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https://www.readbyqxmd.com/read/29346430/estimation-of-inhalation-flow-profile-using-audio-based-methods-to-assess-inhaler-medication-adherence
#1
Terence E Taylor, Helena Lacalle Muls, Richard W Costello, Richard B Reilly
Asthma and chronic obstructive pulmonary disease (COPD) patients are required to inhale forcefully and deeply to receive medication when using a dry powder inhaler (DPI). There is a clinical need to objectively monitor the inhalation flow profile of DPIs in order to remotely monitor patient inhalation technique. Audio-based methods have been previously employed to accurately estimate flow parameters such as the peak inspiratory flow rate of inhalations, however, these methods required multiple calibration inhalation audio recordings...
2018: PloS One
https://www.readbyqxmd.com/read/29342050/intraoperative-cochlear-implant-device-testing-utilizing-an-automated-remote-system-a-prospective-pilot-study
#2
Amanda R Lohmann, Matthew L Carlson, Douglas P Sladen
INTRODUCTION: Intraoperative cochlear implant device testing provides valuable information regarding device integrity, electrode position, and may assist with determining initial stimulation settings. Manual intraoperative device testing during cochlear implantation requires the time and expertise of a trained audiologist. The purpose of the current study is to investigate the feasibility of using automated remote intraoperative cochlear implant reverse telemetry testing as an alternative to standard testing...
January 16, 2018: Otology & Neurotology
https://www.readbyqxmd.com/read/29335599/hindlimb-ischemia-impairs-endothelial-recovery-and-increases-neointimal-proliferation-in-the-carotid-artery
#3
Sabato Sorrentino, Claudio Iaconetti, Salvatore De Rosa, Alberto Polimeni, Jolanda Sabatino, Clarice Gareri, Francesco Passafaro, Teresa Mancuso, Laura Tammè, Chiara Mignogna, Caterina Camastra, Giovanni Esposito, Antonio Curcio, Daniele Torella, Ciro Indolfi
Peripheral ischemia is associated with higher degree of endothelial dysfunction and a worse prognosis after percutaneous coronary interventions (PCI). However, the role of peripheral ischemia on vascular remodeling in remote districts remains poorly understood. Here we show that the presence of hindlimb ischemia significantly enhances neointima formation and impairs endothelial recovery in balloon-injured carotid arteries. Endothelial-derived microRNAs are involved in the modulation of these processes. Indeed, endothelial miR-16 is remarkably upregulated after vascular injury in the presences of hindlimb ischemia and exerts a negative effect on endothelial repair through the inhibition of RhoGDIα and nitric oxide (NO) production...
January 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29330677/evaluating-efficacy-of-landsat-derived-environmental-covariates-for-predicting-malaria-distribution-in-rural-villages-of-vhembe-district-south-africa
#4
Oupa E Malahlela, Jane M Olwoch, Clement Adjorlolo
Malaria in South Africa is still a problem despite existing efforts to eradicate the disease. In the Vhembe District Municipality, malaria prevalence is still high, with a mean incidence rate of 328.2 per 100,0000 persons/year. This study aimed at evaluating environmental covariates, such as vegetation moisture and vegetation greenness, associated with malaria vector distribution for better predictability towards rapid and efficient disease management and control. The 2005 malaria incidence data combined with Landsat 5 ETM were used in this study...
January 12, 2018: EcoHealth
https://www.readbyqxmd.com/read/29324314/down-regulation-of-mir-133a-b-in-patients-with-myocardial-infarction-correlates-with-the-presence-of-ventricular-fibrillation
#5
Emanuela Boštjančič, Tanisa Brandner, Nina Zidar, Damjan Glavač, Dušan Štajer
MicroRNAs (miRNAs) are important regulators of physiologic and pathologic conditions of the heart. Animal models of heart diseases have shown that miRNAs may contribute to the development of arrhythmias. However, little is known about the expression of muscle- and cardiac-specific miRNAs in patients with myocardial infarction (MI) who have developed ventricular fibrillation (VF). Our study included 47 patients who had died from myocardial infarction (MI), 23 with clinically proven VF and 24 without VF. Autopsy samples of infarcted tissue and remote myocardium were available (n = 94)...
