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https://www.readbyqxmd.com/read/29456625/alignment-of-microbial-fitness-with-engineered-product-formation-obligatory-coupling-between-acetate-production-and-photoautotrophic-growth
#1
Wei Du, Joeri A Jongbloets, Coco van Boxtel, Hugo Pineda Hernández, David Lips, Brett G Oliver, Klaas J Hellingwerf, Filipe Branco Dos Santos
Background: Microbial bioengineering has the potential to become a key contributor to the future development of human society by providing sustainable, novel, and cost-effective production pipelines. However, the sustained productivity of genetically engineered strains is often a challenge, as spontaneous non-producing mutants tend to grow faster and take over the population. Novel strategies to prevent this issue of strain instability are urgently needed. Results: In this study, we propose a novel strategy applicable to all microbial production systems for which a genome-scale metabolic model is available that aligns the production of native metabolites to the formation of biomass...
2018: Biotechnology for Biofuels
https://www.readbyqxmd.com/read/29455684/optimizing-usability-of-an-economic-decision-support-tool-prototype-of-the-equipt-tool
#2
Kei Long Cheung, Mickaël Hiligsmann, Maximilian Präger, Teresa Jones, Judit Józwiak-Hagymásy, Celia Muñoz, Adam Lester-George, Subhash Pokhrel, Ángel López-Nicolás, Marta Trapero-Bertran, Silvia M A A Evers, Hein de Vries
OBJECTIVES: Economic decision-support tools can provide valuable information for tobacco control stakeholders, but their usability may impact the adoption of such tools. This study aims to illustrate a mixed-method usability evaluation of an economic decision-support tool for tobacco control, using the EQUIPT ROI tool prototype as a case study. METHODS: A cross-sectional mixed methods design was used, including a heuristic evaluation, a thinking aloud approach, and a questionnaire testing and exploring the usability of the Return of Investment tool...
February 19, 2018: International Journal of Technology Assessment in Health Care
https://www.readbyqxmd.com/read/29455170/comparison-and-validation-of-screening-tools-for-substance-use-in-pregnancy-a-cross-sectional-study-conducted-in-maryland-prenatal-clinics
#3
Victoria H Coleman-Cowger, Emmanuel A Oga, Erica N Peters, Kathleen Trocin, Bartosz Koszowski, Katrina Mark
INTRODUCTION: Prescription-drug use in the USA has increased by more than 60% in the last three decades. Prevalence of prescription-drug use among pregnant women is currently estimated around 50%. Prevalence of illicit drug use in the USA is 14.6% among pregnant adolescents, 8.6% among pregnant young adults and 3.2% among pregnant adults. The first step in identifying problematic drug use during pregnancy is screening; however, no specific substance-use screener has been universally recommended for use with pregnant women to identify illicit or prescription-drug use...
February 17, 2018: BMJ Open
https://www.readbyqxmd.com/read/29454293/health-professions-faculty-beliefs-confidence-use-and-perceptions-of-organizational-culture-and-readiness-for-ebp-a-cross-sectional-descriptive-survey
#4
Kerry A Milner, Holly B Bradley, Tammy Lampley
BACKGROUND: Evidence-based practice (EBP) is an essential skill and ethical obligation for all practicing health professions clinicians because of its strong association with improved health outcomes. Emerging evidence suggests that faculty who prepare these clinicians lack proficiency to teach EBP. OBJECTIVES: The purpose of this study was to describe; 1) health profession faculty beliefs about and confidence in their ability to teach and implement EBP, 2) use of EBP for education, 3) organizational culture and readiness for EBP; and to determine whether relationships exist among these variables...
February 8, 2018: Nurse Education Today
https://www.readbyqxmd.com/read/29453513/simultaneous-cell-disruption-and-lipid-extraction-of-wet-aurantiochytrium-sp-krs101-using-a-high-shear-mixer
#5
Minsoo Kwak, Seul Gi Kang, Won-Kyung Hong, Jong-In Han, Yong Keun Chang
Microalgae are regarded as a promising source of biofuels, and the concept of a microalgae-based biorefinery has attracted increasing attention in recent years. From an economic perspective, however, the process remains far from competitive with fossil fuels. This is particularly true of lipid extraction, due in part to the energy-intensive drying step. As a result, wet extraction methods have been studied as an economic alternative. In the present study, a novel extraction approach which utilizes high shear stress mixing was adopted and demonstrated for simultaneous lipid extraction and cell disruption to enable the retrieval of lipids directly from concentrated wet biomass...
