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https://www.readbyqxmd.com/read/27896970/empowering-multi-cohort-gene-expression-analysis-to-increase-reproducibility
#1
Winston A Haynes, Francesco Vallania, Charles Liu, Erika Bongen, Aurelie Tomczak, Marta Andres-Terrè, Shane Lofgren, Andrew Tam, Cole A Deisseroth, Matthew D Li, Timothy E Sweeney, Purvesh Khatri
A major contributor to the scientific reproducibility crisis has been that the results from homogeneous, single-center studies do not generalize to heterogeneous, real world populations. Multi-cohort gene expression analysis has helped to increase reproducibility by aggregating data from diverse populations into a single analysis. To make the multi-cohort analysis process more feasible, we have assembled an analysis pipeline which implements rigorously studied meta-analysis best practices. We have compiled and made publicly available the results of our own multi-cohort gene expression analysis of 103 diseases, spanning 615 studies and 36,915 samples, through a novel and interactive web application...
2016: Pacific Symposium on Biocomputing
https://www.readbyqxmd.com/read/27893043/appropriate-use-of-high-sensitivity-cardiac-troponin-levels-in-patients-with-suspected-acute-myocardial-infarction
#2
Kasper Glerup Lauridsen, Jesper Revsholm, Bo Løfgren
No abstract text is available yet for this article.
November 23, 2016: JAMA Cardiology
https://www.readbyqxmd.com/read/27834115/long-term-functional-outcomes-after-radical-cystectomy-with-ileal-bladder-substitute-does-the-definition-of-continence-matter
#3
Fredrik Liedberg, Göran Ahlgren, Gediminas Baseckas, Sigurdur Gudjonsson, Ulf Håkansson, Sara Lindquist, Annica Löfgren, Oliver Patschan, Carina Siller, Gottfrid Sjödahl
OBJECTIVE: Functional outcomes after ileal bladder substitution reflect the expectations of future patients at a particular centre. The aim of this study was to use validated questionnaires and a pad-weighing test to investigate functional outcomes after neobladder reconstruction at long-term follow-up in patients at a single centre. MATERIALS AND METHODS: During 2005 - 2015, 75 patients received a Studer ileal bladder substitute at the Department of Urology, Malmö...
November 11, 2016: Scandinavian Journal of Urology
https://www.readbyqxmd.com/read/27797838/systemic-sarcoidosis-first-manifesting-in-a-tattoo-in-the-setting-of-immune-checkpoint-inhibition
#4
Charissa Kim, Jianjun Gao, Vickie R Shannon, Arlene Siefker-Radtke
The use of immune checkpoint inhibitors is revolutionising the treatment of cancer. However, their unique toxicity profile is substantially different from what has been observed with traditional chemotherapy, resulting in a novel learning curve for medical oncologists. Early recognition of these toxicities can make a substantial impact in ameliorating these side effects in the oncological and medical-surgical fields. Here, we present a case of Lofgren syndrome sarcoidosis, which first manifested in a tattoo in a patient with metastatic urothelial cancer on therapy with anti-CTLA-4 (ipilimumab) and anti-PD1 (nivolumab)...
October 26, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27780267/postpartum-hemorrhage-in-women-with-von-willebrand-disease-a-retrospective-observational-study
#5
Igor Govorov, Signe Löfgren, Roza Chaireti, Margareta Holmström, Katarina Bremme, Miriam Mints
INTRODUCTION: von Willebrand disease (VWD) is a hereditary bleeding disorder, caused by a deficiency in the levels and/or function of von Willebrand factor (VWF). Women with VWD appear to be at increased risk of experiencing postpartum hemorrhage (PPH), though the levels of VWF increase during pregnancy. There is limited knowledge of how PPH is associated with the subtype of VWD, plasma levels of other coagulations factors than VWF and given hemostatic treatment. AIMS: The aims were to investigate the incidence of PPH in women with VWD and to analyse the correlation between PPH and: (1) type of VWD, (2) laboratory monitoring of VWF and FVIII and (3) hemostatic drug treatment...
