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https://www.readbyqxmd.com/read/28079845/predictive-value-of-c-reactive-protein-and-clinically-relevant-baseline-variables-in-sarcoidosis
#1
Melissa J McDonnell, Mohammed I Saleem, Deidre Wall, J J Gilmartin, R M Rutherford, Anthony O'Regan
BACKGROUND: This study aims to examine the predictive and prognostic implications of C-reactive protein (CRP) and clinically relevant baseline variables in determining treatment indication and disease progression in a large clinical cohort of patients with stable sarcoidosis. METHODS: A retrospective observational study of 328 sarcoidosis patients attending a regional tertiary referral centre over a 26-year period was performed. Clinical, biochemical, radiological and physiological data were analysed according to a clinically relevant dichotomous cutpoint of CRP...
December 23, 2016: Sarcoidosis, Vasculitis, and Diffuse Lung Diseases: Official Journal of WASOG
https://www.readbyqxmd.com/read/28054475/design-and-control-of-integrated-chromatography-column-sequences
#2
Niklas Andersson, Anton Löfgren, Marianne Olofsson, Anton Sellberg, Peter Tiainen, Bernt Nilsson
To increase the productivity in biopharmaceutical production a natural step is to introduce integrated continuous biomanufacturing which leads to fewer buffer and storage tanks, smaller sizes of integrated unit operations and full automation of the operation. The main contribution of this work is to illustrate a methodology for design and control of a downstream process based on integrated column sequences. For small scale production, e.g. pre-clinical studies, integrated column sequences can be implemented on a single chromatography system...
January 5, 2017: Biotechnology Progress
https://www.readbyqxmd.com/read/28052703/a-client-centred-programme-focusing-energy-conservation-for-people-with-heart-failure
#3
Eva-Britt Norberg, Britta Löfgren, Kurt Boman, Patrik Wennberg, Margareta Brännström
AIM: The purpose of this study was to describe clients and occupational therapists (OTs) experiences of a home-based programme focusing energy conservation strategies (ECS) for clients with chronic heart failure (CHF). METHODS: The programme, based on occupational therapy intervention process model (OTIPM), was led by two OTs in primary health care. Five clients' self-reported activities of daily living (ADL), fatigue, depression, goal achievements and use of ECS...
January 5, 2017: Scandinavian Journal of Occupational Therapy
https://www.readbyqxmd.com/read/28018971/integrated-multicohort-analysis-of-systemic-sclerosis-identifies-robust-transcriptional-signature-of-disease-severity
#4
Shane Lofgren, Monique Hinchcliff, Mary Carns, Tammara Wood, Kathleen Aren, Esperanza Arroyo, Peggie Cheung, Alex Kuo, Antonia Valenzuela, Anna Haemel, Paul J Wolters, Jessica Gordon, Robert Spiera, Shervin Assassi, Francesco Boin, Lorinda Chung, David Fiorentino, Paul J Utz, Michael L Whitfield, Purvesh Khatri
Systemic sclerosis (SSc) is a rare autoimmune disease with the highest case-fatality rate of all connective tissue diseases. Current efforts to determine patient response to a given treatment using the modified Rodnan skin score (mRSS) are complicated by interclinician variability, confounding, and the time required between sequential mRSS measurements to observe meaningful change. There is an unmet critical need for an objective metric of SSc disease severity. Here, we performed an integrated, multicohort analysis of SSc transcriptome data across 7 datasets from 6 centers composed of 515 samples...
December 22, 2016: JCI Insight
https://www.readbyqxmd.com/read/27997918/single-nucleotide-polymorphisms-and-cancer-risk-tumor-recurrence-or-survival-of-head-and-neck-cancer-patients
#5
Nongnit Laytragoon-Lewin, Lena Cederblad, Bengt-Åke Andersson, Mattias Olin, Mats Nilsson, Lars Erik Rutqvist, Jan Lundgren, Mats Engström, Wieslaw Tytor, Sture Löfgren, Freddi Lewin
OBJECTIVE: This paper aims at studying the influence of single-nucleotide polymorphisms (SNPs) on cancer risk, tumor recurrence, and survival in head and neck (H&N) cancer patients. METHODS: A total of 45 SNPs in 41 genes were investigated. A total of 174 Caucasian H&N cancer patients and 245 healthy blood donors were enrolled in the study. RESULTS: Ten SNPs were associated with H&N cancer risk, but the identified SNPs differed among males and females...
