS: A retrospective claims-based analysis was conducted using IMS Pharmetrics Plus database. Included patients were ≥18 years old, with a diagnosis of ITP (2007-2012); an ITP-related claim for anti-D, intravenous immunoglobulin (IVIG), rituximab, romiplostim, or eltrombopag; and 1-year continuous enrollment (3-years for rituximab) during follow-up...
November 2017: Journal of Medical Economics
https://www.readbyqxmd.com/read/28843656/disease-outcomes-in-a-cohort-of-women-in-ireland-infected-by-hepatitis-c-contaminated-anti-d-immunoglobulin-during-1970s
#15
Patricia Garvey, Niamh Murphy, Paula Flanagan, Aline Brennan, Garry Courtney, Orla Crosbie, John Crowe, John Hegarty, John Lee, Margaret McIver, Carol McNulty, Frank Murray, Niamh Nolan, Cliona O'Farrelly, Stephen Stewart, Michele Tait, Suzanne Norris, Lelia Thornton
BACKGROUND & AIM: In the mid-1990s, a group of Rh negative women was diagnosed with hepatitis C virus (HCV) genotype 1b infection, following administration of contaminated anti-D immunoglobulin in 1977-79. We aimed to describe their disease history and estimate the effect of selected host and treatment factors on disease progression. METHODS: We conducted a cohort study on the women infected with HCV. Information was collected from records at seven HCV treatment centres on demographics, treatment and health outcomes up to the 31st December 2013...
December 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28840609/red-blood-cell-alloimmunization-in-pregnancy-during-the-years-1996-2015-in-iceland-a-nation-wide-population-study
#16
Gunnar Bollason, Hulda Hjartardottir, Thorbjorn Jonsson, Sveinn Gudmundsson, Sveinn Kjartansson, Anna Margret Halldorsdottir
BACKGROUND: Red blood cell (RBC) alloimmunization during pregnancy is still a major problem. Historically, anti-D antibodies are most likely to cause severe hemolysis, but other antibodies are also important. In Iceland, postnatal RhIg prophylaxis was implemented in 1969, universal RBC antibody screening was implemented in 1978, but antenatal RhIg prophylaxis is not yet routine. STUDY DESIGN AND METHODS: This nation-wide population study gathered data on alloimmunized pregnancies in Iceland between 1996 and 2015...
August 24, 2017: Transfusion
https://www.readbyqxmd.com/read/28833187/rhd-genotype-and-zygosity-analysis-in-the-chinese-southern-han-d-d-and-d-variant-donors-using-the-multiplex-ligation-dependent-probe-amplification-assay
#17
Y L Ji, H Luo, J Z Wen, L Haer-Wigman, B Veldhuisen, L Wei, Z Wang, P Ligthart, M Lodén-van Straaten, Y S Fu, C E van der Schoot, G P Luo
BACKGROUND AND OBJECTIVES: Several comprehensive genotyping platforms for determining red blood cell (RBC) antigens have been established and validated for use in the Caucasian and Black populations, but not for the Chinese. The multiplex ligation-dependent probe amplification (MLPA) assay was validated for RHD genotyping in the Chinese. MATERIALS AND METHODS: The blood samples of 200 D+, 200 D- and 62 D variant Chinese donors were collected. RhD antigen was routinely typed by serological method...
August 18, 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/28815618/effect-on-gene-expression-of-three-allelic-variants-in-gata-motifs-of-abo-rhd-and-rhce-regulatory-elements
#18
Katie Fennell, Roser Hoffman, Ken Yoshida, Sadahiko Iwamoto, Lavendri Govender, Kuben Vather, Ashika Sookraj, Ute Jentsch, Chantale Pambrun, Catherine McAuley, Margaret A Keller, Gorka Ochoa-Garay
BACKGROUND: Only a few genetic variants have been reported in regulatory elements of blood group genes. Most of them affect GATA motifs, binding sites for the GATA-1 transcription factor. STUDY DESIGN AND METHODS: Samples from two patients and one donor with unusual or discrepant serology for ABO, RhD, and RhCE antigens were analyzed by DNA sequencing. Analyzed regions included the coding sequence and portions of regulatory elements. The effect of some variants on gene expression was evaluated in reporter gene assays...
August 16, 2017: Transfusion
https://www.readbyqxmd.com/read/28796682/a-guide-to-terminology-for-rh-immunoprophylaxis
#19
S Gerald Sandler, John T Queenan
Rh immunoprophylaxis for Rh-negative women requires an understanding of terminology used for Rh blood typing laboratory reports. The pathophysiology of Rh hemolytic disease of the fetus and newborn was elucidated by studies in rhesus monkeys. Subsequent studies revealed that the human blood group antigen responsible for Rh hemolytic disease of the newborn (D antigen) is related to, but different from, the rhesus monkey antigen. Weak expression of the D antigen on red cells, originally termed D, is currently reported by laboratories as a "serologic weak D phenotype," which can be further defined by RHD genotyping to be either a weak D type or a partial D phenotype...
September 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28747221/prevalence-of-heartworm-in-dogs-and-cats-of-madrid-spain
#20
José Alberto Montoya-Alonso, Rodrigo Morchón, Yaiza Falcón-Cordón, Soraya Falcón-Cordón, Fernando Simón, Elena Carretón
BACKGROUND: Dirofilaria immitis causes heartworm disease, a chronic and potentially fatal cardiopulmonary disease which mainly affects dogs and cats. It is present in most of Spain, due to favourable climatic factors. Madrid, located in the centre of the Iberian Peninsula, is the most highly populated city in the country. There is a lack of current data on canine heartworm and there are no published epidemiological data regarding feline heartworm in this region, therefore the aim of this study was to assess the prevalence and current distribution of canine and feline dirofilariosis in the province of Madrid...
July 26, 2017: Parasites & Vectors
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