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https://www.readbyqxmd.com/read/28334865/structure-of-human-pofut1-its-requirement-in-ligand-independent-oncogenic-notch-signaling-and-functional-effects-of-dowling-degos-mutations
#1
Brian J McMillan, Brandon Zimmerman, Emily D Egan, Michael Lofgren, Xiang Xu, Anthony Hesser, Stephen C Blacklow
Protein O-fucosyltransferase-1 (POFUT1), which transfers fucose residues to acceptor sites on serine and threonine residues of epidermal growth factor-like repeats of recipient proteins, is essential for Notch signal transduction in mammals. Here, we examine the consequences of POFUT1 loss on the oncogenic signaling associated with certain leukemia-associated mutations of human Notch1, report the structures of human POFUT1 in free and GDP-fucose bound states, and assess the effects of Dowling-Degos mutations on human POFUT1 function...
March 17, 2017: Glycobiology
https://www.readbyqxmd.com/read/28331374/clinical-experience-and-skills-of-physicians-in-hospital-cardiac-arrest-teams-in-denmark-a-nationwide-study
#2
Kasper G Lauridsen, Anders S Schmidt, Philip Caap, Rasmus Aagaard, Bo Løfgren
BACKGROUND: The quality of in-hospital resuscitation is poor and may be affected by the clinical experience and cardiopulmonary resuscitation (CPR) training. This study aimed to investigate the clinical experience, self-perceived skills, CPR training and knowledge of the guidelines on when to abandon resuscitation among physicians of cardiac arrest teams. METHODS: We performed a nationwide cross-sectional study in Denmark. Telephone interviews were conducted with physicians in the cardiac arrest teams in public somatic hospitals using a structured questionnaire...
2017: Open Access Emergency Medicine: OAEM
https://www.readbyqxmd.com/read/28329080/differences-in-immunologic-factors-among-patients-presenting-with-altered-mental-status-during-cryptococcal-meningitis
#3
Sarah Lofgren, Kathy H Hullsiek, Bozena M Morawski, Henry W Nabeta, Reuben Kiggundu, Kabanda Taseera, Abdu Musubire, Charlotte Schutz, Mahsa Abassi, Nathan C Bahr, Lillian Tugume, Conrad Muzoora, Darlisha A Williams, Melissa A Rolfes, Sruti S Velamakanni, Radha Rajasingham, Graeme Meintjes, Joshua Rhein, David B Meya, David R Boulware
Altered mental status in cryptococcal meningitis results in poorer survival, but underlying causes of altered mentation are poorly understood. Within two clinical trials, we assessed risk factors for altered mental status (GCS score<15) considering baseline clinical characteristics, CSF cytokines/chemokines, and antiretroviral therapy. Among 326 enrolled participants, 97 (30%) had GCS<15 and these patients had lower median CSF cryptococcal antigen titers (P=0.042) and CCL2 (P=0.005) but higher opening pressures (320 vs...
January 30, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28324666/gene-expression-analysis-to-assess-the-relevance-of-rodent-models-to-human-lung-injury
#4
Timothy E Sweeney, Shane Lofgren, Purvesh Khatri, Angela J Rogers
Rationale The relevance of animal models to human diseases is an area of intense scientific debate. The degree to which mouse models of lung injury recapitulate human lung injury has never been assessed. Integrating data from both human and animal expression studies allows for increased statistical power and identification of conserved differential gene expression across organisms and conditions. Objectives Comprehensive integration of gene expression data in experimental ALI in rodents compared to humans. Methods We performed two separate gene expression multi-cohort analyses to determine differential gene expression in experimental animal and human lung injury...