December 21, 2016: Oncology
https://www.readbyqxmd.com/read/27995653/influence-of-misfit-on-the-occurrence-of-veneering-porcelain-fractures-chipping-in-implant-supported-metal-ceramic-fixed-dental-prostheses-an-in%C3%A2-vitro-pilot-trial
#6
Nils Löfgren, Christel Larsson, Nikos Mattheos, Martin Janda
OBJECTIVE: Technical complications such as veneer fractures are more common in implant-supported than tooth-supported restorations. The underlying causes have not been fully identified. The aim of this study was to evaluate whether misfit between the restoration and the implant may affect the risk of veneer fractures. MATERIALS AND METHODS: Twenty standardized five-unit implant-supported metal-ceramic fixed dental prostheses (FDP)s were manufactured and fixed in acrylic blocks...
December 19, 2016: Clinical Oral Implants Research
https://www.readbyqxmd.com/read/27896970/empowering-multi-cohort-gene-expression-analysis-to-increase-reproducibility
#7
Winston A Haynes, Francesco Vallania, Charles Liu, Erika Bongen, Aurelie Tomczak, Marta Andres-Terrè, Shane Lofgren, Andrew Tam, Cole A Deisseroth, Matthew D Li, Timothy E Sweeney, Purvesh Khatri
A major contributor to the scientific reproducibility crisis has been that the results from homogeneous, single-center studies do not generalize to heterogeneous, real world populations. Multi-cohort gene expression analysis has helped to increase reproducibility by aggregating data from diverse populations into a single analysis. To make the multi-cohort analysis process more feasible, we have assembled an analysis pipeline which implements rigorously studied meta-analysis best practices. We have compiled and made publicly available the results of our own multi-cohort gene expression analysis of 103 diseases, spanning 615 studies and 36,915 samples, through a novel and interactive web application...
2016: Pacific Symposium on Biocomputing
https://www.readbyqxmd.com/read/27893043/appropriate-use-of-high-sensitivity-cardiac-troponin-levels-in-patients-with-suspected-acute-myocardial-infarction
#8
Kasper Glerup Lauridsen, Jesper Revsholm, Bo Løfgren
No abstract text is available yet for this article.
November 23, 2016: JAMA Cardiology
https://www.readbyqxmd.com/read/27834115/long-term-functional-outcomes-after-radical-cystectomy-with-ileal-bladder-substitute-does-the-definition-of-continence-matter
#9
Fredrik Liedberg, Göran Ahlgren, Gediminas Baseckas, Sigurdur Gudjonsson, Ulf Håkansson, Sara Lindquist, Annica Löfgren, Oliver Patschan, Carina Siller, Gottfrid Sjödahl
OBJECTIVE: Functional outcomes after ileal bladder substitution reflect the expectations of future patients at a particular centre. The aim of this study was to use validated questionnaires and a pad-weighing test to investigate functional outcomes after neobladder reconstruction at long-term follow-up in patients at a single centre. MATERIALS AND METHODS: During 2005 - 2015, 75 patients received a Studer ileal bladder substitute at the Department of Urology, Malmö...
