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https://www.readbyqxmd.com/read/28628281/genomic-analysis-of-melanoma-evolution-following-a-30-year-disease-free-interval
#1
Jerry J Miller, Kristopher A Lofgren, Sarah R Hughes, Steven E Cash, Paraic A Kenny
Ultra-late melanoma recurrence is infrequent, poorly understood and, in most cases, difficult to unambiguously distinguish from a new primary melanoma. We identified a patient with a second melanoma diagnosed after a 30 year disease-free interval, and sought to determine if this new lesion was a recurrence of the original melanoma. Here we report the genomic sequence analysis of the exomes of two melanoma lesions isolated from the same individual in 1985 and 2015, and their comparison to each other and to the germline DNA of the patient...
June 19, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28627125/the-role-of-long-term-physical-exercise-on-performance-and-brain-activation-during-the-stroop-colour-word-task-in-fibromyalgia-patients
#2
S Martinsen, P Flodin, J Berrebi, M Löfgren, I Bileviciute-Ljungar, K Mannerkorpi, M Ingvar, P Fransson, E Kosek
The Stroop colour word test (SCWT) has been widely used to assess changes in cognitive performance such as processing speed, selective attention and the degree of automaticity. Moreover, the SCWT has proven to be a valuable tool to assess neuronal plasticity that is coupled to improvement in performance in clinical populations. In a previous study, we showed impaired cognitive processing during SCWT along with reduced task-related activations in patients with fibromyalgia. In this study, we used SCWT and functional magnetic resonance imagingFMRI to investigate the effects of a 15-week physical exercise intervention on cognitive performance, task-related cortical activation and distraction-induced analgesia (DIA) in patients with fibromyalgia and healthy controls...
June 18, 2017: Clinical Physiology and Functional Imaging
https://www.readbyqxmd.com/read/28625882/analysis-of-sarcoidosis-in-the-oporto-region-portugal
#3
A V Cardoso, P C Mota, N Melo, S Guimarães, C Souto Moura, J M Jesus, R Cunha, A Morais
BACKGROUND: Sarcoidosis is a systemic granulomatous disease of unknown etiology. Epidemiological studies of different populations are essential because clinical presentation, organ involvement, disease severity, and prognosis vary significantly according to region and population. The aim of this study was to assess epidemiological and clinical characteristics, staging factors, and clinical course in patients with sarcoidosis from a tertiary hospital in Oporto, Portugal. METHODS: A retrospective analysis of patients with sarcoidosis and at least 2 years of follow-up evaluated at the Centro Hospitalar de São João between 2000 and 2014...
June 15, 2017: Revista Portuguesa de Pneumologia
https://www.readbyqxmd.com/read/28621258/evaluation-of-pain-assessment-techniques-and-analgesia-efficacy-in-a-female-guinea-pig-cavia-porcellus-model-of-surgical-pain
#4
Vanessa L Oliver, Stephanie Athavale, Katherine E Simon, Lon V Kendall, Jean A Nemzek, Jennifer L Lofgren
Guinea pigs (Cavia porcellus) are a frequently used species in research, often involving potentially painful procedures.Therefore, evidence-based recommendations regarding analgesia are critically needed to optimize their wellbeing. Ourlaboratory examined the efficacy of carprofen and extended-release (ER) buprenorphine, alone and as a multimodal combination,for relieving postsurgical pain in guinea pigs. Animals were assessed by using evoked (mechanical hypersensitivity),nonevoked (video ethogram, cageside ethogram, time-to-consumption test), and clinical (weight loss) measurements for 96 h during baseline, anesthesia-analgesia, and hysterectomy conditions...
