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https://www.readbyqxmd.com/read/28937078/acute-kidney-injury-with-granulomatous-interstitial-nephritis-and-vasculitis-revealing-sarcoidosis
#1
Amel Harzallah, Hayet Kaaroud, Karima Boubaker, Samia Barbouch, Rim Goucha, Fethi Ben Hamida, Taieb Ben Abdallah
Sarcoidosis is an inflammatory disease that affects mostly the lungs and lymph glands. Renal involvement is rare and especially vasculitis. We report a case who presented an acute kidney failure and had sarcoidosis with vasculitis and nodular splenic involvement. A 35-year-old woman presenting a Lofgren syndrome was hospitalized for acute renal failure with cervical lymphadenopathy without other clinical findings. Laboratory data disclosed elevated angiotensin converting enzyme serum level. Abdominal ultrasound showed a multinodular spleen...
September 2017: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/28900756/systematic-review-of-interventions-for-depression-for-people-living-with-hiv-in-africa
#2
REVIEW
Sarah M Lofgren, Noeline Nakasujja, David R Boulware
Depression interventions for individuals with HIV/AIDS in Africa are being increasingly evaluated. MEDLINE was searched using key terms: depression, Africa, and HIV, to identify depression interventions for HIV-infected adults in Africa. Perinatal women were excluded. Results were extracted and relative change in depression scores for interventions and net effect calculated. The MEDLINE search yielded 18 articles. Six of seven studies evaluating feasibility were positive, and seven of seven studies evaluating acceptability were also positive...
September 12, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28882898/switch-i-dependent-allosteric-signaling-in-a-g-protein-chaperone-b12-enzyme-complex
#3
Gregory C Campanello, Michael Lofgren, Adam L Yokom, Daniel R Southworth, Ruma Banerjee
G-proteins regulate various processes ranging from DNA replication and protein synthesis to cytoskeletal dynamics and cofactor assimilation, and serve as models for uncovering strategies deployed for allosteric signal transduction. MeaB is a multifunctional G-protein chaperone, which gates loading of the active 5'-deoxyadenosylcobalamin cofactor onto methylmalonyl-CoA mutase (MCM) and precludes loading of inactive cofactor forms. MeaB also safeguards MCM, which uses radical chemistry, against inactivation and rescues MCM inactivated during catalytic turnover by using the GTP-binding energy to offload inactive cofactor...
September 7, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28841883/are-women-adequately-informed-before-gynaecological-surgery
#4
Mojgan Pakbaz, Ewa Rolfsman, Mats Löfgren
BACKGROUND: Surgery for pelvic organ prolapse, urinary incontinence, and hysterectomy are the most common gynaecological surgeries that can affect the function of the bladder and bowel as well as one's sexual life. There is evidence that adequate patient information given preoperatively regarding expected outcomes of surgery is important because well-informed patients are more satisfied with the results of surgery and recover faster. However, there is little known about the amount and quality of information given to women before surgery...
August 25, 2017: BMC Women's Health
https://www.readbyqxmd.com/read/28837681/bispecific-t-cell-engager-bite%C3%A2-antibody-constructs-can-mediate-bystander-tumor-cell-killing
#5
Sandra L Ross, Marika Sherman, Patricia L McElroy, Julie A Lofgren, Gordon Moody, Patrick A Baeuerle, Angela Coxon, Tara Arvedson
For targets that are homogenously expressed, such as CD19 on cells of the B lymphocyte lineage, immunotherapies can be highly effective. Targeting CD19 with blinatumomab, a CD19/CD3 bispecific antibody construct (BiTE®), or with chimeric antigen receptor T cells (CAR-T) has shown great promise for treating certain CD19-positive hematological malignancies. In contrast, solid tumors with heterogeneous expression of the tumor-associated antigen (TAA) may present a challenge for targeted therapies. To prevent escape of TAA-negative cancer cells, immunotherapies with a local bystander effect would be beneficial...
