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https://www.readbyqxmd.com/read/29245182/an-efficient-parallel-simulation-of-unsteady-blood-flows-in-patient-specific-pulmonary-artery
#1
Fande Kong, Vitaly Kheyfets, Ender Finol, Xiao-Chuan Cai
Simulation of blood flows in the pulmonary artery provides some insight into certain diseases by examining the relationship between some continuum metrics, e.g. the wall shear stress acting on the vascular endothelium, which responds to flow-induced mechanical forces by releasing vasodilators/constrictors. In [?kheyfets2015patient], V. Kheyfets studies numerically a patient-specific pulmonary circulation to show that decreasing wall shear stress is correlated with increasing pulmonary vascular impedance. In this paper, we develop a scalable parallel algorithm based on domain decomposition methods to investigate an unsteady model with patient specific pulsatile waveforms as the inlet boundary condition...
December 15, 2017: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/29244869/lspr-mediated-high-axial-resolution-fluorescence-imaging-on-a-silver-nanoparticle-sheet
#2
Eiji Usukura, Yuhki Yanase, Ayumi Ishijima, Thasaneeya Kuboki, Satoru Kidoaki, Koichi Okamoto, Kaoru Tamada
This paper reports our original technique for visualizing cell-attached nanointerfaces with extremely high axial resolution using homogeneously excited localized surface plasmon resonance (LSPR) on self-assembled silver nanoparticle sheets. The LSPR sheet can confine and enhance the fluorescence at the nanointerface, which provides high signal-to-noise ratio images of focal adhesion at the cell-attached interface. The advantage of this LSPR-assisted technique is its usability, which provides comparable or higher-quality nanointerfacial images than TIRF microscopy, even under epifluorescence microscopy...
2017: PloS One
https://www.readbyqxmd.com/read/29244748/design-of-new-generation-usable-forms-of-topical-haemostatic-agents-containing-chitosan
#3
Dorota Zielińska, Marcin H Struszczyk, Longina Madej-Kiełbik, Edyta Chmal-Fudali, Magdalena Kucharska, Maria Wiśniewska-Wrona, Kinga Brzoza-Malczewska
Designing usable forms of topical haemostatic agents is the most important activity during the design process, resulting in strengthened functional properties of the final medical devices. This study aimed to propose indications for a research programme based on risk management supporting the development of two usable forms of a topical haemostatic agent: chitosan/alginate lyophilized foam and chitosan/alginate impregnated gauze. Both of the usable forms of the topical haemostatic agent, being the main part of the modified combat gauze, were fabricated using the chitosan/alginate complex...
December 15, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29243500/designing-medical-technology-for-resilience-integrating-health-economics-and-human-factors-approaches
#4
Simone Borsci, Ijeoma Uchegbu, Peter Buckle, Zhifang Ni, Simon Walne, George B Hanna
The slow adoption of innovation into healthcare calls into question the manner of evidence generation for medical technology. This paper identifies potential reasons for this including a lack of attention to human factors, poor evaluation of economic benefits, lack of understanding of the existing healthcare system and a failure to recognise the need to generate resilient products. Areas covered. Recognising a cross-disciplinary need to enhance evidence generation early in a technology's life cycle, the present paper proposes a new approach that integrates human factors and health economic evaluation as part of a wider systems approach to the design of technology...
December 15, 2017: Expert Review of Medical Devices
https://www.readbyqxmd.com/read/29243038/what-performance-analysts-need-to-know-about-research-trends-in-association-football-2012-2016-a-systematic-review
#5
REVIEW
Hugo Sarmento, Filipe Manuel Clemente, Duarte Araújo, Keith Davids, Allistair McRobert, António Figueiredo
BACKGROUND: Evolving patterns of match analysis research need to be systematically reviewed regularly since this area of work is burgeoning rapidly and studies can offer new insights to performance analysts if theoretically and coherently organized. OBJECTIVE: The purpose of this paper was to conduct a systematic review of published articles on match analysis in adult male football, identify and organize common research topics, and synthesize the emerging patterns of work between 2012 and 2016, according to the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines...
December 14, 2017: Sports Medicine
https://www.readbyqxmd.com/read/29242833/put3-positively-regulates-proline-utilization-in-candida-albicans
#6
Walters Aji Tebung, Raha Parvizi Omran, Debra L Fulton, Joachim Morschhäuser, Malcolm Whiteway
The zinc cluster transcription factor Put3 was initially characterized in Saccharomyces cerevisiae as the transcriptional activator of PUT1 and PUT2, two genes acting early in the proline assimilation pathway. We have used phenotypic studies, transcription profiling, and chromatin immunoprecipitation with microarray technology (ChIP-chip) to establish that unlike S. cerevisiae, which only uses proline as a nitrogen source, Candida albicans can use proline as a nitrogen source, a carbon source, or a source of both nitrogen and carbon...
