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acute pancreatitis lactate level

Erik S Knudsen, Uthra Balaji, Elizaveta Freinkman, Peter McCue, Agnieszka K Witkiewicz
Pancreatic ductal adenocarcinoma (PDAC) has a dismal prognosis. The aggressiveness and therapeutic recalcitrance of this malignancy has been attributed to multiple factors including the influence of an active desmoplastic stroma. How the stromal microenvironment of PDAC contributes to the fatal nature of this disease is not well defined. In the analysis of clinical specimens, we observed diverse expression of the hypoxic marker carbonic anhydrase IX and the lactate transporter MCT4 in the stromal compartment...
September 7, 2016: Oncotarget
W H He, Y Zhu, Y Zhu, P Liu, H Zeng, L Xia, X Huang, Y P Lei, N H Lü
OBJECTIVE: To investigate the difference in severity and clinical outcomes between hypertriglyceridemic pancreatitis (HTGP) and acute pancreatitis (AP) of other causes, and to analyze the correlation between the serum triglyceride (TG) level <24 h after onset and the disease severity. METHODS: Patients were selected from the AP database of the First Affiliated Hospital of Nanchang University, who were admitted between January 2005 and December 2013, aged ≥18 and ≤85 years, excluding pregnant or lactating women...
August 23, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
(no author information available yet)
OBJECTIVE: To observe the occurrence rate of elevated serum amylase and lipase in critically ill children, to explore the relationship between elevated pancreatic enzymes and pancreatic injury, and the effect of elevated pancreatic enzymes on state of illness and the prognosis. METHOD: The data of cases treated in pediatric intensive care unit(ICU) of 17 children's hospitals were collected prospectively from January 2012 to March 2014 according to the inclusion and exclusion criteria...
September 2016: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
F Zhu, Y Guan, R Zhang
BACKGROUND: Linoleic acid has been implicated in the pathogenesis of acute pancreatitis. However, molecular mechanisms underlying adverse effects of large-dose linoleic acid remain unclear. Current study aimed to explore the impact of high-dose linoleic acid on the activation of Janus kinase 2 (JAK2)-signal transducers and activators of transcription 3 (STAT3) pathway, cytokine production, and lipogenesis in pancreatic exocrine cells. METHODS: MTT assay was used to detect the viability of AR42J rat pancreatic exocrine cells, and lactate dehydrogenase assay was utilized to detect cytotoxicity...
July 21, 2016: Current Molecular Medicine
Luyao Zhang, Yao Nie, Yishan Zheng, Lu Ke, Zhihui Tong, Weiqin Li, Jieshou Li
BACKGROUND: Recent studies suggest that beta-adrenergic blockers attenuate systemic inflammation and improve survival in sepsis. We investigated whether esmolol can reduce lung injury and modulate inflammatory response in a rat model of severe acute pancreatitis (SAP). METHODS: A taurocholate-induced SAP was used, with or without continuously intravenous pumping of esmolol (15 mg/kg/h). Heart rate and arterial pressure were monitored. Nine hrs after esmolol administration, blood was drawn for blood gas analyses and cytokine (interleukin(IL)-6, tumor necrosis factor (TNF)-α) detections, lungs and pancreata were isolated for measurements of myeloperoxidase (MPO) activity and histological damage...
September 2016: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
Mehmet Ali Kosekli, Ugur Sungurtekin, Veli Cobankara, Ozlem Ozmen, Sima Sahinduran, Mustafa Yilmaz
OBJECTIVES: To evaluate the effects of certolizumab, a pegylated monoclonal antibody to tumor necrosis factor α (TNF-α), on experimentally induced acute pancreatitis. METHODS: Healthy Wistar Albino male rats (n = 36) were randomly divided into 4 groups (9 rats in each group): group 1, control group; group 2, certolizumab group; group 3, cerulein group; and group 4, cerulein + certolizumab group. Acute edematous pancreatitis was induced via intraperitoneal injection of 80-μg/kg cerulein (20 μg/kg, 4 times at 1-hour intervals) in groups 3 and 4...
September 2016: Pancreas
Tan Lu, Chao Zhang, Mingxiang Chai, Yongbo An
BACKGROUND: Recent studies showed that Isoquercetin (Iso), a novel extracts of plants and fruits could protect neuronal cells from neurotoxicity and neuro-inflammation. However, its role in acute spinal cord injury (ASCI) have not been elucidated. In the present study, we investigated whether Iso could prevent Tunicamycin (TUN)-induced rat dorsal root ganglion (DRG) neurons from apoptosis and endoplasmic reticulum (ER) stress. METHODS: DRG neurons were pre-treated with different doses of Iso for 24h (h) and then were stimulated with TUN (0...