2016: PloS One
https://www.readbyqxmd.com/read/27760571/patients-as-patches-ecology-and-epidemiology-in-healthcare-environments
#6
Eric T Lofgren, Andrea M Egizi, Nina H Fefferman
The modern healthcare system involves complex interactions among microbes, patients, providers, and the built environment. It represents a unique and challenging setting for control of the emergence and spread of infectious diseases. We examine an extension of the perspectives and methods from ecology (and especially urban ecology) to address these unique issues, and we outline 3 examples: (1) viewing patients as individual microbial ecosystems; (2) the altered ecology of infectious diseases specifically within hospitals; and (3) ecosystem management perspectives for infection surveillance and control...
December 2016: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/27732712/hernia-mesh-repair-and-global-surgery
#7
Jessica Beard, Michael Ohene-Yeboah, Jenny Löfgren
No abstract text is available yet for this article.
October 12, 2016: JAMA Surgery
https://www.readbyqxmd.com/read/27709604/annual-research-review-quality-of-life-and-childhood-mental-and-behavioural-disorders-a-critical-review-of-the-research
#8
Ulf Jonsson, Iman Alaie, Anna Löfgren Wilteus, Eric Zander, Peter B Marschik, David Coghill, Sven Bölte
BACKGROUND: An individual's subjective perception of well-being is increasingly recognized as an essential complement to clinical symptomatology and functional impairment in children's mental health. Measurement of quality of life (QoL) has the potential to give due weight to the child's perspective. SCOPE AND METHODOLOGY: Our aim was to critically review the current evidence on how childhood mental disorders affect QoL. First, the major challenges in this research field are outlined...
October 6, 2016: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/27681518/estrogen-receptor-alpha-gene-esr1-polymorphism-can-contribute-to-clinical-findings-in-systemic-lupus-erythematosus-patients
#9
M N Drehmer, D Andrade, I A Pereira, A R Marrero, Y C N Muniz, I R de Souza, S E Löfgren
BACKGROUND: Estrogens have a modulatory effect on several immune responses, many of which are correlated to autoimmune diseases. Estrogens act through binding to their receptors, and an overexpression of these receptors has been identified in patients with different autoimmune diseases. Here we analyzed the association of a putative functional genetic variant in the main estrogen receptor (ERα) gene (ESR1), and the susceptibility to clinical findings and severity of SLE. METHODS: A total of 426 individuals (266 healthy controls and 160 SLE patients) were genotyped for the polymorphism rs2234693 in the ESR1 gene...
September 27, 2016: Lupus
https://www.readbyqxmd.com/read/27681513/advanced-practice-providers-perceptions-of-patient-workload-results-of-a-multi-institutional-survey
#10
April N Kapu, Carmel A McComiskey, Lacey Buckler, Jennifer Derkazarian, Tammy Goda, Maria A Lofgren, Colleen K McIlvennan, Julie Raaum, Patricia M Selig, Corinna Sicoutris, Barbara Todd, Vicki Turner, Elizabeth Card, Nancy Wells
OBJECTIVE: This study examines data collected from a survey of advanced practice providers' (APPs') perceptions of reasonable versus actual APP-to-patient ratios and other factors that affect workload burden in both inpatient and outpatient clinical settings. BACKGROUND: Advanced practice providers provide accessible, cost-effective, and quality care in a growing number of specialty practices across multiple patient care settings. They are caring for higher volumes of patients and assuming more responsibilities while continuing to navigate highly complex healthcare systems...
October 2016: Journal of Nursing Administration
https://www.readbyqxmd.com/read/27674580/patient-experience-survey-of-early-stage-breast-cancer-patients-undergoing-whole-breast-radiation-therapy
#11
G Lee, R Dinniwell, T W Fyles, T D Conrad, K Han, W Levin, F F Liu, S Lofgren, A Koch-Fitsialos, G Devins, N Emad, B Pitcher, T Panzarella, A Koch
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27671710/unlocking-the-black-box-teaching-mathematical-modeling-with-popular-culture
#12
Eric T Lofgren
Mathematical modeling is an important tool in biological research, allowing for the synthesis of results from many studies into an understanding of a system. Despite this, the need for extensive subject matter knowledge and complex mathematics often leaves modeling as an esoteric subspecialty. A 2-fold approach can be used to make modeling more approachable for students and those interested in obtaining a functional knowledge of modeling. The first is the use of a popular culture disease system-a zombie epidemic-to allow for exploration of the concepts of modeling using a flexible framework...