November 2017: MSphere
https://www.readbyqxmd.com/read/29242619/instagram-flickr-or-twitter-assessing-the-usability-of-social-media-data-for-visitor-monitoring-in-protected-areas
#7
Henrikki Tenkanen, Enrico Di Minin, Vuokko Heikinheimo, Anna Hausmann, Marna Herbst, Liisa Kajala, Tuuli Toivonen
Social media data is increasingly used as a proxy for human activity in different environments, including protected areas, where collecting visitor information is often laborious and expensive, but important for management and marketing. Here, we compared data from Instagram, Twitter and Flickr, and assessed systematically how park popularity and temporal visitor counts derived from social media data perform against high-precision visitor statistics in 56 national parks in Finland and South Africa in 2014. We show that social media activity is highly associated with park popularity, and social media-based monthly visitation patterns match relatively well with the official visitor counts...
December 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29242180/development-and-usability-evaluation-of-an-art-and-narrative-based-knowledge-translation-tool-for-parents-with-a-child-with-pediatric-chronic-pain-multi-method-study
#8
Kathy Reid, Lisa Hartling, Samina Ali, Anne Le, Allison Norris, Shannon D Scott
BACKGROUND: Chronic pain in childhood is increasingly being recognized as a significant clinical problem for children and their families. Previous research has identified that families want information about the causes of their child's chronic pain, treatment options, and effective strategies to help their child cope with the pain. Unfortunately, parents have reported that finding this information can be challenging. OBJECTIVE: The aim of this study was to actively work together with children attending a pediatric chronic pain clinic and their parents to develop, refine, and evaluate the usability of an art and narrative-based electronic book (e-book) for pediatric chronic pain...
December 14, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/29242178/deciding-how-to-stay-independent-at-home-in-later-years-development-and-acceptability-testing-of-an-informative-web-based-module
#9
Mirjam Marjolein Garvelink, C Allyson Jones, Patrick M Archambault, Noémie Roy, Louisa Blair, France Légaré
BACKGROUND: Seniors with loss of autonomy may face decisions about whether they should stay at home or move elsewhere. Most seniors would prefer to stay home and be independent for as long as possible, but most are unaware of options that would make this possible. OBJECTIVE: The study aimed to develop and test the acceptability of an interactive website for seniors, their caregivers, and health professionals with short interlinked videos presenting information about options for staying independent at home...
December 14, 2017: JMIR Human Factors
https://www.readbyqxmd.com/read/29241901/comparison-of-timed-automata-with-discrete-event-simulation-for-modeling-of-biomarker-based-treatment-decisions-an-illustration-for-metastatic-castration-resistant-prostate-cancer
#10
Koen Degeling, Stefano Schivo, Niven Mehra, Hendrik Koffijberg, Rom Langerak, Johann S de Bono, Maarten J IJzerman
BACKGROUND: With the advent of personalized medicine, the field of health economic modeling is being challenged and the use of patient-level dynamic modeling techniques might be required. OBJECTIVES: To illustrate the usability of two such techniques, timed automata (TA) and discrete event simulation (DES), for modeling personalized treatment decisions. METHODS: An early health technology assessment on the use of circulating tumor cells, compared with prostate-specific antigen and bone scintigraphy, to inform treatment decisions in metastatic castration-resistant prostate cancer was performed...
December 2017: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/29241250/health-it-usability-focus-section-adapting-ehr-based-medication-instructions-to-comply-with-plain-language-guidance-a-randomized-experiment
#11
Jessica S Ancker, Alexander Send, Baria Hafeez, Snezana N Osorio, Erika Abramson
No abstract text is available yet for this article.
October 2017: Applied Clinical Informatics
https://www.readbyqxmd.com/read/29241249/health-it-usability-focus-section-data-use-and-navigation-patterns-among-medical-icu-clinicians-during-electronic-chart-review
#12
Matthew E Nolan, Rizwan Siwani, Haytham Helmi, Brian W Pickering, Pablo Moreno-Franco, Vitaly Herasevich
No abstract text is available yet for this article.
October 2017: Applied Clinical Informatics
https://www.readbyqxmd.com/read/29241247/usability-evaluation-of-electronic-health-record-system-around-clinical-notes-usage-an-ethnographic-study
#13
Rubina F Rizvi, Jenna L Marquard, Gretchen M Hultman, Terrence J Adam, Kathleen A Harder, Genevieve B Melton
No abstract text is available yet for this article.