February 16, 2018: Bioprocess and Biosystems Engineering
https://www.readbyqxmd.com/read/29453187/quality-of-web-based-educational-interventions-for-clinicians-on-human-papillomavirus-vaccine-content-and-usability-assessment
#6
Brittany L Rosen, James M Bishop, Skye L McDonald, Jessica A Kahn, Gary L Kreps
BACKGROUND: Human papillomavirus (HPV) vaccination rates fall far short of Healthy People 2020 objectives. A leading reason is that clinicians do not recommend the vaccine consistently and strongly to girls and boys in the age group recommended for vaccination. Although Web-based HPV vaccine educational interventions for clinicians have been created to promote vaccination recommendations, rigorous evaluations of these interventions have not been conducted. Such evaluations are important to maximize the efficacy of educational interventions in promoting clinician recommendations for HPV vaccination...
February 16, 2018: JMIR Cancer
https://www.readbyqxmd.com/read/29448723/preparation-of-nanoscale-zinc-oxide-laponite-composites-by-polyvinyl-alcohol-polymerization-and-usability-for-removal-of-trichloroethylene-in-water
#7
Jong Kyu Kim, Hosang Ahn, Jong-Ho Kim, Yang-Jin Ban, Keugtae Kim, Jin Chul Joo
Innovative nanoscale ZnO-laponite-polyvinyl alcohol composites (NZLPc) were developed as a valid alternative to nanoscale photocatalysts for mineralization of chlorinated hydrocarbons without difficulties in recovery of nanoscale photocatalyst particles. NZLPc were synthesized by mixing nanoscale ZnO particles with laponite in PVA solution, and by crosslinking PVA solution in the presence of boric acid (≥1.6 M). Different mixing ratios of the raw materials were investigated to develop the stable NZLPc, and X-ray diffraction, scanning electron microscopy, energy-dispersive X-ray spectroscopy, and transmission electron microscopy characterizations were performed...
March 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29445730/pilot-study-of-a-smartphone-application-designed-to-socially-motivate-cardiovascular-disease-patients-to-improve-medication-adherence
#8
Saki Fujita, Isaree Pitaktong, Graeme Vosit Steller, Victor Dadfar, Qinwen Huang, Sindhu Banerjee, Richard Guo, Hien Tan Nguyen, Robert Harry Allen, Seth Shay Martin
Background: Social support received by patients from family and community has been identified as a key factor for success in improving medication adherence in those patients. This pilot study aimed to investigate the usability and feasibility of PillPal, a smartphone application that uses video-chatting as a social motivation medium to encourage medication adherence in cardiovascular disease (CVD) patients. We additionally gathered feedback on the Physician Calendar, an accompanying web platform that allows clinicians to view patient adherence data generated from the app...
2018: MHealth
https://www.readbyqxmd.com/read/29444661/rna-qc-chain-comprehensive-and-fast-quality-control-for-rna-seq-data
#9
Qian Zhou, Xiaoquan Su, Gongchao Jing, Songlin Chen, Kang Ning
BACKGROUND: RNA-Seq has become one of the most widely used applications based on next-generation sequencing technology. However, raw RNA-Seq data may have quality issues, which can significantly distort analytical results and lead to erroneous conclusions. Therefore, the raw data must be subjected to vigorous quality control (QC) procedures before downstream analysis. Currently, an accurate and complete QC of RNA-Seq data requires of a suite of different QC tools used consecutively, which is inefficient in terms of usability, running time, file usage, and interpretability of the results...
February 14, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29442335/early-assessment-of-the-likely-cost-effectiveness-of-single-use-flexible-video-bronchoscopes
#10
Christoffer Lilja Terjesen, Julia Kovaleva, Lars Ehlers
BACKGROUND: Bronchoscopic procedures are common in the clinical setting, with estimates indicating 500,000 are undertaken per year in the USA alone. These procedures are generally regarded as safe. Unfortunately, a risk of cross-contamination between patients, with possible subsequent infection, is associated with the re-usable technology typically used in these procedures. OBJECTIVE: Our objective was to conduct an early cost-effectiveness analysis (CEA) of single-use flexible video bronchoscope technology compared with the current reusable technology in a US hospital intensive care setting...