October 2016: FEMS Microbiology Letters
https://www.readbyqxmd.com/read/27658651/a-novel-protocol-for-dispatcher-assisted-cpr-improves-cpr-quality-and-motivation-among-rescuers-a-randomized-controlled-simulation-study
#13
Stinne Eika Rasmussen, Mette Amalie Nebsbjerg, Lise Qvirin Krogh, Katrine Bjørnshave, Kristian Krogh, Jonas Agerlund Povlsen, Ingunn Skogstad Riddervold, Thorbjørn Grøfte, Hans Kirkegaard, Bo Løfgren
BACKGROUND: Emergency dispatchers use protocols to instruct bystanders in cardiopulmonary resuscitation (CPR). Studies changing one element in the dispatcher's protocol report improved CPR quality. Whether several changes interact is unknown and the effect of combining multiple changes previously reported to improve CPR quality into one protocol remains to be investigated. We hypothesize that a novel dispatch protocol, combining multiple beneficial elements improves CPR quality compared with a standard protocol...
September 19, 2016: Resuscitation
https://www.readbyqxmd.com/read/27649279/norovirus-dynamics-in-wastewater-discharges-and-in-the-recipient-drinking-water-source-long-term-monitoring-and-hydrodynamic-modeling
#14
Olaf Dienus, Ekaterina Sokolova, Fredrik Nyström, Andreas Matussek, Sture Löfgren, Lena Blom, Thomas J R Pettersson, Per-Eric Lindgren
Norovirus (NoV) that enters drinking water sources with wastewater discharges is a common cause of waterborne outbreaks. The impact of wastewater treatment plants (WWTPs) on the river Göta älv (Sweden) was studied using monitoring and hydrodynamic modeling. The concentrations of NoV genogroups (GG) I and II in samples collected at WWTPs and drinking water intakes (source water) during one year were quantified using duplex real-time reverse-transcription polymerase chain reaction. The mean (standard deviation) NoV GGI and GGII genome concentrations were 6...
October 4, 2016: Environmental Science & Technology
https://www.readbyqxmd.com/read/27608662/risks-of-death-and-severe-disease-in-patients-with-middle-east-respiratory-syndrome-coronavirus-2012-2015
#15
Caitlin M Rivers, Maimuna S Majumder, Eric T Lofgren
Middle East respiratory syndrome coronavirus (MERS-CoV) is an emerging pathogen, first recognized in 2012, with a high case fatality risk, no vaccine, and no treatment beyond supportive care. We estimated the relative risks of death and severe disease among MERS-CoV patients in the Middle East between 2012 and 2015 for several risk factors, using Poisson regression with robust variance and a bootstrap-based expectation maximization algorithm to handle extensive missing data. Increased age and underlying comorbidity were risk factors for both death and severe disease, while cases arising in Saudi Arabia were more likely to be severe...
September 15, 2016: American Journal of Epidemiology
https://www.readbyqxmd.com/read/27583087/amylo%C3%A3-dosis-sarcoidosis-and-systemic-lupus-erythematosus
#16
Amel Rezgui, Imene Ben Hassine, Monia Karmani, Fatma Ben Fredj, Chadia Laouani
The occurrence of renal and multiple organ Amyloïdosis is currently considered exceptional in the course of systemic lupus erythematosus. We report a case of a concomitant SLE and Amyloïdosis in a 57 year old female patient with hypothyroidism history, who presented with erythema nodosum, fever, arthralgia and sicca syndrome. Biological findings showed an inflammatory syndrome, renal failure, proteinuria (1g / 24h), positive auto antibodies and anti DNA. Lung radiology revealed medistinal lymphadenopathy, pleural nodules, ground glass infiltrates and pleuritis...