November 11, 2016: Scandinavian Journal of Urology
https://www.readbyqxmd.com/read/27797838/systemic-sarcoidosis-first-manifesting-in-a-tattoo-in-the-setting-of-immune-checkpoint-inhibition
#10
Charissa Kim, Jianjun Gao, Vickie R Shannon, Arlene Siefker-Radtke
The use of immune checkpoint inhibitors is revolutionising the treatment of cancer. However, their unique toxicity profile is substantially different from what has been observed with traditional chemotherapy, resulting in a novel learning curve for medical oncologists. Early recognition of these toxicities can make a substantial impact in ameliorating these side effects in the oncological and medical-surgical fields. Here, we present a case of Lofgren syndrome sarcoidosis, which first manifested in a tattoo in a patient with metastatic urothelial cancer on therapy with anti-CTLA-4 (ipilimumab) and anti-PD1 (nivolumab)...
October 26, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27780267/postpartum-hemorrhage-in-women-with-von-willebrand-disease-a-retrospective-observational-study
#11
Igor Govorov, Signe Löfgren, Roza Chaireti, Margareta Holmström, Katarina Bremme, Miriam Mints
INTRODUCTION: von Willebrand disease (VWD) is a hereditary bleeding disorder, caused by a deficiency in the levels and/or function of von Willebrand factor (VWF). Women with VWD appear to be at increased risk of experiencing postpartum hemorrhage (PPH), though the levels of VWF increase during pregnancy. There is limited knowledge of how PPH is associated with the subtype of VWD, plasma levels of other coagulations factors than VWF and given hemostatic treatment. AIMS: The aims were to investigate the incidence of PPH in women with VWD and to analyse the correlation between PPH and: (1) type of VWD, (2) laboratory monitoring of VWF and FVIII and (3) hemostatic drug treatment...
2016: PloS One
https://www.readbyqxmd.com/read/27760571/patients-as-patches-ecology-and-epidemiology-in-healthcare-environments
#12
Eric T Lofgren, Andrea M Egizi, Nina H Fefferman
The modern healthcare system involves complex interactions among microbes, patients, providers, and the built environment. It represents a unique and challenging setting for control of the emergence and spread of infectious diseases. We examine an extension of the perspectives and methods from ecology (and especially urban ecology) to address these unique issues, and we outline 3 examples: (1) viewing patients as individual microbial ecosystems; (2) the altered ecology of infectious diseases specifically within hospitals; and (3) ecosystem management perspectives for infection surveillance and control...
December 2016: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/27732712/hernia-mesh-repair-and-global-surgery
#13
Jessica Beard, Michael Ohene-Yeboah, Jenny Löfgren
No abstract text is available yet for this article.
December 1, 2016: JAMA Surgery
https://www.readbyqxmd.com/read/27709604/annual-research-review-quality-of-life-and-childhood-mental-and-behavioural-disorders-a-critical-review-of-the-research
#14
Ulf Jonsson, Iman Alaie, Anna Löfgren Wilteus, Eric Zander, Peter B Marschik, David Coghill, Sven Bölte
BACKGROUND: An individual's subjective perception of well-being is increasingly recognized as an essential complement to clinical symptomatology and functional impairment in children's mental health. Measurement of quality of life (QoL) has the potential to give due weight to the child's perspective. SCOPE AND METHODOLOGY: Our aim was to critically review the current evidence on how childhood mental disorders affect QoL. First, the major challenges in this research field are outlined...
October 6, 2016: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/27681518/estrogen-receptor-alpha-gene-esr1-polymorphism-can-contribute-to-clinical-findings-in-systemic-lupus-erythematosus-patients
#15
M N Drehmer, D Andrade, I A Pereira, A R Marrero, Y C N Muniz, I R de Souza, S E Löfgren
BACKGROUND: Estrogens have a modulatory effect on several immune responses, many of which are correlated to autoimmune diseases. Estrogens act through binding to their receptors, and an overexpression of these receptors has been identified in patients with different autoimmune diseases. Here we analyzed the association of a putative functional genetic variant in the main estrogen receptor (ERα) gene (ESR1), and the susceptibility to clinical findings and severity of SLE. METHODS: A total of 426 individuals (266 healthy controls and 160 SLE patients) were genotyped for the polymorphism rs2234693 in the ESR1 gene...
