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https://www.readbyqxmd.com/read/29679829/fulfilling-spawning-flow-requirements-for-potamodromous-cyprinids-in-a-restored-river-segment
#1
Isabel Boavida, Joaquim B Jesus, Vítor Pereira, Cátia Santos, Marisa Lopes, Rui M V Cortes
The Baixo Sabor hydroelectric scheme was recently constructed (began operating in 2015), blocking fish migration immediately at the river mouth. As a compensation measure for spawning habitat loss the Vilariça River which confluences with Sabor River, immediately downstream from the Baixo Sabor scheme, was chosen for rehabilitation site as an attempt to replace the spawning grounds lost in Sabor River for the potamodromous cyprinid Iberian barbel (Luciobarbus bocagei). Restoration activities included: placement of submerged weirs with fish ramps to increase the lotic/lentic sequence, bank reinforcement, boulder placement and river water profile increase...
April 18, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29679647/a-new-micro-holder-device-for-local-drug-delivery-during-in-vivo-whole-cell-recordings
#2
María Sáez, Maya Ketzef, Javier Alegre-Cortés, Ramón Reig, Gilad Silberberg
Focal administration of pharmacological agents during in vivo recordings is a useful technique to study the functional properties of neural microcircuits. However, the lack of visual control makes this task difficult and inaccurate, especially when targeting small and deep regions where spillover to neighboring regions is likely to occur. An additional problem with recording stability arises when combining focal drug administration with in vivo intracellular recordings, which are highly sensitive to mechanical vibrations...
April 18, 2018: Neuroscience
https://www.readbyqxmd.com/read/29679606/regulatory-pitfalls-and-opportunities-when-repurposing-for-inhalation-therapy
#3
Svetlana Lyapustina
This article reviews regulatory considerations for companies wishing to develop drugs for delivery via the respiratory tract (e.g., by oral inhalation or intranasally) using molecules previously approved for a different therapeutic indication and/or a different delivery route. Conceptually, such repurposing has many medical and business advantages, but turning promising ideas into real products requires overcoming a number of practical challenges. Obtaining regulatory approval to market a candidate product comes at the end of a product development, but being aware of the regulatory requirements is necessary before the development even starts...
April 18, 2018: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/29678989/prescribing-and-deprescribing-antihypertensive-medication-in-older-people-by-dutch-general-practitioners-a-qualitative-study
#4
Tessa van Middelaar, Sophie D Ivens, Petra G van Peet, Rosalinde K E Poortvliet, Edo Richard, A Jeannette Pols, Eric P Moll van Charante
OBJECTIVES: To explore general practitioners' (GPs) routines and considerations on (de)prescribing antihypertensive medication (AHM) in older patients, their judgement on usability of the current guideline and needs for future support. DESIGN: Semistructured interviews. SETTING: Dutch general practice. PARTICIPANTS: Fifteen GPs were purposively sampled based on level of experience and practice characteristics until saturation was reached...
April 20, 2018: BMJ Open
https://www.readbyqxmd.com/read/29678848/circulating-rbp4-increase-and-its-diagnosis-of-chronic-kidney-disease
#5
Chunhua Xun, Yong Zhao, Wenjuan Wang, Changming Chen
OBJECTIVE: Sera retinol binding protein 4 (RBP4) has been associated with renal function. We determined the concentration of sera RBP4 in chronic kidney disease (CKD) and found its diagnostic value for CKD. MATERIALS AND METHODS: The sera samples were collected from 51 patients with CKD and 30 healthy control. The presence of circulating RBP4 was quantified by Enzyme-linked immunosorbent assay (ELISA), cystain C (CysC), urea, creatinine (CREA), uric acid (UA), total protein (TP), albumin (ALB) and 24 hours urinary protein (PRO) were examined by automatic biochemical analyzer...
March 2018: Annals of Clinical and Laboratory Science
https://www.readbyqxmd.com/read/29678804/feasibility-and-acceptability-of-a-web-based-treatment-with-telephone-support-for-postpartum-women-with-anxiety-randomized-controlled-trial
#6
Miriam T Ashford, Ellinor K Olander, Heather Rowe, Jane Rw Fisher, Susan Ayers
BACKGROUND: Postpartum anxiety can have adverse effects on the mother and child if left untreated. Time constraints and stigma are common barriers to postpartum treatment. Web-based treatments offer potential flexibility and anonymity. What Am I Worried About (WaWa) is a self-guided treatment based on cognitive-behavioral and mindfulness principles for women experiencing postpartum anxiety. WaWa was developed in Australia and consists of 9 modules with optional weekly telephone support...