2016: Pan African Medical Journal
https://www.readbyqxmd.com/read/27564856/a-5-to-8-year-randomized-study-on-the-treatment-of-cervical-radiculopathy-anterior-cervical-decompression-and-fusion-plus-physiotherapy-versus-physiotherapy-alone
#17
Markus Engquist, Håkan Löfgren, Birgitta Öberg, Anders Holtz, Anneli Peolsson, Anne Söderlund, Ludek Vavruch, Bengt Lind
OBJECTIVE The aim of this study was to evaluate the 5- to 8-year outcome of anterior cervical decompression and fusion (ACDF) combined with a structured physiotherapy program as compared with that following the same physiotherapy program alone in patients with cervical radiculopathy. No previous prospective randomized studies with a follow-up of more than 2 years have compared outcomes of surgical versus nonsurgical intervention for cervical radiculopathy. METHODS Fifty-nine patients were randomized to ACDF surgery with postoperative physiotherapy (30 patients) or to structured physiotherapy alone (29 patients)...
August 26, 2016: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/27560554/fast-track-access-to-urologic-care-for-patients-with-macroscopic-haematuria-is-efficient-and-cost-effective-results-from-a-prospective-intervention-study
#18
Fredrik Liedberg, Ulf Gerdtham, Katarina Gralén, Sigurdur Gudjonsson, Staffan Jahnson, Irene Johansson, Oskar Hagberg, Staffan Larsson, Anna-Karin Lind, Annica Löfgren, Jenny Wanegård, Hanna Åberg, Mef Nilbert
BACKGROUND: The delay between onset of macroscopic haematuria and diagnosis of bladder cancer is often long. METHODS: We evaluated timely diagnosis and health-care costs for patients with macroscopic haematuria given fast-track access to diagnostics. During a 15-month period, a telephone hotline for fast-track diagnostics was provided in nine Swedish municipalities for patients aged ⩾50 years with macroscopic haematuria. The control group comprised 101 patients diagnosed with bladder cancer in the same catchment area with macroscopic haematuria who underwent regular diagnostic process...
September 27, 2016: British Journal of Cancer
https://www.readbyqxmd.com/read/27515443/screening-method-for-m-proteins-in-serum-using-nanobody-enrichment-coupled-to-maldi-tof-mass-spectrometry
#19
Mindy C Kohlhagen, David R Barnidge, John R Mills, Joshua Stoner, Kari M Gurtner, Andrea M Liptac, Denise I Lofgren, Patrick M Vanderboom, Angela Dispenzieri, Jerry A Katzmann, Maria A V Willrich, Melissa R Snyder, David L Murray
BACKGROUND: Current recommendations for screening for monoclonal gammopathies include serum protein electrophoresis (PEL), imunofixation electrophoresis (IFE), and free light chain (FLC) ratios to identify or rule out an M-protein. The aim of this study was to examine the feasibility of an assay based on immunoenrichment and MALDI-TOF-MS (MASS-SCREEN) to qualitatively screen for M-proteins. METHODS: Serum from 556 patients previously screened for M-proteins by PEL and IFE were immunopurified using a κ/λ-specific nanobody bead mixture...
October 2016: Clinical Chemistry
https://www.readbyqxmd.com/read/27473164/resistance-exercise-improves-physical-fatigue-in-women-with-fibromyalgia-a-randomized-controlled-trial
#20
Anna Ericsson, Annie Palstam, Anette Larsson, Monika Löfgren, Indre Bileviciute-Ljungar, Jan Bjersing, Björn Gerdle, Eva Kosek, Kaisa Mannerkorpi
BACKGROUND: Fibromyalgia (FM) affects approximately 1-3 % of the general population. Fatigue limits the work ability and social life of patients with FM. A few studies of physical exercise have included measures of fatigue in FM, indicating that exercise can decrease fatigue levels. There is limited knowledge about the effects of resistance exercise on multiple dimensions of fatigue in FM. The present study is a sub-study of a multicenter randomized controlled trial in women with FM...
2016: Arthritis Research & Therapy
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