June 15, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/28577172/impact-of-surgeon-experience-on-routine-prolapse-operations
#5
Emil Nüssler, Jacob Kjær Eskildsen, Emil Karl Nüssler, Marie Bixo, Mats Löfgren
INTRODUCTION AND HYPOTHESIS: Surgical work encompasses important aspects of personal and manual skills. In major surgery, there is a positive correlation between surgical experience and results. For pelvic organ prolapse (POP), this relationship has to our knowledge never been examined. In any clinical practice, there is always a certain proportion of inexperienced surgeons. In Sweden, most prolapse surgeons have little experience in performing prolapse operations, 74% conducting the procedure once a month or less...
June 2, 2017: International Urogynecology Journal
https://www.readbyqxmd.com/read/28555810/reduced-right-ventricular-diameter-during-cardiac-arrest-caused-by-tension-pneumothorax-a-porcine-ultrasound-study
#6
P Caap, R Aagaard, E Sloth, B Løfgren, A Granfeldt
INTRODUCTION: Advanced life support (ALS) guidelines recommend ultrasound to identify reversible causes of cardiac arrest. Right ventricular (RV) dilatation during cardiac arrest is commonly interpreted as a sign of pulmonary embolism. The RV is thus a focus of clinical ultrasound examination. Importantly, in animal studies ventricular fibrillation and hypoxia results in RV dilatation. Tension pneumothorax (tPTX) is another reversible cause of cardiac arrest, however, the impact on RV diameter remains unknown...
May 28, 2017: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/28495026/neck-related-physical-function-self-efficacy-and-coping-strategies-in-patients-with-cervical-radiculopathy-a-randomized-clinical-trial-of-postoperative-physiotherapy
#7
Johanna Wibault, Birgitta Öberg, Åsa Dedering, Håkan Löfgren, Peter Zsigmond, Liselott Persson, Maria Andell, Margareta R Jonsson, Anneli Peolsson
OBJECTIVE: The purpose of this study was to compare postoperative rehabilitation with structured physiotherapy to the standard approach in patients with cervical radiculopathy (CR) in a prospective randomized study at 6 months follow-up based on measures of neck-related physical function, self-efficacy, and coping strategies. METHODS: Patients with persistent CR and scheduled for surgery (N = 202) were randomly assigned to structured postoperative physiotherapy or a standard postoperative approach...
May 9, 2017: Journal of Manipulative and Physiological Therapeutics
https://www.readbyqxmd.com/read/28488045/-musculoskeletal-manifestations-of-sarcoidosis
#8
REVIEW
P Korsten, G Chehab
Musculoskeletal manifestations in the context of sarcoidosis are frequently observed. The rheumatologist regularly encounters this disease in clinical practice. In the present review, we aim to give a current overview of the manifestations and treatments relevant to the practicing rheumatologist. The most frequently encountered manifestation is Lofgren's syndrome, which is characterized by bilateral ankle periarthritis, bilateral hilar lymphadenopathy, and erythema nodosum and has an excellent prognosis. Chronic arthropathy most commonly manifests as oligoarthritis, which sometimes hampers its differentiation from spondylarthropathies, especially when sacroiliitis, enthesitis or dactylitis are simultaneously present...
June 2017: Zeitschrift Für Rheumatologie
https://www.readbyqxmd.com/read/28476585/cd4-cd8-ratio-1-is-associated-with-lymphocyte-subsets-cmv-and-gender-in-71-year-old-individuals-5-year-follow-up-of-the-swedish-hexa-immune-longitudinal-study
#9
Jan Strindhall, Sture Löfgren, Caroline Främsth, Andreas Matussek, Malin Bengner, Jan Ernerudh, Anders Wikby
No abstract text is available yet for this article.