June 2017: PharmacoEconomics Open
https://www.readbyqxmd.com/read/29442163/accuracy-and-feasibility-of-a-dedicated-image-guidance-solution-for-endoscopic-lateral-skull-base-surgery
#11
Christoph Rathgeb, Lukas Anschuetz, Daniel Schneider, Cilgia Dür, Marco Caversaccio, Stefan Weber, Tom Williamson
OBJECTIVE: We aimed to design, build and validate a surgical navigation system which fulfills the accuracy requirements for surgical procedures on the ear and the lateral skull base, and which integrates with the endoscopic workflow and operating room setup. MATERIALS AND METHODS: The navigation system consists of portable tablet computer (iPad Pro, Apple Computer, USA) and an optical tracking system (Cambar B1, Axios3D, Germany), both connected via a wireless Bluetooth link and attached directly to the OR table...
February 13, 2018: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29441756/three-software-tools-for-viewing-sectional-planes-volume-models-and-surface-models-of-a-cadaver-hand
#12
Beom Sun Chung, Min Suk Chung, Byeong Seok Shin, Koojoo Kwon
BACKGROUND: The hand anatomy, including the complicated hand muscles, can be grasped by using computer-assisted learning tools with high quality two-dimensional images and three-dimensional models. The purpose of this study was to present up-to-date software tools that promote learning of stereoscopic morphology of the hand. METHODS: On the basis of horizontal sectioned images and outlined images of a male cadaver, vertical planes, volume models, and surface models were elaborated...
February 19, 2018: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/29441642/lycra-splinting-garments-for-adults-with-intellectual-disabilities-who-fall-due-to-gait-or-balance-issues-a-feasibility-study
#13
J Finlayson, J Crockett, S Shanmugam, B Stansfield
BACKGROUND: Adults with intellectual disabilities (IDs) experience high rates of falls and have high rates of gait or balance issues which contribute to falls. Lycra splinting garments (LSGs) have potential to improve gait or balance, but they have never before been tested with adults with IDs who fall due to gait or balance issues. The aim of this study was to test in adults with IDs, the feasibility of using LSGs to improve movement and function and reduce falls, whilst also exploring usability and likely compliance...
February 14, 2018: Journal of Intellectual Disability Research: JIDR
https://www.readbyqxmd.com/read/29439863/towards-the-enhancement-of-body-standing-balance-recovery-by-means-of-a-wireless-audio-biofeedback-system
#14
Giovanni Costantini, Daniele Casali, Fabio Paolizzo, Marco Alessandrini, Alessandro Micarelli, Andrea Viziano, Giovanni Saggio
Human maintain their body balance by sensorimotor controls mainly based on information gathered from vision, proprioception and vestibular systems. When there is a lack of information, caused by pathologies, diseases or aging, the subject may fall. In this context, we developed a system to augment information gathering, providing the subject with warning audio-feedback signals related to his/her equilibrium. The system comprises an inertial measurement unit (IMU), a data processing unit, a headphone audio device and a software application...
February 10, 2018: Medical Engineering & Physics
https://www.readbyqxmd.com/read/29439286/evidence-flowers-an-innovative-visual-method-of-presenting-best-evidence-summaries-to-health-professional-and-lay-audiences
#15
O O Babatunde, V Tan, J L Jordan, K Dziedzic, C A Chew-Graham, C Jinks, J Protheroe, D A van der Windt
BACKGROUND & AIMS: Barriers to dissemination and engagement with evidence pose a threat to implementing evidence-based medicine. Understanding, retention and recall can be enhanced by visual presentation of information. The aim of this exploratory research was to develop and evaluate the accessibility and acceptability of visual summaries for presenting evidence syntheses with multiple exposures or outcomes to professional and lay audiences. METHODS: 'Evidence flowers' were developed as a visual method of presenting data from four case scenarios: two complex evidence syntheses with multiple outcomes, Cochrane reviews and clinical guidelines...