April 20, 2018: JMIR Mental Health
https://www.readbyqxmd.com/read/29678080/intercoder-reliability-of-mapping-between-pharmaceutical-dose-forms-in-the-german-medication-plan-and-edqm-standard-terms
#7
Julian Sass, Kim Becker, Dominik Ludmann, Elisabeth Pantazoglou, Heike Dewenter, Sylvia Thun
A nationally uniform medication plan has recently been part of German legislation. The specification for the German medication plan was developed in cooperation between various stakeholders of the healthcare system. Its' goal is to enhance usability and interoperability while also providing patients and physicians with the necessary information they require for a safe and high-quality therapy. Within the research and development project named Medication Plan PLUS, the specification of the medication plan was tested and reviewed for semantic interoperability in particular...
2018: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29678073/a-decision-support-tool-for-healthcare-professionals-in-the-management-of-hyperphosphatemia-in-hemodialysis
#8
Sisse H Laursen, Amanda A Buus, Lisbet Brandi, Peter Vestergaard, Ole K Hejlesen
Hyperphosphatemia is known as one of the more challenging conditions in end-stage renal disease patients. This study set out to present and evaluate a healthcare-oriented decision support tool in the management of hyperphosphatemia within hemodialysis therapy. A prototype module was designed to fit into the interface of a modern dialysis machine (Fresenius 5008). The prototype included three main functions: 1) immediate bedside blood sample access, 2) a model based prognosis tool with estimates of P-phosphate and 3) an overview of the user's phosphate related activities during dialysis treatments...
2018: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29678066/older-adults-co-creating-meaningful-individualized-social-activities-online-for-healthy-ageing
#9
Madeleine Blusi, Ingeborg Nilsson, Helena Lindgren
Social isolation and loneliness among older people is a growing problem with negative effects on physical and mental health. In co-creation with older adults individualized social activities were designed where older adults through computer mediated communication were able to participate in social activities without leaving their homes. Four types of activities were designed; outdoor activity, music event, visiting a friend and leisure activity. A participatory action research design was applied, where end users together with scientists from two research fields developed, tested and evaluated online participation in the activities...
2018: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29678065/making-the-care-comprehensive-geriatric-assessment-as-the-core-of-a-total-mobile-long-term-care-support-system-in-china
#10
Yanyan Cui, Dongwei Gong, Bo Yang, Hua Chen, Ming-Hsiang Tu, Chaonan Zhang, Huan Li, Naiwen Liang, Liping Jiang, Polun Chang
Comprehensive Geriatric Assessments (CGAs) have been recommended to be used for better monitoring the health status of elder residents and providing quality care. This study reported how our nurses perceived the usability of CGA component of a mobile integrated-care long term care support system developed in China. We used the Continuity Assessment Record and Evaluation (CARE), developed in the US, as the core CGA component of our Android-based support system, in which apps were designed for all key stakeholders for delivering quality long term care...
2018: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29678064/engaging-stakeholders-in-the-design-and-usability-evaluation-of-a-decision-aid-to-improve-secondary-stroke-prevention
#11
Talya Porat, Zhining Liao, Vasa Curcin
Stroke survivors have a nearly 40% risk of recurrent stroke during the first 10 years. Effective secondary stroke prevention strategies are sub-optimally used, and hence, developing interventions to enable healthcare professionals and stroke survivors to manage risk factors more effectively are required. In this paper we describe the usability evaluation of a decision aid designed in collaboration with stakeholders to reduce the risk of a recurrent stroke. The decision aid was found usable and acceptable by both general practitioners and stroke survivors...
2018: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29678041/the-reliability-of-using-tablet-technology-for-screening-the-health-of-older-adults
#12
Lex van Velsen, Sanne Frazer, Aurèle N'dja, Nadir Ammour, Susanna Del Signore, Gianluca Zia, Hermie Hermens
In this study, we assessed the reliability of using a tablet application for collecting health data among older adults, in comparison to using paper surveys for this goal. Test-retest reliability between the two modalities, usability, user experience factors, and older adults' preference were determined. The results show perfect agreement between tablet and paper for the SARC-F and high agreement for the SF-36 physical scale and EQ-5D. Usability and user experience factors were perceived the same for both modalities...
2018: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29678012/acceptance-of-a-mobile-application-supporting-nurses-workflow-at-patient-bedside-results-from-a-pilot-study
#13
Frederic Ehrler, Pascal Ducloux, Danny T Y Wu, Christian Lovis, Katherine Blondon
Supporting caregivers' workflow with mobile applications (apps) is a growing trend. At the bedside, apps can provide new ways to support the documentation process rather than using a desktop computer in a nursing office. Although these applications show potential, few existing reports have studied the real impact of such solutions. At the University Hospitals of Geneva, we developed BEDside Mobility, a mobile application supporting nurses' daily workflow. In a pilot study, the app was trialed in two wards for a period of one month...