May 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Gina N Woods, Alec Saitman, Hanlin Gao, Nigel J Clarke, Robert L Fitzgerald, Nai-Wen Chi
The CYP24A1 gene encodes a mitochondrial 24-hydroxylase that inactivates 1,25(OH)2 D. Loss-of-function mutations in CYP24A1 cause hypercalcemia, nephrolithiasis and nephrocalcinosis. We describe a woman with CYP24A1 deficiency and recurrent gestational hypercalcemia. Her first pregnancy, at age 20, resulted in the intrauterine demise of twin fetuses. Postpartum, she developed severe hypercalcemia (14 mg/dL), altered mental status, and acute pancreatitis. Her PTH was suppressed (6 pg/mL) and her 1,25(OH)2 D was elevated (165 and 195 pg/mL on postpartum day 1 and 5, respectively)...
April 22, 2016: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
H Guo, D-W Suo, H-P Zhu, X-M Sun, J Chen
OBJECTIVE: Severe acute pancreatitis (SAP) can often be complicated by acute lung injury (ALI) and acute respiratory distress syndrome (ARDS), leading to increased mortality. Early blood purification clears inflammatory cytokines and promotes immune function recovery. Here we evaluated the usefulness of this therapy in SAP complicated by ALI. PATIENTS AND METHODS: 32 patients received routine treatment (control group), whereas other 32 patients received routine treatment and early blood purification therapy (study group)...
March 2016: European Review for Medical and Pharmacological Sciences
Hyung-Min Yu, Eun Myung, Seung-Hun Kim, Dae-Seong Myung, Sung-Bum Cho, Wan-Sik Lee, Young-Hoe Hur, Jin-Woong Kim, Kyung-Hwa Lee, Young-Eun Joo
No abstract text is available yet for this article.
May 2016: Journal of Digestive Diseases
Giuseppe Losurdo, Andrea Iannone, Mariabeatrice Principi, Michele Barone, Nunzio Ranaldo, Enzo Ierardi, Alfredo Di Leo
BACKGROUND AND AIMS: Acute pancreatitis (AP) in elderly may have an aggressive course due to co-morbidity high rate and severe presentation. We retrospectively evaluated AP severity and its underlying factors in a group of elderly patients compared with an adult population sample. METHODS: Forty-two elderly patients (65-102years) and 48 controls (19-64years) admitted at our Unit for biliary or alcoholic AP were retrospectively enrolled. AP severity was evaluated by the Atlanta classification and Ransom score...
May 2016: European Journal of Internal Medicine
Sara Querido, Inês Carvalho, Filipa Moleiro, Pedro Póvoa
An otherwise healthy 37-year-old man was admitted to hospital with uncontrollable vomiting and abdominal pain. Lithiasic acute pancreatitis was diagnosed on the basis of clinical symptoms along with raised serum amylase levels and compatible findings in ultrasonography and CT scan. Two Ranson criteria (lactate dehydrogenase over 350 U/L and aspartate aminotransferase over 250 U/L) were present at admission. The patient was transferred to an intensive care unit (ICU); intravenous crystalloids were prescribed and analgaesics were administered for pain relief...
2016: BMJ Case Reports
Xiaoqin Wang, Xiaoyan Zeng, Bo Yang, Shan Zhao, Wei Chen, Xuan Guo
The present study aimed to investigate the effects of treatment with thymosin α1 (TA1) or interferon α (IFNα) following the establishment of severe acute pancreatitis (SAP) in rats. A total of 144 Sprague‑Dawley rats were randomly divided into four groups. The rats in all four groups were celiotomized, and the rats in the control group were administered with an intravenous injection of saline. The three other groups were administered with 5% 1 ml/kg sodium taurocholate via the cholangiopancreatic duct...
November 2015: Molecular Medicine Reports
Jing Tong, Xincheng Yao, Hong Zeng, Gao Zhou, Yuxin Chen, Bingxin Ma, Youwei Wang
ETHNOPHARMACOLOGICAL RELEVANCE: Cichorium glandulosum Boiss. et Huet was used historically in Uyghur folk medicine. Its roots, seeds, and aerial parts are extensively used by Uyghur residents in Xinjiang to eliminate savda typhoid, dredge and cure obstructive jaundice variety liver disorders. AIM OF THE STUDY: To evaluate the hepatoprotective activity of total flavonoids (TFs) obtained from C. glandulosum seeds against carbon tetrachloride (CCl4)-induced liver damage in vitro and in vivo...