January 8, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29319315/ruthenium-ii-catalyzed-c-h-hetero-arylation-of-alkenylic-1-n-diazines-n-2-3-and-4-scope-mechanism-and-application-in-tandem-hydrogenations
#6
Rafael Gramage-Doria, Sylvain Achelle, Christian Bruneau, Francoise Robin-le Guen, Vincent Dorcet, Thierry Roisnel
A general ruthenium(II)-catalyzed methodology enabling the (hetero)arylation of alkenylic C-H bonds utilizing a series of synthetically appealing diazines as directing groups is presented. Despite the presence of additional nitrogen lone pairs remote from the C-H bond activation site, which could eventually poison the catalyst, the reaction times are short (3 hours), thus being suitable for selective double C-H bond arylation. Mixtures of E:Z isomeric products were observed in some cases, which were further hydrogenated in a tandem manner in the presence of the remaining ruthenium catalyst from the first step; representing an alternative approach to more difficult C(sp3)-H bond functionalization...
January 10, 2018: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29318397/a-computer-aided-decision-support-system-for-detection-and-localization-of-cutaneous-vasculature-in-dermoscopy-images-via-deep-feature-learning
#7
Pegah Kharazmi, Jiannan Zheng, Harvey Lui, Z Jane Wang, Tim K Lee
Vascular structures of skin are important biomarkers in diagnosis and assessment of cutaneous conditions. Presence and distribution of lesional vessels are associated with specific abnormalities. Therefore, detection and localization of cutaneous vessels provide critical information towards diagnosis and stage status of diseases. However, cutaneous vessels are highly variable in shape, size, color and architecture, which complicate the detection task. Considering the large variability of these structures, conventional vessel detection techniques lack the generalizability to detect different vessel types and require separate algorithms to be designed for each type...
January 9, 2018: Journal of Medical Systems
https://www.readbyqxmd.com/read/29305313/effectiveness-of-the-gocheck-kids-vision-screener-in-detecting-amblyopia-risk-factors
#8
M Millicent W Peterseim, Ryan S Rhodes, Rupa N Patel, M Edward Wilson, Luke E Edmondson, Sarah A Logan, Edward W Cheeseman, Emily Shortridge, Rupal H Trivedi
Effectiveness of the GoCheck Kids Vision Screener in Detecting Amblyopia Risk Factors, MMW Peterseim, RS Rhodes, RN Patel, ME Wilson, LE Edmondson, SA Logan, EW Cheeseman, E Shortridge, RH Trivedi. INTRODUCTION: The GoCheck Kids smartphone photoscreening app (Gobiquity Mobile Health, Scottsdale, Arizona), introduced in 2014, is marketed to pediatricians with little published validation. We wished to evaluate the GoCheck Kids Screener for accuracy in detecting amblyopia risk factors (ARF) using 2013 AAPOS guidelines...
January 2, 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29304165/genetic-diversity-genetic-structure-and-diet-of-ancient-and-contemporary-red-deer-cervus-elaphus-l-from-north-eastern-france
#9
Annik Schnitzler, José Granado, Olivier Putelat, Rose-Marie Arbogast, Dorothée Drucker, Anna Eberhard, Anja Schmutz, Yuri Klaefiger, Gérard Lang, Walter Salzburger, Joerg Schibler, Angela Schlumbaum, Hervé Bocherens
In north-eastern France, red deer (Cervus elaphus L.) populations were rebuilt from a few hundred individuals, which have subsisted in remote valleys of the Vosges mountains, and to a lesser extent from individuals escaped from private enclosures; at present times, this species occupies large areas, mainly in the Vosges Mountains. In this study, we examined the population dynamics of red deer in the Vosges Mountains using ancient and contemporary mitochondrial DNA (mtDNA) from 140 samples (23 ancient + 117 modern) spanning the last 7'000 years...
2018: PloS One
https://www.readbyqxmd.com/read/29300518/silicone-oil-migration-into-the-orbit
#10
Sana Ali Bautista, Edward J Wladis, Martha Farber, Naomi S Falk, Paul O Phelps
PURPOSE: To report a case in of intravitreal silicone oil migration into the inferior orbit. Silicone oil tamponade is commonly used in retinal detachment repair and extrusion into the orbital tissues is very rare. METHODS: A 70-year-old male with a remote history of repair of a right ruptured globe and retinal detachment surgery presented with progressive right lower eyelid edema. There was a known history of intravitreal silicone oil instillation and removal. An elective right inferior orbitotomy with excisional biopsy was performed...
