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https://www.readbyqxmd.com/read/28214538/contemporary-animal-models-of-cardiac-arrest-a-systematic-review
#1
REVIEW
Mikael Vognsen, Bjørn K Fabian-Jessing, Niels Secher, Bo Løfgren, Cameron Dezfulian, Lars W Andersen, Asger Granfeldt
AIM OF THE STUDY: Animal models are widely used in cardiac arrest research. This systematic review aimed to provide an overview of contemporary animal models of cardiac arrest. METHODS: Using a comprehensive research strategy, we searched PubMed and EMBASE from March 8, 2011 to March 8, 2016 for cardiac arrest animal models. Two investigators reviewed titles and abstracts for full text inclusions from which data were extracted according to pre-defined definitions...
February 15, 2017: Resuscitation
https://www.readbyqxmd.com/read/28212248/use-of-echocardiography-in-critical-illness-dead-or-alive-does-it-matter
#2
Rasmus Aagaard, Asger Granfledt, Morten Thingemann Bødtker, Bo Løfgren
No abstract text is available yet for this article.
March 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28206682/cost-effectiveness-of-groin-hernia-repair-from-a-randomized-clinical-trial-comparing-commercial-versus-low-cost-mesh-in-a-low-income-country
#3
J Löfgren, A Matovu, A Wladis, C Ibingira, P Nordin, E Galiwango, B C Forsberg
BACKGROUND: Over 200 million people worldwide live with groin hernia and 20 million are operated on each year. In resource-scarce settings, the superior surgical technique using a synthetic mesh is not affordable. A low-cost alternative is needed. The objective of this study was to calculate and compare costs and cost-effectiveness of inguinal hernia mesh repair using a low-cost versus a commercial mesh in a rural setting in Uganda. METHODS: This is a cost-effectiveness analysis of a double-blinded RCT comparing outcomes from groin hernia mesh repair using a low-cost mesh and a commercially available mesh...
February 16, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/28203697/pandemic
#4
Eric T Lofgren, Kristen M Rapazzo
No abstract text is available yet for this article.
February 15, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28182756/correction-postpartum-hemorrhage-in-women-with-von-willebrand-disease-a-retrospective-observational-study
#5
Igor Govorov, Signe Löfgren, Roza Chaireti, Margareta Holmström, Katarina Bremme, Miriam Mints
[This corrects the article DOI: 10.1371/journal.pone.0164683.].
2017: PloS One
https://www.readbyqxmd.com/read/28159576/humoral-immune-profiling-of-mycobacterial-antigen-recognition-in-sarcoidosis-and-l%C3%A3-fgren-s-syndrome-using-high-content-peptide-microarrays
#6
REVIEW
Giovanni Ferrara, Davide Valentini, Martin Rao, Jan Wahlström, Johan Grunewald, Lars-Olof Larsson, Susanna Brighenti, Ernest Dodoo, Alimuddin Zumla, Markus Maeurer
INTRODUCTION: Sarcoidosis is considered an idiopathic granulomatous disease, although similar immunological and clinical features with tuberculosis (TB) suggest mycobacterial involvement in its pathogenesis. High-content peptide microarrays (HCPM) may help to decipher mycobacteria-specific antibody reactivity in sarcoidosis. METHODS: Serum samples from patients with sarcoidosis, Löfgren's syndrome, and TB, as well as from healthy individuals (12/group), were tested on HCPM containing 5964 individual peptides spanning 154 Mycobacterium tuberculosis proteins displayed as 15-amino acid stretches...
January 31, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28155057/omentectomy-in-addition-to-bariatric-surgery-a-5-year-follow-up
#7
Daniel P Andersson, Daniel Eriksson-Hogling, Jesper Bäckdahl, Anders Thorell, Patrik Löfgren, Mikael Rydén, Peter Arner, Johan Hoffstedt
AIM: Omentectomy in addition to bariatric surgery has been suggested to improve metabolic outcome but short-term (6-24 months) studies have refuted this notion. We investigated whether there was any long-term impact of omentectomy. METHODS: Forty-nine obese women underwent gastric bypass surgery and were randomly assigned to omentectomy (n = 26) or not (n = 23). They were re-examined after 5 years including dual-energy X-ray absorptiometry for body composition, blood pressure and blood sampling...
February 2, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28143463/monitoring-training-activity-during-gait-related-balance-exercise-in-individuals-with-parkinson-s-disease-a-proof-of-concept-study
#8
David Conradsson, Håkan Nero, Niklas Löfgren, Maria Hagströmer, Erika Franzén
BACKGROUND: Despite the benefits of balance exercise in clinical populations, balance training programs tend to be poorly described, which in turn makes it difficult to evaluate important training components and compare between programs. However, the use of wearable sensors may have the potential to monitor certain elements of balance training. Therefore, this study aimed to investigate the feasibility of using wearable sensors to provide objective indicators of the levels and progression of training activity during gait-related balance exercise in individuals with Parkinson's disease...