2017: PloS One
https://www.readbyqxmd.com/read/28834807/scope-of-practice-barriers-for-advanced-practice-registered-nurses-a-state-task-force-to-minimize-barriers
#6
Maria A Lofgren, Susan K Berends, Jimmy Reyes, Carmen Wycoff, Meghan Kinnetz, Ami Frohling, Laura Baker, Sue Whitty, Mary Dirks, Mary OʼBrien
Collegial relationships, administrative champions, and persistence are key components to breaking down barriers to advanced practice RN (APRN) practice. This article addresses how Iowa APRNs in a state-sanctioned task force identified barriers for practicing at the top of their licensure in a full practice authority state including defending the right to control the scope of nursing practice in court.
September 2017: Journal of Nursing Administration
https://www.readbyqxmd.com/read/28833079/cancer-associated-faecal-microbial-markers-in-colorectal-cancer-detection
#7
Vincy Eklöf, Anna Löfgren-Burström, Carl Zingmark, Sofia Edin, Pär Larsson, Pontus Karling, Oleg Alexeyev, Jörgen Rutegård, Maria L Wikberg, Richard Palmqvist
Colorectal cancer (CRC) is the second most common cause of cancer death in the western world. An effective screening program leading to early detection of disease would severely reduce the mortality of CRC. Alterations in the gut microbiota has been linked to CRC, but the potential of microbial markers for use in CRC screening has been largely unstudied. We used a nested case-control study of 238 study subjects to explore the use of microbial markers for clbA+ bacteria harbouring the pks pathogenicity island, afa-C+ diffusely adherent Escherichia coli harbouring the afa-1 operon, and Fusobacterium nucleatum in stool as potential screening markers for CRC...
August 22, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28831088/multiple-sources-and-sinks-of-dissolved-inorganic-carbon-across-swedish-streams-refocusing-the-lens-of-stable-c-isotopes
#8
Audrey Campeau, Marcus B Wallin, Reiner Giesler, Stefan Löfgren, Carl-Magnus Mörth, Sherry Schiff, Jason J Venkiteswaran, Kevin Bishop
It is well established that stream dissolved inorganic carbon (DIC) fluxes play a central role in the global C cycle, yet the sources of stream DIC remain to a large extent unresolved. Here, we explore large-scale patterns in δ(13)C-DIC from streams across Sweden to separate and further quantify the sources and sinks of stream DIC. We found that stream DIC is governed by a variety of sources and sinks including biogenic and geogenic sources, CO2 evasion, as well as in-stream processes. Although soil respiration was the main source of DIC across all streams, a geogenic DIC influence was identified in the northernmost region...
August 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28829676/content-validation-of-a-home-parenteral-nutrition-patient-reported-outcome-questionnaire
#9
Tracy-Lee Miller, Geoffrey W Greene, Ingrid Lofgren, Mary L Greaney, Marion F Winkler
BACKGROUND: Patient-reported outcome (PRO) instruments collect information from patients about health conditions and disease management, including quality of life (QOL). Clinicians acknowledge patient concerns about QOL but need guidance to assess the nature and severity of individually experienced problems. The Home Parenteral Nutrition (HPN)-Patient-Reported Outcome Questionnaire (PROQ) was developed for use during medical appointments or homecare visits to address this gap. The purpose of this research was to provide evidence that the HPN-PROQ items and scale possess content validity...
August 1, 2017: Nutrition in Clinical Practice
https://www.readbyqxmd.com/read/28829481/fr%C3%A3-n-pek-till-patientnytta
#10
Jenny Löfgren, Pär Nordin, Andreas Wladis
No abstract text is available yet for this article.
August 22, 2017: Läkartidningen
https://www.readbyqxmd.com/read/28827283/shared-%C3%AE-%C3%AE-tcr-usage-in-lungs-of-sarcoidosis-patients-with-l%C3%A3-fgren-s-syndrome
#11
Angela M Mitchell, Ylva Kaiser, Michael T Falta, Daniel J Munson, Laurie G Landry, Anders Eklund, Maki Nakayama, Jill E Slansky, Johan Grunewald, Andrew P Fontenot
Sarcoidosis is a granulomatous disease that primarily affects the lungs and is characterized by an accumulation of CD4(+) T cells in the bronchoalveolar lavage (BAL). Previous work has indicated that HLA-DRB1*03:01(+) (DR3(+)) patients diagnosed with the acute form of the disease, Löfgren's syndrome (LS), have an accumulation of CD4(+) T cells bearing TCRs using TRAV12-1 (formerly AV2S3). However, the importance of these α-chains in disease pathogenesis and the paired TCRβ-chain remains unknown. This study aimed to identify expanded αβTCR pairs expressed on CD4(+) T cells derived from the BAL of DR3(+) LS patients...