September 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28469621/snp-variants-in-major-histocompatibility-complex-are-associated-with-sarcoidosis-susceptibility-a-joint-analysis-in-four-european-populations
#10
Annika Wolin, Elisa Laura Lahtela, Verneri Anttila, Martin Petrek, Johan Grunewald, Coline H M van Moorsel, Anders Eklund, Jan C Grutters, Vitezslav Kolek, Frantisek Mrazek, Amit Kishore, Leonid Padyukov, Anne Pietinalho, Marcus Ronninger, Mikko Seppänen, Olof Selroos, Marja-Liisa Lokki
Sarcoidosis is a multiorgan inflammatory disorder with heritability estimates up to 66%. Previous studies have shown the major histocompatibility complex (MHC) region to be associated with sarcoidosis, suggesting a functional role for antigen-presenting molecules and immune mediators in the disease pathogenesis. To detect variants predisposing to sarcoidosis and to identify genetic differences between patient subgroups, we studied four genes in the MHC Class III region (LTA, TNF, AGER, BTNL2) and HLA-DRA with tag-SNPs and their relation to HLA-DRB1 alleles...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28452827/re-integrating-complex-systems-thinking-into-epidemiologic-research
#11
Eric T Lofgren, Brandon D Marshall, Sandro Galea
No abstract text is available yet for this article.
April 27, 2017: Epidemiology
https://www.readbyqxmd.com/read/28449960/evaluating-the-change-in-axial-vertebral-rotation-following-thoracoscopic-anterior-scoliosis-surgery-using-low-dose-computed-tomography
#12
J Paige Little, Maree T Izatt, Clayton J Adam, Olivia Lofgren, Anna Sundberg, Robert D Labrom, Geoffrey N Askin
BACKGROUND CONTEXT: In recent years, there has been increasing appreciation of the need to treat scoliosis as a three-dimensional deformity. PURPOSE: Assessment of surgical strategies and outcomes should consider not only the coronal plane correction but also derotation of the transverse plane deformity that can affect trunk appearance. STUDY DESIGN: This study included a cohort of 29 female adolescent idiopathic scoliosis patients who received thoracoscopic single rod anterior fusion (TASF) surgery...
May 2017: Spine Deformity
https://www.readbyqxmd.com/read/28444984/abdominal-adhesions-in-gynaecologic-surgery-after-caesarean-section-a-longitudinal-population-based-register-study
#13
Susanne Hesselman, Ulf Högberg, Eva-Britta Råssjö, Erica Schytt, Mats Löfgren, Maria Jonsson
OBJECTIVE: The aim of the study was to evaluate the association between abdominal adhesions at time of gynaecologic surgery and a history of caesarean delivery, and to investigate obstetric factors contributing to adhesion formation after caesarean section (CS). DESIGN: Longitudinal population based register study. SETTING: Sweden. POPULATION: Women undergoing benign hysterectomy and/or adnexal surgery in Sweden, 2000-2014, with a previous delivery during 1973-2013 (N=15,479)...
April 26, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28430698/the-right-ventricle-is-dilated-during-resuscitation-from-cardiac-arrest-caused-by-hypovolemia-a-porcine-ultrasound-study
#14
Rasmus Aagaard, Asger Granfeldt, Morten T Bøtker, Troels Mygind-Klausen, Hans Kirkegaard, Bo Løfgren
OBJECTIVES: Dilation of the right ventricle during cardiac arrest and resuscitation may be inherent to cardiac arrest rather than being associated with certain causes of arrest such as pulmonary embolism. This study aimed to compare right ventricle diameter during resuscitation from cardiac arrest caused by hypovolemia, hyperkalemia, or primary arrhythmia (i.e., ventricular fibrillation). DESIGN: Thirty pigs were anesthetized and then randomized to cardiac arrest induced by three diffrent methods...
April 20, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28421309/genetic-makeup-of-shiga-toxin-producing-escherichia-coli-in-relation-to-clinical-symptoms-and-duration-of-shedding-a-microarray-analysis-of-isolates-from-swedish-children
#15
A Matussek, C Jernberg, I-M Einemo, S Monecke, R Ehricht, I Engelmann, S Löfgren, S Mernelius
Shiga toxin (Stx)-producing Escherichia coli (STECs) cause non-bloody diarrhea, hemorrhagic colitis, and hemolytic uremic syndrome, and are the primary cause of acute renal failure in children worldwide. This study investigated the correlation of genetic makeup of STEC strains as revealed by DNA microarray to clinical symptoms and the duration of STEC shedding. All STEC isolated (n = 96) from patients <10 years of age in Jönköping County, Sweden from 2003 to 2015 were included. Isolates were characterized by DNA microarray, including almost 280 genes...