February 13, 2018: Research Synthesis Methods
https://www.readbyqxmd.com/read/29435975/quantifying-magnitude-of-group-level-differences-in-patient-experiences-with-health-care
#16
Denise D Quigley, Marc N Elliott, Claude Messan Setodji, Ron D Hays
OBJECTIVE: Review approaches assessing magnitude of differences in patient experience scores between different providers. DATA SOURCES: 1990-2016 literature. STUDY DESIGN: Systematic literature review. DATA EXTRACTION METHODS: Of 812 articles mentioning "CAHPS," "patient experience," "patient satisfaction," "important(ce)," "difference," or "significance," we identified 79 possible articles, yielding 35 for data abstraction...
February 12, 2018: Health Services Research
https://www.readbyqxmd.com/read/29435796/retinal-single-layer-analysis-with-optical-coherence-tomography-shows-inner-retinal-layer-thinning-in-huntington-s-disease-as-a-potential-biomarker
#17
Duygu Gulmez Sevim, Metin Unlu, Murat Gultekin, Cagatay Karaca
PURPOSE: There have been ongoing clinical trials of therapeutic agents in Huntington's disease (HD) which requires development of reliable biomarkers of disease progression. There have been studies in the literature with conflicting results on the involvement of retina in HD, and up to date there is not a study evaluating the single retinal layers in HD. We aimed to evaluate the specific retinal changes in HD and their usability as potential disease progression markers. METHODS: This cross-sectional study used spectral-domain optical coherence tomography with automatic segmentation to measure peripapillary retinal nerve fiber layer (pRNFL) thickness and the thickness and volume of retinal layers in foveal scans of 15 patients with HD and 15 age- and sex-matched controls...
February 12, 2018: International Ophthalmology
https://www.readbyqxmd.com/read/29435754/eaes-classification-of-intraoperative-adverse-events-in-laparoscopic-surgery
#18
N K Francis, N J Curtis, J A Conti, J D Foster, H J Bonjer, G B Hanna
BACKGROUND: Surgical outcomes are traditionally evaluated by post-operative data such as histopathology and morbidity. Although these outcomes are reported using accepted systems, their ability to influence operative performance is limited by their retrospective application. Interest in direct measurement of intraoperative events is growing but no available systems applicable to routine practice exist. We aimed to develop a structured, practical method to report intraoperative adverse events enacted during minimal access surgical procedures...
February 12, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29435744/design-and-implementation-of-an-electromagnetic-ultrasound-based-navigation-technique-for-laparoscopic-ablation-of-liver-tumors
#19
Iwan Paolucci, Marius Schwalbe, Gian Andrea Prevost, Anja Lachenmayer, Daniel Candinas, Stefan Weber, Pascale Tinguely
BACKGROUND: Efficient laparoscopic ablation of liver tumors relies on precise tumor visualization and accurate positioning of ablation probes. This study evaluates positional accuracy and procedural efficiency of a dynamic navigation technique based on electromagnetic-tracked laparoscopic ultrasound (ELUS) for laparoscopic ablation of liver tumors. METHODS: The proposed navigation approach combines intraoperative 2D ELUS-based planning for navigated positioning of ablation probes, with immediate 3D ELUS-based validation of intrahepatic probe position...
February 12, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29435182/dual-trigger-of-triptorelin-and-hcg-optimizes-clinical-outcome-for-high-ovarian-responder-in-gnrh-antagonist-protocols
#20
Saijiao Li, Danni Zhou, Tailang Yin, Wangming Xu, Qingzhen Xie, Dan Cheng, Jing Yang
In this paper, a retrospective cohort study was conducted to the high ovarian responders in GnRH-antagonist protocols of IVF/ICSI cycles. The purpose of the study is to investigate whether dual triggering of final oocyte maturation with a combination of gonadotropin-releasing hormone (GnRH) agonist and human chorionic gonadotropin (HCG) can improve the clinical outcome compared with traditional dose (10000IU) HCG trigger and low-dose (8000IU) HCG trigger for high ovarian responders in GnRH-antagonist in vitro fertilization/intracytoplasmic sperm injection (IVF-ICSI) cycles...
January 12, 2018: Oncotarget
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