August 21, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28822756/differences-in-psychosocial-and-behavioral-variables-by-dietary-screening-tool-risk-category-in-older-adults
#12
Geoffrey W Greene, Ingrid Lofgren, Chelsea Paulin, Mary L Greaney, Phillip G Clark
BACKGROUND: The Dietary Screening Tool (DST) has been validated as a dietary screening instrument for older adults defining three categories of potential nutritional risk based on DST score cutoffs. Previous research has found that older adults classified as being "at risk" differed from those categorized as being "not at risk" for a limited number of health-related variables. The relationship between risk categories and a wide variety of variables has not yet been explored. This research will contribute to an increased understanding of clustering of multiple health concerns in this population...
August 17, 2017: Journal of the Academy of Nutrition and Dietetics
https://www.readbyqxmd.com/read/28798033/a-prospective-study-comparing-99m-tc-hdp-planar-bone-scintigraphy-and-whole-body-spect-ct-with-18-f-fluoride-pet-ct-and-18-f-fluoride-pet-mri-for-diagnosing-bone-metastases
#13
Johan Löfgren, Jann Mortensen, Sine Hvid Rasmussen, Claus Madsen, Annika Loft, Adam Espe Hansen, Peter Oturai, Karl Erik Jensen, Mette Louise Mørk, Michala Reichkendler, Liselotte Højgaard, Barbara M Fischer
We prospectively evaluate and compare the diagnostic performance of (99m)Tc-HDP planar bone scintigraphy (pBS), (99m)Tc-HDP SPECT/CT, (18)F-NaF PET/CT and (18)F-NaF PET/MRI for the detection of bone metastases. Methods: 117 patients with histologically proven malignancy referred for clinical pBS were prospectively enrolled. pBS and whole-body SPECT/CT were performed followed by (18)F-NaF PET/CT within 9 days. (18)F-NaF PET/MRI was also performed in 46 patients. A "truth panel" including clinical follow-up served as standard of reference...
August 10, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28774285/estimating-the-impact-post-randomization-changes-in-staff-behavior-in-infection-prevention-trials-a-mathematical-modeling-approach
#14
Eric T Lofgren
BACKGROUND: Randomized controlled trials (RCTs) of behavior-based interventions are particularly vulnerable to post-randomization changes between study arms. We assess the impact of such a change in a large, multicenter study of universal contact precautions to prevent infection transmission in intensive care units. METHODS: We construct a stochastic mathematical model of methicillin-resistant Staphylococcus aureus (MRSA) acquisition in a simulated 18-bed intensive care unit (ICU)...
August 3, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28750461/l%C3%A3-fgren-s-syndrome-diagnosis-management-and-disease-pathogenesis
#15
Bekir Karakaya, Ylva Kaiser, Coline H M van Moorsel, Johan Grunewald
No abstract text is available yet for this article.
August 2017: Seminars in Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28728893/2015-revised-utstein-style-recommended-guidelines-for-uniform-reporting-of-data-from-drowning-related-resuscitation-an-ilcor-advisory-statement
#16
Ahamed H Idris, Joost J L M Bierens, Gavin D Perkins, Volker Wenzel, Vinay Nadkarni, Peter Morley, David S Warner, Alexis Topjian, Allart M Venema, Christine M Branche, David Szpilman, Luiz Morizot-Leite, Masahiko Nitta, Bo Løfgren, Jonathon Webber, Jan-Thorsten Gräsner, Stephen B Beerman, Chun Song Youn, Ulrich Jost, Linda Quan, Cameron Dezfulian, Anthony J Handley, Mary Fran Hazinski
BACKGROUND: Utstein-style guidelines use an established consensus process, endorsed by the international resuscitation community, to facilitate and structure resuscitation research and publication. The first "Guidelines for Uniform Reporting of Data From Drowning" were published over a decade ago. During the intervening years, resuscitation science has advanced considerably, thus making revision of the guidelines timely. In particular, measurement of cardiopulmonary resuscitation elements and neurological outcomes reporting have advanced substantially...