April 19, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28403120/detection-of-pulmonary-embolism-during-cardiac-arrest-ultrasonographic-findings-should-be-interpreted-with-caution
#16
Rasmus Aagaard, Philip Caap, Nicolaj C Hansson, Morten T Bøtker, Asger Granfeldt, Bo Løfgren
OBJECTIVES: The aim of this study was to test the hypothesis that the right ventricle is more dilated during resuscitation from cardiac arrest caused by pulmonary embolism, compared with hypoxia and primary arrhythmia. DESIGN: Twenty-four pigs were anesthetized and cardiac arrest was induced using three different methods. Pigs were resuscitated after 7 minutes of untreated cardiac arrest. Ultrasonographic images were obtained and the right ventricular diameter was measured...
July 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28396505/genetic-characterisation-of-dog-personality-traits
#17
Joanna Ilska, Marie J Haskell, Sarah C Blott, Enrique Sánchez-Molano, Zita Polgar, Sarah E Lofgren, Dylan N Clements, Pam Wiener
The genetic architecture of behavioural traits in dogs is of great interest to owners, breeders and professionals involved in animal welfare, as well as to scientists studying the genetics of animal (including human) behaviour. The genetic component of dog behaviour is supported by between-breed differences and some evidence of within-breed variation. However, it is a challenge to gather sufficiently large datasets to dissect the genetic basis of complex traits such as behaviour, which are both time-consuming and logistically difficult to measure, and known to be influenced by non-genetic factors...
April 10, 2017: Genetics
https://www.readbyqxmd.com/read/28387077/-erythema-nodosum-a-panniculitis-of-diverse-origins
#18
REVIEW
G E Piérard, C Piérard-Franchimont
Erythema nodosum is an acute nodular panniculitis, mainly affecting young women. Diverse etiologies are evoked, but the most frequent are sarcoidosis (Löfgren syndrome), streptococcal infections, yersiniosis and inflammatory enteropathies. Antalgic drugs and rest are usually adequate in this condition, which is spontaneously of favourable evolution. Treatment of the cause is open to discussion, considering their lack of effect on the evolution of erythema nodosum.
January 2017: Revue Médicale de Liège
https://www.readbyqxmd.com/read/28373104/nanocrystal-formulations-of-a-poorly-soluble-drug-2-evaluation-of-nanocrystal-liver-uptake-and-distribution-after-intravenous-administration-to-mice
#19
Kalle Sigfridsson, Pia Skantze, Urban Skantze, Lena Svensson, Lars Löfgren, Pär Nordell, Erik Michaëlsson, Bård Smedsrød, Britt Fuglesteg, Kjetil Elvevold, Lennart Lindfors
A stabilized high drug load intravenous formulation could allow compounds with less optimal pharmacokinetic profiles to be developed. Polyethylene glycol (PEG)-ylation is a frequently used strategy for particle delivery systems to avoid the liver, thereby extending blood circulation time. The present work reports the mouse in vivo distribution after i.v. administration of a series of nanocrystals prepared with the bead milling technique and PEG-ylated with DSPE-PEG2000 and Pluronic F127, with and without polyvinylpyrrolidone K30 (PVP)/Aerosol OT (AOT) as primary stabilizers...
March 31, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28345241/the-new-swedish-report-on-shaken-baby-syndrome-is-misleading
#20
Kerstin Hellgren, Ann Hellström, Anna-Lena Hård, Lena Jacobson, Ulrika Lidén, Stefan Löfgren, Kristina Teär Fahnehjelm, Jan Ygge
No abstract text is available yet for this article.
March 27, 2017: Acta Paediatrica
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