March 21, 2017: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/28323065/the-impact-of-fecal-sample-processing-on-prevalence-estimates-for-antibiotic-resistant-escherichia-coli
#5
Sylvia Omulo, Eric T Lofgren, Maina Mugoh, Moshe Alando, Joshua Obiya, Korir Kipyegon, Gilbert Kikwai, Wilson Gumbi, Samuel Kariuki, Douglas R Call
Investigators often rely on studies of Escherichia coli to characterize the burden of antibiotic resistance in a clinical or community setting. To determine if prevalence estimates for antibiotic resistance are sensitive to sample handling and interpretive criteria, we collected presumptive E. coli isolates (24 or 95 per stool sample) from a community in an urban informal settlement in Kenya. Isolates were tested for susceptibility to nine antibiotics using agar breakpoint assays and results were analyzed using generalized linear mixed models...
March 18, 2017: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/28316053/the-use-of-rapid-and-cost-effective-blood-based-biomarkers-in-combination-with-tumour-tnm-stage-for-individual-head-and-neck-cancer-patient-treatment-selection
#6
REVIEW
Nongnit Laytragoon Lewin, Freddi Lewin, Bengt-Åke Andersson, Sture Löfgren, Lars Erik Rutqvist
Head and neck (H&N) cancer is an aggressive disease and the incidence has increased in younger population worldwide. Tumour TNM staging is the main basis for treatment decision despite significant variation in clinical outcome. Survival time of these patients has marginally improved during the last 30 years. Various biomarkers with cumbersome analysis, high cost, time consumption and requirement of special laboratory facilities have been investigated. However, none of these biomarkers have been shown to be suitable to use for individual H&N cancer patient treatment selection in the clinic...
April 2017: Medical Oncology
https://www.readbyqxmd.com/read/28288611/benefits-of-resistance-exercise-in-lean-women-with-fibromyalgia-involvement-of-igf-1-and-leptin
#7
Jan L Bjersing, Anette Larsson, Annie Palstam, Malin Ernberg, Indre Bileviciute-Ljungar, Monika Löfgren, Björn Gerdle, Eva Kosek, Kaisa Mannerkorpi
BACKGROUND: Chronic pain and fatigue improves by exercise in fibromyalgia (FM) but underlying mechanisms are not known. Obesity is increased among FM patients and associates with higher levels of pain. Symptom improvement after aerobic exercise is affected by body mass index (BMI) in FM. Metabolic factors such as insulin-like growth factor 1 (IGF-1) and leptin may be involved. In this study, the aim was to evaluate the role of metabolic factors in lean, overweight and obese women during resistance exercise, in relation to symptom severity and muscle strength in women with FM...
March 14, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28282362/gene-to-gene-interactions-regulate-endogenous-pain-modulation-in-fibromyalgia-patients-and-healthy-controls-antagonistic-effects-between-opioid-and-serotonin-related-genes
#8
Tour Jeanette, Löfgren Monika, Mannerkorpi Kaisa, Gerdle Björn, Larsson Anette, Palstam Annie, Bileviciute-Ljungar Indre, Bjersing Jan, Ingvar Martin, Ernberg Malin, Schalling Martin, Kosek Eva
Chronic pain is associated with dysfunctional endogenous pain modulation, involving both central opioid and serotonergic (5-HT) signaling. Fibromyalgia (FM) is a chronic pain syndrome, characterized by widespread musculoskeletal pain and reduced exercise-induced hypoalgesia (EIH). In this study, we assessed the effects of three functional genetic polymorphisms on EIH in 130 patients with FM and 132 healthy controls (HC). Subjects were genotyped regarding the mu-opioid receptor (OPRM1) gene (rs1799971), the serotonin transporter (5-HTT) gene (5-HTTLPR/rs25531) and the serotonin-1a receptor (5-HT1a) gene (rs6296)...