September 2017: Resuscitation
https://www.readbyqxmd.com/read/28724492/evaluation-of-pain-assessment-techniques-and-analgesia-efficacy-in-a-female-guinea-pig-cavia-porcellus-model-of-surgical-pain
#17
Vanessa L Oliver, Stephanie Athavale, Katherine E Simon, Lon V Kendall, Jean A Nemzek, Jennifer L Lofgren
Guinea pigs (Cavia porcellus) are a frequently used species in research, often involving potentially painful procedures. Therefore, evidence-based recommendations regarding analgesia are critically needed to optimize their wellbeing. Our laboratory examined the efficacy of carprofen and extended-release (ER) buprenorphine, alone and as a multimodal combination, for relieving postsurgical pain in guinea pigs. Animals were assessed by using evoked (mechanical hypersensitivity), nonevoked (video ethogram, cageside ethogram, time-to-consumption test), and clinical (weight loss) measurements for 96 h during baseline, anesthesia-analgesia, and hysterectomy conditions...
July 1, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/28723801/multidisciplinary-approach-and-long-term-follow-up-in-a-series-of-640-consecutive-patients-with-sarcoidosis-cohort-study-of-a-40-year-clinical-experience-at-a-tertiary-referral-center-in-barcelona-spain
#18
Juan Mañá, Manuel Rubio-Rivas, Nadia Villalba, Joaquim Marcoval, Adriana Iriarte, María Molina-Molina, Roger Llatjos, Olga García, Sergio Martínez-Yélamos, Vanessa Vicens-Zygmunt, Cristina Gámez, Ramón Pujol, Xavier Corbella
Cohort studies of large series of patients with sarcoidosis over a long period of time are scarce. The aim of this study is to report a 40-year clinical experience of a large series of patients at Bellvitge University Hospital, a tertiary university hospital in Barcelona, Spain. Diagnosis of sarcoidosis required histological confirmation except in certain specific situations. All patients underwent a prospective study protocol. Clinical assessment and follow-up of patients were performed by a multidisciplinary team...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28721435/effect-of-a-combined-tai-chi-resistance-training-and-dietary-intervention-on-cognitive-function-in-obese-older-women
#19
F Xu, M J Delmonico, I E Lofgren, K M Uy, S A Maris, D Quintanilla, A G Taetzsch, J Letendre, L Mahler
Cognitive decline in older adults is a major public health problem and can compromise independence and quality of life. Exercise and diet have been studied independently and have shown to be beneficial for cognitive function, however, a combined Tai Chi, resistance training, and diet intervention and its influence on cognitive function has not been undertaken. The current study used a 12-week non-randomized research design with experiment and control groups to examine the effect of a combined Tai Chi, resistance training, and diet intervention on cognitive function in 25 older obese women...
2017: Journal of Frailty & Aging
https://www.readbyqxmd.com/read/28717140/common-variants-of-t-cells-contribute-differently-to-phenotypic-variation-in-sarcoidosis
#20
Natalia V Rivera, Michael Hagemann-Jensen, Manuel A R Ferreira, Susanna Kullberg, Anders Eklund, Nicholas G Martin, Leonid Padyukov, Johan Grunewald
The involvement of the immune system, particularly the role of T-cells, in sarcoidosis is unclear. The existence of higher CD4+ T-cells and increased CD4/CD8 ratio may indicate a pathogenic role of T-cells in the disease. In this study, we quantified the contribution of T-cells associated variants and of CD4/CD8 ratio in sarcoidosis phenotypes, Löfgren's syndrome (LS) and non- Löfgren's syndrome (non-LS). We employed a polygenic-based approach using genome-wide association studies results on relative levels of T-cells in healthy individuals to measure the genetic contribution of T-cells in sarcoidosis entities...
July 17, 2017: Scientific Reports
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