January 4, 2018: Orbit
https://www.readbyqxmd.com/read/29296677/chemoselective-aliphatic-c-h-bond-oxidation-enabled-by-polarity-reversal
#11
Valeria Dantignana, Michela Milan, Olaf Cussó, Anna Company, Massimo Bietti, Miquel Costas
Methods for selective oxidation of aliphatic C-H bonds are called on to revolutionize organic synthesis by providing novel and more efficient paths. Realization of this goal requires the discovery of mechanisms that can alter in a predictable manner the innate reactivity of these bonds. Ideally, these mechanisms need to make oxidation of aliphatic C-H bonds, which are recognized as relatively inert, compatible with the presence of electron rich functional groups that are highly susceptible to oxidation. Furthermore, predictable modification of the relative reactivity of different C-H bonds within a molecule would enable rapid diversification of the resulting oxidation products...
December 27, 2017: ACS Central Science
https://www.readbyqxmd.com/read/29286796/buckling-instability-causes-inertial-thrust-for-spherical-swimmers-at-all-scales
#12
Adel Djellouli, Philippe Marmottant, Henda Djeridi, Catherine Quilliet, Gwennou Coupier
Microswimmers, and among them aspirant microrobots, generally have to cope with flows where viscous forces are dominant, characterized by a low Reynolds number (Re). This implies constraints on the possible sequences of body motion, which have to be nonreciprocal. Furthermore, the presence of a strong drag limits the range of resulting velocities. Here, we propose a swimming mechanism which uses the buckling instability triggered by pressure waves to propel a spherical, hollow shell. With a macroscopic experimental model, we show that a net displacement is produced at all Re regimes...
December 1, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29285401/multifunctional-stimuli-responsive-polymer-gated-iron-and-gold-embedded-silica-nano-golf-balls-nanoshuttles-for-targeted-on-demand-theranostics
#13
Liping Wang, Grace Jang, Deependra Kumar Ban, Vrinda Sant, Jay Seth, Sami Kazmi, Nirav Patel, Qingqing Yang, Joon Lee, Woraphong Janetanakit, Shanshan Wang, Brian P Head, Gennadi Glinsky, Ratneshwar Lal
Multi-functional nanoshuttles for remotely targeted and on-demand delivery of therapeutic molecules and imaging to defined tissues and organs hold great potentials in personalized medicine, including precise early diagnosis, efficient prevention and therapy without toxicity. Yet, in spite of 25 years of research, there are still no such shuttles available. To this end, we have designed magnetic and gold nanoparticles (NP)-embedded silica nanoshuttles (MGNSs) with nanopores on their surface. Fluorescently labeled Doxorubicin (DOX), a cancer drug, was loaded in the MGNSs as a payload...
2017: Bone Research
https://www.readbyqxmd.com/read/29277555/distribution-of-bat-borne-viruses-and-environment-patterns
#14
Aneta Afelt, Audrey Lacroix, Urszula Zawadzka-Pawlewska, Wojciech Pokojski, Philippe Buchy, Roger Frutos
Environmental modifications are leading to biodiversity changes, loss and habitat disturbance. This in turn increases contacts between wildlife and hence the risk of transmission and emergence of zoonotic diseases. We analyzed the environment and land use using remote spatial data around the sampling locations of bats positive for coronavirus (21 sites) and astrovirus (11 sites) collected in 43 sites. A clear association between viruses and hosts was observed. Viruses associated to synanthropic bat genera, such as Myotis or Scotophilus were associated to highly transformed habitats with human presence while viruses associated to fruit bat genera were correlated with natural environments with dense forest, grassland areas and regions of high elevation...
December 22, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/29242859/experimental-evidence-of-charged-domain-walls-in-lead-free-ferroelectric-ceramics-light-driven-nanodomain-switching
#15
Fernando Rubio-Marcos, Adolfo Del Campo, Rocío E Rojas-Hernandez, Mariola O Ramírez, Rodrigo Parra, Rodrigo U Ichikawa, Leandro A Ramajo, Luisa E Bausá, Jose F Fernández
The control of ferroelectric domain walls at the nanometric level leads to novel interfacial properties and functionalities. In particular, the comprehension of charged domain walls, CDWs, lies at the frontier of future nanoelectronic research. Whereas many of the effects have been demonstrated for ideal archetypes, such as single crystals, and/or thin films, a similar control of CDWs on polycrystalline ferroelectrics has not been achieved. Here, we unambiguously show the presence of charged domain walls on a lead-free (K,Na)NbO3 polycrystalline system...