March 7, 2017: Pain
https://www.readbyqxmd.com/read/28277128/expression-of-cyclooxygenase-1-and-cyclooxygenase-2-syndecan-1-and-connective-tissue-growth-factor-in-benign-and-malignant-breast-tissue-from-premenopausal-women
#9
M Fahlén, H Zhang, L Löfgren, B Masironi, E von Schoultz, B von Schoultz, L Sahlin
Stromal factors have been identified as important for tumorigenesis and metastases of breast cancer. From 49 premenopausal women, samples were collected from benign or malignant tumors and the seemingly normal tissue adjacent to the tumor. The factors studied, with real-time polymerase chain reaction (PCR) and immunohistochemistry, were cyclooxygenase-1 and cyclooxygenase-2 (COX-1 and COX-2), syndecan-1 (S-1) and connective tissue growth factor (CTGF). COX-1 and S-1 mRNA levels were higher in the malignant tumors than in normal and benign tissues...
February 21, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28276729/elevated-calprotectin-in-patients-with-atrial-fibrillation-with-and-without-heart-failure
#10
Lærke V Bruhn, Kasper G Lauridsen, Anders S Schmidt, Hans Rickers, Leif F Bach, Bo Løfgren, Nete Hornung
Calprotectin is an inflammatory marker, which has been found elevated in patients suffering from cardiac conditions, e.g. myocardial infarction, unstable angina and chronic heart failure. Inflammation has further been linked to atrial fibrillation (AF). However, the association between calprotectin and AF is unknown. We aimed to compare calprotectin levels in patients suffering from AF with healthy adults. In addition, AF patients with and without heart failure were compared. Calprotectin was measured in patients undergoing elective direct current cardioversion for AF...
May 2017: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/28275066/cardioversion-efficacy-using-pulsed-biphasic-or-biphasic-truncated-exponential-waveforms-a-randomized-clinical-trial
#11
Anders S Schmidt, Kasper G Lauridsen, Kasper Adelborg, Peter Torp, Leif F Bach, Simon M Jepsen, Nete Hornung, Charles D Deakin, Hans Rickers, Bo Løfgren
BACKGROUND: Several different defibrillators are currently used for cardioversion and defibrillation of cardiac arrhythmias. The efficacy of a novel pulsed biphasic (PB) waveform has not been compared to other biphasic waveforms. Accordingly, this study aims to compare the efficacy and safety of PB shocks with biphasic truncated exponential (BTE) shocks in patients undergoing cardioversion of atrial fibrillation or -flutter. METHODS AND RESULTS: This prospective, randomized study included patients admitted for elective direct current cardioversion...
March 8, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28214538/contemporary-animal-models-of-cardiac-arrest-a-systematic-review
#12
REVIEW
Mikael Vognsen, Bjørn K Fabian-Jessing, Niels Secher, Bo Løfgren, Cameron Dezfulian, Lars W Andersen, Asger Granfeldt
AIM OF THE STUDY: Animal models are widely used in cardiac arrest research. This systematic review aimed to provide an overview of contemporary animal models of cardiac arrest. METHODS: Using a comprehensive research strategy, we searched PubMed and EMBASE from March 8, 2011 to March 8, 2016 for cardiac arrest animal models. Two investigators reviewed titles and abstracts for full text inclusion from which data were extracted according to pre-defined definitions...
February 15, 2017: Resuscitation
https://www.readbyqxmd.com/read/28212248/use-of-echocardiography-in-critical-illness-dead-or-alive-does-it-matter
#13
Rasmus Aagaard, Asger Granfledt, Morten Thingemann Bødtker, Bo Løfgren
No abstract text is available yet for this article.
March 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28206682/cost-effectiveness-of-groin-hernia-repair-from-a-randomized-clinical-trial-comparing-commercial-versus-low-cost-mesh-in-a-low-income-country
#14
J Löfgren, A Matovu, A Wladis, C Ibingira, P Nordin, E Galiwango, B C Forsberg
BACKGROUND: Over 200 million people worldwide live with groin hernia and 20 million are operated on each year. In resource-scarce settings, the superior surgical technique using a synthetic mesh is not affordable. A low-cost alternative is needed. The objective of this study was to calculate and compare costs and cost-effectiveness of inguinal hernia mesh repair using a low-cost versus a commercial mesh in a rural setting in Uganda. METHODS: This is a cost-effectiveness analysis of a double-blinded RCT comparing outcomes from groin hernia mesh repair using a low-cost mesh and a commercially available mesh...