November 4, 2015: Journal of Ethnopharmacology
Jennifer M Rojas, Miles E Matsen, Thomas O Mundinger, Gregory J Morton, Darko Stefanovski, Richard N Bergman, Karl J Kaiyala, Gerald J Taborsky, Michael W Schwartz
OBJECTIVE: Central administration of ligands for fibroblast growth factor receptors (FGFRs) such as fibroblast growth factor-19 (FGF19) and FGF21 exert glucose-lowering effects in rodent models of obesity and type 2 diabetes (T2D). Conversely, intracerebroventricular (icv) administration of the non-selective FGFR inhibitor (FGFRi) PD173074 causes glucose intolerance, implying a physiological role for neuronal FGFR signaling in glucose homeostasis. The current studies were undertaken to identify neuroendocrine mechanisms underlying the glucose intolerance induced by pharmacological blockade of central FGFRs...
August 2015: Molecular Metabolism
Lina Yan, Qiang Fu, Chao Du, Yangzi Yu, Jing Li, Qingquan Liu, Chengrui Xue, Qinghui Qi, Jianping Li
OBJECTIVE: To investigate the risk factors of patients with acute lung injury/acute respiratory distress syndrome (ALI/ARDS) complicated with Yangming Fushi syndrome. METHODS: A prospective study was conducted. From August 2009 to July 2013, 206 patients with Yangming Fushi syndrome combined with ALI/ARDS were enrolled in the intensive care units (ICUs) of the following five hospitals: Tianjin Nankai Hospital, Dongzhimen Hospital Affiliated to Beijing Traditional Chinese Medicine University, General Hospital of Tianjin Medical University, the First Affiliated Hospital of Dalian Medical University, and Wuxi Third People's Hospital in Jiangsu Province...
July 2015: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
Qiukui Deng, Chuanxiu Xu, Rencai Wang, Jianying Zheng, Shuai Li, Qunhua Jin, Yapei Yang
No abstract text is available yet for this article.
October 2015: Journal of Molecular Neuroscience: MN
Kais Mnafgui, Ines Khlif, Raouf Hajji, Fatma Derbali, Ftouma Kraiem, Hedi Ellefi, Thomas Michel, Maria Halabalaki, Alexios Leandros Skaltsounis, Abdelfattah Elfeki, Neji Gharsallah, Noureddine Allouche
OBJECTIVE: Myocardial infarction remains the major cause of global death due to cardiovascular diseases. This study aimed to assess the protective role of oleuropein in attenuating the cardiac remodeling in isoproterenol-induced myocardial infarction in rats. METHODS AND RESULTS: Male Wistar rats were randomly divided into four groups, control, isoproterenol (Isop) and pretreated animals with oleuropein at two different doses (20 and 40 mg/kg) orally for 7 days and intoxicated with isoproterenol (Isop+Oleu20) and (Isop+Oleu40) groups...
2015: Toxicology Mechanisms and Methods
Jian Huang, Zhengwang Wu, Shiqi Lu, Jiaqing Shen, Xiaoming Kong, Yueping Shen
The clinical usefulness of soluble B7-H2 (sB7-H2) as an early indicator of acute pancreatitis (AP) remains unclear, so we performed the present study to investigate this issue. For our cohort, we recruited 75 patients with AP, 70 patients with other abdominal sepsis, and 20 healthy control individuals. The sB7-H2 levels of AP patients or healthy control individuals were measured by enzyme-linked immunosorbent assay (ELISA). The sB7-H2 levels in patients with AP rather than other patients with abdominal sepsis were significantly higher than those in healthy controls...
2015: Laboratory Medicine
Nan Li, Ying Tian, Chunli Wang, Peng Zhang, Shengyi You
The aim of the present study was to evaluate the effects of Lai Fu Cheng Qi decoction on myocardial injury in rats with severe acute pancreatitis (SAP). In total, 30 rats were randomly divided into sham, SAP and decoction treatment groups. SAP was induced by a retrograde pancreatic duct injection of 5% sodium taurocholate in the SAP and decoction treatment groups. Rats in decoction treatment group also received intragastric administration of Lai Fu Cheng Qi decoction. The serum levels of creatine kinase isoenzyme (CK-MB) and lactate dehydrogenase (LDH) were detected using an automatic biochemical analyzer...
April 2015: Experimental and Therapeutic Medicine
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