September 27, 2016: Lupus
https://www.readbyqxmd.com/read/27681513/advanced-practice-providers-perceptions-of-patient-workload-results-of-a-multi-institutional-survey
#16
April N Kapu, Carmel A McComiskey, Lacey Buckler, Jennifer Derkazarian, Tammy Goda, Maria A Lofgren, Colleen K McIlvennan, Julie Raaum, Patricia M Selig, Corinna Sicoutris, Barbara Todd, Vicki Turner, Elizabeth Card, Nancy Wells
OBJECTIVE: This study examines data collected from a survey of advanced practice providers' (APPs') perceptions of reasonable versus actual APP-to-patient ratios and other factors that affect workload burden in both inpatient and outpatient clinical settings. BACKGROUND: Advanced practice providers provide accessible, cost-effective, and quality care in a growing number of specialty practices across multiple patient care settings. They are caring for higher volumes of patients and assuming more responsibilities while continuing to navigate highly complex healthcare systems...
October 2016: Journal of Nursing Administration
https://www.readbyqxmd.com/read/27674580/patient-experience-survey-of-early-stage-breast-cancer-patients-undergoing-whole-breast-radiation-therapy
#17
G Lee, R Dinniwell, T W Fyles, T D Conrad, K Han, W Levin, F F Liu, S Lofgren, A Koch-Fitsialos, G Devins, N Emad, B Pitcher, T Panzarella, A Koch
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27671710/unlocking-the-black-box-teaching-mathematical-modeling-with-popular-culture
#18
Eric T Lofgren
Mathematical modeling is an important tool in biological research, allowing for the synthesis of results from many studies into an understanding of a system. Despite this, the need for extensive subject matter knowledge and complex mathematics often leaves modeling as an esoteric subspecialty. A 2-fold approach can be used to make modeling more approachable for students and those interested in obtaining a functional knowledge of modeling. The first is the use of a popular culture disease system-a zombie epidemic-to allow for exploration of the concepts of modeling using a flexible framework...
October 2016: FEMS Microbiology Letters
https://www.readbyqxmd.com/read/27658651/a-novel-protocol-for-dispatcher-assisted-cpr-improves-cpr-quality-and-motivation-among-rescuers-a-randomized-controlled-simulation-study
#19
Stinne Eika Rasmussen, Mette Amalie Nebsbjerg, Lise Qvirin Krogh, Katrine Bjørnshave, Kristian Krogh, Jonas Agerlund Povlsen, Ingunn Skogstad Riddervold, Thorbjørn Grøfte, Hans Kirkegaard, Bo Løfgren
BACKGROUND: Emergency dispatchers use protocols to instruct bystanders in cardiopulmonary resuscitation (CPR). Studies changing one element in the dispatcher's protocol report improved CPR quality. Whether several changes interact is unknown and the effect of combining multiple changes previously reported to improve CPR quality into one protocol remains to be investigated. We hypothesize that a novel dispatch protocol, combining multiple beneficial elements improves CPR quality compared with a standard protocol...
January 2017: Resuscitation
https://www.readbyqxmd.com/read/27649279/norovirus-dynamics-in-wastewater-discharges-and-in-the-recipient-drinking-water-source-long-term-monitoring-and-hydrodynamic-modeling
#20
Olaf Dienus, Ekaterina Sokolova, Fredrik Nyström, Andreas Matussek, Sture Löfgren, Lena Blom, Thomas J R Pettersson, Per-Eric Lindgren
Norovirus (NoV) that enters drinking water sources with wastewater discharges is a common cause of waterborne outbreaks. The impact of wastewater treatment plants (WWTPs) on the river Göta älv (Sweden) was studied using monitoring and hydrodynamic modeling. The concentrations of NoV genogroups (GG) I and II in samples collected at WWTPs and drinking water intakes (source water) during one year were quantified using duplex real-time reverse-transcription polymerase chain reaction. The mean (standard deviation) NoV GGI and GGII genome concentrations were 6...
October 4, 2016: Environmental Science & Technology
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