February 16, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/28203697/pandemic
#15
Eric T Lofgren, Kristen M Rapazzo
No abstract text is available yet for this article.
February 15, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28182756/correction-postpartum-hemorrhage-in-women-with-von-willebrand-disease-a-retrospective-observational-study
#16
Igor Govorov, Signe Löfgren, Roza Chaireti, Margareta Holmström, Katarina Bremme, Miriam Mints
[This corrects the article DOI: 10.1371/journal.pone.0164683.].
2017: PloS One
https://www.readbyqxmd.com/read/28159576/humoral-immune-profiling-of-mycobacterial-antigen-recognition-in-sarcoidosis-and-l%C3%A3-fgren-s-syndrome-using-high-content-peptide-microarrays
#17
REVIEW
Giovanni Ferrara, Davide Valentini, Martin Rao, Jan Wahlström, Johan Grunewald, Lars-Olof Larsson, Susanna Brighenti, Ernest Dodoo, Alimuddin Zumla, Markus Maeurer
INTRODUCTION: Sarcoidosis is considered an idiopathic granulomatous disease, although similar immunological and clinical features with tuberculosis (TB) suggest mycobacterial involvement in its pathogenesis. High-content peptide microarrays (HCPM) may help to decipher mycobacteria-specific antibody reactivity in sarcoidosis. METHODS: Serum samples from patients with sarcoidosis, Löfgren's syndrome, and TB, as well as from healthy individuals (12/group), were tested on HCPM containing 5964 individual peptides spanning 154 Mycobacterium tuberculosis proteins displayed as 15-amino acid stretches...
January 31, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28155057/omentectomy-in-addition-to-bariatric-surgery-a-5-year-follow-up
#18
Daniel P Andersson, Daniel Eriksson-Hogling, Jesper Bäckdahl, Anders Thorell, Patrik Löfgren, Mikael Rydén, Peter Arner, Johan Hoffstedt
AIM: Omentectomy in addition to bariatric surgery has been suggested to improve metabolic outcome but short-term (6-24 months) studies have refuted this notion. We investigated whether there was any long-term impact of omentectomy. METHODS: Forty-nine obese women underwent gastric bypass surgery and were randomly assigned to omentectomy (n = 26) or not (n = 23). They were re-examined after 5 years including dual-energy X-ray absorptiometry for body composition, blood pressure and blood sampling...
April 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28143463/monitoring-training-activity-during-gait-related-balance-exercise-in-individuals-with-parkinson-s-disease-a-proof-of-concept-study
#19
RANDOMIZED CONTROLLED TRIAL
David Conradsson, Håkan Nero, Niklas Löfgren, Maria Hagströmer, Erika Franzén
BACKGROUND: Despite the benefits of balance exercise in clinical populations, balance training programs tend to be poorly described, which in turn makes it difficult to evaluate important training components and compare between programs. However, the use of wearable sensors may have the potential to monitor certain elements of balance training. Therefore, this study aimed to investigate the feasibility of using wearable sensors to provide objective indicators of the levels and progression of training activity during gait-related balance exercise in individuals with Parkinson's disease...
January 31, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28129004/interprofessional-education-in-a-student-led-emergency-department-a-realist-evaluation
#20
Anne Ericson, Susanne Löfgren, Gunilla Bolinder, Scott Reeves, Simon Kitto, Italo Masiello
This article reports a realist evaluation undertaken to identify factors that facilitated or hindered the successful implementation of interprofessional clinical training for undergraduate students in an emergency department. A realist evaluation provides a framework for understanding how the context and underlying mechanisms affect the outcome patterns of an intervention. The researchers gathered both qualitative and quantitative data from internal documents, semi-structured interviews, observations, and questionnaires to study what worked, for whom, and under what circumstances in this specific interprofessional setting...
January 27, 2017: Journal of Interprofessional Care
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