January 31, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28129004/interprofessional-education-in-a-student-led-emergency-department-a-realist-evaluation
#9
Anne Ericson, Susanne Löfgren, Gunilla Bolinder, Scott Reeves, Simon Kitto, Italo Masiello
This article reports a realist evaluation undertaken to identify factors that facilitated or hindered the successful implementation of interprofessional clinical training for undergraduate students in an emergency department. A realist evaluation provides a framework for understanding how the context and underlying mechanisms affect the outcome patterns of an intervention. The researchers gathered both qualitative and quantitative data from internal documents, semi-structured interviews, observations, and questionnaires to study what worked, for whom, and under what circumstances in this specific interprofessional setting...
January 27, 2017: Journal of Interprofessional Care
https://www.readbyqxmd.com/read/28116468/patient-reported-lower-urinary-tract-symptoms-after-hysterectomy-or-hysteroscopy-a-study-from-the-swedish-quality-register-for-gynecological-surgery
#10
Mathias Pålsson, Jan-Henrik Stjerndahl, Gabriel Granåsen, Mats Löfgren, Karin Sundfeldt
INTRODUCTION AND HYPOTHESIS: Hysterectomy is sometimes considered the cause of lower urinary tract symptoms (LUTS). We hypothesized that hysterectomy for abnormal uterine bleeding and/or symptoms of fibroids is more likely to cause LUTS than a hysteroscopic procedure for the same indications. METHODS: Two groups of women were compared: one group comprised 3,618 women who had had a hysterectomy due to abnormal uterine bleeding or symptoms of fibroids and the other group comprised 238 women who had had hysteroscopic treatment for the same indications...
January 23, 2017: International Urogynecology Journal
https://www.readbyqxmd.com/read/28111998/recent-advances-in-aids-related-cryptococcal-meningitis-treatment-with-an-emphasis-on-resource-limited-settings
#11
Sarah Lofgren, Mahsa Abassi, Joshua Rhein, David R Boulware
Recent advances in the treatment and prevention of cryptococcal meningitis have the potential to decrease AIDS-related deaths. Areas covered. Targeted screening for asymptomatic cryptococcal antigenemia in persons with AIDS is a cost effective method for reducing early mortality in patients on antiretroviral therapy. For persons with symptomatic cryptococcal meningitis, optimal initial management with amphotericin and flucytosine improves survival compared to alternative therapies; however, amphotericin is difficult to administer and flucytosine has not been available in middle or low income countries, where cryptococcal meningitis is most prevalent...
January 23, 2017: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/28079845/predictive-value-of-c-reactive-protein-and-clinically-relevant-baseline-variables-in-sarcoidosis
#12
Melissa J McDonnell, Mohammed I Saleem, Deidre Wall, J J Gilmartin, R M Rutherford, Anthony O'Regan
BACKGROUND: This study aims to examine the predictive and prognostic implications of C-reactive protein (CRP) and clinically relevant baseline variables in determining treatment indication and disease progression in a large clinical cohort of patients with stable sarcoidosis. METHODS: A retrospective observational study of 328 sarcoidosis patients attending a regional tertiary referral centre over a 26-year period was performed. Clinical, biochemical, radiological and physiological data were analysed according to a clinically relevant dichotomous cutpoint of CRP...
December 23, 2016: Sarcoidosis, Vasculitis, and Diffuse Lung Diseases: Official Journal of WASOG
https://www.readbyqxmd.com/read/28054475/design-and-control-of-integrated-chromatography-column-sequences
#13
Niklas Andersson, Anton Löfgren, Marianne Olofsson, Anton Sellberg, Peter Tiainen, Bernt Nilsson
To increase the productivity in biopharmaceutical production a natural step is to introduce integrated continuous biomanufacturing which leads to fewer buffer and storage tanks, smaller sizes of integrated unit operations and full automation of the operation. The main contribution of this work is to illustrate a methodology for design and control of a downstream process based on integrated column sequences. For small scale production, e.g. pre-clinical studies, integrated column sequences can be implemented on a single chromatography system...
January 5, 2017: Biotechnology Progress
https://www.readbyqxmd.com/read/28052703/a-client-centred-programme-focusing-energy-conservation-for-people-with-heart-failure
#14
Eva-Britt Norberg, Britta Löfgren, Kurt Boman, Patrik Wennberg, Margareta Brännström
AIM: The purpose of this study was to describe clients and occupational therapists (OTs) experiences of a home-based programme focusing energy conservation strategies (ECS) for clients with chronic heart failure (CHF). METHODS: The programme, based on occupational therapy intervention process model (OTIPM), was led by two OTs in primary health care. Five clients' self-reported activities of daily living (ADL), fatigue, depression, goal achievements and use of ECS...