2018: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29678010/move-a-mobile-app-designed-for-social-health-relations-in-residential-areas
#14
Anne Marie Kanstrup, Pernille Bertelsen, Heilyn Camacho Nunez, Tanja Svarre, Jan Stage
This paper describes the design of MOVE, a mobile app to support people in forming social relations around exercise in residential areas. MOVE was developed in collaboration with residents and health professionals in a neighbourhood identified as a high-risk health area. The app is targeted to those who are motivated but challenged to do exercise and based on a conceptual model to provide users a social horizon of exercise activities in their residential area. We present the design and first evaluation of MOVE, including usability evaluations in controlled and natural settings...
2018: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29678004/user-evaluation-of-a-smartphone-application-for-anticoagulation-therapy
#15
Berglind Smaradottir, Santiago Martinez, Elizabeth Borycki, Gareth Loudon, Andre Kushniruk, Jarle Jortveit, Rune Fensli
Anticoagulation therapy with Warfarin is used for specific cardiovascular diseases to control the ability of blood clotting. Traditional ways of self-management therapy are based on paper forms and procedures. This paper presents an evaluation of the smartphone application Warfarin Guide, a computer-assisted decision-support system used to help patients in their management of anticoagulation therapy related to International Normalized Ratio (INR) values. The evaluation consisted of a usability test with 4 participants and a field test with 14 participants who used the application at home during four months...
2018: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29678000/a-framework-for-usability-evaluation-in-ehr-procurement
#16
Mari Tyllinen, Johanna Kaipio, Tinja Lääveri
Usability should be considered already by the procuring organizations when selecting future systems. In this paper, we present a framework for usability evaluation during electronic health record (EHR) system procurement. We describe the objectives of the evaluation, the procedure, selected usability attributes and the evaluation methods to measure them. We also present the emphasis usability had in the selection process. We do not elaborate on the details of the results, the application of methods or gathering of data...
2018: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29677973/yorwalk-desiging-a-smartphone-exercise-application-for-people-with-intermittent-claudication
#17
Ahmed Shalan, Abubakar Abdulrahman, Ibrahim Habli, Garry Tew, Andrew Thompson
Peripheral Arterial Disease (PAD) is a chronic cardiovascular disease. It is highly prevalent in older adults. Mobile Health (mHealth) and Telehealth technologies are considered two central digital solutions for enabling patient-centred care. There is evidence that physical activity apps can improve health outcomes in adults. The aim of this project is to develop a prototype of smart phone app to target patients with PAD, which we named YORwalK, to promote exercise and track changes in walking ability in this population...
2018: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29677928/monitoring-and-benchmarking-ehealth-in-the-nordic-countries
#18
Christian Nøhr, Sabine Koch, Vivian Vimarlund, Heidi Gilstad, Arild Faxvaag, Gudrun Audur Hardardottir, Hege K Andreassen, Maarit Kangas, Jarmo Reponen, Pernille Bertelsen, Sidsel Villumsen, Hannele Hyppönen
The Nordic eHealth Research Network, a subgroup of the Nordic Council of Ministers eHealth group, is working on developing indicators to monitor progress in availability, use and outcome of eHealth applications in the Nordic countries. This paper reports on the consecutive analysis of National eHealth policies in the Nordic countries from 2012 to 2016. Furthermore, it discusses the consequences for the development of indicators that can measure changes in the eHealth environment arising from the policies. The main change in policies is reflected in a shift towards more stakeholder involvement and intensified focus on clinical infrastructure...
2018: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29677925/designing-an-authorization-system-based-on-patient-privacy-preferences-in-japan
#19
Kensuke Morris, Goshiro Yamamoto, Shusuke Hiragi, Shosuke Ohtera, Michi Sakai, Osamu Sugiyama, Kazuya Okamoto, Masayuki Nambu, Tomohiro Kuroda
High accessibility of Electronic Health Record systems can increase usability but creates simultaneously patients' anxieties about privacy issues. In order to reduce the privacy concerns, we focused on control and awareness, and designed an approach that can provide availability of patient's clinical data to doctors in two scenarios; (S1) direct control by the patient when they are conscious, (S2) control by a trusted representative when the patient is unconscious. In this paper, we show further analysis in a survey (n = 310, age range: 19-91) done to test the acceptability of our concept of a using a trusted representative and to further understand the concerns of Japanese citizens to improve our system design...
2018: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29676245/structure-and-interaction-prediction-in-prokaryotic-rna-biology
#20
Patrick R Wright, Martin Mann, Rolf Backofen
Many years of research in RNA biology have soundly established the importance of RNA-based regulation far beyond most early traditional presumptions. Importantly, the advances in "wet" laboratory techniques have produced unprecedented amounts of data that require efficient and precise computational analysis schemes and algorithms. Hence, many in silico methods that attempt topological and functional classification of novel putative RNA-based regulators are available. In this review, we technically outline thermodynamics-based standard RNA secondary structure and RNA-RNA interaction prediction approaches that have proven valuable to the RNA research community in the past and present...
April 2018: Microbiology Spectrum
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