December 15, 2017: Nanoscale
https://www.readbyqxmd.com/read/29239555/analytical-report-of-the-2016-dengue-outbreak-in-c%C3%A3-rdoba-city-argentina
#16
Camilo Rotela, Laura Lopez, María Frías Céspedes, Gabriela Barbas, Andrés Lighezzolo, Ximena Porcasi, Mario A Lanfri, Carlos M Scavuzzo, David E Gorla
After elimination of the Aedes aegypti vector in South America in the 1960s, dengue outbreaks started to reoccur during the 1990s; strongly in Argentina since 1998. In 2016, Córdoba City had the largest dengue outbreak in its history. In this article we report this outbreak including spatio-temporal analysis of cases and vectors in the city. A total of 653 dengue cases were recorded by the laboratory-based dengue surveillance system and georeferenced by their residential addresses. Case maps were generated from the epidemiological week 1 (beginning of January) to week 19 (mid-May)...
November 6, 2017: Geospatial Health
https://www.readbyqxmd.com/read/29235438/acoustic-stimulation-can-induce-a-selective-neural-network-response-mediated-by-piezoelectric-nanoparticles
#17
Camilo Andres Rojas Cifuentes, Mariateresa Tedesco, Paolo Massobrio, Attilio Marino, Gianni Ciofani, Sergio Martinoia, Roberto Raiteri
OBJECTIVE: We aim at developing novel non-invasive or minimally invasive methods for neural stimulation to be applied in the study and treatment of brain (dys)functions and neurological disorders. APPROACH: We investigate the electrophysiological response of in vitro neuronal networks when subjected to low intensity pulsed acoustic stimulation mediated by piezoelectric nanoparticles adsorbed on the neuronal membrane. MAIN RESULTS: We show that the presence of piezoelectric barium titanate nanoparticles induces, in a reproducible way, an increase in the network activity when excited by stationary ultrasound waves in the MHz regime...
December 13, 2017: Journal of Neural Engineering
https://www.readbyqxmd.com/read/29234268/the-evidence-for-the-spread-and-seeding-capacities-of-the-mutant-huntingtin-protein-in-in-vitro-systems-and-their-therapeutic-implications
#18
REVIEW
Maria Masnata, Francesca Cicchetti
Neurodegenerative disorders are not only characterized by specific patterns of cell loss but the presence and accumulation of various pathological proteins-both of which correlate with disease evolution. There is now mounting evidence to suggest that these pathological proteins present with toxic, at times prion-like, properties and can therefore seed pathology in neighboring as well remotely connected healthy neurons as they spread across the brain. What is less clear, at this stage, is how much this actually contributes to, and drives, the core pathogenic events...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29222470/remote-control-of-resistive-switching-in-tio2-based-resistive-random-access-memory-device
#19
Dwipak Prasad Sahu, S Narayana Jammalamadaka
We report on the magnetic field control of a bipolar resistive switching in Ag/TiO2/FTO based resistive random access memory device through I-V characteristics. Essentially, in the presence of magnetic field and in the low resistance state, an abrupt change in the resistance of the device demands higher voltage, hinting that residual Lorentz force plays a significant role in controlling the resistance state. Endurance characteristics of the device infer that there is no degradation of the device even after repeated cycling, which ensures that the switching of resistance between 'off' and 'on' states is reproducible, reversible and controllable...
December 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29220506/a-molecular-portrait-of-de-novo-genes-in-yeasts
#20
Nikolaos N Vakirlis, Alex S Hebert, Dana A Opulente, Guillaume Achaz, Chris Todd Hittinger, Gilles Fischer, Joshua J Coon, Ingrid Lafontaine
New genes, with novel protein functions, can evolve "from scratch" out of intergenic sequences. These de novo genes can integrate the cell's genetic network and drive important phenotypic innovations. Therefore, identifying de novo genes and understanding how the transition from noncoding to coding occurs are key problems in evolutionary biology. However, identifying de novo genes is a difficult task, hampered by the presence of remote homologs, fast evolving sequences and erroneously annotated protein coding genes...
December 6, 2017: Molecular Biology and Evolution
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