January 5, 2017: Scandinavian Journal of Occupational Therapy
https://www.readbyqxmd.com/read/28018971/integrated-multicohort-analysis-of-systemic-sclerosis-identifies-robust-transcriptional-signature-of-disease-severity
#15
Shane Lofgren, Monique Hinchcliff, Mary Carns, Tammara Wood, Kathleen Aren, Esperanza Arroyo, Peggie Cheung, Alex Kuo, Antonia Valenzuela, Anna Haemel, Paul J Wolters, Jessica Gordon, Robert Spiera, Shervin Assassi, Francesco Boin, Lorinda Chung, David Fiorentino, Paul J Utz, Michael L Whitfield, Purvesh Khatri
Systemic sclerosis (SSc) is a rare autoimmune disease with the highest case-fatality rate of all connective tissue diseases. Current efforts to determine patient response to a given treatment using the modified Rodnan skin score (mRSS) are complicated by interclinician variability, confounding, and the time required between sequential mRSS measurements to observe meaningful change. There is an unmet critical need for an objective metric of SSc disease severity. Here, we performed an integrated, multicohort analysis of SSc transcriptome data across 7 datasets from 6 centers composed of 515 samples...
December 22, 2016: JCI Insight
https://www.readbyqxmd.com/read/27997918/single-nucleotide-polymorphisms-and-cancer-risk-tumor-recurrence-or-survival-of-head-and-neck-cancer-patients
#16
Nongnit Laytragoon-Lewin, Lena Cederblad, Bengt-Åke Andersson, Mattias Olin, Mats Nilsson, Lars Erik Rutqvist, Jan Lundgren, Mats Engström, Wieslaw Tytor, Sture Löfgren, Freddi Lewin
OBJECTIVE: This paper aims at studying the influence of single-nucleotide polymorphisms (SNPs) on cancer risk, tumor recurrence, and survival in head and neck (H&N) cancer patients. METHODS: A total of 45 SNPs in 41 genes were investigated. A total of 174 Caucasian H&N cancer patients and 245 healthy blood donors were enrolled in the study. RESULTS: Ten SNPs were associated with H&N cancer risk, but the identified SNPs differed among males and females...
December 21, 2016: Oncology
https://www.readbyqxmd.com/read/27995653/influence-of-misfit-on-the-occurrence-of-veneering-porcelain-fractures-chipping-in-implant-supported-metal-ceramic-fixed-dental-prostheses-an-in%C3%A2-vitro-pilot-trial
#17
Nils Löfgren, Christel Larsson, Nikos Mattheos, Martin Janda
OBJECTIVE: Technical complications such as veneer fractures are more common in implant-supported than tooth-supported restorations. The underlying causes have not been fully identified. The aim of this study was to evaluate whether misfit between the restoration and the implant may affect the risk of veneer fractures. MATERIALS AND METHODS: Twenty standardized five-unit implant-supported metal-ceramic fixed dental prostheses (FDP)s were manufactured and fixed in acrylic blocks...
December 19, 2016: Clinical Oral Implants Research
https://www.readbyqxmd.com/read/27896970/empowering-multi-cohort-gene-expression-analysis-to-increase-reproducibility
#18
Winston A Haynes, Francesco Vallania, Charles Liu, Erika Bongen, Aurelie Tomczak, Marta Andres-Terrè, Shane Lofgren, Andrew Tam, Cole A Deisseroth, Matthew D Li, Timothy E Sweeney, Purvesh Khatri
A major contributor to the scientific reproducibility crisis has been that the results from homogeneous, single-center studies do not generalize to heterogeneous, real world populations. Multi-cohort gene expression analysis has helped to increase reproducibility by aggregating data from diverse populations into a single analysis. To make the multi-cohort analysis process more feasible, we have assembled an analysis pipeline which implements rigorously studied meta-analysis best practices. We have compiled and made publicly available the results of our own multi-cohort gene expression analysis of 103 diseases, spanning 615 studies and 36,915 samples, through a novel and interactive web application...
2016: Pacific Symposium on Biocomputing
https://www.readbyqxmd.com/read/27893043/appropriate-use-of-high-sensitivity-cardiac-troponin-levels-in-patients-with-suspected-acute-myocardial-infarction
#19
Kasper Glerup Lauridsen, Jesper Revsholm, Bo Løfgren
No abstract text is available yet for this article.
February 1, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/27834115/long-term-functional-outcomes-after-radical-cystectomy-with-ileal-bladder-substitute-does-the-definition-of-continence-matter
#20
Fredrik Liedberg, Göran Ahlgren, Gediminas Baseckas, Sigurdur Gudjonsson, Ulf Håkansson, Sara Lindquist, Annica Löfgren, Oliver Patschan, Carina Siller, Gottfrid Sjödahl
OBJECTIVE: Functional outcomes after ileal bladder substitution reflect the expectations of future patients at a particular centre. The aim of this study was to use validated questionnaires and a pad-weighing test to investigate functional outcomes after neobladder reconstruction at long-term follow-up in patients at a single centre. MATERIALS AND METHODS: During 2005 - 2015, 75 patients received a Studer ileal bladder substitute at the Department of Urology, Malmö...
November 11, 2016: Scandinavian Journal of Urology
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