October 2017: Applied Clinical Informatics
https://www.readbyqxmd.com/read/29241245/better-usability-and-technical-stability-could-lead-to-better-work-related-well-being-among-physicians
#14
Suvi Vainiomäki, Anna-Mari Aalto, Tinja Lääveri, Timo Sinervo, Marko Elovainio, Pekka Mäntyselkä, Hannele Hyppönen
No abstract text is available yet for this article.
October 2017: Applied Clinical Informatics
https://www.readbyqxmd.com/read/29240608/metabolic-profile-of-ex-vivo-lung-perfusate-yields-biomarkers-for-lung-transplant-outcomes
#15
Michael K Hsin, Ricardo Zamel, Marcelo Cypel, David Wishart, Beomsoo Han, Shaf Keshavjee, Mingyao Liu
OBJECTIVE: To identify potential biomarkers during ex vivo lung perfusion (EVLP) using metabolomics approach. SUMMARY BACKGROUND DATA: EVLP increases the number of usable donor lungs for lung transplantation (LTx) by physiologic assessment of explanted marginal lungs. The underlying paradigm of EVLP is the normothermic perfusion of cadaveric lungs previously flushed and stored in hypothermic preservation fluid, which allows the resumption of active cellular metabolism and respiratory function...
January 2018: Annals of Surgery
https://www.readbyqxmd.com/read/29239763/the-tourniquet-gap-a-pilot-study-of-the-intuitive-placement-of-three-tourniquet-types-by-laypersons
#16
Elliot M Ross, Julian G Mapp, Theodore T Redman, Derek J Brown, Chetan U Kharod, David A Wampler
BACKGROUND: The "Stop the Bleed" campaign in the United States advocates for nonmedical personnel to be trained in basic hemorrhage control and that "bleeding control kits" be available in high-risk areas. However, it is not clear which tourniquets are most effective in the hands of laypersons. OBJECTIVES: The objective of this pilot study was to determine which tourniquet type was the most intuitive for a layperson to apply correctly. METHODS: This project is a randomized study derived from a "Stop the Bleed" education initiative conducted between September 2016 and March 2017...
November 24, 2017: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29239707/immigration-psychic-dislocation-and-the-re-creation-of-community
#17
Ricardo C Ainslie
Communities are "psychic entities" that serve powerful psychological functions for the individuals living within them. They also serve multiple functions, including as a potential space where individuals are "held" and within which individuals "play" in ways akin to Winnicott's formulations regarding how infants "use" the me-not-me zone of experiencing, the potential space created by the gap between symbiotic engagement and the maternal object, in a zone between desire for fusion and fear of disintegrating abandonment...
December 2017: Psychoanalytic Review
https://www.readbyqxmd.com/read/29238422/electronic-questionnaires-design-and-implementation
#18
REVIEW
Clara Minto, Giulia Beltrame Vriz, Matteo Martinato, Dario Gregori
Background: Nursing and health care research are increasingly using e-questionnaires and e-forms for data collection and survey conduction. The main reason lies in costs, time and data-entry errors containment, increased flexibility, functionality and usability. In spite of this growing usage, no specifc and comprehensive guidelines for designing and submitting e-questionnaires have been produced so far. Objective: The aim of this review is to collect information on the current best practices, taking them from various fields of application...
2017: Open Nursing Journal
https://www.readbyqxmd.com/read/29237856/humans-as-model-organisms
#19
Kim Sterelny
Like every other species, our species is the result of descent with modification under the influence of natural selection; a tip in an increasingly large and deep series of nested clades, as we trace its ancestry back to increasingly remote antecedents. As a consequence of shared history, our species has much in common with many others; as a consequence of its production by the general mechanisms of evolution, our species carries information about the mechanisms that shaped other species as well. For reasons unconnected to biological theory, we have far more information about humans than we do about other species...
December 20, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/29237581/a-web-based-training-resource-for-therapists-to-deliver-an-evidence-based-exercise-program-for-rheumatoid-arthritis-of-the-hand-isarah-design-development-and-usability-testing
#20
Cynthia Swarnalatha Srikesavan, Esther Williamson, Lucy Eldridge, Peter Heine, Jo Adams, Tim Cranston, Sarah E Lamb
BACKGROUND: The Strengthening and Stretching for Rheumatoid Arthritis of the Hand (SARAH) is a tailored, progressive exercise program for people having difficulties with wrist and hand function due to rheumatoid arthritis (RA). The program was evaluated in a large-scale clinical trial and was found to improve hand function, was safe to deliver, and was cost-effective. These findings led to the SARAH program being recommended in the UK National Institute for Health and Care Excellence guidelines for the management of adults with RA...
December 13, 2017: Journal of Medical Internet Research
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